BENZYL BENZOATE (BENZL BENZOAT)

BENZYL BENZOATE

SYNONYMS: Benzyl Benzoate; benzyl benzoate; benzylbenzoate; benzyl benzoat; benzil benzoat; benzilbenzoat; banzil benzoat; banzilbenzoat; bensil bensoat; bensilbensoat; benzylbenzoat; bensil benzoat; bensilbenzoat; Benzylbenzoate; Benzyl Benzoat; Benzil Benzoat; Benzilbenzoat; Bensil Bensoat; Bensilbensoat; Benzylbenzoat; Bensil Benzoat; Bensilbenzoat; BENZYL BENZOATE; BENZYLBENZOATE; BENZYL BENZOAT; BENSLBENZOAT; BENSL BENZOAT; BENSL BENSOAT; BENSLBENSOAT; Acaril; Acarosan; Ansar; Antiscabiosum; Ascabiol; Benzanil; Benzemul; benzyl benzoate; Benzylbenzoaat Smeersel FNA; Novoscabin; BENZYL BENZOATE; 120-51-4; Ascabiol; Benylate; Novoscabin; Benzoic acid, phenylmethyl ester; Scabitox; Scobenol; Ascabin; Benzyl phenylformate; Benzoic acid, benzyl ester; Phenylmethyl benzoate; Benzoic acid benzyl ester; Benzylets; Colebenz; Peruscabin; Scabagen; Scabanca; Scabiozon; Vanzoate; Scabide; Benzyl benzenecarboxylate; benzylbenzoate; Antiscabiosum; Benzylis benzoas; Benzyl alcohol benzoic ester; Peruscabina; Spasmodin; Venzonate; Benzylum benzoicum; Benzylester kyseliny benzoove; Benzoesaeurebenzylester; Caswell No. 082; Benzylbenzenecarboxylate; Venzoate; FEMA Number 2138; Benzyl benzoate (natural); NSC 8081; UNII-N863NB338G; FEMA No. 2138HSDB 208; BENZOIC ACID PHENYLMETHYLESTER; EINECS 204-402-9; Benzylester kyseliny benzoove [Czech]; EPA Pesticide Chemical Code 009501; BRN 2049280; CHEMBL1239; AI3-00523; CHEBI:41237; SESFRYSPDFLNCH-UHFFFAOYSA-N; MFCD00003075; SBB058609; NCGC00094981-03; DSSTox_CID_9153; DSSTox_RID_78686; DSSTox_GSID_29153; Q-200696; Benzyl benzoate, analytical standard; Benzoate de benzyle; BZM; CAS-120-51-4; SMR000471875; benzylbenzoat; Benzyl benzoate [USP:JAN]; Acarobenzyl; Benzevan; Benzyl benzoate [USAN:JAN]; Benzyl benzoat; Benzoic acid phenylmethyl ester; Benzyl ester; 1dzm; Benylate (TN); benzoic acid benzyl; Benzoesaurebenzylester; Spectrum_001240; Spectrum2_000532; Spectrum3_001757; Spectrum4_000773; Spectrum5_001128; Benzyl benzoate 99+ %; ACMC-1C8AP; WLN: RVO1R; D0G1VX; Benzyl benzoate, >=99%; AC1L1DH0; SCHEMBL3038; BENZYL BENZOATE BP98; BSPBio_003494; KBioGR_001186; KBioSS_001720; 4-09-00-00307 (Beilstein Handbook Reference); KSC174Q0R; MLS001066412; MLS001336003; MLS001336004; DivK1c_000204; SPECTRUM1503002; SPBio_000543; Benzyl benzoate (JP17/USP); AC1Q661C; ZINC1021; DTXSID8029153; BENZOIC ACID,BENZYL ESTER; Benzyl benzoate, 99% 250g; CTK0H4808; HMS500K06, KBio1_000204; KBio2_001720; KBio2_004288; KBio2_006856; KBio3_002714; KS-00000UHX; NSC8081; MolPort-001-740-297; NINDS_000204; HMS1921P16; HMS2092F20; HMS2269D24; N863NB338G; Pharmakon1600-01503002; HY-B0935; NSC-8081; Tox21_111372; Tox21_201337; Tox21_303418; ANW-17509; BDBM50134035; CCG-39578; NSC758204; s4599; AKOS003495939; Benzyl benzoate, >=99%, FCC, FG; Tox21_111372_1; CHM0028580; DB00676; FCH2703790; LS-2573; MCULE-4369643785; NSC-758204; RL00855; RTR-003391; IDI1_000204; Benzyl benzoate, for synthesis, 99.0%; NCGC00094981-01; NCGC00094981-02; NCGC00094981-04; NCGC00094981-05; NCGC00094981-07i NCGC00257502-01; NCGC00258889-01; AC-17033; AN-22825; CC-24472; KB-75431; OR011551; ZB000222; SBI-0051748.P002; Benzoic acid-benzyl ester (Benzyl benzoate); DB-041563; TR-003391; B0064; FT-0622708 ST50406335; Benzyl benzoate, natural, >=99%, FCC, FG; Benzyl benzoate, ReagentPlus(R), >=99.0%; Benzyl benzoate, SAJ first grade, >=98.0%; Benzyl benzoate, tested according to Ph.Eur.; A19449; Benzyl benzoate, SAJ special grade, >=99.0%; C12537; D01138; AB00052298_07; Benzyl benzoate, Vetec(TM) reagent grade, 98%; Benzyl benzoate, meets USP testing specifications; C-24290; SR-01000763773; I14-6951; SR-01000763773-2; Benzoic acid-benzyl ester 5000 ng/microl in n-Hexane; Benzoic acid benzyl ester; Benzoic acid phenylmethyl ester; Benzyl benzoate, certified reference material, TraceCERT(R); Benzyl benzoate, United States Pharmacopeia (USP) Reference Standard; Benzyl benzoate, Pharmaceutical Secondary Standard; Certified Reference Material; InChI=1/C14H12O2/c15-14(13-9-5-2-6-10-13)16-11-12-7-3-1-4-8-12/h1-10H,11H; Benzyl Benzoate; Acaril; Acarosan; Ansar; Antiscabiosum; Ascabiol; Benzanil; Benzemul; benzyl benzoate; Benzylbenzoaat Smeersel FNA; Novoscabin; BENZYL BENZOATE; 120-51-4; Ascabiol; Benylate; Novoscabin; Benzoic acid, phenylmethyl ester; Scabitox; Scobenol; Ascabin; Benzyl phenylformate; Benzoic acid, benzyl ester; Phenylmethyl benzoate; Benzoic acid benzyl ester; Benzylets; Colebenz; Peruscabin; Scabagen; Scabanca; Scabiozon; Vanzoate; Scabide; Benzyl benzenecarboxylate; benzylbenzoate; Antiscabiosum; Benzylis benzoas; Benzyl alcohol benzoic ester; Peruscabina; Spasmodin; Venzonate; Benzylum benzoicum; Benzylester kyseliny benzoove; Benzoesaeurebenzylester; Caswell No. 082; Benzylbenzenecarboxylate; Venzoate; FEMA Number 2138; Benzyl benzoate (natural); NSC 8081; UNII-N863NB338G; FEMA No. 2138HSDB 208; BENZOIC ACID PHENYLMETHYLESTER; EINECS 204-402-9; Benzylester kyseliny benzoove [Czech]; EPA Pesticide Chemical Code 009501; BRN 2049280; CHEMBL1239; AI3-00523; CHEBI:41237; SESFRYSPDFLNCH-UHFFFAOYSA-N; MFCD00003075; SBB058609; NCGC00094981-03; DSSTox_CID_9153; DSSTox_RID_78686; DSSTox_GSID_29153; Q-200696; Benzyl benzoate, analytical standard; Benzoate de benzyle; BZM; CAS-120-51-4; SMR000471875; benzylbenzoat; Benzyl benzoate [USP:JAN]; Acarobenzyl; Benzevan; Benzyl benzoate [USAN:JAN]; Benzyl benzoat; Benzoic acid phenylmethyl ester; Benzyl ester; 1dzm; Benylate (TN); benzoic acid benzyl; Benzoesaurebenzylester; Spectrum_001240; Spectrum2_000532; Spectrum3_001757; Spectrum4_000773; Spectrum5_001128; Benzyl benzoate 99+ %; ACMC-1C8AP; WLN: RVO1R; D0G1VX; Benzyl benzoate, >=99%; AC1L1DH0; SCHEMBL3038; BENZYL BENZOATE BP98; BSPBio_003494; KBioGR_001186; KBioSS_001720; 4-09-00-00307 (Beilstein Handbook Reference); KSC174Q0R; MLS001066412; MLS001336003; MLS001336004; DivK1c_000204; SPECTRUM1503002; SPBio_000543; Benzyl benzoate (JP17/USP); AC1Q661C; ZINC1021; DTXSID8029153; BENZOIC ACID,BENZYL ESTER; Benzyl benzoate, 99% 250g; CTK0H4808; HMS500K06, KBio1_000204; KBio2_001720; KBio2_004288; KBio2_006856; KBio3_002714; KS-00000UHX; NSC8081; MolPort-001-740-297; NINDS_000204; HMS1921P16; HMS2092F20; HMS2269D24; N863NB338G; Pharmakon1600-01503002; HY-B0935; NSC-8081; Tox21_111372; Tox21_201337; Tox21_303418; ANW-17509; BDBM50134035; CCG-39578; NSC758204; s4599; AKOS003495939; Benzyl benzoate, >=99%, FCC, FG; Tox21_111372_1; CHM0028580; DB00676; FCH2703790; LS-2573; MCULE-4369643785; NSC-758204; RL00855; RTR-003391; IDI1_000204; Benzyl benzoate, for synthesis, 99.0%; NCGC00094981-01; NCGC00094981-02; NCGC00094981-04; NCGC00094981-05; NCGC00094981-07i NCGC00257502-01; NCGC00258889-01; AC-17033; AN-22825; CC-24472; KB-75431; OR011551; ZB000222; SBI-0051748.P002; Benzoic acid-benzyl ester (Benzyl benzoate); DB-041563; TR-003391; B0064; FT-0622708 ST50406335; Benzyl benzoate, natural, >=99%, FCC, FG; Benzyl benzoate, ReagentPlus(R), >=99.0%; Benzyl benzoate, SAJ first grade, >=98.0%; Benzyl benzoate, tested according to Ph.Eur.; A19449; Benzyl benzoate, SAJ special grade, >=99.0%; C12537; D01138; AB00052298_07; Benzyl benzoate, Vetec(TM) reagent grade, 98%; Benzyl benzoate, meets USP testing specifications; C-24290; SR-01000763773; I14-6951; SR-01000763773-2; Benzoic acid-benzyl ester 5000 ng/microl in n-Hexane; Benzoic acid benzyl ester; Benzoic acid phenylmethyl ester; Benzyl benzoate, certified reference material, TraceCERT(R); Benzyl benzoate, United States Pharmacopeia (USP) Reference Standard; Benzyl benzoate, Pharmaceutical Secondary Standard; Certified Reference Material; InChI=1/C14H12O2/c15-14(13-9-5-2-6-10-13)16-11-12-7-3-1-4-8-12/h1-10H,11H; 120-51-4 [RN]; 204-402-9 [EINECS]; Benzoate de benzyle [French] [ACD/IUPAC Name]; benzoic acid benzyl ester; benzoic acid, benzyl ester; Benzoic acid, phenylmethyl ester [ACD/Index Name]; Benzyl benzoate [ACD/IUPAC Name] [Wiki]; Benzylbenzoat [German]; Benzyl-benzoat [German] [ACD/IUPAC Name]; N863NB338G; phenylmethyl benzoate; [120-51-4]; 2049280 [Beilstein]; 347840-01-1 [RN]; 352431-26-6 [RN]; 4-09-00-00307; (Beilstein Handbook Reference) [Beilstein]; 613-62-7 [RN]; Acarilbial; Acarilbial (Trade name); Acaril-S; Acaril-S (Trade name); Acaril-S; Acarilbial; Acarsan; Acil; Antiscabiosum; Antiscabiosum für Kinder; Ascabiol; Ascalol; B.B. Lotion; BE BO; Benzalcor; Benzilbenzoat; Benzogal; Benzotal; Bezo; Finsarna; Gensarna; Miticocan; Novoscabin; Opele; Pharcobenzyl; Sanasar; Saniscabis; Scabicon; Scabiex; Scabin; Scabisol; Scabitox; Tekoce; Zilaben; Acarobenzyl; Acarobenzyl; Benylate; Benzevan; Benzoate de benzyle; Benzoes??urebenzylester; Benzoic acid phenylmethylester; Benzoic acid, benzyl ester; Benzoic acid, phenylmethyl ester; Benzyl benzoat; Benzylis benzoas; Phenylmethyl benzoate; Acarobenzyl; Benzevan; Benzoate de benzyle; Benzoesäurebenzylester; Benzyl benzoat; Benzylis benzoas; Phenylmethyl benzoate; Spasmodine; Acarsan; Acarsan (Trade name) Acil; Acil (Trade name); Antiscabiosum; Antiscabiosum (Trade name); Antiscabiosum für Kinder; Antiscabiosum für Kinder (Trade name); Ascabin; Ascabiol; Ascabiol (Trade name); Ascalol, Ascalol (Trade name); B.B. Lotion; B.B. Lotion (Trade name)BE BO; BE BO (Trade name); Benylate [Trade name]; Benylate (TN); Benzalcor; Benzalcor (Trade name); Benzevan; Benzilbenzoat; Benzilbenzoat (Trade name); Benzoate de benzyle [ACD/IUPAC Name]; Benzoesaeurebenzylester; Benzoesäurebenzylester; Benzogal; Benzogal (Trade name); benzoic acid phenylmethyl ester; BENZOIC ACID; PHENYLMETHYLESTER; BENZOIC ACID,BENZYL ESTER; Benzoic acid-benzyl ester (Benzyl benzoate); Benzoic acid-benzyl ester 100 ng/?l in Methanol; Benzoic acid-benzyl ester 100 ng/µl in Methanol; Benzoic acid-benzyl ester 5000 ng/?l in n-Hexane; Benzoic acid-benzyl ester 5000 ng/µl in n-Hexane; Benzotal; Benzotal (Trade name); Benzyl 2-naphthyl ether; Benzyl alcohol benzoic ester; Benzyl benzenecarboxylate; Benzyl benzoat; Benzyl benzoate (JP15/USP) [USP]; Benzyl benzoate (natural); Benzyl benzoate [USAN:JAN]; BENZYL BENZOATE BP98; Benzyl Benzoate-d12; Benzyl phenylformate; Benzylbenzenecarboxylate; benzylbenzoate; benzyl-benzoate; Benzyl-d5 Benzoate; Benzylester kyseliny benzoove; Benzylester kyseliny benzoove [Czech]; Benzylets; Benzylis benzoas; Benzylum benzoicum; Bezo; Bezo (Trade name); BSPBio_003494; BZM; CHEBI:41237; Colebenz; DG4200000; EINECS 204-402-9; Finsarna; Finsarna (Trade name); Gensarna; Gensarna (Trade name); IDI1_000204; InChI=1/C14H12O2/c15-14(13-9-5-2-6-10-13)16-11-12-7-3-1-4-8-12/h1-10H,11H; Mange Treatment; MFCD00003075 [MDL number]; Miticocan; Miticocan (Trade name); MLS001066412; NCGC00094981-01; NCGC00094981-02; NCGC00094981-03; Novoscabin; Novoscabin (Trade name); Opele; Opele (Trade name); Peruscabin; Peruscabina; Pharcobenzyl; Pharcobenzyl (Trade name); Pharmakon1600-01503002; Sanasar; Sanasar (Trade name); Saniscabis; Saniscabis (Trade name); Scabagen; Scabanca; Scabicon; Scabicon (Trade name); Scabide; Scabiex; Scabiex (Trade name); Scabin; Scabin (Trade name); Scabiozon; Scabisol; Scabisol (Trade name); Scabitox; Scabitox (Trade name); SCOBENOL; SMR000471875; Spasmodin; Spasmodine; SPECTRUM1503002; Spectrum5_001128; ST5406335; Tekoce; Tekoce (Trade name); UNII:N863NB338G; UNII-N863NB338G; Vanzoate; Venzoate; Venzonate; WLN: RVO1R; Zilaben; ???????? [Japanese]; BENZL BENZOAT; BENZIL BENZOAT; BENZL BENZOAT; BENZYL BENZOAT; BENZL BENZOT; BENZL BENZAT; BENZIL BENZIL; BEZIL BENZOAT; benzil benzoat; benzl benzoat; benzl benzoat; benzyl benzoat; benzyl ; benzoat; benzoate; benzyl benzoate; benzyl benzoat; benzil benzoat; benzl benzoat; SESFRYSPDFLNCH-UHFFFAOYSA-N; Benzoic acid benzyl ester; antiscabiosum : ascabin : ascabiol : benylate : benzoic acid benzyl ester : benzoic acid phenyl methyl ester : benzyl alcohol benzoic ester : benzyl benzene carboxylate : benzyl phenyl formate : benzylets : colebenz : novoscabin : peruscabin : phenyl methyl benzoate : phenylmethyl benzoate : scabanca : vanzoate : venzonate : Aceto : Benzyl Benzoate : Advanced Biotech : benzyl benzoate 99pc min. natural; Benzyl 3-bromopropyl ether; Zylate;Scabide;ASCABIN;Benylate;Colebenz;Scabagen;Scabanca;Scabitox;Scobenol;Vanzoate; BENZYL BENZOATE; 120-51-4; Ascabiol; Benylate; Novoscabin; Benzoic acid benzyl ester; Benzoic acid, phenylmethyl ester; Ascabin; Scabitox; Scobenol; Benzyl phenylformate; Phenylmethyl benzoate; Benzoic acid, benzyl ester; Benzylets; Colebenz; Peruscabin; Scabagen; Scabanca; Scabiozon; Vanzoate; Scabide; Benzyl benzenecarboxylate; benzylbenzoate; Antiscabiosum; Benzylis benzoas; Benzyl alcohol benzoic ester; Peruscabina; Spasmodin; Venzonate; Benzylum benzoicum; Benzylester kyseliny benzoove; Benzoesaeurebenzylester; BENZOIC ACID PHENYLMETHYLESTER; Caswell No. 082; Benzylbenzenecarboxylate; Venzoate; FEMA Number 2138; Benzyl benzoate (natural); NSC 8081; UNII-N863NB338G; FEMA No. 2138; HSDB 208; EINECS 204-402-9; MFCD00003075; Benzylester kyseliny benzoove [Czech]; EPA Pesticide Chemical Code 009501; BRN 2049280; CHEMBL1239; AI3-00523; CHEBI:41237; SESFRYSPDFLNCH-UHFFFAOYSA-N; N863NB338G; NCGC00094981-03; Benzyl benzoate, 99+%; DSSTox_CID_9153; DSSTox_RID_78686; DSSTox_GSID_29153; Benzyl benzoate, analytical standard; Benzoate de benzyle; BZM; CAS-120-51-4; SMR000471875benzylbenzoat; Benzyl benzoate [USP:JAN]; Acarobenzyl; Benzevan; benzyl-benzoate; Benzyl benzoate [USAN:JAN]; Benzyl benzoat; Benzoic acid phenylmethyl ester; Benzyl ester; 1dzm; Benylate (TN); Benzoesaurebenzylester; Spectrum_001240; Benzoic acid-benzyl ester; Spectrum2_000532; Spectrum3_001757; Spectrum4_000773; Spectrum5_001128; Benzyl benzoate 99+ %; ACMC-1C8AP; WLN: RVO1R; Benzyl benzoate, >=99%; EC 204-402-9; AC1L1DH0; SCHEMBL3038; BENZYL BENZOATE BP98; BSPBio_003494; KBioGR_001186; KBioSS_001720; 4-09-00-00307 (Beilstein Handbook Reference); KSC174Q0R; MLS001066412; MLS001336003; MLS001336004; DivK1c_000204; SPECTRUM1503002; SPBio_000543; Benzyl benzoate (JP17/USP); AC1Q661C; ZINC1021; DTXSID8029153; BENZOIC ACID,BENZYL ESTER; CTK0H4808; HMS500K06; KBio1_000204; KBio2_001720; KBio2_004288; KBio2_006856; KBio3_002714; KS-00000UHX; NSC8081; NINDS_000204; HMS1921P16; HMS2092F20; HMS2269D24; Pharmakon1600-01503002; HY-B0935; NSC-8081; Tox21_111372; Tox21_201337; Tox21_303418; ANW-17509; BDBM50134035; CCG-39578; NSC758204; s4599; SBB058609; STL183088; AKOS003495939; Benzyl benzoate, >=99%, FCC, FG; Tox21_111372_1; DB00676; LS-2573; MCULE-4369643785; NSC-758204; RL00855; RTR-003391; IDI1_000204; Benzyl benzoate, for synthesis, 99.0%; NCGC00094981-01; NCGC00094981-02; NCGC00094981-04; NCGC00094981-05; NCGC00094981-07; NCGC00257502-01; NCGC00258889-01; AC-17033; AK308304; AN-22825; ZB000222; SBI-0051748.P002; DB-041563; TR-003391; B0064; FT-0622708; ST50406335; Benzyl benzoate, natural, >=99%, FCC, FG; Benzyl benzoate, ReagentPlus(R), >=99.0%; Benzyl benzoate, SAJ first grade, >=98.0%; Benzyl benzoate, tested according to Ph.Eur.; A14577; A19449; Benzyl benzoate, SAJ special grade, >=99.0%; C12537; D01138; AB00052298_07; Benzyl benzoate, Vetec(TM) reagent grade, 98%; Benzyl benzoate, meets USP testing specifications; SR-01000763773; Benzoic acid-benzyl ester 5000 microg/mL in Hexane; I14-6951; Q-200696; SR-01000763773-2; BRD-K52072429-001-06-1; Benzoic acid benzyl ester; Benzoic acid phenylmethyl ester; Benzyl benzoate, certified reference material, TraceCERT(R); Benzyl benzoate, United States Pharmacopeia (USP) Reference Standard; Benzyl benzoate,benzyl alcohol;phenylmethanol;benzenemethanol;100-51-6;phenylcarbinol;benzylic alcohol;Phenyl Methanol;Caswell No. 081F;.alpha.-Toluenol;Benzyl alcohol (natural);Alcool benzilico [DCIT];Itch-X;C6H5CH2OH;CHEMBL720;D05OIS;BENZYL ALCOHOL, ACS;EC 202-859-9;AC1L18SY;MolPort-001-783-216;HMS3264B16;Pharmakon1600-01502555;ZINC895302;Benzyl alcohol, analytical standard;Benzyl alcohol, AR, >=99.5%;HY-B0892;NSC-8044;Benzyl alcohol, anhydrous, 99.8%;Tox21_111172;Tox21_202447;Tox21_300044;BBL011938;LS-307;MFCD00004599;NSC760098;s4600;SBB058558;STL163453;Benzyl alcohol, >=99%, FCC, FG;AKOS000119907;AS04466;Benzyl alcohol, natural, >=98%, FG;BENZYL ALCOHOL, U.S.P./N.F.;CCG-213843;DB06770;LS41488;MCULE-6011707909;NSC-760098;RP18893;RTR-033774;NCGC00091865-02;NCGC00091865-03;NCGC00091865-04;NCGC00254154-01;NCGC00259996-01;1336-27-2;AJ-24171;BC222892;Benzyl alcohol, ACS reagent, >=99.0%;Benzyl alcohol, ReagentPlus(R), >=99%;Benzyl alcohol, USP, 98.0-100.5%;I765;SC-47293;ZB015017;KB-200532;TR-033774;B2378;Benzyl alcohol, tested according to Ph.Eur.;E1519;FT-0622812;ST24048908;ST51028320;Benzyl alcohol, p.a., ACS reagent, 99.0%;Benzyl alcohol, SAJ first grade, >=98.5%;3983-EP2269992A1;3983-EP2270004A1;3983-EP2270005A1;3983-EP2270011A1;3983-EP2270505A1;3983-EP2272516A2

