HALAMID (CHLORAMIN T)

HALAMID(CHLORAMINE-T)

CAS No. : 127-65-1

EC No. : 204-854-7

Synonyms:

Chloramine-T; CHLORAMINE T; 127-65-1; Chloralone; Chlorasan; Chlorozone; Tosylchloramide sodium; Acti-chlore; Chloraseptine; Chlorazene; Chlorazone; Chlorseptol; Multichlor; Tochlorine; Aktivin; Chlorazan; Chlorosol; Heliogen; Mannolite; Tampules; Tolamine; Sodium chloramine T; Chlorina Aktivin; Monochloramine T; Sodium tosylchloramide; Sodium p-toluenesulfonchloramide; Berkendyl; Anexol; Tosilcloramida sodica; Cloramine T; Tosylchloramide sodique; Tosylchloramidum natricum; Clorina; Euclorina; Aseptoclean; Gyneclorina; (N-Chloro-p-toluenesulfonamido)sodium; Clorosan; Desinfect; Kloramin; Mianine; Gansil; Tosylchloramid-natrium; Sodium p-toluenesulfonylchloramide; Chloramin Heyden; Kloramine-T; N-Chloro-p-toluenesulfonamide sodium; Sodium N-chloro-p-toluenesulfonamide; Sodium chloro(tosyl)amide; Chloramine-T hydrate; Halamid; Caswell No. 170; Chloramin Dr. Fahlberg; N-Chlorotoluenesulfonamide sodium salt; UNII-328AS34YM6; CHEBI:53767; HSDB 4303; N-Chloro-4-methylbenzylsulfonamide sodium salt; EINECS 204-854-7; Tosilcloramida sodica [INN-Spanish]; N-Chloro-4-methylbenzenesulfonamide sodium salt; NSC 36959; Tosylchloramide sodique [INN-French]; Tosylchloramidum natricum [INN-Latin]; AI3-18426C; EPA Pesticide Chemical Code 076502; Tosylchloramide sodium [INN]; p-Toluenesulfonamide, N-chloro-, sodium salt; sodium chloro(4-methylbenzenesulfonyl)azanide; 328AS34YM6; [chloro(p-tolylsulfonyl)amino]sodium; Benzenesulfonamide, N-chloro-4-methyl-, sodium salt; 149358-73-6; Tosylchloramide sodium (INN); Benzenesulfonamide, N-chloro-4-methyl-, sodium salt (1:1); Sodium derivative of N-chloro-p-toluenesulfonamide trihydrate; Chloramine-t [NF]; Chloramine-T / Tosylchloramide sodium; SR-01000872612; Chloramin T; Chloramine (T); (N-chloro-p-toluenesulfonamide)sodium; C7H7ClNO2S.Na; Epitope ID:116223; SCHEMBL19335; CHEMBL1697734; DTXSID6040321; CTK8E8209; HMS3264N19; BCP12015; HY-B0959; N-Chloro-4-toluenesulfonamide,sodiu; p-Toluenesulfonchloramide Sodium Salt; s6403; AKOS015890257; CCG-213937; CS-4435; KS-0000191O; SC-18993; LS-154121; Chloramine T (Tosyl Chloramide Sodium Salt); FT-0654742; EN300-75322; sodium chloro[(4-methylphenyl)sulfonyl]azanide; D02445; Z-0571; Q420695; J-008582; SR-01000872612-2; SR-01000872612-3; W-108379

EN

Halamid(Chloramine-T) IUPAC Name sodium;chloro-(4-methylphenyl)sulfonylazanide

Halamid(Chloramine-T) InChI InChI=1S/C7H7ClNO2S.Na/c1-6-2-4-7(5-3-6)12(10,11)9-8;/h2-5H,1H3;/q-1;+1

Halamid(Chloramine-T) InChI Key VDQQXEISLMTGAB-UHFFFAOYSA-N

Halamid(Chloramine-T) Canonical SMILES CC1=CC=C(C=C1)S(=O)(=O)[N-]Cl.[Na+]

Halamid(Chloramine-T) Molecular Formula C7H7ClNNaO2S

Halamid(Chloramine-T) CAS 127-65-1

Halamid(Chloramine-T) Related CAS 144-86-5 

Halamid(Chloramine-T) Deprecated CAS 1576-40-5, 72793-59-0

Halamid(Chloramine-T) European Community (EC) Number 204-854-7

Halamid(Chloramine-T) ICSC Number 0413

Halamid(Chloramine-T) RTECS Number XT5616800

Halamid(Chloramine-T) UN Number 1759

Halamid(Chloramine-T) UNII 328AS34YM6

Halamid(Chloramine-T) DSSTox Substance ID DTXSID6040321

Halamid(Chloramine-T) Physical Description WHITE SOLID IN VARIOUS FORMS WITH CHARACTERISTIC ODOUR.

Halamid(Chloramine-T) Color/Form White or slightly yellow crystals or crystalline powder

Halamid(Chloramine-T) Odor Slight odor of chlorine

Halamid(Chloramine-T) Melting Point 170-177 °C decomposes

Halamid(Chloramine-T) Flash Point 192 °C 

Halamid(Chloramine-T) Solubility nsoluble in benzene, chloroform, and ether; decomposed by alcohol

Halamid(Chloramine-T) Density Density (trihydrate): 1.4 g/cm³

Halamid(Chloramine-T) LogP log Kow = 0.84

Halamid(Chloramine-T) Stability/Shelf Life Decomposes slowly in air, liberating chlorine /trihydrate/

Halamid(Chloramine-T) Decomposition When heated to decomposition it emits toxic fumes of /hydrogen chloride, nitrogen oxides, sulfur oxides, and sodium oxides/

