VITAMIN B3 (NIACINAMIDE)
Vitamin B3 (Niacinamide) supports skin health by regulating oil production, reducing inflammation, and improving the appearance of dark spots and fine lines.
As a water-soluble vitamin, Vitamin B3 (Niacinamide) is involved in energy metabolism, DNA repair, and maintaining healthy cells, but it is not stored in the body and excess amounts are excreted in urine.
Vitamin B3 (Niacinamide) is found in foods like meat, fish, and cereals, and can also be taken as a supplement to help manage conditions like pellagra and support cardiovascular health.
CAS Number: 59-67-6
EC Number: 200-441-0
Molecular Formula: C6H5NO2
Molecular Weight: 123.11
Synonyms: nicotinamide, niacinamide, 98-92-0, 3-Pyridinecarboxamide, Nicotinic acid amide, pyridine-3-carboxamide, vitamin PP, Aminicotin, Amixicotyn, Papulex, Nicotylamide, Endobion, Hansamid, Nicobion, Nikotinamid, Savacotyl, Benicot, Dipegyl, Pelmine, Nicotinic amide, Delonin amide, Pelonin amide, Austrovit PP, Vi-Nicotyl, Inovitan PP, Amnicotin, Nicamindon, Nicomidol, Nicosylamide, Nicotamide, Nicotilamide, Nicotililamido, Nicovitina, Nicovitol, Nicozymin, Niocinamide, Niacevit, Niamide, Nicamina, Nicasir, Nicofort, Nicogen, Nicotol, Nicovit, Niozymin, Nicota, Niko-tamin, 3-Carbamoylpyridine, Nandervit-N, Nicotinamidum, Niavit PP, Nicosan 2, Nicotine amide, Nicotine acid amide, Nikotinsaeureamid, Pyridine-3-carboxylic acid amide, Vitamin B, Nicotylamidum, Nicotinsaureamid, beta-Pyridinecarboxamide, Pyridine, 3-carbamoyl-, Mediatric, Factor pp, m-(Aminocarbonyl)pyridine, 3-Pyridinecarboxylic acid amide, Nicotinamida, Pelmin, Acid amide, Witamina PP, PP-Faktor, Amid kyseliny nikotinove, Amid PP, 3-(aminocarbonyl)pyridine, Dipigyl, Niacinamid, Nicovel, Vitamin B (VAN), CCRIS 1901, Nicotinsaureamid [German], NAM, HSDB 1237, Nikotinsaeureamid [German], Amid kyseliny nikotinove [Czech], Nicotinamidum [INN-Latin], Nicotinamida [INN-Spanish], AI3-02906, NSC 13128, Nicotinamid, Nictoamide, Nicotinsaeureamid, 3-Amidopyridine, Vi-noctyl, EINECS 202-713-4, NSC-13128, NSC-27452, b-Pyridinecarboxamide, Niacinamide (USP), Niacinamide [USP], UNII-25X51I8RD4, Nicotinamide [INN], DTXSID2020929, CHEBI:17154, 25X51I8RD4, Nicotinamide (Standard), NSC13128, MFCD00006395, .beta.-Pyridinecarboxamide, Nicotinamide-(amide-15N), Nicotinamide (Vitamin B3), CHEMBL1140, DTXCID00929, MLS000069714, TPN COMPONENT NIACINAMIDE, EC 202-713-4, NIACINAMIDE COMPONENT OF TPN, NSC27452, NCGC00093354-03, NCGC00093354-05, SMR000058212, Nicotinamide 10 microg/mL in Acetonitrile, NIACINAMIDE (II), NIACINAMIDE [II], Niacinamide;Nicotinic acid amide;Vitamin B3, WLN: T6NJ CVZ, Nicotinamidum (INN-Latin), Nicotinamida (INN-Spanish), NIACINAMIDE (USP-RS), NIACINAMIDE [USP-RS], NICOTINAMIDE (MART.), NICOTINAMIDE [MART.], 3 Pyridinecarboxamide, Niacinamide [USAN], NICOTINAMIDE (EP IMPURITY), NICOTINAMIDE [EP IMPURITY], NIACINAMIDE (USP MONOGRAPH), NIACINAMIDE [USP MONOGRAPH], NICOTINAMIDE (EP MONOGRAPH), NICOTINAMIDE [EP MONOGRAPH], CAS-98-92-0, SR-01000721872, Niacotinamide, Nicosedine, Nicamid, nicotin-amide, Pahaba Control, Ultra Whitening, CellExosome HR, CellExosome SB, DEA No. 1405, Celonia CM, Ginseng Whitening, Dr. Cellmo, Royal GinsengCream, TOAS Rejuvenation, Nicotinamide,(S), Vitamin B3 amide, Costem cell 5 N, Royal GinsengLotion, AAPE Skin Ampoule, CellExosome HE HR, Fantastic LightCream, Royal Ginseng Toner, Vita C Bright Serum, Vita C Bright Toner, Niacinamide Face Mask, Royal Ginseng Essence, Ultra V AQUA SHINE MASK, Ultra Whitening First Essence, NICOTINAMIDE [WHO-DD], NICOTINAMIDE [WHO-IP], by selected hyaluron day serum, Dr Cellinme Mask Sheet, Opera_ID_775, Vita C Bright EyeCream, Miracle Laser Skin Mist, Niacin (as niacinamide), Pyridine-3-carboxylamide, APLIN SPOT REMOVER, KARATICA I M CURE, NIACINAMIDE [FCC], NICOTINAMIDE [MI], NICOTINAMIDE [INCI], NICOTINAMIDE [JAN], NYAAM NYAAM Vita Serum, EINECS 202-713-4, NSC-13128, NSC-27452, b-Pyridinecarboxamide, Niacinamide (USP), Niacinamide [USP], UNII-25X51
Vitamin B3 (Niacinamide) is a form of vitamin B3 made in the body from tryptophan.
Vitamin B3 (Niacinamide) also may help regulate the amount of oil glands produce, which can prevent breakouts and clogged pores.
Some research suggests skin care formulas with 5% Vitamin B3 (Niacinamide) can also help lighten dark spots.
Vitamin B3 (Niacinamide)’s found in many foods including meat, fish, milk, eggs, green vegetables, and cereals.
Vitamin B3 (Niacinamide) is required for the proper function of fats and sugars in the body and to maintain healthy cells.
At high doses, Vitamin B3 (Niacinamide) might help people with heart disease because of its effects on blood clotting.
Vitamin B3 (Niacinamide) might also improve levels of fats called triglycerides in the blood.
Vitamin B3 (Niacinamide) is a form of vitamin B3.1 “Vitamin B3” can mean nicotinamide or nicotinic acid (niacin).
Some companies may label Vitamin B3 (Niacinamide) and nicotinic acid as “niacin.”
However, niacin and Vitamin B3 (Niacinamide) are different forms of vitamin B3. They have different chemical structures that work differently in your body.
