SODIUM BOROHYDRIDE (SODYUM BORHDRR) ;
SODIUM BOROHYDRIDE ;
EC Number; 241-004-4
CAS Number;16940-66-2
Synonym: Sodium tetrahydridoborate, Vertellus; Sodium borohydride; ODGROJYWQXFQOZ-UHFFFAOYSA-N; Sodium tetrahydroborate; Sodium borohydrate; Borol;N Sodium hydroborate; Hidkitex DF; Sodium, boryl- (9CI); Borate(1-), tetrahydro-, sodium; Sodium tetrahydroborate(1-); UNII-87L0B9CPPA; sodium boron(1-); Sodium tetrahydridoborate(1-); Borohydrure de sodium [French]; CCRIS 8892; HSDB 699; Sodium borohydride (Na(BH4)); EINECS 241-004-4; UN1426; 137141-62-9; MFCD00003518; sodium borotritide; borylsodium; Sodium boro hydrate; ACMC-20mwgn; Sodium,boryl-(9ci); BH4Na; VenPure(R) SF, powder; Sodium borohydride, caplets; 87L0B9CPPA; Sodium borohydride, >=95%; Sodium borohydride, 98.0%; sodium tetrahydroborate (1-); Jsp003441; SODIUM BORODEUTERIDE- D4; CTK0H4619; MolPort-001-788-012; ODGROJYWQXFQOZ-UHFFFAOYSA-N; Sodium borohydride, powder, 98%; ACT09094; KS-00000WD7; AKOS015832967; AKOS015913931; Sodium borohydride, granular, >=98%; OR28836; RTR-035893; Sodium borohydride, powder, >=98.0%; 29158-40-5; AN-15590; IN010199; LS-45014; Sodium borohydride, ReagentPlus(R), 99%TR-035893; FT-0689136; S0480; Sodium borohydride solution, 3 M in tetraglyme; Sodium borohydride, hydrogen-storage grade, 98%; Sodium borohydride, pellets, diam. 11 mm, 98%; Sodium borohydride, SAJ first grade, >=95.0%; A811099; Sodium borohydride, granular, 10-40 mesh, 98%; Sodium borohydride [UN1426] [Dangerous when wet]; Sodium borohydride [UN1426] [Dangerous when wet]; I14-16064; I14-43078; Sodium borohydride, caplets (18 x 10 x 8 mm), 98%; Sodium borohydride, granular, 99.99% trace metals basis; Sodium borohydride solution, 0.5 M in 2-methoxyethyl ether; Sodium borohydride, purum p.a., >=96% (gas-volumetric); Sodium borohydride solution, SWS, ~12 wt. % in 14 M NaOH; Sodium borohydride, purum, >=97.0% (gas-volumetric), tablet; Sodium borohydride, stable aqueous solution, 4.4M in 14M NaOH; Sodium borohydride solution, 2.0 M in triethylene glycol dimethyl ether; Sodium borohydride, 90% NaBH4 basis, pellets, diam. 8 mm, Cobalt (Doped); 1303-74-8; 13034-02-1; 24917-15-5; Sodium borohydride on aluminum oxide, extent of labeling: ~10 wt. % loading, matrix basic ; Sodium tetrahydridoborate; AF;SBH;Rpn10;NaBH4;BH4Na;borol;VenPure;hidkitexdf;VenPure(R);VenPure? AF; Borate(1-), tetrahydro-, sodium (1:1) [ACD/Index Name]; borohydrure de sodium [French]; NaBH4 [Formula]; Natriumtetrahydroborat [German] [ACD/IUPAC Name]; Sodium borohydride [Wiki]; Sodium tetrahydroborate [ACD/IUPAC Name]; Ttrahydroborate de sodium [French] [ACD/IUPAC Name]; 硼氢化钠 [Chinese]; 16940-66-2 [RN]; 241-004-4 [EINECS]; [16940-66-2]137141-62-9 [RN]; 15681-89-7 [RN]; borohydrure de sodium; MFCD00003518; sodium boron(-1) tetrahydride anion; SODIUM TETRAHYDRIDOBORATE; sodium tetrahydridoborate(1-); sodium tetrahydroborate(1-); Sodium, boryl- (9CI); Sodiumborohydride; UNII:87L0B9CPPA; UNII-87L0B9CPPA ; Sodium Tetrahydridoborate; Sodium Tetrahydroborate; Sodium tetrahydridoborate; Sodium tetrahydroborate; MFCD00003518; SBH, Sodium tetrahydroborate; Sodium tetrahydridoborate, Vertellus; Sodium borohydride; ODGROJYWQXFQOZ-UHFFFAOYSA-N; Sodium tetrahydroborate; Sodium borohydrate; Borol;N Sodium hydroborate; Hidkitex DF; Sodium, boryl- (9CI); Borate(1-), tetrahydro-, sodium; Sodium tetrahydroborate(1-); UNII-87L0B9CPPA; sodium boron(1-); Sodium tetrahydridoborate(1-); Borohydrure de sodium [French]; CCRIS 8892; HSDB 699; Sodium borohydride (Na(BH4)); EINECS 241-004-4; UN1426; 137141-62-9; MFCD00003518; sodium borotritide; borylsodium; Sodium boro hydrate; ACMC-20mwgn; Sodium,boryl-(9ci); BH4Na; VenPure(R) SF, powder; Sodium borohydride, caplets; 87L0B9CPPA; Sodium borohydride, >=95%; Sodium borohydride, 98.0%; sodium tetrahydroborate (1-); Jsp003441; SODIUM BORODEUTERIDE- D4; CTK0H4619; MolPort-001-788-012; ODGROJYWQXFQOZ-UHFFFAOYSA-N; Sodium borohydride, powder, 98%; ACT09094; KS-00000WD7; AKOS015832967; AKOS015913931; Sodium borohydride, granular, >=98%; OR28836; RTR-035893; Sodium borohydride, powder, >=98.0%; 29158-40-5; AN-15590; IN010199; LS-45014; Sodium borohydride, ReagentPlus(R), 99%; TR-035893; FT-0689136; S0480; Sodium borohydride solution, 3 M in tetraglyme; Sodium borohydride, hydrogen-storage grade, 98%; Sodium borohydride, pellets, diam. 11 mm, 98%; Sodium borohydride, SAJ first grade, >=95.0%; A811099; Sodium borohydride, granular, 10-40 mesh, 98%; Sodium borohydride [UN1426] [Dangerous when wet]; Sodium borohydride [UN1426] [Dangerous when wet]; I14-16064; I14-43078; Sodium borohydride, caplets (18 x 10 x 8 mm), 98%; Sodium borohydride, granular, 99.99% trace metals basis; Sodium borohydride solution, 0.5 M in 2-methoxyethyl ether; Sodium borohydride, purum p.a., >=96% (gas-volumetric); Sodium borohydride solution, SWS, ~12 wt. % in 14 M NaOH; Sodium borohydride, purum, >=97.0% (gas-volumetric), tablet; Sodium borohydride, stable aqueous solution, 4.4M in 14M NaOH; Sodium borohydride solution, 2.0 M in triethylene glycol dimethyl ether; Sodium borohydride, 90% 1303loading,matrixbasic;Sodiumtetrahydridoborate;AF;SBH;Rpn10;NaBH4;BH4Na;borol;VenPure;hidkitexdf;VenPure(R);VenPure? AF; Borate(1-), tetrahydro-, sodium (1:1) [ACD/Index Name]; borohydrure de sodium [French]; NaBH4 [Formula]; Natriumtetrahydroborat [German] [ACD/IUPAC Name]; Sodium borohydride [Wiki]; Sodium tetrahydroborate [ACD/IUPAC Name]; Ttrahydroborate de sodium [French] [ACD/IUPAC Name]; 硼氢化钠 [Chinese]; 16940-66-2 [RN]; 241-004-4 [EINECS]; [16940-66-2]; 137141-62-9 [RN]; 15681-89-7 [RN]; borohydrure de sodium; MFCD00003518; sodium boron(-1) tetrahydride anion; SODIUM TETRAHYDRIDOBORATE; sodium tetrahydridoborate(1-); sodium tetrahydroborate(1-); Sodium, boryl- (9CI); Sodiumborohydride; UNII:87L0B9CPPA; UNII-87L0B9CPPA ; Sodium