CAPRYLIC/CAPRIC TRIGLYCERIDE

CAPRYLIC/CAPRIC TRIGLYCERIDE = MCT – MEDIUM CHAIN TRIGLYCERIDE (CAPRYLIC / CAPRIC TRIGLYCERIDE)

Caprylic/Capric Triglyceride – also known as MCT Oil – is a classic emollient derived from renewable natural raw materials.

It is produced from vegetable Glycerine and fractionated vegetable Fatty Acids, mainly Caprylic and Capric Acids.

MCT Oil is a clear and colourless liquid, neutral in odour and taste.

It is fully saturated and therefore highly resistant to oxidation

MCT (Medium Chain Triglyceride)Chemical Name: Octanoic/Decanoic Acid Triglyceride

Caprylic/Capric Triglyceride, alternatively known as Octanoic/Decanoic Acid Triglyceride or MCT Coconut Oil, is a specialized esterification of coconut oil extracted from the kernel of matured coconuts.

This oil uses only the medium chain triglycerides, namely Caprylic Acid and Capric Fatty Acid, contained in raw coconut oil.

The result is an ideal carrier oil that can be used in a variety of applications.Caprylic/Capric Triglyceride is silky and light to the touch, absorbing into the skin easily.

This means when it’s used in cosmetic and skincare products, organic MCT oil leaves no greasy feeling on the skin.

With a long shelf life, low color, minimal odor and low to no hazard, this carrier oil is an ideal selection for sensitive skin and oil free products.

Caprylic/Capric Triglyceride

Inci name: Caprylic/Capric triglyceride

French name: Caprylic/Capric Triglyceride

CAS number: 73398-61-5 / 65381-09-1

EC number: 277-452-2 / 265-724-3

Other appellations

Caprylic/capric triglycerides are a mix of tri-esters with carbon chains of C8 and C10 derived from coconut oil and glycerin. Caprylic/capric triglycerides are classed as medium chain triglycerides and used in the beauty industry as an emollient, dispersing agent and solvent.

Benefits of Caprylic/Capric Triglycerides:

Caprylic/capric triglycerides are a great antioxidant emollient as they provide an occlusive film around the epidermis to prevent loss of moisture/water from the skin, keeping it hydrated and supple. Being a lightweight and non-greasy barrier of lubrication, they are easily diffused on to and absorbed by the skin. As a dispersing agent, they enhance the delivery of vitamins, pigments and other active ingredients contained in the product. Caprylic/capric triglycerides also provide great stability to the product and resistance to premature aging processes like oxidation and can function as a biodegradable antimicrobial, antifungal, and antiviral agent.

Caprylic/capric triglyceride is a valid substitute of vegetable oils in that, being fully saturated, it resists oxidation. Its low molecular weight lends it a silky feel. Thanks to its emollient properties, it is able to form a lipid film that limits the loss of moisture from the outermost layer of your skin.

Caprylic/Capric Triglyceride is a compound formed as a result of combining fatty acids derived from natural oils, such as coconut oil, with glycerin. It is typically used as an ingredient for skin care products, like soaps and cosmetics, because it works as an antioxidant and helps to make skin smooth. It is a clear, colorless and odorless liquid and a natural substitute for the synthetic chemicals found in the many skin products. Thus, it can be found in the products like moisturizing face creams, anti-aging serums, sunscreens, lipstick, eye liner, lip balm, perfumes and several other products. Apart from the personal care, they can also be used in food & beverages, pharmaceutical, and other industries.

Side Effects & Toxicity:

An extremely safe ingredient, caprylic/capric triglycerides have low toxicity in general use and is shown to be non-irritating and suitable for sensitive skin.

Caprylic/Capric Triglyceride is a raw material for Cosmetic formulations which provides emolliency. It helps the skin resist tp prevent moisture loss

Caprylic Capric Triglyceride also be used to thicken a formula or enhance the penetration of key ingredients.It is known to improve to the spreadability of a product

Caprylic Capric Triglyceride is derived from coconut oil and glycerin. It is Clear, non-viscous liquid

Caprylic/capric triglyceride is derived from coconut oil and glycerin and is considered an excellent emollient and skin-replenishing ingredient. Of note, its mix of fatty acids replenish skin’s surface and help it to resist moisture loss.

