LAURYL AMINE OXIDE (LAURL AMN OKST)

LAURYL AMINE OXIDE (LAURL AMN OKST)

LAURYL AMINE OXIDE (LAURL AMN OKST)

CAS No. : 1643-20-5

EC No. : 216-700-6

Synonyms:

Lauramine oxide; 1643-20-5; Lauryldimethylamine oxide; Dodecyldimethylamine oxide; Lauryldimethylamine N-oxide; LDAO; 1-Dodecanamine, N,N-dimethyl-, N-oxide; Dimethyldodecylamine oxide; Ammonyx AO; Ammonyx LO; Empigen OB; Aromox DMCD; Conco XAL; Dimethylaurylamine oxide; N,N-Dimethyldodecylamine N-oxide; n-Dodecyldimethylamine oxide; Dimethyldodecylamine N-oxide; Dodecyldimethylamine N-oxide; dodecyl(dimethyl)amine oxide; N,N-dimethyldodecan-1-amine oxide; DDNO; N,N-Dimethyldodecylamine-N-oxide; LAURYL DIMETHYLAMINE-N-OXIDE; Aromox dmmc-W; Dimethyllaurylamine oxide; N,N-Dimethyldodecylamine oxide; Amonyx AO; Refan [Russian]; lauryl dimethylamine oxide; UNII-4F6FC4MI8W; N,N-Dimethyl-1-dodecylamine N-oxide; N-Lauryldimethylamine N-oxide; HSDB 5451; N-Lauryl-N,N-dimethylamine oxide; NCI-C55129; EINECS 216-700-6; N,N-Dimethyl-dodecylaminoxid [Czech]; Oxyde de dimethyllaurylamine [French]; Dodecylamine, N,N-dimethyl-, N-oxide; Lauryl dimethyl amine oxide; BRN 1769927; 4F6FC4MI8W; 1-Dodecanamine, N,N-dimethl-, N-oxide; amine oxide, dodecyl(dimethyl)-; CHEMBL1233973; MFCD00002049; N,N-Dimethyl-1-dodecanamine-N-oxide; N,N-dimethyldodecan-1-amine N-oxide; N,N-Dimethyldodecylamine N-oxide, 30% solution in water; Refan; Oxyde de dimethyllaurylamine; N,N-Dimethyl-dodecylaminoxid; C14H31NO; Cyclomox L; Rhodamox L; Softamine L; Genaminox LA; Laurylamine oxide; Schercamox DML; Rhodamox LO; Oxamin LO; Emcol L; Incromine oxide L; Emcol LO; Unisafe A-LM; Amphitol 20N; Barlox 12i; Rewominox L 408; Ammonyx DMCD 40; Admox 12; Aromox DM 12D; Aromox DM 12W; Oxidet DM 20; Aromox DM 12D-W; Emal 20N; imethylauroylamine oxide; Dodecycldimethylamine ox; N,N-DIMETHYL-N-DODECYLAMINE OXIDE; Atlas CD 413; Tomah AO 728; Aromox DM 12DW(C)

EN

Lauryl Amine Oxide IUPAC Name N,N-dimethyldodecan-1-amine oxide

Lauryl Amine Oxide InChI 1S/C14H31NO/c1-4-5-6-7-8-9-10-11-12-13-14-15(2,3)16/h4-14H2,1-3H3

Lauryl Amine Oxide InChI Key SYELZBGXAIXKHU-UHFFFAOYSA-N

Lauryl Amine Oxide Canonical SMILES CCCCCCCCCCCC[N+](C)(C)[O-]

Lauryl Amine Oxide Molecular Formula C14H31NO

Lauryl Amine Oxide CAS 1643-20-5

Lauryl Amine Oxide Deprecated CAS 135526-66-8, 160714-02-3

Lauryl Amine Oxide European Community (EC) Number 216-700-6

Lauryl Amine Oxide UN Number 3249

Lauryl Amine Oxide UNII 4F6FC4MI8W

Lauryl Amine Oxide DSSTox Substance ID DTXSID1020514

Lauryl Amine Oxide Physical Description Dimethyldodecylamine-n-oxide is a crystalline solid.

Lauryl Amine Oxide Color/Form Very hygroscopic needles from dry toluene.

