DISODIUM PHOSPHATE (DSODYUM FOSFAT)

DISODIUM PHOSPHATE (DSODYUM FOSFAT)

DISODIUM PHOSPHATE (DSODYUM FOSFAT)

CAS No. : 7558-79-4

EC No. : 231-448-7

Synonyms:

7558-79-4; Disodium hydrogen phosphate; DISODIUM PHOSPHATE; Disodium hydrogenorthophosphate; Sodium phosphate dibasic; Dibasic sodium phosphate; Acetest; Soda phosphate; Sodium phosphate, dibasic; Phosphoric acid, disodium salt; Disodium orthophosphate; Disodium acid phosphate; Sodium hydrogenphosphate; disodium hydrogenphosphate; Sodium hydrogen phosphate; Phosphate of soda; Exsiccated sodium phosphate; Disodium acid orthophosphate; sec-Sodium phosphate; Sodium monohydrogen phosphate; Caswell No. 778; Disodium hydrophosphate; Disodium monohydrogen phosphate; FEMA No. 2398; Disodium phosphoric acid; FEMA Number 2398; Natriumphosphat [German]; secondary Sodium phosphate; Sodium phosphate (NaHPO4); Sodium phosphate, exsiccated; UNII-22ADO53M6F; Disodium hydrogen phosphate, anhydrous; Disodium phosphate, anhydrous; Sodium phosphate, dibasic (anhydrous); CCRIS 5931; HSDB 376; Sodium orthophosphate, secondary; Sodium acid phosphate, anhydrous; SODIUM PHOSPHATE, DIBASIC, ANHYDROUS; Na2HPO4; EINECS 231-448-7; DSP; Hydrogen disodium phosphate; Phosphoric acid, sodium salt (1:2); EPA Pesticide Chemical Code 076403; Sodium monohydrogen phosphate (2:1:1); SODIUM PHOSPHATE, DIBASIC ANHYDROUS; 22ADO53M6F; Disodium hydrogen orthophosphate; CHEBI:34683; Sodium Phosphate dibasic anhydrous; MFCD00003496; di-Sodium hydrogen phosphate anhydrous, USP grade; Monohydrogen Sodium Phosphate; Fleet enema; Potassium Phosphate Monobasic/Sodium Phosphate Dibasic; Sodium phosphate, dibasic, 98%, extra pure, anhydrous; Disodiumhydrogenorthophosphate; Sodium phosphate, dibasic, 99+%, for analysis, anhydrous; Sodium phosphate, dibasic, 99+%, ACS reagent, suitable for buffer solutions; Disodiumhydrogenphosphate; ACMC-20al4j; HNa2O4P; sodium hydrogen-phosphate; disodium hydrogen-phosphate; Buffer Salt, pH 6.87; Buffer Salt, pH 7.42; EC 231-448-7; Sorensen’s sodium phosphate; di-sodium hydrogen phosphate; phosphoric acid disodium salt; sodium hydrogen orthophosphate; KSC377C3J; Disodium hydrogen monophosphate; INS NO.339(II); DTXSID1026039; CTK2H7134; INS-339(II); KS-00000UOU; Dibasic sodium phosphate anhydrous; Sodium phosphate,dibasic,anhydrous; dibasic sodium phosphate, anhydrous; BCP13559; Sodium phosphate dibasic, ACS grade; Disodium Phosphate (Fragrance Grade); E-339(II); AKOS015902440; AKOS015950661; Disodium Phosphate (Industrial Grade); CCG-266159; DB14502; di-Sodium hydrogen phosphate, anhydrous; LS-1682; phosphoric acid, disodium salt, anhydrous; Sodium phosphate dibasic, biochemical grade; AK01050735; B7293; FT-0625321; Sodium phosphate dibasic, Trace metals grade; Y1397; C13558; Q418448; UNII-GR686LBA74 component BNIILDVGGAEEIG-UHFFFAOYSA-L; 231-448-7 [EINECS]; 7558-79-4 [RN]; anhydrousdibasicsodium phosphate; Dinatriumhydrogenphosphat [German] [ACD/IUPAC Name]; Disodium hydrogen phosphate [ACD/IUPAC Name]; Disodium hydrogenorthophosphate; disodium hydrogenphosphate; Disodium phosphate [Wiki]; Disodiumhydrogenorthophosphate; Hydrogénophosphate de disodium [French] [ACD/IUPAC Name]; MFCD00003496 [MDL number]; Na2HPO4 [Formula]; Phosphoric acid disodium salt; secondary Sodium phosphate; sodium hydrogen phosphate (2:1:1); Sodium hydrogenphosphate; Sodium monohydrogen phosphate; Sodium phosphate dibasic; Sodium Phosphate dibasic anhydrous; 10028-24-7 [RN]; 10039-32-4 [RN]; 148560-76-3 [RN]; Dibasic sodium phosphate; disodium acid orthophosphate; Disodium acid phosphate; Disodium hydrogen orthophosphate; di-sodium hydrogenphosphate; Disodium hydrophosphate; disodium monohydrogen phosphate; DISODIUM ORTHOPHOSPHATE; di-sodium phosphate; DISODIUM PHOSPHORIC ACID; DSP; phosphate disodium; Soda phosphate; Sodium hydrogen phosphate; Sodium orthophosphate, secondary; Sodium phosphate dibasic, ACS grade; Sodium Phosphate, Dibasic

