ZINC (OMADINE) PRYTHIONE ( NKO OMADN PRZYON)
ZINC PRYTIONE (ÇNKO PRTON)
CAS NO: 13463-41-7
METATAGS;2-pyridinethiol, 1-oxide, zinc salt;Zinc pyrithione;1-Hydroxypyridine-2-thione zinc salt; Zinc Pyrithione; Pyrithione zinc; 2-Pyridinethiol 1-Oxide Zinc Salt; Bis(2-pyridylthio) Zinc 1,1′-Dioxide; Mercaptopyridine N-oxide zinc salt; 2-Mercaptopyridine N-oxide zinc salt;109702-19-4, 118480-78-7, 1192-70-7, 1320-68-9, 13463-41-7, 14376-32-0, 15686-64-3, 162400-43-3, 16782-00-6, 17652-47-0, 192458-89-2, 208398-70-3, 2(1H)-Pyridinethione, 1-hydroxy-, zinc complex, 226883-65-4, 244778-79-8, 2C5H4NOS.Zn, 2-Mercaptopyridine 1-oxide zinc salt, 2-Pyridinethiol-1-oxide, zinc salt, 31089-48-2, 3138-01-0, 35430-20-7, 3590-23-6, 39412-61-8, 51148-10-8, 51406-57-6, 55172-61-7, 74261-71-5, AI3-62421, BC-J, Biocut ZP, Bis(1-hydroxy-2(1H)-pyridinethionato)zinc, Bis(2-pyridinethiol-1-oxide)zinc, Bis(2-pyridylthio)zinc 1,1′-dioxide, bis(N-oxopyridine-2-thionato)zinc (II), Breck One Dandruff Shampoo, C10H8N2O2S2Zn, Caswell No. 923, CCRIS 4894, EINECS 236-671-3, EPA Pesticide Chemical Code 088002, Evafine P 50, Finecide ZPT, FSB 8332, Head and Shoulders, HEAD AND SHOULDERS CONDITIONER, HEAD & SHOULDERS CONDITIONER, Hokucide ZPT, HSDB 4498, LS-784, NCGC00091933-01, Niccanon SKT, NSC 290409, OM-1563, Omadine Zinc, Piritionato cincico [INN-Spanish], PYRITHIONE ZINC, Pyrithione zinc derivative, Pyrithione zincique [INN-French], Pyrithione zinc [USAN:BAN:INN], Pyrithione zinc [USAN:INN:BAN], Pyrithionum zincicum [INN-Latin], Sebulon Shampoo, (T-4)-bis(1-hydroxy-2(1H)- pyridinethionato-O,S)zinc, (T-4)-Bis(1-hydroxy-2(1H)-pyridinethionato-O,S)zinc, Tomicide Z 50, Tomicide ZPT 50, Top Brass, Vancide P, Vancide ZP, Wella Crisan, Zinc 1-hydroxy-2-pyridinethione, zinc 1-oxidanidylpyridin-1-ium-2-thiolate, zinc 1-oxidopyridin-1-ium-2-thiolate, Zinc 2-mercaptopyridine N-oxide, Zinc 2-pyridinethiol-1-oxide, Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)-, Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)- (8CI), Zinc, bis(1-hydroxy-2(1H)-pyridinethionato-O,S)-(T-4)-, Zinc, bis(1-(hydroxy-kappaO)-2(1H)-pyridinethionato-kappaS2)-, (T-4)-, Zinc, bis[1-(hydroxy-.kappa.O)-2(1H)-pyridinethionato-.kappa.S2]-, (T-4)-, Zinc, bis(2-pyridinylthio)-, N,N’-dioxide, Zinc, bis(2-pyridylthio)-, 1,1′-dioxide, Zinc, bis(2-pyridylthio)-, N,N’-dioxide, Zinc bis(2-pyridylthio)-N-oxide, zinc bis(2-thioxopyridin-1(2H)-olate), Zinci pyrithionum, Zinc Omadine, Zincon Dandruff Shampoo, Zincpolyanemine, Zinc pt, Zinc pyrethion, Zinc pyridine-2-thiol 1-oxide, Zinc pyridine-2-thiol-1-oxide, Zinc pyridinethione, Zinc – pyrion, Zinc pyrithione, ZNP bar, ZnPT, Zn – pyrion, ZPT;biocut ZP;breck one dandruff shampoo;chemical ZPT;head and