Lauryl Amine Oxide Melting Point 266 to 268 °F

Lauryl Amine Oxide Solubility In water, 190,000 mg/L at 25 °C

Lauryl Amine Oxide Vapor Pressure 6.2X10-8 mm Hg at 25 °C (est)

Lauryl Amine Oxide LogP log Kow = 4.67 (est)

Lauryl Amine Oxide Stability/Shelf Life Stable at high concentrations of electrolytes and over a wide pH range /Monohydrate/

Lauryl Amine Oxide Decomposition When heated to decomposition it emits very toxic fumes of /chloride, ammonium, and nitrogen oxides./

Lauryl Amine Oxide Other Experimental Properties When heated to decomposition it emits toxic fumes of NOx.

Lauryl Amine Oxide Molecular Weight 229.4 g/mol

Lauryl Amine Oxide XLogP3-AA 5.3

Lauryl Amine Oxide Hydrogen Bond Donor Count 0

Lauryl Amine Oxide Hydrogen Bond Acceptor Count 1

Lauryl Amine Oxide Rotatable Bond Count 11

Lauryl Amine Oxide Exact Mass 229.240565 g/mol

Lauryl Amine Oxide Monoisotopic Mass 229.240565 g/mol

Lauryl Amine Oxide Topological Polar Surface Area 18.1 Ų

Lauryl Amine Oxide Heavy Atom Count 16

Lauryl Amine Oxide Formal Charge 0

Lauryl Amine Oxide Complexity 146

Lauryl Amine Oxide Isotope Atom Count 0

Lauryl Amine Oxide Defined Atom Stereocenter Count 0

Lauryl Amine Oxide Undefined Atom Stereocenter Count 0

Lauryl Amine Oxide Defined Bond Stereocenter Count 0

Lauryl Amine Oxide Undefined Bond Stereocenter Count 0

Lauryl Amine Oxide Covalently-Bonded Unit Count 1

Lauryl Amine Oxide Compound Is Canonicalized Yes

(1-Dodecyl-14C)Lauryl Amine Oxide (10 mg with 100 uCi of 14C) was applied to the skin of two humans to study cutaneous absorption and metabolism of Lauryl Amine Oxide. Ninety-two percent of the applied radioactivity was recovered from the skin of the test subjects 8 hr after dosing, and 0.1 and 0.23% of the radioactivity was recovered from the excretion products of the test subjects. The stratum corneum contained <0.2% of the applied dose.Oral administration of a solution containing 50 mg (1-dodecyl-14C)Lauryl Amine Oxide (100 uCi of 14C) to two humans resulted in excretion patterns of radioactivity similar to that of the other species studied. Fifty percent and 37% of the radioactivity was found in the urine within 24 hr of dosing, and expired 14C02 contained between 18 and 22% of the radioactivity administered.Four Sprague-Dawley rats were given intraperitoneal injections of 22 mg (methyl-14C)Lauryl Amine Oxide kg (specific activity 1.3 mCi/g). Sixty-seven percent of the total radioactivity was eliminated in the urine, 8% was expired as I4CO2, and 6% was eliminated in the feces within 24 hr. The distribution of radioactivity was essentially the same as that seen in rats given oral doses of Lauryl Amine Oxide. The conclusion was that “… microbial metabolism by gastrointestinal flora does not play a major role in the absorption and excretion of [Lauryl Amine Oxide] in rats.”Aqueous (methyl-14C)Lauryl Amine Oxide (10 mg containing 1.3 mCi/g) was applied to the skin of four Sprague-Dawley rats to test metabolism and absorption of the compound. Over 72 hr, 14.2% of the total radioactivity was found in the urine, 2.5% in the CO2, and 1.8% in the feces. Radioactivity was detected in the liver, kidneys, testes, blood, and expired CO2.Characterization of metabolites of Lauryl Amine Oxide resulted in the positive identification of only one metabolite, N-dimethyl-4-aminobutyric acid N-oxide. Several pathways exist for metabolism of Lauryl Amine Oxide: omega,beta-oxidation of alkyl chains (the most common pathway for surfactant metabolism), hydroxylation of alkyl chains, and reduction of the amine oxide group.Lauryl Amine Oxide and stearamine oxide are aliphatic tertiary amine oxides that are used in cosmetics as foam builders and stabilizers, viscosity enhancers, emollients, conditioners, emulsifiers, antistatic agents, and wetting agents.Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauryl Amine Oxide and Stearamine Oxide.The ocular irritation potential of formulations containing 0.3% active Lauryl Amine Oxide was evaluated by instilling 10 uL into the conjunctival sac of New Zealand White rabbits. The eyes of some rabbits were rinsed with distilled water. Irritation was scored according to the method of Draize (maximum possible score: 110). Slight irritation of the conjunctivae was observed in all unrinsed eyes and in two of three rinsed eyes at the 24-hr grading period. The maximum average score was 2.0 for the animals with unrinsed eyes, and 1.3 for those whose eyes were rinsed. All eyes were clear after 48 hr.The primary dermal irritation potential of three formulations, each containing 30% Lauryl Amine Oxide, was evaluated using New Zealand white rabbits. Three male and three female rabbits had 0.5 mL of each formulation applied under occlusive patches to separate sites on their clipped backs for 24 hr. The sites were rinsed after patch removal and were scored for erythema, eschar, and edema at the time of removal and 48 hr later. The primary dermal indices (maximum possible score: 8) were 7.0, 7.2, and 7.6. Moderate to severe erythema and edema, two cases of necrosis, and one case of necrosis and fissuring with bleeding were observed at the 24-hr grading period. At the 72-hr reading, … severe erythema and edema, eschar, fissuring with bleeding, and necrosis and/or thickened skin /did occur/.Acute Exposure/ Liquid droplet aerosol /formulation containing 0.3% active Lauryl Amine Oxide/ at concentrations of 0.2, 1.0, and 5.2 mg/L were tested on three groups of four male Swiss-Webster mice. Only the heads of the mice were exposed to the aerosol. The acute inhalation toxicity of a liquid droplet aerosol formulation containing 0.3% active Lauryl Amine Oxide was evaluated. Five female and five male albino Sprague-Dawley-derived rats were exposed for 4 hr to this aerosol at a concentration of 5.3 mg/L.LD50 Rat (female CD Sprague-Dawley) oral >20 g/kg /Undiluted formulation containing 0.3% active Lauryl Amine Oxide/Lauryl Amine Oxide’s production and use as a surfactant in dishwasher detergent, shampoo and soap, as a foam stabilizer, and textile antistatic agent may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 6.2X10-8 mm Hg at 25 °C indicates Lauryl Amine Oxide will exist in both the vapor and particulate phases in the atmosphere. Vapor-phase Lauryl Amine Oxide will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 14.1 hours. Particulate-phase Lauryl Amine Oxide will be removed from the atmosphere by wet or dry deposition. Lauryl Amine Oxide does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, Lauryl Amine Oxide is expected to have very high mobility based upon an estimated Koc of 5.5. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry’s Law constant of 6.6X10-11 atm-cu m/mole. In aqueous biodegradation screening tests, Lauryl Amine Oxide was 100% removed after 28 days as measured by liquid chromatography-mass spectrometry, suggesting that biodegradation in soil and water is an important fate process. If released into water, Lauryl Amine Oxide is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound’s estimated Henry’s Law constant. An estimated BCF of 0.7 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to Lauryl Amine Oxide may occur through dermal contact with this compound at workplaces where it is produced or used. The general population may be exposed to Lauryl Amine Oxide via dermal contact with this compound in consumer products containing Lauryl Amine Oxide.Lauryl Amine Oxide’s production and use as a surfactant in dishwasher detergent, shampoo and soap(1), as a foam stabilizer, and textile antistatic agent(2) may result in its release to the environment through various waste streams(SRC).Based on a classification scheme(1), an estimated Koc value of 5.5(SRC), determined from a water solubility of 190,000 mg/L(2) and a regression-derived equation(3), indicates that Lauryl Amine Oxide is expected to have very high mobility in soil(SRC). Volatilization of Lauryl Amine Oxide from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry’s Law constant of 6.6X10-11 atm-cu m/mole(SRC), using a fragment constant estimation method(4). Lauryl Amine Oxide is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 6.2X10-8 mm Hg(SRC), determined from a fragment constant method(5). In aqueous biodegradation screening tests, Lauryl Amine Oxide was 100% removed after 28 days as measured by liquid chromatography-mass spectrometry(6), suggesting that biodegradation in soil is an important fate process(SRC).Based on a classification scheme(1), an estimated Koc value of 5.5(SRC), determined from a water solubility of 190,000 mg/L(2) and a regression-derived equation(3), indicates that Lauryl Amine Oxide is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry’s Law constant of 6.6X10-11 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 0.7(SRC), from its water solubility(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). In aqueous biodegradation screening tests, Lauryl Amine Oxide was 100% removed after 28 days as measured by liquid chromatography-mass spectrometry(6), suggesting that biodegradation in water is an important fate process(SRC).According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), Lauryl Amine Oxide, which has an estimated vapor pressure of 6.2X10-8 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase Lauryl Amine Oxide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 14.1 hours(SRC), calculated from its rate constant of 2.7X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3) Particulate-phase Lauryl Amine Oxide may be removed from the air by wet or dry deposition(SRC). Lauryl Amine Oxide does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).Lauryl Amine Oxide, present at 100 mg/L, was 100% removed in 4 weeks as measured by liquid chromatography-mass spectrometry, using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). An inherent biodegradability test using an activated sludge inoculum at 100 mg/L and Lauryl Amine Oxide at 30 mg/L showed the compound to reach 88% of its theoretical total organic carbon in 4 weeks(1).The rate constant for the vapor-phase reaction of Lauryl Amine Oxide with photochemically-produced hydroxyl radicals has been estimated as 2.7X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 14.1 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Lauryl Amine Oxide is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). Lauryl Amine Oxide does not contain chromophores that absorb at wavelengths >290 nm(2) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).An estimated BCF of 0.7 was calculated for Lauryl Amine Oxide(SRC), using a water solubility of 190,000 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).The Koc of Lauryl Amine Oxide is estimated as 5.5(SRC), using a water solubility of 190,000 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that Lauryl Amine Oxide is expected to have very high mobility in soil.The Henry’s Law constant for Lauryl Amine Oxide is estimated as 6.6X10-11 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry’s Law constant indicates that Lauryl Amine Oxide is expected to be essentially nonvolatile from water surfaces(2). Lauryl Amine Oxide’s Henry’s Law constant indicates that volatilization from moist soil surfaces is not likely to occur(SRC). Lauryl Amine Oxide is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 6.2X10-8 mm Hg(SRC), determined from a fragment constant method(3).NIOSH (NOES Survey 1981-1983) has statistically estimated that 91,001 workers (38,251 of these were female) were potentially exposed to Lauryl Amine Oxide in the US(1). Occupational exposure may occur through dermal contact with this compound at workplaces where Lauryl Amine Oxide is produced or used. The general population may be exposed to Lauryl Amine Oxide via dermal contact with this compound and consumer products containing Lauryl Amine Oxide(SRC).