EN

Disodium Phosphate (Disodyum Fosfat) IUPAC Name disodium;hydrogen phosphate

Disodium Phosphate InChI 1S/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-2

Disodium Phosphate InChI Key BNIILDVGGAEEIG-UHFFFAOYSA-L

Disodium Phosphate Canonical SMILES OP(=O)([O-])[O-].[Na+].[Na+]

Disodium Phosphate Molecular Formula HO4PNa2

Disodium Phosphate CAS 7558-79-4

Disodium Phosphate Related CAS 7632-05-5 (Parent)

Disodium Phosphate Deprecated CAS 148560-76-3, 1374442-71-3

Disodium Phosphate European Community (EC) Number 231-448-7

Disodium Phosphate ICSC Number 1129

Disodium Phosphate RTECS Number WC4500000

Disodium Phosphate UN Number 3082

Disodium Phosphate UNII 22ADO53M6F

Disodium Phosphate FEMA Number 2398

Disodium Phosphate DSSTox Substance ID DTXSID1026039

Disodium Phosphate Physical Description DryPowder; Liquid

Disodium Phosphate Color/Form olorless, translucent crystals or white powder.

Disodium Phosphate Odor NONE

Disodium Phosphate Taste Saline taste

Disodium Phosphate Solubility greater than or equal to 100 mg/mL at 68° F 

Disodium Phosphate Density 1.8 to 2.5 at 77 °F

Disodium Phosphate LogP -5.8

Disodium Phosphate Stability/Shelf Life On exposure to air, it absorbs 2-7 moles water depending on humidity and temperature.

Disodium Phosphate Decomposition ~250 °C

Disodium Phosphate pH Between 8,4 and 9,6 (1 % solution)

Disodium Phosphate Dissociation Constants pKa1 = 2.15; pKa2 = 6.83; pKa3 = 12.38 (phosphoric acid), all at 25 °C

