BETA MERCAPTOETHANOL ( BETA MERKAPTO ETANOL)

BETA MERCAPTOETHANOL ( BETA MERKAPTO ETANOL)

 BETA MERCAPTOETHANOL(BETA MERKAPTO ETANOL)

CAS Number 60-24-2

EC Number 200-464-6

SYNONYM: 2-MERCAPTOETHANOL; ß-Mercaptoethanol; 2-Hydroxyethylmercaptan; BME; Thioethylene glycol; Linear Formula: HSCH2CH2OH; Molecular Weight: 78.13; Beilstein Registry Number: 773648; EC Number: 200-464-6; MDL number: MFCD00004890; ß-mercaptoethanol; BME; 2BME; 2-ME; ß-met;2-mercaptoethanol; 60-24-2; Mercaptoethanol; Thioglycol; Beta-Mercaptoethanol; Ethanol, 2-mercapto-; 2-Thioethanol; 2-Sulfanylethanol; Thioethylene glycol; 2-Hydroxyethanethiol; 2-Hydroxyethyl mercaptan; 2-Hydroxy-1-ethanethiol; Monothioglycol; Thiomonoglycol; 2-Mercapto-1-ethanol; 1-Ethanol-2-thiol; Hydroxyethyl mercaptan; Monothioethylene glycol; 2-Mercaptoethyl alcohol; 2-ME; Mercaptoetanol; Ethylene glycol, monothio-; 1-Hydroxy-2-mercaptoethane; 1-Mercapto-2-hydroxyethane; 2-Hydroxyethylmercaptan; Emery 5791; USAF EK-4196; Monothioethyleneglycol; beta-Hydroxyethanethiol; 2-sulfanylethan-1-ol; .beta.-Mercaptoethanol; .beta.-Hydroxyethanethiol; beta-Hydroxyethylmercaptan; NSC 3723; UNII-14R9K67URN; 2-mercapto ethanol; CCRIS 2097; HSDB 5199; EINECS 200-464-6; UN2966; .beta.-Hydroxyethylmercaptan; 2-SULFHYDRYL-ETHANOL; BRN 0773648; AI3-07710; 14R9K67URN; CHEBI:41218; betamercaptoethanol; DGVVWUTYPXICAM-UHFFFAOYSA-N; 2-Mercaptoethanol, 99%, pure; 2-Mercaptoethanol, >=99.0%; BME; 2mercaptoethanol; b-mercaptoethanol; 2-mercapto-ethanol; 2-sulfanyl-ethanol; hydroxyethyl sulfide; mercaptoethyl alcohol; 2-Sulfanylethanol #; 2-hydroxy-ethanethiol; 2-mercaptoethan-1-ol; HSCH2CH2OH; D06HKH; D0Q5FV; WLN: SH2Q; EC 200-464-6; AC1L1BR3; 4-01-00-02428 (Beilstein Handbook Reference); DivK1c_000784; BDBM7971; CHEMBL254951; DTXSID4026343; CTK2F3219; HMS502H06; KBio1_000784; NSC3723; MolPort-003-938-002; NINDS_000784; Thioglycol [UN2966] [Poison]; 2-Mercaptoethanol, 98% 250g; KS-000017OG; NSC-3723; Thioglycol [UN2966] [Poison]; ZINC8216595; 2-Mercaptoethano; [forElectrophoresis]; MFCD00004890; STL482546; 2-Mercaptoethanol, for electrophoresis; AKOS000118900; CCG-231050; DB03345; MCULE; 2252943288; UN 2966; IDI1_000784; AN-41806; BP-21398; LS-66846; 2-Mercaptoethanol, for synthesis, 99.0%; KB-173393; KB-173421; TR-020825; FT-0612764; M0058; M1948; 2341-EP2284157A1; 2341-EP2295429A1; 2344-EP2272972A1; 2344-EP2272973A1; 2344-EP2277872A1; 2344-EP2305648A1; C00928; 16605-EP2281563A1; 16605-EP2316459A1; 67670-EP2269996A1; 67670-EP2272972A1; 67670-EP2272973A1; 67670-EP2277872A1; 67670-EP2292597A1; 67670-EP2295414A1; 67670-EP2301627A1; 67670-EP2305808A1; 67670-EP2308839A1; 67670-EP2377849A2; 2-Mercaptoethanol, SAJ special grade, >=99.0%; A832651; InChI=1/C2H6OS/c3-1-2-4/h3-4H,1-2H; Q-200296; I14-19306; F0001-1577; 2-Mercaptoethanol, for HPLC derivatization, >=99.0% (GC); 2-Mercaptoethanol, BioUltra, for molecular biology, >=99.0% (GC); 155613-89-1; 2-Mercaptoethanol, for molecular