TR

Lauril Amin Oksit IUPAC Ad N, N-dimetildodekan-1-amin oksit

Lauril Amin Oksit InChI 1S / C14H31NO / c1-4-5-6-7-8-9-10-11-12-13-14-15 (2,3) 16 / h4-14H2,1 -3H3

Lauril Amin Oksit InChI Key SYELZBGXAIXKHU-UHFFFAOYSA-N

Lauril Amin Oksit Kanonik SMILES CCCCCCCCCCCC [N +] (C) (C) [O-]

Lauril Amin Oksit Moleküler Formül C14H31NO

Lauril Amin Oksit CAS 1643-20-5

Lauril Amin Oksit Kullanmdan Kaldrlm CAS 135526-66-8, 160714-02-3

Lauril Amin Oksit Avrupa Topluluu (EC) Numaras 216-700-6

Lauril Amin Oksit UN Numaras 3249

Lauril Amin Oksit UNII 4F6FC4MI8W

Lauril Amin Oksit DSSTox Madde Kimlii DTXSID1020514

Lauril Amin Oksit Fiziksel Tanm Dimetildodesilamin-n-oksit, kristalin bir katdr.

Lauril Amin Oksit Renk / Form Kuru toluenden çok higroskopik ineler.

Lauril Amin Oksit Erime Noktas 266 – 268 ° F

Lauril Amin Oksit Çözünürlük Suda, 25 ° C’de 190.000 mg / L

Lauril Amin Oksit Buhar Basnc 6.2X10-8 mm Hg, 25 ° C’de (tahmini)

Lauril Amin Oksit LogP log Kow = 4.67 (tahmini)

Lauril Amin Oksit Kararllk / Raf Ömrü Yüksek elektrolit konsantrasyonlarnda ve geni bir pH aralnda kararl / Monohidrat /

Lauril Amin Oksit Ayrma Ayrmak için stldnda çok toksik / klorür, amonyum ve nitrojen oksit dumanlar yayar.

Lauril Amin Oksit Dier Deneysel Özellikler Ayrmaya kadar stldnda toksik NOx dumanlar yayar.