For example, Vitamin B3 (Niacinamide) doesn’t reduce cholesterol levels like niacin.
Vitamin B3 (Niacinamide) is a water-soluble vitamin, meaning it’s not stored in the body.
Vitamin B3 (Niacinamide) is one form of vitamin B3 (niacin) that plays an important role in energy metabolism and cell health.
Vitamin B3 (Niacinamide) may offer benefits related to skin care and skin cancer, as well as chronic kidney disease and type 1 diabetes.
Vitamin B3 (Niacinamide) was discovered by the oxidation of nicotine.
Vitamin B3 (Niacinamide) is derived from nicotinic acid + vitamin, as the name to be given to it is not intended to evoke nicotine.
Vitamin B3 (Niacinamide) helps keep your nervous system, digestive system and skin healthy.
Vitamin B3 (Niacinamide) is often part of a daily multivitamin, but most people get enough niacin from the food they eat.
Foods rich in Vitamin B3 (Niacinamide) include yeast, milk, meat, tortillas and cereal grains.
People use prescription Vitamin B3 (Niacinamide) (Niacor, Niaspan) to help control their cholesterol.
The recommended daily amount of Vitamin B3 (Niacinamide) for adult males is 16 milligrams (mg) a day and for adult women who aren’t pregnant, 14 mg a day.
Vitamin B3 (Niacinamide), is a water-soluble B vitamin found naturally in some foods, added to foods, and sold as a supplement.
The two most common forms of Vitamin B3 (Niacinamide) in food and supplements are nicotinic acid and nicotinamide.
The body can also convert tryptophan—an amino acid—to Vitamin B3 (Niacinamide).
Vitamin B3 (Niacinamide) is water-soluble so that excess amounts the body does not need are excreted in the urine.
Vitamin B3 (Niacinamide) works in the body as a coenzyme, with more than 400 enzymes dependent on it for various reactions.
Vitamin B3 (Niacinamide) helps to convert nutrients into energy, create cholesterol and fats, create and repair DNA, and exert antioxidant effects.
Vitamin B3 (Niacinamide) is one of the two forms of vitamin B3 — the other being nicotinic acid.
Vitamin B3 (Niacinamide) is also known as niacin.
Vitamin B3 (Niacinamide) and nicotinic acid both provide vitamin B3 activity, but they differ in chemical structure and how they affect your health.
This article explains what Vitamin B3 (Niacinamide) is, its benefits, uses and potential side effects.
Vitamin B3 (Niacinamide), colloquially referred to as niacin, is a vitamin family that includes three forms, or vitamers: niacin (nicotinic acid), nicotinamide (niacinamide), and nicotinamide riboside.
All three forms of Vitamin B3 (Niacinamide) are converted within the body to nicotinamide adenine dinucleotide (NAD).
Vitamin B3 (Niacinamide) is required for human life and people are unable to make it within their bodies without either vitamin B3 or tryptophan.
Vitamin B3 (Niacinamide) riboside was identified as a form of vitamin B3 in 2004.
Vitamin B3 (Niacinamide) can be manufactured by plants and animals from the amino acid tryptophan.
Vitamin B3 (Niacinamide) is obtained in the diet from a variety of whole and processed foods, with highest contents in fortified packaged foods, meat, poultry, red fish such as tuna and salmon, lesser amounts in nuts, legumes and seeds.
Vitamin B3 (Niacinamide) as a dietary supplement is used to treat pellagra, a disease caused by niacin deficiency.
Signs and symptoms of pellagra include skin and mouth lesions, anemia, headaches, and tiredness.
Many countries mandate Vitamin B3 (Niacinamide)’s addition to wheat flour or other food grains, thereby reducing the risk of pellagra.
The amide Vitamin B3 (Niacinamide) is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP+).
Although niacin and Vitamin B3 (Niacinamide) are identical in their vitamin activity, nicotinamide does not have the same pharmacological, lipid-modifying effects or side effects as niacin, i.e., when niacin takes on the -amide group, Vitamin B3 (Niacinamide) does not reduce cholesterol nor cause flushing.
Vitamin B3 (Niacinamide) is recommended as a treatment for niacin deficiency because Vitamin B3 (Niacinamide) can be administered in remedial amounts without causing the flushing, considered an adverse effect.
In the past, the group was loosely referred to as vitamin B3 complex.
Vitamin B3 (Niacinamide) naturally found in food is susceptible to destruction from high heat cooking, especially in the presence of acidic foods and sauces.
Vitamin B3 (Niacinamide) is soluble in water, and so may also be lost from foods boiled in water.
Vitamin B3 (Niacinamide) deficiency is rarely seen in developed countries, and Vitamin B3 (Niacinamide) is more typically associated with poverty, malnutrition or malnutrition secondary to chronic alcoholism.
Vitamin B3 (Niacinamide) also tends to occur in areas where people eat maize (corn) as a staple food, as maize is low in digestible niacin.
A cooking technique called nixtamalization, that is, pretreating with alkali ingredients, increases the bioavailability of niacin during maize meal or flour production.
Vitamin B3 (Niacinamide), also known as nicotinic acid amide, is the water-soluble, active form of vitamin B3.
Vitamin B3 (Niacinamide) has been increasingly studied for many different indications in the field of dermatology, but more research is needed to clarify its value.
Vitamin B3 (Niacinamide) is naturally present in small quantities in yeast, lean meats, fish, nuts and legumes.
Vitamin B3 (Niacinamide) is also often added to cereals and other foods.
Oral Vitamin B3 (Niacinamide) is available as 20–30 mg in multivitamin combinations, and on its own as inexpensive 500-mg tablets.
Vitamin B3 (Niacinamide) has also been incorporated in many topical agents including sunscreens and cosmetic agents.
For this reason, people who consume corn as tortillas or hominy are at less risk of niacin deficiency.
Vitamin B3 (Niacinamide), or as us normal people call it vitamin B3, is a real skincare superstar that has had so many studies and has so many skin benefits that have to warn that this “geeky details” description will not be short.
Just as an intro a couple of thing about the stuff itself:
Vitamin B3 (Niacinamide)’s a water-soluble vitamin that usually comes in white powder form.
Vitamin B3 (Niacinamide) is odorless and has a salty, bitter taste.
Vitamin B3 (Niacinamide) can be found in meat, fish, wheat and small amounts in vegetables.
Vitamin B3 (Niacinamide) is the reaction with hydride ions (H?) that is the basis of the enzymatic hydrogen transfer by the pyridine nucleotides; the reaction involves the transfer of two electrons in a single step.
Several substituted pyridines are antagonists of Vitamin B3 (Niacinamide) in biological systems: pyridine-3-sulfonic acid, 3-acetylpyridine, isonicotinic acid hydrazine, 17 and 6-aminonicotinamide.