biology, for electrophoresis, suitable for cell culture, BioReagent, 99% (GC/titration); 2-Mercaptoethanol, PharmaGrade, Manufactured under appropriate controls for use as raw material in pharma or biopharmaceutical production.; 2-mercaptoethanol,beta-mercaptoethanol,2-hydroxy-1-ethanethiol,2-hydroxyethyl mercaptan,monothioethyleneglycol,thioglycol; 99748-78-4; SEO;2 Mercaptoethanol; 2-ME; 2-Mercaptoethanol; Mercaptoethanol; 2-mercaptoethanol; mercaptoethanol; thioglycol; beta-mercaptoethanol; ethanol; 2-mercapto; 2-thioethanol; 2-hydroxy-1-ethanethiol; thioethylene glycol; 2-hydroxyethanethiol; 2-hydroxyethyl mercaptandroxy; Risk: 20/22-24-34-51/53; Safety: 26-36/37/39-45-61; 2-Sulfanylethan-1-ol; 2-Hydroxy-1-ethanethiol; 2-Mercanptoethanol; Thioglycol; 14R9K67URN; 200-464-6;2-Mercaptoethanol; 2-Sulfanylethanol; 2-Sulfanylethanol;2-Sulfanyléthanol; 2-sulfhydryl-ethanol; 60-24-2; Ethanol; 2-mercapto-; mercaptoethanol; mercaptoethyl alcohol; MFCD00004890; Monothioethylene glycol; Monothioethyleneglycol; ß-Hydroxyethanethiol; ß-Hydroxyethylmercaptan; ß-mercaptoethanol; ß-Mercaptoethanol; &ß;-mercaptoethanol; (2S,3S)-1,4-dimercaptobutane-2,3-diol; ?-MERCAPTOETHANOL|2-SULFANYLETHAN-1-OL; 1,1,2,2-tetradeuterio-1-deuteriooxy-2-deuteriosulfanylethane; 155-04-4; 1-Ethanol-2-thiol; 1-Hydroxy-2-mercaptoethane; 1-Mercapto-2-hydroxyethane; 2 Mercaptoethanol; 2,3-DIHYDROXY-1,4-DITHIOBUTANE; 203645-37-8; 284474-53-9; 2-Hydroxy-1-Ethanethiol; 2-Hydroxy-1-Ethanethiol; 2-Hydroxyethanethiol; 2-Hydroxyethyl mercaptan; 2-Hydroxyethylmercaptan;2-mercapto ethanol;2-Mercapto-1-ethanol; 2-Mercaptobenzothiazole zinc salt; 2-Mercaptoethanol-1,1,2,2-d4; 2-Mercaptoethyl alcohol; 2-mercaptoethynol; 2-Sulfanylethan-1-ol; 2-sulfanylethynol; 2-Thioethanol;2-????; 4-01-00-02428;DTT; DTV; EINECS 200-464-6; Ethylene glycol, monothio-ETHYLTHIO; 2-HYDROXY-; Hydroxyethyl mercaptan; hydroxyethyl sulfide; hydroxyethyl sulfide|&ß;-mercaptoethanol; IDI1_000784; InChI=1/C2H6OS/c3-1-2-4/h3-4H,1-2H; Mercaptoetanol; Monothioglycol; SH2Q; ß-mercaptoethanol; thioethylene glycol; Thioglycol; Thiomonoglycol; UN 2966; UNII:14R9K67URN; UNII-14R9K67URN; WLN: SH2Q; ß Mercaptoethanol; ß-Hydroxyethanethiol; ß-Hydroxyethylmercaptan;1017944; 1068852; 1088828; 1086429; 1104362; 1093708; 1086428; 1021562; 1024822; 1021565; 1024821, 1021564; 1028369; 1033065; 1028386; 1028385; 1033120; ß-mercaptoethanol; ß Mercaptoethanol Sds Page; ß Glucans; Mercaptoethanol; 2-Mercaptoethanol; ß; Beta Mercaptoethanol Western Blot; ß Glucan; Oat ß Glucans; ß-Cyfluthrin; ß Sitosterol; 2 Mercaptoethanol Gibco; DS(CD2)2OD; 2-Mercaptoethanol; 2-Mercaptoethanol; 2-Mercaptoethanol, electrophoresis grade; 2-Mercaptoethanol, molecular biology grade; 2-Mercaptoethanol, molecular biology grade; beta-Mercaptoethanol [60-24-2]; 2-Mercaptoethanol-1,1,2,2-d4 [284474-53-9]; 2-Mercaptoethanol-d6 [203645-37-8];2-hydroxyethyldisulfide + 2 glutathione › 2 2-mercaptoethanol + glutathione disulfide;Ammonium