Halamid(Chloramine-T) Other Experimental Properties Prisms; loses water upon drying; fairly soluble in water; practically insoluble in benzene, chloroform, and ether; decomposed by alcohol /Trihydrate/

Halamid(Chloramine-T) Molecular Weight 227.64 g/mol

Halamid(Chloramine-T) Hydrogen Bond Donor Count 0

Halamid(Chloramine-T) Hydrogen Bond Acceptor Count 3

Halamid(Chloramine-T) Rotatable Bond Count 1

Halamid(Chloramine-T) Exact Mass 226.978372 g/mol

Halamid(Chloramine-T) Monoisotopic Mass 226.978372 g/mol

Halamid(Chloramine-T) Topological Polar Surface Area 43.5 Ų

Halamid(Chloramine-T) Heavy Atom Count 13

Halamid(Chloramine-T) Formal Charge 0

Halamid(Chloramine-T) Complexity 231

Halamid(Chloramine-T) Isotope Atom Count 0

Halamid(Chloramine-T) Defined Atom Stereocenter Count 0

Halamid(Chloramine-T) Undefined Atom Stereocenter Count 0

Halamid(Chloramine-T) Defined Bond Stereocenter Count 0

Halamid(Chloramine-T) Undefined Bond Stereocenter Count 0

Halamid(Chloramine-T) Covalently-Bonded Unit Count 2

Halamid(Chloramine-T) Compound Is Canonicalized Yes

Halamid(Chloramine-T) (HDDA and sometimes called HDODA) is a difunctional acrylate ester monomer used in the manufacture of polymers.It is particularly useful for use in ultraviolet light cure applications.Furthermore, it is also used in adhesives, sealants, alkyd coatings, elastomers, photopolymers, and inks for improved adhesion, hardness, abrasion and heat resistance.Like other acrylate monomers it is usually supplied with a radical inhibitor such as hydroquinone added.The material is prepared by acid-catalyzed esterification of 1,6-hexanediol with acrylic acid.As the molecule has acrylic functionality, it is capable of undergoing the Michael reaction with an amine. This allows it use in epoxy chemistry where its use speeds up the cure time considerably.Halamid(Chloramine-T) is a clear yellow liquid.Halamid(Chloramine-T) is a global brand widely used by professionals thanks to its long lasting proven efficacy.The surprising properties of Halamid(Chloramine-T) in combination with our expertise gained over 60 years, makes Axcentive stand out. Halamid(Chloramine-T) is your professional disinfectant whenever hygiene is required.Halamid(Chloramine-T) is employed as an essential and reliable disinfectant for aquaculture for many years with its good efficacy and low toxicity to fish, shrimp and aquatic environments. Halamid(Chloramine-T) is used in salt, brackish and fresh water environments.Halamid(Chloramine-T) has found wide application in flow-through raceways, stagnant ponds and closed circuit systems. Fish farmers have since long trusted Halamid(Chloramine-T) against parasitic diseases such as Amoebic Gill Disease (AGD), White spot and Costia as well as bacterial diseases such as Vibriosis, Columnaris and Bacterial Gill Disease (BGD).Disinfection of tanks and ponds, nets, equipment, well boats and in the fish processing industry with Halamid(Chloramine-T) ensures that pathogenic microorganisms are rapidly and effectively destroyed.As with any biocide protection measures are required, but Halamid(Chloramine-T) can be handled by using standard personal equipment. Halamid(Chloramine-T) is the safe alternative for traditional and more dangerous chemicals. It is non-toxic for fish and shrimp at effective dosage and does not leave residues in the animals.With its readily biodegradable action, Halamid(Chloramine-T) is the safe alternative for dangerous chemicals does not accumulate in river beds and is not toxic to the aquatic environment.Halamid(Chloramine-T) is proven powerful yet mild disinfectant ideally suited to be used by poultry farmers in broiler houses, hatcheries and layer farms. Halamid(Chloramine-T) is notified under the EU BPR regulation and UK DEFRA approved among many other registrations around the world.An effective biosecurity program based on Halamid(Chloramine-T) brings the total bacterial and viral load in the poultry house down to a safe level. Halamid(Chloramine-T) eradicates all major poultry pathogens such as Salmonella, Avian Influenza, Campylobacter, New Castle Disease or Gumboro at 0.5% (1:200), following European norms. Hence it gives vital support to poultry health programs while at the same time reducing the need to use antibiotics to a minimum. Allowing staff to use one single product for several risk areas at a time quickly creates efficiency in work and the need for less disinfectant stock resulting in lower costs and all-round improvement.Halamid(Chloramine-T) can be safely handled with standard personal equipment, which is routine for the use of any professional hygiene product. Halamid(Chloramine-T) is therefore the safe alternative for traditional and more dangerous chemicals, preferred by poultryfarmers.The environmental burden of disinfectants are important to consider. Halamid(Chloramine-T) is readily biodegradable, does not accumulate in river beds unlike other more dangerous substances. Extensive studies have shown that the ecotoxicity of Halamid(Chloramine-T) is low.Halamid(Chloramine-T) is a powerful disinfectant that eradicates all major problem-causing microorganisms.Halamid(Chloramine-T) is the proper disinfectant when it comes to hygiene of buildings, industrial plants, hospitals, and equipment.Due to its broad activity spectrum and its ease of dissolving in water, Halamid(Chloramine-T) is widely used in food processing and drinking water systems.Biosecurity is key in farms and veterinary hygiene, all along the ‘farm to fork’ chain and starts by effective disinfection. Halamid(Chloramine-T) has been developed from the starting point of a strong killing effect and by greatly improving aspects such as stability is solution, corrosiveness and safety compared to more hazardous products.Enter into the Halamid(Chloramine-T) sphere and refer to specific segments in aquaculture, poultry, pig or cattle farming to learn more about Halamid(Chloramine-T)’s uniqueness, efficacy, application methods or concentrations.Halamid(Chloramine-T) is the ideal dairy cattle disinfectant suitable for cow teat disinfection and prevention of contamination of equipment.Halamid(Chloramine-T) is the preferred disinfectant for swine farms and is amongst others proven effective against Lawsonia intracellularis.It has also been put into service of our country’s businesses. Halamid(Chloramine-T)-food offers a definitive solution to the HYGIENE problems of our businesses with its effective safety, effective use, ecological structure and economical product options. Food Production Facilities (meat combinations, egg-containing food production, dessert, chocolate, biscuit, canned food, tomato paste, frozen and dry food, beverage industry, brewery, milk processing plants, ice cream, dairies …) Drinking Water Filling Facilities and Food Presentation and It is used by businesses that distribute (hotel kitchens, dining halls, restaurants, cathering companies, cafes …). Halamid(Chloramine-T) is concentrated; in tablet and powder form. Its active ingredient is sodium-N-chloropala toluensulphonechloramide (Chloramin-T), which is extremely effective and active. (Note: Said toluene is organic.) Other 11 microcrystalline raw materials hidden in its structure are of DAB 10 quality. This provides fast solution in water (30 seconds) and 3.5 YEARS SHELF LIFE WARRANTY, provided that it is stored under 25 ° C in its original package. The action mechanism of Halamid(Chloramine-T) is triggered when it is diluted. The active groups within it become active in direct proportion to the microorganism density and adhere to its body. With this feature, it provides a certain order and stability in the cost structure of the enterprise. As a result of the clinical tests and researches carried out so far, no microorganism has been detected for which Halamid(Chloramine-T) is not effective. Bacteria (Gram -, +), Viruses (Enveloped, non-enveloped), Microbacteria, Fungus, Yeast, Spores. (Microorganisms with proven efficacy with clinical trials – duration of action are stated in the Appendix.) Since Halamid(Chloramine-T) completely oxidizes microorganisms, resistance formation is not possible. Halamid(Chloramine-T) disappears in nature in a short time. It brings a unique solution to businesses in compliance with the (Environmental Health) conditions, which increase its importance day by day in international regulations. Halamid(Chloramine-T) does not leave active residue. Halamid(Chloramine-T) tablets and powder products offer 3.5 years of shelf