Caprylic/capric triglyceride can also function as a thickener or penetration enhancer, but its chief job is to moisturize and replenish skin. This ingredient’s value for skin is made greater by the fact that it’s considered gentle.

As a raw material caprylic/capric triglyceride is clear, non-viscous liquid.

It is known to improve to the spreadability of formula.

Safety assessments have deemed capric/caprylic triglyceride safe in cosmetic formulations in concentrations below 50%, with reported uses varying between 0.1% to 35%.

CAPRYLIC/CAPRIC TRIGLYCERIDE

Caprylic / capric triglyceride is an oily liquid made from palm kernel or coconut oil.

It is a mixed ester composed of caprylic and capric fatty acids attached to a glycerin backbone. Caprylic/capric triglycerides are sometimes erroneously referred to as fractionated coconut oil, which is similar in composition but typically refers to coconut oil that has had its longer chain triglycerides removed.

Chemically speaking, fats and oils are made up mostly of triglycerides whose fatty acids are chains ranging from 6–12 carbon atoms, in this case the ester is comprised of capric (10 carbon atoms) and caprylic (8 carbon atoms).

Caprylic/Capric Triglyceride is an emollient that is a clear liquid with a mild odor and is insoluble in water. It can be used in applications such as acne treatment, antiperspirant/deodorant, color cosmetics, hair care, skin care, sun car and wipes.

Medium-chain Triglycerides (MCTs) are medium-chain (6 to 12 carbons) fatty-acid esters of glycerol most frequently used in nutraceutical foods and beverages and cosmeceutical personal care products.

In the human body, MCTs passively diffuse from the GI tract into the portal vein without requirement for modification that long-chain fatty acids or very-long-chain fatty acids require.

Since MCTs are bland compared to other fats and do not generate flavor or fragrance off-notes, they are also used in personal care products and pharmaceuticals.

In foods, beverages and nutraceutical applications, MCT ingredients rapidly absorb into the body and are a potentially good energy sources for everyday exercise enthusiasts as well as athletes and bodybuilders.

MCTs are often incorporated into beverages, mixes, nutritional bars or energy foods.

Medium-chain triglycerides are also used as high quality carriers and emollients in the formulation of cosmetics to be certified according to the Natural and Organic Ecocert Standards.

MCTs are frequently found in topical aerosols, foams, creams, ointments and lotions, and are regularly used in flavorings and fragrances because of their bland taste profiles and low natural odor.

Caprylic/capric triglyceride creates a barrier on the skin’s surface, which helps to reduce skin dryness by decreasing the loss of moisture. Its oily texture helps to thicken and provides a slipperiness, which helps make our lotions and natural strength deodorants easy to apply and leaves a non-greasy after-touch

Caprylic/capric triglycerides are naturally occurring in coconut and palm kernel oils at lower levels but to make this pure ingredient, the oils are split and the specific fatty acid (capric acid and caprylic acid are isolated and recombined with the glycerin backbone to form the pure capric/caprylic triglyceride which is then further purified (bleached and deodorized) using clay, heat and steam. No other additives or processing aids are used.

Obtaining: Derived from Coconut Oil and Glycerin, it is considered an excellent emollient and skin repair agent.

It is a mixture of fatty acids.

Benefits: Caprylic/capric triglycerides repair the surface of the skin and resists moisture loss.

It also functions as a thickener, but its main job is to moisturise. They are neutral oils that do not irritate the skin, are easy to apply and are absorbed very quickly.

Major applications of caprylic/capric triglycerides are personal care, food & beverages, pharmaceuticals, and industrial & others.

Food & beverages industry is the largest consumers of caprylic/capric triglycerides.

The personal care application, owing to its significantly growing consumption, and wide range of products such as skin care, body care, baby care, hair care, moisturizers and others are driving the growth of the application industry.

Caprylic/Capric Triglycerides is one of the most preferred triester due to its inherent properties such as safe and highly absorbed ingredient.

Caprylic/Capric Triglycerides, due to its less toxicity, longer shelf life, and creating lubrication barrier for cosmetics product, widely preferred as an ingredient in food & beverages, and personal care products.

