2-ETHYLHEXYL ACRYLATE (2-ETLHEKSL AKRLAT)

2-ETHYLHEXYL ACRYLATE (2-ETLHEKSL AKRLAT)

2-ETHYLHEXYL ACRYLATE (2-ETLHEKZL AKRLAT)

CAS No. : 103-11-7

EC No. : 203-080-7

Synonyms:

2-ETHYLHEXYL ACRYLATE; 103-11-7; 2-ethylhexyl prop-2-enoate; 2-Propenoic acid, 2-ethylhexyl ester; 2-Ethyl-1-hexyl acrylate; 2-Ethylhexyl 2-propenoate; Acrylic acid, 2-ethylhexyl ester; 2-ETHYLHEXYLACRYLATE; acrylic acid 2-ethylhexyl ester; 1-Hexanol, 2-ethyl-, acrylate; NSC 4803; Mono(2-ethylhexyl) acrylate; CCRIS 3430; HSDB 1121; 2-Ethylhexylester kyseliny akrylove; EINECS 203-080-7; BRN 1765828; AI3-03833; 2-Ethylhexylester kyseliny akrylove [Czech]; 9003-77-4; CHEBI:82465; EINECS 215-330-2; DSSTox_CID_5297; DSSTox_RID_77732; DSSTox_GSID_25297; Q-200277; CAS-103-11-7; 2-Ethylhexyl acrylate, 99+%, stabilized; 2-ethylexyl acrylate; 2-Propenoic acid, 2-ethylhexyl ester, homopolymer; 2-Ethylhexyl acrylate, homopolymer; 1-Hexanol, acrylate; Octyl Acrylate Monomer; 2-ethylhexyl propenoate; 2-Ethylhexanol acrylate; 2EHA; Octyl acrylate (Related); Acrylic acid 2-ethylhexyl; ACMC-209t5l; EC 203-080-7; SCHEMBL14869; KSC175O1R; 2-Ethylhexyl Acrylate Monomer; Ethyl hexyl acrylate (Related); Acrylic acid-2-ethylhexyl ester; ACRYLATES/VA COPOLY- MER; CHEMBL1574328; DTXSID9025297; CTK0H5718; Acrylic Acid Octyl Ester Monomer; NSC4803; LS-89; 2-Ethylhexyl ester of acrylic acid; KS-00000V3D; NSC-4803; 2-Propenoic acid,octylester,branched; Tox21_202053; Tox21_303227; WLN: 4Y2 & 1OV1U1; 5896AF; 2-Etilheksil Akrilat ; Di etil heksil akrilat; 2-etilheksil akrilat; 2-ETLHEKSKAKRLAT; 2-ETLHEXLAKRLAT; 2-ETHYLHEXYLACRYLATE; 2-ETHYL HEXYL ACRYLATE; 2-ETLHEGSL AKRLAT; 2-ETLHEKZL AKRLAT; 2-ETLHEGZL AKRLAT; 2-ETHYLHEXYL ACRYLATE; 103-11-7; 2-ethylhexyl prop-2-enoate; 2-Propenoic acid, 2-ethylhexyl ester; 2-Ethyl-1-hexyl acrylate; 2-Ethylhexyl 2-propenoate; Acrylic acid, 2-ethylhexyl ester; 2-ETHYLHEXYLACRYLATE; acrylic acid 2-ethylhexyl ester; 1-Hexanol, 2-ethyl-, acrylate; NSC 4803; Mono(2-ethylhexyl) acrylate; CCRIS 3430; HSDB 1121; 2-Ethylhexylester kyseliny akrylove; EINECS 203-080-7; BRN 1765828; AI3-03833; 2-Ethylhexylester kyseliny akrylove [Czech]; 9003-77-4; CHEBI:82465; EINECS 215-330-2; DSSTox_CID_5297; DSSTox_RID_77732; DSSTox_GSID_25297; Q-200277; CAS-103-11-7; 2-Ethylhexyl acrylate, 99+%, stabilized; 2-ethylexyl acrylate; 2-Propenoic acid, 2-ethylhexyl ester, homopolymer; 2-Ethylhexyl acrylate, homopolymer; 1-Hexanol, acrylate; Octyl Acrylate Monomer; 2-ethylhexyl propenoate; 2-Ethylhexanol acrylate; 2EHA; Octyl acrylate (Related); Acrylic acid 2-ethylhexyl; ACMC-209t5l; EC 203-080-7; SCHEMBL14869; KSC175O1R; 2-Ethylhexyl Acrylate Monomer; Ethyl hexyl acrylate (Related); Acrylic acid-2-ethylhexyl ester; ACRYLATES/VA COPOLY- MER; CHEMBL1574328; DTXSID9025297; CTK0H5718; Acrylic Acid Octyl Ester Monomer; NSC4803; LS-89; 2-Ethylhexyl ester of acrylic acid; KS-00000V3D; NSC-4803; 2-Propenoic acid,octylester,branched; Tox21_202053; Tox21_303227; WLN: 4Y2 & 1OV1U1; 5896AF; 2-Etilheksil Akrilat ; Di etil heksil akrilat; 2-etilheksil akrilat; 2-ETLHEKSKAKRLAT; 2-ETLHEXLAKRLAT; 2-ETHYLHEXYLACRYLATE; 2-ETHYL HEXYL ACRYLATE; 2-ETLHEGSL AKRLAT; 2-ETLHEKZL AKRLAT; 2-ETLHEGZL AKRLAT; 2-ETHYLHEXYL ACRYLATE; 103-11-7; 2-ethylhexyl prop-2-enoate; 2-Propenoic acid, 2-ethylhexyl ester; 2-Ethyl-1-hexyl acrylate; 2-Ethylhexyl 2-propenoate; Acrylic acid, 2-ethylhexyl ester; 2-ETHYLHEXYLACRYLATE; acrylic acid 2-ethylhexyl ester; 1-Hexanol, 2-ethyl-, acrylate; NSC 4803; Mono(2-ethylhexyl) acrylate; CCRIS 3430; HSDB 1121; 2-Ethylhexylester kyseliny akrylove; EINECS 203-080-7; BRN 1765828; AI3-03833; 2-Ethylhexylester kyseliny akrylove [Czech]; 9003-77-4; CHEBI:82465; EINECS 215-330-2; DSSTox_CID_5297; DSSTox_RID_77732; DSSTox_GSID_25297; Q-200277; CAS-103-11-7; 2-Ethylhexyl acrylate, 99+%, stabilized; 2-ethylexyl acrylate; 2-Propenoic acid, 2-ethylhexyl ester, homopolymer; 2-Ethylhexyl acrylate, homopolymer; 1-Hexanol, acrylate; Octyl Acrylate Monomer; 2-ethylhexyl propenoate; 2-Ethylhexanol acrylate; 2EHA; Octyl acrylate (Related); Acrylic acid 2-ethylhexyl; ACMC-209t5l; EC 203-080-7; SCHEMBL14869; KSC175O1R; 2-Ethylhexyl Acrylate Monomer; Ethyl hexyl acrylate (Related); Acrylic acid-2-ethylhexyl ester; ACRYLATES/VA COPOLY- MER; CHEMBL1574328; DTXSID9025297; CTK0H5718; Acrylic Acid Octyl Ester Monomer; NSC4803; LS-89; 2-Ethylhexyl ester of acrylic acid; KS-00000V3D; NSC-4803; 2-Propenoic acid,octylester,branched; Tox21_202053; Tox21_303227; WLN: 4Y2 & 1OV1U1; 5896AF; 2-Etilheksil Akrilat ; Di etil heksil akrilat; 2-etilheksil akrilat; 2-ETLHEKSKAKRLAT; 2-ETLHEXLAKRLAT; 2-ETHYLHEXYLACRYLATE; 2-ETHYL HEXYL ACRYLATE; 2-ETLHEGSL AKRLAT; 2-ETLHEKZL AKRLAT; 2-ETLHEGZL AKRLAT;

EN

2-ETHYLHEXYL ACRYLATE IUPAC Name 2-ethylhexyl prop-2-enoate

2-ETHYLHEXYL ACRYLATE InChI InChI=1S/C11H20O2/c1-4-7-8-10(5-2)9-13-11(12)6-3/h6,10H,3-5,7-9H2,1-2H3

2-ETHYLHEXYL ACRYLATE InChI Key GOXQRTZXKQZDDN-UHFFFAOYSA-N

2-ETHYLHEXYL ACRYLATE Canonical SMILES CCCCC(CC)COC(=O)C=C

2-ETHYLHEXYL ACRYLATE Molecular Formula C11H20O2

2-ETHYLHEXYL ACRYLATE CAS 103-11-7

2-ETHYLHEXYL ACRYLATE Deprecated CAS 126830-02-2, 78733-32-1, 84948-57-2, 93460-77-6, 1329996-89-5, 1453489-97-8, 45016-65-7

2-ETHYLHEXYL ACRYLATE European Community (EC) Number 203-080-7

2-ETHYLHEXYL ACRYLATE ICSC Number 0478 

2-ETHYLHEXYL ACRYLATE NSC Number 4803

2-ETHYLHEXYL ACRYLATE RTECS Number AT0855000

2-ETHYLHEXYL ACRYLATE UN Number 1993

2-ETHYLHEXYL ACRYLATE Physical Description Liquid

2-ETHYLHEXYL ACRYLATE Color/Form Colorless liquid

2-ETHYLHEXYL ACRYLATE Odor Pleasant

2-ETHYLHEXYL ACRYLATE Boiling Point 417 to 424 °F at 760 mm Hg (NTP, 1992)

2-ETHYLHEXYL ACRYLATE Melting Point -130 °F (NTP, 1992)

2-ETHYLHEXYL ACRYLATE Flash Point 180 °F (NTP, 1992)

2-ETHYLHEXYL ACRYLATE Solubility less than 1 mg/mL at 72° F (NTP, 1992)

2-ETHYLHEXYL ACRYLATE Density 0.885 at 68 °F (USCG, 1999)