Vitamin B3 (Niacinamide) is involved in DNA repair processes, contributing to the maintenance of genetic stability within cells.
As a component of NAD, Vitamin B3 (Niacinamide) is involved in the proper functioning of the nervous system.
In each of these compounds, the electron-withdrawing effect of the N-1 atom and the amide group of the oxidized pyridine nucleus enables the pyridine C-4 atom to react with many nucleophilic agents (e.g., sulfite, cyanide, and hydride ions).
Vitamin B3 (Niacinamide) plays a role in neurotransmitter synthesis and nerve cell communication.
Vitamin B3 (Niacinamide) has been studied for its potential cardiovascular benefits, including its role in lipid metabolism.
Vitamin B3 (Niacinamide) may help lower levels of LDL (low-density lipoprotein) cholesterol and triglycerides while increasing HDL (high-density lipoprotein) cholesterol.
Some studies suggest that Vitamin B3 (Niacinamide) may have a role in supporting joint health, particularly in conditions like osteoarthritis.
Vitamin B3 (Niacinamide) exhibits anti-inflammatory properties, which may be beneficial in various conditions involving inflammation.
Through its role in NAD and NADP, Vitamin B3 (Niacinamide) participates in the energy production processes of the cell, aiding in the breakdown of carbohydrates, fats, and proteins for energy.
There is ongoing research exploring the potential links between Vitamin B3 (Niacinamide) and mental health, including its impact on conditions such as anxiety and depression.
Vitamin B3 (Niacinamide) is a water‑soluble vitamin that is not stored in the body.
Vitamin B3 (Niacinamide), also known as nicotinamide, refers to the amide derivative of niacin that is equivalent in vitamin activity.
Some texts use niacin to refer to Vitamin B3 (Niacinamide), and any derivatives with vitamin activity comparable to niacin.
Furthermore, research and chemistry-based resources use the terms Vitamin B3 (Niacinamide) and nicotinamide; whereas pharmacy resources use niacin and niacinamide.
Vitamin B3 (niacinamide) is the pyridine 3 carboxylic acid amide form of niacin.
Vitamin B3 (Niacinamide) is a precursor to nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are coenzymes involved in cellular metabolism.
The main source of vitamin in diet is in the form of nicotinamide, nicotinic acid, and tryptophan.
The main source of niacin include meat, liver, green leafy vegetables, wheat, oat, palm kernel oil, legumes, yeast, mushrooms, nuts, milk, fish, tea, and coffee.
The nicotinamide part of these two coenzyme structures in human body has reversible hydrogenation and dehydrogenation characteristics, Vitamin B3 (Niacinamide) plays a hydrogen transfer role in biological oxidation, can promote tissue respiration, biological oxidation process and metabolism, and is of great significance to maintain the integrity of normal tissues, especially skin, digestive tract and nervous system.
Vitamin B3 (Niacinamide) has been shown to have anti-inflammatory properties and can help improve the appearance of fine lines, wrinkles, and hyperpigmentation.
They play a critical role in the conversion of nutrients into energy.
Additionally, Vitamin B3 (Niacinamide) may be useful in managing certain skin conditions, such as acne and rosacea.
The skin flushing reaction produced by Vitamin B3 (Niacinamide) has been recognized for more than 70 years.
Vitamin B3 (Niacinamide) is a component of coenzyme I (nicotinamide adenine dinucleotide, NADP) and coenzyme II (nicotinamide adenine dinucleotide phosphate, NADP).
Vitamin B3 (Niacinamide) can be seen in ancient texts that the name vitamin PP (short for the English term “pellegra prevention”) was used for Nicotinic acid.
Vitamin B3 (Niacinamide) is a B vitamin that’s made and used by your body to turn food into energy.
The pH of 10% aqueous solution is 6.5-7.5. in dry air to light and heat stability, in alkaline or acidic solution, heating generation to Vitamin B3 (Niacinamide).
Vitamin B3 (Niacinamide) is frequently identified with the B complex vitamin grouping.
Early in the research on Vitamin B3 (Niacinamide), a nutritional niacin deficiency was identified as the cause of pellagra in humans, blacktongue in dogs, and certain forms of dermatosis in humans.
Vitamin B3 (Niacinamide) deficiency is also associated with perosis in chickens as well as poor feathering of the birds.
Vitamin B3 (Niacinamide) and nicotinamide are colorless crystalline substances.
Vitamin B3 (Niacinamide) is slightly soluble in water and ethanol; nicotinamide is very soluble in water and moderately soluble in ethanol.
Vitamin B3 (Niacinamide)s car boxyl group can form esters and anhydrides and can be reduced.
Both nicotinic acid and Vitamin B3 (Niacinamide) are very stable in dry form, but in solution nicotinamide is hydro lyzed by acids and bases to yield nicotinic.
The coenzyme forms of Vitamin B3 (Niacinamide) are the pyridine nucleotides, NAD(H) and NADP(H).
Vitamin B3 (Niacinamide) is a water-soluble nutrient that can help improve a variety of skin concerns.
Gaining popularity in the skincare industry due to its versatility and visible results, Vitamin B3 (Niacinamide) is a subsect of vitamin B3 and can be referred as two names interchangeably.
Read on to develop an understanding on how this important Vitamin B3 (Niacinamide) can be used to visibly enhance your skin for a softer, smoother and more balanced looking complexion.
Vitamin B3 (Niacinamide) is a multipurpose skin care ingredient.
Vitamin B3 (Niacinamide) helps build keratin, a protein that maintains skin health.
Vitamin B3 (Niacinamide) may enhance the function of skin’s lipid barrier (a layer of water and oil that protects your skin).
This helps lock moisture in and keep pollutants or other potential irritants out.
Vitamin B3 (Niacinamide) has been shown to ease inflammation, which can help calm redness due to conditions like acne, rosacea and eczema.
Vitamin B3 (Niacinamide) can also soothe irritation caused by strong exfoliants like retinol or glycolic acid.
Vitamin B3 (Niacinamide) can produce a variety of adverse effects, depending on the intake and health of the consumer.
Vitamin B3 (Niacinamide) is sometimes referred to as nicotinic acid or nicotinamide and earlier called the P-P factor, antipellagra factor, antiblacktongue factor, and vitamin B4, niacin is available in several forms for use as a nutrient and dietary supplement.
Vitamin B3 (Niacinamide), melting point is 234-237℃.
Vitamin B3 (Niacinamide) is slightly soluble in water and ethanol; 100ml room temperature water can dissolve 1.6g.
Vitamin B3 (Niacinamide) is often used in skincare products due to its beneficial effects on the skin.
Vitamin B3 (Niacinamide) was formerly called nicotinic acid; however, the term niacin is now preferred to avoid any confusion with the alkaloid, nicotine.
Vitamin B3 (Niacinamide) use of supplements containing niacin may be beneficial in terms of weight loss, as the substance will stimulate energy synthesis and help reduce the feeling of fatigue caused by weight loss.
