BENZOPHENONE 1
Synonyms
Benzophenone-1; Benzophenone 1; benzofenon 1; benzo fenon 1; benzofenone 1; benzofenon1; benzo phenone 1; benzophenone; benzophenon; benzophenon 1; benzofenon 1; benzofenon bir; benzo fenon bir; benzo fenon 1; benzofenon-1; aduvex 12; CAS Number: 131-56-6; advastab 48; benzophenone, 2,4-dihydroxy-; 4- benzoyl resorcinol; 4- benzoylresorcinol; dastib 263; 2,4- dihydroxy benzophenone; 2,4- dihydroxy-benzophenone; (2,4- dihydroxy-phenyl)-phenyl-methanone; 2,4- dihydroxybenzophenone; 2,4- dihydroxyphenyl phenyl ketone; (2,4- dihydroxyphenyl)(phenyl)methanone; (2,4- dihydroxyphenyl)phenylmethanone; eastman Inhibitor DHPB; inhibitor DHBP; methanone, (2,4-dihydroxyphenyl)phenyl-; quinsorb 010; seesorb 100; sumisorb 100; syntase 100; ultrafast 800; uvinol 400; uvinul 400; uvistat 12; viosorb 100; Benzophenone-1; Benzophenone 1; benzofenon 1; benzo fenon 1; benzofenone 1; benzofenon1; benzo phenone 1; benzophenone; benzophenon; benzophenon 1; benzofenon 1; benzofenon bir; benzo fenon bir; benzo fenon 1; benzofenon-1; aduvex 12; CAS Number: 131-56-6; advastab 48; benzophenone, 2,4-dihydroxy-; 4- benzoyl resorcinol; 4- benzoylresorcinol; dastib 263; 2,4- dihydroxy benzophenone; 2,4- dihydroxy-benzophenone; (2,4- dihydroxy-phenyl)-phenyl-methanone; 2,4- dihydroxybenzophenone; 2,4- dihydroxyphenyl phenyl ketone; (2,4- dihydroxyphenyl)(phenyl)methanone; (2,4- dihydroxyphenyl)phenylmethanone; eastman Inhibitor DHPB; inhibitor DHBP; methanone, (2,4-dihydroxyphenyl)phenyl-; quinsorb 010; seesorb 100; sumisorb 100; syntase 100; ultrafast 800; uvinol 400; uvinul 400; uvistat 12; viosorb 100; Benzophenone-1; Benzophenone 1; benzofenon 1; benzo fenon 1; benzofenone 1; benzofenon1; benzo phenone 1; benzophenone; benzophenon; benzophenon 1; benzofenon 1; benzofenon bir; benzo fenon bir; benzo fenon 1; benzofenon-1; aduvex 12; CAS Number: 131-56-6; advastab 48; benzophenone, 2,4-dihydroxy-; 4- benzoyl resorcinol; 4- benzoylresorcinol; dastib 263; 2,4- dihydroxy benzophenone; 2,4- dihydroxy-benzophenone; (2,4- dihydroxy-phenyl)-phenyl-methanone; 2,4- dihydroxybenzophenone; 2,4- dihydroxyphenyl phenyl ketone; (2,4- dihydroxyphenyl)(phenyl)methanone; (2,4- dihydroxyphenyl)phenylmethanone; eastman Inhibitor DHPB; inhibitor DHBP; methanone, (2,4-dihydroxyphenyl)phenyl-; quinsorb 010; seesorb 100; sumisorb 100; syntase 100; ultrafast 800; uvinol 400; uvinul 400; uvistat 12; viosorb 100; Benzophenone-1; Benzophenone 1; benzofenon 1; benzo fenon 1; benzofenone 1; benzofenon1; benzo phenone 1; benzophenone; benzophenon; benzophenon 1; benzofenon 1; benzofenon bir; benzo fenon bir; benzo fenon 1; benzofenon-1; aduvex 12; CAS Number: 131-56-6; advastab 48; benzophenone, 2,4-dihydroxy-; 4- benzoyl resorcinol; 4- benzoylresorcinol; dastib 263; 2,4- dihydroxy benzophenone; 2,4- dihydroxy-benzophenone; (2,4- dihydroxy-phenyl)-phenyl-methanone; 2,4- dihydroxybenzophenone; 2,4- dihydroxyphenyl phenyl ketone; (2,4- dihydroxyphenyl)(phenyl)methanone; (2,4- dihydroxyphenyl)phenylmethanone; eastman Inhibitor DHPB; inhibitor DHBP; methanone, (2,4-dihydroxyphenyl)phenyl-; quinsorb 010; seesorb 100; sumisorb 100; syntase 100; ultrafast 800; uvinol 400; uvinul 400; uvistat 12; viosorb 100
