PEG 400
PEG 400
synonyms:
PEG; Macrogol; Polyoxyethlene; Aquaffin; Nycoline; alpha-hydro-omega-hydroxypoly ethanediyl; polyethylene glycols; Poly Ethylene Oxide; Polyoxyethylene; Polyglycol; ethanediol Ehoxylated; Polyoxyethylene ether; Polyoxyethylene; Poly(ethylene glycol); Carbowax®; Polyglycol; Polyethylene glycol 200, 300, 400, 600,1000,1450, 3350, 400, 6000, 8000 and 20000;ETHYLENE GLYCOL;1,2-ethanediol;Ethane-1,2-diol;107-21-1;glycol;monoethylene glycol;1,2-Dihydroxyethane;2-hydroxyethanol;Glycol alcohol;Ethylene alcohol;polyethylene glycol;Macrogol;Fridex;Tescol;Ethylene dihydrate;Norkool;Macrogol 400 BPC;Dowtherm SR 1;Carbowax 400;CCRIS 3744;Carbowax 1000;Dowtherm 400;1,2-ethylene glycol;Ethylene glycol polymer;HSDB 5012;NCI-C00920;HOCH2CH2OH;Union Carbide XL 54 Type I De-icing Fluid;PEG 3350;EINECS 203-473-3;M.e.g.;Ethylene glycol homopolymer;Polyethylene glycol 1000;Polyethylene Glycol 400;EPA Pesticide Chemical Code 042203;1,2-Ethanediol homopolymer;FC72KVT52F;AI3-03050;PEG;CHEBI:30742;LYCAIKOWRPUZTN-UHFFFAOYSA-N;PEG 400;1, 2-Ethanediol;DuPont Zonyl FSO Fluorinated Surfactants;alpha-Hydro-omega-hydroxypoly(oxyethylene);DSSTox_CID_597;H(OCH2CH2)nOH;DSSTox_RID_75680;DSSTox_GSID_20597;alpha-Hydro-omega-hydroxypoly(oxy-1,2-ethanediyl);Glycol, polyethylene;Miralax;Polyethylene oxide;CAS-107-21-1;Polyethylene Glycols;Polyethylene glycol3350;Athylenglykol; Aquaffin;Badimol;Carbowax; Modopeg;Nosilen;Nycoline;ehtylene glycol;ethylen glycol;PEG; Macrogol; Polyoxyethlene; Aquaffin; Nycoline; alpha-hydro-omega-hydroxypoly ethanediyl; polyethylene glycols; Poly Ethylene Oxide; Polyoxyethylene; Polyglycol; ethanediol Ehoxylated; Polyoxyethylene ether; Polyoxyethylene; Poly(ethylene glycol); Carbowax®; Polyglycol; Polyethylene glycol 200, 300, 400, 600,1000,1450, 3350, 400, 6000, 8000 and 20000;ETHYLENE GLYCOL;1,2-ethanediol;Ethane-1,2-diol;107-21-1;glycol;monoethylene glycol;1,2-Dihydroxyethane;2-hydroxyethanol;Glycol alcohol;Ethylene alcohol;polyethylene glycol;Macrogol;Fridex;Tescol;Ethylene dihydrate;Norkool;Macrogol 400 BPC;Dowtherm SR 1;Carbowax 400;CCRIS 3744;Carbowax 1000;Dowtherm 400;1,2-ethylene glycol;Ethylene glycol polymer;HSDB 5012;NCI-C00920;HOCH2CH2OH;Union Carbide XL 54 Type I De-icing Fluid;PEG 3350;EINECS 203-473-3;M.e.g.;Ethylene glycol homopolymer;Polyethylene glycol 1000;Polyethylene Glycol 400;EPA Pesticide Chemical Code 042203;1,2-Ethanediol homopolymer;FC72KVT52F;AI3-03050;PEG;CHEBI:30742;LYCAIKOWRPUZTN-UHFFFAOYSA-N;PEG 400;1, 2-Ethanediol;DuPont Zonyl FSO Fluorinated Surfactants;alpha-Hydro-omega-hydroxypoly(oxyethylene);DSSTox_CID_597;H(OCH2CH2)nOH;DSSTox_RID_75680;DSSTox_GSID_20597;alpha-Hydro-omega-hydroxypoly(oxy-1,2-ethanediyl);Glycol, polyethylene;Miralax;Polyethylene oxide;CAS-107-21-1;Polyethylene Glycols;Polyethylene glycol3350;Athylenglykol; Aquaffin;Badimol;Carbowax; Modopeg;Nosilen;Nycoline;ehtylene glycol;ethylen glycol;ethylene-glycol;etylene glycol;Carbowax Sentry;Pluracol E;Polyaethylenglykol;Aquacide III;Ilexan E;Bradsyn PEG;ethylene alcohol;Merpol OJ;Polyaethylenglykole;MEG 100;Alkox SR;Oxide Wax AN; PEG200?300?400?600?800?1000?1500?2000?3000?400?6000 ?8000,Polyglycol, Polyethylene oxide, Polyoxy ethylene,PEG; Carbowax®; Polyglycol; Polyethylene glycol 200, 300, 400, 600,1000,1450, 3350, 400, 6000, 8000 and 20000;ETHYLENE GLYCOL;1,2-ethanediol;Ethane-1,2-diol;107-21-1;glycol;monoethylene glycol;1,2-Dihydroxyethane;2-hydroxyethanol;Glycol alcohol;Ethylene alcohol;polyethylene glycol;Macrogol;Fridex;Tescol;Ethylene dihydrate;Norkool;Macrogol 400 BPC;Dowtherm SR 1;Carbowax 400;CCRIS 3744;Carbowax 1000;Dowtherm 400;1,2-ethylene glycol;Ethylene