life guarantee under 25 C in dry and dark environment. When Halamid(Chloramine-T) is prepared in different concentration ratios, it is easily used for surface and area disinfection, environment disinfection, disinfection of tools and equipment, water disinfection, disinfection of fruits and vegetables, foot pools, hand hygiene, sterilization of some cutting tools (dipping method).Halamid(Chloramine-T) Usage:Used in the pharmaceutical industry to prepare sterilizing agents, sulfonamides, indicators. Halamid(Chloramine-T) Package:25kg/Drum. Halamid(Chloramine-T) Storage:It should be placed in tight container,avoiding light.Use of Halamid(Chloramine-T) and two dyes in the sensitive determination of stavudine in pharmaceuticals.Three new methods are described for the assay of stavudine (STV) in bulk drug and in dosage forms using Halamid(Chloramine-T) (CAT) and two dyes, methyl orange and indigocarmine, as reagents. Titrimetry involves treating STV with a measured excess of Halamid(Chloramine-T) in hydrochloric acid medium, and after the oxidation of STV is judged to be complete, the unreacted oxidant is determined iodometrically. Spectrophotometric methods entail the addition of a known excess of Halamid(Chloramine-T) to STV in hydrochloric acid medium followed by determination of residual oxidant by reacting with a fixed amount of either methyl orange and measuring the absorbance at 520 nm (Method A) or indigo carmine and measuring the absorbance at 610 nm (Method B). In all the methods, the amount of Halamid(Chloramine-T) reacted corresponds to the amount of STV. In titrimetric method, the reaction follows 1:1 stoichiometry (STV: Halamid(Chloramine-T)), and is applicable over the range 1.5-10 mg of STV. In spectrophotometric methods, the absorbance is found to increase linearly with concentration of STV.In this communication, we report one titrimetric and two spectrophotometric methods for the determination of STV in bulk drug and in pharmaceutical formulations. The methods are based on the oxidation of STV by Halamid(Chloramine-T) followed by estimation of unreacted oxidant by iodometric back titration (titrimetry) or reacting with a fixed amount of dye (spectrophotometry). The methods were applied to the determination of STV in different proprietary drugs and were found to yield satisfactory results.A 10.0 mL aliquot of pure drug solution equivalent to 1.5-10.0 mg of STV was measured accurately and transferred into a 100 mL titration flask. Five mL 1 M hydrochloric acid followed by 10 mL of 0.01 M Halamid(Chloramine-T) solution were added and kept aside for 10 min with occasional swirling. Then, 5 mL of 10% potassium iodide solution were added to the flask and the liberated iodine was titrated with 0.02 M sodium thiosulphate to a starch end point. A blank titration was run under same conditions. The amount of the drug present in the measured aliquot was calculated from the volume of Halamid(Chloramine-T) that has reacted with the drug.Aliquots of pure STV solution (0.4 to 4.0 mL; 5.0 µg/mL) were transferred into a series of 10 mL calibrated flasks and the total volume was adjusted to 4.0 mL with water. To each flask were added 1 mL of 5 M hydrochloric acid followed by 1 mL of Halamid(Chloramine-T) solution (50.0 µg/mL). The content was mixed well and the flasks were set aside for 10 min with occasional shaking. Finally, 1 mL of 50.0 µg/mL methyl orange solution was added to each flask, diluted to the mark with water and the absorbance of solution was measured at 520 nm against reagent blank after 10 min.The proposed methods are based on the oxidation of STV by Halamid(Chloramine-T) in HCl medium and the reaction is followed by titrimetry and spectrophotometry for quantization purposes. In titrimetry, the unreacted Halamid(Chloramine-T) is determined iodometrically, and in spectrophotometric methods, the same is determined by reacting with a fixed amount of either methyl orange or indigo carmine. The latter methods make use of the bleaching action of Halamid(Chloramine-T) on either dye, the decolouration being caused by the oxidative destruction of the dye.The reaction stoichiometry was found to be 1:1(STV: Halamid(Chloramine-T)) which was unaffected in the presence of 3 to 8 mL of 1M HCl in a total volume of 25 mL and hence 5 mL of 1M HCl was chosen as the optimum volume. The oxidation reaction was found to be complete in 10 min and contact time upto 30 min had no effect on the stoichiometry or the results. A 10 mL volume of 0.01M Halamid(Chloramine-T) solution was found adequate for the quantitative oxidation of STV in 1.5 to 10.0 mg range. The linearity between the amount of drug and titration end point is apparent from the calculated correlation coefficient of –0.9964 suggesting that the reaction between STV and Halamid(Chloramine-T) proceeds stoichiometrically in the ratio of 1:1, in the optimum range (1.5-10.0 mg). Based on the reaction stoichiometry, a tentative reaction scheme shown in Figure 1 is suggested.In the proposed spectrophotometric methods, the ability of Halamid(Chloramine-T) to effect oxidation of STV and irreversibly destroy methyl orange or indigo carmine to colourless products in acid medium has been used. STV when added in increasing concentrations to a fixed concentration of Halamid(Chloramine-T), consumes the latter and there will be a concomitant decrease in its concentration. When a fixed concentration of either dye is added to decreasing concentrations of Halamid(Chloramine-T), a concomitant increase in the concentration of dye results and a proportional increase in the absorbance at the respective lmax is observed with increasing concentration of STV.Preliminary experiments were performed to fix the upper limits of the dyes that could be determined spectrophotometrically, and these were found to be 5.0 and 20.0 µg/mL for methyl orange and indigo carmine, respectively. A Halamid(Chloramine-T) concentration of 5.0 µg/mL was found to irreversibly destroy the red colour of 5.0 µg/mL methyl orange whereas 20.0 µg/mL Halamid(Chloramine-T) was required to bleach the blue colour due to 22.5 µg/mL indigo carmine. Hence, different amounts of STV were reacted with 1 mL of 50.0 µg/mL Halamid(Chloramine-T) in method A and 1mL of 225.0 µg/mL Halamid(Chloramine-T) in method B followed by determination of the residual oxidant as described under the respective procedures.For both oxidation of STV and bleaching of dye by Halamid(Chloramine-T), hydrochloric acid medium was found to be ideal. One mL of 5 M hydrochloric acid for method A and 2 mL of 2 M HCl for method B, in a total volume of ~4-5 mL were adequate for the oxidation step which was complete in 10 min in both methods and the same quantity of acid was employed for the estimation of the dye. Contact time of 10 min is not critical and any delay upto 30 min had no effect on the absorbance. The absorbance of either dye colour was stable for several hours in the presence of reaction product.Halamid(Chloramine-T) is a titrimetric reagent, and an oxidizing agent. Halamid(Chloramine-T) is an oxidizing biocide.Kinetics of chlorination of substituted phenols with a particular emphasis on p‐nitrophenol (PNP) have been extensively studied using Halamid(Chloramine-T) (CAT).PNP gave a straight line with a finite intercept. In aqueous dimethylformamide (DMF) and dimethylsulfoxide (DMSO) the reaction shows a second‐order dependence on Halamid(Chloramine-T) and a first‐order dependence on PNP in the case of DMF and a slight increment in order in DMSO. Addition of water increases the rate both in aqueous acetic acid and in dipolar aprotic solvents such as DMF and DMSO. The order of the reaction with respect to Halamid(Chloramine-T) is found to be dependent on pH as well as the reactivity of the phenols. In buffered acetic acid medium a second‐order dependence on Halamid(Chloramine-T) was followed up to pH 7. The rate variations with temperature in the range of 30°¨Dot;50°C have been studied for all the substituted phenols, and the respective activation parameters have been calculated. The empirical rate law is accounted for by a mechanism involving species generated from Halamid(Chloramine-T) complexing PNP. Protonated Halamid(Chloramine-T),and dichloramine T (DCT) are considered important depending on reaction media. The effect of salts, pH, structural variations, and solvent dependence have been accounted for by the proposed mechanism. An attack by positive chlorine on oxygen of the phenol is the preferred mode of attack.