shoulders;2-mercaptopyridine N-oxide zinc salt;2-mercaptopyridine-1-oxide zinc salt;bis[pyridine-2-thiolato-kappaS 1(oxide-kappaO)]zinc;bis(2-pyridinethiol-1-oxide)zinc;2-pyridinethiol, 1-oxide, zinc salt (2:1);bis(2-pyridylthio)zinc 1,1′-dioxide;pyrithione zinc;pyrithionum zincicum;sebulon shampoo;tomicide ZPT 50;vancide ZP;zinc bis(pyridine-2-thiolate 1-oxide);zinc omadine enhanced CP dispersion;zinc omadine fine particle size (FPS) fungicide-algaecide dispersion (zinc pyrithione);zinc omadine general fungicide-algaecide dispersion (zinc pyrithione);zinc pyrithione 48-50 dispersion (cleanbio zinc);zinc, bis(1-(hydroxy-kappaO)-2(1H)-pyridinethionato-kappaS2)-, (T-4)-;zinc, bis(1-hydroxy-2(1H)-pyridinethionato-O,S)-(T-4)-;zinc, bis(1-hydroxy-2(1H)-pyridinethionato)- (8CI);zinc, bis(2-pyridinylthio)-, N,N’-dioxide;zinc, bis(2-pyridylthio)-, 1,1′-dioxide;zinc, bis(2-pyridylthio)-, N,N’-dioxide;zinc;1-oxidopyridin-1-ium-2-thiolate;zincon dandruff shampoo;zincpolyanemine;ZPT;ZNPT;zincpt;OM-1563;vancidep;de-squaman;vancide zp;zincpyrion;ZPT(power);ZINC PYRIT;zink priorin;znk prorn;ZINK PRIORIN;ZNK PRORN;zinc priorin;znc prorn;ZINC PRIORIN;ZNK PRORN;AMPUAN;KEPEKAMPUANI;SHAMPOO;çinko priorin;çnko priorin;ÇNKO PRORN;ÇINKO PRIORIN;CINKO PRIORIN;CNKO PRORN;cnkoprorn;cinkopriorin;zincpriorin;zncprorn;ZNCPRORN;ZINCPRIORIN;ZNKPRORN;ZINKPRIORIN;zinkpriorin;znkprorn;ÇNKOPRORN;CNKOPRORN;ÇINKOPRIORIN;CINKOPRIORIN;ÇINKIPRIORIN
Molecular weight of Zinc Prytione
317.70
Molecular formula of Zinc Prytione
C10H8N2O2S2Zn
Appearance of Zinc Prytione
beige fine granules (est)
Melting Point of Zinc Prytione
240.00 °C. @ 760.00 mm Hg
Boiling Point of Zinc Prytione
350.20 °C. @ 760.00 mm Hg
Vapor Pressure of Zinc Prytione
0.000091 mm/Hg @ 25.00 °C.
Flash Point of Zinc Prytione
330.00 °F. TCC ( 165.60 °C. )
logP (o/w) of Zinc Prytione
-0.900
Product description of Zinc Prytione
Also known as zinc Omadine ,this pyrithione complexes of zinc bromide, in the early 1930s, was already synthesized and used as a topical antifungal or antibacterial agent. At room temperature it is white to yellow crystalline powder. Slight characteristic odor. Insoluble in water. Solubility: water 15mg/kg; pH = 8 Water 35mg/kg; Ethanol 100mg/kg; polyethylene glycol (PEG400) 2000mg/kg. A pH optimum range of 4.5 to 9.5; mass fraction of 10% suspension pH3.6. Zinc pyrithione react with cationic and non-ionic surfactants forming insoluble precipitate, unstable in the light and oxidizer, when at higher temperatures ,it is not stable to acids and bases . It is not compatible with EDTA, non-ionic surfactants make it partially deactivated. When with the presence of heavy metals, chelation or anti-sequestration will occur, and these chelates are insoluble in water.