Pharmaceutical Secondary Standard; Certified Reference Material Drugs and Supplement Benzyl Benzoate (Topical Route)Print Description and Brand Names Before Using Proper Use Precautions Side Effects Products and services The Mayo Clinic Diet: What is your weight-loss goal? 5-10 lbs, 11-25 lbs, or 25+ lbs Free E-newsletter Subscribe to Housecall Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Sign up now Proper Use Benzyl benzoate usually comes with patient directions. Read them carefully before using this medicine. Use this medicine only as directed. Do not use more of it and do not use it more often than recommended on the label. To do so may increase the chance of absorption through the skin and the chance of side effects. Keep this medicine away from the eyes and other mucous membranes, such as the inside of the nose, because it may cause irritation . If you accidentally get some in your eyes, flush them thoroughly with water at once. Do not use benzyl benzoate on open wounds, such as cuts or sores on the skin or scalp. To do so may increase the amount of absorption, which may increase the chance of side effects. Your sexual partner or partners, especially, and all members of your household may need to be treated also, since the infestation may spread to persons in close contact. If these persons have not been examined for infestation or if you have any questions about this, check with your doctor. To use this medicine for lice: If your hair has any cream, lotion, ointment, or oil-based product on it, shampoo, rinse, and dry your hair and scalp well before applying benzyl benzoate. Apply enough medicine to thoroughly wet the dry hair and scalp or skin. Allow the medicine to remain on the affected areas for 24 hours. Then, thoroughly wash the affected areas with warm water and soap or regular shampoo. Rinse thoroughly and dry with a clean towel. After rinsing and drying, use a fine-toothed comb (less than 0.3 mm between the teeth) to remove any remaining nits (eggs) or nit shells from your hair, or, if you have fine hair, you may use a tweezer or your fingernails to pick nits out. To use this medicine for scabies: If your skin has any cream, lotion, ointment, or oil on it, wash, rinse, and dry your skin well before applying benzyl benzoate. If you take a bath or shower before using benzyl benzoate, dry the skin well before applying the medicine. Apply enough medicine to cover the entire skin surface from the neck down, including the soles of your feet, and rub in well. Allow the medicine to remain on the body for 24 hours. Then, thoroughly wash the body with warm water and soap. Rinse thoroughly and dry with a clean towel. Immediately after using benzyl benzoate, wash your hands to remove any medicine that may be on them. Treatment may need to be repeated for severe infestation. Dosing The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For topical dosage form (emulsion): For lice infestation: Adults-Use just one time. For severe cases, treatment may be repeated two or three times after twenty-four hours. Children- For infants: Use mixed with three parts of water, just one time. For older children: Use mixed with an equal quantity of water, just one time. For scabies infestation: Adults-Use just one time. For severe cases, treatment may be repeated after twenty-four hours one time anytime within five days. Children- For infants: Use mixed with three parts of water, just one time. For older children: Use mixed with an equal quantity of water, just one time. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Before Using Precautions Portions of this document last updated: Feb. 01, 2019 Copyright © 2019 IBM Watson Health. All rights reserved. Information is for End User’s use only and may not be sold, redistributed or otherwise used for commercial purposes. Benzyl benzoate From Wikipedia, the free encyclopedia Jump to navigationJump to search benzoate Benzyl benzoate structure.svg Benzyl benzoate ball-and-stick.png Clinical data Trade names Ascabin, Ascabiol, Ascarbin, Tenutex, others Synonyms benzoic acid phenylmethyl ester, benzy alcohol benzoic ester ATC code P03AX01 (WHO) QP53AX11 (WHO) Identifiers CAS Number 120-51-4 PubChem CID 2345 DrugBank DB02775 ChemSpider 13856959 UNII KEGG D01138 ChEBI CHEBI:41237 ChEMBL ChEMBL1239 CompTox Dashboard (EPA) DTXSID8029153 Edit this at Wikidata ECHA InfoCard 100.004.003 Edit this at Wikidata Chemical and physical data Formula C14H12O2 Molar mass 212.248 g·mol-1 3D model (JSmol) Interactive image 1.118 g/cm3 g/cm3 Melting point 18 °C (64 °F) Boiling point 323 °C (613 °F) Solubility in water insoluble mg/mL (20 °C) SMILES InChI Benzyl benzoate (BnBzO), sold under the brand name Scabanca among others, is a medication and insect repellent.[1] As a medication it is used to treat scabies and lice.[2] For scabies either permethrin or malathion is typically preferred.[3] It is applied to the skin as a lotion.[2] Typically two to three applications are needed.[2] Side effects may include irritation of the skin.[2] It is not recommended in children.[3] It is also used in other animals; however, is toxic to cats.[1] How it works is unclear.[4] Benzyl benzoate was first studied medically in 1918.[1] It is on the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system.[5] Benzyl benzoate is available as a generic medication.[3] The wholesale cost in the developing world is about US$0.21-0.53 per 100 mL.[6] It is not available for medical use in the United States.[1] In the United Kingdom it costs the NHS about £2.50 for 500 mL.[3]

Contents

1 Uses

1.1 Medical

1.2 Non-medical

2 Side effects

3 Chemistry

4 Production

5 References

Uses

Medical

Benzyl benzoate is an effective and inexpensive topical treatment for human scabies.[7] It has vasodilating and spasmolytic effects and is present in many asthma and whooping cough drugs.[8] It is also used as an excipient in some testosterone-replacement medications (like Nebido) for treating hypogonadism.[9] Benzyl benzoate is used as a topical acaricide, scabicide, and pediculicide in veterinary hospitals.[10] Non-medical Benzyl benzoate is used as a repellent for chiggers, ticks, and mosquitoes.[10] It is also used as a dye carrier, solvent for cellulose derivatives, plasticizer, and fixative in the perfume industry.[11] Side effects Benzyl benzoate has low acute toxicity in laboratory animals. It is rapidly hydrolyzed to benzoic acid and benzyl alcohol. Benzyl alcohol is subsequently metabolized to benzoic acid. The conjugates of benzoic acid (hippuric acid and the glucuronide of benzoic acid) are rapidly eliminated in urine.[1] When given in large doses to laboratory animals, benzyl benzoate can cause hyperexcitation, loss of coordination, ataxia, convulsions, and respiratory paralysis.[10] Benzyl benzoate can be a skin irritant when used as a topical scabicide.[7] Overdose can result in blistering and hives or a rash can occur as an allergic reaction.[12][13] As an excipient in some testosterone-replacement injectable medications, benzyl benzoate has been reported as a cause of anaphylaxis in a case in Australia.[14] Bayer includes this report in information for health professionals and recommends that physicians “should be aware of the potential for serious allergic reactions” to preparations of this type.[9] In Australia, reports to ADRAC, which evaluates reports of adverse drug reactions for the Therapeutic Goods Administration, show several reports of allergic issues since the anaphylaxis case from 2011.