2-ETHYLHEXYL ACRYLATE LogP log Kow = 4.09 /Estimated/

2-ETHYLHEXYL ACRYLATE Molecular Weight 184.27 g/mol

2-ETHYLHEXYL ACRYLATE XLogP3-AA 3.8

2-ETHYLHEXYL ACRYLATE Hydrogen Bond Donor Count 0

2-ETHYLHEXYL ACRYLATE Hydrogen Bond Acceptor Count 2

2-ETHYLHEXYL ACRYLATE Rotatable Bond Count 8

2-ETHYLHEXYL ACRYLATE Exact Mass 184.14633 g/mol

2-ETHYLHEXYL ACRYLATE Monoisotopic Mass 184.14633 g/mol

2-ETHYLHEXYL ACRYLATE Topological Polar Surface Area 26.3 Ų

2-ETHYLHEXYL ACRYLATE Heavy Atom Count 13

2-ETHYLHEXYL ACRYLATE Formal Charge 0

2-ETHYLHEXYL ACRYLATE Complexity 152

2-ETHYLHEXYL ACRYLATE Isotope Atom Count 0

2-ETHYLHEXYL ACRYLATE Defined Atom Stereocenter Count 0

2-ETHYLHEXYL ACRYLATE Undefined Atom Stereocenter Count 1

2-ETHYLHEXYL ACRYLATE Defined Bond Stereocenter Count 0

2-ETHYLHEXYL ACRYLATE Undefined Bond Stereocenter Count 0

2-ETHYLHEXYL ACRYLATE Covalently-Bonded Unit Count 1

2-ETHYLHEXYL ACRYLATE Compound Is Canonicalized Yes

Racemic 2-ethylhexyl acrylate can be prepared with a high yield by esterification of acrylic acid with racemic 2-ethylhexanol in the presence of hydroquinone as a polymerization inhibitor and a strong acid such as methanesulfonic acid by reactive distillation using toluene as an azeotroping agent.[2]2-Ethylhexyl acrylate polymerizes easily. The polymerization can be initiated by light, peroxides, heat, or contaminants. It can react violently when combined with strong oxidants and can form explosive mixtures with air at temperatures above 82 °C (180 °F). The chemical, physical, and toxicological properties, however, can be greatly modified by additives or stabilizers.2-Ethylhexyl acrylate and butyl acrylate are the major base monomers for the preparation of acrylate adhesives. 2-Ethylhexyl acrylate can react by free-radical polymerization to form macromolecules having a molecular weight of up to 200,000 g/mol. Other monomers such as vinyl acetate, methyl acrylate, and styrene may be copolymerized to modify the properties of the resulting polymer.[3]2-Ethylhexyl acrylate can undergo free radical solution polymerization to yield its polymer. [1] It can form a series of copolymers via atom transfer radical copolymerization. [6] A study reports the emulsion terpolymerization of the product with styrene, methacrylic acid. [7] 2-ethylhexyl acrylate (EHA) is one of the constituents of acrylic polymeric latex. [2]It can undergo free-radical solution polymerization.[1] EHA is known to undergo free radical emulsion co- polymerization with methyl methacrylate (MMA) to form pressure-sensitive adhesives. [3][4] It may also form copolymers with acrylonitrile and acrylamide. [5]2-Ethylhexyl acrylate (HA) is the ester of acrylic acid and 2-ethyl hexanol. It is used as a raw material to make adhesives, coatings, construction materials, acrylic rubber, and emulsions.2-Ethylhexyl acrylate (HA) is the ester of acrylic acid and 2-ethyl hexanol.Our 2-ethylhexyl acrylate has very low-level impurities and may be used as a raw material for a wide variety of chemicals.2-Ethylhexyl acrylate (HA) is used as a raw material to make adhesives, coatings, construction materials, acrylic rubber, and emulsions.2-Ethylhexyl acrylate is produced from 2-ethyl hexanol and acrylic acid by catalytic dehydratisation in a continuous process. The spent lye of the aqueous work-up is treated in a waste water treatment plant. 2-Ethylhexyl acrylate is used as a monomer in the chemical industry for the production of polymers and copolymers, which are mainly processed further to aqueous polymer dispersions. The polymers and polymer dispersions are used in adhesives and as binders for paints. Other applications include coatings raw materials and uses in the plastics and textiles industries. In addition, 2-ethylhexyl acrylate is used as a monomer in construction-industry chemicals(e.g. floor coatings, road-marking substances) in concentrations between 0.1-21%. Releases of 2-ethylhexyl acrylate into the environment are expected to occur mainly during production and processing with waste water and exhaust gases.Based on the physical chemical properties of 2-ethylhexyl acrylate, the atmosphere is the main target compartment for distribution and only small amounts remain in the hydrosphere. Data on biotic or abiotic effects in the air compartment are not available. Because of the short half-life of 2-ethylhexyl acrylate in the atmosphere (about 19 hours) adverse effects are not to be expected. To evaluate whether the substance may cause toxic effects if accumulated in higher organisms through the food chain the classification on the basis of mammalian toxicity data can be used. 2-Ethylhexyl acrylate is not classified as Very Toxic or Toxic or Harmful and there are no adequate data from dietary toxicity tests which can be used for the determination of a PNECoral. Therefore a quantitative assessment of secondary poisoning can not be performed but improvement of the data basis is not of high priority for 2-ethylhexyl acrylate. A site specific release estimation representing a worst case situation for production,processing and use of 2-ethylhexyl acrylate was used to calculate the atmospheric deposition and the resulting concentration in the soil porewater in the vicinity of that site. A site specific release estimation representing a worst case situation for production,processing and use of 2-ethylhexyl acrylate was used to calculate the atmospheric deposition and the resulting concentration in the soil porewater in the vicinity of that site. 2-Ethyl Hexyl Acrylate is produced by reacting 2-ethyl hexanol and acrylic acid in a dehydratation process that acts as the catalyst. 2-Ethyl Hexyl Acrylate will react with oxidising agents such as alkalis and will polymerise when heated.  Polymerisation is inhibited by hydroquinone.2-Ethyl Hexyl Acrylate  is used in the chemical manufacturing industry for the production of homopolymers and co-polymers emulsion.  It is used as a co-polymer for caulks, paint coatings, pressure sensitive adhesives (PSA) and sealants, leather finishing, paint additives, textiles and paper coatings. 2-ethyl hexyl acrylate also known as 2-Propenoic acid, 2-ethylhexyl ester; is an acrylate monomer with a molecular formula of C11H20O2, CAS: 103-11-7.  It is a clear liquid which is not soluble in water and completely soluble in alcohols and ethers.  It has a flashpoint between 75 – 90°C and has a characteristic acrylic odour.2-Ethylhexyl Acrylate (2-EHA ) is a highly versatile building block that readily copolymerizes with a wide variety of other acrylic and vinyl monomers to tailor specific high molecular weight copolymer properties for a diverse range of non-rigid applications.As a higher alkyl acrylate comonomer, 2-EHA imparts a glass transition temperature that is well below room temperature (homopolymer Tg is – 65 °C), flexibility and elasticity, and a hydrophobic nature. Unique features contributed to copolymer compositions include low temperature flexibility, water resistance, good weathering characteristics, and UV (sunlight) resistance. Primary applications that take advantage of these characteristics include multiple adhesives, especially pressure-sensitive adhesives (PSA), paint & coatings, caulks & sealants, textile & paper finishes, and printing inks.Because 2-EHA contributes to clarity, toughness, light & weather resistance, and chemical resistance, manufacturers can use acrylic copolymers containing 2-EHA in interior, exterior, basecoat and topcoat paint & coating formulations, and other related products.New areas of technical application for 2-EHA are in the homopolymer, poly(2-ethylhexyl acrylate), used as a plasticizer material for surface coatings, film, sheeting, and pressure-sensitive adhesives and tapes. As a plasticizer incorporated into PSAs, it results in an increase in peel strength, tack, and at the same time can improve removability. 2-EHA is used in superabsorbent copolymers to produce fast swelling and highly porous hydrogels for diapers and hygiene products.2-Ethylhexyl acrylate is a key monomer in a wide range of copolymer compositions. Free-radical polymerization techniques afford high monomer conversions and very high macromolecule molecular weights (>200,000). The ease of handling and co-polymerization of 2-EHA allow for use in emulsion, solvent, suspension and bulk polymerizations.BASF 2-Ethylhexyl Acrylate 2-Ethylhexyl acrylate 98% 2-Ethylhexyl acrylate forms homopolymers and copolymers. Copolymers of 2-Ethylhexyl acrylate can be prepared with acrylic acid and its salts, amides and esters, and with methacrylates, acrylonitrile, maleic acid esters, vinyl acetate, vinyl chloride, vinylidene chloride, styrene, butadiene, unsaturated polyesters and drying oils, etc. 2-Ethylhexyl acrylate is also a very useful feedstock for chemical syntheses, because it readily undergoes addition reactions with a wide variety of organic and inorganic compoundsToxicological Evaluation and Limit Values for 2-Ethylhexyl acrylate, Propylene carbonate, Quaternary ammonium compounds, Triglycidyl isocyanurate, and Tripropyleneglycol diacrylateDirect, acid-catalysed esterification of acrylic acid with 2-ethylhexanol is the principal method for the manufacture of 2-ethylhexyl acrylate. A polymerisation inhibitor is added. (IARC 1994).The major current use of 2-ethylhexyl acrylate is in acrylic pressure-sensitive adhesives. An adhesive for general purpose tape typically contains about 75% 2-ethylhexyl acrylate. Other uses of 2-ethylhexyl acrylate is in the production of plastics, latex, paints, textile and leather finishes, coatings for paper and industrial metal finishing. (HSDB 1999, IARC 1994).In Denmark, the principal use of 2-ethylhexyl acrylate is in UV curable inks, lacquers and varnishes. Emission occurs in the form of aerosols.2-Ethylhexyl acrylate is not known to occur as a natural compound. It may be released into the