glycol polymer;HSDB 5012;NCI-C00920;HOCH2CH2OH;Union Carbide XL 54 Type I De-icing Fluid;PEG 3350;EINECS 203-473-3;M.e.g.;Ethylene glycol homopolymer;Polyethylene glycol 1000;Polyethylene Glycol 400;EPA Pesticide Chemical Code 042203;1,2-Ethanediol homopolymer;FC72KVT52F;AI3-03050;PEG;CHEBI:30742;LYCAIKOWRPUZTN-UHFFFAOYSA-N;PEG 400;1, 2-Ethanediol;DuPont Zonyl FSO Fluorinated Surfactants;alpha-Hydro-omega-hydroxypoly(oxyethylene);DSSTox_CID_597;(OCH2CH2)nOH; DSSTox_RID_75680; DSSTox_GSID_20597; alpha-Hydro-omega-hydroxypoly(oxy-1,2-ethanediyl);ethylene-glycol;etylene glycol;Carbowax Sentry;Pluracol E;Polyaethylenglykol;Aquacide III;Ilexan E;Bradsyn PEG;ethylene alcohol;Merpol OJ;Polyaethylenglykole;MEG 100;Alkox SR;Oxide Wax AN; PEG200?300?400?600?800?1000?1500?2000?3000?400?6000 ?8000,Polyglycol, Polyethylene oxide, Polyoxy ethylene,PEG; Carbowax®; Polyglycol; Polyethylene glycol 200, 300, 400, 600,1000,1450, 3350, 400, 6000, 8000 and 20000;ETHYLENE GLYCOL;1,2-ethanediol;Ethane-1,2-diol;107-21-1;glycol;monoethylene glycol;1,2-Dihydroxyethane;2-hydroxyethanol;Glycol alcohol;Ethylene alcohol;polyethylene glycol;Macrogol;Fridex;Tescol;Ethylene dihydrate;Norkool;Macrogol 400 BPC;Dowtherm SR 1;Carbowax 400;CCRIS 3744;Carbowax 1000;Dowtherm 400;1,2-ethylene glycol;Ethylene glycol polymer;HSDB 5012;NCI-C00920;HOCH2CH2OH;Union Carbide XL 54 Type I De-icing Fluid;PEG 3350;EINECS 203-473-3;M.e.g.;Ethylene glycol homopolymer;Polyethylene glycol 1000;Polyethylene Glycol 400;EPA Pesticide Chemical Code 042203;1,2-Ethanediol homopolymer;FC72KVT52F;AI3-03050;PEG;CHEBI:30742;LYCAIKOWRPUZTN-UHFFFAOYSA-N;PEG 400;1, 2-Ethanediol;DuPont Zonyl FSO Fluorinated Surfactants;alpha-Hydro-omega-hydroxypoly(oxyethylene);DSSTox_CID_597;(OCH2CH2)nOH; DSSTox_RID_75680; DSSTox_GSID_20597; alpha-Hydro-omega-hydroxypoly(oxy-1,2-ethanediyl);Glycol, polyethylene;Miralax;Polyethylene oxide;CAS-107-21-1;Polyethylene Glycols;Polyethylene glycol 350;Athylenglykol;Aquaffin; Badimol; Carbowax; Modopeg;Nosilen;Nycoline;ehtylene glycol;ethylen glycol;ethylene-glycol;etylene glycol;Carbowax Sentry;Pluracol E;Polyaethylenglykol;Aquacide III;Ilexan E;Bradsyn PEG;ethylene alcohol;Merpol OJ;Polyaethylenglykole;MEG 100;Alkox SR;Oxide WaxPOLETLEN GLKOL,POLYETLENGLCOL,POLETHLENE GLYCOL,POLETHELENE pOLYethylen glikol 400; Polyethylene glycol 400; Polyethylene glycol400; Polyethylene glycol-400; Polyethylene Glycol 400; Polyethyleneglycol 400; Polyethylene glycol/400; Polietilen Glikol; Polietilen Glikol 400; Polietilen Glikol400; Polietilen glikol 400; Polietilen Glikol 400; POLETLEN GLKOL 400; POLETLEN GLKOL400; POLETLEN GLKOL/400; POLETLEN GLKOL-400; POLETLEN GLKOL 400; POLIETILEN GLIKOL 400; POLIETILEN GLIKOL400; POLIETILEN GLIKOL/400; POLIETILEN GLIKOL-400; pEG 400; PEG; PEG 400; peg400; peg-400; peg/400; peg400; PEG 400
PEG 400
Polyethylene glycol (PEG 400)
Polyethylene glycol (PEG 400)
Names
IUPAC name
Polyethylene glycol
Identifiers of PEG 400
CAS Number of PEG 400
25322-68-3 ☑
ChemSpider of PEG 400
none
Properties of PEG 400
Chemical formula of PEG 400 C2nH4n+2On+1, n = 8.2 to 9.1
Molar mass of PEG 400 380-420 g/mol
Density of PEG 400 1.128 g/cm3
Melting point of PEG 400 4 to 8 °C (39 to 46 °F; 277 to 281 K)
Viscosity of PEG 400 90.0 cSt at 25 °C, 7.3 cSt at 99 °C
Hazards of PEG 400
Flash point of PEG 400 238 °C (460 °F; 511 K)
Lethal dose or concentration (LD, LC):
LD50 (median dose) 30 mL/kg, orally in rats
PEG 400 (polyethylene glycol 400) is a low-molecular-weight grade of polyethylene glycol. PEG 400 is a clear, colorless, viscous liquid. Due in part to its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations.