Vitamin B3 (Niacinamide) also has positive effects on the health of the nervous system (Vitamin B3 (Niacinamide) triggers units related to cognitive functions and memory).
Vitamin B3 (Niacinamide) is water-soluble so that excess amounts the body does not need are excreted in the urine.
Vitamin B3 (Niacinamide) works in the body as a coenzyme, with more than 400 enzymes dependent on it for various reactions.
Vitamin B3 (Niacinamide) helps to convert nutrients into energy, create cholesterol and fats, create and repair DNA, and exert antioxidant effects.
Vitamin B3 (Niacinamide) is also a prescription medication.
Vitamin B3 (Niacinamide) is easily soluble in hot water, hot ethanol, alkaline water, propylene glycol, and chloroform.
Vitamin B3 (Niacinamide) is amphoteric and forms salts with acids as well as bases.
Vitamin B3 (Niacinamide) deficiency can cause serious symptoms such as muscle weakness, digestive upsets (irritation of the mucus layer in the mouth, stomach, and intestines), loss of appetite, and skin rashes.
In more severe cases, Vitamin B3 (Niacinamide) can cause lesions in the central nervous system, leading to confusion and disorientation.
Studies have shown that Vitamin B3 (Niacinamide) can significantly lower cholesterol levels, but because the product is inexpensive, the pharmaceutical industry has not commercialized this supplement as a combined treatment for hypercholesteremia.
Vitamin B3 (Niacinamide) helps regulate fat and cholesterol levels, Vitamin B3 (Niacinamide) can be used for the prevention or treatment of cardiovascular ailments.
Vitamin B3 (Niacinamide), also called nicotinic acid, water-soluble vitamin of the B complex.
Vitamin B3 (Niacinamide) is also called the pellagra-preventive vitamin because an adequate amount in the diet prevents pellagra, a chronic disease characterized by skin lesions, gastrointestinal disturbance, and nervous symptoms.
Vitamin B3 (Niacinamide) neutralize acids to form salts plus water.
These acid-base reactions are exothermic.
The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base.
Vitamin B3 (Niacinamide) amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.
Vitamin B3 (Niacinamide) flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Organic amides/imides react with azo and diazo compounds to generate toxic gases.
Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents.
Imides are less basic yet and in fact react with strong bases to form salts.
Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile.
Vitamin B3 (Niacinamide) is naturally present in many foods, added to some food products, and available as a dietary supplement.
Vitamin B3 (Niacinamide) is a pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
Vitamin B3 (Niacinamide), also known as Niacin, contributes to normal functioning of the nervous system, normal psychological function, maintenance of normal mucous membranes, skin, reduction of tiredness and fatigue, and normal energy-yielding metabolism.
Vitamin B3 (Niacinamide) is readily absorbed for maximum utilisation and benefit to the body.
Vitamin B3 (Niacinamide) filter solutions are filled and immediately fused under controlled conditions to become permanently airtight.
Vitamin B3 (Niacinamide) is a coenzyme involved in the production of energy through the citric acid cycle.
Vitamin B3 (Niacinamide) is used in combination with a healthy diet to lower bad cholesterol and increase good cholesterol.
Vitamin B3 (Niacinamide) is also used to decrease triglycerides.
Vitamin B3 (Niacinamide) can also be helpful in patients who have heart disease or who have had a heart attack.
Vitamin B3 (Niacinamide) may be used for other purposes; ask your health care provider or pharmacist if you have questions.
Vitamin B3 (Niacinamide) includes two vitamers giving rise to the coenzymatic forms nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP).
Vitamin B3 (Niacinamide) is an important cofactor in maintaining healthy psychological function.
Vitamin B3 (Niacinamide) has a role as an antidote, an antilipemic drug, a vasodilator agent, a metabolite, an EC 3.5.1.19 (nicotinamidase) inhibitor, an Escherichia coli metabolite, a mouse metabolite, a human urinary metabolite and a plant metabolite.
Vitamin B3 (Niacinamide) is a vitamin B3, a pyridinemonocarboxylic acid and a pyridine alkaloid.
Vitamin B3 (Niacinamide) is a conjugate acid of a nicotinate.
Vitamin B3 (Niacinamide) is a water-soluble B vitamin found naturally in some foods, added to foods, and sold as a supplement.
The two most common forms of Nicotinic acid in food and supplements are nicotinic acid and Vitamin B3 (Niacinamide).
The body can also convert tryptophan—an amino acid—to Vitamin B3 (Niacinamide).
Vitamin B3 (Niacinamide) also supports the functioning of the nervous system and contributes to the normal maintenance of skin and mucous membranes.
Vitamin B3 (Niacinamide) assists in the breakdown and utilisation of fats, proteins and carbohydrates.
Vitamin B3 (Niacinamide) also causes peripheral vascular dilation (which can lead to a temporary skin flushing after ingestion).
Vitamin B3 (Niacinamide) excess cholesterol is then excreted throughthe biliary tract.
Vitamin B3 (Niacinamide), also known as B3, is an important enzymatic component required for the body to function normally.
This vitamin allows us to obtain energy from macronutrients (carbohydrates and fats).
Vitamin B3 (Niacinamide), a very important micronutrient for energy synthesis, also contributes to the healthy functioning of the nervous and digestive systems.
In addition to these, Vitamin B3 (Niacinamide) is known that it is good for skin health and vitality, hair and eyes.
Vitamin B3 (Niacinamide), an enzymatic component, has an important role in the metabolism of fats and sugars.
In this way, cells have the ability to provide the energy they need to continue their normal functions.
Vitamin B3 (Niacinamide) also positively affects the vitality and health of the skin, eyes and hair and can be used for the treatment of skin conditions such as dermatitis, skin irritation and acne.
Vitamin B3 (Niacinamide)’s abilities are made possible thanks to its status as a multitasking bio-active ingredient.
However, this powerhouse form of vitamin B takes a bit of a journey before our skin and its supporting surface cells can reap its benefits.
After Vitamin B3 (Niacinamide)’s applied to skin, it’s broken down into the form of this vitamin that our cells can use, the coenzyme nicotinamide adenine dinucleotide.
Vitamin B3 (Niacinamide)’s this coenzyme that’s believed to be responsible for niacinamide’s benefits to skin.
Vitamin B3 (Niacinamide) may be used alongside other active ingredients for optimal results.
For example, some reports suggest that supplemental Vitamin B3 (Niacinamide) may work well alongside copper, folic acid, and zinc to treat acne.
You may be able to get more out of your Vitamin B3 (Niacinamide) serum by using it alongside hyaluronic acid.
Hyaluronic acid is said to increase product absorption.
