TYLOSE MH 2000 YP2
TYLOSE MH 2000 YP2
CAS No. : 9004-62-0
EC No. : 618-387-5
Synonyms:
TYLOSE MH 2000 YPS; Hydroxyethyl cellulose; 9004-62-0; Hespan; Plasmasteril; Pentaspan; Hespander; Onkohas; Voluven; Hespander injection; HAS [German]; Penford 260; Penford 280; Penford 290; Ethylex gum 2020; Penford P 208; Essex gum 1360; Essex 1360; TYLOSE MH 2000 YPS [USAN:BAN]; Pentastarch [USAN:BAN]; O-(2-Hydroxyethyl)starch; Hydroxyathylstarke [German]; 2-Hydroxyethyl starch ether; Starch 2-hydroxyethyl ether; Tapioca starch hydroxyethyl ether; ASL 607; DTXSID60873934; VZ36173; LS-146657; FT-0627136; NS00007183; hydroxyethyl cellulose;HYDROXYETHYLCELLULOSE;hydroxyethylcellulose; 2-O-(2-Hydroxyethyl)-4-O-methylhexopyranosyl-(1->4)-[4-O-methylhexopyranosyl-(1->6)]hexopyranosyl-(1->5)-2,6-anhydro-1-deoxyheptitol; A starch composed of more than 90% amylopectin that has been etherified to the extent that an average of 4 to 5 of the OH groups present in every 10 D-glucopyranose units of the starch polymer have been converted to OCH2CH2OH groups. Starch 2-hydroxyethyl ether; TYLOSE MH 2000 YP2; tylose mh; tilose mh 2000 yp2; TILOSE MH 2000 YPS2; TYLOSE 2000; TYLOSE MH 2000 YPS; Hydroxyethyl cellulose; 9004-62-0; Hespan; Plasmasteril; Pentaspan; Hespander; Onkohas; Voluven; Hespander injection; HAS [German]; Penford 260; Penford 280; Penford 290; Ethylex gum 2020; Penford P 208; Essex gum 1360; Essex 1360; TYLOSE MH 2000 YPS [USAN:BAN]; Pentastarch [USAN:BAN]; O-(2-Hydroxyethyl)starch; Hydroxyathylstarke [German]; 2-Hydroxyethyl starch ether; Starch 2-hydroxyethyl ether; Tapioca starch hydroxyethyl ether; ASL 607; DTXSID60873934; VZ36173; LS-146657; FT-0627136; NS00007183; hydroxyethyl cellulose;HYDROXYETHYLCELLULOSE;hydroxyethylcellulose; 2-O-(2-Hydroxyethyl)-4-O-methylhexopyranosyl-(1->4)-[4-O-methylhexopyranosyl-(1->6)]hexopyranosyl-(1->5)-2,6-anhydro-1-deoxyheptitol; A starch composed of more than 90% amylopectin that has been etherified to the extent that an average of 4 to 5 of the OH groups present in every 10 D-glucopyranose units of the starch polymer have been converted to OCH2CH2OH groups. Starch 2-hydroxyethyl ether; TYLOSE MH 2000 YP2; tylose mh; tilose mh 2000 yp2; TILOSE MH 2000 YPS2; TYLOSE 2000; TYLOSE MH 2000 YPS; Hydroxyethyl cellulose; 9004-62-0; Hespan; Plasmasteril; Pentaspan; Hespander; Onkohas; Voluven; Hespander injection; HAS [German]; Penford 260; Penford 280; Penford 290; Ethylex gum 2020; Penford P 208; Essex gum 1360; Essex 1360; TYLOSE MH 2000 YPS [USAN:BAN]; Pentastarch [USAN:BAN]; O-(2-Hydroxyethyl)starch; Hydroxyathylstarke [German]; 2-Hydroxyethyl starch ether; Starch 2-hydroxyethyl ether; Tapioca starch hydroxyethyl ether; ASL 607; DTXSID60873934; VZ36173; LS-146657; FT-0627136; NS00007183; hydroxyethyl cellulose;HYDROXYETHYLCELLULOSE;hydroxyethylcellulose; 2-O-(2-Hydroxyethyl)-4-O-methylhexopyranosyl-(1->4)-[4-O-methylhexopyranosyl-(1->6)]hexopyranosyl-(1->5)-2,6-anhydro-1-deoxyheptitol; A starch composed of more than 90% amylopectin that has been etherified to the extent that an average of 4 to 5 of the OH groups present in every 10 D-glucopyranose units of the starch polymer have been converted to OCH2CH2OH groups. Starch 2-hydroxyethyl ether; TYLOSE MH 2000 YP2; tylose mh; tilose mh 2000 yp2; TILOSE MH 2000 YPS2; TYLOSE 2000; TYLOSE MH 2000 YPS; Hydroxyethyl cellulose; 9004-62-0; Hespan; Plasmasteril; Pentaspan; Hespander; Onkohas; Voluven; Hespander injection; HAS [German]; Penford 260; Penford 280; Penford 290; Ethylex gum 2020; Penford P 208; Essex gum 1360; Essex 1360; TYLOSE MH 2000 YPS [USAN:BAN]; Pentastarch [USAN:BAN]; O-(2-Hydroxyethyl)starch; Hydroxyathylstarke [German]; 2-Hydroxyethyl starch ether; Starch 2-hydroxyethyl ether; Tapioca starch hydroxyethyl ether; ASL 607; DTXSID60873934; VZ36173; LS-146657; FT-0627136; NS00007183; hydroxyethyl cellulose;HYDROXYETHYLCELLULOSE;hydroxyethylcellulose; 2-O-(2-Hydroxyethyl)-4-O-methylhexopyranosyl-(1->4)-[4-O-methylhexopyranosyl-(1->6)]hexopyranosyl-(1->5)-2,6-anhydro-1-deoxyheptitol; A starch composed of more than 90% amylopectin that has been etherified to the extent that an average of 4 to 5 of the OH groups present in every 10 D-glucopyranose units of the starch polymer have been converted to OCH2CH2OH groups. Starch 2-hydroxyethyl ether; TYLOSE MH 2000 YP2; tylose mh; tilose mh 2000 yp2; TILOSE MH 2000 YPS2; TYLOSE 2000; TYLOSE MH 2000 YPS; Hydroxyethyl cellulose; 9004-62-0; Hespan; Plasmasteril; Pentaspan; Hespander; Onkohas; Voluven; Hespander injection; HAS [German]; Penford 260; Penford 280; Penford 290; Ethylex gum 2020; Penford P 208; Essex gum 1360; Essex 1360; TYLOSE MH 2000 YPS [USAN:BAN]; Pentastarch [USAN:BAN]; O-(2-Hydroxyethyl)starch; Hydroxyathylstarke [German]; 2-Hydroxyethyl starch ether; Starch 2-hydroxyethyl ether; Tapioca starch hydroxyethyl ether; ASL 607; DTXSID60873934; VZ36173; LS-146657; FT-0627136; NS00007183; hydroxyethyl cellulose;HYDROXYETHYLCELLULOSE;hydroxyethylcellulose; 2-O-(2-Hydroxyethyl)-4-O-methylhexopyranosyl-(1->4)-[4-O-methylhexopyranosyl-(1->6)]hexopyranosyl-(1->5)-2,6-anhydro-1-deoxyheptitol; A starch composed of more than 90% amylopectin that has been etherified to the extent that an average of 4 to 5 of the OH groups present in every 10 D-glucopyranose units of the starch polymer have been converted to OCH2CH2OH groups. Starch 2-hydroxyethyl ether; TYLOSE MH 2000 YP2; tylose mh; tilose mh 2000 yp2; TILOSE MH 2000 YPS2; TYLOSE 2000; TYLOSE MH 2000 YPS; Hydroxyethyl cellulose; 9004-62-0; Hespan; Plasmasteril; Pentaspan; Hespander; Onkohas; Voluven; Hespander injection; HAS [German]; Penford 260; Penford 280; Penford 290; Ethylex gum 2020; Penford P 208; Essex gum 1360; Essex 1360; TYLOSE MH 2000 YPS [USAN:BAN]; Pentastarch [USAN:BAN]; O-(2-Hydroxyethyl)starch; Hydroxyathylstarke [German]; 2-Hydroxyethyl starch ether; Starch 2-hydroxyethyl ether; Tapioca starch hydroxyethyl ether; ASL 607; DTXSID60873934; VZ36173; LS-146657; FT-0627136; NS00007183; hydroxyethyl cellulose;HYDROXYETHYLCELLULOSE;hydroxyethylcellulose; 2-O-(2-Hydroxyethyl)-4-O-methylhexopyranosyl-(1->4)-[4-O-methylhexopyranosyl-(1->6)]hexopyranosyl-(1->5)-2,6-anhydro-1-deoxyheptitol; A starch composed of more than 90% amylopectin that has been etherified to the extent that an average of 4 to 5 of the OH groups present in every 10 D-glucopyranose units of the starch polymer have been converted to OCH2CH2OH groups. Starch 2-hydroxyethyl ether; TYLOSE MH 2000 YP2; tylose mh; tilose mh 2000 yp2; TILOSE MH 2000 YPS2; TYLOSE 2000;
EN
TYLOSE MH 2000 YP2 IUPAC Name 5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol
TYLOSE MH 2000 YP2 InChI InChI=1S/C29H52O21/c1-10-15(34)16(35)24(13(8-33)45-10)49-28-20(39)18(37)25(50-29-26(43-5-4-30)21(40)23(42-3)12(7-32)47-29)14(48-28)9-44-27-19(38)17(36)22(41-2)11(6-31)46-27/h10-40H,4-9H2,1-3H3
TYLOSE MH 2000 YP2 InChI Key CWSZBVAUYPTXTG-UHFFFAOYSA-N
TYLOSE MH 2000 YP2 Canonical SMILES CC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)COC3C(C(C(C(O3)CO)OC)O)O)OC4C(C(C(C(O4)CO)OC)O)OCCO)O)O)O)O
TYLOSE MH 2000 YP2 Molecular Formula (C2H602)x
TYLOSE MH 2000 YP2 CAS 9004-62-0
TYLOSE MH 2000 YP2 European Community (EC) Number 618-387-5
TYLOSE MH 2000 YP2 ICSC Number 1559
TYLOSE MH 2000 YP2 RTECS Number FJ5958000
TYLOSE MH 2000 YP2 Physical Description WHITE POWDER.