Chemical properties of PEG 400
PEG 400 is strongly hydrophilic. The partition coefficient of PEG 400 between hexane and water is 0.000015 (log{displaystyle P=-4.8}{displaystyle P=-4.8}), indicating that when PEG 400 is mixed with water and hexane, there are only 15 parts of PEG400 in the hexane layer per 1 million parts of PEG 400 in the water layer.[1]
PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, and aromatic hydrocarbons, and is slightly soluble in aliphatic hydrocarbons.
Properties of PEG 400
Quality Leve of PEG 400l 200
vapor pressure of PEG 400 <0.1 hPa ( 20 °C)
autoignition temp. 360 °C (DIN 51794)
potency of PEG 400 28000 mg/kg LD50, oral (Rat)
>20000 mg/kg LD50, skin (Rabbit)
pH of PEG 400 5-7 (20 °C, 100 g/L in H2O)
kinematic viscosity of PEG 400 97-110 cSt(20 °C)
mp 5 °C
transition temp of PEG 400 flash point >200 °C
density of PEG 400 1.13 g/cm3 at 20 °C
InChI 1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
InChI key LYCAIKOWRPUZTN-UHFFFAOYSA-N
storage conditions Store below +30°C.
Show Fewer Properties
Description of PEG 400
Application of PEG 400
Polyethylene glycol 400 for synthesis. CAS of PEG 400 25322-68-3, pH 5 – 7 (100 g/l, H₂O, 20 °C).
Analysis Note
Density of PEG 400 (d 20 °C/ 4 °C): 1.124 – 1.126
Hydroxyl value of PEG 400: 267 – 295
Average molecular mass of PEG 400: 380 – 420
Identity of PEG 400 (IR): passes test
Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.
PEG 400
Excellent solvent for a large number of substances that do not readily dissolve in water
The low-molecular weight liquid polyethylene glycol PEG 400 is an excellent solvent for a large number of substances that do not readily dissolve in water. They are therefore widely used as solvents and solubilising agents for active substances and excipients in liquid and semi-solid preparations. It is the ability of PEGs to form complexes with active substances that is responsible for their excellent solvent power.
However, equilibrium constants for complex formation vary considerably from one substance to another, and certain drugs such as Penicillin G and Bacitracin can even become inactivated. The effect of the polyethylene glycol on the efficacy and absorbtion of a drug must therefore always be determined in tests. With regard to incompatible substances, please see the remarks in the European Pharmacopoeia, Vol. II/3, Monographs M1, Macrogol 300, p. 3. Polyethylene glycols can also be used to adjust the viscosity of liquid pharmaceutical preparations and ointments, to modify their absorption properties and to stabilise the preparation.
Why choose PEGs
Pharmaceutical grade IPEC GMP compliance
Versatile, water-miscible solvent vehicle for use in a multitude of drug formulations ranging from liquid and solid oral dosage forms to topical ointments and suppositories
Can be paired with BASF surfactants (for example Kolliphor® RH 40) to promote solubilization of poorly water-soluble APIs
May be formulated with BASF polymers (for example Kollidon® 12 PF) for crystallization inhibition
Combine low and high molecular weight PEG excipients to customize a waterwashable formulation base for topical ointments
Can also be used as a chemical intermediate in drug formulation
Product Details
Chemical name of PEG 400: Polyethylene glycol
Trivial names of PEG 400: Polyethylene glycol, macrogol, polyglycol, polyoxyethylene and polydiol
Former tradename of PEG 400: Lutrol® E 400
CAS-No of PEG 400: 25322-68-3
INCI of PEG 400: PEG-8
Regulatory Status of PEG 400: PEG 400 meets the requirements of the current monograph for Macrogol in Ph. Eur., Polyethyleneglycol in USP/NF and Polyethyleneglycol in JP.