persulfate analytical grade; 3-Mercapto-1,2-propanediol; 2- Mercaptoethanol electrophoresis grade; 2- Mercaptoethanol molecular biology grade; N,N,N’,N’- Tetramethyl-ethylenediamine; Tris-(2-carboxyethyl)phosphine hydrochloride;2-Mercaptoethanol (2-ME); Mercury (II); Potentiometric titration; beta-Mercaptoethanol; mercaptoéthanoL; mercapto- +? ethanol; ß-Mercaptoethanol; 2-Hydroxyethylmercaptan; BME; Thioethylene; Glycol; 2-Hydroxyethyl Mercaptan; Thioethylene Glycol; Thioglycol; 1,1,2,2-tetradeuterio-1-deuteriooxy-2-deuteriosulfanylethane; 2-Hydroxyethyl mercaptan; beta-Mercaptoethanol; ß-Hydroxyethanethiol; ß-Mercaptoethanol; (mer-kap’to-eth’a-nol);Beta merkaptaoetanol ; Betamerkapto etanol ; Beta merkapto etanol; Beta mercapto etanol ; Beta mercapto ethanol ; Betamercapto ethanol ; 2-Sulfanylethan-1-ol ; 2-Hydroxy-1-ethanethiol ; ß-Mercaptoethanol , Thioglycol ; ß Mercaptoethanol , ß Mercapto ethanol ; ß-Mercapto ethanol ; 1-Hydroxy-2-mercaptoethane ; 1-Mercapto-2-hydroxyethane ; 2-Hydroxy-1-ethanethiol ; 2-Hydroxyethanethiol ; 2-Hydroxyethyl mercaptan ; 2-ME ; 2-MERCAPTO ETHANOL ; 2-Mercapto-1-ethanol ; 2-mercaptoetanol ; 2-Mercaptoethanol ; 2-Mercaptoethyl alcohol ; 2-Sulfanylethanol ; Ethanol, 2-mercapto ; Ethanol, 2-mercapto- , Ethylene glycol, monothio- ; Hydroxyethyl mercaptan ; Mercaptoethanol ; MONOTHIOAETHYLENGLYKOL ; Monothioethylene glycol ; Monothioglycol ; NSC 3723 ; Thioethylene glycol ; THIOGLYCOL ; Thiomonoglycol ; UN 2966 ; UN 2966 ; ß-Hydroxyethanethiol ; ß-Hydroxyethylmercaptan ; ß-Mercaptoethanol , 2-mercaptoethanol ; Mercaptoethanol ; Thioglycol; Beta-Mercaptoethanol ; Ethanol, 2-mercapto-; 2-Thioethanol ; ß Mercaptoethanol; 2Hydroxyethylmercaptan, BME, Thioethylene glycol ; Metatags : merkaptoetanol, mercaptoethanol, 2-Mercaptoethanol, Thioglycol, cas no : 60-24-2, beta, merkapto, etanol, tüy dükücü ; 2-Mercaptoethanol; 1-Ethanol-2-thiol; 2-Hydroxy-1-ethanethiol; 2-Hydroxyethyl mercaptan; ; 2-Thioethanol; beta-Mercaptoethanol; Mercaptoethanol; Monothioethyleneglycol; Thiomonoglycol; Ethanol, 2-mercapto-; Thioglycol ; Thioglycol; 2-Hydroxyethyl mercaptan; 2-Thioethanol; ; Eemery 5791; 1-Ethanol-2-thiol; 2-hydroxy-1-ethanethiol; Beta-Mercaptoethanol; Thiomonoglycol ; beta-mercaptoethanol; 2-ME ; b-ME ; 2- thioethanol ; 2-hydroxyethylmercaptan; 1-ethane-2-thiol; thioglycol ; BME ; 2-ME ; emery5791 ; Emery 5791 ;THIOGLYCOL;Sipomer 2ME ; usafek-4196 ; USAF ek-4196 ; 2-THIOETHANOL ; Monothioglycol;bet;a-Merkaptoetanol; BME; Tiyoglikol; 2, Merkaptoetanol; 2-Hidroksietil Merkaptan; 2-Mercaptoetanol Saf; P-mersaptoetanol; 2-Hydroxyethylmercaptan; BME; Tioetilen glikol; Dorusal Formül: HSCH2CH2OH; Moleküler arlk: 78.13; Beilstein Sicil Numaras: 773648; EC Numaras: 200-464-6; MDL numaras: MFCD00004890; B-merkaptoetanol; BME; 2BME; 2-Me; ß-met, 2-merkaptoetanol; 60-24-2; merkaptoetanolu; tiyoglikol; Beta-Merkaptoetanol; Etanol, 2-merkapto-; 2-tiyoetanol; 2-Sulfanylethanol; Tioetilen