Chemistry It is an organic compound with the formula C6H5CH2O2CC6H5. It is the ester of benzyl alcohol and benzoic acid. It forms either a viscous liquid or solid flakes and has a weak, sweet-balsamic odor. It occurs in a number of blossoms (e. g. tuberose, hyacinth) and is a component of Balsam of Peru and Tolu balsam.[11][15]

Production Benzyl benzoate is produced industrially by the reaction of sodium benzoate with benzyl alcohol in the presence of a base, or by transesterification of methyl benzoate and benzyl alcohol.[8] It is a byproduct of benzoic acid synthesis by toluene oxidation.[11] It can also be synthesized by the Tishchenko reaction, using benzaldehyde with sodium benzylate (generated from sodium and benzyl alcohol) as catalyst:[16][17]

The Tishchenko reaction: benzaldehyde reacts to benzyl benzoate, the catalyst is generated in situ from sodium and benzyl alcohol

Benzyl benzoate# Organophosphate Malathion Other/ungrouped DimethiconeQuassiatoluidine (Crotamiton) #WHO-EM‡Withdrawn from marketClinical trials: †Phase III§Never to phas COMPOUND SUMMARY Benzyl benzoate PubChem CID: 2345 : Benzyl benzoate_small.png Benzyl benzoate_3D_Structure.png Find Similar Structures Chemical Safety: Irritant Environmental Hazard Laboratory Chemical Safety Summary (LCSS) Datasheet Molecular Formula: C14H12O2 Chemical Names: BENZYL BENZOATE 120-51-4 Ascabiol Benylate NovoscabinMore… Molecular Weight: 212.24 g/mol Dates: Modify: 2019-09-14 Create: 2005-03-25 Benzyl benzoate is a benzoate ester obtained by the formal condensation of benzoic acid with benzyl alcohol. It has been isolated from the plant species of the genus Polyalthia. It has a role as a scabicide, an acaricide and a plant metabolite. It is a benzyl ester and a benzoate ester. It derives from a benzoic acid.

Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties. from DrugBank Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties. from Human Metabolome Database (HMDB) 1Structures HelpNew Window 1.12D Structure HelpNew Window Find Similar Structures Get Image DownloadChemical Structure Depiction Benzyl benzoate.png COMPOUND SUMMARY Benzyl benzoate PubChem CID: 2345 Structure: Benzyl benzoate_small.png Benzyl benzoate_3D_Structure.png Find Similar Structures Chemical Safety: Irritant Environmental Hazard Laboratory Chemical Safety Summary (LCSS) Datasheet Molecular Formula: C14H12O2 Chemical Names: BENZYL BENZOATE 120-51-4 Ascabiol Benylate Novoscabin More… Molecular Weight: 212.24 g/mol Dates: Modify: 2019-09-14 Create: 2005-03-25

Benzyl benzoate is a benzoate ester obtained by the formal condensation of benzoic acid with benzyl alcohol. It has been isolated from the plant species of the genus Polyalthia. It has a role as a scabicide, an acaricide and a plant metabolite. It is a benzyl ester and a benzoate ester. It derives from a benzoic acid. from ChEBI Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties. from DrugBank Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties. from Human Metabolome Database (HMDB) 1Structures HelpNew Window 1.12D Structure HelpNew Window Find Similar Structures Get Image Chemical Structure Depiction Benzyl benzoate.png Full screen Zoom in Zoom out from PubChem 1.23D Conformer HelpNew Window Get Image Download Interactive Chemical Structure Model Ball and Stick Sticks Wire-Frame Space-Filling Show Hydrogens Animate Full screen Zoom in out from PubChem 1.3Crystal Structures HelpNew Window PDBe Ligand Code BZM PDBe Structure Code 1DZM PDBe Conformer More Actions Menu Chemical Structure Model Ball and StickSticksWire-FrameSpace-Filling Show Hydrogens Animate Full screenZoom in Zoom out from Protein Data Bank in Europe (PDBe) 2Names and Identifiers HelpNew Window 2.1Computed Descriptors HelpNew Window 2.1.1IUPAC Name HelpNew Window benzyl benzoate from PubChem 2.1.2InChI HelpNew Window InChI=1S/C14H12O2/c15-14(13-9-5-2-6-10-13)16-11-12-7-3-1-4-8-12/h1-10H,11H2 rom PubChem 2.1.3InChI Key HelpNew Window SESFRYSPDFLNCH-UHFFFAOYSA-N from PubChem 2.1.4Canonical SMILES HelpNew Window C1=CC=C(C=C1)COC(=O)C2=CC=CC=C2 from PubChem 2.2Molecular Formula HelpNew Window C14H12O2 from ILO International Chemical Safety Cards (ICSC); PubChem2.3Other Identifiers HelpNew Window 2.3.1CAS HelpNew Window 120-51-4 from ChemIDplus; DrugBank; DTP/NCI; EPA Chemicals under the TSCA; EPA DSSTox; European Chemicals Agency (ECHA); HSDB; Human Metabolome Database (HMDB); ILO International Chemical Safety Cards (ICSC); The National Institute for Occupational Safety and Health (NIOSH) 2.3.2European Community (EC) Number HelpNew Window 204-402-9 from European Chemicals Agency (ECHA) 2.3.3FEMA Number HelpNew Window 2138 from Flavor and Extract Manufacturers Association (FEMA) 2.3.4ICSC Number HelpNew Window 0390 from ILO International Chemical Safety Cards (ICSC) Number HelpNew Window 758204 from DTP/NCI 8081 from DTP/NCI 2.3.6RTECS Number HelpNew Window DG4200000 from The National Institute for Occupational Safety and Health (NIOSH) 2.3.7UNII HelpNew Window N863NB338G from FDA/SPL Indexing Data 2.3.8Wikipedia HelpNew Window Benzyl benzoate from Wikipedia 2.4Synonyms HelpNew Window 2.4.1MeSH Entry Terms HelpNew Window Acaril Acarosan Ansar Antiscabiosum Ascabiol Benzanil Benzemul benzyl benzoate Benzylbenzoaat Smeersel FNA Novoscabin from MeSH 2.4.2Depositor-Supplied Synonyms HelpNew Window BENZYL BENZOATE 120-51-4 Ascabiol Benylate Novoscabin Benzoic acid benzyl ester Benzoic acid, phenylmethyl ester Ascabin Scabitox Scobenol Benzyl phenylformate Phenylmethyl benzoate Benzoic acid, benzyl ester Colebenz Peruscabin Scabagen ScabancaScabiozon Vanzoate Scabide Benzyl benzenecarboxylate benzylbenzoate Antiscabiosum benzoas Benzyl alcohol benzoic ester Peruscabina Spasmodin Venzonate Benzylum benzoicum Benzylester kyseliny benzoove Benzoesaeurebenzylester

BENZOIC ACID PHENYLMETHYLESTER

Caswell No. 082 Benzylbenzenecarboxylate Venzoate FEMA Number 2138 Benzyl benzoate (natural) 8081 UNII-N863NB338G FEMA No. 2138 HSDB 208 EINECS 204-402-9 MFCD00003075 Benzylester kyseliny benzoove [Czech] EPA Pesticide Chemical Code 009501 BRN 2049280 CHEMBL1239 AI3-00523 CHEBI:41237 SESFRYSPDFLNCH-UHFFFAOYSA-N N863NB338G NCGC00094981-03 Benzyl benzoate, 99+% DSSTox_CID_9153 DSSTox_RID_78686 DSSTox_GSID_29153 Benzyl benzoate, analytical standard Benzoate de benzyle BZM CAS-120-51-4 SMR000471875 Benzyl benzoate [USP:JAN] Acarobenzyl Benzevan benzyl-benzoate Benzyl benzoate [USAN:JAN] Benzyl benzoat Benzoic acid phenylmethyl ester Benzyl ester 1dzm Benylate (TN) Benzoesaurebenzylester Spectrum_001240 Benzoic acid-benzyl ester Spectrum2_000532 Spectrum3_001757 Spectrum4_000773 Spectrum5_001128 Benzyl benzoate 99+ % ACMC-1C8AP WLN: RVO1R Benzyl benzoate, >=99% EC 204-402-9 AC1L1DH0 SCHEMBL3038 BENZYL BENZOATE BP98 BSPBio_003494 KBioGR_001186 KBioSS_001720 -09-00-00307 (Beilstein Handbook Reference) KSC174Q0R MLS001066412 MLS001336003 MLS001336004 DivK1c_000204 SPECTRUM1503002 SPBio_000543 Benzyl benzoate (JP17/USP) AC1Q661C ZINC1021 DTXSID8029153 BENZOIC ACID,BENZYL ESTER CTK0H4808 HMS500K06 KBio1_000204 KBio2_001720 KBio2_004288 KBio2_006856 KBio3_002714 KS-00000UHX NSC8081 NINDS_000204 HMS1921P16 HMS2092F20 HMS2269D24 Pharmakon1600-01503002 HY-B0935 NSC-8081 Tox21_111372 Tox21_201337 Tox21_303418 ANW-17509 CCG-39578 NSC758204 s4599 SBB058609 STL183088 AKOS003495939 Benzyl benzoate, >=99%, FCC, FG Tox21_111372_1 DB00676 LS-2573 MCULE-4369643785 NSC-758204 RL00855 RTR-003391 IDI1_000204 Benzyl benzoate, for synthesis, 99.0% NCGC00094981-01NCGC00094981-02 NCGC00094981-04 NCGC00094981-05 NCGC00094981-07 NCGC00257502-01 NCGC00258889-01 AC-17033 AK308304 AN-22825 ZB000222 SBI-0051748.P002 DB-041563 TR-003391 B0064 FT-0622708 ST50406335 Benzyl benzoate, natural, >=99%, FCC, FG benzoate, ReagentPlus(R), >=99.0% Benzyl benzoate, SAJ first grade, >=98.0% Benzyl benzoate, tested according to Ph.Eur. A14577 A19449 Benzyl benzoate, SAJ special grade, >=99.0% C12537 D01138 AB00052298_07 Benzyl benzoate, Vetec(TM) reagent grade, 98% Benzyl benzoate, meets USP testing specifications

SR-01000763773 Benzoic acid-benzyl ester 5000 microg/mL in Hexane I14-6951 Q-200696 SR-01000763773-2 BRD-K52072429-001-06-1 Benzoic acid benzyl ester; Benzoic acid phenylmethyl ester Benzyl benzoate, certified reference material, TraceCERT(R) Benzyl benzoate, United States Pharmacopeia (USP) Reference Standard Benzyl benzoate, Pharmaceutical Secondary Standard; Certified Reference Material InChI=1/C14H12O2/c15-14(13-9-5-2-6-10-13)16-11-12-7-3-1-4-8-12/h1-10H,11H from PubChem 3Chemical and Physical Properties HelpNew Window 3.1Computed Properties HelpNew Window Property Name Property Value Molecular Weight 212.24 g/mol XLogP3 4 Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2 Rotatable Bond Count 4 Exact Mass 212.08373 g/mol Monoisotopic Mass 212.08373 g/mol Topological Polar Surface Area 26.3 A^2 Heavy Atom Count 16 Formal Charge 0 Complexity 213 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 Covalently-Bonded Unit Count 1 Compound Is Canonicalized Yes from PubChem 3.2Experimental Properties HelpNew Window 3.2.1Physical Description HelpNew Window Liquid; OtherSolid rom EPA Chemicals under the TSCA Solid rom Human Metabolome Database (HMDB) COLOURLESS LIQUID OR WHITE SOLID WITH CHARACTERISTIC ODOUR. from ILO International Chemical Safety Cards (ICSC) 3.2.2Color/Form HelpNew Window Leaflets or oily liquid O’Neil, M.J. (ed.). The Merck Index – An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 199 from HSDB Water-white liquid Larranaga, M.D., Lewis, R.J. Sr., Lewis, R.A.; Hawley’s Condensed Chemical Dictionary 16th Edition. John Wiley & Sons, Inc. Hoboken, NJ 2016., p. 159 from HSDB Colorless, oily liquid Lewis, R.J. Sr. (ed) Sax’s Dangerous Properties of Industrial Materials. 12th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2012., p. V2: 474 from HSDB Clear, colorless liquid Osol, A. and J.E. Hoover, et al. (eds.). Remington’s Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1179 from HSDB 3.2.3Odor HelpNew Window Light, balsamic odor reminiscent of almond Burdock, G.A. (ed.). Fenaroli’s Handbook of Flavor Ingredients. 6th ed.Boca Raton, FL 2010, p. 145 from HSDB Faint, pleasant, aromatic odor O’Neil, M.J. (ed.). The Merck Index – An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 199 from HSDB 3.2.4Taste HelpNew Window Sharp burning taste , M.J. (ed.). The Merck Index – An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 199 from HSDB 3.2.5Boiling Point HelpNew Window 323.5 °C PhysProp from DrugBank 323.5°C from EPA DSSTox 321.3 deg C Haynes, W.M. (ed.). CRC Handbook of Chemistry and Physics. 95th Edition. CRC Press LLC, Boca Raton: FL 2014-2015, p. 3-44 from HSDB 324 °C from ILO International Chemical Safety Cards (ICSC) 3.2.6Melting Point HelpNew Window 21 °C PhysProp from DrugBank 21.0°C from EPA DSSTox 19 deg C Haynes, W.M. (ed.). CRC Handbook of Chemistry and Physics. 95th Edition. CRC Press LLC, Boca Raton: FL 2014-2015, p. 3-44 Sigma-Aldrich; Safety Data Sheet for Benzyl benzoate. Product Number: B6630, Version 4.12 (Revision Date 06/20/2017). Available from, as of December 18, 2018: http://www.sigmaaldrich.com/safety-center.html Sigma-Aldrich; Safety Data Sheet for Benzyl benzoate. Product Number: B6630, Version 4.12 (Revision Date 06/20/2017). Available from, as of December 18, 2018: http://www.sigmaaldrich.com/safety-center.html

COMPOUND SUMMARY

Benzyl benzoate

PubChem CID: 2345

Structure:

Benzyl benzoate_small.png

Benzyl benzoate_3D_Structure.png

Find Similar Structures

Chemical Safety:

Irritant Environmental Hazard

2.2Molecular Formula HelpNew Window

C14H12O2 from ILO International Chemical Safety Cards (ICSC); PubChem 2.3Other Identifiers HelpNew Window 2.3.1CAS HelpNew Window 120-51-4 from ChemIDplus; DrugBank; DTP/NCI; EPA Chemicals under the TSCA; EPA DSSTox; European Chemicals Agency (ECHA); HSDB; Human Metabolome Database (HMDB); ILO International Chemical Safety Cards (ICSC); The National Institute for Occupational Safety and Health (NIOSH) 2.3.2European Community (EC) Number HelpNew Window 204-402-9 from European Chemicals Agency (ECHA) 2.3.3FEMA Number HelpNew Window 2138 from Flavor and Extract Manufacturers Association (FEMA) 2.3.4ICSC Number HelpNew Window 0390 from ILO International Chemical Safety Cards (ICSC) 2.3.5NSC Number HelpNew Window 758204 from DTP/NCI 8081 from DTP/NCI 2.3.6RTECS Number HelpNew Window DG4200000 from The National Institute for Occupational Safety and Health (NIOSH) 2.3.7UNII HelpNew Window N863NB338G from FDA/SPL Indexing Data 2.3.8Wikipedia HelpNew Window Benzyl benzoate rom Wikipedia 2.4Synonyms HelpNew Window 2.4.1MeSH Entry Terms HelpNew Window Acaril Acarosan Ansar Antiscabiosum Ascabiol Benzanil Benzemul benzyl benzoate Benzylbenzoaat Smeersel FNA Novoscabin from MeSH 2.4.2Depositor-Supplied Synonyms HelpNew Window BENZYL BENZOATE 120-51-4 Ascabiol Benylate Novoscabin Benzoic acid benzyl ester Benzoic acid, phenylmethyl ester Ascabin Scabitox Scobenol Benzyl phenylformate Phenylmethyl benzoate Benzoic acid, benzyl ester Benzylets Colebenz Peruscabin Scabagen Scabanca Scabiozon Vanzoate Scabide Benzyl benzenecarboxylate benzylbenzoate Antiscabiosum Benzylis benzoas Benzyl alcohol benzoic ester Peruscabina Spasmodin VenzonateBenzylum benzoicum Benzylester kyseliny benzoove Benzoesaeurebenzylester

BENZOIC ACID PHENYLMETHYLESTER

Caswell No. 082 Benzylbenzenecarboxylate Venzoate FEMA Number 2138 Benzyl benzoate (natural) NSC 8081 UNII-N863NB338G FEMA No. 2138 HSDB 208 EINECS 204-402-9 MFCD00003075 Benzylester kyseliny benzoove [Czech] EPA Pesticide Chemical Code 009501 BRN 2049280 CHEMBL1239 AI3-00523 CHEBI:41237 SESFRYSPDFLNCH-UHFFFAOYSA-N N863NB338G NCGC00094981-03 Benzyl benzoate, 99+% DSSTox_CID_9153 DSSTox_RID_78686 DSSTox_GSID_29153 Benzyl benzoate, analytical standard Benzoate de benzyle BZM CAS-120-51-4 SMR000471875 benzylbenzoat Benzyl benzoate [USP:JAN] Acarobenzyl Benzevan benzyl-benzoate Benzyl benzoate [USAN:JAN] Benzyl benzoat Benzoic acid phenylmethyl esterBenzyl ester 1dzm Benylate (TN) Benzoesaurebenzylester Spectrum_001240 Benzoic acid-benzyl ester Spectrum2_000532 Spectrum3_001757 Spectrum4_000773 Spectrum5_001128 Benzyl benzoate 99+ % ACMC-1C8AP WLN: RVO1R Benzyl benzoate, >=99% EC 204-402-9 AC1L1DH0 SCHEMBL3038 BENZYL BENZOATE BP98 BSPBio_003494 KBioGR_001186 KBioSS_001720 4-09-00-00307 (Beilstein Handbook Reference) KSC174Q0RMLS001066412 MLS001336003MLS001336004 DivK1c_000204 SPECTRUM1503002 SPBio_000543 Benzyl benzoate (JP17/USP) AC1Q661C ZINC1021 DTXSID8029153 BENZOIC ACID,BENZYL ESTER CTK0H4808HMS500K06 KBio1_000204 KBio2_001720 KBio2_004288 KBio2_006856 KBio3_002714 KS-00000UHX NSC8081 NINDS_000204 HMS1921P16 HMS2092F20 HMS2269D24 Pharmakon1600-01503002 HY-B0935 NSC-8081 ox21_111372 Tox21_201337 Tox21_303418 ANW-17509 BDBM50134035 CCG-39578 NSC758204 s4599 SBB058609 STL183088 AKOS003495939 Benzyl benzoate, >=99%, FCC, FG Tox21_111372_1 DB00676 LS-2573 MCULE-4369643785 NSC-758204 RL00855 RTR-003391 Benzyl benzoate, for synthesis, 99.0% NCGC00094981-01 NCGC00094981-02 NCGC00094981-04 NCGC00094981-05 NCGC00094981-07 NCGC00257502-01 NCGC00258889-01 AC-17033 AK308304 AN-22825 ZB000222 SBI-0051748.P002 DB-041563 TR-003391B0064 FT-0622708 ST50406335 Benzyl benzoate, natural, >=99%, FCC, FG Benzyl benzoate, ReagentPlus(R), >=99.0% Benzyl benzoate, SAJ first grade, >=98.0% Benzyl benzoate, tested according to Ph.Eur. A14577 A19449 Benzyl benzoate, SAJ special grade, >=99.0% C12537 D01138 AB00052298_07 Benzyl benzoate, Vetec(TM) reagent grade, 98% Benzyl benzoate, meets USP testing specifications SR-01000763773 Benzoic acid-benzyl ester 5000 microg/mL in Hexane I14-6951 Q-200696 SR-01000763773-2 BRD-K52072429-001-06-1 Benzoic acid benzyl ester; Benzoic acid phenylmethyl ester Benzyl benzoate, certified reference material, TraceCERT(R) Benzyl benzoate, United States Pharmacopeia (USP) Reference Standard Benzyl benzoate, Pharmaceutical Secondary Standard; Certified Reference Material InChI=1/C14H12O2/c15-14(13-9-5-2-6-10-13)16-11-12-7-3-1-4-8-12/h1-10H,11H from PubChem 3Chemical and Physical Properties HelpNew Window 3.1Computed Properties HelpNew Window Property Name Property Value Molecular Weight 212.24 g/mol XLogP3 4 Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2 Rotatable Bond Count 4 Exact Mass 212.08373 g/mol Monoisotopic Mass 212.08373 g/mol Topological Polar Surface Area 26.3 A^2 Heavy Atom Count 16 Formal Charge 0 Complexity 213

Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 Covalently-Bonded Unit Count 1 Compound Is Canonicalized Yes from PubChem 3.2Experimental Properties HelpNew Window 3.2.1Physical Description HelpNew Window Liquid; OtherSolid from EPA Chemicals under the TSCA Solid from Human Metabolome Database (HMDB) COLOURLESS LIQUID OR WHITE SOLID WITH CHARACTERISTIC ODOUR. from ILO International Chemical Safety Cards (ICSC) 3.2.2Color/Form HelpNew Window Leaflets or oily liquid O’Neil, M.J. (ed.). The Merck Index – An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 199 from HSDB Water-white liquid Larranaga, M.D., Lewis, R.J. Sr., Lewis, R.A.; Hawley’s Condensed Chemical Dictionary 16th Edition. John Wiley & Sons, Inc. Hoboken, NJ 2016., p. 159 from HSDB Colorless, oily liquid Lewis, R.J. Sr. (ed) Sax’s Dangerous Properties of Industrial Materials. 12th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2012., p. V2: 474 from HSDB Clear, colorless liquid , A. and J.E. Hoover, et al. (eds.). Remington’s Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1179 from HSDB 3.2.3Odor HelpNew Window Light, balsamic odor reminiscent of almond Burdock, G.A. (ed.). Fenaroli’s Handbook of Flavor Ingredients. 6th ed.Boca Raton, FL 2010, p. 145 from HSDB Faint, pleasant, aromatic odor O’Neil, M.J. (ed.). The Merck Index – An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 199 from HSDB 3.2.4Taste HelpNew Window Sharp burning taste , M.J. (ed.). The Merck Index – An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 199from HSDB 3.2.5Boiling Point HelpNew Window 323.5 °C PhysProp from DrugBank 323.5°C from EPA DSSTox 321.3 deg C Haynes, W.M. (ed.). CRC Handbook of Chemistry and Physics. 95th Edition. CRC Press LLC, Boca Raton: FL 2014-2015, p. 3-44 from HSDB 324 °C from ILO International Chemical Safety Cards (ICSC) 3.2.6Melting Point HelpNew Window 21 °C PhysProp from DrugBank 21.0°C from EPA DSSTox 19 deg C Haynes, W.M. (ed.). CRC Handbook of Chemistry and Physics. 95th Edition. CRC Press LLC, Boca Raton: FL 2014-2015, p. 3-44 HSDB 21°C from Human Metabolome Database (HMDB) 21 °C from ILO International Chemical Safety Cards (ICSC) 3.2.7Flash Point HelpNew Window 158 deg C (316 deg F) – closed cup Sigma-Aldrich; Safety Data Sheet for Benzyl benzoate. Product Number: B6630, Version 4.12 (Revision Date 06/20/2017). Available from, as of December 18, 2018: http://www.sigmaaldrich.com/safety-center.html from HSDB 298 deg F (148 deg C) – closed cup National Fire Protection Association; Fire Protection Guide to Hazardous Materials. 14TH Edition, Quincy, MA 2010, p. 325-18 from HSDB 148 °C from ILO International Chemical Safety Cards (ICSC) 3.2.8Solubility HelpNew Window 15.4 mg/L from DrugBank In water, 25 mg/L at 25 deg C (est)

US EPA; Estimation Program Interface (EPI) Suite. Ver. 4.11. Nov, 2012. Available from, as of Oct 3, 2018: http://www2.epa.gov/tsca-screening-tools from HSDB Insoluble in water O’Neil, M.J. (ed.). The Merck Index – An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 199 from HSDB Insoluble in glycerol; miscible with alcohol, chloroform, ether, oils O’Neil, M.J. (ed.). The Merck Index – An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 199 from HSDB Soluble in ethanol, ethyl ether, acetone, benzene, methanol, chloroform Haynes, W.M. (ed.). CRC Handbook of Chemistry and Physics. 95th Edition. CRC Press LLC, Boca Raton: FL 2014-2015, p. 3-44 from HSDB 1.98e-02 g/L Human Metabolome Database (HMDB) Solubility in water: none rom ILO International Chemical Safety Cards (ICSC) 3.2.9Density HelpNew Window 1.1121 g/cu cm at 25 deg C Haynes, W.M. (ed.). CRC Handbook of Chemistry and Physics. 95th Edition. CRC Press LLC, Boca Raton: FL 2014-2015, p. 3-44 from HSDB Relative density (water = 1): 1.1 from ILO International Chemical Safety Cards (ICSC) 3.2.10Vapor Density HelpNew Window 7.31 (Air = 1) Lide, D.R., G.W.A. Milne (eds.). Handbook of Data on Organic Compounds. Volume I. 3rd ed. CRC Press, Inc. Boca Raton ,FL. 1994., p. V2: 474 from HSDB Relative vapor density (air = 1): 7.3 from ILO International Chemical Safety Cards (ICSC) 3.2.11Vapor Pressure HelpNew Window 2.24e-04 mmHg from EPA DSSTox 0.000224 mm Hg at 25 deg C Daubert, T.E., R.P. Danner. Physical and Thermodynamic Properties of Pure Chemicals Data Compilation. Washington, D.C.: Taylor and Francis, 1989. from HSDB 3.2.12Octanol/Water Partition Coefficient HelpNew Window 3.97 HANSCH,C ET AL. (1995) from DrugBank 3.97 (LogP) HANSCH,C ET AL. (1995) from EPA DSSTox Kow = 3.97 Hansch, C., Leo, A., D. Hoekman. Exploring QSAR – Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995., p. 120 from HSDB LogP 3.7 from Human Metabolome Database (HMDB) LogP from ILO International Chemical Safety Cards (ICSC) 3.2.13Stability/Shelf Life HelpNew Window Stable under recommended storage conditions. Sigma-Aldrich; Safety Data Sheet for Benzyl benzoate. Product Number: B6630, Version 4.12 (Revision Date 06/20/2017). Available from, as of December 18, 2018: http://www.sigmaaldrich.com/safety-center.html

Benzyl benzoate should not be applied to acutely inflamed skin or raw, weeping surfaces. If primary irritation or hypersensitivity occurs, treatment should be discontinued and the drug removed with soap and water.

Comments No safety concern at current levels of intake when used as a flavouring agent. The 1996 group ADI of 0-5 mg/kg bw for benzoic acid, the benzoate salts (calcium, potassium and sodium), benzaldehyde, benzyl acetate, benzyl alcohol and benzyl benzoate, expressed as benzoic acid equivalents, was maintained at the fifty-seventh meeting (2001).

Report TRS 909-JECFA 57/73

from FAO/WHO Food Additive Evaluations (JECFA)

9Agrochemical Information HelpNew Window

9.1Agrochemical Category HelpNew Window

Miticide

from USGS Columbia Environmental Research Center

10Pharmacology and Biochemistry HelpNew Window

10.1Pharmacology HelpNew Window

from DrugBank

10.2MeSH Pharmacological Classification HelpNew Window

Insecticides

Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics. (See all compounds classified as Insecticides.) from MeSH 10.3ATC Code HelpNew Window P – Antiparasitic products, insecticides and repellents P03 – Ectoparasiticides, incl. scabicides, insecticides and repellents P03A – Ectoparasiticides, incl. scabicides P03AX – Other ectoparasiticides, incl. scabicides P03AX01 – Benzyl benzoate from WHO ATC 10.4Absorption, Distribution and Excretion New Window Absorption No data are available on percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however the amount was not quantified. from DrugBank

The maternal and fetal toxicity of benzyl benzoate, commonly used as antiparasitic insecticide, was evaluated in pregnant rats after a daily oral dose of 25 and 100 mg/kg. Biochemical, histopathological, and morphological examinations were performed. Dams were observed for maternal body weights and food and water consumption and subjected to caesarean section on (GD) 20. Maternal and fetal liver, kidney, heart, brain, and placenta were examined histopathologically under light microscope. Maternal and fetal liver and placenta were stained immunohistochemically for vascular endothelial growth factor (VEGF). Morphometric analysis of fetal body lengths, placental measurements, and fetal skeletal stainings was performed. Statistically significant alterations in biochemical parameters and placental and skeletal measurements were determined in treatment groups. In addition to histopathological changes, considerable differences were observed in the immunolocalization of VEGF in treatment groups. These results demonstrated that benzyl benzoate and its metabolites can transport to the placenta and eventually enter the fetuses.