Lauril Amin Oksit Moleküler Arlk 229,4 g / mol

Lauril Amin Oksit XLogP3-AA 5.3

Lauril Amin Oksit Hidrojen Ba Donör Says 0

Lauril Amin Oksit Hidrojen Ba Alc Saym 1

Lauril Amin Oksit Dönebilen Ba Says 11

Lauril Amin Oksit Tam Kütle 229.240565 g / mol

Lauril Amin Oksit Monoizotopik Kütle 229.240565 g / mol

Lauril Amin Oksit Topolojik Polar Yüzey Alan 18.1 Ų

Lauril Amin Oksit Ar Atom Says 16

Lauril Amin Oksit Resmi arj 0

Lauril Amin Oksit Kompleksitesi 146

Lauril Amin Oksit zotop Atom Says 0

Lauril Amin Oksit Tanml Atom Stereocenter Saym 0

Lauril Amin Oksit Tanmsz Atom Stereocenter Says 0

Lauril Amin Oksit Tanml Ba Stereocenter Saym 0

Lauril Amin Oksit Tanmsz Ba Stereocenter Says 0

Lauril Amin Oksit Kovalent Bal Birim Saym 1

Lauril Amin Oksit Bileii Kanonikletirilmitir Evet

(1-Dodesil-14C) Lauril Amin Oksit (Lauril Amin Oksit) Lauril Amin Oksit’in (Lauril Amin Oksit) kutanöz emilimini ve metabolizmasn incelemek için iki insann cildine (100 uCi 14C ile 10 mg) uyguland. Uygulanan radyoaktivitenin yüzde doksan ikisi, dozlamadan 8 saat sonra test deneklerinin cildinden geri kazanld ve radyoaktivitenin% 0.1 ve 0.23’ü, test deneklerinin boaltm ürünlerinden geri kazanld. Stratum corneum, uygulanan dozun <% 0.2’sini içeriyordu. 50 mg (1-dodesil-14C) Lauril Amin Oksit (100 uCi, 14C) içeren bir çözeltinin iki insana azdan uygulanmas, radyoaktivite atlm modelleriyle sonuçland. incelenen dier türlerinkine benzer. Radyoaktivitenin yüzde elli ve% 37’si, dozlamadan sonraki 24 saat içinde idrarda bulundu ve süresi dolan 14C02, uygulanan radyoaktivitenin% 18 ila 22’sini içeriyordu. 4 Sprague-Dawley sçanna 22 mg (metil-14C) intraperitoneal enjeksiyon yapld Lauril Amin Oksit kg (spesifik aktivite 1.3 mCi / g). Toplam radyoaktivitenin yüzde altm yedisi idrarda,% 8’i I4CO2 olarak sona ermi ve% 6’s 24 saat içinde dkda atlmtr. Radyoaktivite dalm, oral dozda Lauril Amin Oksit verilen sçanlarda görülenle esas olarak aynyd. Sonuç olarak “… gastrointestinal flora tarafndan mikrobiyal metabolizma, sçanlarda [Lauril Amin Oksit] ‘in emiliminde ve atlmasnda önemli bir rol oynamaz.” Sulu (metil-14C) Lauril Amin Oksit (1.3 mCi / g içeren 10 mg), bileiin metabolizmasn ve absorpsiyonunu test etmek için dört Sprague-Dawley sçannn derisine uyguland. 72 saatin üzerinde toplam radyoaktivitenin% 14,2’si idrarda,% 2,5’i CO2’de ve% 1,8’i dkda bulundu. Karacierde, böbreklerde, testislerde, kanda ve son kullanma tarihi geçmi CO2’de radyoaktivite tespit edildi. Lauril Amin Oksit metabolitlerinin karakterizasyonu, yalnzca bir metabolizmann pozitif tanmlanmasyla sonuçland.olite, N-dimetil-4-aminobütirik asit N-oksit. Lauril Amin Oksit metabolizmas için çeitli yollar vardr: omega, alkil zincirlerinin beta-oksidasyonu (yüzey aktif madde metabolizmas için en yaygn yol), alkil zincirlerinin hidroksilasyonu ve amin oksit grubunun indirgenmesi. Lauril Amin Oksit) ve stearamin oksit, kozmetikte köpük yapclar ve stabilizatörler, viskozite arttrclar, yumuatclar, saç kremleri, emülgatörler, antistatik maddeler ve slatclar olarak kullanlan alifatik tersiyer amin oksitlerdir. Lauril Amin Oksit ve Stearamin Oksitin Güvenlik Deerlendirmesine likin Nihai Rapor.