Applications of PEG 400: The product is mainly applied as solvent for oral and topical preparations.
Description of PEG 400: PEG 400 is colourless, almost odourless and tasteless liquids at room temperature. The products are manufactured by alkali-catalysed polymerisation of ethylene oxide with subsequent neutralisation of the catalyst.
Solubility of PEG 400:
PEG 400 is readily soluble in water, ethanol, acetone, glycols and chloroform
insoluble in ether, paraffin, oils and fats
DESCRIPTION
PEG 400 is water-soluble, nonionic, relatively inert, liquids or solids. Confers slip and humectant properties to coatings. See poly(ethylene oxide) for higher molecular weights. The terms poly(ethylene glycol) and poly(ethylene oxide) refer to polymers which are chemically identical. Polymer chains are hydroxyl-terminated at both ends. At all except the lowest molecular weights poly(ethylene glycol) has a broad molecular weight distribution ranging from ~ 0.5x to 1.5x the values shown.
Soluble in: alcohol, acetone, chloroform, toluene, dichloromethane
CAS# of PEG 400: 25322-68-3
Formula of PEG 400: H(OCH2CH2)nOH
Molecular Weightv: 400
Melting Point of PEG 400: 4-8
Tg of PEG 400: -41°
Refractive Index of PEG 400: n20/D 1.4563
Viscosity of PEG 400: 7.3 cps @ 100°C
Appearance of PEG 400: viscous liquid
Hazards of PEG 400: Harmless-use normal precautions
Handling of PEG 400: Exercise normal care
Storage of PEG 400: Store at room temperature
IDENTIFICATION
Name
Polyethylene glycol 400
Accession Number
DB11077
Description
Polyethylene glycols (PEGs) are products made of condensed ethylene oxide and water that can contain various derivatives and have various functions. Because many PEG types are hydrophilic, they are favorably used as enhancers of penetration, and used heavily in topical dermatological preparations. PEGs, along with their many nonionic derivatives, are widely utilized in cosmetic products as surfactants, emulsifiers, cleansing agents, humectants, and skin conditioners.9
Polyethylene glycol 400 (PEG 400) is a low-molecular-weight grade of polyethylene glycol with a low-level toxicity. It is very hydrophilic, which renders it a useful ingredient in drug formulations to augment the solubility and bioavailability of weakly water-soluble drugs. PEG 400 is used in ophthalmic solutions for the relief of burning, irritation and/or discomfort that follows dryness of the eye 7. PEG 400 indicates that the average molecular weight of the specific PEG is 400 10.
PEGylation occurs when PEGs are attached to numerous protein medications, allowing for greater solubility for selected drugs. Examples of PEGylated medications are PEG-interferon alpha (Pegintron) and PEG-filgrastim. In addition, PEG 400 is available as a bowel preparation for colonoscopy procedures and as a laxative 10.
Type
Small Molecule
Groups
Approved
Synonyms
Octaethylene glycol
PEG-400
PEG-8
Polyethylene glycol 400
Polyethylene glycol 8
PHARMACOLOGY
Indication
PEG 400 has been indicated for the temporary relief of burning and irritation due to dryness of the eye, and for protection against further irritation and desiccation 14, 15, 16.
Pharmacodynamics
PEG 400, when used as PEG-400 for eye lubrication provides relief of dry eye symptoms and prevents further irritation, thus protecting the eye from injury 15. PEG allows comfortable eye drop/natural tear instillation by offering improved spreading of the drop over the ocular surface with diminished blurring 14,15.
Mechanism of action
PEG 400, depending on molecular weight, has various mechanisms of action 4, 5, 6, 7. For the purpose of Peg 400, the mechanism of action on the eye tissues will be the primary focus of discussion.
PEG 400 is considered a lacrimomimetic, or a synthetic ocular lubricant that improves one or more components of the lacrimal film by augmenting the tear volume and stability and by protecting the eye surface against desiccation 16. Hydroxypropyl-guar (HPG) is used along with polyethylene glycol 400 (PEG 400 ) and propylene glycol (PG) as a gelling agent that conforms to abnormalities of the tear film and existing irregularities on the ocular surface 16.
PEG 400 provides lubrication and acts as a surfactant by coating the eye and interacting with propylene glycol and other solutions that help to act as surfactants on the eye mucosa 15. This allows for long-lasting, soothing effects 15.