TR

Halamid(Chloramine-T) IUPAC Ad sodyum; kloro- (4-metilfenil) sülfonilazanid

Halamid(Chloramine-T) InChI InChI = 1S / C7H7ClNO2S.Na / c1-6-2-4-7 (5-3-6) 12 (10,11) 9-8; / h2-5H, 1H3; / q-1; +1

Halamid(Chloramine-T) InChI Anahtar VDQQXEISLMTGAB-UHFFFAOYSA-N

Halamid(Chloramine-T) Kanonik SMILES CC1 = CC = C (C = C1) S (= O) (= O) [N-] Cl. [Na +]

Halamid(Chloramine-T) Moleküler Formül C7H7ClNNaO2S

Halamid(Chloramine-T) CAS 127-65-1

Halamid(Chloramine-T) le lgili CAS 144-86-5

Halamid(Chloramine-T) Kullanmdan Kaldrld CAS 1576-40-5, 72793-59-0

Halamid(Chloramine-T) Avrupa Topluluu (EC) Numaras 204-854-7

Halamid(Chloramine-T) ICSC Numaras 0413

Halamid(Chloramine-T) RTECS Numaras XT5616800

Halamid(Chloramine-T) UN Numaras 1759

Halamid(Chloramine-T) UNII 328AS34YM6

Halamid(Chloramine-T) DSSTox Madde Kimlii DTXSID6040321

Halamid(Chloramine-T) Fiziksel Tanm KARAKTERSTK KOKULU ÇETL FORMLARDA BEYAZ KATI.