Tetrahydridoborate; Sodium Tetrahydroborate; Sodium tetrahydridoborate; Sodium tetrahydroborate; MFCD00003518; SBH, Sodium tetrahydroborate; sodium tetrahydroborate; Sodium tetrahydroborate, Hygroscopic, Sodium tetrahydridoborate, VenPure; CAS Number 16940-66-2Molecular Formula NaBH4Molecular Weight 37.83EC Number 241-004-4MDL Number MFCD00003518; Borohydride Sodium; Sodium Tetrahydroborate; Sodium Tetrahydridoborate; Na+ BH4- ; Natriumborhydrid; Borohydrure de Sodium; Sodio Borohydride; 16940-66-2,NaBH4,Sodium tetrahydridoborate; Sodium tetrahydridoborate; SBH, Sodium tetrahydroborate; Sodium Borohydride (crystals) extrapure; chemistry, palladium, borohydride, catalyst, reduction, hydrogenation; chemistry, palladium, borohydride, catalyst, reduction, hydrogenation; NaBH₄; Sodium borohydride , Sodium tetrahydridoborate ; Vegetable fibers Alkaline treatment NaOH Polysaccharide degradation Borohydride ions ; Sodium Borohydride Sodium Borohydride; Sodium borohydride; Potentiometry; Thermodynamic data; Nanosized Nickel Particle, Sodium Borohydride, Phosphating, Oxidation ; sodum borohidrr; sodum ; sodium ; sodum borohyride; sodium boro hyddride; sodum baoro hidrid; SODIUM; SODIUM BOROHYDRIDE; SODUM BOROHYDRDE; SODYUM BOROHDR; SODYUM BOROHYDRR; SODIUM BOROHYDRRIDE; SODUM BOROHYDRIDE; SODIUM BOROHYDRDE; SODIUM BOROHYDDE; SODUM BOROHYDRDE; SODYUM BOROHDRR; Sodium borohydride solution, 2.0 M in triethylene glycol dimethyl ether; Sodium borohydride, 90% NaBH4 basis, pellewloading,matrixbasic;Sodiumtetrahydridoborate;AF;SBH;Rpn10;NaBH4;BH4Na;borol;VenPure;hidkitexdf;VenPure(R);VenPure? AF; Borate(1-), tetrahydro-, sodium (1:1) [ACD/Index Name]; borohydrure de sodium [French]; NaBH4 [Formula]; Natriumtetrahydroborat [German] [ACD/IUPAC Name]; Sodium borohydride [Wiki]; Sodium tetrahydroborate [ACD/IUPAC Name]; Ttrahydroborate de sodium [French] [ACD/IUPAC Name]; 硼氢化钠 [Chinese]; 1694137141-62-9 [RN]; 15681-89-7 [RN]; borohydrure de sodium; MFCD00003518; sodium boron(-1) tetrahydride anion; SODIUM TETRAHYDRIDOBORATE; sodium tetrahydridoborate(1-); sodium tetrahydroborate(1-); Sodium, boryl- (9CI); Sodiumborohydride;Sodium tetrahydroborate,Borol,Sodium borohydrate,Hidkitex DF,Sodium hydroborate,Sodium, boryl- (9CI),Borate(1-), tetrahydro-, sodium,UNII-87L0B9CPPA,Sodium tetrahydroborate(1-),sodium boron(1-),Sodium tetrahydridoborate(1-),Borohydrure de sodium [French],CCRIS 8892,HSDB 699,Sodium borohydride (Na(BH4)),EINECS 241-004-4,UN1426,137141-62-9,MFCD00003518,sodioborohydride,sodium-borohydride,,natrium borohydride,sodiumborhydride,sodium boro-hydride,sodium borohydr-ide,sodium borohydride-,sodium- borohydride,sodium borohydri- de,ACMC-20mwgn,BH4Na,VenPure(R) SF, powder,Sodium borohydride, caplets,87L0B9CPPA,Sodium borohydride, >=95%,Sodium borohydride, 98.0%,Jsp003441,SODIUM BORODEUTERIDE- D4,CTK0H4619,DEWIUSCVDCUJOI-UHFFFAOYSA-UHFFFAOYSAN,ACT09094,AKOS015832967,AKOS015913931,Sodium