Vitamin B3 (Niacinamide) has a plethora of benefits as a skin care ingredient including its ability to:
Minimize the appearance of enlarged pores and improve “orange peel” textured skin
Restore skin’s defenses against moisture loss and dehydration
Visibly even out skin tone and discolorations from sun damage
Among a handful of other amazing skin care ingredients such as retinol and vitamin C, Vitamin B3 (Niacinamide) is a standout because of its versatility for almost any skin care concern and skin type.
Uses of Vitamin B3 (Niacinamide):
For best results, use Vitamin B3 (Niacinamide) products that are meant to be left on skin (such as serums or moisturizers) instead of rinse-off products (like cleansers) where contact time is limited.
Vitamin B3 (Niacinamide) can be especially beneficial when applied after cleansing to rehydrate and replenish skin.
A concentrated 10% Vitamin B3 (Niacinamide) Booster can be used on its own (much like a serum) or mixed into your favorite non-SPF moisturizer, based on personal preference.
Those with stubborn concerns around advanced signs of sun damage, orange peel texture, lax pores, and oil-related bumps should consider trying an advanced strength 20% Vitamin B3 (Niacinamide) serum.
You can use Vitamin B3 (Niacinamide)-containing products around your eyes, too.
Some might find applying a moisturizer or Vitamin B3 (Niacinamide) eye cream helps soften the appearance of crow’s feet and dark circles, not to mention enables this delicate area to retain skin-smoothing moisture and resist loss of firmness.
Facial care products with Vitamin B3 (Niacinamide) can also be applied to the neck and chest.
For skin concerns beyond the face and neck, a Vitamin B3 (Niacinamide) body serum can be advantageous.
Vitamin B3 (Niacinamide)’s benefits on the body include tackling uneven tone, discolorations (including dotted marks around the hair follicles), plus restoring and strengthening skin’s moisture barrier.
Vitamin B3 (Niacinamide) Body Serum targets uneven tone and signs of aging on the body, making it a terrific addition to any post-shower body care routine.
People use Vitamin B3 (Niacinamide) to prevent vitamin B3 deficiency and related conditions such as pellagra.
Vitamin B3 (Niacinamide) is also used for acne, diabetes, cancer, osteoarthritis, aging skin, skin discoloration, and many other conditions, but there is no good scientific evidence to support most of these uses.
Vitamin B3 (Niacinamide) is a water-soluble vitamin that works with the natural substances in your skin to help visibly minimize enlarged pores, tighten lax or stretched out pores, improve uneven skin tone, soften fine lines and wrinkles, diminish dullness, and strengthen a weakened surface.
Vitamin B3 (Niacinamide) also reduces the impact of environmental damage because of its ability to improve skin’s barrier (its first line of defense), plus it also plays a role in helping skin to repair signs of past damage.
Left unchecked, this type of daily assault makes skin appear older, dull and less radiant.
Vitamin B3 is a water-soluble B vitamin that plays an important —in cleansers eye creams, serums, and sunscreens.
When used as part of your daily skincare regimen, Vitamin B3 (Niacinamide) may help calm your skin, reduce transepidermal water loss (TEWL), and increase moisture in your skin’s uppermost layer.
This makes Vitamin B3 (Niacinamide) a helpful skincare ingredient for those looking to promote hydrated, even-toned skin.
First studied for its skincare benefits in the 1970s, Vitamin B3 (Niacinamide) has since become a popular cosmetic ingredient in formulations for multiple skin types and skin concerns.
As a supplement, Vitamin B3 (Niacinamide) is used by mouth to prevent and treat pellagra (niacin deficiency).
While nicotinic acid (niacin) may be used for this purpose, Vitamin B3 (Niacinamide) has the benefit of not causing skin flushing.
As a cream, Vitamin B3 (Niacinamide) is used to treat acne, and has been observed in clinical studies to improve the appearance of aging skin by reducing hyperpigmentation and redness.
Vitamin B3 (Niacinamide) is a water-soluble vitamin.
Vitamin B3 (Niacinamide) is the supplement name while nicotinamide is the scientific name.
Acne, rosacea and sensitivity:
Vitamin B3 (Niacinamide)’s anti-inflammatory properties make it an attractive option for those who suffer from rosacea and sensitivity – both the type that you’re born with, as well as temporary post-product irritation that manifests as redness and stinging.
That said, oral and topical Vitamin B3 (Niacinamide) may have some actual benefits for skin health:
Skin cancer prevention:
Ask a dermatologist what Vitamin B3 (Niacinamide) does best, and the very first Vitamin B3 (Niacinamide) benefit they’ll list is probably “skin cancer prevention.”
In a 2015 study in the New England Journal of Medicine, researchers gave 386 patients 500 mg of oral Vitamin B3 (Niacinamide) or a placebo twice daily for a whole year.
All of the participants had at least two non-melanoma skin cancers within the previous five years and, therefore, were at a high risk for developing another skin cancer.
Results showed that during the study, there were 23% fewer new cases of skin cancer in the group that received Vitamin B3 (Niacinamide) (336 cancers) compared to those who got the placebo (463 cancers).
Skin cancer:
Vitamin B3 (Niacinamide) at doses of 500 to 1000 mg a day decreases the risk of skin cancers, other than melanoma, in those at high risk.
Vitamin B3 (Niacinamide) can be found in vitamin-rich foods, such as kale, mushrooms and almonds, which help take great care of your body from the inside, as well as in skin care products to pamper it from the outside.
People use Vitamin B3 (Niacinamide) to prevent vitamin B3 deficiency and related conditions such as pellagra.
Vitamin B3 (Niacinamide) is also used for acne, diabetes, cancer, osteoarthritis, aging skin, skin discoloration, and many other conditions, but there is no good scientific evidence to support most of these uses.
Vitamin B3 (Niacinamide) is a form of vitamin B3(niacin), a water-soluble vitamin; used in cosmetics and personal care products as a conditioning agent.
Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider.
No supplement is intended to treat, cure, or prevent disease.
Vitamin B3 (Niacinamide) is compatible with other powerful ingredients like peptides, hyaluronic acid, AHAs, BHA, and all types of antioxidants.
This multi-ingredient approach to skin care is important because as great as Vitamin B3 (Niacinamide) is, Vitamin B3 (Niacinamide)’s not the only ingredient skin needs to look and feel its best.
Think of Vitamin B3 (Niacinamide) like your diet—as healthy as kale is, if kale was all you ate, you’d soon become malnourished because your body needs more than one healthy food to maintain itself.
The same is true for skin, the body’s largest (and most exposed) organ.
Medical uses:
Niacin deficiency:
Vitamin B3 (Niacinamide) is the preferred treatment for pellagra, caused by niacin deficiency.
Acne:
Vitamin B3 (Niacinamide) cream is used as a treatment for acne.
Vitamin B3 (Niacinamide) has anti-inflammatory actions, which may benefit people with inflammatory skin conditions.
Vitamin B3 (Niacinamide) increases the biosynthesis of ceramides in human keratinocytes in vitro and improves the epidermal permeability barrier in vivo.