PMID:21922633 Kockaya EA, Kilic A et al; Environ Toxicol 29 (1): 40-53 (2014) from HSDB The percutaneous absorption of benzyl benzoate measured in vivo in human and monkey studies. With the application sites occluded, 54% of the applied dose penetrated human skin in 24 hr compared with 69% absorption in the monkey skin. PMID:2379896 Bronaugh RL et al; Food Chem Toxicol 28 (5): 369-74 (1990) from HSDB 10.5Metabolism/Metabolites HelpNew Window Rapidly hydrolyzed to benzoic acid and benzyl alcohol, which is further oxidized to benzoic acid. The benzoic acid is conjugated with glycine to form hippuric acid. from DrugBank Converted to hippuric acid in vivo. Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-203 from HSDB 10.6Mechanism of Action HelpNew Window Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes. from DrugBank 10.7Human Metabolite Information HelpNew Window 10.7.1Metabolite Description HelpNew Window Description Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.

from Human Metabolome Database (HMDB) 10.7.2Cellular Locations HelpNew Window Membrane from Human Metabolome Database (HMDB) 10.8Biochemical Reactions HelpNew Window 1 item View More Details Download Rhea Accession Reaction RHEA:30411 benzoyl-CoA + benzyl alcohol = CoA + benzyl benzoate from Rhea – annotated reactions database 11Use and Manufacturing HelpNew Window 11.1Overview HelpNew Window IDENTIFICATION: Benzyl benzoate is a colorless oily liquid. It can also be in the form of leaflets. It has an almond taste and a pleasant odor. It is nearly insoluble in water. Benzyl benzoate occurs in many plants and essential oils. USE: Benzyl benzoate is an important commercial chemical. It is used in making plastics, as a solvent, in making other chemicals, as a food flavoring, and in perfumes. It is also used as a skin medication for humans and dogs in treating mites. Benzoyl benzoate is used to control dust mites in carpets and furniture. EXPOSURE: Workers who use benzyl benzoate may breathe in vapors or have direct skin contact. The general population may be exposed by vapors, dermal contact, and consumption of food containing benzyl benzoate. If benzyl benzoate is released to the environment, it will be broken down in air. It may be broken down by sunlight. It will not move into air from moist soil and water. It is not expected to move through soil. It will be broken down by microorganisms and is expected to build up in fish. RISK: The World Health Organization Joint Expert Committee on Food Additives determined that the flavoring agent benzyl benzoate does not pose any health risks at levels used in food. Irritation of the skin, eyes, and respiratory tract may occur following exposure to benzyl benzoate on the skin or in the air. Severe coughing, asthma attacks and rashes were reported in some asthma sufferers exposed to benzoyl benzoate in mite control consumer products. Nervous system toxicity (staggering, decreased activity, drowsiness, decreased breathing rate, brain lesions), damage to the thymus, kidneys, and skeletal muscle, decreased body weight, and internal bleeding were reported in laboratory animals following repeated exposure to very high oral doses of benzyl benzoate. Some animals died. No evidence of abortion or birth defects were observed in laboratory animals exposed to benzyl benzoate during pregnancy. Decreased fetal body weight and altered bone development were observed at very high dose levels. Data on the potential for benzyl benzoate to cause infertility were not available. Data on the potential for benzyl benzoate to cause cancer in laboratory animals were not available. However, no tumors were induced in laboratory animals exposed to benzyl alcohol, which is the main chemical breakdown product of benzyl benzoate in the human body. The potential for benzyl benzoate to cause cancer in humans has not been assessed by the U.S. EPA IRIS program, the International Agency for Research on Cancer, or the U.S. National Toxicology Program 14th Report on Carcinogens. The U.S. EPA Office of Pesticides Program determined that benzyl benzoate is not expected to be carcinogenic based on no evidence of carcinogenicity in laboratory animals exposed to its breakdown product benzyl alcohol. (SRC)

FOR MORE INFORMATION: (1) National Library of Medicine Hazardous Substances Data Bank. Available from, as of Oct 4, 2018: http://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm (2) Center for Disease Control and Prevention Agency for Toxic Substances and Disease Registry. Available from, as of Oct 4, 2018: http://www.cdc.gov/ (3) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Available from, as of Oct 4, 2018: http://monographs.iarc.fr/ENG/Classification/index.php (4) National Library of Medicine. Household Products Database. Available from, as of Oct 4, 2018: http://hpd.nlm.nih.gov/ (5) National Toxicology Program. 2016. Report on Carcinogens, 14th ed., Research Triangle Park, NC: US Dept Health Human Serv, Public Health Serv. Available from, as of Oct 4, 2018: https://ntp.niehs.nih.gov/pubhealth/roc/index-1.html (6) National Library of Medicine. MedlinePlus. Benzyl benzoate. Available from, as of Oct 4, 2018: https://medlineplus.gov (7) National Library of Medicine PubMed. Available from, as of Oct 4, 2018: http://www.ncbi.nlm.nih.gov/pubmed (8) USEPA; Chemical Data Reporting (CDR). Non-confidential 2016 Chemical Data Reporting information on chemical production and use in the United States. Available from, as of Oct 5, 2018: https://chemview.epa.gov/chemview# (9) USEPA/IRIS Integrated Risk Information System. Available from, as of Oct 4, 2018: http://www.epa.gov/iris/ (10) USEPA/OPPTS; Reregistration Eligibility Decisions (REDs) for Benzyl Benzoate (Benzoic Acid case 4013) June 26, 2007. Available from, as of Oct 4, 2018: http://iaspub.epa.gov/apex/pesticides/f?p=chemicalsearch:1 (11) US FDA. Everything Added to Food in the United States (EAFUS). November 2011. Benzyl benzoate (120-51-4). Available from, as of Oct 4, 2018: http://www.accessdata.fda.gov/scripts/fcn/fcnNavigation.cfm?rpt=eafusListing (12) WHO; Safety evaluation of certain food additives and contaminants. WHO Food Additives Series 48. Geneva, Switzerland: World Health Org 2002. Available from, as of Dec 20, 2018: http://apps.who.int/iris/bitstream/handle/10665/42501/9241660481_en.pdf?sequence=1&ua=1

from HSDB 11.2Use Classification HelpNew Window JECFA Functional Classes Flavouring Agent: FLAVOURING_AGENT Food Additives: CARRIER_SOLVENT from FAO/WHO Food Additive Evaluations (JECFA) Household Products Categories Inside the Home; Personal care; Pet Care from NLM Household Products Database Use Classification Acaricide from USGS Columbia Environmental Research Center 11.3Household Products HelpNew Window NLM Household Products and Categories Glade Candle 2-IN-1, Sunny Day and Clean Linen-02/24/2015 [Inside the Home] LOreal Feria Multi-Faceted Shimmering Colour 3X Highlights, Brilliant Bordeaux 56 [Personal care] Glade Tough Odor Solutions Carpet and Room Odor Eliminator, Clear Springs-02/24/2015 [Pet Care] … see the complete list of household products from NLM Household Products Database 11.4Uses HelpNew Window EPA CPDat Chemical and Product Categories 106 items View More Download SORT BY Descending

Category Category Category Description Categorization Type Absorbent Agent for soaking up liquid (product use or application unknown) CPCat Cassette Adsorbent Adhesion of molecules to a surface CPCat Cassette Air_fresheners, consumer_use, detected Chemicals detected in substances or products (note that these chemicals may be absent from an ‘ingredient list’ for the product and thus unexpected, but have been detected in product testing studies) CPCat Cassette Air_fresheners, fragrance, consumer_use Term applied when the only information the source indicates is ‘consumer’ or ‘consumer product’ ; also applied to terms that the source indicates are for consumer use, yet the descriptor term is ambivalent about usage (e.g., cleaning_washing products may be for industrial or consumer use, when the source indicates consumer use, the consumer_use term is also applied) – see appendix for full list of unambiguous consumer related terms plus ambiguous consumer related terms which if indicated are labeled with ‘consumer_use’ CPCat Cassette Air_treatment Air cleaners and anti-odor agents, air purifiers, air conditioners, air filters, general air care products CPCat Cassette Next The Chemical and Products Database, a resource for exposure-relevant data on chemicals in consumer products, Scientific Data, volume 5, Article number: 180125 (2018), DOI:10.1038/sdata.2018.125

from EU Food Improvement Agents

For benzyl benzoate (USEPA/OPP Pesticide Code: 009501) ACTIVE products with label matches. /SRP: Registered for use in the USA but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ National Pesticide Information Retrieval System’s Database on Benzyl Benzoate (120-51-4). Available from, as of January 15, 2019: http://npirspublic.ceris.purdue.edu/ppis/ from HSDB As solvent of cellulose acetate, nitrocellulose and artificual musk; substitute for camphor in celluloid and plastic pyroxylin compounds; perfume fixative; in confectionary and chewing gum flavors. O’Neil, M.J. (ed.). The Merck Index – An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 199 from HSDB Fixative and solvent for musk in perfumes and flavors; medicine (external); plasticizer for nitrocellulose and cellulose acetate, miticide. Larranaga, M.D., Lewis, R.J. Sr., Lewis, R.A.; Hawley’s Condensed Chemical Dictionary 16th Edition. John Wiley & Sons, Inc. Hoboken, NJ 2016., p. 159 from HSDB Reported uses (ppm): Table #819 Reported uses (ppm): (Flavor and Extract Manufacturers’ Association, 1994) Burdock, G.A. (ed.). Fenaroli’s Handbook of Flavor Ingredients. 6th ed.Boca Raton, FL 2010, p. 145 from HSDB Benzyl benzoate, a member of the benzyl derivative family, is an insecticide/miticide used to control dust mites in carpets, mattresses, upholstery, and on furniture … . USEPA/Office of Prevention, Pesticides and Toxic Substances; Reregistration Eligibility Decision Document – Benzyl Benzoate (Benzoic Acid case 4013) p.3, EPA-HQ-OPP-2007-0470-0002 (June 2007). Available from, as of December 19, 2018: https://iaspub.epa.gov/apex/pesticides/f?p=chemicalsearch:1 from HSDB Benzyl benzoate was used in the Vietnam War to eradicate and repel certain ticks and mites.

Opgrande JL et al; Benzoic Acid. Kirk-Othmer Encyclopedia of Chemical Technology (1999-2018). John Wiley & Sons, Inc. Online Posting Date: May 16, 2003 from HSDB MEDICATION from HSDB MEDICATION (VET) from HSDB 11.4.1Industry Uses HelpNew Window Dyes agents Solvents (for cleaning and degreasing) Solvents (which become part of product formulation or mixture) Surface active agents https://www.epa.gov/chemical-data-reporting from EPA Chemicals under the TSCA 11.4.2Consumer Uses HelpNew Window Air care products Cleaning and furnishing care products Fabric, textile, and leather products not covered elsewhere Laundry and dishwashing products Non-TSCA use Paper products Personal care products Plastic and rubber products not covered elsewhere aroma chemicals https://www.epa.gov/chemical-data-reporting from EPA Chemicals under the TSCA 11.5Methods of Manufacturing HelpNew Window Prepared by the action of sodium benzylate on benzaldehyde … ; by the dry esterification of sodium benzoate and benzyl chloride in the presence of triethylamine. O’Neil, M.J. (ed.). The Merck Index – An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 199 from HSDB Derivation: (a) By a Cannizzaro reaction from benzaldehyde, (b) by esterifying benzyl alcohol with benzoic acid, (c) by treating sodium benzoate with benzyl chloride. Method of purification: Distillation and crystallization. Larranaga, M.D., Lewis, R.J. Sr., Lewis, R.A.; Hawley’s Condensed Chemical Dictionary 16th Edition. John Wiley & Sons, Inc. Hoboken, NJ 2016., p. 159 from HSDB Benzyl benzoate is produced by esterifying dry sodium benzoate with benzyl chloride or by the dimerization of benzaldehyde. It is also obtained from the bottoms of benzoic acid rectification plants. Maki T, Takeda K; Benzoic Acid and Derivatives. Ullmann’s Encyclopedia of Industrial Chemistry 7th ed. (1999-2018). NY, NY: John Wiley & Sons. Online Posting Date: June 15, 2000 from HSDB Benzyl benzoate is produced from benzyl alcohol and sodium benzoate in the presence of triethylamine or transesterification of methyl benzoate with benzyl alcohol in the presence of an alkali benzyl oxide; in another manufacturing process benzaldehyde is condensed to form benzyl benzoate in the presence of sodium (Claisen-Tishchenko condensation) Bruhne F, Wright E; Benzyl Alcohol. Ullmann’s Encyclopedia of Industrial Chemistry 7th ed. (1999-2018). NY, NY: John Wiley & Sons. Online Posting Date: June 15, 2000 from HSDB By the dry esterification of sodium benzoate and benzoyl chloride in the presence of triethylamine or by reaction of sodium benzylate on benzaldehyde. Burdock, G.A. (ed.). Fenaroli’s Handbook of Flavor Ingredients. 6th ed.Boca Raton, FL 2010, p. 146 from HSDB 11.6Formulations/Preparations HelpNew Window #814 Benzyl Benzoate Preparations American Society of Health-System Pharmacists; Drug Information 2018. Bethesda, MD. 2018 from HSDB Acarosan Moist Powder (Allergopharma Joachim): Active ingredient: benylate 5.0%. National Pesticide Information Retrieval System’s Database on Benzyl Benzoate (120-51-4). Available from, as of January 15, 2019: http://npirspublic.ceris.purdue.edu/ppis/ from HSDB Sardex-II Dog Mange Remedy (Happy Jack Inc.): Active ingredient: benylate 29.0%. National Pesticide Information Retrieval System’s Database on Benzyl Benzoate (120-51-4). Available from, as of January 15, 2019: http://npirspublic.ceris.purdue.edu/ppis/ from HSDB

Benzyl benzoate is available as a ready-to-use powder and an aerosol (spray). USEPA/Office of Prevention, Pesticides and Toxic Substances; Reregistration Eligibility Decision Document – Benzyl Benzoate (Benzoic Acid case 4013) p.4, EPA-HQ-OPP-2007-0470-0002 (June 2007). Available from, as of December 19, 2018: https://iaspub.epa.gov/apex/pesticides/f?p=chemicalsearch:1 from HSDB Grade: Technical, USP, FCC. Larranaga, M.D., Lewis, R.J. Sr., Lewis, R.A.; Hawley’s Condensed Chemical Dictionary 16th Edition. John Wiley & Sons, Inc. Hoboken, NJ 2016., p. 159 from HSDB USEPA/OPP Pesticide Code 009501; Trade Names: Benylate. National Pesticide Information Retrieval System’s Database on Benzyl benzoate (120-51-4). Available from, as of October 24, 2002: http://npirspublic.ceris.purdue.edu/ppis/ from HSDB Liquid containing 30% technical Farm Chemicals Handbook 87. Willoughby, Ohio: Meister Publishing Co., 1987., p. C-36 From HSDB 11.7U.S. Production HelpNew Window Aggregated Product Volume (EPA CDR 2016) 1,000,000 – 10,000,000 lb https://www.epa.gov/chemical-data-reporting from EPA Chemicals under the TSCA (1972) 1.85X10+8 GRAMS SRI from HSDB (1975) 3.35X10+8 GRAMS SRI from HSDB (1991) 287,000 kg USITC; Synthetic Organic Chemicals – United States Production and Sales 1991, USITC Publication 2607, Washington,DC: US International Trade Commission p 7-2 (1993) from HSDB Non-confidential 2016 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Benzyl benzoate: Table #818 National Aggregate Production Volume (pounds) USEPA; 2016 Chemical Data Reporting Database. Benzyl Benzoate (120-51-4). Available from, as of January 16, 2019: https://www.epa.gov/chemical-data-reporting rom HSDB 11.8Manufacturers HelpNew Window Benzyl benzoate – Manufacturing and Production Data (2016) Table #815 5 of 16 Companies Listed in Source US EPA; Chemical Data Reporting (CDR). Non-confidential 2016 Chemical Data Reporting information on chemical production and use in the United States. Available from, as of Oct 3, 2018: http://java.epa.gov/oppt_chemical_search/ from HSDB Sigma-Aldrich, 3050 Spruce St., Saint Louis, MO 63103 Sigma-Aldrich; Product Search Benzyl benzoate (120-51-4). Available from, as of Oct 3, 2018: http://www.sigmaaldrich.com/united-states.html from HSDB Benzyl benzoate Registrants Table #816 National Pesticide Information Retrieval System’s Database on Benylate (120-51-4). Available from, as of Oct 3, 2018: http://npirspublic.ceris.purdue.edu/ppis/ from EPA Chemicals under the TSCA