Halamid(Chloramine-T) Renk / Form Beyaz veya hafif sar kristaller veya kristal toz

Halamid(Chloramine-T) Koku Hafif klor kokusu

Halamid(Chloramine-T) Erime Noktas 170-177 ° C ayrr

Halamid(Chloramine-T) Parlama Noktas 192 ° C

Halamid(Chloramine-T) Çözünürlüü Benzen, kloroform ve eter içinde çözünür; alkolle parçalanm

Halamid(Chloramine-T) Younluk Younluu (trihidrat): 1,4 g / cm³

Halamid(Chloramine-T) LogP log Kow = 0.84

Halamid(Chloramine-T) Stabilitesi / Raf Ömrü Havada yavaça ayrarak klor / trihidrat /

Halamid(Chloramine-T) Ayrmas Ayrmaya kadar stldnda / hidrojen klorür, nitrojen oksitler, sülfür oksitler ve sodyum oksitlerin toksik dumanlar çkarr.

Halamid(Chloramine-T) Dier Deneysel Özellikler Prizmalar; kuruduktan sonra su kaybeder; suda oldukça çözünür; benzen, kloroform ve eterde pratik olarak çözünmez; alkol / Trihidrat ile parçalanm

Halamid(Chloramine-T) Moleküler Arlk 227.64 g / mol

Halamid(Chloramine-T) Hidrojen Ba Donör Says 0

Halamid(Chloramine-T) Hidrojen Ba Alc Says 3

Halamid(Chloramine-T) Dönebilen Tahvil Says 1

Halamid(Chloramine-T) Tam Kütle 226.978372 g / mol

Halamid(Chloramine-T) Monoizotopik Kütle 226.978372 g / mol

Halamid(Chloramine-T) Topolojik Polar Yüzey Alan 43,5 Ų

Halamid(Chloramine-T) Ar Atom Says 13

Halamid(Chloramine-T) Resmi arj 0

Halamid(Chloramine-T) Karmakl 231

Halamid(Chloramine-T) zotop Atom Says 0

Halamid(Chloramine-T) Tanml Atom Stereocenter Says 0

Halamid(Chloramine-T) Tanmsz Atom Stereocenter Says 0

Halamid(Chloramine-T) Tanml Bond Stereocenter Says 0

Halamid(Chloramine-T) Tanmsz Ba Stereocenter Says 0

Halamid(Chloramine-T) Kovalent Bal Birim Says 2

Halamid(Chloramine-T) Bileii Kanonikletirilmitir Evet

Halamid(Chloramine-T) (HDDA ve bazen HDODA olarak da adlandrlr) polimer üretiminde kullanlan iki ilevli bir akrilat ester monomeridir.Özellikle ultraviyole kla kürleme uygulamalarnda kullanm için faydaldr.Ayrca yaptrclar, szdrmazlk maddeleri, alkid kaplamalar, elastomerler, fotopolimerlerde de kullanlr. ve daha iyi yapma, sertlik, anma ve s direnci için mürekkepler. Dier akrilat monomerler gibi, genellikle hidrokinon gibi bir radikal inhibitör eklenmitir. Malzeme 1,6-heksandiolün akrilik asit ile asit katalizli esterletirilmesi ile hazrlanr. Molekül akrilik ilevsellie sahip olduundan, bir amin ile Michael reaksiyonuna girebilir. Bu, kullanmnn kürlenme süresini önemli ölçüde hzlandrd epoksi kimyasnda kullanlmasna izin verir.Halamid(Chloramine-T), berrak sar bir svdr.Halamid(Chloramine-T), uzun süreli kantlanm etkinlii sayesinde profesyoneller tarafndan yaygn olarak kullanlan küresel bir markadr. 60 yl akn süredir kazanlan uzmanlk Axcentive’ öne çkaryor. Halamid(Chloramine-T), hijyen gerektiinde profesyonel dezenfektannzdr.Halamid(Chloramine-T), balk, karides ve su ortamlarna düük toksisitesi ve iyi etkinlii ile uzun yllar su ürünleri yetitiriciliinde vazgeçilmez ve güvenilir bir dezenfektan olarak kullanlmaktadr. Halamid(Chloramine-T), tuzlu, ac su ve tatl su ortamlarnda kullanlmaktadr.Halamid(Chloramine-T), geçili kanallarda, durgun havuzlarda ve kapal devre sistemlerinde geni uygulama alan bulmutur. Balk çiftçileri, Amipli Solungaç Hastal (AGD), Beyaz nokta ve Costia gibi parazitik hastalklarn yan sra Vibriosis, Columnaris ve Bakteriyel Solungaç Hastal (BGD) gibi bakteriyel hastalklara kar uzun zamandr Halamid(Chloramine-T)’e güveniyor. Tanklarn ve havuzlarn, alarn, ekipmanlarn dezenfeksiyonu , kuyu tekneleri ve Halamid(Chloramine-T) ile balk ileme endüstrisinde patojen mikroorganizmalarn hzl ve etkili bir ekilde yok edilmesini salar.Her türlü biyosit koruma önlemlerinde olduu gibi, ancak Halamid(Chloramine-T) standart kiisel ekipman kullanlarak kullanlabilir. Halamid(Chloramine-T), geleneksel ve daha tehlikeli kimyasallar için güvenli bir alternatiftir. Etkin dozajda balk ve karides için toksik deildir ve hayvanlarda kalnt brakmaz.Halamid(Chloramine-T), biyolojik olarak kolayca parçalanabilen etkisi ile nehir yataklarnda birikmeyen ve su ortamna toksik olmayan tehlikeli kimyasallar için güvenli bir alternatiftir. Halamid(Chloramine-T), kümes hayvan çiftçileri tarafndan broyler kümeslerinde, kuluçkahanelerde ve yumurtac