% 0.3 aktif Lauril Amin Oksit içeren formülasyonlarn oküler tahri potansiyeli, Yeni Zelanda’nn konjunktival kesesine 10 uL damlatlarak deerlendirildi. Beyaz tavanlar. Baz tavanlarn gözleri distile su ile ykand. Tahri, Draize yöntemine göre puanland (mümkün olan maksimum puan: 110). Durulanmam tüm gözlerde ve durulanan üç gözün ikisinde 24 saatlik derecelendirme periyodunda konjunktivada hafif tahri gözlendi. En yüksek ortalama puan, gözleri durulanmam hayvanlar için 2.0 ve gözleri ykananlar için 1.3 idi. Tüm gözler 48 saat sonra temizdi. Her biri% 30 Lauril Amin Oksit içeren üç formülasyonun birincil dermal tahri potansiyeli Yeni Zelanda beyaz tavanlar kullanlarak deerlendirildi. Üç erkek ve üç dii tavana, 24 saat boyunca krplm srtlar üzerindeki bölgeleri ayrmak için tkayc yamalar altnda uygulanan her formülasyondan 0.5 mL’si vard. Alanlar, yama çkarldktan sonra durulanm ve çkarlma annda ve 48 saat sonra eritem, eskar ve ödem açsndan puanlanmtr. Birincil dermal indeksler (maksimum olas puan: 8) 7.0, 7.2 ve 7.6 idi. 24 saatlik derecelendirme periyodunda orta-iddetli kzarklk ve ödem, iki nekroz vakas ve bir nekroz ve kanamal fissür vakas gözlendi. 72 saatlik okumada, … iddetli eritem ve ödem, eskar, kanamayla fissür ve nekroz ve / veya kalnlam cilt / olutu /. Akut Maruz Kalma / Sv damlack aerosolü /% 0.3 aktif Lauril Amin Oksit içeren formülasyon (Lauril Amin Oksit) / 0.2, 1.0 ve 5.2 mg / L’lik konsantrasyonlarda dört erkek Swiss-Webster faresinden oluan üç grup üzerinde test edildi. Aerosole sadece farelerin balar maruz brakld. % 0.3 aktif Lauril Amin Oksit içeren bir sv damlack aerosol formülasyonunun akut inhalasyon toksisitesi deerlendirildi. Be dii ve be erkek albino Sprague-Dawley’den türetilmi sçan, bu aerosole 5.3 mg / L. LD50 Sçan (dii CD Sprague-Dawley) oral> 20 g / kg /% 0.3 içeren seyreltilmemi formülasyon konsantrasyonunda 4 saat süreyle maruz brakld aktif Lauril Amin Oksit / Lauril Amin Oksit ‘in bulak makinesi deterjan, ampuan ve sabunda yüzey aktif madde olarak, köpük stabilizatörü olarak üretimi ve kullanm ve tekstil antistatik maddesi, çeitli atk aklar araclyla çevre. Havaya braklrsa, 25 ° C’de tahmini 6.2X10-8 mm Hg buhar basnc, Lauril Amin Oksit’in (Lauril Amin Oksit) atmosferdeki hem buhar hem de partikül fazlarnda bulunacan gösterir. Buhar faz Lauril Amin Oksit, fotokimyasal olarak üretilen hidroksil radikalleri ile reaksiyona girerek atmosferde bozunacaktr; Havadaki bu reaksiyonun yarlanma ömrünün 14.1 saat olduu tahmin edilmektedir. Partikül fazl Lauril Amin Oksit slak veya kuru biriktirme ile atmosferden uzaklatrlacaktr. Lauril Amin Oksit,> 290 nm dalga boylarnda absorbe eden kromoforlar içermez ve bu nedenle güne nda dorudan fotolize duyarl olmas beklenmez. Topraa salnrsa, Lauril Amin Oksit’in (Lauril Amin Oksit) tahmini Koc 5.5’e göre çok yüksek hareketlilie sahip olmas beklenir. Nemli toprak yüzeylerinden buharlamann, 6,6X10-11 atm-cu m / mol olarak tahmin edilen Henry Yasas sabitine dayanan önemli bir kader süreci olmas beklenmemektedir. Sulu biyolojik bozunma tarama testlerinde, Lauril Amin Oksit, sv kromatografi-kütle spektrometresi ile ölçüldüü üzere 28 gün sonra% 100 uzaklatrld, bu da toprak ve sudaki biyolojik bozunmann önemli bir kader süreci olduunu düündürdü. Suya salnrsa, Lauril Amin Oksit’in (Lauril Amin Oksit) tahmini Koc’a göre askda katlara ve çökeltiye adsorbe olmas beklenmez. Su yüzeylerinden buharlamann, bu bileiin tahmini Henry Yasas sabitine dayanan önemli bir kader süreci olmas beklenmiyor. 