Benzophenone 1 CAS Number: 131-56-6
Picture of molecule3D/inchi
ECHA EINECS – REACH Pre-Reg: 205-029-4
FDA UNII: LJ54R4Z029
Nikkaji Web: J5.561A
Beilstein Number: 1311566
Benzophenone 1 MDL: MFCD00002277
Benzophenone 1 XlogP3: 3.20 (est)
Benzophenone 1 Molecular Weight: 214.22030000
Benzophenone 1 Formula: C13 H10 O3
Benzophenone-1 and nonylphenol stimulated MCF-7 breast cancer growth by regulating cell cycle and metastasis-related genes via an estrogen receptor α-dependent pathway.
PubMed:
What Is Benzophenone 1 ?
Benzophenone-1, -3, -4, -5, -9 and-11 are compounds made from 2-hydroxybenzophenone. These compounds are powders. In cosmetics and personal care products, Benzophenone-1 and Benzophenone-3 are used mostly in the formulation of nail polishes and enamels. These Benzophenone ingredients are also used in bath products, makeup products, hair products, sunscreens and skin care products.
Why is it used in cosmetics and personal care products?
Benzophenone-1, Benzophenone-3, Benzophenone-4, Benzophenone-5, Benzophenone-9 and Benzophenone-11 protect cosmetics and personal care products from deterioration by absorbing, reflecting, or scattering UV rays. When used as sunscreen ingredients, Benzophenone-3 and Benzophenone-4 protect the skin from UV rays.
Scientific Facts:
Benzophenone ingredients absorb and dissipate UV radiation, which serves to protect cosmetics and personal care products. As part of sunscreen products, which are OTC drugs in the United States, Benzophenone-3 (Oxybenzone) and Benzophenone-4 (Sulisobenzone) protect the skin from the harmful effects of the sun.
Exposing unprotected skin to UV light (primarily in the UV-B range) can result in sunburn and can promote premature aging of the skin and skin cancer.
BENZOPHENONE-1
BENZOPHENONE-1 is classified as :
Uv absorber
CAS Number 131-56-6
EINECS/ELINCS No: 205-029-4
COSING REF No: 32137
Chem/IUPAC Name: 2,4-Dihydroxybenzophenone
Benzophenone 1 can be used as a photo initiator in UV-curing applications[4] such as inks, imaging, and clear coatings in the printing industry. Benzophenone prevents ultraviolet (UV) light from damaging scents and colors in products such as perfumes and soaps.
Benzophenone 1 can also be added to plastic packaging as a UV blocker to prevent photo-degradation of the packaging polymers or its contents. Its use allows manufacturers to package the product in clear glass or plastic (such as a PETE water bottle).[5] Without it, opaque or dark packaging would be required.
In biological applications, benzophenones have been used extensively as photophysical probes to identify and map peptide-protein interactions.[6]
Benzophenone 1 is used as an additive in flavorings or perfumes for “sweet-woody-geranium-like notes.”[7]
Synthesis
Benzophenone 1 is produced by the copper-catalyzed oxidation of diphenylmethane with air.[8]
A laboratory route involves the reaction of benzene with carbon tetrachloride followed by hydrolysis of the resulting diphenyldichloromethane.[9] It can also be prepared by Friedel-Crafts acylation of benzene with benzoyl chloride in the presence of a Lewis acid (e.g. aluminium chloride) catalyst.