Mosquitoes were not repelled by benzyl benzoate applied on vermiculite to 0.5 & 1 acre plots. Gorham JR; Mosq News 34 (4): 409 (1974) from HSDB Marketing status: Discontinued (50% strength; Emulsion; Topical) US FDA; Drugs@FDA: FDA Approved Drug Products. Benzyl Benzoate. Available from, as of Oct 3, 2018: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process from HSDB Benzyl benzoate is a byproduct in the manufacture of benzoic acid by the oxidation of toluene; it is present in the benzoic acid distillation residue. Bruhne F, Wright E; Benzyl Alcohol. Ullmann’s Encyclopedia of Industrial Chemistry 7th ed. (1999-2018). NY, NY: John Wiley & Sons. Online Posting Date: June 15, 2000 from HSDB 12Identification HelpNew Window 12.1Analytic Laboratory Methods HelpNew Window The development of a simple, shorter and more accurate method than the NF method for the determination of benzyl benzoate in Benzyl Benzoate Lotion NF is discussed. Hydrolyzed benzyl benzoate was measured spectrophotometrically. Interference from other ingredients of the lotion, oleic acid and triethanolamine was almost negligible. The proposed method was completed in approximately 15 minutes, as opposed to the two hours required by the NF procedure. PMID:941923 Gupta VD, Ho HW; Am J Hosp Pharm 33 (7): 665-6 (1976) from HSDB Eight constituents including benzyl benzoate were separated from jasmine concrete using SiO2 (Partisil 5) column chromatography with 97.5 to 2.5 (vol/vol) isooctane-ethyl acetate as mobile phase. Reversed-phase chromatography with grafted SiO2 (LiChrosorb RP18) as stationary phase and H2O-methanol (50/50 vol) as mobile phase was also used. Linossier JL et al; Analysis 10 (7): 310 (1982) from HSDB PMR procedure developed for quantitation of benzyl benzoate in Peru and tolu balsams. El-Obeid HA et al; Spectrosc Lett 13 (6): 361 (1980) from HSDB 13Safety and Hazards HelpNew Window 13.1Hazards Identification HelpNew Window 13.1.1GHS Classification HelpNew Window Showing 1 of 5 View More Pictogram(s) Irritant Environmental Hazard Signal Warning GHS Hazard Statements H302: Harmful if swallowed [Warning Acute toxicity, oral] H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statement Codes P264, P270, P273, P301+P312, P330, P391, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) from EU REGULATION (EC) No 1272/2008 13.1.2NFPA Hazard Classification HelpNew Window NFPA 704 Diamond 1-1-0 NFPA Health Rating 1 – Materials that, under emergency conditions, can cause significant irritation. NFPA Fire Rating 1 – Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. NFPA Instability Rating 0 – Materials that in themselves are normally stable, even under fire conditions. from HSDB 13.1.3Fire Hazard HelpNew Window Combustible. from ILO International Chemical Safety Cards (ICSC) 13.1.4Fire Potential HelpNew Window Combustible liquid. Lewis, R.J. Sr. (ed) Sax’s Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 380 from HSDB 13.1.5Skin, Eye, and Respiratory Irritations HelpNew Window Direct contact may cause skin irritation. O’Neil, M.J. (ed.). The Merck Index – An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 199 from HSDB Irritant to eyes, skin. Larranaga, M.D., Lewis, R.J. Sr., Lewis, R.A.; Hawley’s Condensed Chemical Dictionary 16th Edition. John Wiley & Sons, Inc. Hoboken, NJ 2016., p. 159 from HSDB

Sigma-Aldrich; Safety Data Sheet for Benzyl benzoate. Product Number: B6630, Version 4.12 (Revision Date 06/20/2017). Available from, as of December 18, 2018: http://www.sigmaaldrich.com/safety-center.html

from HSDB

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

from HSDB

13.6Handling and Storage HelpNew Window

13.6.1Safe Storage HelpNew Window

Ventilation along the floor.

from HSDB

Body Protection: Complete suit protecting against chemicals. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

from HSDB

Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Other HIGH concerns: Occupational hazards; Other LOW concerns: Ecotoxicology, Endocrine disruption

About BENZYL BENZOATE: Benzyl benzoate is used as solvent and preservative; associated with allergies and contact dermatitis.

Data Sources

CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP. Charles AK, Darbre PD. 2009. Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) n MCF7 human breast cancer cells in vitro. J Appl Toxicol. 29(5):422-34. EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ . FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition. IFRA (International Fragrance Association). 2006. Codes and Standards. FRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25 NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov. SCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 1999. Opinion Concerning Fragrance Allergy In Consumers. . SCCNFP/0017/98 Final, December 1999; and SCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 2000. An Initial List Of Perfumery Materials Which Must Not Form Part Of Fragrances Compounds Used In Cosmetic Products. SCCNFP/0320/00, final May 2000. About the Skin Deep® ratings EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product – not the product itself – compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer About EWG VERIFIEDTM

Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIEDTM mark as a quick and easily identifiable way of conveying personal care products that meet EWG’s strict health criteria. Before a company can use EWG VERIFIEDTM on such products, the company must show that it fully discloses the products’ ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED member companies that help to support the important work we do. Learn more | Legal Disclaimer Benzyl benzoate IDENTIFICATION Logo pink High-quality data is the first step for training Machine-Learning and Artificial Intelligence models. Learn more about DrugBank data. Name Benzyl benzoate Accession Number DB00676 (APRD00821, EXPT00792, DB02775) Type Small Molecule Groups Description Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.

Structure Thumb Synonyms Acarobenzyl Benylate Benzevan Benzoate de benzyle Benzoesäurebenzylester Benzoic acid phenylmethylester Benzoic acid, benzyl ester Benzoic acid, phenylmethyl ester Benzyl benzoat Benzylis benzoas Phenylmethyl benzoate External IDs FEMA NO. 2138 / NSC-8081 International/Other Brands Acaril-S (Medifarma) / Acarilbial (Bial) / Acarsan (Biosintética) / Acil (Didy Pharmaceutical) / Antiscabiosum (Strathmann) / Antiscabiosum für Kinder (Strathmann) / Ascabiol (Sanofi-Aventis) / Ascalol (Pharmaghreb) / B.B. Lotion (Washington) / BE BO (Aesculap) / Benzalcor (Corsalud) / Benzilbenzoat (Labor) / Benzogal (Rafarm) / Benzotal (Grindeks) / Bezo (Medisearch) / Finsarna (Qualicont) / Gensarna (Gencopharmaceutical) / Miticocan (Aché) / Novoscabin (Polon) / Opele (Beta Health Care) / Pharcobenzyl (Pharco) / Sanasar (Kley Hertz) / Saniscabis (Neo-Fármaco) / Scabicon (Medicon) / Scabiex (Rekah) / Scabin (Abdi Ibrahim) / Scabisol (Jayson) / Scabitox (Bosnalijek) / Spasmodine / Tekoce (Jadran) / Zilaben (Cristália) Categories Acaricides Acids, Carbocyclic Agrochemicals Antiparasitic Products, Insecticides and Repellents Benzene Derivatives Compounds used in a research, industrial, or household setting Ectoparasiticides, Incl. Scabicides Ectoparasiticides, Incl. Scabicides, Insecticides and Repellents Insecticides Pesticides Toxic Actions UNII N863NB338G CAS number 120-51-4 Weight Average: 212.2439 Monoisotopic: 212.083729628 Chemical Formula C14H12O2 InChI Key SESFRYSPDFLNCH-UHFFFAOYSA-N InChI InChI=1S/C14H12O2/c15-14(13-9-5-2-6-10-13)16-11-12-7-3-1-4-8-12/h1-10H,11H2 IUPAC Name benzyl SMILES O=C(OCC1=CC=CC=C1)C1=CC=CC=C1 PHARMACOLOGY Indication Used to kill lice and the mites responsible for the skin condition scabies.

Pharmacodynamics

Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties. Mechanism of action Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes. Absorption No data are available on percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however the amount was not quantified. Volume of distribution Not Available Protein binding Not Available Metabolism Rapidly hydrolyzed to benzoic acid and benzyl alcohol, which is further oxidized to benzoic acid. The benzoic acid is conjugated with glycine to form hippuric acid. Route of elimination Not Available Half life Not Available Clearance Not Available Oral, rabbit: LD50 = 1680 mg/kg; Skin, rabbit: LD50 = 4000 mg/kg. Symptoms of overdose include blister formation, crusting, itching, oozing, reddening, or scaling of skin; difficulty in urinating (dribbling); jerking movements; sudden loss of consciousness.

Affected organisms scabiei Pathways Not Available Pharmacogenomic Effects/ADRs Available INTERACTIONS Drug Interactions This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist. Not Available Food Interactions Not Available REFERENCES Synthesis Reference Henri Sidi, William G. Hughes, “Process for the production of benzoic acid from process residues that contain benzyl benzoate.” U.S. Patent US4281178, issued September, 1941. US4281178 General References Bachewar NP, Thawani VR, Mali SN, Gharpure KJ, Shingade VP, Dakhale GN: Comparison of safety, efficacy, and cost effectiveness of benzyl benzoate, permethrin, and ivermectin in patients of scabies. Indian J Pharmacol. 2009 Feb;41(1):9-14. doi: 10.4103/0253-7613.48882. [PubMed:20177574] Buffet M, Dupin N: Current treatments for scabies. Fundam Clin Pharmacol. 2003 Apr;17(2):217-25. [PubMed:12667233] External Link.

Benzyl benzoate 0.16USD ml

This compound belongs to the class of organic compounds known as benzoic acid esters. These are ester derivatives of benzoic acid. Kingdom Organic compounds Super Class Benzenoids Class Benzene and substituted derivatives Sub Class acids and derivatives Direct Parent Benzoic acid esters Alternative Parents Benzoyl derivatives / Carboxylic acid esters / Monocarboxylic acids and derivatives / Organooxygen compounds / Organic oxides / Hydrocarbon derivatives Substituents Benzyloxycarbonyl / Benzoate ester / Benzoyl / Carboxylic acid ester / Monocarboxylic acid or derivatives / Carboxylic acid derivative / Organic oxygen compound / Organic oxide / Hydrocarbon derivative / Organooxygen compound Molecular Framework Aromatic homomonocyclic compounds External Descriptors benzoate ester (CHEBI:41237) / a small molecule (CPD-6443) Drugs A to Z Benzyl benzoate (Topical) Print Share Benzyl benzoate (Topical) BEN-zil BEN-zoe-ate Chemical Class: Benzoic Acid Medically reviewed by Drugs.com. Last updated on Nov 19, 2018. Uses for benzyl benzoate Benzyl benzoate is used to treat lice and scabies infestations. Benzyl benzoate is believed to be absorbed by the lice and mites and to destroy them by acting on their nervous system. Benzyl benzoate is available without a prescription. Before using benzyl benzoate n deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For benzyl benzoate, the following should be considered:

Alle rgies

Tell your doctor if you have ever had any unusual or allergic reaction to benzyl benzoate or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of benzyl benzoate in children with use in other age groups, benzyl benzoate is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of benzyl benzoate in the elderly with use in other age groups. However, older people may have dry skin and the medicine may make the condition worse.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of benzyl benzoate. Make sure you tell your doctor if you have any other medical problems, especially:

Inflammation of the skin (severe)-Use of benzyl benzoate may make the condition worse

Proper use of benzyl benzoate

Benzyl benzoate usually comes with patient directions. Read them carefully before using benzyl benzoate.

Use benzyl benzoate only as directed. Do not use more of it and do not use it more often than recommended on the label. To do so may increase the chance of absorption through the skin and the chance of side effects.

Keep benzyl benzoate away from the eyes and other mucous membranes, such as the inside of the nose, because it may cause irritation . If you accidentally get some in your eyes, flush them thoroughly with water at once.

Do not use benzyl benzoate on open wounds, such as cuts or sores on the skin or scalp. To do so may increase the amount of absorption, which may increase the chance of side effects.

Your sexual partner or partners, especially, and all members of your household may need to be treated also, since the infestation may spread to persons in close contact. If these persons have not been examined for infestation or if you have any questions about this, check with your doctor.

To use benzyl benzoate for lice:

If your hair has any cream, lotion, ointment, or oil-based product on it, shampoo, rinse, and dry your hair and scalp well before applying benzyl benzoate.

Apply enough medicine to thoroughly wet the dry hair and scalp or skin.

Allow the medicine to remain on the affected areas for 24 hours.

Then, thoroughly wash the affected areas with warm water and soap or regular shampoo.

Rinse thoroughly and dry with a clean towel.

After rinsing and drying, use a fine-toothed comb (less than 0.3 mm between the teeth) to remove any remaining nits (eggs) or nit shells from your hair, or, if you have fine hair, you may use a tweezer or your fingernails to pick nits out.

To use benzyl benzoate for scabies:

If your skin has any cream, lotion, ointment, or oil on it, wash, rinse, and dry your skin well before applying benzyl benzoate.

If you take a bath or shower before using benzyl benzoate, dry the skin well before applying the medicine.

Apply enough medicine to cover the entire skin surface from the neck down, including the soles of your feet, and rub in well.

Allow the medicine to remain on the body for 24 hours.

Then, thoroughly wash the body with warm water and soap.

Rinse thoroughly and dry with a clean towel.

Immediately after using benzyl benzoate, wash your hands to remove any medicine that may be on them.

Treatment may need to be repeated for severe infestation.

Dosing

The dose of benzyl benzoate will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of benzyl benzoate. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For topical dosage form (emulsion): For lice infestation: Adults-Use just one time. For severe cases, treatment may be repeated two or three times after twenty-four hours. Children- For infants: Use mixed with three parts of water, just one time. For older children: Use mixed with an equal quantity of water, just one time. For scabies infestation: Adults-Use just one time. For severe cases, treatment may be repeated after twenty-four hours one time anytime within five days. Children- For infants: Use mixed with three parts of water, just one time. For older children: Use mixed with an equal quantity of water, just one time.

Precautions while using benzyl benzoate

To prevent reinfection or spreading of the infection to other people, good health habits are required. These include the following:

For lice infestation:

Disinfecting or washing combs, curlers, and brushes in very hot water (65 °C or 150 °F) for about 10 minutes immediately after using.

Washing in very hot water all recently worn clothing and used bed linens and towels, and drying them in a hot dryer for at least 20 minutes. Articles that cannot be washed may be dry-cleaned, pressed with a hot iron, or just placed in a hot dryer.