borohydride, granular, >=98%,OR28836,RTR-035893Sodium borohydride, powder, >=98.0%,AN-15590,IN010199,LS-45014,Sodium borohydride, ReagentPlus(R), 99%,TR-035893,FT-0674616,FT-0689136,S0480,Sodium borohydride solution, 3 M in tetraglyme,Sodium borohydride, hydrogen-storage grade, 98%,Sodium borohydride, pellets, diam. 11 mm, 98%,Sodium borohydride, SAJ first grade, >=95.0%,A811099,Sodium borohydride, granular, 10-40 mesh, 98%,Sodium borohydride [UN1426] [Dangerous when wet],Sodium borohydride [UN1426] [Dangerous when wet],I14-16064,I14-43078,Sodium borohydride, caplets (18 x 10 x 8 mm), 98%,Sodium borohydride, granular, 99.99% trace metals basis,Sodium borohydride solution, 0.5 M in 2-methoxyethyl ether,Sodium borohydride, purum p.a., >=96% (gas-volumetric),Sodium borohydride solution, SWS, ~12 wt. % in 14 M NaOHSodium borohydride, purum, >=97.0% (gas-volumetric), tablet,Sodium borohydride, stable aqueous solution, 4.4M in 14M NaOH,Sodium borohydride solution, 2.0 M in triethylene glycol dimethyl etherSodium borohydride, 90% NaBH4 basis, pellets, diam. 8 mm, Cobalt (Doped),1303-74-8,13034-02-1,24917-15-5,29158-40-5,Sodium borohydride on aluminum oxide, extent of labeling: ~10 wt. % loading, matrix basic alumina support
SODIUM BOROHYDRIDE ;
Occurrence: It is not found as a free compound in nature.
Preparation: Sodium borohydride is prepared from trimethylborate and sodium hydride at elevated temperatures (275 C), in a mineral oil medium. This process is known as method of Schlesinger:
B(OCH3)3 + 4 NaH → NaBH4 + 3 NaOCH3
Physical properties: Sodium b0rohydride is a white to gray, crystalline powder. Its melting and boiling points are >300 and 500 C, respectively. Its density is 1.035 g mL-1. In temperatures higher than 70 C, sodium borohydride may ignite in air (flash point 70 C). It is soluble in lower alcohols and ammonia and insoluble in organic solvents.
Chemical properties: Sodium borohydride reacts easily with water to form sodium hydroxide. Sodium borohydride is a reducing agent that acts selectively. NaBH4 can reduce a carbonyl group presents in aldehydes or ketones to a hydroxyl group without reduces other functional groups present in a molecule, such as amides or esters. It is a reducing agent lesser potent than LiBH4, but NaBH4 is more used to get selective reduction or in reactions in water (LiBH4 reacts violently with water).
Uses: Sodium borohydride is mainly used to reduce aldehydes or ketones to primary or secondary alcohols. It is also used to reduce some inorganic compounds, for example, it is extensively used in process to produce the blenching agent sodium dithionite from sulfur dioxide or to synthesize gold nanoparticles. Sodium borohydride is also the reducing agent used in the reduction of amino acids and their derivatives. It is utilized by pharmaceutical industry in the production of some antibiotics such as chloramphenicol and dihydrostreptomycin.
