ALLANTOINE (ALLANTON)
ALLANTOINE (ALLANTOIN)
CAS NUMBER; 97-59-6
EC NUMBER; 202-592-8
SYNOYMS; Glyoxyldiureide, 5-Ureidohydantoin; Allantoin; allantoin; 97-59-6; 5-Ureidohydantoin; Glyoxyldiureide; 1-(2,5-dioxoimidazolidin-4-yl)urea; Glyoxyldiureid; Allantol; Cordianine; Sebical; Alantan; AVC/Dienestrolcream; Urea, (2,5-dioxo-4-imidazolidinyl)-; Hydantoin, 5-ureido-; Cutemol emollient; Uniderm A; Glyoxylic diureide; (2,5-Dioxo-4-imidazolidinyl)urea; Psoralon; Septalan; Caswell No. 024; (2,5-dioxoimidazolidin-4-yl)urea; Glyoxylic(acid) diureide; 5-Ureido-2,4-imidazolidindion; NSC 7606; Ureidohydantoin; CCRIS 1958; Allantoin [USAN:BAN]; Fancol TOIN; 5-Ureidohydrantoin; N-(2,5-Dioxo-4-imidazolidinyl)urea; EPA Pesticide Chemical Code 085701; AI3-15281; NSC7606; 2,5-Dioxo-4-imidazolidinyl-urea; Allantoin (JAN/USP); EINECS 202-592-8; BRN 0102364; urea, N-(2,5-dioxo-4-imidazolidinyl)- MLS000737882; C4H6N4O3; CHEBI:15676; 4-ureido-2,5-Imidazolidinedione; POJWUDADGALRAB-UHFFFAOYSA-N; MFCD00005260; N-(2,5-dioxoimidazolidin-4-yl)urea; DSSTox_CID_43Herpecin L; D00121; DSSTox_RID_75334; DSSTox_GSID_20043; (S)-Allantoin; N-[2,5-dioxoimidazolidin-4-yl]urea; SMR000528073; amino-N-(2,5-dioxo(1,3-diazolidin-4-yl))amideSR-01000766252; allantion; Allantoinum; Allantoi; Hemocane; DL-Allantoin; HSDB 7490; Allantoin [USAN:USP:BAN:JAN]; CAS-97-59-6; Prestwick_11; NCGC00016358-01; 5-ureido-Hydantoin; Allantoin (8CI); 5-eaAoAOEO; (+/-)-Allantoin; Spectrum_001078; ACMC-209twn; Prestwick0_000002; Prestwick1_000002; Prestwick2_000002; Prestwick3_000002; Spectrum2_000219; Spectrum3_000876; Spectrum4_000716; Spectrum5_001526; bmse000437; D01HNL; AC1L18PM; AC1Q2AJ8; SCHEMBL3208; Oprea1_621175; Allantoin, 98% 250g; BSPBio_000003; BSPBio_002551; KBioGR_001271; KBioSS_001558; 5-25-15-00338 (Beilstein Handbook Reference); KSC679I2B; MLS002473300; Allantoin, analytical standard; Bio-0219; DivK1c_000281; SPECTRUM1500801; SPBio_000237; SPBio_001924; BPBio1_000005; CHEMBL593429; 5-Ureido-2,4-imidazolidindione; DTXSID3020043CTK5H9420; HMS500O03; KBio1_000281; KBio2_001558; KBio2_004126; KBio2_006694; KBio3_002051; Allantoin, >=98.0% (N); MolPort-001-779-876; NINDS_000281; Urea,5-dioxo-4-imidazolidinyl)-; HMS1568A05; HMS1921I10; HMS2092K16; HMS2095A05; HMS2268N08; Pharmakon1600-01500801; component of Skin-balm (Salt/Mix); HY-N0543; NSC-7606; 2,5-Imidazolidinedione, 4-ureido-; Tox21_110395; Tox21_202087; Tox21_302912; ANW-43029; BBL027508; CCG-39781; NSC757792; SBB003997; STL373778; AKOS000120642; AKOS016038547Tox21_110395_1; CS-7741; LS-7181; MCULE-1008326286; NSC-757792; RL06095; RTR-038622; SDCCGMLS-0066595.P001; 1-(2,5-Dioxoimidazolidin-4-yl);urea;IDI1_000281; KS-0000005S; Allantoin, p.a., 98.5-101.0%; N-(2,5-Dioxo-4-imidazolidinyl)urea #; NCGC00094854-01; NCGC00094854-02; NCGC00094854-03; NCGC00094854-04; NCGC00094854-05; NCGC00094854-07; NCGC00256403-01; NCGC00259636-01; (RS)-(2,5-dioxoimidazolidin-4-yl)urea; 4CN-0784; 5377-33-3; AC-11040; AK-77679; AN-24454; AS-13865; H736; NCI60_041675; SC-18051; N-(2,5-Dioxo-4(1h)-imidazolidinyl)urea; SBI-0051759.P002; KB-212681; ST2408512; TR-038622; A0211; AB00052307; BG01500390; FT-0604592; ST50308144; C01551; J10470; M-5668; Urea, (2,5-dioxo-4-imidazolidinyl)- (9CI); AB00052307_11; I05-0376; J-522839; SR-01000766252-2; SR-01000766252-3; SR-01000766252-4W-100104; I14-13401; Allantoin, European Pharmacopoeia (EP) Reference Standard; A999F0D6-0285-41D9-A6BA-B705987B663C; Allantoin, United States Pharmacopeia (USP) Reference Standard; Allantoin, Pharmaceutical Secondary Standard; Certified Reference Material; Ao>>u(1/4)a paragraph signthorn-micro feminineA Ie-2,4- paragraph signthornI feminine; 37305-69-4; 5-Ureidohydantoin; Glyoxyldiureide; Glyoxylic diureide; Cordianine; Glyoxyldiureid; (2,5-Dioxo-4-imidazolidinyl)urea; 58308-55-7; Allantoin; Herpecin L; Herpecin-L; HerpecinL; Sebical; Woun’dres; 5-Ureidohydantoin, Glyoxylic(acid) diureide; (2,5-DIOXO-4-IMIDAZOLIDINYL) – UREA; (2,5-DIOXO-4-IMIDAZOLIDINYL) UREA; 5-UREIDOHYDANTOIN; GLYOXYLDIUREID; GLYOXYLDIUREIDE; GLYOXYLIC DIUREIDE; UREA, (2,5-DIOXO-4-IMIDAZOLIDINYL) -; UREA, (2,5DIOXO4IMIDAZOLIDINYL) ; (2,5-DIOXO-4-IMIDAZOLIDINYL) UREA; 5-UREIDOHYDANTOIN; AI3-15281; (±)-Allantoin; (±)-Allantoin; 1-(2,5-Dioxo-4-imidazolidinyl)harnstoff [German] [ACD/IUPAC Name]; 1-(2,5-Dioxo-4-imidazolidinyl)urea [ACD/IUPAC Name]; 1-(2,5-Dioxo-4-imidazolidinyl)urée [French] [ACD/IUPAC Name]; 1-(2,5-Dioxoimidazolidin-4-yl)harnstoff; 1-(2,5-dioxoimidazolidin-4-yl)urea; 2,5-Dioxo-4-imidazolidinyl-urea; 202-592-8 [EINECS]; 344S277G0Z; 39669-95-9 [RN]; 4H-imidazole-2,5-diol, 4-[(hydroxyiminomethyl)amino]-