çiftliklerinde kullanlmak üzere ideal olarak uygun olduu kantlanm güçlü ancak hafif bir dezenfektandr. Halamid(Chloramine-T), AB BPR yönetmelii kapsamnda bildirilir ve dünyadaki dier birçok kayt arasnda Birleik Krallk DEFRA onayldr.Halamid(Chloramine-T)’e dayal etkili bir biyogüvenlik program, kümes içindeki toplam bakteri ve viral yükü güvenli bir seviyeye indirir. Halamid(Chloramine-T), Avrupa normlarna göre Salmonella, Avian Influenza, Campylobacter, New Castle Disease veya Gumboro gibi tüm büyük kümes hayvan patojenlerini% 0,5 (1: 200) orannda ortadan kaldrr. Böylelikle kanatl sal programlarna hayati destek verirken ayn zamanda antibiyotik kullanma ihtiyacn en aza indirir. Personelin ayn anda birden fazla risk alan için tek bir ürün kullanmasna izin vermek, ite verimlilik ve daha az dezenfektan stou ihtiyac ile sonuçlanarak daha düük maliyetler ve çok yönlü iyiletirme salar.Halamid(Chloramine-T) için rutin olan standart kiisel ekipmanla güvenli bir ekilde kullanlabilir. herhangi bir profesyonel hijyen ürününün kullanm. Bu nedenle Halamid(Chloramine-T), kümes hayvanlar yetitiricileri tarafndan tercih edilen geleneksel ve daha tehlikeli kimyasallar için güvenli bir alternatiftir. Dezenfektanlarn çevresel yükünün dikkate alnmas önemlidir. Halamid(Chloramine-T) biyolojik olarak kolaylkla parçalanabilir, dier tehlikeli maddelerden farkl olarak nehir yataklarnda birikmez. Kapsaml çalmalar, Halamid(Chloramine-T)’in ekotoksisitesinin düük olduunu göstermitir.Halamid(Chloramine-T), problem yaratan tüm önemli mikroorganizmalar ortadan kaldran güçlü bir dezenfektandr. Geni aktivite yelpazesi ve suda çözülme kolayl olan Halamid(Chloramine-T), gda ileme ve içme suyu sistemlerinde yaygn olarak kullanlmaktadr.Biyogüvenlik, çiftliklerde ve veteriner hijyeninde, tüm ‘tarladan çatala’ zinciri boyunca anahtardr ve etkili dezenfeksiyonla balar. Halamid(Chloramine-T), güçlü bir öldürme etkisinin balangç ​​noktasndan ve daha tehlikeli ürünlere kyasla kararllk, çözelti, andrclk ve güvenlik gibi yönleri büyük ölçüde iyiletirerek gelitirilmitir. Halamid(Chloramine-T) alanna girin ve su ürünleri yetitiricilii, kümes hayvanlar, domuz veya Halamid(Chloramine-T)’in benzersizlii, etkililii, uygulama yöntemleri veya konsantrasyonlar hakknda daha fazla bilgi edinmek için sr yetitiricilii. salamid, inek meme dezenfeksiyonu ve ekipmann kontaminasyonunun önlenmesi için ideal süt srlar dezenfektandr. alamid domuz çiftlikleri için tercih edilen dezenfektandr ve dierlerinin arasnda etkili olduu kantlanmtr. Lawsonia intracellularis.Ülkemiz iletmelerinin de hizmetine sunulmutur. Halamid(Chloramine-T)-food etkin güvenlii, efektif kullanm, ekolojik yaps ve ekonomik ürün seçenekleriyle iletmelerimizin HJYEN problemlerine Kesin Çözüm Sunmaktadr.Halamid(Chloramine-T) ; Gda Üretim Tesisleri (et kombinalar, yumurta içerikli gda üretimi, tatl, çikolata, bisküvi, konserve, salça, dondurulmu ve kuru gda, içecek sektörü, biraclk, süt ileme tesisleri, dondurma, mandralar..) çme Suyu Dolum Tesisleri ve Gda Sunum ve Datm yapan iletmelerce (otel mutfaklar, yemekhaneler, restoranlar, cathering irketleri, cafeler..) kullanlmaktadr.Halamid(Chloramine-T) konsantre olup; tablet ve toz halindedir. Etken maddesi son derece efektif ve aktif olan sodium-N-chloropala toluensulphonechloramide (Chloramin-T) dir. (Not: Sözü geçen toluen organik’tir.) Bünyesinde sakl olan dier 11 mikrokristalize hammadde DAB 10 kalitesindedir. Bu suda hzl çözümü (30 saniye) ve orijinal ambalajnda 25’C altnda depolama kouluyla 3,5 YIL RAF ÖMRÜ Garantisi salar. Halamid(Chloramine-T) ‘in aksiyon mekanizmas sulandrldnda tetiklenir.Bünyesindeki aktif guruplar mikroorganizmal younluk ile doru orantl olarak aktif hale geçer ve bünyesine yapr.Bu özelliiyle iletmenin maliyet yapsnda belli bir düzen ve istikrar salar. u ana kadar yaplm olan klinik testler ve aratrmalar sonucu Halamid(Chloramine-T)’in etkili olmad herhangi bir mikroorganizma saptanmamtr. Bakteriler (Gram-,+),Virüsler (Zarfl,zarfsz), Mikrobakteriler ,Mantar , Maya, Sporlar . (EK’te klinik deneylerle etkinlii kantlanm mikroorganizmalar – etki süreleri belirtilmektedir.) Halamid(Chloramine-T) Mikroorganizmalar