glikol; 2-Hydroxyethanethiol; 2-Hidroksietil merkaptan; 2-Hidroksi-1-etantiyol; Monothioglycol; Thiomonoglycol; 2-merkapto-1-etanol; 1-etanol-2-tiol; Hidroksietil merkaptan; Monotioetilen glikol; 2-Merkaptoetil alkol; 2-Me; merkaptoetanol; Etilen glikol, monotiyo; 1-Hidroksi-2-merkaptoetan; 1-Merkapto-2-hidroksietan; 2-Hydroxyethylmercaptan; Zmpara 5791; USAF EK-4196; Monothioethyleneglycol; Beta-Hydroxyethanethiol; 2-sulfanylethan-1-ol; ft-merkaptoetanol; p-Hydroxyethanethiol; Beta-Hydroxyethylmercaptan; NSC 3723; LXVIII-14R9K67URN; 2-merkapto etanol; CCRIS 2097; HSDB 5199; EINECS 200-464-6; UN2966;2-Me; 2-Merkaptoetanol; merkaptoetanolu; 2-merkaptoetanol; merkaptoetanol; tioglikol; beta-merkaptoetanol; etanol; 2-merkapto; 2-tiyoetanol; 2-hidroksi-1-etantiyol; tioetilen glikol; 2-hydroxyethanethiol; 2-hidroksietil merkaptandroksi; Risk: 20 / 22-24-34-51 / 53; Güvenlik: 26-36 / 37 / 39-45-61; 2-Sulfanylethan-1-ol; 2-Hidroksi-1-etantiyol; 2-Mercanptoethanol; tiyoglikol; 14R9K67URN; 200-464-6 2-Merkaptoetanol; 2-Sulfanylethanol; 2-Sulfanylethanol 2-Sulfanyléthanol; 2-sülfhidril-etanol; 60-24-2; Etanol; 2-merkapto-; merkaptoetanol; merkaptoetil alkol; MFCD00004890; Monotioetilen glikol; Monothioethyleneglycol; ß-Hydroxyethanethiol; ß-Hydroxyethylmercaptan; B-merkaptoetanol; P-mersaptoetanol; Ve ß; merkaptoetanol; (2S, 3S) -1,4-dimercaptobutane-2,3-diol; Merkaptoetanol | 2-SULFANYLETHAN-1-OL; 1,1,2,2-tetradeuterio-1-deuteriooxy-2-deuteriosulfanylethane; 155-04-4; 1-etanol-2-tiol; 1-Hidroksi-2-merkaptoetan; 1-Merkapto-2-hidroksietan; 2 Merkaptoetanol; 2,3-dihidroksi-1,4-DITHIOBUTANE; 203645-37-8; 284474-53-9; 2-Hidroksi-1-etantiyol; 2-Hidroksi-1-etantiyol; 2-Hydroxyethanethiol; 2-Hidroksietil merkaptan; 2-Hidroksietilmerkaptan, 2-merkapto etanol, 2-Merkapto-1-etanol; 2-Merkaptobenzotiyazol çinko tuzu; 2-Merkaptoetanol-1,1,2,2-d4; 2-Merkaptoetil alkol; 2-mercaptoethynol; 2-Sulfanylethan-1-ol; 2-sulfanylethynol; 2-tiyoetanol; 2 – ????; 4-01-00-02428; DTT; DTV; EINECS 200-464-6; Etilen glikol, monothio-ETHYLTHIO; 2-Hidroksi-; Hidroksietil merkaptan; hidroksietil sülfit; hidroksietil sülfit | -Merkaptoetanol; IDI1_000784; InChl = 1 / C2H6OS / c3-1-2-4 / h3-4H, 1-2H; merkaptoetanol; Monothioglycol; SH2Q; B-merkaptoetanol; tioetilen glikol; tiyoglikol; Thiomonoglycol; BM 2966; LXVIII: 14R9K67URN; LXVIII-14R9K67URN; WLN: SH2Q; Merc Merkaptoetanol; ß-Hydroxyethanethiol; ß-Hydroxyethylmercaptan; 1017944; 1068852; 1088828; 1086429; 1104362; 1093708; 1086428; 1021562; 1024822; 1021565; 1024821, 1021564; 1028369; 1033065; 1028386; 1028385; 1033120; B-merkaptoetanol; Merc Merkaptoetanol Sds Sayfas; Gl Glukanlar; merkaptoetanolu; 2-Merkaptoetanol; 2-; B; Mercaptoethanol; mercaptaetanol; merkaptaetanol; etanol; mercapt; merkapt; merkap; to; merkap to ethanol; MERKAPTO; MERKAP; MERKAPTOETANOL; MERKAPTO ETANOL; MERKAPTOETHANOL;beta; betamerkapto; betamerkap; betamerkaptoetanol; betamerkapto etanol; beta etanol; beta mercapta;