Disodium Phosphate Molecular Weight 141.959 g/mol

Disodium Phosphate Hydrogen Bond Donor Count 1

Disodium Phosphate Hydrogen Bond Acceptor Count 4

Disodium Phosphate Rotatable Bond Count 0

Disodium Phosphate Exact Mass 141.940784 g/mol

Disodium Phosphate Monoisotopic Mass 141.940784 g/mol

Disodium Phosphate Topological Polar Surface Area 83.4 Ų

Disodium Phosphate Heavy Atom Count 7

Disodium Phosphate Formal Charge 0

Disodium Phosphate Complexity 46.5

Disodium Phosphate Isotope Atom Count 0

Disodium Phosphate Defined Atom Stereocenter Count 0

Disodium Phosphate Undefined Atom Stereocenter Count 0

Disodium Phosphate Defined Bond Stereocenter Count 0

Disodium Phosphate Undefined Bond Stereocenter Count 0

Disodium Phosphate Covalently-Bonded Unit Count 3

Disodium Phosphate Compound Is Canonicalized Yes

Disodium Phosphate, dibasic appears as a colorless to white crystalline solid. Soluble in water. The primary hazard is the threat to the environment. Immediate steps should be taken to limit spread to the environment. Used as a fertilizer, in pharmaceuticals, in food processing, and for many other uses.Disodium hydrogenphosphate is a Disodium Phosphate.Disodium Phosphate, dibasic appears as a colorless to white crystalline solid. Soluble in water. The primary hazard is the threat to the environment. Immediate steps should be taken to limit spread to the environment. Used as a fertilizer, in pharmaceuticals, in food processing, and for many other uses.Disodium Phosphate is a white, hygroscopic, odourless powder. Hydrated forms available include the dihydrate: a white crystalline, odourless solid; the heptahydrate: white, odourless, efflorescent crystals or granular powder; and the dodecahydrate: white, efflorescent, odourless powder or crystals.Disodium Phosphate Injection, USP, … is indicated as a source of phosphorus, for addition to large volume intravenous fluids, to prevent or correct hypophosphatemia in patients with restricted or no oral intake. It is also useful as an additive for preparing specific parenteral fluid formulas when the needs of the patient cannot be met by standard electrolyte or nutrient solutions.To determine whether phosphate supplementation, started soon after birth in adequate quantity, would prevent rickets in very low birth weight infants with prenatal deficiency of phosphate, 40 neonates were given an initial dose of 50 mg/day of phosphate administered as a mixture of 189 g of Disodium Phosphate dibasic (disodium hydrogen phosphate) and 82 g of Disodium Phosphate monobasic (sodium dihydrogen phosphate) made up to 2 liters with single strength chloroform water or placebo (single strength chloroform water). Supplementation was increased to 37.5 mg every 12 hr if the plasma phosphate concentration remained less than 1.5 mmol/L after one wk. Results showed that no infant receiving phosphate supplements had radiological evidence of rickets whereas bone changes were apparent in 42% of the control group. It was concluded that prenatal deficiency of phosphate, due to placental insufficiency, can be corrected by phosphate supplementation, thereby preventing rickets of prematurity.Sixty patients were randomly divided into three groups of 20 each. Each group was submitted to a bowel preparation with one of the following solutions: 10% manitol, sodium picosulfate or Disodium Phosphate. The parameters evaluated were: taste, tolerance, associated side effects and quality of cleansing. Postural blood pressure and pulse rate as well as serum sodium, potassium, calcium and phosphate were compared. … Disodium Phosphate and 10% manitol solutions provided superior results in terms of colon cleansing compared to sodium picosulfate solution.Disodium Phosphate inceases fecal water content to increase mobility through the large intestine.Disodium Phosphate (DSP), or sodium hydrogen phosphate, or sodium phosphate dibasic, is the inorganic compound with the formula Na2HPO4. It is one of several sodium phosphates. The salt is known in anhydrous form as well as forms with 2, 7, 8, and 12 hydrates. All are water-soluble white powders; the anhydrous salt being hygroscopic.Disodium Phosphate is the sodium salt derived from phosphate rock in the earth.In mouthwash Disodium Phosphate acts as a buffering agent that helps maintain the pH or acidity of the product. When Disodium Phosphate is combined with fluoride and phosphoric acid to form an acidulated phosphate fluoride  solution as outlined in the FDA’s Anticaries monograph, that solution promotes remineralization and helps prevent enamel dissolution.Disodium Phosphate is made by combining phosphoric acid, derived from phosphate rock, with soda ash. This material is then crystallized and purified for use in our products.For anticaries mouthwash products, with acidulated phosphate fluoride solution, Disodium Phosphate and phosphoric acid are required in conjunction with Sodium Fluoride per the Anticaries Drug Products for Over-the-Counter Human Use, Final Monograph.1 Tom’s offers both fluoride and fluoride free mouthwash options.Disodium Phosphate is Generally Recognized as Safe (GRAS) by the FDA to be used as a food substance for human consumption.Used as emulsifier and buffer in foods and pharmaceuticals, metal phosphatising/electroplating reagent, scale inhibitor (boiling water treatment), textile/leather auxiliary, sequestrant, mordant in dyeing, fireproofing agent, reagent and buffer in analytical chemistry, cathartic, and veterinary laxative; Also used for weighting silk and in pottery glazes/porcelain/enamels, tanning, and soldering/brazing (instead of borax); [HSDB] Used in fertilizers, galvanoplastics, and as a dietary supplement.A mild skin, eye, and respiratory tract irritant; [ICSC] Emergency