4-ureido-2,5-Imidazolidinedione; 5-Ureido-2,4-imidazolidindion; 5-ureido-Hydantoin; 97-59-6 [RN]; Allantoin [BAN] [JAN] [USAN] [USP] [Wiki]; Allantoin (8CI); DL-Allantoin; N-(2,5-Dioxo-4-imidazolidinyl)urea; UNII:344S277G0Z; Urea, (2,5-dioxo-4-imidazolidinyl)-; Urea, (2,5-dioxo-4-imidazolidinyl)- (9CI); Urea, N-(2,5-dioxo-4-imidazolidinyl)- [ACD/Index Name]; 5-Ureidohydrantoin; Fancol TOIN; (2,5-diketoimidazolidin-4-yl)urea; (2,5-dioxo-4-imidazolidinyl)-urea; (2,5-Dioxo-4-imidazolidinyl)urea; (2,5-dioxoimidazolidin-4-yl)urea; (2,5-Dioxo-imidazolidin-4-yl)-urea; (RS)-(2,5-dioxoimidazolidin-4-yl)urea; [97-59-6]; 2,5-dioxoimidazolidin-4-ylurea; 2,5-Imidazolidinedione, 4-ureido-; 5-Ureido-2,4-imidazolidindione; 5-Ureido-2,4-imidazolidinedione; Actinac; Alantan; Allantoi; allantoin 98%; Allantoin CTFA allantoin standard; allantoin, ???; allantoin, 98%; allantoin, powder; Allantoinum; Allantol; Alloxantin [Wiki]; Alphosyl; amino-N-(2,5-dioxo(1,3-diazolidin-4-yl))amide; AVC/Dienestrolcream; c4h6n4o3; Cordianin; Cutemol emollient; Dermalex; DL-ALLANTOIN-5-13C,1-15N; Glyoxyldiureid; Glyoxylic diureide; Glyoxylic(acid) diureide; Hemocane; Hydantoin, 5-ureido-; MFCD00005260 [MDL number]; N-(2,5-dioxoimidazolidin-4-yl)urea; Paxyl [Wiki]; Pharmakon1600-01500801; ProClin 300; Psoralon
S-allantoin; Sebical; Septalan; Uniderm A; Urea, (2, 5-dioxo-4-imidazolidinyl)-; Ureidohydantoin.; YT1600000; ??? [Chinese]; (2,5-Dioxo-4-imidazolidinyl)urea
2,5-Dioxo-4-imidazolidinyl-urea; 4-ureido-2,5-imidazolidinedione; 5-Ureido-2,4-imidazolidindione; 5-Ureidohydantoin; 5-ureidohydantoin; glyoxyldiureide; N-(2,5-Dioxo-4-imidazolidinyl)urea; InChI=1S/C4H6N4O3/c5-3(10)6-1-2(9)8-4(11)7-1/h1H,(H3,5,6,10)(H2,7,8,9,11); POJWUDADGALRAB-UHFFFAOYSA-N; Urea, (2,5-dioxo-4-imidazolidinyl)-; 1-(2,5-dioxoimidazolidin-4-yl)urea; Urea, (2,5-dioxo-4-imidazolidinyl)-; Allantol; AVC/Dienestrolcream; Cordianine; Glyoxyldiureid; Glyoxyldiureide; Hydantoin, 5-ureido-; Sebical; 5-Ureidohydantoin; 2,5-Dioxo-4-imidazolidinyl-urea; Alantan; Glyoxylic diureide; 5-Ureidohydrantoin; Fancol TOIN; Psoralon; Septalan; 2,5-Imidazolidinedione, 4-ureido-; NSC 7606; Urea, N-(2,5-dioxo-4-imidazolidinyl)-; Glyoxyldiureide, 5-Ureidohydantoin; Allantoin; allantoin; 97-59-6; 5-Ureidohydantoin; Glyoxyldiureide; 1-(2,5-dioxoimidazolidin-4-yl)urea; Glyoxyldiureid; Allantol; Cordianine; Sebical; Alantan; AVC/Dienestrolcream; Urea, (2,5-dioxo-4-imidazolidinyl)-; Hydantoin, 5-ureido-; Cutemol emollient; Uniderm A; Glyoxylic diureide; (2,5-Dioxo-4-imidazolidinyl)urea; Psoralon; Septalan; Caswell No. 024; (2,5-dioxoimidazolidin-4-yl)urea; Glyoxylic(acid) diureide; 5-Ureido-2,4-imidazolidindion; NSC 7606; Ureidohydantoin; CCRIS 1958; Allantoin [USAN:BAN]; Fancol TOIN; 5-Ureidohydrantoin; N-(2,5-Dioxo-4-imidazolidinyl)urea; EPA Pesticide Chemical Code 085701; AI3-15281; NSC7606; 2,5-Dioxo-4-imidazolidinyl-urea; Allantoin (JAN/USP); EINECS 202-592-8; BRN 0102364; urea, N-(2,5-dioxo-4-imidazolidinyl)-; MLS000737882; C4H6N4O3; CHEBI:15676; 4-ureido-2,5-Imidazolidinedione; POJWUDADGALRAB-UHFFFAOYSA-N; MFCD00005260; N-(2,5-dioxoimidazolidin-4-yl)urea; DSSTox_CID_43; Herpecin L; D00121; DSSTox_RID_75334; DSSTox_GSID_20043; (S)-Allantoin; N-[2,5-dioxoimidazolidin-4-yl]urea; SMR000528073; amino-N-(2,5-dioxo(1,3-diazolidin-4-yl))amide; SR-01000766252; allantion; Allantoinum; Allantoi; Hemocane; DL-Allantoin; HSDB 7490; Allantoin [USAN:USP:BAN:JAN]; CAS-97-59-6; Prestwick_11; NCGC00016358-01; 5-ureido-Hydantoin; Allantoin (8CI); 5-eaAoAOEO; (+/-)-Allantoin; Spectrum_001078; ACMC-209twn; Prestwick0_000002; Prestwick1_000002; Prestwick2_000002; Prestwick3_000002; Spectrum2_000219; Spectrum3_000876; Spectrum4_000716; Spectrum5_001526; bmse000437; D01HNL; AC1L18PM; AC1Q2AJ8; SCHEMBL3208; Oprea1_621175; Allantoin, 98% 250g; BSPBio_000003; BSPBio_002551; KBioGR_001271; KBioSS_001558; 5-25-15-00338 (Beilstein Handbook Reference); KSC679I2B; MLS002473300; Allantoin, analytical standard; Bio-0219; DivK1c_000281; SPECTRUM1500801; SPBio_000237; SPBio_001924; BPBio1_000005; CHEMBL593429; 5-Ureido-2,4-imidazolidindione; DTXSID3020043; CTK5H9420; HMS500O03; KBio1_000281; KBio2_001558; KBio2_004126; KBio2_006694; KBio3_002051; Allantoin, >=98.0% (N); MolPort-001-779-876; NINDS_000281; Urea,5-dioxo-4-imidazolidinyl)-; HMS1568A05; HMS1921I10; HMS2092K16; HMS2095A05; HMS2268N08; Pharmakon1600-01500801; component of Skin-balm (Salt/Mix); HY-N0543; NSC-7606; 2,5-Imidazolidinedione, 4-ureido-; Tox21_110395; Tox21_202087; Tox21_302912; ANW-43029; BBL027508; CCG-39781; NSC757792; SBB003997; STL373778; AKOS000120642; AKOS016038547; Tox21_110395_1; CS-7741; LS-7181; MCULE-1008326286; NSC-757792; RL06095; RTR-038622; SDCCGMLS-0066595.P001; 1-(2,5-Dioxoimidazolidin-4-yl);urea; IDI1_000281; KS-0000005S; Allantoin, p.a., 98.5-101.0%; N-(2,5-Dioxo-4-imidazolidinyl)urea #; NCGC00094854-01; NCGC00094854-02; NCGC00094854-03; NCGC00094854-04; NCGC00094854-05; NCGC00094854-07; NCGC00256403-01; NCGC00259636-01; (RS)-(2,5-dioxoimidazolidin-4-yl)urea; 4CN-0784; 5377-33-3; AC-11040; AK-77679; AN-24454; AS-13865; H736; NCI60_041675; SC-18051; N-(2,5-Dioxo-4(1h)-imidazolidinyl)urea; SBI-0051759.P002; KB-212681; ST2408512; TR-038622; A0211; AB00052307; BG01500390; FT-0604592; ST50308144; C01551; J10470; M-5668; Urea, (2,5-dioxo-4-imidazolidinyl)- (9CI); AB00052307_11; I05-0376; J-522839; SR-01000766252-2; SR-01000766252-3; SR-01000766252-4; W-100104; I14-13401; Allantoin, European Pharmacopoeia (EP) Reference Standard; A999F0D6-0285-41D9-A6BA-B705987B663C; Allantoin, United States Pharmacopeia (USP) Reference Standard; Allantoin, Pharmaceutical Secondary Standard; Certified Reference Material; Ao>>u(1/4)a paragraph signthorn-micro feminineA Ie-2,4- paragraph signthornI feminine; 37305-69-4; 5-Ureidohydantoin; Glyoxyldiureide; Glyoxylic