TYLOSE MH 2000 YP2 Solubility Solubility in water: good
TYLOSE MH 2000 YP2 Autoignition Temperature 380 °C
TYLOSE MH 2000 YP2 Molecular Weight 736.7 g/mol
TYLOSE MH 2000 YP2 XLogP3-AA -7.7
TYLOSE MH 2000 YP2 Hydrogen Bond Donor Count 11
TYLOSE MH 2000 YP2 Hydrogen Bond Acceptor Count 21
TYLOSE MH 2000 YP2 Rotatable Bond Count 15
TYLOSE MH 2000 YP2 Exact Mass 736.300109 g/mol
TYLOSE MH 2000 YP2 Monoisotopic Mass 736.300109 g/mol
TYLOSE MH 2000 YP2 Topological Polar Surface Area 315 Ų
TYLOSE MH 2000 YP2 Heavy Atom Count 50
TYLOSE MH 2000 YP2 Formal Charge 0
TYLOSE MH 2000 YP2 Complexity 999
TYLOSE MH 2000 YP2 Isotope Atom Count 0
TYLOSE MH 2000 YP2 Defined Atom Stereocenter Count 0
TYLOSE MH 2000 YP2 Undefined Atom Stereocenter Count 20
TYLOSE MH 2000 YP2 Defined Bond Stereocenter Count 0
TYLOSE MH 2000 YP2 Undefined Bond Stereocenter Count 0
TYLOSE MH 2000 YP2 Covalently-Bonded Unit Count 1
TYLOSE MH 2000 YP2 Compound Is Canonicalized Yes
Tylose® MHEC (methyl hydroxyethyl cellulose/Tylose MH-grades) are water soluble, nonionic cellulose ethers, which are offered as free flowing powder or in granular form. Tylose MHEC may contain further additives which for example control the dissolution behavior or the thickening power.Methylhydroxyethyl cellulose. Offers very high water retention, low gloss, low pigment compatibility, low pseudoplasticity, moderate thickening effect, and moderate wet scrub resistance. Exhibits good anti-spattering. Used for paint applications like solid paints, powder paints, limewash paints, cement paints, distempers, and emulsion based plasters.Tylose® MH 2000 YP2 is a water-soluble, non-ionic methyl hydroxyethyl cellulose powder with standard etherification. It provides increased biostability, low gloss appearance, good anti-spattering properties, and moderate wet scrub resistance. This grade of methyl hydroxyethyl cellulose (MHEC) is ideal for use in cement paints, distempers, and lime-wash paints.Constitution: Methyl hydroxyethyl cellulose Appearance:powder Etherification:standard Particle size:powder Delayed solubility:yes Level of viscosity:2000 mPa•sTYLOSE MH 2000 YP2 Biostability:yes TYLOSE MH 2000 YP2 Gloss:low TYLOSE MH 2000 YP2 Pigment Compatibility:low TYLOSE MH 2000 YP2 Anti-spattering:good TYLOSE MH 2000 YP2 Pseudoplasticity:low TYLOSE MH 2000 YP2 Thickening effect:low TYLOSE MH 2000 YP2 Wet scrub resistance:moderate TYLOSE MH 2000 YP2 Water retention:lowCementitious thin bed adhesives are used to adhere ceramic tiles, to build walls of aerated concrete or lime stone bricks and to install exterior insulating finishing systems(EIFS). They offer an easy and light workability,a high efficiency and guarantee a long durability.Cement tile adhesives have to be easy to trowel. They must provide long embedding time, high slip resistance and sufficient adhesion strength. These properties can be influenced by Tylose® MC. Adhesives for block laying are used to build up walls of aerated concrete blocks, sand-lime bricks or standard bricks. EIFS adhesives ensure an excellent bond between substrate and insulating boards. Tylose MC improves the workability of EIFS adhesives and increases both adhesion and sag resistance.Renders are mixtures of mineral binders, aggregates and auxiliaries. Depending on the process, there is a distinction between hand and machine application.Renders are used for base coating, insulation, renovation and decorative purposes. Renders based on cement or cement/hydrated lime can be employed for exterior and interior work.Cement based jointing and trowelling compounds are used for repairing systems and to smooth coarse walls and floors. Grouts are applied to fill the gaps between ceramic or stone tiles.Tylose MC is an important additive ensuring there is sufficient water retention in renders and trowelling compounds. Additional advantages are better workability and an increase of the adhesion strength.Machine applied renders are mixed in continuously or discontinuously working plastering machines.These enable coverage of large wall and ceiling areas by a highly efficient technique. Continuously operating plastering machines need to be fed with premixed renders containing Tylose. Other additives can be added as required.What is TYLOSE MH 2000 YPS? TYLOSE MH 2000 YPS (hydroxyethyl starch) is made from natural sources of starch. TYLOSE MH 2000 YPS