CAPRYLIC/CAPRIC TRIGLYCERIDE is derived from coconut oil and glycerin.

CAPRYLIC/CAPRIC TRIGLYCERIDE is a clear, non-viscous liquid.

CAPRYLIC/CAPRIC TRIGLYCERIDE contains a mix of fatty acids that helps to replenish the skin and resist moisture loss.

CAPRYLIC/CAPRIC TRIGLYCERIDE acts as an excellent emollient, dispersing agent and skin-replenishing ingredient.

CAPRYLIC/CAPRIC TRIGLYCERIDE is especially suited to sensitive and oily skin.

CAPRYLIC/CAPRIC TRIGLYCERIDE is used in all skin care creams and lotions, make up, shampoos and cleansers.

CAPRYLIC/CAPRIC TRIGLYCERIDE is classified as :

Emollient

Masking

Skin conditioning

Solvent

Perfuming

CAS Number: 73398-61-5 / 65381-09-1

EINECS/ELINCS No: 277-452-2 / 265-724-3

Chem/IUPAC Name: Decanoic acid, ester with 1,2,3-propanetriol octanoate; Glycerides, mixed decanoyl and octanoyl

Functions:

Dispersing agent

Emollient Moisturiser

Oil Substitute

Solubiliser

Solvent

Spreading Agent

Viscosity Modifier

Caprylic triglyceride, or capric triglyceride, is a compound that combines fatty acids from natural oils, such as coconut oil, with glycerin.

Soaps and cosmetics sometimes include caprylic triglyceride as an ingredient

Caprylic triglyceride is an ingredient used in soaps and cosmetics.

It’s usually made from combining coconut oil with glycerin.

This ingredient is sometimes called capric triglyceride.

It’s also sometimes mistakenly called fractionated coconut oil.

Caprylic triglyceride has been widely used for more than 50 years.

It helps smooth skin and works as an antioxidant.

It also binds other ingredients together, and can work as a preservative of sorts to make the active ingredients in cosmetics last longer.

Caprylic triglyceride is valued as a more natural alternative to other synthetic chemicals found in topical skin products.

Companies that claim that their products are “all natural” or “organic” often contain caprylic triglyceride.

Caprylic triglycerides are compounds made of naturally occurring fatty acids. They’re a clear liquid and slightly sweet to the taste.

The high fat content in triglycerides, along with their texture and antioxidant qualities, make them of particular use for soap and skin care products.

Emollient

Emollients are ingredients that soften your skin. Emollients work by trapping moisture in your skin and forming a protective layer so the moisture can’t escape.

Caprylic triglyceride is an effective skin-softening ingredient.

Dispersing agent

Dispersing agents are the parts of any chemical or organic compound that hold the ingredients together and stabilize them.

Mixing other active ingredients, pigments, or scents in a good dispersing agent keeps the ingredients from clumping together or sinking to the bottom of the mixture.

The waxy and thick consistency of caprylic triglycerides make them an excellent dispersing agent.

Solvent

Solvents are ingredients that can dissolve, or break apart, certain ingredients or compounds.

Ingredients are solvents based on how their molecules are structured and shaped, and how they interact with other substances.

Caprylic triglyceride can dissolve compounds that are designed to clump together. While some solvents have toxic ingredients, caprylic triglyceride doesn’t carry those risks.

Antioxidant

Antioxidants work to neutralize toxins you’re exposed to every day in your environment.

Antioxidants stop the chain reaction called oxidation, which can age your skin and take a toll on your body.

Caprylic triglyceride is full of antioxidants that help preserve your skin and help you feel younger.