Sealing stuffed toys and other non-washable articles in a plastic bag for 2 weeks, or placing these items in the freezer (in sealed plastic bags) for 12 to 24 hours.

Vacuuming all rugs, mattresses, pillows, furniture, and car seats to get rid of fallen hairs with lice.

For scabies infestation: Washing all recently worn clothing such as underwear and pajamas, and used sheets, pillowcases, and towels in very hot water or dry-cleaning.

Benzyl benzoate side effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention sudden loss of consciousness Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Burning or itching of skin Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Benzyl Benzoate Benzyl benzoate is not difficult to find and is the common ingredient in most over-the-counter products marketed to remove or kill house dust mites. From: The Cat, 2012 Related terms: AllergenBenzoic AcidBenzyl AlcoholIvermectinAgaroseAtopyPermethrinScabiesMethanolMite View all Topics Download as PDF alert About this page Learn more about Benzyl Benzoate Etiologic Agents of Infectious Diseases Dirk M. Elston, in Principles and Practice of Pediatric Infectious Diseases (Fourth Edition), 2012

Benzyl benzoate 10% to 25%.

Benzyl benzoate remains one of the most commonly prescribed agents for scabies in many parts of the world and compares favorably with other topical agents and oral ivermectin.17,18 Benzyl benzoate is not available in the U.S. or Canada. The 25% emulsion is applied below the neck, with 3 applications during a 24-hour period. In young adults or children, the concentration can be reduced to 12.5%. Use can be complicated by allergic contact dermatitis, and benzyl benzoate should not be used during pregnancy, or in lactating women, infants, or children <2 years of age because of the risk of neurotoxicity.

Purchase book Ectoparasites (Lice and Scabies) Dirk M. Elston, in Principles and Practice of Pediatric Infectious Diseases (Fifth Edition), 2018

Benzyl Benzoate 10% to 25%.

Benzyl benzoate remains one of the most commonly prescribed agents for scabies in many parts of the world and compares favorably with other topical agents and oral ivermectin. Benzyl benzoate is not available in the US or Canada. The 25% emulsion is applied below the neck, with 3 applications during a 24-hour period. In young adults or children, the concentration can be reduced to 12.5%. Use can be complicated by allergic contact dermatitis, and benzyl benzoate should not be used during pregnancy, in lactating women, in infants, or in children younger than 2 years because of the risk for neurotoxicity.

2.17.16 Anti-scabies

, crotamiton, malathion and permethrin (Section 2.17.13) are available for external treatment of scabies. External treatments with lindane are not recommended and have been removed from the market in many countries. Two studies from India found significantly higher concentrations of lindane in maternal and cord blood from pregnancies with intrauterine growth restriction in comparison to control pregnancies (Sharma 2012, Pathak 2011). Ivermectin – available for example in France – is used orally for scabies (Chapter 2.6).

Apart from irritation of the skin and mucosa, there has not been any indication of appreciable toxicity either in animal experiments or use in humans after external use of benzyl benzoate (Fölster-Holst 2000). In a study in Thailand, 444 pregnant women who had used a 25% benzyl benzoate preparation topically during their pregnancy, showed no increased risk for birth defects. However, treatment was mostly applied in the second and third trimesters (Mytton 2007).

Crotamiton is only absorbed percutaneously to a very limited degree. An accumulation of the substance has, up to now, not been documented. By comparison to other anti-scabies medications it is thought to be less effective (Fölster-Holst 2000). No teratogenic effects have been observed in animal experiments. While studies concerning use during pregnancy are lacking, a substantial risk with topical use is unlikely.

Permethrin is more effective in the treatment of scabies compared to Benzyl benzoate 25%, Crotamiton 10% or Malathion 0.5% lotion. Because in medical treatments the skin is only exposed twice for a short period of time teratogenic effects are not expected.

Purchase book

Antiparasitic drugs

Stephen W Page, in Small Animal Clinical Pharmacology (Second Edition), 2008

Benzyl benzoate

Benzoic acid phenylmethyl ester.

Clinical applications

Benzyl benzoate is used as a pediculicide and scabicide in dogs, although its principal use in humans is as a repellent of ticks, chiggers and mosquitoes. It is generally applied as a spot treatment.

Pharmacokinetics

Benzyl benzoate is rapidly absorbed and is hydrolyzed to benzoic acid and benzyl alcohol, conjugated with glycine or glucuronide and eliminated in urine.

Pharmacology and toxicology

Benzyl benzoate, lindane, and the pyrethroid allethrin are available for external use in treating scabies. Ivermectin is indicated for oral usage. For lice, coconut oil, pyrethrum extract, the pyrethroids allethrin and pyrethrin, and lindane are used. Crotamiton and the pyrithroid permethrin are used for both scabies and lice infestations.

Benzyl benzoate was banned in the USA because its metabolite, benzyl alcohol, was associated with neonatal fatal intoxication (the “gasping syndrome”, with encephalopathy, severe metabolic acidosis, bone marrow depression, and multiple organ failure). However, intoxication occurred only when benzyl alcohol itself was used to rinse central vein catheters. Apart from local skin irritation, there has to date been no substantial toxicity observed after topical application of benzyl benzoate (Fölster-Holst 2000). A prospective study of 113 pregnant women using permethrine shampoo during pregnancy, 31 of them during the first trimester, did not reveal prenatal toxicity (Kennedy 2005, 2003).

Approximately 10% of lindane is absorbed through the skin (see also Chapter 4.12). Lindane is potentially neurotoxic. Animal experience has demonstrated that it is stored in fat tissue and in the testes. Damage of Leydig cells has been observed (Suwalsky 2000). According to European environmental guidelines, its use is not permitted after 2007.

The synthetic pyrethroids, allethrin, permethrin, and pyrethrin, have longer half-lives than the “natural” pyrethrum. About 2% of permethrin is absorbed after topical application (Fölster-Holst 2000).

Less than 1% of crotamiton is absorbed after dermal application.

No teratogenic effects have been observed with any of the substances mentioned after normal usage.

Recommendation.

Scabies should be treated with benzyl benzoate or crotamiton, and lice infestation with coconut oil or pyrethrum extract. Synthetic pyrethroids are the drugs of second choice during pregnancy. Lindane should be avoided; however, if there has been acute topical treatment, no action need be taken.

Read full chapter

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Sarcoptes scabiei and Scabies

Ian Burgess, in Advances in Parasitology, 1994

7.1.2 Benzyl Benzoate

Benzyl benzoate was first used in the form of “balsam of Peru”, of which it forms the active constituent and which is still used in some countries with the attendant risk of contact irritancy (Temesvart et al., 1978). The first real trials of benzyl benzoate itself were performed by Kissmeyer (1937), but its use was largely established by the trials conducted by Mellanby and co-workers (Mellanby et al., 1942a; Mellanby, 1972, 1973). At therapeutic concentrations it is a skin irritant and may cause severe stinging, especially of excoriated skin, and consequently was soon not recommended for use on children (Bradshaw, 1944). Dilution to make it more acceptable seriously reduces its efficacy, as does incomplete application or not making the generally accepted two or three applications (Alexander, 1984; Bums, 1991). In contrast, Mellanby et al. (1942a) obtained nearly 100% effectiveness with a single application. This treatment has made a brief come-back in some parts of eastern Europe and countries of the former Soviet Union in recent years (Levkov, 1980; Fedorovskaia et al., 1986) as part of more concentrated efforts to control the disease.

Treatment

Treatment of scabies is with topical permethrin, benzyl benzoate, malathion or oral ivermectin. The patient should apply 5% permethrin cream to the whole body, including the scalp, all folds, groin, navel, external genitalia and skin under the nails, washing it off after 12?hours. In adults with classical scabies, treatment of the face is controversial, but in babies the skin of the face should also be treated. A second application 7 days after the original treatment must be prescribed and all the affected members of a household require treatment at the same time to prevent cyclical reinfestations. Oral ivermectin is being increasingly used as a first-line treatment. Severe outbreaks require a second dose of ivermectin at a 2-week interval (200?µg/kg body weight). Treatment of secondary bacterial infection and antihistamines may be required. Washing clothes and linen at 60° will kill all the young fecundated female mites (an alternative is to keep these in a plastic bag for 48-72?hours, as mites separated from the human host die within this time). It is important to explain that pruritus commonly lasts for several weeks after cure, which may be partially alleviated by non-sedating or sedating antihistamines.30

Systemic effects

Acute toxicity: No information found for benzoin. Benzyl alcohol and benzyl benzoate possess low acute toxicity (see Constituent profiles, Chapter 14).

Carcinogenic/anticarcinogenic potential: Gum benzoin was mutagenic in a mouse lymphoma assay (MLA), but not in Chinese hamster ovary cells (Oberly et al 1993). Gum benzoin produced CA in Chinese hamster lung (CHL) cells (Ishidate et al 1988), but was not genotoxic in a mouse micronucleus test (Shelby et al 1993) or in the S. typhimurium TA135/pSK1002 umu test (Nakamura et al 1987). It was not carcinogenic when fed to male rats at 125 or 250 ppm, to female rats at 250 or 500 ppm, and to male and female mice at 2,500 or 5,000 ppm for 104 weeks (National Toxicology Program 1980). The resinoid contains no known carcinogens, and the MLA and CHL results are false positives (Kirkland et al 2005).

Oral ivermectin: 200 µg?/?kg dose; dosage as in Table 29-2

Plus supervised topical scabicide such as permethrin or benzyl benzoate 2-3 times in the first week, then weekly until cured

Plus keratolytic therapy with lactic acid?/?urea cream or salicylic acid cream initially daily (except when applying topical scabicide), until crusts are resolved

Isolate the patient to prevent scabies transmission to staff and family – use long-sleeved gowns, gloves, foot covers, and a single room where possible

4.12.6 Medications for lice and scabies

For topical treatment of pediculosis (lice infestation), dimeticone, coconut oil, pyrethrum, permethrin, malathion and allethrin I are used. For topical treatment of scabies, , crotamiton and permethrin are available. Scabies may be treated systemically with ivermectin which is not licensed for this indication in all countries (Chapter 4.4). Topical medications containing lindane have been removed from the market in many countries.

Knowledge about the passage of medications for parasites into the mother’s milk is scarce and is practically only available for the now obsolete lindane, an insecticide which is widespread in the environment. Our environment is widely contaminated with lindane; it can be detected in the mother’s milk due to contaminated food, without therapeutic usage (Chapter 4.18). Studies with a 0.25% lindane solution showed dermal absorption of barely 10%. In one case, after a 3-day scabies treatment, 0.9 mg/kg (ppm) lindane was measured in the milk fat (1 liter of milk has, on average, 30-35 g of milk fat). After another one-time application it was 2.0 mg/kg. Compared to the average environmental contamination load of mother’s milk, this was more than a 60-fold increase (Senger 1989). Lindane is neurotoxic; cerebral seizures after repeated topical applications in children are reported (Daud 2010). However, nothing is published on clinical effects after exposure through the mother’s milk.

For the rest of the above-mentioned substances, no toxic effects by exposure via the mother’s milk are expected. Pyrethrum has a shorter half-life than the synthetic pyrethroids. In the USA, permethrin is approved from the age of 3 months. The experience to date on therapeutic use in infants does not indicate any appreciable side-effects after breast feeding (Fölster-Holst 2000).

Recommendation

Lice infestation should be treated with dimeticone during breastfeeding. The medication of choice for scabies during breastfeeding is permethrin.

BENZYL BENZOATE, lotion

– Apply the lotion to the whole body, including scalp, postauricular areas, palms and soles. Pay particular attention to skin creases and interdigital web spaces. Do not apply to the face and mucous membranes.

– In children under 2 years: apply only once; wrap hands to avoid accidental ingestion; rinse off when the recommended contact time has elapsed.

– In children ? 2 years and adults: a second application (e.g. after 24 hours, with a rinse between the two applications; or two successive applications, 10 minutes apart, when the first application has dried, with a rinse after 24 hours) reduces the risk of treatment failure.

Contra-indications, adverse effects, precautions

– Do not apply to broken or infected skin. In the event of secondary bacterial infection, administer an appropriate local (antiseptic) and/or systemic (antibiotic) treatment 24 to 48 hours before applying benzyl benzoate.

– May cause: burning sensation; contact dermatitis in case of repeated applications; seizures in the event of marked transcutaneous absorption (broken skin, children < 2 years).

– Avoid contact with eyes. In case of eye contact, flush immediately with plenty of water.

– DO NOT SWALLOW (risk of seizures). In case of ingestion: do not induce vomiting, do not perform gastric lavage; administer activated charcoal.

– Pregnancy: no contra-indication. Do not leave on skin longer than 12 hours; do not repeat application.

– Breast-feeding: no contra-indication. Do not apply to the breasts.

Remarks

– Close contacts should be treated at the same time regardless of whether they have symptoms or not. Decontaminate clothes and bed linen of patients and close contacts simultaneously.

– Itching may persist for 1 to 3 weeks despite successful treatment. Do not re-treat during this period. The treatment may be repeated if specific scabies lesions (scabious burrows) are still present after 3 weeks.

– 5% permethrin cream or lotion is preferred when available, especially in children less than 2 years and pregnant or lactating women.

– Storage: below 25 °C –

Overview(active tab)

Safety

Resources

What Is It?

Benzyl Alcohol is an organic alcohol found in many fruits and teas. Benzyl Alcohol has a hydroxyl group (-OH), while the related compound, Benzoic Acid has a carboxyl group (-COOH). Sodium Benzoate, Calcium Benzoate and Potassium Benzoate are salts of Benzoic Acid. Benzyl Benzoate is an ester of Benzyl Alcohol and Benzoic Acid. Benzyl Alcohol, Benzoic Acid and its salts, and Benzyl Benzoate are used in a wide variety of cosmetics and personal care products, including baby products, bath products, soaps and detergents, eye makeup, blushers, cleansing products, make up products, as well as hair, nail and skin care products. Why is it used in cosmetics and personal care products? The following functions have been reported for these ingredients. Corrosion inhibitor – Sodium Benzoate ragrance ingredient – Benzyl Alcohol, Benzoic Acid, Sodium Benzoate, Benzyl Benzoate pH adjuster – Benzoic Acid Preservative – Benzyl Alcohol, Benzoic Acid, Sodium Benzoate, Calcium Benzoate, Potassium Benzoate Solvent – Benzyl Alcohol, Benzyl Benzoate Viscosity decreasing agent – Benzyl Alcohol Follow this link for more information about how preservatives protect cosmetics and personal care products.

Scientific Facts: Benzyl Alcohol and Benzoic Acid are found naturally in many foods such as apricots, snap beans, cocoa, cranberries, mushrooms and honey. Benzyl Alcohol is also found in the essential oil of many plants, including jasmine, hyacinth and ylang-ylang. Benzyl benzoate Download Zoom

Benzyl benzoate Ph Eur,BP,USP. CAS No. 120-51-4, EC Number 204-402-9.

Benzyl benzoate: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikas (COA) ve Kalite Uygunluk Sertifikas (COQ), dosyalar, broürler ve dier dokümanlar.