Properties

Related Categories: Antioxidants and Reducing Agents for Protein Stabilization, Biochemicals and Reagents, Building Blocks, Chemical Synthesis, HIS Select Supporting Products and Reagents,
HIS-Select, Molecular Biology, Organic Building Blocks, Protein Modification, Protein Structural Analysis, Proteins and Derivatives, Proteomics, Purification and Detection, Reagents and Products for use with HIS-Select, Reagents for Protein Stabilization, Reagents for reduction of proteins, Recombinant Protein Expression and Analysis, Reduction and Oxidation, Sulfur Compounds, Thiols/Mercaptans

Molecular Formula:C2H6OS or HSCH2CH2OH
Molecular Weight:78.129 g/mol
InChI Key:DGVVWUTYPXICAM-UHFFFAOYSA-N
vapor density:2.69 (vs air)
vapor pressure:1 mmHg ( 20 °C)
expl. lim. :18 %
concentration:14.3 M (pure liquid)
refractive index: n20/D 1.500(lit.)
bp: 157 °C(lit.)
density: 1.114 g/mL at 25 °C(lit.)
storage temp.: 2-8°C

2-Mercaptoethanol (also ß-mercaptoethanol, BME, 2BME, 2-ME or ß-met) is the chemical compound with the formula HOCH2CH2SH. ME or ßME, as it is commonly abbreviated, is used to reduce disulfide bonds and can act as a biological antioxidant by scavenging hydroxyl radicals (amongst others). It is widely used because the hydroxyl group confers solubility in water and lowers the volatility. Due to its diminished vapor pressure, its odor, while unpleasant, is less objectionable than related thiols.

2-Mercaptoethanol

2-Mercaptoethanol is one of the most common agents used for disulfide reduction. Sometimes referred to as ß-mercaptoethanol, it is a clear, colorless liquid with an extremely strong odor. All operations with this chemical should be performed in a well-ventilated fume hood. The reduction of protein disulfides with 2-mercaptoethanol proceeds rapidly via a two-step process involving an intermediate mixed disulfide. Due to its strong reducing properties, the reagent is used most often when complete disulfide reduction is required. It can also be used to cleave disulfide-containing crosslinking agents. Usually a concentration of 0.1-M 2-mercaptoethanol will cleave a disulfide-containing crosslinker and liberate conjugated proteins

Reducing proteins

Some proteins can be denatured by 2-mercaptoethanol, which cleaves the disulfide bonds that may form between thiol groups of cysteine residues. In the case of excess 2-mercaptoethanol, the following equilibrium is shifted to the right:

RS-SR + 2 HOCH2CH2SH ? 2 RSH + HOCH2CH2S-SCH2CH2OH
Reaction scheme for the cleavage of disulfide bonds by 2-mercaptoethanol
By breaking the S-S bonds, both the tertiary structure and the quaternary structure of some proteins can be disrupted.Because of its ability to disrupt the structure of proteins, it was used in the analysis of proteins, for instance, to ensure that a protein solution contains monomeric protein molecules, instead of disulfide linked dimers or higher order oligomers. However, since 2-mercaptoethanol forms adducts with free cysteines and is somewhat more toxic, dithiothreitol (DTT) is generally more used especially in SDS-PAGE. DTT is also a more powerful reducing agent with a redox potential (at pH 7) of -0.33 V, compared to -0.26 V for 2-mercaptoethanol.