increases the volume of blood plasma that can be lost from bleeding or severe injury. Plasma is needed to circulate red blood cells that deliver oxygen throughout the body.TYLOSE MH 2000 YPS is used to treat or prevent hypovolemia (decreased blood plasma volume, also called “shock”) that may occur as a result of serious injury, surgery, severe blood loss, burns, or other trauma.TYLOSE MH 2000 YPS may also be used for purposes not listed in this medication guide.Important Information You should not receive this medication if you have a bleeding or blood clotting disorder, congestive heart failure, kidney disease, or urination problems not caused by hypovolemia (decreased blood plasma volume).TYLOSE MH 2000 YPS can harm your kidneys. Call your doctor at once if you have any of these symptoms of kidney damage: swelling, rapid weight gain, unusual tiredness, nausea, vomiting, feeling short of breath, red or pink urine, painful or difficult urination, or little or no urinating.Before taking this medicine You should not receive this medication if you are allergic to TYLOSE MH 2000 YPS, or if you have:a bleeding or blood clotting disorder;kidney disease;congestive heart failure; or urination problems not caused by hypovolemia (decreased blood plasma volume).If possible before you receive TYLOSE MH 2000 YPS, tell your doctor if you have:liver disease;a history of heart disease; or if you are allergic to corn.FDA pregnancy category C. It is not known whether TYLOSE MH 2000 YPS will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.It is not known whether TYLOSE MH 2000 YPS passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.In an emergency situation it may not be possible to tell your caregivers about your health conditions, or if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received TYLOSE MH 2000 YPS.How is TYLOSE MH 2000 YPS given?TYLOSE MH 2000 YPS is injected into a vein through an IV. A healthcare provider will give you this injection.Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely while you are receiving TYLOSE MH 2000 YPS. Your blood will also need to be tested daily during treatment.What happens if I miss a dose?Because you will receive TYLOSE MH 2000 YPS in a clinical setting, you are not likely to miss a dose.What happens if I overdose?Since TYLOSE MH 2000 YPS is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.What should I avoid after receiving TYLOSE MH 2000 YPS?Follow your doctor’s instructions about any restrictions on food, beverages, or activity.TYLOSE MH 2000 YPS side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.Tell your caregivers right away if you have:wheezing or gasping for breath, rapid breathing, sweating, and anxiety;a light-headed feeling, like you might pass out;weak pulse, slow breathing;chest pain, fever, chills, cough; or easy bruising, unusual bleeding, or any bleeding that will not stop.Rare but serious side effects may include:severe headache, vision or speech problems, mental changes;drooping eyelids, loss of feeling in your face, tremors, trouble swallowing; or severe skin reaction — fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.TYLOSE MH 2000 YPS can harm your kidneys. Call your doctor at once if you have any of these symptoms of kidney damage: swelling, rapid weight gain, unusual tiredness, nausea, vomiting, feeling short of breath, red or pink urine, painful or difficult urination, or little or no urinating.Common side effects may include:mild itching or skin rash;mild headache;muscle pain; or swollen glands, mild flu symptoms.This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.See also:TYLOSE MH 2000 YPS side effects (in more detail)TYLOSE MH 2000 YPS dosing information Usual Adult Dose for Hypovolemia:Dosage for Acute Use in Plasma Volume Expansion: 500 to 1000 mL IVMaintenance dose: Total dosage and rate of infusion depends on the amount of blood or plasma lost and the resultant hemoconcentration.Maximum dose: Doses more than 1500 mL per day (approximately 20 mL per kg of body weight) are usually not required although higher doses have been used in postoperative and trauma patients with severe blood loss.Dosage in Leukapheresis: 250 to 700 mL to which citrate anticoagulant has been added and administered to the input line of the centrifugation apparatus at a ratio of 1:8 to 1:13 to venous whole