environment in fugitive and stack emissions or in wastewater during its production and use. (HSDB 1999, IARC 1994).2-Ethylhexyl acrylate is expected to exist almost entirely in the vapour phase based on its vapour pressure. It may photolyse in sunlight. It will react with photochemically produced hydroxyl radicals and ozone with an estimated half-life of 10.3 hours. (HSDB 1999).2-Ethylhexyl acrylate is not expected to adsorb to sediment or suspended particulate matter. It may hydrolyse, especially in alkaline waters based upon hydrolysis data for the structurally similar ethyl acrylate. It may photolyse in sunlight. It may biodegrade based upon the biodegradability of butyl acrylate and ethyl acrylate. It will significantly volatise from water with an estimated half-life of between 7.3 hours and 2.7 days. (HSDB 1999).2-Ethylhexyl acrylate is expected to exhibit moderate mobility in soil and, therefore, it may leach to groundwater. It may hydrolyse, especially in alkaline soils based upon hydrolysis data for the structurally similar ethyl acrylate. It may biodegrade based upon the biodegradability of butyl acrylate. It may volatilise from near surface soil and other surfaces. (HSDB 1999).According to HSDB (1999) 2-Ethylhexyl acrylate is not expected to bioconcentrate in aquatic organisms. However BUA (1994) is stating that considerable bioaccumulation is to be expected.The most probable route of human exposure of 2-ethylhexyl acrylate is by inhalation of contaminated air especially at plants where it is manufactured and used. Workers also may be exposed dermally during spills or leaks. (Samimi & Falbo 1982).In one study male Wistar rats were administrated an intravenous dose of 10 mg/kg bw of (14C)-2-ethylhexyl acrylate labelled on the vinyl carbons (Gut et al. 1988). In another study male Wistar rats were administrated an intravenous dose of 10 mg/kg bw or 50 mg/kg bw of (14C)-2-ethylhexyl acrylate (Cikrt et al. 1986). The highest concentrations of radioactivity in tissues was found in kidney, liver, brain, thymus and spleen.2-Ethylhexyl acrylate is believed to undergo carboxylesterase-catalysed hydrolysis to 2-ethylhexanol and acrylic acid, like other acrylate esters (Cikrt et al. 1986, Miller et al. 1981 – quoted from IARC 1994).2-Ethylhexyl acrylate to a minor extent reacts with non-protein SH groups in for instance glutathione causing depletion of the non-protein SH groups and excretion of thioethers in urine as described in the following studies:Male Wistar rats exposed by 6 hours inhalation to 2-ethylhexyl acrylate in concentrations from 250 to 4800 mg/m3 over 24 hours excreted thioethers in urine in a dose dependent manner decreasing from 8.0 to 3.0% (at 1000 mg/m3) of the dose of 2-ethylhexyl acrylate indicating saturable metabolism along this pathway. Dose related depletion of non-protein SH groups in blood, liver and brain was seen at concentrations of and above 2400 mg/m3. (Vodicka et al. 1990).When male Wistar rats were administrated an intraperitoneal dose of 10 mg/kg bw of (14C)-2-ethylhexyl acrylate labelled on the vinyl carbons 2% of the dose was found as thioethers in the urine (Gut et al. 1988).The principal eliminated metabolite in expired air was carbon dioxide in two studies in male Wistar rats given an intraperitoneal or intravenous dose of (14C)-2-ethylhexyl acrylate (Gut et al. 1988, Sapota 1988).When 2-ethylhexyl acrylate and its metabolite acrylic acid reacts with the reduced form of glutathion (GSH), mercapturic acids can be formed (Cikrt et al. 1986).2-Ethylhexyl acrylate is believed to undergo carboxylesterase-catalysed hydrolysis to 2-ethylhexanol and acrylic acid, like other acrylate esters (Cikrt et al. 1986, Miller et al. 1981 – quoted from IARC 1994).2-Ethylhexyl acrylate to a minor extent reacts with non-protein SH groups in for instance glutathione causing depletion of the non-protein SH groups and excretion of thioethers in urine as described in the following studies:Male Wistar rats exposed by 6 hours inhalation to 2-ethylhexyl acrylate in concentrations from 250 to 4800 mg/m3 over 24 hours excreted thioethers in urine in a dose dependent manner decreasing from 8.0 to 3.0% (at 1000 mg/m3) of the dose of 2-ethylhexyl acrylate indicating saturable metabolism along this pathway. Dose related depletion of non-protein SH groups in blood, liver and brain was seen at concentrations of and above 2400 mg/m3. (Vodicka et al. 1990).When male Wistar rats were administrated an intraperitoneal dose of 10 mg/kg bw of (14C)-2-ethylhexyl acrylate labelled on the vinyl carbons 2% of the dose was found as thioethers in the urine (Gut et al. 1988).The principal eliminated metabolite in expired air was carbon dioxide in two studies in male Wistar rats given an intraperitoneal or intravenous dose of (14C)-2-ethylhexyl acrylate (Gut et al. 1988, Sapota 1988).When 2-ethylhexyl acrylate and its metabolite acrylic acid reacts with the reduced form of glutathion (GSH), mercapturic acids can be formed (Cikrt et al. 1986).Male Wistar rats were administrated an intravenous dose of 10 mg/kg bw or 50 mg/kg bw of (14C)-2-ethylhexyl acrylate. Biliary excretion of radioactivity was followed in 1-3 hour intervals within the first 24 hours after administration. A significant increase in bile flow (243%) was observed. In the 24-hours 2.2% of the dose was eliminated via bile at both doses, most of it (83%) during the first 3 hours. (Cikrt et al. 1986).Seven persons have developed allergic contact dermatitis due to an acrylic based adhesive tape. Patch-testing revealed that all persons reacted to 2-ethylhexyl acrylate. Five of the persons were further tested for cross-sensitisation patterns. They all reacted to 2-ethylbutylacrylate and some of them reacted to other acrylates as well. (Jordan 1975).In Finland, 5 cases of occupational contact urticaria caused by 2-ethylhexyl acrylate has been reported from 1990 to 1994 (Kanerva et al. 1996 – quoted from Toxline pre1981-1999).When rats were exposed to a saturated atmosphere (about 1400 mg/m3) of 2-ethylhexyl acrylate for 8 hours no mortality occurred (BASF 1958 – quoted from IUCLID 1996).Alderley Park rats (2 animals of each sex per group) were exposed to 2-ethylhexyl acrylate in ethanol at 375 and 1000 mg/m3 6 hours a day, 5 days per week for 2½ week. A reduced body weight gain, lethargy, and dyspnoea were observed in high-dose animals. No changes in blood, urine and pathology were observed. Low-dose animals showed no toxic signs. (Gage 1970 – quoted from IUCLID 1996).The reported oral LD50-values for 2-ethylhexyl acrylate ranged from 4.4 to 12.8 g/kg for rats (5 values reported), and from 4.4 to greater than 5.0 g/kg for mice (2 values reported). Rabbits have an oral LD50-value greater than 3.5 g/kg and the value for cats is greater than 1.8 g/kg (1 value reported for each species). (Studies quoted in IUCLID 1996, Clayton & Clayton 1994, DPIMR 1981, BUA 1994).Rabbits (1 animal per sex) were fed 2-ethylhexyl acrylate as a 10% emulsion through a tube at a dose of 1774 mg/kg for 6 days (male) or 8 days (female). Four female rabbits were fed a dose of 887 mg/kg for 10 days. The high-dose animals died after 6 or 8 days. A reduced body weight gain, lack of desire to eat, and weak muscle tonus were observed and the gastric mucosa and kidneys were damaged. Low-dose animals only showed momentary lack of desire to eat and a slightly reduced body weight gain. (BASF 1960 – quoted from BUA 1994).Female Dunkin Hartley outbred guinea pigs were induced with intradermal injections of 2-ethylhexyl acrylate in concentrations of 0.5 M or 0.17 M in Freund´s complete adjuvant three times during 9 days. Sensitisation was observed when the animals were challenged at day 21, 35 and 49 with 1 M 2-ethylhexyl acrylate applied epicutaneously. At an induction concentration of 0.5 M 6-11 out of 16 animals were sensitised. At an induction concentration of 0.17 M 11-13 out of 16 animals were sensitised. Four control animals were sensitised (3 at day 35 and 1 at day 49). Cross reaction was seen with ethyl acrylate, n-butyl acrylate and hexyl acrylate. (Waegemaekers & van der Walle 1983).Guinea pigs were induced with 0.1% (w/v) 2-ethylhexyl acrylate applied epicutaneous or intracutaneous 3 times a week for 3 weeks. Sensitisation was observed when the animals were challenged at day 11 after the induction with the same concentration of 2-ethylhexyl acrylate as used for the induction. For the epicutaneous test, 10 out of 10 animals were sensitised. For the intracutaneous test, 7 out of 10 animals were sensitised. (Hunter et al. 1966 – quoted from Nordisk Ministerråd 1991).In the Polak method, 6 Hartley outbred guinea pigs of either sex were induced with 1 mg 2-ethylhexyl acrylate in Freund´s complete adjuvant applied as injections in the footpads and the neck. Sensitisation was observed when the animals were challenged at day 7 after the induction with 1% or 5% 2-ethylhexyl acrylate. (Parker & Turk 1983).There was an apparent increase in the frequency of chronic nephritis in C3H/HeJ mice (68%) treated three times a week for their lifetime with 20 mg 75% (v/v) 2-ethylhexyl acrylate in acetone applied to clipped dorsal skin compared to the negative control (15%). Survival was not affected by the treatment with 2-ethylhexyl acrylate. (DePass et al. 1985).Male NMRI and C3H/HeJ mice (10 animals per group) exposed to doses of 25ml 21% or 86.5% 2-ethylhexyl acrylate in acetone 3 times a week for 3 months exhibited skin irritation. The NMRI mice were less sensitive than the C3H/HeJ mice. No skin irritation were observed for the NMRI mice given 21% 2-ethylhexyl acrylate. (BASF 1985 – quoted from IUCLID 1996).In long term (2 years or for life) carcinogenicity studies with 2-ethylhexyl acrylate applied to NMRI or C3H/HeJ mice (80 animals per group) 3 times a week, skin irritation (scaling, scabbing, hyperkeratosis, hyperplasia, crust formation