Another route of synthesis is through a palladium(II)/oxometalate catalyst. This converts an alcohol to a ketone with two groups on each side.[10]
Another, less well-known reaction to produce benzophenone is the pyrolysis of anhydrous calcium benzoate.[11]
Organic chemistry
Benzophenone 1 radical anion
Main article: Air-free technique
File:Making benzophenone radical anion.webm
Addition of a solution of benzophenone in THF to a vial containing THF, sodium metal, and a stir bar, yielding the deep blue benzophenone anion radical. Playback speed 4x original recording.
Alkali metals reduce benzophenone to the deeply blue colored radical anion, diphenylketyl:[12]
M + Ph2CO → M+Ph2CO•-
Generally sodium is used as the alkali metal. Although inferior in terms of safety and effectiveness relative to molecular sieves,[13] this ketyl is used in the purification of organic solvents, particularly ethers, because it reacts with water and oxygen to give non-volatile products.[14][15] The ketyl is soluble in the organic solvent being dried, so it accelerates the reaction of the sodium with water and oxygen. In comparison, sodium is insoluble, and its heterogeneous reaction is much slower. When excess alkali metal is present a second reduction may occur, resulting in a color transformation from deep blue to purple:[12]
M + M+Ph2CO•- → (M+)2(Ph2CO)2-
A solvent pot containing dibutyl ether solution of sodium benzophenone ketyl, which gives it its purple color.
Commercially significant derivatives and analogues
There are over 300 natural benzophenones, with great structural diversity and biological activities. They are being investigated as potential sources of new drugs. [16] Substituted benzophenones such as oxybenzone and dioxybenzone are used in many sunscreens. The use of benzophenone-derivatives which structurally resemble a strong photosensitizer has been criticized (see sunscreen controversy).
Michler’s ketone has dimethylamino substituents at each para position. The high-strength polymer PEEK is prepared from derivatives of benzophenone.
Benzophenone-1 is different than a similarly named substance that is considered to be toxic when absorbed or ingested. That substance is called Benzophenone. Unfortunately, the name Benzophenone-1 is often mistaken for Benzophenone, but they are actually two different chemical substances.
191476532466
CAS No.:
131-56-6
Synonyms: mgc4316 | 2,4-dhbp | bp-1 | uv-0 | uv12 | hhb | uv 12 | uf1 | synsorb | uf 1
Formula:
C13H10O3
Molecular Weight:
214.22
EINECS:
205-029-4
Safety
It is considered as “essentially nontoxic.”[8] Benzophenone is however banned as a food additive by the US Food and Drug Administration, despite the FDA’s continuing stance that this chemical does not pose a risk to public health under the conditions of its intended use.[17][18] Benzophenone derivatives are known to be pharmacologically active. From a molecular chemistry point of view interaction of benzophenone with B-DNA has been demonstrated experimentally.[19] The interaction with DNA and the successive photo-induced energy transfer is at the base of the benzophenone activity as a DNA photosensitizers and may explain part of its therapeutic potentialities.
In 2014, benzophenones were named Contact Allergen of the Year by the American Contact Dermatitis Society.[20]
Benzophenone 1 is an endocrine disruptor capable of binding to the pregnane X receptor.[21]
Benzophenone -1. Why we don’t use it. Among other things…
Long gone are the days of bottled car paint so ladies could match their nails to the duco… (and long gone are the days of Benzophenone -1)
It’s impossible to be 100% chemical-free and 100% organic when developing nail polish. In fact, no matter how hard we try, it just isn’t possible… yet! But we do believe in being as healthy and safe as possible.