Health effects/safety hazards: Sodium borohydride may cause skin burn and severe eye burn. It is highly toxic by ingestion. Sodium borohydride may react violently with water. It is also incompatible with oxidizing agents, acids, glass and some metals such as palladium and ruthenium. It is flammable and it burns vigorously.
Abstract
Selective reduction of the carbon-carbon double bond of α,β-unsaturated carbonyl compounds is most commonly and reliably effected using a palladium metal catalyst together with molecular hydrogen from a pressurized tank. Sodium borohydride, like other hydrides, is ordinarily associated with reduction of the more polarized carbonyl of such compounds. However, we have developed an alternative means of employing sodium borohydride in combination with palladium metal to selectively reduce the carbon-carbon double bonds of these compounds. In this survey study, we introduce sodium borohydride as an alternative hydrogen source for such selective, palladium-catalyzed reductions. We also compare the results of this new, heterogeneous borohydride-palladium method with that of traditional palladium-catalyzed hydrogenation. A third method using only sodium borohydride with no palladium is included for comparison.
Product Code :45,288-2
Store at Room Temperature
Product Description:
Molecular Formula: NaBH4
Molecular Weight: 37.83
CAS Number: 16940-66-2
IUPAC NO: Sodium tetrahydridoborate
Sodium borohydride is a white crystalline powder,
packaged in a glass bottle. The bottle is packaged in
a can; the bottle is surrounded by packaging material,
which has the apperance of small white beads.
Sodium borohydride is a very strong reducing agent
used in organic and biochemical reactions.
Sodium borohydride has been used in the study of
glycoprotein receptors. Cell monolayers were treated
with sodium metaperiodate in sodium acetate to
disrupt surface carbohydrates. Cells were then rinsed
with PBS, and reduced with 50 mM sodium
borohydride prepared in PBS (pH 7.4) for 30 minutes
at room temperature.
Precautions and Disclaimer for SODIUM BOROHYDRIDE:
For Laboratory Use Only. Not for drug, household or
other uses.
Preparation Instructions of SODIUM BOROHYDRIDE:
Sodium borohydride is soluble in water, but it reacts
with water. When dissolved in water, hydrogen gas is
formed as a reaction by-product. Hydrogen gas is
extremely flammable.
Storage/Stability for SODIUM BOROHYDRIDE:
Aqueous solutions of sodium borohydride (440 mg/ml)
are most stable in the presence of small amounts of
sodium hydroxide (0.2%); solutions can be kept for
several days.
SODIUM BOROHYDRIDE ;
Oluum: Doada serbest bir bileik olarak bulunmaz.
Hazrlan: Sodyum borohidrid, bir mineral ya ortamnda, yksek scaklklarda (275 C) trimetilborat ve sodyum hidrrden hazrlanr. Bu sre Schlesinger yntemi olarak bilinir:
B (OCH3) 3 + 4 NaH → NaBH4 + 3 NaOCH3
Fiziksel zellikler: Sodyum brohidrit beyazdan griye, kristalin bir tozdur. Erime ve kaynama noktalar srasyla> 300 ve 500 C`dir. Younluu 1.035 g mL-1`dir. 70 C`den yksek scaklklarda, sodyum borohidrit havada tutuabilir (parlama noktas 70 C). Dk alkollerde ve amonyakta znr ve organik zclerde znmez.
Kimyasal zellikler: Sodyum borohidrit, sodyum hidroksit oluturmak iin su ile kolayca reaksiyona girer. Sodyum borohidrit seici olarak etki eden bir indirgeyici maddedir. NaBH4, amidler veya esterler gibi bir moleklde bulunan dier fonksiyonel gruplar azaltmadan aldehitler veya ketonlarda bir hidroksil grubuna sunulan bir karbonil grubunu azaltabilir. LiBH4`ten daha az gl bir indirgeyici maddedir, fakat NaBH4, seici indirgeme veya sudaki reaksiyonlarda daha fazla kullanlr (LiBH4, suyla iddetli reaksiyona girer).