Recent studies involving nanoparticle drug delivery have demonstrated that PEG can achieve sustained drug delivery. The delivery of drugs to mucosal surfaces is a significant challenge due to the presence of the protective mucus layer that acts to trap and quickly remove foreign particles. Nanoparticles designed to rapidly cross mucosal barriers (mucus-penetrating particles, “MPP”) have proven promising for augmenting drug distribution, and efficacy at various mucosal surfaces. Mucus- penetrating particles are heavily coated with polyethylene glycol (PEG), protecting the nanoparticle core from adhesion with mucus 17.
Polyethylene glycol PEG 400, when free in solution, may also demonstrate attraction to the surfaces of various types of vesicles, cells or macromolecules, leading to polymer adsorption and subsequently either a repulsion or to an attraction, via bridging, of the surfaces or vesicles-again strongly depending on the temperature, molecular weight, and concentration of the polyethylene glycol. Low molecular weight polyethylene glycol (such as PEG 400) generally promotes cells or vesicles to adhere (depletion attraction), high molecular weight polyethylene glycol causes them to repel
PEG 400
PEG 400 Teknik Özellikleri
HO(C2H4O)nH
M = 280-420 g/mol
PEG 400 Erime: 5-6 °C
PEG 400 Kaynama: >220 °C
PEG 400 CAS [25322-68-3]
UN
PEG 400 EC 500-038-2
PEG 400 SINIFI : TEHLKEL
PEG 400 PARAMETRELER SPESFKASYON DEERLER
PEG 400 Younluk (20 C)
: 1,11-1,14 gr/cm³
PEG 400 Ort.Molekül Arl
: 380-420 gr/mol
PEG 400 Hidroksil Deeri
: 264-300 mg KOH/gr
PEG 400 1,4-Dioksan
: <= 10 ppm
PEG 400 Toplam Glikoller
: <= 0,2 %
PEG 400 Etilen Oksit
: <= 1,0 ppm
PEG 400 Asidite
: <= 0,1 mg KOH/gr
PEG 400 Renk(Pt-Co)
: <= 20
PEG 400 Su(K.F)
: <= 0,1%
PEG 400pH( 10 %,H2O,20 C)
: 4,0-7,0
PEG 400 Kinetik Viskozite(20 C)
: 95-111 mm2/s
PEG 400 Dinamik Viskozite(20 C)
: 110-125 mPa.s
PEG 400
PEG 400 ün Toksikolojisi düüktür. PEG 400 Deterjan ve endüstriyel sektöründe oldukça kullanlr. Noniyonik özellikte, temizleyici, kvamlatrc ve emülgatör özelliinden dolay PEG 400 kullanlr.Plastik sektöründe yumuatc olarak kullanlmakla beraber kozmetik sektöründe katk maddesi olarak PEG 400 kullanlr. Ayrca çeitli yüzeylerde yalayc olarak kullanlr. zin verilen miktarda gda sektöründe de PEG 400 kullanm mevcuttur.
PEG 400 Cas No 25322-68-3
PEG 400 EINECS No 500-038-2
PEG 400 Kimyasal Formülü H(OCH2CH2)nOH
PEG 400 Görünüm RENKSZ SIVI
PEG 400 Saflk(%) 100 %
PEG 400 Younluk (Kg/Litre) –
PEG 400 Parlama Noktas, °C 227°C AÇIK – 263°C KAPALI
PEG 400 Kaynama Noktas, °C > 200 °C HESAPLANAN BOZUNMASI
PEG 400 Asitik Deer(%) Açklama yaplacak olan alan
PEG 400 Molekül Arl 400 (380 – 420) g/mol
PEG 400 Eanlaml Kelimeler POLETLEN GLKOL 400
PEG 400
PEG 400
ÜRÜN AÇIKLAMASI:
Mineral ya, tekstil, deri, metal ve deterjan sanayilerinde, wax, parafin ve çözgen emülsiyonlarnda emülgatör, ara çözücü, viskosite ayarlayc, nemlendirici, ester üretiminde alkol komponenti olarak kullanlmaktadr.
Kullanm alan ve Tanm
PEG 200-300-PEG 400-600; mineral ya, tekstil, deri, metal ve deterjan sanayilerinde, wax, parafin ve çözgen emülsiyonlarnda emülgatör, ara çözücü, viskosite ayarlayc, nemlendirici, ester üretiminde alkol komponenti olarak kullanlmaktadr. PEG 1000-1500-4000-6000-9000; çok çeitli sanayilerde emülgatör, yalayc ve kalp ayrc olarak kullanlmaktadr.
PEG 200, 300 ve 600 S 23 oC’de berrak renksiz svlardr. PEG 600, ortam scaklna bal olarak berrak-renksiz bir sv, süt beyaz sv veya bir yar kat kararllna sahip olabilir. Ca.1000 yada daha fazla molar kütleli polietilen glikoller 23 oC’de katdrlar.