treatment: “Inorganic phosphates”; Inorganic phosphates can cause diarrhea, hyperphosphatemia, and hypocalcemia after ingestion; An adult died after receiving four sodium phosphate enemas within 24 hours; he had electrolyte abnormalities and died from cardiac arrest; [HSDB] A mild eye irritant in rabbits.Disodium Phosphate (Na2HPO4) is a sodium salt of phosphoric acid. It is a white powder that is highly hygroscopic. It is used as an anti-caking additive in powder products.The objective of this study was to determine the safety and efficacy of 0.15 mmol/kg phosphorus (PHOS), administered intravenously as sodium or potassium phosphate over 120 minutes, in the treatment of adults suffering from severe hypophosphatemia. Severe hypophosphatemia was defined as a serum PHOS concentration of |LE/ 1.5 mg/dL. Exclusion criteria were renal impairment and hypercalcemia. Patient assessments included mental status, heart rate, and blood pressure. The timing of post-infusion serum PHOS sampling was at physician discretion. Six men and four women were enrolled in the study. During the study period, the only parenteral PHOS administered was the study dose. There were no patient adverse events associated with PHOS administration. One patient who received potassium phosphates had an elevated post-infusion serum potassium (5.2 mEq). Serum PHOS increased above the study criteria for severe hypophosphatemia in all ten patients, although nine patients received concomitant oral PHOS supplements. The dosing of intravenous sodium or potassium phosphate in the treatment of patients with severe hypophosphatemia is empiric. Historical evidence of toxicity has caused dosing recommendations to be low and slow. These data demonstrate the safety of a moderate PHOS dose when administered over two hours to adults, as measured by patient mental status, vital signs, and blood chemistry analysis.Phosphorus is present in plasma and other extracellular fluid, in cell membranes and intracellular fluid, as well as in collagen and bone tissues. Phosphorus in the extracellular fluid is primarily in inorganic form and plasma levels may vary somewhat with age. The ratio of disodium phosphate and monosodium phosphate in the extracellular fluid is 4 to 1 (80% to 20%) at the normal pH of 7.4. This buffer ratio varies with the pH, but owing to its relatively low concentration, it contributes little to the buffering capacity of the extracellular fluid.Sodium phosphate is thought to work by increasing the amount of solute present in the intestinal lumen thereby creating an osmotic gradient which draws water into the lumen.At the renal distal tubule, the secretion of hydrogen by the tubular cell in exchange for sodium in the tubular urine converts dibasic phosphate salts to monobasic phosphate salts. Therefore, large amounts of acid can be excreted without lowering the pH of the urine to a degree that would block hydrogen transport by a high concentration gradient between the tubular cell and luminal fluid. Sodium monophosphates are usually produced by neutralization of phosphoric acid with soda ash or caustic soda. The latter is predominantly used in Germany, while in the United States, the less expensive soda ash prevails. The basicity of sodium carbonate is insufficient for the formation of trisodium phosphate, so that caustic soda must be used in this step. The phosphates crystallize from the solutions as hydrates and are separated by centrifugation. Anhydrous salts are obtained by dehydration in rotary dryers or directly from the solutions by spray drying or in rotary kilns. Both thermal phosphoric acid and the cheaper wet phosphoric acid are used as starting materials. The very pure thermal phosphoric acid is generally used in the production of food-grade phosphates.Phosphorus is present in plasma and other extracellular fluid, in cell membranes and intracellular fluid, as well as in collagen and bone tissues. Phosphorus in the extracellular fluid is primarily in inorganic form and plasma levels may vary somewhat with age. The ratio of Disodium Phosphate and monosodium phosphate in the extracellular fluid is 4 to 1 (80% to 20%) at the normal pH of 7.4. This buffer ratio varies with the pH, but owing to its relatively low concentration, it contributes little to the buffering capacity of the extracellular fluid.The single largest use for Disodium Phosphate is as an emulsifying aid for pasteurized process cheese.Gelling strength of agar gel was significantly increased by addition of 0.12-0.3% Disodium Phosphate.Addition of Disodium Phosphate to clarified sugar cane juice at levels of 0.01-0.05% reduced hydrolysis of the sugars and thus reduced caramelization, which leads to dark-colored raw sugar.Residues of Disodium Phosphate are exempted from the requirement of a tolerance when used as a anticaking agent, conditioning agent in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.Residues of Disodium Phosphate are exempted from the requirement of a tolerance when used as a anticaking agent, conditioning agent in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.Disodium Phosphate used as a sequestrant in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice.Disodium Phosphate used as a sequestrant in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.Except for D-thyroxine, the hypocholesterolemic agents tested did not prevent the formation of cardiac lesions in rats on a thrombogenic diet, being treated with large doses of Disodium Phosphate.Disodium Phosphate increased the antirachitic activity of vitamin D3 in 3 week old rats.Disodium Phosphate given intracerebroventricularly (ICV) in rats elicited a syndrome characterized by behavioral and EEG activation, stereotypes, hyperresponsiveness, and analgesia.