Caprylic/capric triglyceride uses

Caprylic triglyceride can be found in topical skin care products that you use on and around your face. It’s used to:

boost the shelf life of these products

add a sheen to your skin that’s light and non-greasy

boost the antioxidants in the product

These products include:

moisturizing face creams

anti-aging serums

sunscreens

eye creams

Caprylic/capric triglyceride in cosmetics

Caprylic triglyceride is a popular ingredient in makeup and other cosmetics. The ingredient keeps pigments evenly distributed in a cosmetic formula without causing a sticky feeling on your skin. You’ll often see this ingredient listed in these cosmetics:

lipstick

lip balm

lip liner

cream-based and liquid foundations

eye liner

Applications of Caprylic/capric triglyceride

Skin Care

Facial Creams & Masks

Body Lotions & Oils

Nail Care

Hand & Foot Care

Oils

Massage

Bath & Shower

Shaving

Sun Care

Sunscreens

After Sun

Self-Tanning

Colour Cosmetics

Eyeshadow

Blush Powder

Primers

Lipsticks

Make-up-remover

Lip Care

Balms

Creams

Sticks

Baby Care

Creams

Lotions

Cleansing

Wet Wipes

Men’ Grooming

Shaving Creams & Oils

After Shave Oils & Lotions

Beard Oils & Balms

Aerosols

Antiperspirants

Deodorants

Perfumes

Hair Care

Oils

Masks

Caprylic/Capric Triglycerides also known as MCT Oil or Medium Chain Triglycerides is gaining widespread attention in beauty, cosmetics, and personal use industries due to its oxidative stability and smooth texture. Caprylic/Capric Triglycerides is produced by reacting coconut oil with glycerol through esterification.

MCT Oil is not oil; it is an ester which primarily contains the Caprylic and Capric medium chain triglycerides present in the coconut oil.

Caprylic/Capric Triglycerides is a clear, colorless and virtually odorless liquid that dispenses quickly at room temperature as compared to its raw material coconut oil which is solid at room temperature. Caprylic/Capric Triglycerides are commonly used in cosmetics as it absorbs rapidly into the skin and adds a smooth and dry oil feel to the skin. It is often used as an ingredient in cream, lotion, moisturizer, cleanser & face wash, serum, and others.

Caprylic/Capric Triglycerides developed around fifty years ago as an energy source for patients suffering from fat malabsorption syndrome which still finds applications in medical, nutritional products due to the purity and the unique attributes of Caprylic/Capric Triglycerides

Is caprylic/capric triglyceride safe?

Caprylic triglyceride carries a very low, if any, toxicity for topical use. The FDA notes that it’s generally recognized as safe in low amounts as a food additive. That means it’s not toxic to consume the trace amounts that might be in your lipstick or lip balm.

Unless you have a severe allergy to coconut oil, you’re at very little risk for an allergic reaction triggered by using caprylic triglyceride.

There’s some environmental concern for the use of caprylic triglyceride. We don’t know enough about the way it’s broken down in nature and if it might eventually build up and pose a threat to wildlife. More research is needed to determine the safest ways to dispose of products that contain caprylic triglyceride.

Caprylic/capric triglyceride is an oily liquid derived from caprylic and capric fatty acids (typically sourced from coconut oil) and glycerin.

Caprylic acid and capric acid are saturated fatty acids found naturally in plant oils such as coconut and palm. These fatty acids are also found in the milk of some mammals, including goats, from which they get their name – ‘caprylic’ and ‘capric’ coming from the latin word for goats: capra. The caprylic/capric triglyceride we use is from plant (non-animal) origins.

Caprylic/capric triglyceride can be produced by reacting coconut oil with glycerin, which separates or ‘fractionates’ the glycerides. ‘Caprylic’ and ‘Capric’ are names to describe the length of the resulting fatty acid molecules: 8 carbons long for caprylic and 10 for capric. The fractionating process removes almost all the long chain triglycerides, leaving mostly medium chain triglycerides and making it a more saturated oil.

This saturation gives it a long shelf life and makes it more stable.

Fractionating the oil raises the comparative concentration of capric acid and caprylic acid, giving it greater antioxidant properties.

Caprylic/capric triglyceride can be used in skin care products as a gentle, non-greasy emollient.

It helps restore the skin’s protective barrier while replenishing moisture, leaving skin soft and smooth. Similarly, when used in hair care products caprylic/capric triglyceride creates a protective barrier on the hair surface, helping to retain moisture and prevent dryness.