diureide; Cordianine; Glyoxyldiureid; (2,5-Dioxo-4-imidazolidinyl)urea; 58308-55-7; Allantoin; Herpecin L; Herpecin-L; HerpecinL; Sebical; Woun’dres; 5-Ureidohydantoin, Glyoxylic(acid) diureide; (2,5-DIOXO-4-IMIDAZOLIDINYL) – UREA; (2,5-DIOXO-4-IMIDAZOLIDINYL) UREA; 5-UREIDOHYDANTOIN; GLYOXYLDIUREID; GLYOXYLDIUREIDE; GLYOXYLIC DIUREIDE; UREA, (2,5-DIOXO-4-IMIDAZOLIDINYL) -; UREA, (2,5DIOXO4IMIDAZOLIDINYL) ; (2,5-DIOXO-4-IMIDAZOLIDINYL) UREA; 5-UREIDOHYDANTOIN; AI3-15281; (±)-Allantoin; (±)-Allantoin; 1-(2,5-Dioxo-4-imidazolidinyl)harnstoff [German] [ACD/IUPAC Name]; 1-(2,5-Dioxo-4-imidazolidinyl)urea [ACD/IUPAC Name]; 1-(2,5-Dioxo-4-imidazolidinyl)urée [French] [ACD/IUPAC Name]; 1-(2,5-Dioxoimidazolidin-4-yl)harnstoff; 1-(2,5-dioxoimidazolidin-4-yl)urea; 2,5-Dioxo-4-imidazolidinyl-urea; 202-592-8 [EINECS]; 344S277G0Z; 39669-95-9 [RN]; 4H-imidazole-2,5-diol, 4-[(hydroxyiminomethyl)amino]-; 4-ureido-2,5-Imidazolidinedione; 5-Ureido-2,4-imidazolidindion; 5-ureido-Hydantoin; 97-59-6 [RN]; Allantoin [BAN] [JAN] [USAN] [USP] [Wiki]; Allantoin (8CI); DL-Allantoin; N-(2,5-Dioxo-4-imidazolidinyl)urea; UNII:344S277G0Z; Urea, (2,5-dioxo-4-imidazolidinyl)-; Urea, (2,5-dioxo-4-imidazolidinyl)- (9CI); Urea, N-(2,5-dioxo-4-imidazolidinyl)- [ACD/Index Name]; 5-Ureidohydrantoin; Fancol TOIN; (2,5-diketoimidazolidin-4-yl)urea; (2,5-dioxo-4-imidazolidinyl)-urea; (2,5-Dioxo-4-imidazolidinyl)urea; (2,5-dioxoimidazolidin-4-yl)urea; (2,5-Dioxo-imidazolidin-4-yl)-urea; (RS)-(2,5-dioxoimidazolidin-4-yl)urea; [97-59-6]; 2,5-dioxoimidazolidin-4-ylurea; 2,5-Imidazolidinedione, 4-ureido-; 5-Ureido-2,4-imidazolidindione; 5-Ureido-2,4-imidazolidinedione; Actinac; Alantan; Allantoi; allantoin 98%; Allantoin CTFA; allantoin standard; allantoin, ???; allantoin, 98%; allantoin, powder; Allantoinum; Allantol; Alloxantin [Wiki]; Alphosyl; amino-N-(2,5-dioxo(1,3-diazolidin-4-yl))amide; AVC/Dienestrolcream; c4h6n4o3; Cordianin; Cutemol emollient; Dermalex; DL-ALLANTOIN-5-13C,1-15N; Glyoxyldiureid; Glyoxylic diureide; Glyoxylic(acid) diureide; Hemocane; Hydantoin, 5-ureido-; MFCD00005260 [MDL number]; N-(2,5-dioxoimidazolidin-4-yl)urea; Paxyl [Wiki]; Pharmakon1600-01500801; ProClin 300; Psoralon; S-allantoin; Sebical; Septalan; Uniderm A; Urea, (2, 5-dioxo-4-imidazolidinyl)-; Ureidohydantoin.; YT1600000; ??? [Chinese]; (2,5-Dioxo-4-imidazolidinyl)urea; 2,5-Dioxo-4-imidazolidinyl-urea; 4-ureido-2,5-imidazolidinedione; 5-Ureido-2,4-imidazolidindione; 5-Ureidohydantoin; 5-ureidohydantoin; glyoxyldiureide; N-(2,5-Dioxo-4-imidazolidinyl)urea; InChI=1S/C4H6N4O3/c5-3(10)6-1-2(9)8-4(11)7-1/h1H,(H3,5,6,10)(H2,7,8,9,11); POJWUDADGALRAB-UHFFFAOYSA-N; Urea, (2,5-dioxo-4-imidazolidinyl)-; 1-(2,5-dioxoimidazolidin-4-yl)urea; Urea, (2,5-dioxo-4-imidazolidinyl)-; Allantol; AVC/Dienestrolcream; Cordianine; Glyoxyldiureid; Glyoxyldiureide; Hydantoin, 5-ureido-; Sebical; 5-Ureidohydantoin; 2,5-Dioxo-4-imidazolidinyl-urea; Alantan; Glyoxylic diureide; 5-Ureidohydrantoin; Fancol TOIN; Psoralon; Septalan; 2,5-Imidazolidinedione, 4-ureido-; NSC 7606; Urea, N-(2,5-dioxo-4-imidazolidinyl)-; allantoine>; allanton; allantone; allan ton; allan toine; allan ton; allan toin; ALLANTON; ALLANTOIN; ALLAN TOIN; ALLAN TONE; ALLAN TOINE; ALLAN TOIN; ALLANTOIN ; ALLANTON; allantoin; 97-59-6; 5-Ureidohydantoin; Glyoxyldiureide; 1-(2,5-dioxoimidazolidin-4-yl)urea; Glyoxyldiureid; Allantol; Cordianine; Sebical Alantan; AVC/Dienestrolcream; Urea, (2,5-dioxo-4-imidazolidinyl)-; Hydantoin, 5-ureido-; Cutemol emollient; Uniderm A; Glyoxylic diureide; (2,5-Dioxo-4-imidazolidinyl)urea; Psoralon; Septalan; Caswell No. 024; (2,5-dioxoimidazolidin-4-yl)urea; Glyoxylic(acid) diureide; 5-Ureido-2,4-imidazolidindion; NSC 7606; Ureidohydantoin; Allantoi; CCRIS 1958; Allantoin [USAN:BAN]; Fancol TOIN; 5-Ureidohydrantoin; N-(2,5-Dioxo-4-imidazolidinyl)urea; EPA Pesticide Chemical Code 085701; AI3-15281; NSC7606; 2,5-Dioxo-4-imidazolidinyl-urea; Allantoin (JAN/USP); EINECS 202-592-8; BRN 0102364; urea, N-(2,5-dioxo-4-imidazolidinyl)-; MLS000737882; C4H6N4O3; CHEBI:15676; 4-ureido-2,5-Imidazolidinedione; POJWUDADGALRAB-UHFFFAOYSA-N; MFCD00005260; N-(2,5-dioxoimidazolidin-4-yl)urea; DSSTox_CID_43; Herpecin L; D00121; DSSTox_RID_75334; DSSTox_GSID_20043; (S)-Allantoin; N-[2,5-dioxoimidazolidin-4-yl]urea; 5377-33-3; SMR000528073; amino-N-(2,5-dioxo(1,3-diazolidin-4-yl))amide; allantion; Allantoinum; Hemocane; DL-Allantoin; Allantoin CTFA; HSDB 7490; Allantoin [USAN:USP:BAN:JAN]; CAS-97-59-6; Prestwick_11; NCGC00016358-01; 5-ureido-Hydantoin; Allantoin (8CI); 5-eaAoAOEO; (+/-)-Allantoin; Spectrum_001078; ACMC-209twn; Prestwick0_000002; Prestwick1_000002; Prestwick2_000002; Prestwick3_000002; Spectrum2_000219; Spectrum3_000876; Spectrum4_000716; Spectrum5_001526; bmse000437; D01HNL; AC1L18PM; AC1Q2AJ8; SCHEMBL3208; Oprea1_621175; Allantoin, 98% 250g; BSPBio_000003; BSPBio_002551; KBioGR_001271; KBioSS_001558; 5-25-15-00338 (Beilstein Handbook Reference); RSC679I2B; MLS002473300; Allantoin, analytical standard; Bio-0219; DivK1c_000281; SPECTRUM1500801; SPBio_000237; SPBio_001924; BPBio1_000005; CHEMBL593429; 