Molecules of 2-mercaptoethanol (ME) were spontaneously chemisorbed on silver, copper, and gold surfaces. Surface-enhanced Raman scattering investigation revealed that, as for unsubstituted alkanethiols, the average orientation of the “molecular chain” of ME is the most perpendicular to the metal surface for ME molecules adsorbed on silver. Immersion of an ME-modified electrode in diluted ME solution leads to quick desorption of a portion of the monolayer and an increase in the relative surface concentration of the gauche conformer. The time constant of this rearrangement (below 1 min) is more than 1 order of magnitude shorter than that of monolayers formed from analogous thiols (HS-(CH2)2-X) with X = CH3, NH2, COOH, or SO3Na. The structure of the ME monolayer is highly pH-sensitive, but it is independent of the presence of neutral salts in solutions. In acidic solutions, the surface concentration of a gauche conformer considerably increases. Since protonation of a significant number of hydroxyl groups is unlikely under the conditions used, it is likely that in acidic solutions the kinetics of the desorption and the desorption/adsorption equilibrium are changed. It is probable that desorption of ME as thiol molecules is facilitated because some of the sulfur atoms of ME adsorbed as thiolate are protonated. We also found an analogous effect, although less pronounced, for monolayers self-assembled from propanethiol. This indicates that this mechanism, so far not considered, can also be important for some other (especially short-chain) thiols. In basic solutions, the concentration of a trans conformer increases and probably some of the hydroxyl groups dissociate. For all investigated solutions, the structure of the ME monolayer on gold was found to be less affected by its surroundings than that of monolayers on silver or copper.

2-Mercaptoethanol (also called Thioglycol) is a clear, colorless liquid with disagreeable odor.Beta mercaptoethanol is miscible in water and nearly all common organic solvents.Beta merkapto ethanol is used as a intermediate for the synthesis of PVC heat stabilizers and as a chain transfer agent in the manufacture of PVC. Beta mercapto ethanol is used as a building block to produce corp protection products, dispersants, fibers, textiles, .dyes, and pharmaceuticals. 2 Mercaptoethanol is used as a component of corrosion inhibitors and ore floatation agent. 2 mercaptoethyl alcohol is used in as a raw material for leather and fur industry, cosmetics, hair removal.

2-Mercaptoethanol is often used interchangeably with dithiothreitol (DTT) or the odorless tris(2-carboxyethyl)phosphine (TCEP) in biological applications

Consumer & Industrial Applications

Ink & Dye Additives: We offer hydrocarbon compounds that serve as ink carriers as well as sulfur chemicals that are effective solvents in digital image processing.

Food & Nutrition Applications

To help the agricultural industry flourish in its efforts to maintain fertile land, grow crops and raise healthy livestock, produces agrochemical intermediates such as 2-mercaptoethanol.

Petroleum & Refinery

2ME or BME is a highly volatile, yet water soluble material that is widely used in cleaning agents, as a corrosion inhibitor for performance material (pipe) and as a tin stabilizer in PVC production.

Polymers and Rubber Applications

Normal mercaptans are used as reactants in the synthesis of antioxidants, which minimize undesirable effects from processes such as the stabilization of tin.
2-mercaptoethanol is also used as a chain transfer agent in processes where control of molecular weight is critical.

Water Treatment Applications

2ME or BME is a highly volatile, yet water soluble material that is widely used in cleaning agents, as a corrosion inhibitor for performance material (pipe) and as a tin stabilizer in PVC production.