The application of 2% topical Vitamin B3 (Niacinamide) for 2 and 4 weeks has been found to be effective in lowering the sebum excretion rate.
Vitamin B3 (Niacinamide) has been shown to prevent Cutibacterium acnes-induced activation of toll-like receptor 2, which ultimately results in the down-regulation of pro-inflammatory interleukin-8 production.
Functions And Applications of Vitamin B3 (Niacinamide):
The proper digestion and absorption of protein and fat;
To help in the essential amion acid tryptophan is converted to nicotinic acid;
To prevent all kinds of nerves, skin diseases;
Alleviate vomiting;
Promote the nucleic acid Synthesis, to prevent the aging of tissues and organs;
Lower the result of taking antidepressants caused by dry mouth and dysuria
Slow night muscle spasms, cramps paralysis and other symptoms of hand,foot and neuritis;
Is the natural the diuretic.
Treatment of congenital hypofunction of metabolism.
Benefits of Vitamin B3 (Niacinamide):
Skin Benefits:
This multitalented ingredient is truly one that all can add to their routine, no matter skin type or skin concern.
Some people’s skin may have more concerns Vitamin B3 (Niacinamide) can address, but without question everyone’s skin will gain something from this B vitamin.
Minimizes enlarged pores:
Vitamin B3 (Niacinamide) is most famous for its ability to reduce the appearance of enlarged pores.
As we touched on above, research hasn’t determined how this B vitamin works its pore-reducing magic, but Vitamin B3 (Niacinamide) seems that Vitamin B3 (Niacinamide) has a normalizing ability on the pore lining.
This plays a role in helping to keep oil and debris from getting backed up, which leads to clogs and rough, bumpy skin.
As the clog forms and worsens, the pores stretch to compensate, leading to enlargement.
Routine usage of Vitamin B3 (Niacinamide) helps pores return to their natural size.
Sun damage can cause pores to become stretched, too, leading to what some describe as “orange peel skin”.
Higher concentrations of Vitamin B3 (Niacinamide) can help visibly tighten pores by shoring up skin’s supportive elements, often dramatically improving orange peel texture.
Added moisture:
Other benefits of Vitamin B3 (Niacinamide) are that it helps renew and restore skin’s surface against moisture loss and dehydration.
When key fatty acids in skin’s barrier known as ceramides gradually deplete, skin is left vulnerable to all sorts of problems, from persistent patches of dry, flaky skin to increasingly becoming extra-sensitive.
If you struggle with dry skin, topical application of Vitamin B3 (Niacinamide) has been shown to boost the hydrating ability of moisturizers so skin’s surface can better resist the moisture loss that leads to recurrent dryness and flaky texture.
Vitamin B3 (Niacinamide) works brilliantly with common moisturizer ingredients like glycerin, non-fragrant plant oils, cholesterol, sodium PCA, and sodium hyaluronate.
Brightens skin:
Both concerns stem from excess melanin (skin pigment) showing on skin’s surface.
In concentrations of 5% and greater, Vitamin B3 (Niacinamide) works via several pathways to keep new discolorations from appearing.
At the same time, Vitamin B3 (Niacinamide) also helps reduce the appearance of existing discolorations, so your skin tone looks more even.
Research has shown Vitamin B3 (Niacinamide) and tranexamic acid work particularly well together, and as mentioned above, Vitamin B3 (Niacinamide) can be used with other discoloration-reducing ingredients such as all forms of vitamin C, licorice, retinol, and bakuchiol.
For Skin Care:
Vitamin B3 (Niacinamide) has been studied for several different skin issues.
Acne treatment:
Researchers believe that Vitamin B3 (Niacinamide)’s anti-inflammatory effects can reduce the redness and inflammation caused by acne.
According to a review, topical (on the skin) Vitamin B3 (Niacinamide) reduced acne.
The review also found that oral (by mouth) Vitamin B3 (Niacinamide) and other supplements treated acne.
However, conclusions about using oral Vitamin B3 (Niacinamide) alone for acne cannot be made.
Aging skin:
According to a review, Vitamin B3 (Niacinamide) increased keratin, an essential protein for healthy skin, in cell cultures.
Vitamin B3 (Niacinamide) may also help with other aspects of skincare, such as wrinkles and other signs of aging skin, using topical (skin) products.
Melasma:
A skin condition that causes hyperpigmentation, or dark spots, melasma often occurs on unprotected skin regularly exposed to the sun.
According to a study, topical (skin) Vitamin B3 (Niacinamide) cream reduced the appearance of dark spots in people with melasma.
Skin cancer prevention:
In a randomized controlled trial, 12 months of treatment with 500 milligrams (mg) of Vitamin B3 (Niacinamide) by mouth twice daily reduced the risk of developing new non-melanoma skin cancers, new squamous-cell carcinomas (skin cancer), and actinic keratosis (i.e., pre-skin cancer).
More high-quality studies are needed before using Vitamin B3 (Niacinamide) for these conditions.
Always consult a healthcare provider specializing in skin health, such as a dermatologist, if you have developed a skin issue.
Self-treating with supplements or delaying diagnosis and treatment can make conditions worse.
Boost hydration:
Vitamin B3 (Niacinamide) may enhance the function of your skin’s lipid barrier (a layer of water and oil that protects your skin).
This helps lock moisture in and keep pollutants or other potential irritants out, making your skin more hydrated and less sensitive.
Calm redness:
Vitamin B3 (Niacinamide) has been shown to ease inflammation, which can help calm redness due to conditions like acne, rosacea and eczema.
Vitamin B3 (Niacinamide) can also soothe irritation caused by strong exfoliants like retinol or glycolic acid that remove dead cells from the surface of your skin.
May reduce the appearance of pores:
Nothing has been proven to reduce the actual size of your pores.
But Vitamin B3 (Niacinamide) may help minimize their appearance by helping keep your skin smooth and clear.
Vitamin B3 (Niacinamide) also may help regulate the amount of oil your glands produce, which can prevent breakouts and clogged pores.
Possibly protect against skin cancer:
Vitamin B3 (Niacinamide) is a close relative of another B vitamin called nicotinamide.
Oral Vitamin B3 (Niacinamide) supplements may help prevent new skin cancer or precancerous spots from developing in some people.
But more studies are needed to confirm this benefit.
A recent study also shows nicotinamide, the cousin of Vitamin B3 (Niacinamide), may increase the risk of triple-negative breast cancer in those who take the dietary supplement in high levels.
But using Vitamin B3 (Niacinamide) in a skin care product and applying it topically is generally regarded as safe.
Treat dark spots:
Vitamin B3 (Niacinamide) is dermatologist-approved for brightening skin tone.
Some research suggests skin care formulas with 5% Vitamin B3 (Niacinamide) can also help lighten dark spots.
In one small study, a combination of skin brighteners including retinol and Vitamin B3 (Niacinamide) reduced dark spots and fine lines.