and ulceration) was observed. Survival were not affected by the treatment with 2-ethylhexyl acrylate and no systemic effects were seen. (Mellert et al. 1994, Wenzel-Hartung et al. 1989). The lowest dose administered to the C3H/HeJ mice was 25 ml of a 2.5% (w/w) solution of 2-ethylhexyl acrylate in acetone. Skin irritation was observed at this dose, however, after the 11th week of treatment, these lesions were reversible. One group of C3H/HeJ mice was treated with a 43% solution for 24 weeks and thereafter observed for lifetime. Skin lesions were reversible in the 43% group immediately after treatment was stopped. For the higher doses (21% and 86.5%) further skin lesions developed. (Wenzel-Hartung et al. 1989).Male and female New Zealand white rabbits (2 or 1 animals of each sex) exposed to 1 ml per day of 2-ethylhexyl acrylate for 3 or 12 days developed skin inflammation. After 12 days necroses and ulcerations were also observed. (Hunter et al. 1981 – quoted from IUCLID 1996).Male and female guinea pigs (5 animals of each sex) exposed to 0.5 ml per day of 2-ethylhexyl acrylate for 12 days developed skin inflammation, necroses and ulcerations. The lesions were worse than the lesions seen in rabbits exposed to the double dose of 2-ethylhexyl acrylate. (Hunter et al. 1981 – quoted from IUCLID 1996).2-Ethylhexyl acrylate was not mutagenic in 4 strains (TA98, TA100, TA1535, and TA1537) of Salmonella typhimurium in an Ames test with or without metabolic activation systems (Zeiger et al. 1985).2-Ethylhexyl acrylate tested in cultured L5178Y mouse lymphoma cells without exogenous activation produced an equivocal result for an increased mutant frequency as well as for induced aberrations. No increase in the number of micronuclei was seen. (Dearfield et al. 1989).In another experiment the mutation frequency was up to 4.6 times greater than in controls for the highest dose levels of 2-ethylhexyl acrylate added to cultured L5178Y mouse lymphoma cells with metabolic activation. No reproducible increase in mutation frequency was seen without the metabolic activation. (Litton Bionetics 1984 – quoted from HSDB 1999).2-Ethylhexyl acrylate did not induce a dose-related increase in the hgprt mutant frequency in either the suspension or monolayer assay in Chinese hamster ovary cells (Moore et al. 1991).A cell transformation assay in C3H-10T1/2 cells tested negative with 2-ethylhexyl acrylate (BASF 1982 – quoted from IUCLID 1996).The sister chromatid exchange assay in CHO cells with and without metabolic activation was slightly positive when tested with 2-ethylhexyl acrylate with metabolic activation (ambiguous result) (BASF 1980 – quoted from IUCLID 1996).Unscheduled DNA synthesis in primary rat hepatocytes was slightly increased when tested with 2-ethylhexyl acrylate (ambiguous result) (BASF 1980 – quoted from IUCLID 1996).No chromosome aberrations were observed when mice were given an oral dose of 2.5 g/kg once a day for 1 or 5 days in an in vivo cytogenetic assay (BASF- quoted in IUCLID 1996).In a 2-year carcinogenicity study 25 ml of a 21.5, 43 or 85% (w/w) solution of 2-ethylhexyl acrylate in acetone was applied epicutaneously to the clipped dorsal skin of male NMRI mice (80 per group) three times a week. After about 7 months half of each group was rested for treatment for 2 months and then treated with a promoter for 20 weeks. None of the mice treated with 2-ethylhexyl acrylate alone developed a skin tumour at the application site. One squamous cell papilloma occurred in each of the groups treated with 2-ethylhexyl acrylate and the promoter. Squamous cell carcinomas were observed only in the positive control groups (exposed to 0.015 % benzo[a]pyrene alone or in combination with promoter). (Mellert et al. 1994).In a lifetime carcinogenicity study 25 ml of a 2.5, 21 or 86.5% (w/w) solution of 2-ethylhexyl acrylate in acetone was applied epicutaneously to the clipped dorsal skin of male C3H/HeJ mice (80 per group) three times a week. Another group was treated with a 43% solution for 24 weeks and thereafter observed for lifetime. Only in the 86.5% and 21% test groups showing chronic irritative skin damage there was a high incidence of neoplastic skin lesions (total of 15 papillomas, 36 carcinomas, and 16 melanomas) with no dose dependency. In contrast, no skin tumours were found in the negative control groups, in the group treated with 2.5% 2-ethylhexyl acrylate for lifetime or in the group treated with 43% 2-ethylhexyl acrylate for about 6 months and then observed for lifetime. (Wenzel-Hartung et al. 1989).In a lifetime carcinogenicity study 20 mg of a 75% (v/v) solution of 2-ethylhexyl acrylate in acetone was applied epicutaneously to the clipped dorsal skin of 40 male C3H/HeJ mice three times a week. The concentration was chosen as the highest concentration that caused neither grossly observable irritation nor reduced weight gain in a preliminary 2-week study. Two animals had squamous cell carcinomas and four additional animals had squamous cell papillomas all on the treated skin. (DePass et al. 1985).2-Ethylhexyl acrylate is a colourless liquid with a sharp, musty odour. Its solubility in water is low (0.1g/l). Its vapour pressure is 0.14 mmHg. The odour threshold in air is 0.55-1.36 mg/m3.In Denmark, the principal use of 2-ethylhexyl acrylate is in UV curable inks, lacquers and varnishes.2-Ethylhexyl acrylate is not known to occur as a natural compound. It may be released into the environment in fugitive and stack emissions or in wastewater during its production and use.If released to the atmosphere, 2-ethylhexyl acrylate will react with photochemically produced hydroxyl radicals and ozone with an estimated half-life of 10.3 hours. It may also photolyse in sunlight.If released to soil and water, 2-ethylhexyl acrylate may biodegrade and it may hydrolyse, especially in an alkaline environment. 2-Ethylhexyl acrylate is not expected to adsorb to sediment or suspended particulate matter in water. It is expected to exhibit moderate mobility in soil. 2-Ethylhexyl acrylate will significantly volatise from water and near surface soil with an estimated half-life of between 7.3 hours and 2.7 days.In the rat 2-ethylhexyl acrylate is readily absorbed through the gastrointestinal tract and after intraperitoneal application. The plasma radioactivity concentration peaked at 2-3 hours. Following absorption 2-ethylhexyl acrylate is distributed to various organs with the highest concentration occurring in the liver and kidney. 2-Ethylhexyl acrylate is rapidly metabolised and excreted. At high doses (100 mg/kg bw) the decline in concentration in the tissues was slower with levels remaining almost constant for 72 hours in adipose tissue. 2-Ethylhexyl acrylate is believed to undergo carboxylesterase-catalysed hydrolysis to alcohol and acrylic acid, like other acrylate esters. 2-Ethylhexyl acrylate to a minor extent reacts with non-protein SH groups resulting in thioethers and mercapturic acids being excreted in the urine and/or bile. The major route of excretion is the lungs (50-75%) followed by urine (7-41%) and faeces (0.01-3 %). The metabolite in the lungs is CO2.Seven cases of allergic contact dermatitis due to an acrylic based adhesive tape have been reported. Patch-testing revealed that all persons reacted to 2-ethylhexyl acrylate. No cases have been reported of respiratory sensitisation. In Finland 5 people have got contact urticaria due to 2-ethylhexyl acrylate.Single peroral, dermal or inhalatory administration of 2-ethylhexyl acrylate each proved to be only slightly toxic (LC50-value for mice is greater than 7700 mg/m3; oral LD50-values ranged from 1.8 to 12.8 g/kg for different species; and dermal LD50-values ranged from 7.5 to 16 g/kg for different species).When rats were inhaling about 1400 mg/m3 of 2-ethylhexyl acrylate for 8 hours no mortality occurred.A reduced body weight gain, lethargy, and dyspnoea were observed in Alderley Park rats inhaling 2-ethylhexyl acrylate at 1000 mg/m3 6 hours a day, 5 days per week for 2½ week. Animals inhaling 375 mg/m3 for the same exposure period showed no toxic signs.Skin sensitisation was observed in challenged guinea pigs that had been induced with intradermal injections of 2-ethylhexyl acrylate in concentrations of 0.5 M or 0.17 M in Freund´s complete adjuvant three times during 9 days; that had been induced with epicutaneous or intracutaneous application of 2-ethylhexyl acrylate in concentrations of 0.1% (w/v) 3 times a week for 3 weeks; or that in the Polak method had been induced with 1 mg 2-ethylhexyl acrylate in Freund´s complete adjuvant applied as injections in the footpads and the neck.Repeated application to the skin of mice, rabbits and guinea pigs caused skin irritation and subsequent degeneration of the treated areas. C3H mice were more sensitive than NMRI mice. In a lifetime study with 2-ethylhexyl acrylate applied to mice 3 times a week skin irritation was seen. The lowest dose administered was 25 ml of a 2.5% (w/w) solution of 2-ethylhexyl acrylate in acetone. Skin irritation was observed at this dose, however, after the 11th week of treatment, these lesions were reversible. For the higher doses (21% and 86.5%) further skin lesions developed.In one study 2-ethylhexyl acrylate was irritant to the rabbit eye but in another one it was non-irritating.The olfactory epithelium of the nasal mucosa was degenerated when Wistar rats inhaled 2-ethylhexyl acrylate at 225 and 750 mg/m3 6 hours a day, 5 days per week for 90 days. A reduced body weight gain, lethargy and reduced levels for albumin were also observed at these doses. Animals inhaling 75 mg/m3 for the same exposure period showed no toxic signs.An apparent increase in the frequency of chronic nephritis was seen in male C3H/HeJ mice treated three times a week for their lifetime with 20 mg 75% (v/v) 2-ethylhexyl acrylate in acetone applied to clipped dorsal skin.