Other names: Caprylic/Capric Acid Triglyceride, Glycerol Calrylate Caprinate, Glycerol Caprylate Caprinate, Octanoic/Decanoic Acid Triglyceride, Decanoic Acid, Ester with 1,2,3-propanetriol Octanoate

Caprylic Capric Triglycerides are a specific fraction of coconut / palm oil fatty acids resulting in only the more stable, and skin loving, caprylic & capric fatty acids which creates a dry, silky oil form of esters.

Caprylic Capric Triglycerides (CCT) are mistakenly called Fractionated Coconut Oil.

Caprylic Capric Triglycerides are a specialized esterification of Coconut Oil using just the Caprylic and Capric Fatty Acids, while Fractionated Coconut Oil is a, standard, distillation of Coconut Oil which results in a combination of all of the fatty acids, pulled through the distillation process.

Fractionated Coconut Oil has the same feel, and performance, of traditional vegetable oils with a lighter feel and extended shelf life, than most common carrier oils.

Caprylic Capric Triglycerides do not feel like a standard carrier oil, at all.

Caprylic Capric Triglycerides are an ester and have a very light, silky oil, feel that is not at all greasy / oily feeling on the skin.

There are many suppliers that haven’t recognized the difference between these two products, which is unfortunate for the discriminate formulator because the two are not interchangeable. Just because they both come from coconut oil doesn’t make them the same thing.

If that rationale were accurate then they would have to say that Neroli, Petitgrain, and Bitter Orange are all the same thing because they all come from the same tree, or that Emulsifying Wax and CocoBetaine are the same thing because they come from the same Coconut.

The difference between Caprylic Capric Triglycerides and Fractionated Coconut Oil are obvious in the chemistry, and to the touch.

If a comparison is done, by applying the two to the skin, it is very clear that the Caprylic Capric Triglycerides offers a silky feel, a testament to the specialized esters, while the Fractionated Coconut Oil has the feel of a common carrier oil. Caprylic Capric Triglycerides have a dry, silky oil, feel that is almost powdery because it is still present on the skin but not oily.

These are just the esthetic properties. When it comes down to chemical performance the Caprylic Capric Triglycerides are a suitable oil replacement, when you need to use it with emulsifiers that are intolerant of carrier oils, where the Fractionated Coconut Oil is not.

Ingredients To Die For offers Fractionated Coconut Oil as well, because it has value when you’re looking for it’s particular attributes as a vegetable oil, just not as a substitute for carrier oils, for oily skin, for sensitive skin, or oil free product claims and not as a substitute for Caprylic Capric Triglycerides.

Caprylic Capric Triglycerides are produced by the esterification of glycerol (plant sugars) with mixtures of caprylic (C:8) and capric (C:10) fatty acids from coconut or palm kernel oils. The special combination, and esterification, are responsible for the silky oil feel.

This is a specialized process used to achieve the skin benefits of the specific fatty acid esters that also results in superior oxidative stability, low color, and odor, as it is then further refined to remove residual fatty acids resulting in a pure ester, with a silky oil feel, that is a great choice for sensitive skin and oil free applications.

The unique metabolic, and functional properties, of Caprylic Capric Triglycerides, are a consequence of their chemical structure, and makes them a versatile ingredient in numerous Pharmaceutical and Cosmetic applications.

In skin care applications Caprylic Capric Triglycerides offer several key benefits: they offer a noticeable silkiness in products, they exhibit excellent anti-oxidant properties to extend the natural shelf life, they offer skin nurturing benefits due to the skin loving nature of the specific fatty acid esters, not seen with common Fractionated Coconut Oil, or other carrier oils, and they are especially suited to sensitive skin and oily skin.

Caprylic Capric Triglyceride were developed over fifty years ago as an energy source for patients with fat malabsorption syndrome and they still find use, today, in medical nutritional products, owing to the purity of this specialty ester and the unique attributes of Caprylic Capric Triglycerides.

Caprylic Capric Triglycerides offers low viscosity and excellent oxidative stability, and anti-oxidant protection, with an unlimited shelf life.

Caprylic Capric Triglyceride are efficient solvents and therefore, act as carriers for fat-soluble vitamins and actives.

Their emollient properties enable Caprylic Capric Triglycerides to improve the esthetics of topical products while functioning as a component of the delivery system.