blood.Comments:TYLOSE MH 2000 YPS and citrate should be thoroughly mixed to assure effective anticoagulation.TYLOSE MH 2000 YPS admixtures of 500 to 560 mL with citrate concentrations up to 2.5% are compatible for 24 hours at room temperature.Uses:For treatment of hypovolemia when plasma volume expansion is desired.This drug in leukapheresis improves the harvesting and increasing the yield of granulocytes by centrifugal means.What other drugs will affect TYLOSE MH 2000 YPS? Other drugs may interact with TYLOSE MH 2000 YPS, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.Further information Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Pharmacology and mechanism of action Pentastarch is a synthetic colloid volume expander that is used to maintain vascular volume in animals with circulatory shock. It is prepared from hydroxyethyl starch and is derived from amylopectin. There are two hydroxyethyl starch preparations: TYLOSE MH 2000 YPS and pentastarch. TYLOSE MH 2000 YPS (6%) has an average molecular weight of 450,000 and colloid osmotic pressure of 32.7. Pentastarch (10%) has an average molecular weight of 280,000 and colloid osmotic pressure of 40. Because TYLOSE MH 2000 YPS is a larger molecular weight compound than pentastarch, it tends to remain in the vasculature and prevent loss of intravascular volume and tissue edema. After administration, pentastarch will be retained in the vasculature and prevent loss of intravascular volume and tissue edema. Other colloids used are dextrans (Dextran 40 and Dextran 70). TYLOSE MH 2000 YPS and the dextrans are discussed in other sections.Pharmacology and mechanism of action Hydroxyethyl starch is a synthetic colloid volume expander that is used to maintain vascular volume in animals with circulatory shock. It is a modified branched-chain glucose polymer derived from amylopectin sources such as potatoes, sorghum, or maize. The hydroxyethyl starch preparations include tetrastarch, TYLOSE MH 2000 YPS, and pentastarch. TYLOSE MH 2000 YPS (6%) has an average molecular weight of 200 kDa (kilodaltons) and a colloid osmotic pressure of approximately 30. Pentastarch (10%) has an average molecular weight of 200 kDa and a colloid osmotic pressure of 30-60. Tetrastarch (VetStarch) 6% has a molecular weight of 130 kDa and a colloid osmotic pressure of 36. The number of molecular substitutions determine whether it is TYLOSE MH 2000 YPS, pentastarch, or hexastarch. TYLOSE MH 2000 YPS has the most molecular substitutions and tends to remain longest in the vasculature. TYLOSE MH 2000 YPS is cleared much more slowly than tetrastarch. Although TYLOSE MH 2000 YPS is prevented from hydrolysis in blood, thereby prolonging intravascular expansion, this property also is associated with accumulation in the reticuloendothelial system, skin, liver, and kidney.TYLOSE MH 2000 YPS is a more cost-effective synthetic colloid. Advantages of TYLOSE MH 2000 YPS include maintenance of plasma oncotic effect for up to 24 hours following administration and the ability to give as a rapid bolus.10,11 However, unlike plasma, there are no functional proteins present in hydroxyethyl starch solutions and a negative effect on coagulation has been demonstrated in healthy equids.10,12 Further, a 2013 review of the use of colloids as volume replacement in critically ill humans found an increased risk of mortality and acute kidney injury in patients receiving TYLOSE MH 2000 YPS.13 As such, the use of TYLOSE MH 2000 YPS in horses with underlying renal insufficiency is cautioned, and its use is restricted to those with clinical signs of acute hypoproteinemia. Recently tetrastarch (6%) was evaluated and shown to have a more sustained effect on COP with fewer adverse coagulopathic effects than TYLOSE MH 2000 YPS.14 Both TYLOSE MH 2000 YPS and tetrastarch can be dosed at 10 mL/kg.
TR
TYLOSE MH 2000 YP2 IUPAC Ad 5- [6 – [[3,4-dihidroksi-6- (hidroksimetil) -5-metoksioksan-2-il] oksimetil] -3,4-dihidroksi-5- [4-hidroksi-3 – (2-hidroksietoksi) -6- (hidroksimetil) -5-metoksioksan-2-il] oksioksan-2-il] oksi-6- (hidroksimetil) -2-metiloksan-3,4-diol
TYLOSE MH 2000 YP2 InChI InChI = 1S / C29H52O21 / c1-10-15 (34) 16 (35) 24 (13 (8-33) 45-10) 49-28-20 (39) 18 (37) 25 (50 -29-26 (43-5-4-30) 21 (40) 23 (42-3) 12 (7-32) 47-29) 14 (48-28) 9-44-27-19 (38) 17 (36) 22 (41-2) 11 (6-31) 46-27 / h10-40H, 4-9H2,1-3H3