TR

2-ETLHEKSL AKRLAT IUPAC Ad 2-etilheksil prop-2-enoat

2-ETLHEKSL AKRLAT InChI InChI = 1S / C11H20O2 / c1-4-7-8-10 (5-2) 9-13-11 (12) 6-3 / h6,10H, 3-5,7-9H2,1 -2H3

2-ETLHEKSL AKRLAT InChI Anahtar GOXQRTZXKQZDDN-UHFFFAOYSA-N

2-ETLHEKSL AKRLAT Kanonik Gülüler CCCCC (CC) COC (= O) C = C

2-ETLHEKSL AKRLAT Moleküler Formül C11H20O2

2-ETLHEKSL AKRLAT CAS 103-11-7

2-ETLHEKSL AKRLAT Kullanmdan Kaldrlm CAS 126830-02-2, 78733-32-1, 84948-57-2, 93460-77-6, 1329996-89-5, 1453489-97-8, 45016-65-7

2-ETLHEKSL AKRLAT Avrupa Topluluu (EC) Numaras 203-080-7

2-ETLHEKSL AKRLAT ICSC Numaras 0478

2-ETLHEKSL AKRLAT NSC Numaras 4803

2-ETLHEKSL AKRLAT RTECS Numaras AT0855000

2-ETLHEKSL AKRLAT BM Numaras 1993

2-ETLHEKSL AKRLAT Fiziksel Tanm Sv

2-ETLHEKSL AKRLAT Renk / Form Renksiz sv

2-ETLHEKSL AKRLAT Koku Ho

2-ETLHEKSL AKRLAT Kaynama Noktas 760 mm Hg’de 417 ila 424 ° F (NTP, 1992)

2-ETLHEKSL AKRLAT Erime Noktas -130 ° F (NTP, 1992)

2-ETLHEKSL AKRLAT Parlama Noktas 180 ° F (NTP, 1992)

2-ETLHEKSL AKRLAT Çözünürlük 72 ° F’de 1 mg / mL’den az (NTP, 1992)

2-ETLHEKSL AKRLAT Younluk 68 ° F’de 0.885 (USCG, 1999)