They also improved skin radiance and texture.
Reduce wrinkles and fine lines:
This vitamin’s antioxidant properties may help protect your skin and aid Vitamin B3 (Niacinamide)’s recovery from damage due to factors like aging, sun and stress.
Some research has shown topical Vitamin B3 (Niacinamide) can improve fine lines and wrinkles, as well as skin sallowness.
Individual Benefits of Vitamin B3 (Niacinamide):
Immunity.
Vitamin B3 (Niacinamide) helps build keratin, a type of protein that keeps your skin firm and healthy.
Lipid barrier:
Vitamin B3 (Niacinamide) can help your skin grow a ceramide (lipid) barrier, which can, in turn, helps retain moisture.
This is beneficial for all skin types, especially if you have eczema or mature skin.
Minimizes redness and blotchiness:
Vitamin B3 (Niacinamide) reduces inflammation, which may help ease redness from eczema, acne, and other inflammatory skin conditions.
Minimizes pore appearance:
Keeping skin smooth and moisturized may have a secondary benefit — a natural reduction in pore size over time.
Regulates oil:
The benefits of moisture retention aren’t just for those with dry skin types.
Niacinimide can also help regulate the amount of oil the sebaceous glands produce and prevent your glands from going into overdrive.
Vitamin B3 (Niacinamide) protects against sun damage.
Vitamin B3 (Niacinamide) can concurrently rebuild healthy skin cells while also protecting them from damage caused by ultraviolet rays.
Treats hyperpigmentation:
Some research has found that 5 percent Vitamin B3 (Niacinamide) concentrations can be helpful in lightening dark spots.
Benefits were seen after four weeks, but not beyond two months.
This benefit may be due to increased collagen production.
Minimizes fine lines and wrinkles:
Research has also found that the same concentration was helpful in reducing some signs of sun damage that come with aging.
This includes fine lines and wrinkles.
Protects against oxidative stress.
Vitamin B3 (Niacinamide) helps build cells in the skin while also protecting them from environmental stresses, such as sunlight, pollution, and toxins.
Treats acne:
Vitamin B3 (Niacinamide) may be helpful for severe acne, especially inflammatory forms like papules and pustules.
Over time, you may see fewer lesions and improved skin texture.
Industrial Production of Vitamin B3 (Niacinamide):
The hydrolysis of nicotinonitrile is catalysed by the enzyme nitrile hydratase from Rhodococcus rhodochrous J1, producing 3500 tons per annum of Vitamin B3 (Niacinamide) for use in animal feed.
The enzyme allows for a more selective synthesis as further hydrolysis of the amide to nicotinic acid is avoided.
Vitamin B3 (Niacinamide) can also be made from nicotinic acid.
According to Ullmann’s Encyclopedia of Industrial Chemistry, worldwide 31,000 tons of nicotinamide were sold in 2014
Chemistry of Vitamin B3 (Niacinamide):
The structure of Vitamin B3 (Niacinamide) consists of a pyridine ring to which a primary amide group is attached in the meta position.
Vitamin B3 (Niacinamide) is an amide of nicotinic acid.
As an aromatic compound, Vitamin B3 (Niacinamide) undergoes electrophilic substitution reactions and transformations of its two functional groups.
Examples of these reactions reported in Organic Syntheses include the preparation of 2-chloronicotinonitrile by a two-step process via the N-oxide, from nicotinonitrile by reaction with phosphorus pentoxide, and from 3-aminopyridine by reaction with a solution of sodium hypobromite, prepared in situ from bromine and sodium hydroxide.
Biochemistry:
Vitamin B3 (Niacinamide), as a part of the cofactor Vitamin B3 (Niacinamide) adenine dinucleotide (NADH / NAD+) is crucial to life.
In cells, Vitamin B3 (Niacinamide) is incorporated into NAD+ and Vitamin B3 (Niacinamide) adenine dinucleotide phosphate (NADP+).
NAD+ and NADP+ are cofactors in a wide variety of enzymatic oxidation-reduction reactions, most notably glycolysis, the citric acid cycle, and the electron transport chain.
If humans ingest Vitamin B3 (Niacinamide), it will likely undergo a series of reactions that transform it into NAD, which can then undergo a transformation to form NADP+.
This method of creation of NAD+ is called a salvage pathway.
However, the human body can produce NAD+ from the amino acid tryptophan and niacin without our ingestion of Vitamin B3 (Niacinamide).
NAD+ acts as an electron carrier that mediates the interconversion of energy between nutrients and the cell’s energy currency, adenosine triphosphate (ATP).
In oxidation-reduction reactions, the active part of the cofactor is the Vitamin B3 (Niacinamide).
In NAD+, the nitrogen in the aromatic Vitamin B3 (Niacinamide) ring is covalently bonded to adenine dinucleotide.
The formal charge on the nitrogen is stabilized by the shared electrons of the other carbon atoms in the aromatic ring.
When a hydride atom is added onto NAD+ to form NADH, the molecule loses Vitamin B3 (Niacinamide)’s aromaticity, and therefore a good amount of stability.
This higher energy product later releases Vitamin B3 (Niacinamide)’s energy with the release of a hydride, and in the case of the electron transport chain, Vitamin B3 (Niacinamide) assists in forming adenosine triphosphate.
When one mole of NADH is oxidized, 158.2 kJ of energy will be released.
Biological Role of Vitamin B3 (Niacinamide):
Vitamin B3 (Niacinamide) occurs as a component of a variety of biological systems, including within the vitamin B family and specifically the vitamin B3 complex.
Vitamin B3 (Niacinamide) is also a critically important part of the structures of NADH and NAD+, where the N-substituted aromatic ring in the oxidised NAD+ form undergoes reduction with hydride attack to form NADH.
The NADPH/NADP+ structures have the same ring, and are involved in similar biochemical reactions.
Vitamin B3 (Niacinamide) can be methylated in the liver to biologically active 1-Methylnicotinamide when there’s sufficient methyl donors.
Food Sources of Vitamin B3 (Niacinamide):
Vitamin B3 (Niacinamide) occurs in trace amounts mainly in meat, fish, nuts, and mushrooms, as well as to a lesser extent in some vegetables.
Vitamin B3 (Niacinamide) is commonly added to cereals and other foods.
Many multivitamins contain 20–30 mg of vitamin B3 and Vitamin B3 (Niacinamide) is also available in higher doses.
Research of Vitamin B3 (Niacinamide):
A 2015 trial found Vitamin B3 (Niacinamide) to reduce the rate of new nonmelanoma skin cancers and actinic keratoses in a group of people at high risk for the conditions.
Vitamin B3 (Niacinamide) has been investigated for many additional disorders, including treatment of bullous pemphigoid nonmelanoma skin cancers.
Vitamin B3 (Niacinamide) may be beneficial in treating psoriasis.