TR

Disodyum Fosfat IUPAC Ad disodyum; hidrojen fosfat

Disodyum Fosfat InChI 1S / 2Na.H3O4P / c ;; 1-5 (2,3) 4 / h ;; (H3,1,2,3,4) / q2 * + 1; / p-2

Disodyum Fosfat InChI Key BNIILDVGGAEEIG-UHFFFAOYSA-L

Disodyum Fosfat Kanonik SMILES OP (= O) ([O -]) [O -]. [Na +]. [Na +]

Disodyum Fosfat Moleküler Formül HO4PNa2

Disodyum Fosfat CAS 7558-79-4

Disodyum Fosfat lgili CAS 7632-05-5 (Ana)

Disodyum Fosfat Kullanmdan Kaldrlm CAS 148560-76-3, 1374442-71-3

Disodyum Fosfat Avrupa Topluluu (EC) Say 231-448-7

Disodyum Fosfat ICSC Numaras 1129

Disodyum Fosfat RTECS Numaras WC4500000

Disodyum Fosfat UN Numaras 3082

Disodyum Fosfat UNII 22ADO53M6F

Disodyum Fosfat FEMA Numaras 2398

Disodyum Fosfat DSSTox Madde Kimlii DTXSID1026039

Disodyum Fosfat Fiziksel Tanmlama Kuru Toz; Sv

Disodyum Fosfat Renkli / Formsuz, yar saydam kristaller veya beyaz toz.

Disodyum Fosfat Koku YOK

Disodyum Fosfat Tat Saline tad

Disodyum Fosfat 68 ° F’de 100 mg / mL veya daha büyük çözünürlük

Disodyum Fosfat Younluk 1,8 – 2,5, 77 ° F

Disodyum Fosfat LogP -5.8

Disodyum Fosfat Kararllk / Raf Ömrü Havaya maruz kaldnda nem ve scakla bal olarak 2-7 mol suyu emer.

Disodyum Fosfat Ayrmas ~ 250 ° C

Disodyum Fosfat pH 8,4 ile 9,6 arasnda (% 1 çözelti)

Disodyum Fosfat Ayrma Sabitleri pKa1 = 2.15; pKa2 = 6,83; pKa3 = 12.38 (fosforik asit), tümü 25 ° C’de