2-ETLHEKSL AKRLAT LogP log Kow = 4.09 / Tahmini /

2-ETLHEKSL AKRLAT Moleküler Arlk 184,27 g / mol

2-ETLHEKSL AKRLAT XLogP3-AA 3.8

2-ETLHEKSL AKRLAT Hidrojen Ba Donör Says 0

2-ETLHEKSL AKRLAT Hidrojen Ba Alcs Says 2

2-ETLHEKSL AKRLAT Dönebilen Tahvil Says 8

2-ETLHEKSL AKRLAT Tam Kütle 184.14633 g / mol

2-ETLHEKSL AKRLAT Monoizotopik Kütle 184.14633 g / mol

2-ETLHEKSL AKRLAT Topolojik Polar Yüzey Alan 26,3 Ų

2-ETLHEKSL AKRLAT Ar Atom Says 13

2-ETLHEKSL AKRLAT Resmi Ücret 0

2-ETLHEKSL AKRLAT Karmaklk 152

2-ETLHEKSL AKRLAT zotop Atom Says 0

2-ETLHEKSL AKRLAT Tanml Atom Stereo Merkez Says 0

2-ETLHEKSL AKRLAT Tanmsz Atom Stereocenter Says 1

2-ETLHEKSL AKRLAT Tanml Ba Stereo Merkez Says 0

2-ETLHEKSL AKRLAT Tanmsz Ba Stereo Merkez Says 0

2-ETLHEKSL AKRLAT Kovalent Bal Birim Says 1

2-ETLHEKSL AKRLAT Bileii Kanonikletirilmitir Evet

Rasemik 2-etilheksil akrilat, akrilik asidin, bir polimerizasyon inhibitörü olarak hidrokinon ve metansülfonik asit gibi güçlü bir asit varlnda rasemik 2-etilheksanol ile esterletirilmesi ve azeotropik ajan olarak toluen kullanlarak reaktif damtma yoluyla yüksek verimle hazrlanabilir. [ 2] 2-Etilheksil akrilat kolaylkla polimerize olur. Polimerizasyon, k, peroksitler, s veya kirleticiler tarafndan balatlabilir. Güçlü oksidanlarla birletiinde iddetli reaksiyona girebilir ve 82 ° C’nin (180 ° F) üzerindeki scaklklarda havayla patlayc karmlar oluturabilir. Bununla birlikte kimyasal, fiziksel ve toksikolojik özellikler, katk maddeleri veya stabilizatörler ile büyük ölçüde deitirilebilir. 2-Etilheksil akrilat ve butil akrilat, akrilat yaptrclarn hazrlanmasnda ana baz monomerlerdir. 2-Etilheksil akrilat, 200.000 g / mol’e kadar moleküler arla sahip makromoleküller oluturmak için serbest radikal polimerizasyonu ile reaksiyona girebilir. Vinil asetat, metil akrilat ve stiren gibi dier monomerler, elde edilen polimerin özelliklerini deitirmek için kopolimerize edilebilir. [3] 2-Etilheksil akrilat, polimerini vermek için serbest radikal çözelti polimerizasyonuna girebilir. [1] Atom transfer radikal kopolimerizasyonu yoluyla bir dizi kopolimer oluturabilir. [6] Bir çalma, ürünün stiren, metakrilik asit ile emülsiyon terpolimerizasyonunu bildiriyor. [7] 2-etilheksil akrilat (EHA), akrilik polimerik lateksin bileenlerinden biridir. [2] Serbest radikal çözelti polimerizasyonuna urayabilir. [1] EHA’nn basnca duyarl yaptrclar oluturmak için metil metakrilat (MMA) ile serbest radikal emülsiyon ko-polimerizasyonuna urad bilinmektedir. [3] [4] Akrilonitril ve akrilamid ile kopolimerler de oluturabilir. [5] 2-Etilheksil akrilat (HA), akrilik asit ve 2-etil heksanolün esteridir. Yaptrc, kaplama, yap malzemeleri, akrilik kauçuk ve emülsiyonlarn yapmnda hammadde olarak kullanlr. 2-Etilheksil akrilat (HA), akrilik asit ve 2-etil heksanol esteridir. 2-etilheksil akrilatmz çok düük seviyedeki safszlklar ve çok çeitli kimyasallar için hammadde olarak kullanlabilir.2-Etilheksil akrilat (HA), yaptrclar, kaplamalar, yap malzemeleri, akrilik kauçuk ve emülsiyonlar yapmak için hammadde olarak kullanlr. 2-Etilheksil akrilat, 2-etil heksanol ve akrilik asitten sürekli bir ilemde katalitik dehidratizasyon ile üretilir. Sulu ilemin harcanan kül suyu bir atk su artma tesisinde ilenir. 2-Etilheksil akrilat, kimya endüstrisinde, esas olarak sulu polimer dispersiyonlarna ilenen polimerlerin ve kopolimerlerin üretimi için bir monomer olarak kullanlr. Polimerler ve polimer dispersiyonlar, yaptrclarda ve boyalar için balayc olarak kullanlr. Dier uygulamalar, kaplama ham maddelerini ve plastik ve tekstil endüstrilerindeki kullanmlar içerir. Ayrca 2-etilheksil akrilat, inaat sektörü kimyasallarnda (örn. Zemin kaplamalar, yol iaretleme maddeleri)% 0.1-21 arasndaki konsantrasyonlarda monomer olarak kullanlmaktadr. Çevreye 2-etilheksil akrilat salnmnn esas olarak atk su ve egzoz gazlar ile üretim ve ileme srasnda meydana gelmesi beklenmektedir. 2-etilheksil akrilatn fiziksel kimyasal özelliklerine göre, atmosfer datm için ana hedef bölmedir ve sadece küçük miktarlardr hidrosferde kalr. Hava bölmesindeki biyotik veya abiyotik etkilere ilikin veriler mevcut deildir. Atmosferdeki 2-etilheksil akrilatn ksa yar ömrü nedeniyle (yaklak 19 saat) yan etkiler beklenmez. Gda zinciri yoluyla daha yüksek organizmalarda birikmesi halinde maddenin toksik etkilere neden olup olmayacan deerlendirmek için memeli toksisite verilerine dayal snflandrma kullanlabilir. 2-Etilheksil akrilat, Çok Toksik veya Zehirli veya Zararl olarak snflandrlmamtr ve bir PNECoral tayini için kullanlabilecek diyet toksisite testlerinden yeterli veri yoktur. Bu nedenle ikincil zehirlenmenin kantitatif bir deerlendirmesi yaplamaz, ancak veri tabannn iyiletirilmesi 2-etilheksil akrilat için yüksek öncelikli deildir. 2-etilheksil akrilatn üretimi, ilenmesi ve kullanm için en kötü durumu temsil eden sahaya özel bir salm tahmini, atmosferik birikimi ve bu sahann yaknndaki toprak gözenek suyunda ortaya çkan konsantrasyonu hesaplamak için kullanld. 2-etilheksil akrilatn üretimi, ilenmesi ve kullanm için en kötü durumu temsil eden sahaya özel bir salm tahmini, atmosferik birikimi ve bu sahann yaknndaki toprak gözenek suyunda ortaya çkan konsantrasyonu hesaplamak için kullanld. 2-Etil Heksil Akrilat, katalizör görevi gören bir dehidratasyon ileminde 2-etil heksanol ve akrilik asidin reaksiyona sokulmasyla üretilir. 2-Etil Heksil Akrilat, alkaliler gibi oksitleyici maddelerle reaksiyona girecek ve stldnda polimerize olacaktr. Polimerizasyon hidrokinon tarafndan engellenir. 2-Etil Heksil Akrilat, kimyasal imalat endüstrisinde homopolimer ve ko-polimer emülsiyonu üretimi için kullanlr. Kaplamalar, boya kaplamalar, basnca duyarl yaptrclar (PSA) ve szdrmazlk malzemeleri, deri bitirme, boya katk maddeleri, tekstil ve kat kaplamalar için bir ko-polimer olarak kullanlr.2-Propenoik asit olarak da bilinen 2-etil heksil akrilat, 2-etilheksil ester; C11H20O2, CAS: 103-11-7 moleküler formülüne sahip bir akrilat monomeridir. Suda çözünmeyen, alkol ve eterlerde tamamen çözünebilen berrak bir svdr. 75-90 ° C arasnda bir parlama noktasna sahiptir ve karakteristik bir akrilik kokusuna sahiptir. 2-Etilheksil Akrilat (2-EHA), özel yüksek moleküler özelliklere göre uyarlamak için çok çeitli dier akrilik ve vinil monomerlerle kolayca kopolimerleen çok yönlü bir yap tadr Çok çeitli rijit olmayan uygulamalar için arlk kopolimer özellikleri. 2-EHA, daha yüksek bir alkil akrilat komonomer olarak, oda scaklnn çok altnda bir cam geçi scakl (homopolimer Tg – 65 ° C’dir), esneklik ve elastikiyet verir ve hidrofobik doa. Kopolimer bileimlerine katkda bulunan benzersiz özellikler arasnda düük scaklk esneklii, su direnci, iyi hava koullar özellikleri ve UV (güne ) direnci yer alr. Bu özelliklerden yararlanan birincil uygulamalar arasnda birden çok yaptrc, özellikle basnca duyarl yaptrclar (PSA), boya ve kaplamalar, dolgular ve szdrmazlk malzemeleri, tekstil ve kat cilalar ve bask mürekkepleri yer alr. 2-EHA netlie, toklua, a ve hava direnci ve kimyasal direnç, üreticiler 2-EHA içeren akrilik kopolimerleri iç, d, astar ve son kat boya ve kaplama formülasyonlarnda ve dier ilgili ürünlerde kullanabilirler. 2-EHA için yeni teknik uygulama alanlar homopolimer, poli ( 2-etilheksil akrilat), yüzey kaplamalar, film, tabaka ve basnca duyarl yaptrclar ve bantlar için plastikletirici malzeme olarak kullanlr. PSA’lara dahil edilen bir plastikletirici olarak, soyulma mukavemetinde, yapkanlkta bir arta neden olur ve ayn zamanda çkarlabilirlii gelitirebilir. 2-EHA, çocuk bezleri ve hijyen ürünleri için hzl ien ve oldukça gözenekli hidrojeller üretmek için süper emici kopolimerlerde kullanlr. 2-Etilheksil akrilat, çok çeitli kopolimer bileimleri içinde anahtar bir monomerdir. Serbest radikal polimerizasyon teknikleri, yüksek monomer dönüümleri ve çok yüksek makromolekül moleküler arlklar (> 200.000) salar. 2-EHA’nn kullanm kolayl ve ko-polimerizasyonu, emülsiyon, çözücü, süspansiyon ve yn polimerizasyonlarnda kullanma izin verir. BASF 2-Etilheksil Akrilat 2-Etilheksil akrilat% 98 2-Etilheksil akrilat, homopolimerleri ve kopolimerleri oluturur. 2-Etilheksil akrilat kopolimerleri akrilik asit ve tuzlar, amidleri ve esterleriyle ve metakrilatlar, akrilonitril, maleik asit esterleri, vinil asetat, vinil klorür, viniliden klorür, stiren, bütadien, doymam polyesterler ve kurutucu yalar vb. le hazrlanabilir. 2-Etilheksil akrilat ayn zamanda kimyasal sentezler için çok yararl bir hammaddedir, çünkü çok çeitli organik ve inorganik bileiklerle kolayca ilave reaksiyonlarna girer 2-Etilheksil akrilat, Propilen karbonat, Kuaterner amonyum bileikleri, Triglisidil izosiyanürat için Toksikolojik Deerlendirme ve Snr Deerleri ve Tripropilenglikol diakrilat Dorudan, akrilik asidin 2-etilheksanol ile asitle katalize edilmi esterletirilmesi, 2-etilheksil akrilat üretimi için balca yöntemdir.Bir polimerizasyon inhibitörü eklenir. (IARC 1994). 2-etilheksil akrilatn günümüzdeki balca kullanm, akrilik basnca duyarl yaptrclardr. Genel amaçl bir yapkan bant tipik olarak yaklak% 75 2-etilheksil akrilat içerir. 2-etilheksil akrilatn dier kullanmlar, plastik, lateks, boyalar, tekstil ve deri cilalar, kat kaplamalar ve endüstriyel metal kaplamalardr. (HSDB 1999, IARC 1994). Danimarka’da, 2-etilheksil akrilatn balca kullanm UV ile kürlenen mürekkepler, vernikler ve cilalardr. Emisyon, aerosoller eklinde gerçekleir. 2-Etilheksil akrilatn doal bir bileik olarak olutuu bilinmemektedir. Üretim ve kullanm srasnda kaçak ve baca emisyonlarnda veya atk sularda çevreye salnabilir. (HSDB 1999, IARC 1994). 