Caprylic Capric Triglycerides may also be used to help solubilize actives that are not readily soluble in traditional carrier oils.

Caprylic Capric Triglycerides is a perfect vehicle for using Alpha Lipoic Acid, to keep it in solution.

To do this add 10% Alpha Lipoic Acid to 90% Caprylic Capric Triglycerides, mixing to combine and then add this solution to your product at cool down.

Do not apply heat, once you’ve added the solution, which will cause the Alpha Lipoic Acid to fall out of solution.

ATTRIBUTES

Suitable Replacement for Partially or Completely Unstable Vegetable Oils

Improves Feel and Spreadability of Emulsions

Improves the Stability of Natural Compositions

Excellent Carrier for Oil Infusions / Extractions

Suitable Carrier for Essential Oils

Solvent for Oil Soluble Actives

Virtually Unlimited Shelf Life

Solvent for UV Filters

Very High Polarity

Oil Substitute

Low color, low odor, constant quality, medium chain triglyceride oil. Acts as emollient, lubricant and solvent. Used in antiperspirants & deodorants – roll on and stick, shaving, baby care, body care, facial care, sun care, facial make-up, lip products, sprayable emulsions, cleansers, toners, eye care, specific skin care treatments, feets, hands as well as nails, shampoos and hair coloring.

INCI:

Caprylic/Capric Triglyceride

Claims:

Solvents & Carriers > Esters

Lubricants / Slip Agents

Emollients > Esters

Applications/Recommended for:

Decorative cosmetics/Make-up>Eye pencils

Decorative cosmetics/Make-up>Eyes Shadows & Creams

Decorative cosmetics/Make-up>Lipsticks & Glosses

Decorative cosmetics/Make-up>Mascaras Decorative cosmetics/Make-up>Nail treatments

Hair care (Shampoos, Conditioners & Styling)>Bleaches, dyes & colors products

Hair care (Shampoos, Conditioners & Styling)>Shampoos

Skin care (Facial care, Facial cleansing, Body care, Baby care)>Baby care

Skin care (Facial care, Facial cleansing, Body care, Baby care)>Body care

Skin care (Facial care, Facial cleansing, Body care, Baby care)>Facial care>Eye Care Gels & creams

Skin care (Facial care, Facial cleansing, Body care, Baby care)>Facial cleansing>Cleansing lotions & toners

Sun care (Sun protection, After-sun & Self-tanning)

Toiletries (Shower & Bath, Oral care…)>Antiperspirants & deodorants>Deodorants sticks and roll-on

Toiletries (Shower & Bath, Oral care…)>Foot care

Toiletries (Shower & Bath, Oral care…)>Shaving Decorative cosmetics/Make-up>Eye liners

Recommended use levels:

0.5 – 20%, depending on the application

Similar or Equivalent to:

Crodamol GTCC (Croda Inc.)

AEC Coconut Oil Fractionated (A & E Connock (Perfumery & Cosmetics) Ltd.)

Akomed E (AarhusKarlshamn Sweden AB)

Akomed R (AarhusKarlshamn Sweden AB)

Botanester GC (Botanigenics, Inc)

Captex 300 (Abitec Corporation)

Captex 355 (Abitec Corporation)

Dub MCT (Stearinerie Dubois Fils)

Endimate 33V (Coast Southwest, Inc)

Ethox 2156 (Ethox Chemicals, Inc.)

Jeechem CTG (Jeen International Corporation)

Labrafac Lipophile WL 1349 (Gattefosse s.a.s.)

Lexol GT-865 (Inolex Inc.)

Liponate GC (Lipo Chemicals, Inc.)

Lumulse CC-33 (Lambent Technologies)

Megester MCT (Megachem Pty Ltd)

Miglyol 810 (Cremer Oleo)

Miglyol 812 (Cremer Oleo)

Myritol 312 (BASF Corporation)

Myritol 318 (BASF Corporation)

Neobee M-5 Cosmetic (Stepan Company)

Nikkol Triester F-810 (Nikko Chemicals Co., Ltd.)

Nikkol Triester F-810J (Nikko Chemicals Co., Ltd.)

O.D.O. (The Nisshin Oillio Group, Ltd.)