Disodyum Fosfat Moleküler Arlk 141.959 g / mol

Disodyum Fosfat Hidrojen Ba Donör Says 1

Disodyum Fosfat Hidrojen Ba Alc Says 4

Disodyum Fosfat Dönebilen Ba Says 0

Disodyum Fosfat Tam Kütle 141.940784 g / mol

Disodyum Fosfat Monoizotopik Kütle 141.940784 g / mol

Disodyum Fosfat Topolojik Polar Yüzey Alan 83.4 Ų

Disodyum Fosfat Ar Atom Says 7

Disodyum Fosfat Resmi arj 0

Disodyum Fosfat Karmakl 46.5

Disodyum Fosfat zotop Atom Says 0

Disodyum Fosfat Tanml Atom Stereocenter Says 0

Disodyum Fosfat Tanmsz Atom Stereocenter Says 0

Disodyum Fosfat Tanml Bond Stereocenter Says 0

Disodyum Fosfat Tanmsz Ba Stereocenter Says 0

Disodyum Fosfat Kovalent Bal Birim Says 3

Disodyum Fosfat Bileii Kanonikalize Edilmitir Evet

Disodyum Fosfat, dibazik renksizden beyaza kristal bir kat olarak görünür. Suda çözünebilir. Birincil tehlike, çevreye yönelik tehdittir. Çevreye yaylmay snrlandrmak için acil admlar atlmaldr. Gübre olarak, ilaçlarda, gda ilemede ve dier birçok kullanmda kullanlan Disodyum Hidrojenfosfat, bir Disodyum Fosfattr (Disodyum Fosfat) .Disodyum Fosfat, dibazik renksiz ila beyaz kristalli bir kat olarak görünür. Suda çözünebilir. Birincil tehlike, çevreye yönelik tehdittir. Çevreye yaylmay snrlandrmak için acil admlar atlmaldr. Gübre olarak, ilaç yapmnda, gda ilemede ve daha birçok kullanmda kullanlan Disodyum Fosfat beyaz renkli, higroskopik, kokusuz bir tozdur. Mevcut hidratl formlar arasnda dihidrat: beyaz kristalli, kokusuz bir kat; heptahidrat: beyaz, kokusuz, çiçek açan kristaller veya granüler toz; ve dodekahidrat: beyaz, efloresan, kokusuz toz veya kristaller. Disodyum Fosfat Enjeksiyonu, USP … kstl veya oral alm yok. Ayrca, hastann ihtiyaçlar standart elektrolit veya besin solüsyonlar ile karlanamadnda spesifik parenteral sv formüllerinin hazrlanmasnda katk maddesi olarak faydaldr. Doumdan hemen sonra yeterli miktarda balayan fosfat desteinin çok düük doumlarda raitizmi önleyip önlemeyeceini belirlemek için doum öncesi fosfat eksiklii olan bebeklere, 40 yenidoana 189 g Disodyum Fosfat dibazik (disodyum hidrojen fosfat) ve 82 g Disodyum Fosfat (Disodyum) karm olarak uygulanan 50 mg / gün fosfat balangç ​​dozu verildi. Fosfat) monobazik (sodyum dihidrojen fosfat), 2 litreye kadar tek kuvvetli kloroform su veya plasebo (stek kuvvetli kloroform suyu). Plazma fosfat konsantrasyonu bir hafta sonra 1.5 mmol / L’nin altnda kaldysa, takviye her 12 saatte bir 37.5 mg’a yükseltildi. Sonuçlar, fosfat takviyesi alan hiçbir bebekte radyolojik raitizm kant bulunmadn, ancak kontrol grubunun% 42’sinde kemik deiikliklerinin belirgin olduunu gösterdi. Plasenta yetmezliine bal prenatal fosfat eksikliinin fosfat takviyesi ile düzeltilebilecei ve böylece prematüre raitizminin önlenebilecei sonucuna varld. 60 hasta rastgele 20’er kiilik üç gruba ayrld. Her grup aadaki solüsyonlardan biriyle barsak hazrlna tabi tutuldu:% 10 manitol, sodyum pikosülfat veya Disodyum Fosfat. Deerlendirilen parametreler unlard: tat, tolerans, ilikili yan etkiler ve temizleme kalitesi. Postüral kan basnc ve nabz hz ile serum sodyum, potasyum, kalsiyum ve fosfat karlatrld. … Disodyum Fosfat ve% 10 manitol çözeltileri, sodyum pikosülfat çözeltisine göre kolon temizlii açsndan üstün sonuçlar salamtr.Disodyum Fosfat, kaln barsakta hareketlilii artrmak için dk suyu içeriini arttrr.Disodyum Fosfat (DSP) veya sodyum hidrojen fosfat veya sodyum fosfat dibazik, Na2HPO4 formülüne sahip inorganik bileiktir. Birkaç sodyum fosfattan biridir. Tuz, susuz formda ve 2, 7, 8 ve 12 hidratl formlarda