Benzophenone -1
This one is the source of much controversy. Many 7-free, 10-free and ‘non-toxic’ nail polish brands still use Benzophenone-1 in their formulas. Benzophenone -1 is a UV blocker that is used in sunscreens as well as cosmetics to stop discolouration of products. Just to be clear, there are some studies that show it is relatively harmless in small quantities, however it has also been linked to breast cancer9, ovarian cancer10, prostate cancer11, and has been found in human placental tissue12. We have never used Benzophenone-1 and never will. Even though exposure in small quantities may be deemed harmless, the research speaks for itself.
Benzophenone 1 Cosmetics ingredient benzophenone is harmful to humans at current levels of exposure, according to a draft screening assessment by the Canadian government.
Benzophenone 1 If confirmed, the finding would see the substance listed on the toxic substances list (Schedule 1) of the Canadian Environmental Protection Act (Cepa) and open the door to regulatory risk management measures. The assessment covers risk to human health – or all populations except workers – and the environment.
Benzophenone 1, also known as diphenylmethanone, occurs naturally in some plants, but is synthesised for commercial use.
The substance is used in a range of products available to consumers, in which it performs several different roles, primarily related to its ability to absorb UV radiation. In some inks, toners and colourants, it reacts to light by initiating chemical reactions in the curing process. It is added to some types of plastic packaging to prevent UV-catalysed degradation.
Benzophenone 1 is also used in:
cosmetics;
paints;
coatings;
adhesives;
sealants; and
pest control products Benzophenone 1 .
The assessment identifies carcinogenicity and kidney toxicity as the critical effects for risk calculations. And consumer use of nail polish or paint containing the substance as the critical exposure scenarios.
It concludes that benzophenone 1 meets the criteria under paragraph 64(c) of Cepa, which relates to danger to human health. But does not meet the criteria under paragraphs 64(a) or 64(b), which relate to danger to the environment.
The government has published an accompanying “risk management scope” document, outlining proposed risk management options.
A 60-day public consultation period on the documents ends on 3 October.
In the EU
Benzophenone 1 has no mandatory classifications under EU CLP currently, but Denmark intends to propose category 2 carcinogenicity by December.
EU member Benzophenone 1 states originally scheduled REACH evaluation of the substance for 2013, based on concerns about possible carcinogenicity and wide dispersive use. But the evaluation conclusion did not become available until April this year.
Denmark, which undertook the work, found additional concern about possible endocrine disruption. However, in conclusion, it says that the substance meets the criteria for classification as category 2 carcinogenic, but is not a priority for further action with respect to endocrine disruption.
Benzophenone 1 UV filters are among substances or substance groups prioritised under the EU’s landmark human biomonitoring project, HBM4EU. The filters are one of nine entries on the second priority list, finalised last month.
CAS Numaras: 131-56-6
Resim molekülü3D / inchi
ECHA EINECS – REACH Ön Kayt: 205-029-4
FDA UNII: LJ54R4Z029
Nikkaji Web: J5.561A
Beilstein Numaras: 1311566
MDL: MFCD00002277
XlogP3: 3.20 (tahmin)
Moleküler Arlk: 214.22030000
Formül: C13 H10O3
Benzofenon-1 ve nonilfenol, östrojen reseptörüne bal bir yol yoluyla hücre döngüsünü ve metastazla ilgili genleri düzenleyerek MCF-7 meme kanseri büyümesini uyarmtr.
PubMed:
Bu ne?
Benzofenon-l, -3, -4, -5, -9 ve -11, 2-hidroksibenzofenondan yaplan bileiklerdir. Bu bileikler tozlardr. Kozmetik ve kiisel bakm ürünlerinde, Benzofenon-1 ve Benzofenon-3 çounlukla trnak cilalar ve emayelerin formülasyonunda kullanlr. Bu Benzophenone bileenleri banyo ürünlerinde, makyaj ürünlerinde, saç ürünlerinde, güne kremlerinde ve cilt bakm ürünlerinde de kullanlr.
Kozmetik ve kiisel bakm ürünlerinde neden kullanlr?