2-Etilheksil akrilatn, buhar basncna bal olarak neredeyse tamamen buhar faznda bulunmas beklenmektedir. Güne nda fotolize olabilir. Fotokimyasal olarak üretilen hidroksil radikalleri ve ozon ile tahmini yarlanma ömrü 10,3 saat ile reaksiyona girecektir. (HSDB 1999). 2-Etilheksil akrilatn çökeltiye veya süspansiyon halindeki partikül maddeye adsorbe olmas beklenmemektedir. Yapsal olarak benzer etil akrilat için hidroliz verilerine dayal olarak, özellikle alkali sularda hidrolize olabilir. Güne nda fotolize olabilir. Butil akrilat ve etil akrilatn biyolojik olarak parçalanabilirliine bal olarak biyolojik olarak parçalanabilir. Tahmini yarlanma ömrü 7,3 saat ile 2,7 gün arasnda sudan önemli ölçüde uçacaktr. (HSDB 1999). 2-Etilheksil akrilatn toprakta orta derecede hareketlilik göstermesi ve bu nedenle yeralt suyuna szmas beklenmektedir. Yapsal olarak benzer etil akrilat için hidroliz verilerine dayanarak, özellikle alkali topraklarda hidrolize olabilir. Butil akrilatn biyolojik olarak parçalanabilirliine bal olarak biyolojik olarak parçalanabilir. Yüzeye yakn topraktan ve dier yüzeylerden buharlaabilir. (HSDB 1999). HSDB’ye (1999) göre 2-Etilheksil akrilatn suda yaayan organizmalarda biyolojik olarak konsantre olmas beklenmemektedir. Bununla birlikte BUA (1994), önemli miktarda biyoakümülasyonun beklenebileceini belirtmektedir. 2-etilheksil akrilata insan maruziyetinin en olas yolu, özellikle üretildii ve kullanld tesislerdeki kirli havann solunmasdr. Çalanlar ayrca dökülmeler veya szntlar srasnda dermal olarak maruz kalabilirler. (Samimi & Falbo 1982) Bir çalmada, erkek Wistar sçanlarna, vinil karbonlar üzerine etiketlenmi 10 mg / kg canl arlk (14C) -2-etilheksil akrilat intravenöz doz uygulanmtr (Gut ve dierleri 1988). Baka bir çalmada, erkek Wistar sçanlarna 10 mg / kg vücut arl veya 50 mg / kg vücut arl (14C) -2-etilheksil akrilat intravenöz doz uygulanmtr (Cikrt ve dierleri 1986). Dokulardaki en yüksek radyoaktivite konsantrasyonlar böbrek, karacier, beyin, timüs ve dalakta bulunmutur. 2-Etilheksil akrilatn, dier akrilat esterler gibi 2-etilheksanol ve akrilik aside karboksilesteraz katalizli hidrolize uradna inanlmaktadr (Cikrt ve ark.1986 , Miller ve dierleri 1981 – IARC 1994’ten alntlanmtr). 2-Etilheksil akrilat, örnein glutatyondaki protein olmayan SH gruplaryla küçük ölçüde reaksiyona girerek protein olmayan SH gruplarnn tükenmesine ve tiyoeterlerin idrarla atlmasna neden olur. aadaki çalmalar: 24 saat boyunca 250 ila 4800 mg / m3 konsantrasyonlarda 2-etilheksil akrilata 6 saat inhalasyon yoluyla maruz kalan erkek Wistar sçanlar, doza bal bir ekilde idrarda tiyoeterleri salglayarak% 8,0’dan% 3,0’a (1000 mg / m3’te) ) Bu yol boyunca doyurulabilir metabolizmay gösteren 2-etilheksil akrilat dozu. 2400 mg / m3 ve üzerindeki konsantrasyonlarda kan, karacier ve beyindeki protein d SH gruplarnn doza bal olarak azald görülmütür. (Vodicka ve ark. 1990) Erkek Wistar sçanlarna intraperitoneal dozda 10 mg / kg canl arlk (14C) -2-etilheksil akrilat uygulandnda, vinil karbonlar üzerinde etiketlenmi dozun% 2’si idrarda tiyoeter olarak bulundu ( Gut ve dierleri 1988) .Erkek Wistar sçanlarnda intraperitoneal veya intravenöz (14C) -2-etilheksil akrilat dozu verilen iki çalmada solunan havada elimine edilen balca metabolit karbondioksitti (Gut ve dierleri 1988, Sapota 1988).2-etilheksil akrilat ve metabolit akrilik asidi, indirgenmi glutatyon (GSH) formu ile reaksiyona girdiinde, merkaptürik asitler oluabilir (Cikrt ve dierleri 1986). 2-Etilheksil akrilatn, 2-etilheksanole karboksilesteraz katalizli hidrolize uradna inanlmaktadr. ve akrilik asit, dier akrilat esterler gibi (Cikrt ve dierleri 1986, Miller ve dierleri 1981 – IARC 1994’ten alnt). 2-Etilheksil akrilat, örnein glutatyonda protein olmayan SH gruplaryla küçük bir reaksiyona girerek, protein olmayan SH gruplar ve tiyoeterlerin idrarda atlmas aadaki çalmalarda açkland gibi: 250 ila 4800 mg / m3 konsantrasyonlarda 2-etilheksil akrilata 6 saat soluma ile maruz braklan erkek Wistar sçanlar, tiyoeterleri bir dozda idrarla att 2-etilheksil akrilat dozunun% 8.0’den% 3.0’na (1000 mg / m3’te) azalmas, bu yol boyunca doyabilir metabolizmay gösterir. 2400 mg / m3 ve üzerindeki konsantrasyonlarda kan, karacier ve beyindeki protein d SH gruplarnn doza bal olarak azald görülmütür. (Vodicka ve ark. 1990). Erkek Wistar sçanlarna intraperitoneal dozda 10 mg / kg canl arlk (14C) -2-etilheksil akrilat uygulandnda, vinil karbonlar üzerinde etiketlenmi dozun% 2’si idrarda tiyoeter olarak bulundu ( Gut ve dierleri 1988) .Eer solunmu havada elimine edilen balca metabolit, intraperitoneal veya intravenöz (14C) -2-etilheksil akrilat dozu verilen erkek Wistar sçanlarnda yaplan iki çalmada karbondioksitti (Gut ve dierleri 1988, Sapota 1988). 2-etilheksil akrilat ve metabolit akrilik asidi, indirgenmi glutatyon formuyla (GSH) reaksiyona girdiinde, merkaptürik asitler oluabilir (Cikrt ve ark. 1986). Erkek Wistar sçanlarna intravenöz 10 mg / kg vücut arl veya 50 doz uygulanmtr. mg / kg bw (14C) -2-etilheksil akrilat. Uygulamadan sonraki ilk 24 saat içinde 1-3 saatlik aralklarla radyoaktivitenin safra atlm takip edildi. Safra aknda önemli bir art (% 243) gözlendi. 24 saatte, dozun% 2.2’si her iki dozda safra yoluyla, çou (% 83) ilk 3 saatte atld. (Cikrt ve ark. 1986) Yedi kiide akrilik bazl yapkan bant nedeniyle alerjik kontakt dermatit gelimitir. Yama testi, tüm kiilerin 2-etilheksil akrilata tepki gösterdiini ortaya çkard. Be kii, çapraz duyarllama modelleri için ayrca test edildi. Hepsi 2-etilbutilakrilata reaksiyona girdi ve bazlar dier akrilatlara da reaksiyon gösterdi. (Ürdün 1975). Finlandiya’da 1990’dan 1994’e kadar 2-etilheksil akrilatn neden olduu 5 mesleki temas ürtikeri vakas bildirilmitir (Kanerva ve dierleri 1996 – 1981-1999 öncesi Toxline’dan alnt) Sçanlar doymu bir atmosfere maruz kaldnda (yaklak 1400 mg / m3) 2-etilheksil akrilat 8 saat boyunca hiçbir ölüm meydana gelmedi (BASF 1958 – IUCLID 1996’dan alnt) Alderley Park fareleri (grup bana her cinsiyetten 2 hayvan) etanol içinde 2-etilheksil akrilata maruz brakld. 375 ve 1000 mg / m3 2½haftada günde 6 saat, haftada 5 gün. Yüksek dozlu hayvanlarda vücut arl art, uyuukluk ve dispne azald. Kanda, idrarda ve patolojide deiiklik gözlenmedi.Düük doz hayvanlar hiçbir toksik iaret göstermedi. (Gage 1970 – IUCLID 1996’dan alntlanmtr). 2-etilheksil akrilat için bildirilen oral LD50 deerleri, fareler için 4,4 ila 12,8 g / kg (bildirilen 5 deer) ve fareler için 4,4 ila 5,0 g / kg aralndadr ( 2 deer bildirildi). Tavanlar, 3.5 g / kg’dan daha büyük bir oral LD50-deerine sahiptir ve kediler için deer 1.8 g / kg’dan büyüktür (her tür için 1 deer rapor edilir). (IUCLID 1996’da alntlanan çalmalar, Clayton & Clayton 1994, DPIMR 1981, BUA 1994). Tavanlar (cinsiyet bana 1 hayvan), 6 için 1774 mg / kg’lk bir dozda bir tüpten% 10 emülsiyon olarak 2-etilheksil akrilat ile beslendi. gün (erkek) veya 8 gün (kadn). Dört dii tavan, 10 gün boyunca 887 mg / kg’lk bir dozla beslendi. Yüksek doz hayvanlar 6 veya 8 gün sonra öldü. Düük vücut arl art, yemek yeme istei eksiklii ve zayf kas tonusu gözlendi ve mide mukozas ve böbrekler hasar gördü. Düük dozlu hayvanlar sadece anlk yemek yeme arzusu eksiklii ve vücut arl artnda biraz azalma gösterdi. (BASF 1960 – BUA 1994’ten alnt). Dii Dunkin Hartley soyundan çkm gine domuzlar, 9 gün boyunca Freund’un tam adjuvannda 0.5 M veya 0.17 M konsantrasyonlarda intradermal 2-etilheksil akrilat enjeksiyonlar ile indüklendi. Hayvanlar 21, 35 ve 49. günlerde epikütan olarak uygulanan 1 M 2-etilheksil akrilat ile tehdit edildiinde duyarllama gözlemlendi. 0.5 M’lik bir indüksiyon konsantrasyonunda 16 hayvandan 6-11’i duyarl hale getirildi. 0.17 M 11-13 indüksiyon konsantrasyonunda 16 hayvandan 11-13 duyarl hale getirildi. Dört kontrol hayvan duyarl hale getirildi (3’ü 35. günde ve 1’i 49. günde). Etil akrilat, n-butil akrilat ve heksil akrilat ile çapraz reaksiyon görüldü. (Waegemaekers & van der Walle 1983) Gine domuzlar, 3 hafta boyunca haftada 3 kez epikutanöz veya intrakutanöz uygulanan% 0.1 (w / v) 2-etilheksil akrilat ile indüklendi. Duyarllama, indüksiyon için kullanlanla ayn 2-etilheksil akrilat konsantrasyonuyla indüksiyondan sonra 11. günde hayvanlara meydan okunduunda gözlemlendi. Epikutanöz test için, 10 hayvandan 10’u duyarl hale getirildi. ntrakütan test için, 10 hayvandan 7’si duyarl hale getirildi. (Hunter ve dierleri 1966 – Nordisk Ministerråd 1991’den alntlanmtr) Polak yönteminde, her iki cinsiyetten 6 Hartley soy d kobay, ayak tabanlarna enjeksiyon olarak uygulanan Freund’un tam adjuvan içinde 1 mg 2-etilheksil akrilat ile indüklendi. boyun. % 1 veya% 5 2-etilheksil akrilat ile indüksiyondan sonra 7. günde hayvanlara meydan okunduunda duyarllama gözlemlendi. (Parker & Turk 1983) Yaamlar boyunca haftada üç kez 20 mg% 75 (v / v) 2-etilheksil akrilat ile tedavi edilen C3H / HeJ farelerinde (% 68) kronik nefrit sklnda belirgin bir art vard. Negatif kontrole kyasla (% 15) krplm srt derisine aseton uygulanmtr. Sakalm, 2-etilheksil akrilat ile muameleden etkilenmedi. (DePass ve dierleri 1985). 3 ay boyunca haftada 3 kez aseton içinde 25 ml% 21 veya% 86.5 2-etilheksil akrilat dozlarna maruz braklan Erkek NMRI ve C3H / HeJ fareleri (grup bana 10 hayvan) cilt tahrii gösterdi. NMRI fareleri, C3H / HeJ farelerinden daha az duyarlyd. % 21 2-etilheksil akrilat verilen NMRI farelerinde cilt tahrii gözlenmedi. (BASF 1985 – IUCLID 1996’dan alnt). 