5-Ureido-2,4-imidazolidindione; DTXSID3020043; CTK5H9420; HMS500O03; KBio1_000281; KBio2_001558; KBio2_004126; KBio2_006694; KBio3_002051; Allantoin, >=98.0% (N); MolPort-001-779-876; NINDS_000281; Urea,5-dioxo-4-imidazolidinyl)-; HMS1568A05; HMS1921I10; HMS2092K16; HMS2095A05; HMS2268N08; Pharmakon1600-01500801; component of Skin-balm (Salt/Mix); HY-N0543; NSC-7606; 2,5-Imidazolidinedione, 4-ureido-; Tox21_110395; Tox21_202087; Tox21_302912; ANW-43029; BBL027508; CCG-39781; NSC757792; SBB003997; STL373778; AKOS000120642; AKOS016038547; Tox21_110395_1; CS-7741; LS-7181; MCULE-1008326286; NSC-757792; RL06095; RTR-038622; SDCCGMLS-0066595.P001; 1-(2,5-Dioxoimidazolidin-4-yl);urea; IDI1_000281; KS-0000005S; Allantoin, p.a., 98.5-101.0%; N-(2,5-Dioxo-4-imidazolidinyl)urea #; NCGC00094854-01; NCGC00094854-02; NCGC00094854-03; NCGC00094854-04; NCGC00094854-05; NCGC00094854-07; NCGC00256403-01; NCGC00259636-01; (RS)-(2,5-dioxoimidazolidin-4-yl)urea; 4CN-0784; AC-11040; AK-77679; AN-24454; AS-13865; BT000187; H736; HE033953; HE331747; HE420345; HE420346; NCI60_041675; SC-18051; N-(2,5-Dioxo-4(1h)-imidazolidinyl)urea; SBI-0051759.P002; KB-212681; ST2408512; TR-038622; A0211; AB00052307; FT-0604592; ST50308144; C01551; J10470; M-5668; Urea, (2,5-dioxo-4-imidazolidinyl)- (9CI); AB00052307_11; SR-01000766252; I05-0376; J-522839; SR-01000766252-2; W-100104; I14-13401; Allantoin, European Pharmacopoeia (EP) Reference Standard; A999F0D6-0285-41D9-A6BA-B705987B663C; Allantoin, United States Pharmacopeia (USP) Reference Standard; Allantoin, pharmaceutical secondary standard; traceable to USP and PhEur; Ao>>u(1/4)a paragraph signthorn-micro feminineA Ie-2,4- paragraph signthornI feminine; 37305-69-5-; Ureidohydantoin; Glyoxyldiureide; Glyoxylic diureide; Cordianine; Glyoxyldiureid; (2,5-Dioxo-4-imidazolidinyl)urea; 58308-55-7; Glyoxyldiureide; 5-Ureidohydantoin; (2,5-DIOXO-4-IMIDAZOLIDINYL) – UREA; (2,5-DIOXO-4-IMIDAZOLIDINYL) UREA; 5-UREIDOHYDANTOIN; GLYOXYLDIUREID; GLYOXYLDIUREIDE; GLYOXYLIC DIUREIDE; UREA, (2,5-DIOXO-4-IMIDAZOLIDINYL) -; UREA, (2,5DIOXO4IMIDAZOLIDINYL); (2,5-DIOXO-4-IMIDAZOLIDINYL) UREA; 5-UREIDOHYDANTOIN; 102364; C4H6N4O3; POJWUDADGALRAB-UHFFFAOYSA-N; ?98%; 5-Ureidohydantoin; Glyoxylic(acid) diureide; MFCD00005260; 202-592-8; Allantoin, ?98.0% (N); Allantoin, analytical standard; Allantoin, European Pharmacopoeia (EP) Reference Standard; Allantoin, Pharmaceutical Secondary Standard; Certified Reference Material; Allantoin, United States Pharmacopeia (USP) Reference Standard; 5-Ureidohydantoin; Glyoxylic(acid) diureide; analytical standard; InChI KeyPOJWUDADGALRAB-UHFFFAOYSA-N; assay?98.0% (HPLC); 5397; ChEBI:15678; ChEMBL:CHEMBL1230080; PDB-CCD:3AL[PDBj]; 3DMET:B00428; NIKKAJI:J732.396D; FormulaC4H6N4O3; Exact mass 158.044; Mol weight158.1154; ALLANTON; ALLANTONE; ALLANTOINE; ALLANTOIN; allantone; allantoine; allantoin; allanton; allanton; allantan; allantaina; allantana; ALLONTON; allonton; allontoin; ALLONTOYIN; ALLONTOYN; allontoyn; allontoyin; (2,5-Dioxo-4-imidazolidinyl) urea; GLYOXYLDIUREIDE; glyoxyldurede; Glyoxyldiureide; gloksldure; gloksildiüre; GLOKSILDIURE; GLOKSLDÜRE; 5 UREIDOHYDANTOIN; 5 UREDOHYDANTON; 5 uredohydanton; 5 üreidohydantoin; 5-Ureidohydantoin; ALANTONE; ALANTON; ALLANTON; ALANTON; ALLANTaOIN; ALANTOIN; ALLANTONE; ALLANTONE; allantoine; allantoin; alantoin; alanton; allantoine; allantone; alantoine; allantoine; alanton; alanton; allanton; allantoin; allantoyin; alantoyin; allantoyne; allantoyn; allantoyin; allantoine; allantoyn; alantoyn; allatoyin; allantoyn; allantone; alantoyin; alantoyine; alantoyine;
The skin is a natural actor proven to be refreshing and protective.
The US Food and Drug Administration (FDA) classified Allantoin as Category 1 (safe and effective) as a skin protector.
Although the working mechanism of Allantoin as a cosmetic raw material is still unclear, value and efficacy have been supported by many in-vitro and in-vivo tests
Even when allantoin is used at 0.3%, it is a highly effective anti-inflammatory. Because it is both effective and economical, it is widely used in over-the-counter topical formulations and cosmetic products.
Allantoin is used to promote natural renewal of the skin, to prevent irritation, to improve moisture retention capacity and to soften the skin.
Description
Allantoin is a substance that is endogenous to the human body and also found as a normal component of human diets [FDA Label]. In healthy human volunteers, the mean plasma concentration of allantoin is about 2-3 mg/l. During exercise, the plasma allantoin concentration rapidly increases about two fold and remains elevated [FDA Label]. In human muscle, urate is oxidized to allantoin during such exercise [FDA Label]. The concentration of allantoin in muscles increases from a resting value of about 5000 ug/kg to about 16000 ug/kg immediately after short-term exhaustive cycling exercise [FDA Label].
More specifically, allantoin is a diureide of glyoxylic acid that is produced from uric acid. It is a major metabolic intermediate in most organisms. Allantoin is found in OTC cosmetic products and other commercial products such as oral hygiene products, in shampoos, lipsticks, anti-acne products, sun care products, and clarifying lotions . Allantoin has also demonstrated to ameliorate the wound healing process in some studies
What it is ?