Kullanm Alanlar: Sodyum borohidrit esas olarak aldehitleri veya ketonlar birincil veya ikincil alkollere indirgemek iin kullanlr. Ayn zamanda, baz inorganik bileiklerin azaltlmas iin de kullanlr, rnein, kkrt dioksitten kpk dresyonit sodyum ditionit retmek iin veya altn nanopartiklleri sentezlemek iin yaygn olarak kullanlr. Sodyum borohidrid de amino asitlerin ve bunlarn trevlerinin indirgenmesinde kullanlan indirgeyici bir maddedir. la endstrisi tarafndan kloramfenikol ve dihidrostreptomisin gibi baz antibiyotiklerin retiminde kullanlmaktadr.
Salk etkileri / gvenlik tehlikeleri: Sodyum borohidrit deri yanklarna ve ciddi gz yanklarna neden olabilir. Yutulmasyla olduka zehirlidir. Sodyum borohidrit, suyla iddetli reaksiyona girebilir. Ayrca oksitleyici maddeler, asitler, cam ve paladyum ve rutenyum gibi baz metaller ile de uyumsuzdur. Yancdr ve kuvvetli yanar.
zet
A, y-doymam karbonil bileiklerinin karbon-karbon ift bann seici olarak azaltlmas, bir basnl tanktan molekler hidrojen ile birlikte bir paladyum metal katalizr kullanlarak en yaygn ekilde ve gvenilir ekilde gerekletirilir. Dier hidritler gibi sodyum borohidrid, normalde bu bileiklerin daha polarize edilmi karbonilinin indirgenmesi ile ilikilidir. Bununla birlikte, bu bileiklerin karbon-karbon ift balarn seici olarak azaltmak iin paladyum metali ile kombinasyon halinde sodyum borohidridin kullanld alternatif bir ara gelitirdik. Bu anket almasnda, selektif, paladyum katalizli indirgemeler iin sodyum borohidrr alternatif bir hidrojen kayna olarak tantyoruz. Bu yeni, heterojen borohidrit-paladyum ynteminin sonularn, geleneksel paladyum katalizli hidrojenasyonla karlatryoruz. Karlatrma iin sadece paladyum iermeyen sadece sodyum borohidrit kullanan nc bir yntem eklenmitir.
Sodyum borohidrit, beyaz bir kristal toz olup, bir cam ieye ambalajlanmtr.
ie kutu ierisinde paketlenmitir; ie, kk beyaz boncuklara sahip ambalaj
malzemesi ile evrelenmitir. Sodyum borohidrr, organik ve biyokimyasal reaksiyonlarda
kullanlan ok gl bir indirgeyici ajandr. Sodyum borohidrr glikoprotein reseptrlerinin
almasnda kullanlmtr. Hcre tek tabakalar, yzey karbonhidratlarn bozmak iin
sodyum asetat iinde sodyum metaferiodat ile ilemden geirildi. Hcreler daha sonra PBS
ile alkaland ve PBS`de (pH 7.4) hazrlanan 50 mM sodyum borohidrit ile oda scaklnda
30 dakika indirildi.
SODYUM BORHDRT N NLEMLER :
Sadece Laboratuvar Kullanm in uygundur,Uyuturucu, ev veya
Dier kullanmlar iin uygun deildir.
SODYUM BORHYDRT RETM KILAVUZU:
Sodyum borohidrit su ierisinde znr, ancak su ile reaksiyona girer
. Su ierisinde zndnde, hidrojen gaz
reaksiyon yan rn olarak olumutur. Hidrojen gaz
ok yancdr.
SODYUM BORHDRT N Saklama / Kararllk:
Sodyum borohidritin (440 mg / ml) sulu solsyonlar az miktarda sodyum hidroksit (% 0.2) varlnda
en kararldr; zeltiler birka gn boyunca tutulabilir.