CYCLOHEXYLAMINE (SKLOHEKSLAMN)
CYCLOHEXYLAMINE (SKLOHEKSLAMN)
CAS No. : 108-91-8
EC No. : 203-629-0
Synonyms:
CYCLOHEXYLAMINE; Cyclohexanamine; 108-91-8; Aminocyclohexane; Hexahydroaniline; Hexahydrobenzenamine; Aminohexahydrobenzene; Cyclohexyl amine; 1-Cyclohexylamine; 1-Aminocyclohexane; Aniline, hexahydro-; Benzenamine, hexahydro-; Aminocylcohexane; Cyclohexylamines; cyclohexyl-amine; UNII-I6GH4W7AEG; 1-AMINO-CYCLOHEXANE; CCRIS 3645; HSDB 918; cyclohexaneamine; Cyclohexylamine.HCl; EINECS 203-629-0; UN2357; I6GH4W7AEG; BRN 0471175; Cyclohexylamin; AI3-15323; CHEBI:15773; Cyclohexylamine [UN2357] [Corrosive]; Cyclohexylamine, 99%; Cyclohexylamine [UN2357] [Corrosive]; DSSTox_CID_3996; DSSTox_RID_77250; DSSTox_GSID_23996; CAS-108-91-8; HAI; cylohexylamine; cyclohexylarnine; cyclo-hexylamine; cyclohexane-amine; n-cyclohexylamine; cyclohexanyl amine; Hexahydro-Aniline; monocyclohexylamine; 4-Cyclohexylamine; Cyclohexylamine,(S); Hexahydro-Benzenamine; Cyclohexanamine, 9CI; CyNH2; ACMC-1BUGG; Cyclohexylamine, 99.5%; $l^{1}-azanylcyclohexane; bmse000451; EC 203-629-0; 4-12-00-00008 (Beilstein Handbook Reference); BIDD:ER0290; GTPL5507; CHEMBL1794762; DTXSID1023996; BDBM81970; CTK0H8608; BCP30928; Tox21_202380; Tox21_300038; ANW-15993; BBL002476; LS-473; MFCD00001486; SBB040492; STK387114; ZINC12358775; AKOS000119083; Cyclohexylamine, ReagentPlus(R), 99%; MCULE-7654331405; UN 2357; VS-0326; Aminocyclohexane pound>>Hexahydroaniline; KS-00000X91; NCGC00247889-01; NCGC00247889-02; NCGC00253922-01; NCGC00259929-01; AM802905; BP-21278; CAS_108-91-8; NCI60_004907; SC-47180; Cyclohexylamine 1000 microg/mL in Methanol; Cyclohexylamine, ReagentPlus(R), >=99.9%; FT-0624217; NS00001272; ST45255365; T7305; X6008; C00571; 46880-EP2272837A1; 46880-EP2277848A1; 46880-EP2277862A2; 46880-EP2281563A1; 46880-EP2284159A1; 46880-EP2284174A1; 46880-EP2287141A1; 46880-EP2292228A1; 46880-EP2292621A1; 46880-EP2295406A1; 46880-EP2295418A1; 46880-EP2298731A1; 46880-EP2298746A1; 46880-EP2298778A1; 46880-EP2305219A1; 46880-EP2305651A1; 46880-EP2308812A2; 46880-EP2308833A2; 46880-EP2308854A1; 46880-EP2311804A2; 46880-EP2311810A1; 46880-EP2380874A2; 56751-EP2284166A1; 56751-EP2298769A1; 56751-EP2308878A2; J-002206; J-520164; Q1147539; F2190-0381
EN
Cyclohexylamine IUPAC Name cyclohexanamine
Cyclohexylamine InChI 1S/C6H13N/c7-6-4-2-1-3-5-6/h6H,1-5,7H2
Cyclohexylamine InChI Key PAFZNILMFXTMIY-UHFFFAOYSA-N
Cyclohexylamine Canonical SMILES C1CCC(CC1)N
Cyclohexylamine Molecular Formula C6H11NH2
Cyclohexylamine CAS 108-91-8
Cyclohexylamine Deprecated CAS 143247-75-0, 157973-60-9, 1357848-57-7, 1533423-50-5
Cyclohexylamine European Community (EC) Number 203-629-0
Cyclohexylamine ICSC Number 0245
Cyclohexylamine RTECS Number GX0700000
Cyclohexylamine UN Number 2357
Cyclohexylamine UNII I6GH4W7AEG
Cyclohexylamine DSSTox Substance ID DTXSID1023996
Cyclohexylamine Physical Description Liquid
Cyclohexylamine Color/Form Colorless or yellow liquid.