Allantoin is a white powder. It can be found in plants, like comfrey and horse chestnut, and in the urine of most mammals. The type that is most commonly used in cosmetics and skincare products though derives from urea and glyoxylic acid.
What it does ?
Allantoin has anti-irritant, soothing and healing properties: it calms down irritations, helps shed the upper layers of dead skin cells and promotes the growth of healthy tissue. That’s why it’s effective at treating wounds,eczema, psoriasis, burns and other skin conditions.
Uses
Allantoin is useful for the treatment of wound, carbuncles, burns and sunburns, scalds, acne and skin eruptions, impetigo, psoriasis, eczema, fissures and abrasions.
Allantoin is an anti-aging ingredient used in facial rejuvenation products. It is a common ingredient of skin care products. It is proven effective in soothing irritated skin, stimulates cell regeneration and moisturizes dry skin.
In harnessing the effectiveness and benefits of allantoin, it is used in various facial cleaners, acne products, toners, sunscreens, moisturizers, and other specialty skin care products.
The derivatives of allantoin brought about personal care products such as follows:
• Deodorants and antiperspirants
• Shaving products
• Skin-astringent lotions
• Anti-Acne
• Foot preparations products
• Veterinary preparations products
• Dusting powder and cream
• Hair care products
• Anti-inflammatory products
Allantoin is a chemical compound with formula C4H6N4O3. It is also called 5-ureidohydantoin or glyoxyldiureide.[1][2] It is a diureide of glyoxylic acid. Allantoin is a major metabolic intermediate in most organisms including animals, plants and bacteria. It is produced from uric acid, which itself is a degradation product of nucleic acids, by action of urate oxidase (uricase).
History
Allantoin was first isolated in 1800 by the Italian physician Michele Francesco Buniva (1761-1834) and the French chemist Louis Nicolas Vauquelin, who mistakenly believed it to be present in the amniotic fluid.[6] In 1821, the French chemist Jean Louis Lassaigne found it in the fluid of the allantois; he called it “l’acide allantoique”.[7] In 1837, the German chemists Friedrich Wöhler and Justus Liebig synthesized it from uric acid and renamed it “allantoïn”.
Animals
Named after the allantois (an amniote embryonic excretory organ in which it concentrates during development in most mammals except humans and other higher apes), it is a product of oxidation of uric acid by purine catabolism. After birth, it is the predominant means by which nitrogenous waste is excreted in the urine of these animals.[9] In humans and other higher apes, the metabolic pathway for conversion of uric acid to allantoin is not present, so the former is excreted. Recombinant rasburicase is sometimes used as a drug to catalyze this metabolic conversion in patients. In fish, allantoin is broken down further (into ammonia) before excretion.
Allantoin has been shown to improve insulin resistance when administered to rats and increased lifespan when administered to the nematode worm Caenorhabditis elegans.
Bacteria
In bacteria, purines and their derivatives (such as allantoin) are used as secondary sources of nitrogen under nutrient-limiting conditions. Their degradation yields ammonia, which can then be utilized.[13] For instance, Bacillus subtilis is able to utilize allantoin as its sole nitrogen source.
Mutants in the B. subtilis pucI gene were unable to grow on allantoin, indicating that it encodes an allantoin transporter.
In Streptomyces coelicolor, allantoinase (EC 3.5.2.5) and allantoicase (EC 3.5.3.4) are essential for allantoin metabolism. In this species the catabolism of allantoin, and the subsequent release of ammonium, inhibits antibiotic production (Streptomyces species synthesize about half of all known antibiotics of microbial origin).
Applications
Allantoin is present in botanical extracts of the comfrey plant and in the urine of most mammals. Chemically synthesized bulk allantoin, which is chemically equivalent to natural allantoin, is safe, non-toxic, compatible with cosmetic raw materials and meets CTFA and JSCI requirements. Over 10,000 patents reference allantoin.
Cosmetics and toiletries
Manufacturers cite several beneficial effects for allantoin as an active ingredient in over-the-counter cosmetics, including: a moisturizing and keratolytic effect, increasing the water content of the extracellular matrix and enhancing the desquamation of upper layers of dead skin cells, increasing the smoothness of the skin; promoting cell proliferation and wound healing; and a soothing, anti-irritant, and skin protectant effect by forming complexes with irritant and sensitizing agents.
An animal study in 2010 found that based on the results from histological analyses, a soft lotion with 5% allantoin ameliorates the wound healing process, by modulating the inflammatory response. The study also suggests that quantitative analysis lends support to the idea that allantoin also promotes fibroblast proliferation and synthesis of the extracellular matrix.
A study published in 2009 reported the treatment of pruritus in mild-to-moderate atopic dermatitis with a topical nonsteroidal agent containing allantoin.
Pharmaceuticals
It is frequently present in toothpaste, mouthwash, and other oral hygiene products, in shampoos, lipsticks, anti-acne products, sun care products, and clarifying lotions, various cosmetic lotions and creams, and other cosmetic and pharmaceutical products.
Well recognized skin protectant agent with keratolytic, moisturizing, soothing and healing properties. Natural-identical to the allantoin found in comfrey (Symphytum officinale), it is an extremely safe ingredient with no reports of adverse reactions over a long use history. Compatible with cosmetic raw materials, it meets requirements.
Allantoin enhances the performance of personal care formulations also at low levels, giving a smooth and healthy appearance to intact skin. Used on injuried skin it helps relief from pain and promotes cell-proliferation. Useful in all cosmetic and dermopharmaceutical applications for adults, children and infants, also as only active ingredient.
Uses
This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper rash, skin burns from radiation therapy). Emollients are substances that soften and moisturize the skin and decrease itching and flaking. Some products (e.g., zinc oxide, white petrolatum) are used mostly to protect the skin against irritation (e.g., from wetness).
Dry skin is caused by a loss of water in the upper layer of the skin. Emollients/moisturizers work by forming an oily layer on the top of the skin that traps water in the skin. Petrolatum, lanolin, mineral oil and dimethicone are common emollients. Humectants, including glycerin, lecithin, and propylene glycol, draw water into the outer layer of skin. Many products also have ingredients that soften the horny substance (keratin) that holds the top layer of skin cells together (including urea, alpha hydroxy acids such as lactic/citric/glycolic acid, and allantoin). This helps the dead skin cells fall off, helps the skin keep in more water, and leaves the skin feeling smoother and softer.
How to use Allantoin Cream
Use this product as directed. Some products require priming before use. Follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.
Some products need to be shaken before use. Check the label to see if you should shake the bottle well before using. Apply to the affected areas of the skin as needed or as directed on the label or by your doctor. How often you apply the medication will depend on the product and your skin condition. To treat dry hands, you may need to use the product every time you wash your hands, applying it throughout the day.
If you are using this product to help treat diaper rash, clean the diaper area well before use and allow the area to dry before applying the product.
If you are using this product to help treat radiation skin burns, check with radiation personnel to see if your brand can be applied before radiation therapy.
Follow all the directions on the label for proper use. Apply to the skin only. Avoid sensitive areas such as your eyes, inside your mouth/nose, and the vaginal/groin area, unless the label or your doctor directs you otherwise. Check the label for directions about any areas or types of skin where you should not apply the product (e.g., on the face, any areas of broken/chapped/cut/irritated/scraped skin, or on a recently shaved area of the skin). Consult your doctor or pharmacist for more details.
Use this medication regularly to get the most benefit from it. Most moisturizers need water to work well. Apply the product after bathing/showering while the skin is still damp. For very dry skin, your doctor may instruct you to soak the area before using the product. Long, hot, or frequent bathing/washing can worsen dry skin.
If your condition persists or worsens, or if you think you may have a serious medical problem, seek immediate medical attention.
Biomarker of oxidative stress
Since uric acid is the end product of the purine metabolism in humans, only non-enzymatic processes with reactive oxygen species will give rise to allantoin, which is thus a suitable biomarker to measure oxidative stress in chronic illnesses and senescence.