bilinir. Hepsi suda çözünür beyaz tozlardr; Susuz tuz, higroskopiktir.Disodyum Fosfat, yeryüzündeki fosfat kayasndan elde edilen sodyum tuzudur.Az ykamada Disodyum Fosfat, ürünün pH veya asitliini korumaya yardmc olan bir tamponlama maddesi görevi görür. Disodyum Fosfat, florür ve fosforik asit ile birletirilerek FDA’nn Antikarlar monografisinde belirtildii gibi asitlenmi bir fosfat florür çözeltisi oluturduunda, bu çözelti remineralizasyonu tevik eder ve mine çözünmesini önlemeye yardmc olur. soda külü ile fosfat kayasndan elde edilen asit. Bu malzeme daha sonra kristalize edilir ve ürünlerimizde kullanlmak üzere saflatrlr.Antikar gargara ürünlerinde, Asitlenmi fosfat florür çözeltili, Disodyum Fosfat ve fosforik asit, Over-the-Anticaries laç Ürünlerine göre Sodyum Florür ile birlikte gereklidir. Sayaç nsan Kullanm, Nihai Monograf.1 Tom’s hem florür hem de florür içermeyen gargara seçenekleri sunar.Disodyum Fosfat, FDA tarafndan insan tüketimi için gda maddesi olarak kullanlmak üzere Genel Olarak Güvenli (GRAS) Kabul Edilir. gdalarda ve eczaclkta tampon, metal fosfatlama / elektrokaplama reaktifi, kireç önleyici (kaynar su muamelesi), tekstil / deri yardmc maddesi, tecrit edici, boyamada mordan, yanmaz ajan, analitik kimyada reaktif ve tampon, katartik ve veteriner laksatifi; Ayrca ipein tartlmasnda ve seramik srlarnda / porselen / emayelerde, tabaklama ve lehimlemede / sert lehimlemede (boraks yerine) kullanlr; [HSDB] Gübrelerde, galvanoplastiklerde ve besin takviyesi olarak kullanlr. Hafif cilt, göz ve solunum yolunu tahri eder; [ICSC] Acil tedavi: “norganik fosfatlar”; norganik fosfatlar yutulduktan sonra ishale, hiperfosfatemiye ve hipokalsemiye neden olabilir; Bir yetikin, 24 saat içinde dört sodyum fosfat lavman aldktan sonra öldü; elektrolit anormallikleri vard ve kalp durmasndan öldü; [HSDB] Tavanlarda gözü hafif derecede tahri eder. Disodyum Fosfat (Na2HPO4), fosforik asidin bir sodyum tuzudur. Oldukça higroskopik olan beyaz bir tozdur. Toz ürünlerde topaklanmay önleyici katk maddesi olarak kullanlr.Bu çalmann amac, iddetli hipofosfatemiden muzdarip yetikinlerin tedavisinde 120 dakika boyunca sodyum veya potasyum fosfat olarak intravenöz olarak uygulanan 0.15 mmol / kg fosforun (PHOS) güvenliliini ve etkinliini belirlemekti. iddetli hipofosfatemi, | LE / 1.5 mg / dL’lik bir serum PHOS konsantrasyonu olarak tanmland. Dlama kriterleri böbrek yetmezlii ve hiperkalsemiydi. Hasta deerlendirmeleri zihinsel durum, kalp at hz ve kan basncn içeriyordu. nfüzyon sonras serum PHOS örneklemesinin zamanlamas doktorun takdirindedir. Çalmaya alt erkek ve dört kadn katld. Çalma süresi boyunca, uygulanan tek parenteral PHOS çalma dozu olmutur. PHOS uygulamasyla ilikili hiçbir hastada advers olay yoktu. Potasyum fosfat alan bir hastada infüzyon sonras serum potasyumu yükselmitir (5.2 mEq). Serum PHOS, on hastann tümünde iddetli hipofosfatemi için çalma kriterlerinin üzerine çkm, ancak dokuz hasta ezamanl oral PHOS takviyeleri almtr. iddetli hipofosfatemili hastalarn tedavisinde intravenöz sodyum veya potasyum fosfat dozu ampiriktir. Geçmiteki toksisite kant, dozlama önerilerinin düük ve yava olmasna neden olmutur. Bu veriler, hastann zihinsel durumu, yaamsal belirtiler ve kan kimyas analizi ile ölçüldüü üzere yetikinlere iki saatten fazla uygulandnda orta düzeyde bir PHOS dozunun güvenliini göstermektedir. Fosfor plazma ve dier hücre d svda, hücre zarlarnda ve hücre içi svda mevcuttur, yan sra kolajen ve kemik dokularnda. Hücre d svda bulunan fosfor esas olarak inorganik