Özellikleri

lgili Kategoriler: Protein Stabilizasyonu çin Antioksidanlar ve Düürücü Ajanlar, Biyokimyasallar ve Reaktifler, Yap Talar, Kimyasal Sentez, HIS Select Destek Ürünleri ve Reaktifleri,
HIS-Select, Moleküler Biyoloji, Organik Yap Talar, Protein Modifikasyonu, Protein Yapsal Analizi, Proteinler ve Türevleri, Proteomik, Artma ve Tespit, Proteinler ve HIS-Select ile Kullanlan Ürünler, Protein Stabilizasyonu için Reaktifler, Proteinlerin Azaltlmas için Reaktifler, Rekombinant Protein Ekspresyonu ve Analizi, ndirgenme ve Yükseltgenme, Sülfür Bileikleri, Tiyoller / Merkaptanlar

Moleküler Formül: C2H6OS veya HSCH2CH2OH
Moleküler arlk: 78.129 g / mol
InChI Anahtar: DGVVWUTYPXICAM-UHFFFAOYSA-N
buhar younluu 2,69 (vs vs)
buhar basnc 1 mmHg (20 ° C)
InChI Anahtar DGVVWUTYPXICAM-UHFFFAOYSA-N
tahlil% 99.0
expl. lim. % 18
konsantrasyon 14.3 M (saf sv)
krlma indisi n20 / D 1.500 (lit.)
bp 157 ° C (lit.)
25 ° C’de younluk 1.114 g / mL (lit.)
saklama derecesi. 2-8 ° C

2-Merkaptoetanol (ayrca ß-merkaptoetanol, BME, 2BME, 2-ME veya ß-met), HOCH2CH2SH formülüne sahip kimyasal bileiktir. Genel olarak ksaltld gibi ME veya ßME, disülfit balarn azaltmak için kullanlr ve hidroksil radikallerini temizleyerek (dierleri arasnda) biyolojik bir antioksidan görevi görebilir. Hidroksil grubu suda çözünürlüü salad ve uçuculuu azaltt için yaygn olarak kullanlmaktadr. Azalan buhar basnc nedeniyle, kokusu tatsz olsa da, ilgili tiyollerden daha az sakncaldr.

2-Merkaptoetanol

2-Merkaptoetanol, disülfit indirgenmesinde kullanlan en yaygn ajanlardan biridir. Bazen ß-merkaptoetanol olarak adlandrlr, son derece güçlü bir kokusu olan berrak, renksiz bir svdr. Bu kimyasalla yaplan tüm ilemler, iyi havalandrlan bir duman davlumbaznda yaplmaldr. Protein disülfidlerinin 2-merkaptoetanol ile azaltlmas, bir ara kark disülfid içeren iki aamal bir ilemle hzla ilerler. Güçlü indirgeme özelliklerinden dolay, reaktif tam disülfit indirgemesi gerektiinde en sk kullanlr. Disülfit içeren çapraz balama maddelerini ayrmak için de kullanlabilir. Genellikle bir 0.1-M2-merkaptoetanol konsantrasyonu bir disülfid içeren çapraz balaycy parçalayacak ve konjuge proteinleri serbest brakacaktr

Proteinleri azaltmak

Baz proteinler, sistein tortularnn tiyol gruplar arasnda oluabilen disülfür balarn parçalayan 2-merkaptoetanol ile denatüre edilebilir. Ar 2-merkaptoetanol durumunda, aadaki denge saa kaydrlr:

RS – SR + 2 HOCH2CH2SH? 2 RSH + HOCH2CH2S – SCH2CH2OH
Disülfit balarnn 2-merkaptoetanol ile parçalanmas için reaksiyon emas
SS balarn krarak hem üçüncül yap hem de baz proteinlerin kuaterner yaps bozulabilir. Proteinlerin yapsn bozma kabiliyetinden dolay, protein analizinde, örnein bir protein çözeltisinin kullanlmasn salamak için kullanlmtr. disülfit bal dimerler veya daha yüksek dereceli oligomerler yerine monomerik protein moleküllerini içerir. Bununla birlikte, 2-merkaptoetanol, serbest sisteinlerle katk maddesi oluturduundan ve bir miktar daha toksik olduundan, ditiyotreitol (DTT) genellikle özellikle SDS-PAGE’de kullanlr. DTT ayrca 2-merkaptoetanol için -0.26 V ile karlatrldnda -0.33 V’luk bir redoks potansiyeli olan (pH 7’de) daha güçlü bir indirgeyici maddedir.