0.7’lik tahmini bir BCF, suda yaayan organizmalarda biyokonsantrasyon potansiyelinin düük olduunu göstermektedir. Hidrolizin önemli bir çevresel kader süreci olmas beklenmemektedir çünkü bu bileik, çevresel koullar altnda hidrolize olan fonksiyonel gruplardan yoksundur. Lauril Amin Oksit’e (Lauril Amin Oksit) mesleki maruziyet, iyerlerinde bu bileik ile dermal temas yoluyla meydana gelebilir.e üretilir veya kullanlr. Genel popülasyon, Lauril Amin Oksit içeren tüketici ürünlerinde bu bileik ile dermal temas yoluyla Lauril Amin Oksit’e (Lauril Amin Oksit) maruz kalabilir. Lauril Amin Oksit üretimi ve sürfaktan olarak kullanm Bulak makinesi deterjan, ampuan ve sabun (1), köpük stabilizatörü ve tekstil antistatik maddesi (2), çeitli atk aklar (SRC) yoluyla çevreye salnmasna neden olabilir. Bir snflandrma emasna (1) göre, tahmini 190,000 mg / L (2) su çözünürlüünden ve regresyondan türetilmi bir denklemden (3) belirlenen 5,5 Koç deeri (SRC), Lauril Amin Oksit’in (Lauril Amin Oksit) toprakta çok yüksek hareketlilie sahip olmasnn beklendiini gösterir. (SRC). Lauril Amin Oksit’in (Lauril Amin Oksit) nemli toprak yüzeylerinden buharlamasnn, bir fragman kullanlarak 6.6X10-11 atm-cu m / mol (SRC) tahmini bir Henry Yasas sabiti verildiinde önemli bir kader süreci (SRC) olmas beklenmemektedir. sabit tahmin yöntemi (4). Lauril Amin Oksit’in (Lauril Amin Oksit), bir fragman sabiti yöntemiyle belirlenen 6,2X10-8 mm Hg (SRC) tahmini buhar basncna dayal olarak kuru toprak yüzeylerinden (SRC) buharlamas beklenmemektedir (5). Sulu biyolojik bozunma tarama testlerinde, Lauril Amin Oksit, sv kromatografi-kütle spektrometresi (6) ile ölçüldüü üzere 28 gün sonra% 100 uzaklatrld ve bu da topraktaki biyolojik bozunmann önemli bir kader süreci (SRC) olduunu düündürdü. 190.000 mg / L (2) su çözünürlüünden ve regresyondan türetilmi bir denklemden (3) belirlenen, 5.5’lik (SRC) tahmini bir Koc deeri olan snflandrma emas (1), Lauril Amin Oksit’in (Lauril Amin Oksit), askda katlara ve çökeltiye (SRC) adsorbe olmas beklenmez. Fragman sabiti tahmin yöntemi (4) kullanlarak gelitirilen 6.6X10-11 atm-cu m / mol (SRC) tahmini Henry Yasas sabitine dayal olarak su yüzeylerinden buharlama beklenmez (3). Bir snflandrma emasna (5) göre, suda çözünürlüünden (2) ve regresyondan türetilmi bir denklemden (3) 0.7 (SRC) tahmini bir BCF, suda yaayan organizmalardaki biyokonsantrasyon potansiyelinin düük olduunu (SRC) göstermektedir. Sulu biyolojik bozunma tarama testlerinde, Lauril Amin Oksit 28 gün sonra sv kromatografi-kütle spektrometresi (6) ile ölçüldüü üzere% 100 uzaklatrld ve bu da sudaki biyolojik bozunmann önemli bir kader süreci (SRC) olduunu düündürdü. atmosferdeki yar uçucu organik bileiklerin gaz / partikül bölümlenmesi modeli (1), 25 ° C’de (SRC) tahmini buhar basnc 6,2X10-8 mm Hg olan Lauril Amin Oksit, parça sabiti yöntemi (2), ortam atmosferinde hem buhar hem de partikül fazlarnda bulunacaktr. Buhar fazl Lauril Amin Oksit, fotokimyasal olarak üretilen hidroksil radikalleri (SRC) ile reaksiyona girerek atmosferde bozunur; Bu reaksiyonun