2-etilheksil akrilat ile NMRI veya C3H / HeJ farelerine (grup bana 80 hayvan) haftada 3 kez uygulanan uzun vadeli (2 yl veya ömür boyu) karsinojenisite çalmalarnda, cilt tahrii (ölçekleme , kabuklanma, hiperkeratoz, hiperplazi, kabuk oluumu ve ülserasyon) gözlendi. Sakalm, 2-etilheksil akrilat ile muameleden etkilenmedi ve hiçbir sistemik etki görülmedi. (Mellert ve dierleri 1994, Wenzel-Hartung ve dierleri 1989). C3H / HeJ farelerine uygulanan en düük doz, aseton içinde 25 ml% 2.5 (arlk / arlk) 2-etilheksil akrilat solüsyonudur. Bu dozda cilt tahrii gözlendi, ancak tedavinin 11. haftasndan sonra bu lezyonlar geri dönüümlü oldu. Bir grup C3H / HeJ faresi, 24 hafta boyunca% 43’lük bir çözelti ile tedavi edildi ve daha sonra ömür boyu gözlendi. Tedavi durdurulduktan hemen sonra% 43 grubunda cilt lezyonlar geri dönüümlüdür.Daha yüksek dozlar için (% 21 ve% 86,5) baka deri lezyonlar geliti. (Wenzel-Hartung ve dierleri 1989). 3 veya 12 gün süreyle günde 1 ml 2-etilheksil akrilata maruz braklan erkek ve dii Yeni Zelanda beyaz tavanlar (her cinsiyetten 2 veya 1 hayvan) deri iltihab gelitirdi. 12 gün sonra nekrozlar ve ülserler de gözlendi. (Hunter ve dierleri 1981 – IUCLID 1996’dan alntlanmtr). 12 gün boyunca günde 0.5 ml 2-etilheksil akrilata maruz braklan erkek ve dii kobaylarda (her cinsiyetten 5 hayvan) deri iltihab, nekrozlar ve ülserler gelimitir. Lezyonlar, çift doz 2-etilheksil akrilata maruz kalan tavanlarda görülen lezyonlardan daha kötüydü. (Hunter ve dierleri 1981 – IUCLID 1996’dan alntlanmtr). 2-Etilheksil akrilat, metabolik aktivasyon sistemleri olan veya olmayan bir Ames testinde Salmonella typhimurium’un 4 suunda (TA98, TA100, TA1535 ve TA1537) mutajenik deildi (Zeiger ve dierleri 1985) .2-Etilheksil akrilat, eksojen aktivasyon olmakszn kültürlenmi L5178Y fare lenfoma hücrelerinde test edildi, artm mutant frekans ve indüklenen anormallikler için üpheli bir sonuç üretti. Mikronüklei saysnda art görülmedi. (Dearfield ve dierleri 1989) Baka bir deneyde, mutasyon frekans, metabolik aktivasyonlu kültürlenmi L5178Y fare lenfoma hücrelerine eklenen en yüksek 2-etilheksil akrilat doz seviyeleri için kontrollere göre 4.6 kat daha fazlayd. Metabolik aktivasyon olmadan mutasyon sklnda tekrarlanabilir bir art görülmedi. (Litton Bionetics 1984 – HSDB 1999’dan alntlanmtr). 2-Etilheksil akrilat, Çin hamsteri yumurtalk hücrelerinde ne süspansiyonda ne de tek tabakal deneyde hgprt mutant sklnda doza bal bir arta neden olmamtr (Moore ve dierleri, 1991). C3H-10T1 / 2 hücrelerindeki transformasyon testi, 2-etilheksil akrilat ile negatif olarak test edildi (BASF 1982 – IUCLID 1996’dan alnt). Metabolik aktivasyon içeren ve içermeyen CHO hücrelerinde karde kromatid deiim testi, 2-etilheksil akrilat ile metabolik aktivasyon (belirsiz sonuç) (BASF 1980 – IUCLID 1996’dan alnt). 2-etilheksil akrilat ile test edildiinde birincil sçan hepatositlerinde zamanlanmam DNA sentezi biraz artt (belirsiz sonuç) (BASF 1980 – IUCLID 1996’dan alnt). Kromozom sapmalar yok farelere bir in vivo sitogenetik testte (BASF – alnt IUCLID 1996) günde bir kez 2.5 g / kg oral doz verildiinde gözlemlenmitir (IUCLID 1996’da alntlanmtr). 2 yllk bir karsinojenisite çalmasnda 25 ml 21.5, 43 veya 85 Aseton içindeki% (arlk / arlk) 2-etilheksil akrilat solüsyonu, haftada üç kez erkek NMRI farelerinin (grup bana 80) krplm srt derisine epikutan olarak uyguland. Yaklak 7 ay sonra her grubun yars tedavi için 2 ay dinlendirildi ve daha sonra 20 hafta süreyle bir destekleyici ile tedavi edildi. Tek bana 2-etilheksil akrilat ile tedavi edilen farelerin hiçbiri uygulama bölgesinde bir deri tümörü gelitirmedi. 2-etilheksil akrilat ve destekleyici ile muamele edilen gruplarn her birinde bir skuamöz hücre papillomu olutu. Skuamöz hücre karsinomlar, sadece pozitif kontrol gruplarnda gözlendi (tek bana veya promoter ile kombinasyon halinde% 0.015 benzo [a] pirene maruz brakld).(Mellert ve ark. 1994) Bir ömür boyu kanserojenlik çalmasnda, aseton içinde 25 ml% 2.5, 21 veya 86.5 (arlk / arlk) 2-etilheksil akrilat çözeltisi, erkek C3H / HeJ farelerinin krplm srt derisine epikütan olarak uyguland. (Grup bana 80) haftada üç kez. Baka bir grup 24 hafta boyunca% 43’lük bir çözelti ile tedavi edildi ve daha sonra ömür boyu gözlendi. Sadece kronik tahri edici cilt hasar gösteren% 86.5 ve% 21 test gruplarnda, doz bamll olmakszn yüksek neoplastik cilt lezyonlar (toplam 15 papillom, 36 karsinom ve 16 melanom) görülmütür. Aksine, negatif kontrol gruplarnda, ömür boyu% 2.5 2-etilheksil akrilat ile tedavi edilen grupta veya yaklak 6 ay boyunca% 43 2-etilheksil akrilat ile tedavi edilen grupta cilt tümörü bulunmad ve sonra ömür boyu gözlendi. (Wenzel-Hartung ve ark. 1989). Bir ömür boyu kanserojenlik çalmasnda, aseton içinde 20 mg% 75 (v / v) 2-etilheksil akrilat çözeltisi, 40 erkek C3H / HeJ faresinin üçünün krplm srt derisine epikütan olarak uygulanmtr. haftada bir kez. Konsantrasyon, 2 haftalk bir ön çalmada ne büyük ölçüde gözlemlenebilir tahrie ne de kilo almnda azalmaya neden olan en yüksek konsantrasyon olarak seçildi. ki hayvann skuamöz hücreli karsinomlar vard ve dört ilave hayvann tümü tedavi edilen deri üzerinde skuamöz hücreli papillomlara sahipti. (DePass ve dierleri, 1985). 2-Etilheksil akrilat, keskin, küf kokulu renksiz bir svdr. Sudaki çözünürlüü düüktür (0.1 g / l). Buhar basnc 0.14 mmHg’dir. Havadaki koku eii 0,55-1,36 mg / m3’tür. Danimarka’da 2-etilheksil akrilatn balca kullanm UV ile kürlenen mürekkepler, laklar ve verniklerdir. 2-Etilheksil akrilatn doal bir bileik olarak olutuu bilinmemektedir. Üretim ve kullanm srasnda kaçak ve yn emisyonlarnda veya atk suda çevreye salnabilir. 2-etilheksil akrilat, atmosfere salnrsa, fotokimyasal olarak üretilen hidroksil radikalleri ve tahmini yar ömrü 10,3 saat olan ozonla reaksiyona girecektir. Güne nda da fotolize olabilir. 2-etilheksil akrilat, topraa ve suya salnrsa biyolojik olarak parçalanabilir ve özellikle alkali bir ortamda hidrolize olabilir. 2-Etilheksil akrilatn suda çökeltiye veya süspanse partikül maddeye adsorbe olmas beklenmez. Toprakta orta derecede hareketlilik göstermesi beklenmektedir. 2-Etilheksil akrilat, tahmini yarlanma ömrü 7,3 saat ile 2,7 gün arasnda sudan ve yüzeye yakn topraktan önemli ölçüde uçacaktr. Sçanlarda 2-etilheksil akrilat, gastrointestinal kanaldan ve intraperitoneal uygulamadan sonra kolaylkla emilir. Plazma radyoaktivite konsantrasyonu 2-3 saatte zirve yapt. Absorpsiyonu takiben 2-etilheksil akrilat çeitli organlara datlr ve en yüksek konsantrasyon karacier ve böbrekte oluur. 2-Etilheksil akrilat hzla metabolize olur ve vücuttan atlr. Yüksek dozlarda (100 mg / kg canl arlk) dokulardaki konsantrasyondaki düü, ya dokusunda 72 saat boyunca neredeyse sabit kalan seviyelerle daha yavat.2-Etilheksil akrilatn, dier akrilat esterler gibi alkole ve akrilik aside karboksilesteraz katalizli hidrolize maruz kaldna inanlmaktadr. 2-Etilheksil akrilat küçük bir dereceye kadar protein olmayan SH gruplaryla reaksiyona girerek tiyoeterlerin ve merkaptürik asitlerin idrar ve / veya safra ile atlmasna neden olur. Ana atlm yolu akcierler (% 50-75) ve ardndan idrar (% 7-41) ve dk (% 0.01-3). Akcierlerdeki metabolit CO2’dir. Akrilik bazl yapkan bant nedeniyle yedi alerjik kontakt dermatit vakas bildirilmitir. Yama testi, tüm kiilerin 2-etilheksil akrilata tepki gösterdiini ortaya çkard. Solunum duyarll vakas bildirilmemitir. Finlandiya’da 5 kii, 2-etilheksil akrilat nedeniyle temas ürtikeri geçirdi. 2-etilheksil akrilatn tekli peroral, dermal veya solunum yoluyla uygulanmasnn her birinin yalnzca hafif toksik olduu kantland (fareler için LC50 deeri 7700 mg / m3’ten büyük; oral LD50 -deerler farkl türler için 1.8 ila 12.8 g / kg arasnda deiiyordu ve dermal LD50 deerleri farkl türler için 7.5 ila 16 g / kg arasnda deiiyordu). Sçanlar 8 saat boyunca yaklak 1400 mg / m3 2-etilheksil akrilat teneffüs ettiklerinde hayr Alderley Park sçanlarnda günde 6 saat, haftada 5 gün 2½ hafta süreyle 1000 mg / m3 2-etilheksil akrilat soluyan Alderley Park sçanlarnda vücut arl art, uyuukluk ve dispne azald. Ayn maruziyet süresi boyunca 375 mg / m3 teneffüs eden hayvanlar hiçbir toksik iaret göstermedi. Freund’un tam adjuvannda 0.5 M veya 0.17 M konsantrasyonlarda intradermal 2-etilheksil akrilat enjeksiyonlar ile indüklenen zorlanm kobaylarda cilt hassaslamas gözlendi. 9 gün boyunca üç kez; 3 hafta boyunca haftada 3 kez% 0.1 (w / v) konsantrasyonlarda epikutanöz veya intrakutanöz 2-etilheksil akrilat uygulamasyla indüklenen; veya Polak yönteminde Freund’un ayak tabanlarna ve boynuna enjeksiyon olarak uygulanan komple adjuvan içinde 1 mg 2-etilheksil akrilat ile indüklendiini, Fare, tavan ve kobaylarn derisine tekrar tekrar uygulanmas ciltte tahrie ve ardndan dejenerasyona neden oldu. tedavi edilen alanlarn. C3H fareleri, NMRI farelerinden daha duyarlyd. Farelere haftada 3 kez uygulanan 2-etilheksil akrilat ile ömür boyu yaplan bir çalmada cilt tahrii görülmütür. Uygulanan en düük doz, aseton içinde 25 ml% 2.5 (arlk / arlk) 2-etilheksil akrilat solüsyonudur. Bu dozda cilt tahrii gözlendi, ancak tedavinin 11. haftasndan sonra bu lezyonlar geri dönüümlü oldu. Daha yüksek dozlar için (% 21 ve% 86,5) baka deri lezyonlar geliti. Bir çalmada 2-etilheksil akrilat tavan gözü için tahri edici deildi, ancak bir dierinde tahri edici deildi. Wistar’n burun mukozasnn koku alma epitelyumu dejenere olmutu. sçanlar 2-etilheksil akrilat 225 ve 750 mg / m3’te günde 6 saat, haftada 5 gün 90 gün süreyle soludu. Bu dozlarda vücut arl artnda azalma, uyuukluk ve albümin seviyelerinde azalma da gözlendi. Ayn maruziyet süresi boyunca 75 mg / m3 teneffüs eden hayvanlar hiçbir toksik iaret göstermedi. 20 mg% 75 (v / v) ile ömürleri boyunca haftada üç kez tedavi edilen erkek C3H / HeJ farelerde kronik nefrit sklnda belirgin bir art görüldü. ) Krplm srt derisine uygulanan aseton içinde 2-etilheksil akrilat.