TYLOSE MH 2000 YP2 InChI Anahtar CWSZBVAUYPTXTG-UHFFFAOYSA-N
TYLOSE MH 2000 YP2 Kanonik SMILES CC1C (C (C (C (O1) CO) OC2C (C (C (C (O2)) COC3C (C (C (C (O3))) OC) O) O) OC4C (C ( C (C (O4) CO) OC) O) OCCO) O) O) O) O
TYLOSE MH 2000 YP2 Moleküler Formül (C2H602) x
TYLOSE MH 2000 YP2 CAS 9004-62-0
TYLOSE MH 2000 YP2 Avrupa Topluluu (EC) Numaras 618-387-5
TYLOSE MH 2000 YP2 ICSC Numaras 1559
TYLOSE MH 2000 YP2 RTECS Numaras FJ5958000
TYLOSE MH 2000 YP2 Fiziksel Tanm BEYAZ POWDER.
TYLOSE MH 2000 YP2 Çözünürlük Suda çözünürlük: iyi
TYLOSE MH 2000 YP2 Kendiliinden Tutuma Scakl 380 ° C
TYLOSE MH 2000 YP2 Molekül Arl 736.7 g / mol
TYLOSE MH 2000 YP2 XLogP3-AA -7.7
TYLOSE MH 2000 YP2 Hidrojen Ba Donör Says 11
TYLOSE MH 2000 YP2 Hidrojen Ba Alcs Says 21
TYLOSE MH 2000 YP2 Dönebilen Tahvil Says 15
TYLOSE MH 2000 YP2 Tam Kütle 736.300109 g / mol
TYLOSE MH 2000 YP2 Monoizotopik Kütle 736.300109 g / mol
TYLOSE MH 2000 YP2 Topolojik Polar Yüzey Alan 315 Ų
TYLOSE MH 2000 YP2 Ar Atom Says 50
TYLOSE MH 2000 YP2 Resmi Ücret 0
TYLOSE MH 2000 YP2 Karmaklk 999
TYLOSE MH 2000 YP2 zotop Atom Says 0
TYLOSE MH 2000 YP2 Tanml Atom Stereocenter Says 0
TYLOSE MH 2000 YP2 Tanmsz Atom Stereocenter Says 20
TYLOSE MH 2000 YP2 Tanml Bond Stereocenter Says 0
TYLOSE MH 2000 YP2 Tanmsz Ba Stereocenter Says 0
TYLOSE MH 2000 YP2 Kovalent Bal Birim Says 1
TYLOSE MH 2000 YP2 Bileii Kanonikletirilmitir Evet
Tylose® MHEC (metil hidroksietil selüloz / Tylose MH snflar), serbest akl toz veya granüler formda sunulan suda çözünür, noniyonik selüloz eterlerdir. Tylose MHEC, örnein çözünme davrann veya koyulatrma gücünü kontrol eden baka katk maddeleri içerebilir. Metilhidroksietil selüloz. Çok yüksek su tutma, düük parlaklk, düük pigment uyumluluu, düük pseudoplastiklik, orta kalnlama etkisi ve orta derecede slak ovalama direnci sunar. yi bir anti-sçrama sergiler. Kat boyalar, toz boyalar, kireçli boyalar, çimento boyalar, distempers ve emülsiyon bazl svalar gibi boya uygulamalar için kullanlr. Tylose® MH 2000 YP2, standart eterletirmeye sahip, suda çözünür, iyonik olmayan bir metil hidroksietil selüloz tozudur. Arttrlm biyolojik kararllk, düük parlaklk görünümü, iyi sçrama önleyici özellikler ve orta derecede slak ovalama direnci salar. Bu tip metil hidroksietil selüloz (MHEC) çimento boyalarnda, distemperslerde ve kireç ykama boyalarnda kullanm için idealdir. Yap: Metil hidroksietil selüloz Görünüm: toz Eterifikasyon: standart Partikül boyutu: toz Gecikmi çözünürlük: evet Viskozite seviyesi: 2000 mPa • sTYLOSE MH 2000 YP2 Biyostabilite: evet TYLOSE MH 2000 YP2 Parlak: düük TYLOSE MH 2000 YP2 Pigment Uyumluluu: düük TYLOSE MH 2000 YP2 Sçrama önleyici: iyi TYLOSE MH 2000 YP2 Pseudoplastikite: düük TYLOSE MH 2000 YP2 Kalnlama etkisi: düük TYLOSE MH 2000 YP2 Islak ovma direnci: orta TYLOSE MH 2000 YP2 Su tutma: Düük Çimento esasl ince yatakl yaptrclar, seramik karolar yaptrmak, gazbeton veya kireç ta tulalardan duvarlar ina etmek ve d cephe yaltm bitirme sistemleri (EIFS) kurmak için kullanlr. Kolay ve hafif bir ilenebilirlik, yüksek bir verimlilik sunarlar ve uzun bir dayankll garanti ederler. Çimento karo yaptrclarnn perdahlanmas kolay olmaldr. Uzun gömme süresi, yüksek kayma direnci ve yeterli yapma mukavemeti salamaldrlar. Bu özellikler Tylose® MC’den etkilenebilir. Blok döeme için yaptrclar, gaz beton bloklarn, kum-kireç tulalarnn veya standart tulalarn duvarlarn oluturmak için kullanlr. EIFS yaptrclar, alt tabaka ve yaltm levhalar arasnda mükemmel bir ba salar. Tylose MC, EIFS yaptrclarnn ilenebilirliini iyiletirir ve hem yapma hem de sarkma direncini artrr. Renderler, mineral balayclar, agregalar ve yardmclarn karmlardr. leme bal olarak el ve makine uygulamas arasnda bir ayrm vardr.Renderler taban kaplama, izolasyon, yenileme ve dekoratif amaçl kullanlr. Çimento veya çimento / sönmü kireç esasl svalar, d ve iç iler için kullanlabilir. Çimento esasl birletirme ve mala bileikleri, sistemleri onarmak ve kaba duvar ve zeminleri düzletirmek için kullanlr. Harçlar, seramik veya ta karolar arasndaki boluklar doldurmak için uygulanr. Tylose MC, sva ve mala bileenlerinde yeterli su tutmay salayan önemli bir katk maddesidir. Dier avantajlar daha iyi ilenebilirlik ve yapma mukavemetinin artmasdr.Makine uygulanan svalar sürekli veya aralkl çalan sva makinelerinde kartrlr.Bu, geni duvar ve tavan alanlarnn yüksek verimli bir teknikle kapatlmasn