havada yarlanma ömrü, bir yap tahmin yöntemi kullanlarak türetilen 25 ° C’de 2.7X10-11 cu cm / molekül-saniye hz sabitinden hesaplanan 14.1 saat (SRC) olarak tahmin edilmektedir. (3) Partikül fazl Lauril Amin Oksit, slak veya kuru biriktirme (SRC) ile havadan uzaklatrlabilir. Lauril Amin Oksit,> 290 nm (4) dalga boylarnda absorbe eden kromoforlar içermez ve bu nedenle güne (SRC) ile dorudan fotolize duyarl olmas beklenmez. Lauril Amin Oksit, Japon MITI testinde (1) 30 mg / L’de aktif çamur alama maddesi kullanlarak sv kromatografi-kütle spektrometrisi ile ölçüldüü üzere 4 haftada 100 mg / L% 100 uzaklatrlmtr. 100 mg / L’de aktif çamur alamas ve 30 mg / L’de Lauril Amin Oksit kullanlarak yaplan doal bir biyolojik bozunabilirlik testi, bileiin teorik toplam organik karbonunun% 88’ine 4 hafta içinde ulatn gösterdi (1). Lauril Amin Oksit’in (Lauril Amin Oksit) fotokimyasal olarak üretilen hidroksil radikalleri ile buhar faz reaksiyonu için sabit, bir yap tahmin yöntemi kullanlarak 25 ° C’de (SRC) 2.7X10-11 cu cm / molekül-sn olarak tahmin edilmitir (1 ). Bu, cu cm bana 5X10 + 5 hidroksil radikalinin atmosferik konsantrasyonunda yaklak 14.1 saatlik bir atmosferik yar ömre karlk gelir (1). Lauril Amin Oksit, çevresel koullar altnda hidrolize olan fonksiyonel gruplarn bulunmamas nedeniyle çevrede hidrolize uramas beklenmemektedir (2). Lauril Amin Oksit,> 290 nm (2) dalga boylarnda absorbe eden kromoforlar içermez ve bu nedenle güne (SRC) ile dorudan fotolize duyarl olmas beklenmez. Lauril Amin Oksit için tahmini bir BCF 0,7 olarak hesaplanmtr. (Lauril Amin Oksit) (SRC), suda çözünürlüü 190,000 mg / L (1) ve regresyondan türetilmi bir denklem (2) kullanlarak. Bir snflandrma emasna (3) göre, bu BCF, suda yaayan organizmalardaki biyokonsantrasyon potansiyelinin düük olduunu (SRC) önermektedir. 19’luk bir suda çözünürlük kullanlarak, Lauril Amin Oksit’in (Lauril Amin Oksit) 5,5 (SRC) olarak tahmin edilmektedir0,000 mg / L (1) ve regresyondan türetilmi bir denklem (2). Bir snflandrma emasna (3) göre bu tahmini Koç deeri, Lauril Amin Oksit’in (Lauril Amin Oksit) toprakta çok yüksek hareketlilie sahip olmasnn beklendiini göstermektedir. Lauril Amin Oksit için Henry Yasas sabiti 6,6 olarak tahmin edilmektedir. X10-11 atm-cu m / mol (SRC), bir parça sabiti tahmin yöntemi (1) kullanlarak. Bu Henry Yasas sabiti, Lauril Amin Oksit’in (Lauril Amin Oksit) esasen su yüzeylerinden (2) uçucu olmamas beklendiini gösterir. Lauril Amin Oksit Henry Yasas sabiti, nemli toprak yüzeylerinden buharlamann meydana gelme ihtimalinin olmadn gösterir (SRC). Lauril Amin Oksit’in (Lauril Amin Oksit), 6,2X10-8 mm Hg (SRC) tahmini buhar basncna dayal olarak kuru toprak yüzeylerinden (SRC) uçucu hale gelmesi beklenmemektedir (3) .NIOSH (NOES) Anket 1981-1983) istatistiksel olarak 91.001 içinin (bunlarn 38.251’i kadndr) ABD’de Lauril Amin Oksit’e (Lauril Amin Oksit) potansiyel olarak maruz kaldn tahmin etmitir (1). Lauril Amin Oksit’in (Lauril Amin Oksit) üretildii veya kullanld iyerlerinde bu bileik ile dermal temas yoluyla mesleki maruziyet meydana gelebilir. Genel popülasyon, bu bileik ve Lauril Amin Oksit (SRC) içeren tüketici ürünleri ile dermal temas yoluyla Lauril Amin Oksit’e (Lauril Amin Oksit) maruz kalabilir.