EEC and GB7916-87 provide that maximum allowable concentration of mass fraction of zinc pyrithione on cosmetics is 0.5%, only for cleaning after using products.General concentration 250~1000mg/kg (active), zinc pyrithione can be used in gels, creams, lotions, talcum powder and anti-dandruff shampoo, deodorant and also for disinfecting articles.Zinc is a formulated form, most commonly used in intensive dandruff treatment alone, but it is known to be effective with climbazole in cases where excessive dandruff, oily eczema and psoriasis are very exaggerated.
This effect is called keratolytic effect by dissolving the dead skin layer which develops due to the rapid skin regeneration caused by Zinc pyrition. It is also called keratolytic effect. In case of seborrheic dermatitis te is the main problem for excessive dandruff, additional use of climbazole will increase the success in treatment.
Zinc Pyrithione is an antimicrobial added to shampoos to treat dandruff and seborrhoeic dermatitis. The molecule is a pyrithione complex of zinc, and so is also commonly (but confusingly) referred to as ‘pyrithione zinc’. Shampoos containing zinc pyrithione can be typically be bought without a prescription.
In Europe, zinc pyrithione is regulated as a preservative and not a medication. This means that the ingredient is subject to different regulations to other active ingredients found in shampoos (e.g. ketoconazole) – and importantly, the manufacturer decides the dosing schedule. The shampoos are typically left for 5-10 minutes before rinsing, and applied every 2 to 3 days. This can vary by brand, and depends on any other ingredients in the shampoo.
Zinc Pyrithione occurs as white to slightly yellow crystals. In cosmetics and personal care products, Zinc Pyrithione is used in the formulation of cleansing products, hair conditioners, shampoos, eyeliners, face powders and skin care products.
Uses of Zinc Pyrithione
Shampoo for dandruff,zinc pyrithione can inhibit Gram positive and negative bacteria and mold growth,Care hair Effectively , delay hair aging ,control white hair and hair loss generation. zinc pyrithion is also used as a cosmetic preservative, oil, paint biocide.
Zinc pyrithione has a strong killing power on fungi and bacteria so that it can effectively kill dandruff fungus,playing a role in dandruff .
Chemical Properties of Zinc Pyrithione
Beige granules
antibacterial (urinary)
General Description
Fine beige granules.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Organometallics, such as Zinc pyrithione, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases.
Çinko Prytiyonun moleküler arl
317,70
Çinko Prytiyonun moleküler formülü
C10H8N2O2S2Zn
Çinko Prytiyonun Görünüü
Bej ince granüller (est)
Çinko Prytione Erime Noktas
240.00 ° C. @ 760.00 mm Hg
Çinko Prytionun Kaynama Noktas
350.20 ° C. @ 760.00 mm Hg
Çinko Prytiyonun Buhar Basnc
0.000091 mm / Hg @ 25.00 ° C.
Çinko Prytione’nin Parlama Noktas
330.00 ° F TCC (165.60 ° C.)
LogP (o / w) Çinko Prytione
-0,900
Ürün Açklamas
Çinko Omadin olarak da bilinir, 1930’larn banda çinko bromid’in piritiyon kompleksleri zaten sentezlenmi ve topikal bir antifungal veya antibakteriyel madde olarak kullanlmtr. Oda scaklnda beyaz ila sar kristal tozdur. Hafif karakteristik koku. Suda çözünmez. Çözünürlük: su 15mg / kg; PH = 8 Su 35mg / kg; Etanol 100mg / kg; Polietilen glikol (PEG400) 2000 mg / kg. 4.5 ila 9.5 arasnda bir pH optimum aral; % 10 süspansiyon pH3.6 kütle fraksiyonu. Çinko pirition, çözünmeyen çökelti oluturan katyonik ve iyonik olmayan yüzey aktif cisimlerle reaksiyona girer, kta ve oksidansta dengesiz, yüksek scaklklarda asitler ve bazlar için kararl deildir. EDTA ile uyumlu deildir, iyonik olmayan yüzey aktif maddeler ksmen deaktive edilir. Ar metallerin bulunmas durumunda elasyon veya anti-sekestrasyon meydana gelir ve bu çelat suda çözünmez.Çinkonun bir tür formülize edilmi halidir, youn kepek tedavisinde en yaygn kullanlan maddedir,tek bana yeterli olabilmektedir ancak ar kepek, yal egzama ve sedef hastal gibi kepein çok abartl olduu durumlarda climbazol ile etkinliinin çok artt bilinmektedir.