Side Effects
Most emollients can be used safely and effectively with no side effects. However, burning, stinging, redness, or irritation may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
If your doctor has prescribed this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if any of these unlikely but serious side effects occur: unusual changes in the skin (e.g., turning white/soft/soggy from too much wetness), signs of skin infection.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Precautions
Before using this product, tell your doctor or pharmacist if you are allergic to any of the ingredients in the product; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
If you have any of the following health problems, consult your doctor or pharmacist before using this product: skin cuts/infections/sores.
Some ingredients (e.g., preservatives, fragrance) may make you more sensitive to the sun. Check the label for any warnings or ask your doctor or pharmacist if you need to take any special precautions when in the sun. Your doctor/pharmacist may suggest that you limit your time in the sun, avoid tanning booths and sunlamps, and use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.
Some products may worsen acne. If your skin is prone to acne breakouts, look for the word “non-comedogenic” (will not clog pores) on the label. Some products may stain/discolor clothing. Ask your doctor or pharmacist for more details.
It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding, especially if you are applying this product to the breast area.
Interactions
If you are using this product under your doctor’s direction, your doctor or pharmacist may already be aware of possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.
If your doctor has directed you to use this product, or if you use any prescription product on the skin, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, including other skin care products.
Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
Overdose
This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Notes
Some ways to help prevent dry skin include using lukewarm (not hot) water when bathing, taking baths/showers less often (e.g., every 1-2 days), keeping baths/showers short, and using a humidifier when the air is very dry.
There are many types of emollient products available. Some contain fragrance or other ingredients that some people may be sensitive to. Emollients are available in different forms such as oils, creams, lotions, or sprays. Consult with your doctor or pharmacist on the product that may be best for you.
Missed Dose
If you are using this product on a regular schedule and miss a dose, use it as soon as you remember. Do not use more product or use it more often than directed to catch up.
Storage
Refer to storage information printed on the package. If you have any questions about storage, ask your pharmacist. Keep all drug products away from children and pets.
Do not store the foam canister near high heat (more than 120 degrees F/49 degrees C), and do not store or use it near an open flame. Because foam canisters are under pressure, do not puncture or burn the canister.
Benefits
■ Cell proliferation and regeneration
■ Skin soothing
■ Anti-inflammatory
■ Skin moisturizing
■ Anti-acne
■ Antioxidant
■ Anti-transpirant
■ INCI: Allantoin
■ CAS No.: 97 – 59 – 6
■ Appearance: White powder
■ Active content: Min. 98.6%
■ pH (0.5% aq. solution, 20°C): 4.0 – 6.0
■ Recommended usage level: 0.1 – 0.5% w/w
■ Compatible with most cosmetic ingredients
■ Adaptive in O/W and W/O emulsions and hydrogels
Allantoin is a substance that is endogenous to the human body and also found as a normal component of human diets Label. In healthy human volunteers, the mean plasma concentration of allantoin is about 2-3 mg/l. During exercise, the plasma allantoin concentration rapidly increases about two fold and remains elevated Label. In human muscle, urate is oxidized to allantoin during such exercise Label. The concentration of allantoin in muscles increases from a resting value of about 5000 ug/kg to about 16000 ug/kg immediately after short-term exhaustive cycling exercise Label.
More specifically, allantoin is a diureide of glyoxylic acid that is produced from uric acid. It is a major metabolic intermediate in most organisms. Allantoin is found in OTC cosmetic products and other commercial products such as oral hygiene products, in shampoos, lipsticks, anti-acne products, sun care products, and clarifying lotions 4. Allantoin has also demonstrated to ameliorate the wound healing process in some studies.
Allantoin is commonly applied in a variety of topical vehicles or applications such as cosmetic creams, toothpastes, mouthwashes, shampoos, lipsticks, anti-acne products, and lotions 4 for the purpose of moisturizing skin, enhancing the smoothness of skin, stimulating the healing of wounds, and soothing irritated skin.
There is no well controlled and appropriate data that can formally substantiate the pharmacodynamic properties of allantoin Label. Nevertheless, ongoing studies suggest that allantoin possesses moisturizing and keratolytic effects, as well as abilities to increase the water content of the extracellular matrix and enhance the desquamation of upper layers of dead skin cells, all of which are activities that can promote cell proliferation and facilitate wound healing 1.
Mechanism of action
There is no well controlled data that can formally substantiate the method of action Label. However, ongoing studies suggest that there may exist a histological wound healing profile induced by allantoin in rats that leads to the amelioration and fastening of the reestablishment of normal skin 1. This facilitation of wound healing is supported by observations that wounds inflicted to rat subjects to which topical allantoin preparations were applied histologically demonstrated increased vasodilation, presence of inflammatory exudates, number of inflammatory cells, angiogenesis, fibroblast proliferation, and increased collagen deposition when compared to rat subjects with wounds that did not receive any allantoin administration.
Absorption
In studies on human subjects, a recovery of 19% and 34% of allantoin in the urine was observed but only in two individuals and only after the administration of massive doses of allantoin 5. After intravenous administration, recovery in the urine was practically quantitative with doses of 75 to 600 mgm in the human model 5. After 240 mgm, excretion continued for 72 hours in human subjects and the results were similar in regards to subcutaneous injection 5.
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Uricase is the enzyme that possesses the functionality to convert uric acid to allantoin. Considering humans do not possess any endogenous uricase, uric acid is the only final breakdown product in the purine degradation of unwanted waste product purine nucleotides 5. The presence of allantoin in human urine is subsequently the result of non-enzymatic processes on uric acid with reactive oxygen species 3. Such non-enzymatic processes are consequently potentially suitable biomarkers for measuring oxidative stress in chronic illnesses and aging 3. Furthermore, as allantoin is found endogenously and is part of basic, natural metabolic pathways, no accumulation is expected of it Label. Additionally, allantoin is not believed to be metabolized to a measurable extent in humans and animals Label.
Route of elimination
Urinary clearance is the predominant excretion route Label.
Half-life
When studied in cattle, sheep, and horses, the half-life of allantoin is in the range of 1 to 2.5 hours Label.
Clearance
Some studies suggest that the average renal clearance of allantoin in normal, healthy human subjects is approximately 123 cc per minute 2. It is generally agreed upon that exogenously administered allantoin is rapidly excreted Label.
Adverse Effects
Learn about our commercial Adverse Effects data.
Toxicity
No studies on repeated dose toxicity and reproductive toxicity have been submitted. Moreover, studies show that the tumor incidence in allantoin treated animals did not differ largely from that found in untreated controls. As a result, further or additional toxicity, mutagenicity, or carcinogenicity tests are not required in view of the endogenous nature of allantoin and the general lack of overall toxicity Label.
Finally, as allantoin is a normal component of the diet in humans and is a substance of endogenous origin present in the body of humans, it is generally recognized as being a safe substance for humans Label.
Affected organisms
Humans and other mammals
Allantoin;
Cildi yenileyici ve koruyucu etkisi kantlanm doal bir aktiftir.
ABD Gda ve laç Dairesi (FDA) Allantoin’i Kategori 1 (güvenli ve etkili) de cilt koruyucu olarak snflandrmtr.
Bir kozmetik hammadde olarak Allantoin’in çalma mekanizmas hala net olarak anlalamam olmasna ramen, deeri ve etkinlii yaplan birçok in-vitro ve in-vivo testlerle desteklenmitir
Allantoin %0,3 kullanldnda bile oldukça etkili bir anti inflamatuardr. Hem etkisi hem de ekonomik olmas nedeniyle, reçetesiz topikal formülasyonlarda ve kozmetik ürünlerde yaygn olarak kullanlr.
Allantoin, cildin doal yenilenmesi desteklemek, tahri olmasn önlemek, nem tutma kapasitesini gelitirmek ve cildi yumuatmak için kullanlr.