2-merkaptoetanol (ME) molekülleri, gümü, bakr ve altn yüzeylerde kendiliinden kemorbe edildi. Yüzey arttrlm Raman saçlma aratrmas, ikame edilmemi alkanetillerde olduu gibi, ME’nin “moleküler zincirinin” ortalama yöneliminin, gümü üzerinde adsorbe edilen ME molekülleri için metal yüzeye en dik olduunu ortaya koydu. ME modifiyeli bir elektrotun seyreltilmi ME çözeltisine daldrlmas, tek tabakann bir ksmnn hzl bir ekilde desorpsiyonuna ve gauche konformerinin nispi yüzey konsantrasyonunda bir arta yol açar. Bu yeniden düzenlemenin zaman sabiti (1 dakikadan az), X = CH3, NH2, COOH veya S03Na ile benzer tiollerden (HS- (CH2) 2-X) oluturulan mono tabakalardan 1 kat daha büyüktür. ME tek tabakasnn yaps oldukça pH duyarldr, ancak çözeltilerdeki nötr tuzlarn varlndan bamszdr. Asidik çözeltilerde, bir gauche konformerinin yüzey konsantrasyonu önemli ölçüde artar. Önemli sayda hidroksil grubunun protonlanmas, kullanlan koullar altnda pek olas olmadndan, asidik çözeltilerde desorpsiyon kinetiinin ve desorpsiyon / adsorpsiyon dengesinin deimesi muhtemeldir. ME’nin tiyol molekülleri olarak desorpsiyonunun kolaylatrlmas muhtemeldir, çünkü ME’nin tiyolat olarak adsorbe edilen kükürt atomlarnn bazlar protonlanr. Propanetiolden kendiliinden monte edilmi tek tabakalar için, daha az belirgin olmasna ramen, benzer bir etki bulduk. Bu, u ana kadar düünülmeyen bu mekanizmann dier baz (özellikle ksa zincirli) tiyoller için de önemli olabileceini göstermektedir. Temel çözeltilerde, bir trans konformerinin konsantrasyonu artar ve muhtemelen baz hidroksil gruplarnn ayrr. Aratrlan tüm çözümler için, ME tek katmannn altn üzerindeki yapsnn, çevresi tarafndan gümü veya bakr üzerindeki tek katmanlardan daha az etkilendii bulundu.

2-Merkaptoetanol (ayrca Thioglycol olarak da bilinir), berrak, renksiz bir svdr ve kokusuzdur. Merkaptoetanol, suda ve neredeyse tüm genel organik çözücülerde karabilir. Merkapto etanol, PVC s stabilizatörlerinin sentezi için bir ara ürün olarak ve bir zincir olarak kullanlr. PVC üretiminde transfer maddesi. Beta merkapto etanol, koru koruma ürünleri, dispersanlar, lifler, tekstiller, boyalar ve farmasötikler üretmek için yap ta olarak kullanlr. 2 Merkaptoetanol, korozyon önleyicilerin ve cevher yüzdürme ajannn bir bileeni olarak kullanlr. Deri ve kürk endüstrisi, kozmetik ve epilasyon hammaddelerinde 2 merkaptoetil alkol kullanlr.

2-Merkaptoetanol, genellikle biyolojik uygulamalarda, dithiothreitol (DTT) veya kokusuz tris (2-karboksietil) fosfin (TCEP) ile birbirlerinin yerine kullanlr

Tüketici ve Endüstriyel Uygulamalar

Mürekkep ve Boya Katk Maddeleri: Dijital görüntü ilemede etkili solventler olan sülfür kimyasallarnn yan sra mürekkep tayc olarak görev yapan hidrokarbon bileikleri sunuyoruz.
 
Yiyecek ve Beslenme Uygulamalar

Tarm sektörünün verimli araziyi sürdürme, mahsul yetitirme ve salkl hayvan yetitirme çabalarnda gelimesine yardmc olmak, 2-merkaptoetanol gibi agrokimyasal ara ürünler üretmek.
 
Petrol ve Rafineri

2ME veya BME, temizlik maddelerinde yaygn olarak kullanlan, performans materyali (boru) için bir korozyon önleyici ve PVC üretiminde kalay stabilizatörü olarak yaygn olarak kullanlan, suda çözünen fakat uçucu bir malzemedir.
 
Polimerler ve Kauçuk Uygulamalar

Normal merkaptanlar, antioksidanlarn sentezinde, kalayn stabilizasyonu gibi ilemlerden istenmeyen etkileri en aza indiren reaktifler olarak kullanlr.
 2-merkaptoetanol, moleküler arln kontrolünün kritik olduu ilemlerde bir zincir transfer maddesi olarak da kullanlr.
  
Su Artma Uygulamalar

2ME veya BME, temizlik maddelerinde yaygn olarak kullanlan, performans