Benzofenon-1, Benzofenon-3, Benzofenon-4, Benzofenon-5, Benzofenon-9 ve Benzofenon-11 kozmetik ve kiisel bakm ürünlerini UV nlarn emerek, yanstarak veya saçarak bozulmaya kar korur. Güne koruyucu maddeler olarak kullanldnda, Benzofenon-3 ve Benzofenon-4 cildi UV nlarndan korur.
Bilimsel gerçekler:
Benzofenon bileenleri kozmetik ve kiisel bakm ürünlerini korumaya hizmet eden UV radyasyonunu emer ve datr. Amerika Birleik Devletleri’nde OTC ilaçlar olan güne koruyucu ürünlerin bir parças olarak, Benzophenone-3 (Oxybenzone) ve Benzophenone-4 (Sulisobenzone) cildi günein zararl etkilerinden korur.
Korunmayan cildi UV na maruz brakmak (özellikle UV-B aralnda) güne yanna neden olabilir ve cilt ve cilt kanserinin erken yalanmasn tevik edebilir.
Benzofenon-1
BENZOFENON-1 u ekilde snflandrlmtr:
UV emici
CAS Numaras 131-56-6
EINECS / ELINCS No: 205-029-4
COSING REF No: 32137
Chem / IUPAC Ad: 2,4-Dihidroksibenzofenon
Benzofenon 1, bask endüstrisinde mürekkepler, görüntüleme ve saydam kaplamalar gibi UV ile sertletirme uygulamalarnda [4] fotoraf balatc olarak kullanlabilir. Benzofenon, ultraviyole (UV) n parfüm ve sabun gibi ürünlerde kokulara ve renklere zarar vermesini önler.
Benzofenon 1 ayrca ambalaj polimerlerinin veya içeriinin foto-bozunmasn önlemek için UV engelleyici olarak plastik ambalaja eklenebilir. Kullanm üreticilerin ürünü effaf cam veya plastik (PETE su iesi gibi) içinde paketlemelerine izin verir. [5] Onsuz, opak veya karanlk ambalaj gerekli olacaktr.
Biyolojik uygulamalarda, benzofenonlar, peptit-protein etkileimlerini tanmlamak ve haritalamak için fotofiziksel sondalar olarak yaygn olarak kullanlmtr. [6]
Benzofenon 1 tatlandrclarda veya parfümlerde “tatl-odunsu-sardunya benzeri notalar” için bir katk maddesi olarak kullanlr. [7]
sentez
Benzofenon 1, difenilmetann hava ile bakr katalizli oksidasyonu ile üretilir. [8]
Bir laboratuar yolu, benzenin karbon tetraklorür ile reaksiyonunu ve ardndan elde edilen difenildiklorometann hidrolizini içerir. [9] Ayrca Lewis asidi (örn. Alüminyum klorür) katalizörü varlnda benzelin benzoil klorür ile asillenmesi ile hazrlanabilir.
Baka bir sentez yolu, bir paladyum (II) / oksometalat katalizörüdür. Bu, her iki tarafnda iki grup bulunan bir alkolü ketona dönütürür. [10]
Benzofenon üretmek için daha az bilinen bir baka reaksiyon, susuz kalsiyum benzoatn pirolizidir. [11]
Organik Kimya
Benzofenon 1 radikal anyonu
Ana madde: Havasz teknik
Dosya: Benzofenon radikal anyon.webm yapma
THF içindeki bir benzofenon çözeltisinin, koyu mavi benzofenon anyon radikalini veren THF, sodyum metal ve bir kartrma çubuuna sahip bir ieye eklenmesi. Oynatma hz 4x orijinal kayt.