Açklama
Allantoin insan vücuduna endojen olan ve ayn zamanda insan diyetlerinin normal bir bileeni olan [FDA Label] bir maddedir. Salkl insan gönüllülerinde, ortalama plazma plazma konsantrasyonu yaklak 2-3 mg / l’dir. Egzersiz srasnda, plazma allantoin konsantrasyonu hzla iki kat artar ve yüksek kalr [FDA Label]. nsan kasnda, bu egzersiz srasnda urat allantoine oksitlenir [FDA Label]. Kaslardaki allantoin konsantrasyonu, ksa süreli ar bisiklet egzersizinden [FDA Label] hemen sonra yaklak 5000 ug / kg ila yaklak 16000 µg / kg dinlenme deerinden artar.
Daha spesifik olarak, allantoin, ürik asitten üretilen bir glioksilik asit diüritidir. Çou organizmada önemli bir metabolik ara madde. Allantoin, OTC kozmetik ürünlerinde ve az hijyeni ürünleri, ampuanlar, rujlar, anti-akne ürünleri, güne bakm ürünleri ve arndrc losyonlar gibi dier ticari ürünlerde bulunur. Allantoin ayrca baz çalmalarda yara iyileme sürecini iyiletirdiini göstermitir.
Nedir ?
Allantoin beyaz bir tozdur. Karakafes ve at kestanesi gibi bitkilerde ve çou memelinin idrarnda bulunabilir. Kozmetik ve cilt bakm ürünlerinde en çok kullanlan tip, üre ve glioksilik asittir.
Ne yapar ?
Allantoin anti-tahri edici, yattrc ve iyiletirici özelliklere sahiptir: tahrileri yattrr, ölü deri hücrelerinin üst katmanlarn dökmeye yardmc olur ve salkl dokunun büyümesini destekler. Bu yüzden yaralarn, egzamalarn, sedeflerin, yanklarn ve dier cilt hastalklarnn tedavisinde etkilidir.
Kullanmlar
Allantoin, yara, carbuncles, yanklar ve sunburns, scalds, akne ve cilt döküntüleri, impetigo, sedef, egzama, çatlak ve syrklarn tedavisi için yararldr.
Allantoin yüz gençletirme ürünlerinde kullanlan yalanma kart bir maddedir. Cilt bakm ürünlerinin ortak bir maddesidir. Tahri olmu cildin yattrlmasnda etkilidir, hücre rejenerasyonunu uyarr ve kuru cildi nemlendirir.
Allantoinin etkililiini ve yararlarn deerlendirirken, çeitli yüz temizleyicileri, akne ürünleri, tonerler, güne kremleri, nemlendiriciler ve dier özel cilt bakm ürünlerinde kullanlr.
Allantoin türevleri aadaki gibi kiisel bakm ürünleri getirdi:
• Deodorantlar ve antiperspirantlar
• Tra ürünleri
• Cilt-büzücü losyonlar
• Sivilce Kart
• Ayak preparatlar ürünleri
• Veteriner preparatlar ürünleri
• Toz alma tozu ve kremi
• Saç bakm ürünleri
• Anti-inflamatuar ürünler
Allantoin, birçok popüler cilt bakm ürününde bulunan ve yaygn olarak kullanlan bir bileendir. Ayrca, cilde iyi gelen kimyasal bir bileik olarak çok yönlü bileenlerden biridir.
Genellikle karakafes bitkisinin (Symphytum Officinale) köklerinde bulunan bitkisel özlerden, aloe vera, papatya, lotus, yam ve dier bitkilerden gelir.
Kullanm eski Msr ve Çin’e kadar uzanyor. Bir bileen olarak; kimyasal bileiminin herhangi bir yan etkisi olmad ve tüm cilt tipleri için geçerli olduu, cilde uygulandnda da güvenli olduu bilinmektedir.
Allantoin’in, cildi yumuatmak ve nemlendirmek dahil olmak üzere birçok farkl yarar olan çok yönlü, güvenli ve etkili bir cilt bakm bileeni olduunu söyleyebiliriz. International Toxicology dergisine göre allantoin, çeitli kozmetik uygulamalarnda kullanm için toksik olmayan ve güvenli olduu tespit edilmi bir bileendir.
ALLANTON ETK MEKANZMASI NASILDIR?
Allantoin bilinen bir keratolitiktir, yani hücrelerin su içeriini artrabilir. Ayn zamanda cildin d katmanlarnn iaretlenmesinde de yardmc olur.
Keratolitik özellik; özellikle siil, akne, kepek ve sedef hastal (psoriazis) gibi cilt ve saç deri bozukluklarn tedavi etmekte kullanlr. Keratolitik etki, koruyucu ve düzenleyici ilevlerini yerine getiren, cildimizin d tabakas epidermdir. Stratum Korneum’da doal olarak bulunan çok sayda protein ve yalar (lipitler) sentezler.
Allantoin aklldr; anormal ve kaln bir Stratum Korneum’u inceltmek için cildin keratiniyle etkileime girer. Bu durum, allantoinin cildinizi pürüzsüz hissetmeniz için salad özelliktendir. Cildinizde kullanacanz %0,2 deriim orannda bir allantoin, keratolitik özellikte olmaktadr. Allantoin düük konsantrasyonlarda (%0,5’e kadar) çok aktiftir ve en büyük avantaj cildi tahri edici olmamas ve toksik olmamasdr.
ALLANTON BLMSEL ÇALIMALARI NELERDR?
Allantoin’in, cildin kendini iyiletirip yenilemesi konusunda etkili olduu da bilinmektedir. Liverpool Üniversitesi tarafndan yaplan 2015 aratrmas, Allantoin’in cilt bakm ürünleri yoluyla sunduu faydal özelliklerini ve bilimsel ilevlerini dorulamtr.
Allantoin ile ilgili bir çalmaya göre; sadece% 0.2’lik bir Allantoin orann bulunduu bileen sayesinde, kadnlarn cildinde kzarklk ve çatlama belirtileri %90 oranndan fazla düzelmitir. Allantoinin aktif keratolitik özelliklere sahip olmas, kepekle mücadelede ideal bir bileen olduu anlamna gelir ve bunu ölü cilt hücrelerinde büyük parçacklar parçalayarak yapar.
ALLANTON’N CLT ÇN FAYDALARI NELERDR?
Allantoin’de bulunan bileikler hakknda oldukça fazla aratrma yaplmtr. Buna göre Allantoin’in cilt için faydalarn u ekilde sralayabiliriz.
Cildi Nemlendirir
Allantoin, cildin su içeriini arttrr.
Desquamation (deskuamasyon)
Derinin d tabakas olan Stratum Corneum’da doal dökülmeyi tevik eder.
Onarc Etki
Yeni doku büyümesini tevik ederek hücre çoalmasn uyarma kabiliyeti ile bilinir. Hücrelerin yenilenmesini tevik eder. Yara iyilemesi üzerine yaplan bilinen aratrmalar, nekrotik yara dokusunu temizlediini ve salkl yeni bir dokuya yol açtn göstermitir.
yileme
Aktif bir cilt koruyucudur, doal olarak ciltlerin iyileme sürecini tevik eder. Küçük yaralarn ve tahrilerin tedavisi için uygun bir bileendir.
Cilt Kuruluunu Hafifletir
Hücresel yenilenmeyi tevik eder, kuruluu önler ve hassas cildi daha esnek olmaya tevik eder.
Koruma
Cildi gerçekten yumuatan bir bileendir. Çatlam, günete hasar görmü cildi korur. Yaplan çalmalar, Allantoin’in UV kaynakl hücre hasarna kar koruduunu göstermitir.
Yattrc
Mükemmel bir yattrc olarak kabul edilir. Bu yüzden bebek ürünlerinde bile tahrii önlemek amaçl kullanlr.
Yalanma Kart ve Antioksidan Etki
Allantoin, topikal uygulamas sayesinde ciltte serbest radikal aktivitenin azaltlmasna yardmc olur.
Allantoin içerikli ürünleri kimler özellikle kullanmaldr?