Zink pyrition kepein sebebi olan hzl cilt yenilenmesine bal olarak gelien ölü cilt tabakasn eriterek sorunu çözer bu etkisine keratolitik etki denir.Gerek seboreik dermatit te gerekse ar kepeklenmede asl sorun mantar olduu için ek olarak climbazole kullanlmas tedavide baary artracaktr.
EEC ve GB7916-87, kozmetik ürünlerinde çinko piritiyon kütle fraksiyonunun maksimum izin verilen konsantrasyonunun% 0,5 olduunu, yalnzca ürünlerin kullanmdan sonra temizlenmesini salar. Genel konsantrasyon 250 ~ 1000mg / kg (aktif), çinko pirition, jel, krem, Losyonlar, talk pudras ve kepek öncesi ampuan, deodorant ve ayrca eyalarn dezenfekte edilmesi için.
Çinko Pyrithione, kepek ve seboreik dermatiti tedavi etmek için ampuanlara eklenen bir antimikrobik maddedir. Molekül, çinko piritiyon kompleksidir ve bu nedenle de yaygn olarak (ancak kark olarak) ‘piritiyon çinko’ olarak anlr. Çinko piritiyon içeren ampuanlar tipik olarak reçetesiz satn alnabilir.
Avrupa’da, çinko piritiyon bir ilaç olarak deil bir koruyucu olarak düzenlenir. Bu, bileenin ampuanlarda bulunan dier aktif maddelere (örn., Ketokonazol) farkl düzenlemelere tabi olduu anlamna gelir; ve önemlisi, üretici doz emasna karar verir. ampuanlar genellikle durulamadan önce 5-10 dakika bekletilir ve her 2-3 günde bir uygulanr. Bu markaya göre deiiklik gösterebilir ve ampuan içindeki dier bileenlere baldr.
Çinko Piridin, beyaz ila hafif sar kristaller halinde bulunur. Kozmetik ve kiisel bakm ürünlerinde Zinc Pyrithione, temizlik ürünleri, saç kremi, ampuan, göz kapaklar, yüz tozlar ve cilt bakm ürünlerinde kullanlr.
Çinko Piridin’in Kullanm Alanlar
Kepek için ampuan, çinko piritiyon Gram pozitif ve negatif bakterileri ve kalp büyümesini inhibe edebilir, Saçlar etkili bir ekilde bakma sokar, saç yalanmay geciktirir, beyaz saçlar kontrol altna alr ve saç dökülmesini önler. Çinko pirition ayn zamanda bir kozmetik koruyucu, ya, boya biyosit olarak da kullanlr.
Çinko piritiyon mantarlar ve bakterileri güçlü bir öldürme gücüne sahiptir, böylelikle kepekli mantarlar etkili bir ekilde öldürerek kepekli bir rol oynamaktadr.
Çinko Piridin’in Kimyasal Özellikleri
Bej granülleri
Antibakteriyel (üriner)
Genel açklama
nce bej zerreleri.
Hava ve Su Reaksiyonlar
Suda çözünmez.
Reaktivite Profili
Çinko pirition gibi organometalikler birçok dier grupla reaktiftir. Asitler ve bazlarla uyumaz. Organometalikler iyi indirgeyici ajanlardr ve bu nedenle oksitleyici ajanlarla uyumazlar. Toksik veya yanc gazlar üretmek için genellikle su ile reaktiftir.