PEG 400 çeitlerinin yalar, ya asitleri, alkoller ve sv yalarla, doal ve sentetik ester ve hidrokarbon waxlar, petrol fraksiyonlar ve hidrofobik bir doann dier maddelerinin çouyla karabilirlii snrldr.
Bununla birlikte, sözde karmlar veya hamur kvamnda dalmlar, ürünlerin birkaç kombinasyonlaryla, onlar bir kabn içinde eriterek veya karmadan önce soumalarna izin vererek yaplabilir.
Kromatik pigmentler, sermik pigmentler ve cilalar, kat yalarda andrclar gibi katlar PEG çeitleriyle kararl-homojen hamurlara temellendirilebilirler. PEG katlarn doru bir ekilde nemlendirilmesini, viskositenin makul limitlerde tutulmasn ve çeitli malzememlerin doru bir ekilde oranlandrlmasn salar.
PEG 400 çeitleri, suda çözünür polieter alkollerdir. Çözücüler, yalayclar ve datclar olarak çeitli uygulamalarda kullanlrlar. Ayrca likitlerin viskositesini modifiye etmek için kullanlabilirler ve s transfer ve hidrolik svlar olarak kullanlabilirler. Polietilen glikoller ayrca organik sentezlerde ara madde olarak kullanlrlar.
PEG 200,PEG 300,PEG 400 ve PEG 600 sulu formülasyonlarda yüzey aktif karmlarn çözmek için temizleyici endüstrisinde ve deterjanlarda kullanlrlar. PEG çeitleri, yüksek solvent gücüne ve pigment ve boyalarn bir çoklar için datc kapasiteye sahiptir ve bazik boyalar ve baz boya bazlar için etkili çözücülerdir. Yüksek kapatlckla mürekkepleri formüle etmek için ofis tedarik endüstrisinde kullanlrlar. Mürekkebin younluu kat ve sv PEG çeitlerinin karm kullanlarak kontrol altna alnabilir. PEG çeitleri fleksografik mürekkeplerde bazik boyalar için solventler olarak kullanlabilirler. Benzer bir ekilde, sv ve hamur pigment preparatlar, tekstilde hamur koyulatrclar, boya ve saramik endüstrisinde çözücü ve datc ortam olarak kullanlabilirler.
PEG 400 Görünümü : Beyaz
PEG 400 Kimyasal Ad : Polyethylene Glycols / PEG
PEG 400 Kimyasal Formül : C2nH4n+2On+1
PEG 400 Ambalaj ekli : Varillerde – Torbalarda
PEG 400 Tanm ve Kullanm Alanlar :
Polietilen glikol üretimi ilk kez 1859 ylnda bildirildi. Hem AV Laurence hem de Charles Adolphe Wurtz, ürünleri polietilen glikollerle bamsz olarak izole etti. Polietilen glikol, etilen oksit, su, etilen glikol veya etilen glikol oligomerleri ile etkileim yoluyla üretilir. Reaksiyon asidik veya bazik katalizörler ile katalize edilir. Düük polidispersite (dar molekül arl dalm) olan polimerlerin üretilmesine izin verdiklerinden, etilen glikol ve bunun oligomerleri, su yerine bir balangç malzemesi olarak tercih edilir. Polimer zincir uzunluu, reaktanlarn oranna baldr.
HOCH 2 , CH 2 , OH + n (CH 2 CH 2 O) → HO (CH 2 CH 2 O) n + 1 ‘H
Katalizörün niteliine bal olarak, polimerizasyon mekanizmas katyonik veya anyonik olabilir. Anyonik mekanizma tercih edilir çünkü düük polidispersite ile PEG 400 elde edilebilir. Etilen oksit polimerizasyonu egzotermik bir ilemdir. Ar snma veya etilen oksitin alkaliler veya metal oksitler gibi katalizörlerle kirlenmesi, birkaç saat sonra patlamaya neden olabilecek ar polimerlemeye neden olabilir.
Polietilen oksit veya yüksek molekül arlkl polietilen glikol süspansiyon polimerizasyonu ile sentezlenir. Çoklu younlama ilemi boyunca büyüyen polimer zincirinin çözeltide tutulmas gereklidir. Reaksiyon, magnezyum, alüminyum veya kalsiyum organoelement bileikleri ile katalize edilir. Dimetilgloksim gibi krpma katklar, polimer zincirlerinin çözülmesini önlemek için kullanlr.
Alkalin katalizörler, sodyum hidroksit (NaOH), potasyum hidroksit (KOH) veya sodyum karbonat (Na2C03) gibi düük molekül arlkl bir polietilen glikol hazrlamak için kullanlr.
PEG 400 Kullanm Alanlar
PEG 400 hidrofilik molekül olduundan, tek moleküllü flüoresans çalmalarnda proteinlerin spesifik olmayan yapmasn önlemek için mikroskop cam slaytlarn pasifletirmek için kullanlr.
Polietilen glikol, toksisitesi düüktür ve çeitli ürünlerde kullanlr.