Alkali metaller, benzofenonu koyu mavi renkli radikal anyon olan difenilketil’e düürür: [12]
M + Ph2CO → M + Ph2CO • –
Genellikle sodyum alkali metal olarak kullanlr. Moleküler eleklere göre güvenlik ve etkililik açsndan daha düük olmasna ramen, [13] bu ketil, organik çözücülerin, özellikle eterlerin saflatrlmasnda kullanlr, çünkü uçucu olmayan ürünler vermek için su ve oksijen ile reaksiyona girer. [14] [15] Ketil, kurutulan organik çözücü içinde çözünür, bu nedenle sodyumun su ve oksijen ile reaksiyonunu hzlandrr. Buna karlk, sodyum çözünmez ve heterojen reaksiyonu çok daha yavatr. Fazla alkali metal bulunduunda ikinci bir azalma meydana gelebilir ve bu da derin maviden mora renk dönüümü ile sonuçlanr: [12]
M + M + Ph2CO • – → (M +) 2 (Ph2CO) 2-
Sodyum benzofenon ketilin dibutil eter çözeltisini içeren ve mor rengini veren bir çözücü kab.
Ticari olarak önemli türevler ve analoglar
Büyük yapsal çeitlilik ve biyolojik aktiviteler ile 300’den fazla doal benzofenon vardr. Potansiyel yeni ilaç kaynaklar olarak aratrlmaktadr. [16] Oksibenzon ve dioksibenzon gibi ikame edilmi benzofenonlar birçok güne kreminde kullanlmaktadr. Yapsal olarak güçlü bir a duyarllatrcya benzeyen benzofenon türevlerinin kullanm eletirilmitir (bkz. Güne koruyucu tartmas)
Michler’n ketonunun her bir para pozisyonunda dimetilamino ikameleri vardr. Yüksek mukavemetli polimer PEEK, benzofenon türevlerinden hazrlanr.
Benzofenon-1, emildiinde veya yutulduunda toksik olduu düünülen benzer bir maddeden farkldr. Bu maddeye Benzofenon denir. Ne yazk ki, Benzofenon-1 ad genellikle Benzofenon ile kartrlr, ancak aslnda iki farkl kimyasal maddedir.
191476532466
CAS Numaras.:
131-56-6
E anlamllar: mgc4316 | 2,4-dhbp | bp-1 | uv-0 | uv12 | hhb | uv 12 | uf1 | synsorb | uf 1
Formül:
C13H10O3
Moleküler arlk:
214,22
EINECS:
205-029-4
Emniyet
“Esasen toksik olmayan” olarak kabul edilir. [8] Benzofenon, FDA’nn bu kimyasaln amaçlanan koullar altnda halk sal için bir risk oluturmad yönündeki tutumuna ramen ABD Gda ve laç daresi tarafndan bir gda katk maddesi olarak yasaklanmtr. kullanm. [17] [18] Benzofenon türevlerinin farmakolojik olarak aktif olduu bilinmektedir. Moleküler kimya açsndan, benzofenonun B-DNA ile etkileimi deneysel olarak gösterilmitir. [19] DNA ile etkileim ve ardk foto-indüklenmi enerji transferi, bir DNA a duyarllatrc olarak benzofenon aktivitesinin temelindedir ve terapötik potansiyelinin bir ksmn açklayabilir.
2014 ylnda, benzofenonlar Amerikan Kontakt Dermatit Dernei tarafndan Yln Temas Alerjeni seçildi. [20]
Benzofenon 1, pregnan X reseptörüne balanabilen bir endokrin ykcdr. [21]
Benzofenon -1. Neden kullanmyoruz. Dier eylerin yan sra…
Uzun zamandr ielenmi araba boyas günleri var, böylece bayanlar trnaklarn duco ile eletirebilirler… (ve uzun zamandr Benzophenone -1 günleri)
Trnak cilas gelitirirken% 100 kimyasal içermeyen ve% 100 organik olmak imkanszdr. Aslnda, ne kadar urarsak çalalm, bu henüz mümkün deil… henüz! Ancak mümkün olduunca salkl ve güvenli olduuna inanyoruz.