formdadr ve plazma seviyeleri yaa göre biraz deiebilir. Hücre d svdaki disodyum fosfat ve monosodyum fosfat oran 7,4’lük normal pH’ta 4’e 1’dir (% 80 ila% 20). Bu tampon oran pH ile deiir, ancak nispeten düük konsantrasyonu nedeniyle hücre d svnn tamponlama kapasitesine çok az katkda bulunur. Sodyum fosfatn barsak lümeninde bulunan çözünen madde miktarn artrarak çalt ve böylece bir ozmotik gradyan oluturduu düünülmektedir. Böbrek distal tübülünde, tübüler idrardaki sodyum karlnda tübüler hücre tarafndan hidrojenin salglanmas, dibazik fosfat tuzlarn monobazik fosfat tuzlarna dönütürür. Bu nedenle, idrarn pH’n tübüler hücre ile lümen svs arasndaki yüksek konsantrasyon gradyanyla hidrojen tanmasn engelleyecek bir dereceye düürmeden büyük miktarlarda asit atlabilir. Sodyum monofosfatlar genellikle fosforik asidin soda külü veya kostik soda ile nötralize edilmesiyle üretilir. kincisi arlkl olarak Almanya’da kullanlrken, Amerika Birleik Devletleri’nde daha ucuz olan soda külü hakimdir. Sodyum karbonatn baziklii trisodyum fosfat oluumu için yetersizdir, bu nedenle bu aamada kostik soda kullanlmas gerekir. Fosfatlar, çözeltilerden hidrat olarak kristalleir ve santrifüjleme ile ayrlr. Susuz tuzlar, döner kurutucularda dehidrasyon yoluyla veya dorudan püskürtmeli kurutma yoluyla veya döner frnlarda çözeltilerden elde edilir. Hem termal fosforik asit hem de daha ucuz slak fosforik asit, balangç ​​malzemeleri olarak kullanlr. Çok saf termal fosforik asit genellikle gda snf fosfatlarn üretiminde kullanlr.Fosfor, plazma ve dier hücre d svda, hücre zarlarnda ve hücre içi svda ve ayrca kollajen ve kemik dokularnda bulunur. Hücre d svda bulunan fosfor esas olarak inorganik formdadr ve plazma seviyeleri yaa göre biraz deiebilir. Hücre d svdaki Disodyum Fosfat ve monosodyum fosfat oran 7,4 normal pH’ta 4’e 1’dir (% 80 ila% 20). Bu tampon oran pH ile deiir, ancak nispeten düük konsantrasyonu nedeniyle hücre d svnn tamponlama kapasitesine çok az katkda bulunur.Disodyum Fosfat en büyük kullanm pastörize ilem peynirleri için emülsifiye edici bir yardmcdr. % 0.12-0.3 Disodyum Fosfat ilavesi ile agar jelin mukavemeti önemli ölçüde artrld.% 0.01-0.05 seviyelerinde berraklatrlm eker kam suyuna Disodyum Fosfat ilavesi, ekerlerin hidrolizi azald ve böylece karamelleme azald Disodyum Fosfat kalntlar, inert (veya ara sra aktif) maddeler olarak iyi tarm uygulamasna uygun olarak iyi tarm uygulamasna uygun olarak, katlama önleyici bir ajan olarak kullanldnda tolerans gerekliliinden muaftr. Yetitirilen ürünlere veya hasattan sonra ham tarmsal ürünlere uygulanan pestisit formülasyonlar Disodyum Fosfat kalntlar Büyüyen mahsullere veya hasattan sonra ham tarmsal ürünlere uygulanan pestisit formülasyonlarnda inert (veya ara sra aktif) bileenler olarak iyi tarm uygulamalarna uygun olarak iyi tarmsal uygulamalara uygun artlandrc ajan olarak kullanldnda tolerans gerekliliinden muaftr. Disodyum Fosfat nsan tüketimi için gdalarda tecrit maddesi olarak kullanlan, genellikle iyi imalat uygulamalarna uygun olarak kullanldnda güvenli olarak kabul edilir. D-tiroksin haricinde, test edilen hipokolesterolemik ajanlar, yüksek dozlarda Disodyum Fosfat ile tedavi edilen trombojenik diyet uygulayan sçanlarda kalp lezyonlarnn oluumunu engellememitir. Disodyum Fosfat 3 haftalk sçanlarda vitamin D3’ün antiraitik aktivitesini arttrd. Sçanlarda intraserebroventriküler (ICV) verilen fosfat Disodyum Fosfat, davransal ve EEG aktivasyonu, stereotipler, ar duyarllk ve analjezi ile karakterize bir sendrom ortaya çkard.