Polimer, sulu ve sulu olmayan ortamlarda çeitli yüzeyler için yalayc bir kaplama olarak kullanlr.
PEG 400, esnek, suda çözünür bir polimer olduundan, çok yüksek ozmotik basnçlaroluturmak için kullanlabilir.
Polietilen glikol, gaz kromatografisi için polar duraan bir fazn yan sra elektronik test cihazlarnda bir s transfer svs olarak yaygn olarak kullanlr .
PEG 400, kütle spektrometri deneylerinde, doru ve tekrarlanabilir ayarlamaya izin veren karakteristik parçalanma modeliyle sklkla kullanlr.
Dar alanl etoksilatlar gibi PEG türevleri yüzey aktif maddeler olarak kullanlr .
PEG 400 baz polimerler oluturmak için kullanlan amfifilik blok kopolimerlerin hidrofilik blou olarak kullanlmtr .
PEG 400 bir dizi müshilatin temelidir . Polietilen glikol ve ilave elektrolitler ile tüm barsak sulama , cerrahi veya kolonoskopi öncesi barsak hazrl için kullanlr .
PEG birçok farmasötik ürünlerde bir eksipiyan olarak da kullanlr .
Çeitli protein ilaçlarna balandnda , polietilen glikol, tanan proteinin kandaki yavalatlmasna izin verir.
PEG 400, oldukça kalabalk hücresel koullar taklit etmek için in vitro deneylerde yaygn olarak kalabalk ajan olarak kullanlr.
PEG 400, yaygn olarak plazmid DNA izolasyonu ve protein kristallemesi için bir çökelti maddesi olarak kullanlr . Protein kristallerinin X-n krnm , proteinlerin atomik yapsn ortaya çkarabilir.
PEG 400, hibridomalar oluturmak için iki farkl hücrenin tipini, çounlukla B-hücrelerini ve miyelomalarn kaynatrmak için kullanlr .
PEG 400 poliollerinden türetilmi polimer parçalar , elastomerik elyaflar ( spandex ) ve köpük yastklar gibi uygulamalar için poliüretanlara esneklik kazandrr .
Olarak mikrobiyoloji , PEG çökeltme virüsleri konsantre etmek için kullanlr.
Gen terapi vektörleri (virüsler gibi) PEG 400 ile kaplanarak baklk sistemi tarafndan inaktivasyona uramaktan korunur ve onlar organlardan uzaklatrp toksik etki gösterebilecekleri yerlerden hedef alnmasn önleyebilir.
Nitrat esteri -plastikletirilmi polietilen glikol Trident II denizalt frlatmal balistik füze kat roket yaktnda kullanlr.
PEG 400’in dimetil eterleri , gaz atk akndan karbondioksit ve hidrojen sülfidi çkarmak için kömür yanmas, entegre gazlatrma kombine çevrim (IGCC) santralleri tarafndan kullanlan bir çözücü olan Selexol’ün temel bileenidir .
PEG 400, bir yaltkanda süperiletkenlii indüklemek için bir elektrikli çift katmanl transistörde kap izolatörü olarak kullanlmtr.
PEG 400 ayrca kat polimer elektrolitleri için bir polimer konakç olarak kullanlr. Henüz ticari üretimde olmamasna ramen, dünyadaki pek çok grup, özelliklerini gelitirmeyi ve piller, elektrokromik görüntü sistemleri ve dier ürünlerdeki dier ürünlerin kullanmna izin vermek amacyla PEG 400 içeren kat polimer elektrolitleri üzerine aratrmalar yapmaktadr. gelecei.
Ayrma ekipmannda köpürmeyi azaltmak için endüstriyel proseslere PEG enjekte edilir.
PEG 400, teknik seramiklerin hazrlanmasnda bir balayc olarak kullanlr .
PEG 400 birçok cilt kremlerinin ( cetomakrogol olarak ) ve kiisel yalayclarn (sklkla gliserin ile kombine edilen ) temelidir .
PEG 400, bir dizi di macununda bir dispersan olarak kullanlr . Bu uygulamada, su balar ve ksantan sakznn di macunu boyunca eit dalmda kalmasna yardmc olur .
PEG 400, vücut zrhnda ve eker hastaln izlemek için kullanlan dövmelerde de aratrlyor .
Düük molekül arlkl formülasyonlarda (örn. PEG 400 ), bask kafalar için bir mürekkep solventi ve yalayc olarak Hewlett-Packard tasarm jeti yazclarnda kullanlr .