salar. Sürekli çalan sva makinelerinin Tylose içeren önceden kartrlm svalarla beslenmesi gerekir. Dier katk maddeleri gerektii gibi eklenebilir. TYLOSE MH 2000 YPS nedir? TYLOSE MH 2000 YPS (hidroksietil niasta) doal niasta kaynaklarndan yaplr. TYLOSE MH 2000 YPS, kanama veya ciddi yaralanma nedeniyle kaybedilebilen kan plazmas hacmini artrr. Vücuda oksijen veren krmz kan hücrelerini dolatrmak için plazmaya ihtiyaç vardr. TYLOSE MH 2000 YPS, ciddi yaralanma, ameliyat, ameliyat ve yaralanma sonucu oluabilecek hipovolemiyi (azalm kan plazma hacmi, “ok” olarak da adlandrlr) tedavi etmek veya önlemek için kullanlr. Ar kan kayb, yanklar veya dier travmalar TYLOSE MH 2000 YPS, bu ilaç klavuzunda listelenmemi amaçlar için de kullanlabilir Önemli Bilgiler Kanama veya kan phtlama bozukluunuz, konjestif kalp yetmezliiniz, böbrek varsa bu ilac almamalsnz hastalk veya hipovoleminin neden olmad idrara çkma sorunlar (azalm kan plazma hacmi). TYLOSE MH 2000 YPS böbreklerinize zarar verebilir. Bu böbrek hasar belirtilerinden herhangi birine sahipseniz hemen doktorunuzu arayn: ime, hzl kilo alma, allmadk yorgunluk, bulant, kusma, nefes darl, krmz veya pembe idrar, arl veya zor idrara çkma veya çok az veya hiç idrar yapma. Bu ilac almadan önce TYLOSE MH 2000 YPS’ye alerjiniz varsa veya aadaki durumlarda bu ilac almamalsnz: kanama veya kan phtlama bozukluu, böbrek hastal, konjestif kalp yetmezlii; veya hipovoleminin neden olmad idrara çkma sorunlar (azalm kan plazma hacmi). Mümkünse, TYLOSE MH 2000 YPS’yi almadan önce doktorunuza söyleyin: karacier hastalnz; kalp hastal öyküsü; veya msra alerjiniz varsa FDA gebelik kategorisi C. TYLOSE MH 2000 YPS’nin domam bir bebee zarar verip vermeyecei bilinmemektedir. Hamileyseniz veya hamile kalmay planlyorsanz doktorunuza söyleyin.TYLOSE MH 2000 YPS’nin anne sütüne geçip geçmedii veya emzirilen bebee zarar verebilecei bilinmemektedir. Bir bebei emziriyorsanz doktorunuza söyleyin Acil bir durumda bakclarnza salk durumunuz hakknda veya hamileyseniz veya emziriyorsanz anlatmanz mümkün olmayabilir. Gebeliinizle ilgilenen herhangi bir doktorun veya bebeinizin TYLOSE MH 2000 YPS aldnz bildiinden emin olun. TYLOSE MH 2000 YPS nasl verilir? TYLOSE MH 2000 YPS, IV yoluyla damara enjekte edilir. Bir salk kuruluu size bu enjeksiyonu verecektir. TYLOSE MH 2000 YPS alrken nefes alp vermeniz, kan basncnz, oksijen seviyeleriniz, böbrek fonksiyonunuz ve dier hayati belirtileriniz yakndan izlenecektir. Tedavi srasnda kannzn da günlük olarak test edilmesi gerekecektir.Bir dozu kaçrrsam ne olur? Klinik bir ortamda TYLOSE MH 2000 YPS alacanz için bir dozu kaçrma olaslnz yoktur.Ar doz alrsam ne olur? MH 2000 YPS, tbbi bir ortamda bir salk uzman tarafndan verilir, ar doz olumas olas deildir. TYLOSE MH 2000 YPS aldktan sonra nelerden kaçnmalym? Yiyecek, içecek veya aktivite ile ilgili herhangi bir kstlama hakknda doktorunuzun talimatlarn izleyin. TYLOSE MH 2000 YPS yan etkileri Aadaki alerjik reaksiyon belirtilerinden herhangi birine sahipseniz acil tbbi yardm aln: kurdeen; nefes almada zorluk; Yüzünüzün, dudaklarnzn, dilinizin veya boaznzn imesi: unlara sahipseniz hemen bakclarnza söyleyin: nefes almak için hrltl solunum, hzl nefes alma, terleme ve anksiyete; söndüünüz gibi hafif bal bir his; zayf nabz, yava nefes alma; göüs ars, ate, titreme, öksürük; veya kolay morarma, olaand kanama veya durmayacak herhangi bir kanama. Nadir fakat ciddi yan etkiler unlar içerebilir: iddetli ba ars, görme veya konuma sorunlar, zihinsel deiiklikler; göz kapaklarnn sarkmas, yüzünüzde his kayb, titreme, yutma güçlüü; veya iddetli cilt reaksiyonu – ate, boaz ars, yüzünüzde veya dilinizde ime, gözlerde yanma, cilt ars, ardndan yaylan krmz veya mor deri döküntüsü (özellikle yüz veya vücudun üst ksmnda) kabarma ve soyulmaya neden olur .TYLOSE MH 2000 YPS böbreklerinize zarar verebilir. Bu böbrek hasar belirtilerinden herhangi birine sahipseniz derhal doktorunuzu arayn: ime, hzl kilo alma, olaand yorgunluk, bulant, kusma, nefes darl, krmz veya pembe idrar, arl veya zor idrara çkma veya çok az veya hiç idrar yapma. Yaygn yan etkiler unlar içerebilir: hafif kant veya deri döküntüsü; hafif ba ars; kas ars; veya imi bezler, hafif grip semptomlar Bu, yan etkilerin tam listesi deildir ve dierleri meydana gelebilir. Yan etkilerle ilgili tbbi tavsiye için doktorunuzu arayn.Ayrca baknz: TYLOSE MH 2000 YPS yan etkileri (daha ayrntl olarak) TYLOSE MH 2000 YPS doz bilgisi Hipovolemi için Normal Yetikin Dozu: Plazma Hacim Genilemesinde Akut Kullanm Dozu: 500-1000 mL IV Bakm doz: Toplam dozaj ve infüzyon hz, kaybedilen kan veya plazma miktarna ve sonuçta ortaya çkan hemokonsantrasyona baldr.Maksimum doz: Günde 1500 mL’den fazla dozlar (vücut arlnn kilogram bana yaklak 20 mL) genellikle gerekli deildir, ancak daha yüksek dozlar ar kan kayb olan postoperatif ve travma hastalarnda kullanlmtr. Lökaferez dozaj: 250 ila 700 mL sitrat antikoagülan eklenmi ve santrifüj aparatnn giri hattna venöze 1: 8 ila 1:13 orannda uygulanmtr. Tam kan. veya oda scaklnda 24 saat. Kullanmlar: Plazma hacmi genilemesi istendiinde hipovoleminin tedavisi için. Lökaferezdeki bu ilaç, santrifüj yoluyla granülositlerin hasat edilmesini ve verimini arttrr. Reçeteli ve reçetesiz satlan ilaçlar, vitaminler ve bitkisel ürünler dahil olmak üzere dier ilaçlar TYLOSE MH 2000 YPS ile etkileime girebilir. u anda kullandnz tüm ilaçlar ve kullanmaya baladnz veya kullanmay braktnz ilaçlar her bir salk hizmeti salaycnza anlatn Daha fazla bilgi Unutmayn, bunu ve dier tüm ilaçlar çocuklarn eriemeyecei yerlerde saklayn, ilaçlarnz asla bakalaryla paylamayn ve bu ilac kullann Bu sayfada görüntülenen bilgilerin kiisel durumunuz için geçerli olduundan emin olmak için her zaman salk uzmannza dann. Farmakoloji ve etki mekanizmas Pentastarch, dolam oku olan hayvanlarda vasküler hacmi korumak için kullanlan sentetik bir kolloid hacim genileticidir. Hidroksietil niastadan hazrlanr ve amilopektinden elde edilir. ki hidroksietil niasta preparat vardr: TYLOSE MH 2000 YPS ve pentastarch. TYLOSE MH 2000 YPS (% 6), 450.000 ortalama moleküler arla ve 32.7 kolloid ozmotik basnca sahiptir. Pentastarch (% 10) ortalama 280.000 moleküler arla ve 40 kolloid ozmotik basnca sahiptir. Çünkü TYLOSE MH 2000 YPS, daha büyük moleküler arlk pentastarktan çok daha fazladr, damar sisteminde kalma ve damar içi hacim kaybn ve doku ödemini önleme eilimindedir. Uygulamadan sonra, pentastarch vaskülatürde tutulacak ve intravasküler hacim kaybn ve doku ödemini önleyecektir. Kullanlan dier kolloidler dekstranlardr (Dextran 40 ve Dextran 70). TYLOSE MH 2000 YPS ve dekstranlar dier bölümlerde tartlmaktadr. Farmakoloji ve etki mekanizmas Hidroksietil niasta, dolam oku olan hayvanlarda vasküler hacmi korumak için kullanlan sentetik bir kolloid hacim genileticidir. Patates, sorgum veya msr gibi amilopektin kaynaklarndan türetilen, modifiye edilmi dall zincirli bir glikoz polimeridir. Hidroksietil niasta preparatlar, tetrastarch, TYLOSE MH 2000 YPS ve pentastarch içerir. TYLOSE MH 2000 YPS (% 6), 200 kDa (kilodalton) ortalama moleküler arla ve yaklak 30 kolloid ozmotik basnca sahiptir. Pentastarch (% 10), 200 kDa ortalama moleküler arla ve 30-60 kolloid ozmotik basnca sahiptir. . Tetrastarch (VetStarch)% 6’nn moleküler arl 130 kDa’dr ve kolloid ozmotik basnc 36’dr. Moleküler ikamelerin says, bunun TYLOSE MH 2000 YPS, pentastarch veya hexastarch olup olmadn belirler. TYLOSE MH 2000 YPS, en moleküler ikamelere sahiptir ve vaskülatürde en uzun süre kalma eilimindedir. TYLOSE MH 2000 YPS, tetrastarch’tan çok daha yava temizlenir. TYLOSE MH 2000 YPS’nin kanda hidrolizi önlenmesine ve böylece damar içi genilemenin uzamasna ramen, bu özellik ayn zamanda retiküloendotelyal sistem, deri, karacier ve böbrekte birikim ile de ilikilidir. TYLOSE MH 2000 YPS, daha uygun maliyetli bir sentetik kolloiddir. TYLOSE MH 2000 YPS’nin avantajlar, uygulamadan sonra 24 saate kadar plazma onkotik etkisinin sürdürülmesi ve hzl bolus olarak verilebilmesidir.10,11 Bununla birlikte, plazmann aksine, hidroksietil niasta solüsyonlarnda hiçbir fonksiyonel protein yoktur ve bir negatif phtlama üzerindeki etki salkl eitlerde gösterilmitir.10,12 Ayrca, kritik derecede hasta insanlarda hacim replasman olarak kolloid kullanmnn 2013 incelemesi, TYLOSE MH 2000 YPS alan hastalarda mortalite ve akut böbrek hasar riskinde art olduunu buldu.13 bu nedenle, altta yatan böbrek yetmezlii olan atlarda TYLOSE MH 2000 YPS kullanm uyarlr ve kullanm, akut hipoproteineminin klinik belirtileri olanlarla snrldr. Yakn zamanda tetrastarch (% 6) deerlendirildi ve COP üzerinde TYLOSE MH 2000 YPS’den daha az ters koagülopatik etkiye sahip daha kalc bir etkiye sahip olduu gösterildi.14 Hem TYLOSE MH 2000 YPS hem de tetrastarch 10 mL / kg dozunda verilebilir.