tamamen oxidize ettiinden direnç oluumu mümkün deildir.Halamid(Chloramine-T) dogada ksa bir süre içinde yok olur.AOX oluumunun önemsenmeyecek seviyede az oldugu klinik deneylerle ispatlanmtr. Uluslararas talimatnamelerde gün geçtikçe önemini arttran (Çevre Saglg ) artlarna uyumda letmelere esiz bir çözüm getirir.Halamid(Chloramine-T) aktif kalnt brakmaz.Halamid(Chloramine-T) tablet ve toz ürünler 25 C nin altnda kuru ve karanlk ortamda 3,5 yl raf ömrü garantisi sunmaktadr.Halamid(Chloramine-T)’in sert sularda aktivasyonu maxsimumdur.Halamid(Chloramine-T) Farkl konsantrasyon oranlarnda hazrlandgnda yüzey ve alan dezenfeksiyonu, ortam dezenfeksiyon, alet ve ekipmanlarn dezenfeksiyonu, su dezenfeksiyonu, meyve ve sebzelerin dezenfeksiyonu, ayak havuzlar, el hijyeni,baz kesici aletlerin sterilizasyonu (daldrma yöntemi) rahatlkla kullanlr.Halamid(Chloramine-T) Kullanm: laç endüstrisinde sterilize edici ajanlar, sülfonamidler, indikatörler hazrlamak için kullanlr. Halamid(Chloramine-T) Paketi: 25kg / Tambur. Halamid(Chloramine-T) Saklama: Sk bir kaba konulmal, ktan kaçnlmaldr.laçlarda stavudinin hassas tayininde Halamid(Chloramine-T) ve iki boyann kullanlmas. Stavudinin (STV) toplu ilaçta tayini için üç yeni yöntem tanmlanmtr Reaktif olarak Halamid(Chloramine-T) (CAT) ve iki boya, metil portakal ve indigokarmin kullanan dozaj formlarnda. Titrimetri, STV’nin hidroklorik asit ortamnda ölçülen bir Halamid(Chloramine-T) fazlasyla ilemden geçirilmesini içerir ve STV’nin oksidasyonunun tamamlandna karar verildikten sonra reaksiyona girmemi oksidan iyodometrik olarak belirlenir. Spektrofotometrik yöntemler, hidroklorik asit ortamnda STV’ye bilinen fazla Halamid(Chloramine-T)’nin eklenmesini ve ardndan sabit miktarda metil turuncusu ile reaksiyona sokularak ve 520 nm’de (Yöntem A) veya indigo karmininde absorbans ölçülerek kalnt oksidann belirlenmesini gerektirir ve 610 nm’de emilimin ölçülmesi (Yöntem B). Tüm yöntemlerde reaksiyona giren Halamid(Chloramine-T) miktar STV miktarna karlk gelir. Titrimetrik yöntemde, reaksiyon 1: 1 stokiyometriyi (STV: Halamid(Chloramine-T)) izler ve 1.5-10 mg STV aralnda uygulanabilir. Spektrofotometrik yöntemlerde, absorbansn STV konsantrasyonu ile dorusal olarak artt bulunmutur. Bu iletiimde, STV’nin toplu ilaç ve farmasötik formülasyonlarda belirlenmesi için bir titrimetrik ve iki spektrofotometrik yöntem bildiriyoruz. Yöntemler, STV’nin Halamid(Chloramine-T) ile oksidasyonunu takiben reaksiyona girmemi oksidann iyodometrik geri titrasyon (titrimetri) ile tahminine veya sabit bir boya miktar ile reaksiyona girmesine (spektrofotometri) dayanmaktadr. Yöntemler, farkl tescilli ilaçlarda STV tayinine uyguland ve tatmin edici sonuçlar verdii görüldü. 1,5-10,0 mg STV’ye edeer 10,0 mL’lik saf ilaç çözeltisi tam olarak ölçüldü ve 100 mL’lik bir titrasyon iesine aktarld. Be mL 1 M hidroklorik asit ve ardndan 10 mL 0.01 M Halamid(Chloramine-T) çözeltisi ilave edildi ve ara sra döndürülerek 10 dakika bekletildi. Daha sonra, ieye 5 mL% 10 potasyum iyodür çözeltisi ilave edildi ve serbest kalan iyot, 0.02 M sodyum tiyosülfat ile bir niasta uç noktasna kadar titre edildi. Ayn koullar altnda bo bir titrasyon yapld. Ölçülen alikotta bulunan ilaç miktar, ilaçla reaksiyona giren Halamid(Chloramine-T) hacminden hesapland. Saf STV solüsyonunun likitleri (0.4 ila 4.0 mL; 5.0 µg / mL) 10 mL’lik bir seriye aktarld kalibre edilmi ieler ve toplam hacim su ile 4.0 mL’ye ayarland. Her ieye 1 mL 5 M hidroklorik asit ve ardndan 1 mL Halamid(Chloramine-T) çözeltisi (50.0 ug / mL) ilave edildi. çerik iyice kartrld ve ieler ara sra çalkalanarak 10 dakika kenara brakld. Son olarak, her ieye 1 mL 50.0 µg / mL metil portakal solüsyonu eklenmi, iarete kadar su ile seyreltilmi ve solüsyonun absorbans, 10 dakika sonra bo reaktif karsnda 520 nm’de ölçülmütür. HCl ortamnda Halamid(Chloramine-T) ile STV ve reaksiyonu niceleme amaçl titrimetri ve spektrofotometri takip eder. Titrimetrede, reaksiyona girmemi Halamid(Chloramine-T) iyodometrik olarak belirlenir ve spektrofotometrik yöntemlerde ayn, sabit miktarda metil portakal veya indigo karmin ile reaksiyona sokularak belirlenir. kinci yöntemler, Halamid(Chloramine-T)’nin her iki boya üzerindeki aartma etkisinden yararlanmaktadr, dekolorasyon boyann oksidatif ykmndan kaynaklanmaktadr. Reaksiyon stokiyometrisinin 1: 1 olduu bulunmutur (STV: Halamid(Chloramine-T)) Toplam 25 mL hacimde 3 ila 8 mL 1M HCl varl ve dolaysyla 5 mL M HCl optimum hacim olarak seçilmitir. Oksidasyon reaksiyonunun 10 dakikada tamamland ve 30 dakikaya kadar olan temas süresinin stokiyometri veya sonuçlar üzerinde hiçbir etkisi olmad bulundu. 