Benzofenon -1
Bu, çok tartmann kaynadr. Birçok 7, 10 ve ‘toksik olmayan’ oje markas hala formüllerinde Benzophenone-1 kullanmaktadr. Benzofenon -1, güne kremlerinde ve kozmetiklerde ürünlerin renk deitirmesini durdurmak için kullanlan bir UV engelleyicidir. Açkça söylemek gerekirse, küçük miktarlarda nispeten zararsz olduunu gösteren baz çalmalar vardr, ancak ayn zamanda meme kanseri9, yumurtalk kanseri10, prostat kanseri11 ile balantldr ve insan plasental dokusunda bulunmutur12. Ben hiç Benzofenon-1 kullanmadk ve asla kullanamayacaz. Küçük miktarlarda maruziyet zararsz saylsa da, aratrma kendisi için konuur.
Benzofenon 1 Kanada hükümeti tarafndan yaplan taslak tarama deerlendirmesine göre kozmetik bileen benzofenon, mevcut maruziyet seviyelerinde insanlar için zararldr.
Benzofenon 1 Dorulanrsa, bulgu Kanada Çevre Koruma Yasas’nn (Cepa) toksik maddeler listesinde (Çizelge 1) listelenen maddeyi görecek ve düzenleyici risk yönetimi önlemlerinin kapsn açacaktr. Deerlendirme, insan sal ya da içiler dndaki tüm nüfus ve çevre için riski kapsamaktadr.
Difenilmetanon olarak da bilinen benzofenon 1, baz bitkilerde doal olarak bulunur, ancak ticari kullanm için sentezlenir.
Bu madde, tüketiciler için mevcut olan ve öncelikle UV radyasyonunu emme yetenei ile ilgili birkaç farkl rol oynad bir dizi üründe kullanlmaktadr. Baz mürekkeplerde, tonerlerde ve renklendiricilerde kürleme ileminde kimyasal reaksiyonlar balatarak a tepki verir. UV katalizli bozunmay önlemek için baz plastik ambalaj tiplerine eklenir.
Benzofenon 1 ayrca u ekilde kullanlr:
makyaj malzemeleri;
boyalar;
kaplamalar;
yaptrclar;
szdrmazlk; ve
haere kontrol ürünleri Benzofenon 1.
Deerlendirme, kanserojenlii ve böbrek toksisitesini risk hesaplamalar için kritik etkiler olarak tanmlar. Kritik maruziyet senaryolar olarak, maddeyi içeren oje veya boya tüketici kullanm.
Benzofenon 1’in, Cepa’nn insan sal için tehlike ile ilgili 64 (c) paragrafndaki kriterleri karlad sonucuna varr. Ancak çevre için tehlike ile ilgili olan 64 (a) veya 64 (b) paragraflar altndaki kriterleri karlamamaktadr.
Hükümet, önerilen risk yönetimi seçeneklerini ana hatlaryla açklayan bir “risk yönetimi kapsam” belgesi yaynlamtr.
Belgelerle ilgili 60 günlük bir halkn katlm süreci 3 Ekim’de sona eriyor.
AB’de
Benzofenon 1’in u anda AB CLP kapsamnda zorunlu snflandrmalar yoktur, ancak Danimarka Aralk’a kadar kategori 2 kanserojenlik önermeyi planlamaktadr.
AB üyesi Benzofenon 1, olas kanserojenlik ve yaygn datc kullanm hakkndaki endielere dayanarak, balangçta maddenin 2013 için REACH deerlendirmesini planladn belirtmektedir. Ancak deerlendirme sonucu bu yl nisan ayna kadar mevcut deildi.
Çalmay üstlenen Danimarka, olas endokrin bozulmas hakknda ek endie buldu. Bununla birlikte, sonuç olarak, maddenin kategori 2 kanserojen olarak snflandrma kriterlerini karladn, ancak daha sonraki eylemler için bir öncelik olmadn söylüyor.
endokrin bozulmasna sayg.
Benzofenon 1 UV filtreleri, AB’nin dönüm noktas olan insan biyo-izleme projesi HBM4EU kapsamnda önceliklendirilen maddeler veya madde gruplar arasndadr. Filtreler, ikinci öncelik listesindeki geçen ay tamamlanan dokuz giriten biridir.