Allantoin, dier birçok nemlendiriciden farkl olarak kimyasal ve fiziksel olarak etki etmesine ramen bazen bir nemlendirici olarak kabul edilir. Susuz kalm kuru ciltler için, cildin yumuatlmas ve daha fazla nemi emmesi için yattrc özellikleri ile skça karlalr. Cildin yenilenme sürecini artrmak için, vücudunuzun cildin üst katmanlarndaki ölü cilt hücrelerini daha yumuak ve pürüzsüz hale getirmesine yardmc olur. Bir bileik olarak Allantoin, ölü cilt hücreleri ve keratin gibi engelleri ortadan kaldrr. Bu, cildin alt katmanlarnn normal olarak nemi emmesine ve krklklarn görünümünü azaltmasna yardmc olarak cildin nemlenmesini artrr. Allantoin’in anti-enflamatuar, tahri edici özellikleri ile toksik olmayan, alerjik olmayan bir bileendir.
Allantoin , formül C 4 H 6 N 4 O 3 olan kimyasal bir bileiktir . Ayn zamanda 5-üreidohidantoin veya glioksildiureid olarak da adlandrlr . [1] [2] bir olan diureide ait glioksilik asit . Allantoin, hayvanlar, bitkiler ve bakteriler dahil çou organizmada önemli bir metabolik ara maddedir. Nükleik asitlerin bozunma ürünü olan ürik asitten, ürat oksidazn (ürikaz) etkisiyle üretilir .
Tarih
Allantoin ilk olarak 1800 ylnda talyan doktor Michele Francesco Buniva (1761-1834) ve yanllkla amniyotik svda bulunduuna inanan Fransz kimyager Louis Nicolas Vauquelin tarafndan izole edildi . [6] 1821’de, Fransz kimyager Jean Louis Lassaigne sv içinde bulunan allantois ; “l’acide allantoique” adn verdi . [7] 1837’de Alman kimyagerler Friedrich Wöhler ve Justus Liebig onu ürik asitten sentezlediler ve “allantoïn” olarak yeniden adlandrdlar.
Hayvanlar
Adn allantois (bir amniyota embriyonik boaltm organ olarak en gelime srasnda konsantrelerinin , memelilerde , insan ve dier yüksek maymunlar hariç), bu oksitlenme ürünü olan ürik asit ile purin katabolizmas . Doumdan sonra, hangi baskn yoludur azotlu atk atlr idrar bu hayvanlarn. [9] nsanlarda ve dier yüksek maymunlarda, ürik asidin allantoine dönüümü için metabolik yol mevcut deildir, bu nedenle ilki atlr. Rekombinant rasburikazbazen hastalarda bu metabolik dönüümü katalize etmek için bir ilaç olarak kullanlr. Balklarda, allantoin atlmadan önce daha da parçalanr ( amonyaa ).
Allantoinin, sçanlara uygulandnda insülin direncini artrd ve Caenorhabditis elegans nematod kurdu uygulandnda yaam süresini uzatt gösterilmitir .
Bakteri
Bakterilerde pürinler ve bunlarn türevleri (allantoin gibi), besin snrlayc koullar altnda ikincil nitrojen kaynaklar olarak kullanlr. Bozulmalar, daha sonra kullanlabilen amonyak verir. [13] Örnein Bacillus subtilis , tek nitrojen kayna olarak allantoini kullanabilir.
B. subtilis pucI genindeki mutantlar , allantoin üzerinde büyüyememitir, bu da bir allantoin taycsn kodladn gösterir. [
In Streptomyces coelicolor , allantoinase ( EC 3.5.2.5) ve allantoicase (EC 3.5.3.4) metabolizmay allantoin için gereklidir. Bu türde allantoinin katabolizmas ve ardndan amonyum salnm antibiyotik üretimini engeller ( Streptomyces türleri, mikrobiyal kökenli bilinen tüm antibiyotiklerin yaklak yarsn sentezler).
Uygulamalar
Allantoin botanik mevcut olan özler arasnda karakafes bitki ve idrar en memelilerin. Kimyasal olarak doal allantoine edeer olan kimyasal olarak sentezlenmi yn allantoin, güvenli, toksik deildir, kozmetik hammaddelerle uyumludur ve CTFA ve JSCI gereksinimlerini karlar. 10.000’den fazla patent, allantoine referans verir.
Kozmetik ve tuvalet malzemeleri
Üreticiler, reçetesiz satlan kozmetiklerde aktif bir bileen olarak allantoinin birkaç yararl etkisinden bahsediyor: Nemlendirici ve keratolitik etki, hücre d matrisin su içeriini artrma ve ölü deri hücrelerinin üst katmanlarnn kireçlenmesini artrma, pürüzsüzlüü artrma derinin; hücre proliferasyonunu ve yara iyilemesini tevik etmek ; ve tahri edici ve hassaslatrc maddelerle kompleksler oluturarak yattrc, tahri önleyici ve cilt koruyucu etki.
2010 ylnda yaplan bir hayvan çalmas, histolojik analizlerden elde edilen sonuçlara dayanarak, % 5 allantoin içeren yumuak bir losyonun , enflamatuar yant modüle ederek yara iyileme sürecini iyiletirdiini bulmutur . Çalma ayrca, kantitatif analizin, allantoinin ayrca fibroblast proliferasyonunu ve hücre d matrisin sentezini destekledii fikrine destek verdiini ileri sürmektedir . [
2009’da yaynlanan bir çalmada , hafif-orta dereceli atopik dermatitte , allantoin içeren topikal nonsteroidal bir ajan ile kant tedavisi bildirilmitir .
laçlar
Di macunu , gargara ve dier az hijyeni ürünlerinde, ampuanlarda , rujlarda , akne önleyici ürünlerde, güne bakm ürünlerinde ve arndrc losyonlarda, çeitli kozmetik losyonlarda ve kremlerde ve dier kozmetik ve farmasötik ürünlerde sklkla bulunur .
Oksidatif stresin biyobelirteci
Yana ürik asit son ürünü olan purin metabolizmas , insanlarda, sadece enzimatik olmayan ilemler , reaktif oksijen türlerinin , böylece uygun bir allantoin sebebiyet verecektir biyomarker ölçmek için oksidatif stres kronik hastalklar ve yalanma .
Allantoin, birçok popüler cilt bakm ürününde bulunan ve yaygn olarak kullanlan bir bileendir. Ayrca Allantoin, cilde iyi gelen kimyasal bir bileik olarak çok yönlü bileenlerden biridir.
Kullanm eski Msr ve Çin’e kadar uzanyor. Bir bileen olarak; kimyasal bileiminin herhangi bir yan etkisi olmad ve tüm cilt tipleri için geçerli olduu, cilde uygulandnda da güvenli olduu bilinmektedir.
Faydalar;
Nemlendirici: Cildin su içeriini arttrr.
Desquamation (deskuhamasyon): Derinin d tabakas olan stratum corneum’da doal dökülmeyi tevik eder.
Onarc etki: Yeni doku büyümesini tevik ederek hücre çoalmasn uyarma kabiliyeti ile bilinir. Hücrelerin yenilenmesini tevik eder. Yara iyilemesi üzerine yaplan bilinen aratrmalar, nekrotik yara dokusunu temizlediini ve salkl yeni bir dokuya yol açtn göstermitir.
yileme: Aktif bir cilt koruyucu, doal olarak ciltlerin iyileme sürecini tevik eder; Küçük yaralarn ve tahrilerin tedavisi için uygun bir bileendir.
Cilt kuruluunu hafifletir: Hücresel yenilenmeyi tevik eder, kuruluu önler ve Allantoin hassas cildi daha esnek olmaya tevik eder.
Koruma: Cildi gerçekten yumuatan bir bileendir, çatlam, günete hasar görmü cildi korur, yaplan çalmalar UV kaynakl hücre hasarna kar koruduunu göstermitir.
Yattrc: Mükemmel bir yattrc olarak kabul edilir. Bu yüzden bebek ürünlerinde bile ciltleri tahri olmamas için kullanlr.
Yalanma kart – Antioksidan etki: Allantoinin topikal uygulamas ile ciltte serbest radikal aktivitenin azaltlmasna yardmc olur.