1.5 ila 10.0 mg aralnda STV’nin kantitatif oksidasyonu için 10 mL hacim 0.01 M Halamid(Chloramine-T) çözeltisi yeterli bulunmutur. laç miktar ile titrasyon biti noktas arasndaki dorusallk, hesaplanan korelasyon katsays olan –0.9964’ten anlalr ve STV ile Halamid(Chloramine-T) arasndaki reaksiyonun stokiyometrik olarak optimum aralkta (1.5-10.0 mg) 1: 1 orannda ilerlediini gösterir. ). Reaksiyon stokiyometrisine dayanarak, ekil 1’de gösterilen geçici bir reaksiyon emas önerilmektedir. Önerilen spektrofotometrik yöntemlerde, Halamid(Chloramine-T)’nin STV’nin oksidasyonunu etkileme ve metil portakal veya indigo karmini asit ortamdaki renksiz ürünlere geri döndürülemez ekilde yok etme yetenei salanmtr. Kullanlm. STV, sabit bir Halamid(Chloramine-T) konsantrasyonuna artan konsantrasyonlarda eklendiinde ikincisini tüketir ve konsantrasyonunda buna elik eden bir azalma olur. Azalan Halamid(Chloramine-T) konsantrasyonlarna sabit bir boya konsantrasyonu eklendiinde, boya konsantrasyonunda bir art ve bir oranArtan STV konsantrasyonu ile ilgili lmaks’ta absorbans art gözlenir. Spektrofotometrik olarak belirlenebilen boyalarn üst limitlerini tespit etmek için ön deneyler yapld ve metil portakal için 5.0 ve 20.0 µg / mL olarak bulundu. ve srasyla indigo carmine. 5,0 µg / mL’lik bir Halamid(Chloramine-T) konsantrasyonunun, 5,0 µg / mL metil turuncunun krmz rengini geri döndürülemez bir ekilde yok ettii görülürken, 22,5 µg / mL indigo karmin nedeniyle mavi rengi beyazlatmak için 20,0 µg / mL Halamid(Chloramine-T) gerekmitir. Bu nedenle, farkl miktarlarda STV, yöntem A’da 1 mL 50,0 µg / mL Halamid(Chloramine-T) ile ve B yönteminde 1 mL 225,0 µg / mL Halamid(Chloramine-T) ile reaksiyona sokuldu ve ardndan ilgili prosedürler altnda açkland gibi kalnt oksidan belirlendi. hem STV’nin oksidasyonu hem de Halamid(Chloramine-T) ile boyann aartlmas, hidroklorik asit ortamnn ideal olduu bulunmutur. Her iki yöntemde de 10 dakikada tamamlanan ve ayn miktarda olan oksidasyon adm için, yöntem A için bir mL 5 M hidroklorik asit ve yöntem B için 2 mL 2 M HCl, toplam hacimde ~ 4-5 mL yeterliydi. boyann tahmini için% 100 asit kullanlmtr. 10 dakikalk temas süresi kritik deildir ve 30 dakikaya kadar herhangi bir gecikmenin absorbans üzerinde hiçbir etkisi yoktur. Her iki boya renginin absorbans, reaksiyon ürünü varlnda birkaç saat stabildi. Halamid(Chloramine-T), titrimetrik bir reaktif ve bir oksitleyici ajandr. Halamid(Chloramine-T) oksitleyici bir biyosittir. P-nitrofenol (PNP) üzerinde özel bir vurgu ile ikame edilmi fenollerin klorlama kinetii, Halamid(Chloramine-T) (CAT) kullanlarak kapsaml bir ekilde incelenmitir. Sulu dimetilformamid (DMF) ve dimetilsülfoksitte (DMSO) reaksiyon, Halamid(Chloramine-T)’ye ikinci dereceden bir bamllk ve DMF durumunda PNP’ye birinci dereceden bir bamllk ve DMSO’da srasyla hafif bir art gösterir. Su ilavesi, hem sulu asetik asit hem de DMF ve DMSO gibi dipolar aprotik çözücülerde oran artrr. Halamid(Chloramine-T)’ye göre reaksiyonun srasnn, pH’a ve fenollerin reaktivitesine bal olduu bulunmutur. Tamponlu asetik asit ortamnda, pH 7’ye kadar Halamid(Chloramine-T)’ye ikinci dereceden bamllk izlendi. 30 ° ¨Dot; 50 ° C aralnda scaklkla hz deiimleri, ikame edilmi tüm fenoller için çalld ve ilgili aktivasyon parametreleri hesapland. Ampirik hz yasas, Halamid(Chloramine-T) kompleks oluturucu PNP’den üretilen türleri içeren bir mekanizma ile açklanr. Protonlanm Halamid(Chloramine-T) ve dikloramin T (DCT) reaksiyon ortamna bal olarak önemli kabul edilir. Tuzlarn, pH’n, yapsal deiikliklerin ve çözücü bamllnn etkisi, önerilen mekanizma tarafndan açklanmtr. Fenolün oksijeni üzerinde pozitif klorun saldrs, tercih edilen saldr eklidir.