Contact Customer Service stainl. st. 25 l Upon Order Completion More Information – Add To Favorites Add To Cart Description Number 101806 Synonyms Benzoic acid benzyl ester Product Information CAS number 120-51-4 EC index number 607-085-00-9 EC number 204-402-9 Grade Ph Eur,BP,USP Hill Formula C04H0²O² Chemical formula C6H5COOCH²C6H5 Molar Mass 212.24 g/mol HS Code 2916 31 00 Structure formula Image Structure formula Image Applications Application Benzyl benzoate Ph Eur,BP,USP. CAS No. 120-51-4, EC Number 204-402-9. Physicochemical Information Boiling point 324 °C (1013 hPa) Density 1.12 g/cm3 (20 °C) Flash point 158 °C Ignition temperature 480 °C Melting Point 21 °C Vapor pressure <0.1 hPa (25 °C) Solubility 0.0153 g/l Toxicological Information LD 50 oral LD50 Rat 1904 mg/kg LD 50 dermal LD50 Rabbit 4000 mg/kg Safety Information according to GHS Hazard Pictogram(s) Hazard Pictogram(s) Hazard Pictogram(s) Hazard Statement(s) H302: Harmful if swallowed. xcluded by production process Sulfated ash ? 0.05 % Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).

Corresponds to Ph Eur, BP, USP Benzyl benzoate otion, 25%

General information

Benzyl benzoate is a synthetic compound that is produced from benzoic acid and benzyl alcohol. It is toxic to the ectoparasites Sarcoptes scabiei hominis, Pediculus humanus capitis, P. humanus corporis and Pthirus pubis.

Clinical information

Uses

Treatment of scabies and pediculosis of the head, body and pubic area.

Dosage and administration

All doses are suitable for adults and children.

Scabies:

The lotion should be applied to all skin surfaces, from the scalp to the soles of the feet. Care should be taken to avoid contact with the eyes. It is not necessary to bathe before application. To prevent reinfestation, clothing and bedding should be washed or left outside exposed to the air for 72 hours. The lotion is usually applied once daily at night on 2 consecutive days. This may be followed by a single application at night 3 days later.

All members of the household should be treated simultaneously.

Pediculosis:

The lotion should be applied to the affected area and left for 24 hours before being rinsed off. If necessary, treatment may be repeated after 7 and 14 days.

Contacts should also be treated at the some time.

Contraindications

Known hypersensitivity to benzyl benzoate.

Precautions

Benzyl benzoate should not be applied to acutely inflamed or broken skin.

Use in pregnancy

Benzyl benzoate may be applied safely during pregnancy.. Fabrika dorudan sat 2. Yüksek kalite 3. Rekabetçi fiyat 4. En erken teslimat 5. 24 saat çevrimiçi hizmet Benzil benzoat% 99 +; Benzoik asit benzil ester; Ascabin; Ascabiol; Benylate; Benzil alkol benzoik ester; BENZOATO DE BENCILO; Benzoik asit fenilmetil ester; Benzil benzen karboksilat; Benzil fenilformat; Fenilmetil benzoat; Scabagen; Vanzoate Kullanm: Benzil benzoat esas olarak tekstil yardmc maddesi, parfüm ve lezzet, eczane, plastikletirici vb. Alanlarnda kullanlmaktadr. SSS 1. Hangi ödeme koullar sizin için kabul edilebilir mi? T / T veya L / C. 2. Teslimat süreniz nedir? Genellikle sevkyat 10-15 gün içinde düzenleriz. 3. Paketlemeye ne dersiniz? Müterinin isteine göre yapabiliriz. 4. Soruturmam için ne zaman fiyat teklifi alabilirim? Genellikle 24 saat içinde! 5. Ürünlerin geçerlilii nedir? Üreticinin beyanna göre. 6. Hangi belgeleri salyorsunuz? Genellikle, Ticari Fatura, Paket Listesi, Yükleme Listesi, COA, Salk Sertifikas ve Menei Sertifikas salarz. Piyasalarnzn özel gereksinimleri varsa, lütfen bize bildirin. 7. Yükleme limannz nerede? Genellikle Qingdao, Çin. Ayrca Tianjing, anghay ve benzeri. Neden Biet’i seçmelisin? 1. Aktif ilaç bileenleri ürünlerinde 7 yllk bir tecrübeye sahibiz. Profesyonelimiz ve düünceli sat sonras servis endielerinizi ortadan kaldrr. 2.Bize farkl seviyelerde binlerce ürün salayabiliriz. 3. Uygun bir istasyon satn alma hizmeti sunuyoruz.

99% üzerinde Güvenli Benzil Benzoat Kullanm Hekimlii Hammaddesi CAS # 120-51-4 laç Endüstrisinde Kullanlan Benzil Benzoat’n Orijinal Kayna 99.0dakika Farmakodinamik: Benzil benzoat, uyuz tedavisinde kullanlan eski preparatlardan biridir. Uyuzlar, akar sarcoptes tarann neden olduu deri enfeksiyonudur. Ar kant (özellikle gece), krmz lekeler ve sekonder bir enfeksiyona neden olabilir. Benzil benzoat bu akar için öldürücüdür ve bu nedenle uyuz tedavisinde faydaldr. Ayn zamanda, ba ve vücudun bit bitiini tedavi etmek için kullanlr. Benzil benzoat, irritatif özelliklerinden dolay uyuz için tercih edilen tedavi deildir. Ürün Detaylar: CAS # 120-51-4 EINECS # 204-402-9 Uygulamalar Benzoatlar Formül Ci4H12O2 Kategoriler Lezzet & Koku, Organik Ara ürünler, Kiisel Bakm ve Kozmetik, laç ve nce Kimyasallar, Tekstil Yardmclar Biti ve deri durum uyuzlarndan sorumlu olan akarlar öldürmek için kullanlr. Aksiyon modu: Benzil benzoat, parazitin sinir sistemi üzerinde toksik etkiler yaratarak ölümüne neden olur. Ayn zamanda, kesin etki mekanizmas bilinmemekle birlikte, akar yumurta için toksiktir. In vitro, benzil benzoat’n Sarcoptes akarn 5 dakika içinde öldürdüü tespit edildi. Metabolizma: Benzoik asit ve benzil alkol ile hzla hidroliz edilir ve benzoik asite kadar daha da oksitlenir. Benzoik asit hippurik asit oluturmak üzere glisin ile konjuge edilir.Sekonder enfeksiyon varsa topikal ve sistemik antibiyotik verilmelidir.

Yaknmalar olsun olmasn ailedeki tüm bireyler ayn anda tedaviye alnmaldrlar. Tedavisi çok zor olmasa da uratrcdr ve titiz bir uygulama gerektirir. Hastalk bir aile enfeksiyonu olduundan, ailedeki dier fertlerin de ayn ekilde tedaviye alnmas gerekmektedir. Tüm giysiler, iç çamar, nevresim ve yatak çaraflar çamar makinasnda 50 C kaynatlarak ykanr, kaynatlamayan eyalar çamar kurutucularda ayn sda 20 dakika kurutulur, kzgn ütüyle ütülenebilir. Bunlar yapamayacamz tüm bireysel malzemeler bir hafta insandan uzak kalacak ekilde, metal veya plastik bir kapta saklanarak; insan dnda uzun süre yaayamayan böceklerin ölmesi salanr. Bir dier alternatif metod ise derin dondurucuda -20 C de 12 saat bekletilmesidir.

Ev eyalarnn silinmesi yeterlidir. Dezenfektan kullanmna gerek yoktur ve evde ilaçlama yaplmas gerekmemektedir. Tedavi sonrasnda; kullanlan ilacn irritasyonuna veya ölü parazitin kalntlarnn yol açt hipersensitiviteye bal olarak, kant bir kaç gün daha devam etmektedir. Bu unutulmamaldr. kantnn devam etmesi hastaln devam ettii anlamna gelmemelidir. Tedavide kullanlan çeitli ilaçlar vardr. Permethrin %1 ve 5 krem, losyon ve ampuan (Zalvor, Kwellada, Nix): Toksisitesi az, sarkopta etkisi güçlüdür. laç, akam bir dutan sonra ba hariç bütün vücuda kanmayan yerler dahil uygulanr, çkarlan giysiler tekrar giyilir, 7-8 saat sonra yeniden du alnr. Yeni giysiler giyilir. Çamar ve eya dezenfeksiyonu yaplr. ki aylktan küçük bebeklerde ve gebelerde kullanlmamaldr. Piretrin %1 losyon ve ampuan (Kwell-P): Krizantem bitkisinin yaprandan elde edilen doal ilaçlardr. Permetrin gibi uygulanr. Benzil benzoat %12.5 ve 25 losyon ve ampuan (Scabin, Benzogale): Permetrin gibi uygulanr. Gama benzen heksaklorid %1 sol. (Kwell): Nörotoksik etkilerinden dolay Türkiye’de kullanmdan kalkm olup yurtdnda halen kullanlmaktadr. Kükürtlü merhem (Vazelin içerisinde %6-12’lik hazrlatlr veya Pomad Wilkinson): Toksisitesi olmadndan bebeklerde ve gebelerde tercih edilir. Kokusu ve kirlilii istenmeyen tarafdr. Kese yapldktan sonra ovalanarak banyo yaplmadan 3 gece üstüste uygulanr. Dördünce gece banyo yaplr, eyalar dezenfekte edilir. Crotamiton krem (Eurax): Etkisi çok güçlü deil, toksisitesi az. Türkiye’de preparat yoktur. Ivermectin: 200 mikrogram/kg tek doz olarak verilmekte ve 2 hafta sonra ayn doz tekrarlanmaktadr. Lindane : % 1 lik formu tüm vücuda uygulanr ve 8 saat sonra ykanr. Ancak sistemik toksit etkileri nedeni ile tercih edilmemelidir. Gebe ve emziren kadnlarda ve 2 yan altndaki çocuklarda kullanlmamaldr. Nörotoksik ve aplastik anemi yapmas ile ilgili klinik sunumlar bulunmaktadr. lk tedaviden sonra 15 gün kadar kant azalarak devam edebilir. Gereinde 1-2 hafta sonra ayn tedavi tekrarlanabilir. lave olarak antihistaminikler, topikal kortikosteroidler ve sekonder infeksiyon varsa antibiotikler verilebilir.

BENZL BENZOAT TOKSSTESNN N VVO KOULLARDA ANATOMK, FZYOLOJK, STOGENETK VE BYOKMYASAL PARAMETRELERLE ARATIRILMASI

Thesis · June 2018 with 41 Reads Thesis for: PhD, Advisor: Zafer TÜRKMEN Cite this publication Ali Acar Abstract

Bu çalmada, gda, kozmetik, tarm ve ilaç sektörlerinde geni kullanm alanna sahip olan Benzil benzoat’n toksik etkileri Allium cepa L. test materyali kullanlarak aratrlmtr. Toksisitenin belirlenmesinde fizyolojik parametreler; kök uzunluu, arlk art ve çimlenme yüzdesinin belirlenmesi ile, sitogenetik deiimler; kromozomal anormalliklerin oluumu, mikronükleus (MN) skl ve mitotik indeks orannn (MI)’in belirlenmesi ile, anatomik deiimler; kök ucu hücrelerinde meydana gelen anatomik deiimlerin belirlenmesi ile, biyokimyasal deiimler; lipid peroksidasyon tayini ve antioksidan enzim analizi ile tespit edilerek, elde edilen veriler istatistiksel olarak deerlendirilmitir. Bulblar bir (1) kontrol ve üç (3) uygulama grubu olmak üzere toplam dört (4) gruba ayrlm, kontrol grubu bulblarna çeme suyu, uygulama gruplarndaki bulblara ise 10.000, 25.000 ve 50.000 mg/L dozunda Benzil benzoat ile 72 saat süresince muamele edilmitir. Uygulama sonunda kontrol grubuyla kyaslandnda, uygulama gruplarnda doza bal olarak çimlenme yüzdesi, arlk kazanm, kök uzunluu ve MI’in azald, kromozomal anormallikler, MN oluumu, MDA, SOD ve CAT düzeylerinin ise artt tespit edilmitir. Uygulamaya bal olarak kök ucu hücrelerinde fragment, yapkan kromozom, kromozom köprüsü, kromatinin eit olmayan dalm ve c-mitoz eklinde kromozomal anormallikler meydana geldii belirlenmitir. Ayrca kontrol grubuyla karlatrldnda Benzil benzoat uygulamasnn kök ucu hücrelerinde anatomik deiikliklere neden olduu belirlenmitir. Bu deiikliklerin nekroz, hücre deformasyonu, yasslam hücre çekirdei, korteks hücre deformasyonu, korteks hücrelerinde baz maddelerin birikimi, korteks hücre çeper kalnlamas ve belirgin olmayan iletim doku eklinde olduu belirlenmitir. Sonuç olarak, Benzil benzoat’n A. cepa kök ucu hücrelerinde doza bal toksik etki gösterdii fizyolojik, anatomik, sitogenetik ve biyokimyasal parametreler ile tespit edilmitir. Ayrca, çalmada kullanlan parametrelerin toksisitenin belirlenmesinde kullanl biyobelirteçler olduu tespit edilmitir.

Benzil benzoat nereden biliyorsun? TNJ kimyasal anahtar Benzil benzoat fabrika ve Çin’den terdarikçilerin olduunu lütfen unutmaynz. % 99.9 teknik notu/pharma snf Benzil benzoat salayabilirsiniz. Daha fazla bilgi edinmek istiyorsanz lütfen sales22@tnjchem.com Benzil benzoat CAS 120-51-4 bir renksiz veya soluk sar yapkan effaf sv. 17 santigrat derece veya daha düük scaklk koullarnda, beyaza kat katlam. Benzil benzoat yüksek saflkta, hafif koku vardr. Benzil benzoat suda çözünmez ama organik çözücüler içinde çözünür. Benzil benzoat hightemperature solvent, misk tek çözücü. Benzil benzoat eczane ve parfüm endüstrisi uygulamalar nedeniyle düük volatilization ve göreli istikrar sadece kendi karakterleri vardr. belirtimi madde BP2000 parfümeri snf görünüm sar effaf sv renksiz effaf sv koku … hafif kokusu çiçek saflk, % ≥99.0 ≥99.90 asit (ml, 0.1N 2.0 g NaOH) ≤0.2 ≤0.2 belirli Gravity20℃ , kg / m3 1118 – 1122 1118 – 1122 refraktif Index(nD20) 1.568 – 1.570 1.568 – 1.570 donma noktas (℃) ≥17.0 ≥17.0 nem (%) ≤0.3 ≤0.2 sülfat kül (%) ≤0.1 ≤0.2 uygulama 1) Benzil benzoat Tekstil yardmc, koku ve lezzet, eczane, Plastifiyan alannda kullanlan balca vb 2) plastisite, solvent, güvenlii ve çevre koruma, iyi bir performans için Benzil benzoat yaygn ba Ajan, seviyelendirme Ajan, onarm arac sentezi kullanlmtr vb ambalaj demir davul bana 225 kg , bana 20” kapsayc; 80drum 25kg/plastik davul. depolama depolanan bir serin ve iyi havalandrlm ambar içinde.

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BENZYL BENZOATE (BENZL BENZOAT)

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