Pelemol CCT (Phoenix Chemical, Inc.)

Protachem CTG (Protameen Chemicals)

Radia 7104 (Oleon NV)

Ritamollient CCT (Rita Corporation)

Saboderm TCC (Sabo s.p.a.)

Sunfat MCT-7 (Taiyo Kagaku Company, Ltd.)

TCG-M (Kokyu Alcohol Kogyo Co., Ltd.)

Tegosoft CT (Evonik Industries AG)

Unitolate 160-K (Universal Preserv-A-Chem, Inc.)

Velsan CCT (Clariant International Ltd,)

Properties of the natural ingredient makes it suitable for use in various applications.

Fast Spreading, light skin feel – personal care ingredient

Oxidative stability, low viscosity, clean organoleptic quality – solvent for flavour, pharmaceautical, lubricant

Lower caloric value, rapid available source of energy – health management

CAPRYLIC /CAPRIC TRIGLYCERIDES Chemical Properties,Uses,Production

Chemical Properties

A colorless to slightly yellowish oily liquid that is practically odorless and tasteless. It solidifies at about 0°C. The oil is free from catalytic residues or the products of cracking.

Production Methods

Medium-chain triglycerides are obtained from the fixed oil extracted from the hard, dried fraction of the endosperm of Cocos nucifera L. Hydrolysis of the fixed oil followed by distillation yields the required fatty acids, which are then re-esterified to produce the medium-chain triglycerides.

Although the PhEur 6.0 specifies that medium-chain fatty acids are obtained from coconut oil, medium-chain triglycerides are also to be found in substantial amounts in the kernel oils of certain other types of palm-tree, e.g. palm kernel oil and babassu oil. Some animal products, such as milk-fat, also contain small amounts (up to 4%) of the medium-chain fatty acid esters.

Pharmaceutical Applications

Medium-chain triglycerides have been used in a variety of pharmaceutical formulations including oral, parenteral, and topical preparations.

In oral formulations, medium-chain triglycerides are used as the base for the preparation of oral emulsions, microemulsions, selfemulsifying systems, solutions, or suspensions of drugs that are unstable or insoluble in aqueous media, e.g. calciferol. Mediumchain triglycerides have also been investigated as intestinalabsorption enhancersand have additionally been used as a filler in capsules and sugar-coated tablets, and as a lubricant or antiadhesion agent in tablets.

In parenteral formulations, medium-chain triglycerides have similarly been used in the production of emulsions, solutions, or suspensions intended for intravenous administration.In rectal formulations, medium-chain triglycerides have been used in the preparation of suppositories containing labile materials. In cosmeticsand topical pharmaceutical preparations, medium-chain triglycerides are used as a component of ointments, creams, and liquid emulsions.

Therapeutically, medium-chain triglycerides have been used as nutritional agents.Diets containing medium-chain triglycerides are used in conditions associated with the malabsorption of fat, such as cystic fibrosis, since medium-chain triglycerides are more readily digested than long-chain triglycerides. Medium-chain triglycerides have been particularly investigated for their use in total parenteral nutrition (TPN) regimens in combination with longchain triglycerides.

Although similar to long-chain triglycerides, medium-chain triglycerides have a number of advantages in pharmaceutical formulations, which include better spreading properties on the skin; no impedance of skin respiration; good penetration properties; good emollient and cosmetic properties; no visible film on the skin surface; good compatibility; good solvent properties; and good stability against oxidation.

Safety

Medium-chain triglycerides are used in a variety of pharmaceutical formulations including oral, parenteral, and topical products, and are generally regarded as essentially nontoxic and nonirritant materials.

In acute toxicology studies in animals and humans, no irritant or other adverse reactions have been observed; for example, when they were patch-tested on more than 100 individuals, no irritation was produced on either healthy or eczematous skin. Medium-chain triglycerides are not irritating to the eyes.

Similarly, chronic toxicology studies in animals have shown no harmful adverse effects associated with medium-chain triglycerides following inhalation or intraperitoneal, oral, and parenteral administration.

In humans, administration of 0.5 g/kg body-weight mediumchain triglycerides to healthy individuals produced no change in blood or serum triglycerides compared to subjects receiving the same dose of the long-chain triglyceride triolein.