PEG 400
Polyéthylène glycol
Polyéthylène glycol
Des noms
Nom IUPAC
Polyéthylène glycol
Identifiants
Numero CAS
25322-68-3 ☑
ChemSpider
aucun
Propriétés
Formule chimique C 2n H 4n + 2 O n + 1 , n = 8,2 à 9,1
Masse molaire 380 à 420 g / mol
Densité 1,128 g / cm 3
Point de fusion 4 à 8 ° C (39 à 46 ° F; 277 à 281 K)
Viscosité 90,0 cSt à 25 ° C, 7,3 cSt à 99 ° C
Dangers
point de rupture 238 ° C (460 ° F; 511 K)
Dose ou concentration létale (DL, LC):
DL 50 ( dose médiane ) 30 mL / kg, par voie orale chez le rat
Le PEG 400 (polyéthylène glycol 400) est une qualité de polyéthylène glycol de faible poids moléculaire . C’est un liquide clair, incolore et visqueux. En partie en raison de sa faible toxicité, le PEG 400 est largement utilisé dans une variété de formulations pharmaceutiques.
Propriétés chimiques
Le PEG 400 est fortement hydrophile . Le coefficient de partage du PEG 400 entre l’hexane et l’eau est de 0,000015 (log{ displaystyle P = -4,8}{ displaystyle P = -4,8}), indiquant que lorsque le PEG 400 est mélangé avec de l’eau et de l’hexane, il n’y a que 15 parties de PEG400 dans la couche d’hexane pour 1 million de parties de PEG 400 dans la couche d’eau. [1]
Le PEG 400 est soluble dans l’eau, l’acétone, les alcools, le benzène, la glycérine, les glycols et les hydrocarbures aromatiques, et est légèrement soluble dans les hydrocarbures aliphatiques.
Polyethylene glycol 400 (PEG 400)
(P-034)
Les résultats de votre test cutané indiquent que vous avez une allergie de contact
au Polyethylene glycol 400 (PEG 400) Il est important de vous familiariser avec ce
produit chimique et de prendre des mesures pour éviter tout contact avec ce dernier.
Qu’est-ce que le Polyethylene glycol 400 (PEG 400) et où le trouve-t-on?
Ce produit est utilisé pour fabriquer des émulsifiants et des détergents et comme
plastifiants, humidifiants et lubrifiants textiles solubles dans l’eau. Le large éventail de
longueurs de chaîne fournit des propriétés physiques et chimiques identiques pour des
sélections d’application appropriées directement ou indirectement dans le domaine de la
préparation de résine d’alkyde et de polyester pour améliorer la dispersabilité de l’eau et
des enduits à base d’eau. Il s’agit d’un agent anti-poussière utilisé dans les formules
agricoles dont l’effet d’éclaircissement et l’adhésion s’améliorent dans la galvanoplastie.
Nettoyants, détergents et savons avec des propriétés de solvant à forte volatilité et à
toxicité faible ; agent de couplage, humidifiant, solvant et lubrifiant dans les bases de
cosmétiques et de produits pour les soins personnels ; stabilisateur dimensionnel dans
des activités de travail du bois ; support de teinture dans les peintures et les encres ;
formule de fluide de transfert de chaleur et formules antimousse. Volatilité basse, soluble
dans l’eau et lubrifiant résistant à la corrosion sans résidu de coloration dans les
aliments et l’emballage. Agent de démoulage et lubrifiant dans la fabrication des
élastomères ; couchage du papier pour la propriété anticollante, la stabilisation des
couleurs, la bonne brillance et le débit libre du calandrage ; plastifiant pour augmenter le
glissement et communiquer une propriété d’humidifant dans le mélange liquide
céramique, les adhésifs et les liants ; agent adoucissant et antistatique pour les étoffes.
Décapant avec bonne propriété d’étalement. Le glycol polyéthylénique est non-toxique,
inodore, neutre, lubrifiant, non-volatile et non irritant et est utilisé dans divers
médicaments comme solvant, agent dispersant, onguent, excipient et excipient pour
suppositoires et pour tablettes.
Quelles sont les autres appellations du Polyethylene glycol 400 (PEG 400)?
PEG 400 chimique peut apparaître sous différents noms, y compris : Polyethylene oxide (PEO); Methoxypolyethylene glycol
(mPEG); Some commercial names (trademarks) include Carbowax and Carbowax Sentry, Alcox, Breox, Lutrol. Some medical
and consumer brand names include MiraLAX, GoLYTELY, Fortrans, TriLyte, SoftLax
PEG 400
N° CAS of Peg 400 : 25322-68-3
“Pas terrible” dans toutes les catégories.
Origine(s) du Peg 400 : Synthétique
Nom INCI du Peg 400 : PEG-400
Additif alimentaire du Peg 400 : E1521
Classification du Peg 400: PEG/PPG, Composé éthoxylé, Glycol, Polymère de synthèse
Ses fonctions (INCI)
Agent fixant du Peg 400 : Permet la cohésion de différents ingrédients cosmétiques
Stabilisateur d’émulsion du PEG 400 : Favorise le processus d’émulsification et améliore la stabilité et la durée de conservation de l’émulsion
Solvant du Peg 400: Dissout d’autres substance.
Peg 400 est présent dans 0.09% des cosmétiques.