There is tentative evidence for a potential role of Vitamin B3 (Niacinamide) in treating acne, rosacea, autoimmune blistering disorders, ageing skin, and atopic dermatitis.
Vitamin B3 (Niacinamide) also inhibits poly(ADP-ribose) polymerases (PARP-1), enzymes involved in the rejoining of DNA strand breaks induced by radiation or chemotherapy.
ARCON (accelerated radiotherapy plus carbogen inhalation and Vitamin B3 (Niacinamide)) has been studied in cancer.
Research has suggested Vitamin B3 (Niacinamide) may play a role in the treatment of HIV.
Handling and Storage of Vitamin B3 (Niacinamide):
Handling:
Personal Protection:
Wear appropriate protective equipment, including gloves and safety goggles, to prevent skin and eye contact.
Ventilation: Ensure adequate ventilation in the work area to avoid inhalation of dust or vapors.
Hygiene:
Wash hands thoroughly after handling the material and avoid eating, drinking, or smoking in the work area.
Storage:
Conditions:
Store in a cool, dry place, away from direct sunlight and moisture.
Vitamin B3 (Niacinamide) should be kept in a tightly sealed container.
Compatibility:
Keep away from strong acids, strong bases, and oxidizing agents.
Temperature:
Store at room temperature, typically between 15-25°C (59-77°F), unless otherwise specified by the manufacturer.
Reactivity and Stability of Vitamin B3 (Niacinamide):
Reactivity:
Incompatibilities:
Vitamin B3 (Niacinamide) is generally stable but can react with strong acids, strong bases, and oxidizing agents.
Avoid contact with these substances.
Conditions to Avoid:
High temperatures and direct sunlight may cause degradation.
Stability:
Chemical Stability:
Vitamin B3 (Niacinamide) is stable under normal conditions of use and storage.
Decomposition Products:
Decomposition products may include carbon oxides and nitrogen oxides if exposed to extreme conditions, though such occurrences are rare.
First Aid Measures of Vitamin B3 (Niacinamide):
Inhalation:
Move the affected person to fresh air immediately.
Seek medical attention if symptoms persist.
Skin Contact:
Wash the affected area with plenty of water and soap.
Remove contaminated clothing.
Seek medical advice if irritation occurs.
Eye Contact:
Rinse the eyes with plenty of water for at least 15 minutes, lifting the upper and lower eyelids occasionally.
Get medical attention if irritation persists.
Ingestion:
Rinse the mouth with water.
If the person is conscious and alert, give them water to drink.
Seek medical attention immediately.
Fire Fighting Measures of Vitamin B3 (Niacinamide):
Fire Extinguishing Agents:
Use water spray, foam, dry chemical, or carbon dioxide (CO2) to extinguish fires.
Fire Fighting Procedures:
Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and inhalation of fumes.
Cool containers exposed to fire with water to prevent rupture.
Hazardous Combustion Products:
In case of fire, hazardous decomposition products may include carbon oxides and nitrogen oxides.
Accidental Release Measures of Vitamin B3 (Niacinamide):
Personal Precautions:
Wear appropriate personal protective equipment, including gloves and safety goggles.
Avoid dust formation and inhalation of dust.
Environmental Precautions:
Prevent the material from entering waterways or sewers.
If spillage occurs, contain Vitamin B3 (Niacinamide) to avoid contamination.
Cleanup Procedures:
Sweep up and place the material in a suitable, clearly labeled container for disposal.
Clean the area with water and detergent if needed.
Exposure Controls/Personal Protection of Vitamin B3 (Niacinamide):
Exposure Limits:
Vitamin B3 (Niacinamide) does not have specific occupational exposure limits, but general good practices should be followed to minimize exposure.
Engineering Controls:
Ensure adequate ventilation in the working area to avoid accumulation of dust or vapors.
Personal Protective Equipment (PPE):
Respiratory Protection:
Use a dust mask if dust is generated.
Gloves:
Wear chemical-resistant gloves to prevent skin contact.
Eye Protection:
Use safety goggles or glasses to protect the eyes from dust or splashes.
Clothing:
Wear suitable protective clothing to prevent skin contact.
Identifiers of Vitamin B3 (Niacinamide):
CAS Number: 59-67-6
Molecular Formula: C6H5NO2
Molecular Weight: 123.11
EINECS Number: 200-441-0
Common Name: Vitamin B3 (Niacinamide)
IUPAC Name: 3-Pyridinecarboxamide
Molecular Formula: C₆H₈N₂O
CAS Registry Number: 98-92-0
EINECS Number: 202-713-4
Beilstein Number: 611046
RTECS Number: VZ7700000
CAS Number: 98-92-0
Molecular Weight: 122.12
Beilstein: 383619
EC Number: 202-713-4
MDL number: MFCD00006395
Cas No.: 59-67-6
Ec No.: 200-441-0
Beilstein No.:109591
Empirical Formula (Hill Notation): C6H5NO2
Molecular Weight: 123.11
Properties of Vitamin B3 (Niacinamide):
Physical state: crystalline
Color: white
Odor: odorless
Melting point/freezing point:
Melting point/range: 128 – 131 °C – lit.
Initial boiling point and boiling range: 150 – 160 °C at 0,0007 hPa
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 150 °C – closed cup
Autoignition temperature: not auto-flammable
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: 500 g/l at 25 °C
Partition coefficient: n-octanol/water:
log Pow: -0,38 at 21 °C – Bioaccumulation is not expected.
Vapor pressure: No data available
Density: 1,40 g/cm3 at 25 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Melting point: 128-131 °C(lit.)
Boiling point: 150-160 °C
Density: 1.40
vapor density: 4.22 (vs air)
vapor pressure: 0Pa at 25℃
refractive index: 1.4660 (estimate)
Flash point: 182 °C
storage temp.: 2-8°C
solubility: 691g/l
pka: 3.3(at 20℃)
form: powder
color: white
PH: 6.0-7.5 (50g/l, H2O, 20℃)
Odor: Odorless
PH Range: 9
Water Solubility: 1000 g/L (20 ºC)
Decomposition: >=200 °C
Merck: 14,6523
BRN: 383619
BCS Class: 1
LogP: -0.38 at 21℃
Specifications of Vitamin B3 (Niacinamide):
Form: White to slightly yellowish crystalline powder.
Assay: Typically ≥ 98% by HPLC.
Melting Point: 128-130°C (262-266°F)
Solubility: Soluble in water, ethanol, and acetone.
1% Solution: pH 6.0-7.0
UV Absorption: Characteristic absorbance around 263 nm.
IR Spectrum: Should match the reference for Vitamin B3 (Niacinamide).
Heavy Metals:
Limit: ≤ 10 ppm.
Microbial Limits
Total Plate Count: ≤ 1000 cfu/g.
Yeast and Molds: ≤ 100 cfu/g.
Pathogens: Should be free from pathogens like E. coli and Salmonella.