In patients consuming diets based on medium-chain triglycerides, adverse effects reported include abdominal pain and diarrhea.

LD50 (mouse, IV): 3.7 g/kg

LD50 (mouse, oral): 29.6 g/kg

LD50 (rat, oral): 33.3 g/kg

storage

storage temperatures that can be experienced in tropical and temperate climates. Ideally, however, they should be stored at temperatures not exceeding 25°C and not exposed to temperatures above 40°C for long periods. At low temperatures, samples of medium-chain triglycerides may become viscous or solidify. Samples should therefore be well melted and mixed before use, although overheating should be avoided.

In the preparation of microemulsions and self-emulsifying systems, emulsions, or aqueous suspensions of medium-chain triglycerides, care should be taken to avoid microbiological contamination of the preparation, since lipase-producing microorganisms, which become active in the presence of moisture, can cause hydrolysis of the triglycerides. Hydrolysis of the triglycerides is revealed by the characteristic unpleasant odor of free mediumchain fatty acids.

Medium-chain triglycerides may be sterilized by maintaining at 170°C for 1 hour.

Medium-chain triglycerides should be stored protected from light in a well-filled and well-closed container. When stored dry, in sealed containers, medium-chain triglycerides remain stable for many years.

Incompatibilities

Preparations containing medium-chain triglycerides should not come into contact with polystyrene containers or packaging components since the plastic rapidly becomes brittle upon contact. Low-density polyethylene should also not be used as a packaging material as the medium-chain triglycerides readily penetrate the plastic, especially at high temperatures, forming an oily film on the outside. High-density polyethylene is a suitable packaging material. Closures based on phenol resins should be tested before use for compatibility with medium-chain triglycerides. Polyvinyl chloride packaging should also be tested for compatibility since mediumchain triglycerides can dissolve some plasticizers, such as phthalates, out of the plastic.

Materials recommended as safe for packaging medium-chain triglycerides are low-density polyethylene, polypropylene, glass, and metal.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (topical preparations). Included in nonparenteral and parenteral medicines licensed in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

The rise in consumption of personal care products like face cream, body lotion, moisturizer, sun screen, lipstick, lip balm, perfumes, cleanser & face wash, serum, hair products and others are expected to continue fuelling the growth of capric triglyceride market. The changes in environment and rise in pollution level, leading to diminishing skin health have been a major factor in influencing the surge in the demand for these abovementioned products and in turn play a major role in the upliftment of global capric triglyceride market.

The fast paced life of the urban landscape has increased the dependency on dietary supplements. The Capric Triglycerides are used in the dietary supplements as they have the properties to boost the endurance and stamina among people. It is also used in the food & beverages industry as a food sanitizer in food handling units like dairy equipment, food processing equipment, wineries, breweries and beverage processing units. The Capric triglycerides also assist in a prolonged shelf life of the food products, and minimum toxicity.

However, Capric Triglycerides may induce gastric distress and allergies in some people. Also, they face a threat from the substitute products, especially in the field of cosmetics and personal care industry which is expected to hamper the market growth in the coming years.

The demand for products derived from natural ingredients is rising in order to avoid the side effects of synthetic products, especially in cosmetics industry, which is expected to be a promising opportunity for the global Caprylic Triglyceride market.

Alternate Names: Caprylic/Capric Triglyceride, Caprylic/Capric Acid Triglyceride; Decanoic Acid, Ester With 1,2,3-Propanetriol Octanoate; Decanoic Acid, Ester With 1,2,3-Prpanetriol Octanoate; Decanonic Acid, Ester With 1,2,3-Propanetriol Octanoate; Glycerol Calrylate Caprinate; Glycerol Caprylate Caprinate; Octanoic/Decanoic Acid Triglyceride; Ester With 1,2,3-Propanetriol Octanoate Decanoic Acid; Ester With 1,2,3-Prpanetriol Octanoate Decanoic Acid; Ester With 1,2,3-Propanetriol Octanoate Decanonic Acid EWG

CAPRYLIC/CAPRIC TRIGLYCERIDE

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CAPRYLIC/CAPRIC TRIGLYCERIDE

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