Cyclohexylamine Odor Strong, fishy, amine odor
Cyclohexylamine Boiling Point 274.1 °F at 760 mm Hg
Cyclohexylamine Melting Point 0.1 °F
Cyclohexylamine Flash Point 88 °F
Cyclohexylamine Solubility Very soluble
Cyclohexylamine Density 0.8647 at 77 °F
Cyclohexylamine Vapor Density 3.42
Cyclohexylamine Vapor Pressure 11 mm Hg
Cyclohexylamine LogP 1.49
Cyclohexylamine Henrys Law Constant 4.16e-06 atm-m3/mole
Cyclohexylamine Autoignition Temperature 560 °F
Cyclohexylamine Decomposition When heated to decomposition it emits toxic fumes of NOx /nitrogen oxides/.
Cyclohexylamine Viscosity 2.10 Pa*s at 20 °C
Cyclohexylamine pH STRONG BASE
Cyclohexylamine Ionization Potential 8.37 eV
Cyclohexylamine Refractive Index Index of refraction: 1.4565 @ 25 °C/D
Cyclohexylamine Dissociation Constants pKa = 10.63 (conjugate acid)
Cyclohexylamine Molecular Weight 99.17 g/mol
Cyclohexylamine XLogP3 1.5
Cyclohexylamine Hydrogen Bond Donor Count 1
Cyclohexylamine Hydrogen Bond Acceptor Count 1
Cyclohexylamine Rotatable Bond Count 0
Cyclohexylamine Exact Mass 99.104799 g/mol
Cyclohexylamine Monoisotopic Mass 99.104799 g/mol
Cyclohexylamine Topological Polar Surface Area 26 Ų
Cyclohexylamine Heavy Atom Count 7
Cyclohexylamine Formal Charge 0
Cyclohexylamine Complexity 46.1
Cyclohexylamine Isotope Atom Count 0
Cyclohexylamine Defined Atom Stereocenter Count 0
Cyclohexylamine Undefined Atom Stereocenter Count 0
Cyclohexylamine Defined Bond Stereocenter Count 0
Cyclohexylamine Undefined Bond Stereocenter Count 0
Cyclohexylamine Covalently-Bonded Unit Count 1
Cyclohexylamine Compound Is Canonicalized Yes
Cyclohexylamine is an organic compound, belonging to the aliphatic amine class. It is a colorless liquid, although, like many amines, samples are often colored due to contaminants. It has a fishy odor and is miscible with water. Like other amines, it is a weak base, compared to strong bases such as NaOH, but it is a stronger base than its aromatic analog, aniline.It is a useful intermediate in the production of many other organic compounds.Cyclohexylamine is used as an intermediate in synthesis of other organic compounds. It is the precursor to sulfenamide-based reagents used as accelerators for vulcanization. It is a building block for pharmaceuticals (e.g., mucolytics, analgesics, and bronchodilators). The amine itself is an effective corrosion inhibitor. Some sweeteners are derived from this amine, notably cyclamate. The herbicide hexazinone and the anesthetic hexylcaine are derived from Cyclohexylamine .It is corrosive. Cyclohexylamine is listed as an extremely hazardous substance as defined by Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act. It has been used as a flushing aid in the printing ink industry.Cyclohexylamine appears as a clear colorless to yellow liquid with an odor of ammonia. Flash point 90°F. Irritates the eyes and respiratory system. Skin contact may cause burns. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.Cyclohexylamine is a primary aliphatic amine consisting of cyclohexane carrying an amino substituent. It has a role as a human xenobiotic metabolite and a mouse metabolite. It is a conjugate base of a cyclohexylammonium.On distillation with water, Cyclohexylamine forms azeotropic mixt, boiling @ 96.4 °C @ 760 mm Hg; reacts with excess ammonia and zinc chloride @ 350 °C to produce alpha-picoline.Cyclohexylamine showed dose dependent kinetics after administration of single oral doses of 35, 200, or 500 mg/kg in rats, with a reduction in plasma clearance from 37 to 24 ml/min/kg, an increase in apparent half-life from 11.8 to 12 hr, and an increased area under the testicular concentration vs time curve. Saturation of Cyclohexylamine uptake by rat renal cortical slices in vitro and of renal tubular secretion in vivo occurred at concentrations and doses comparable to the oral dose studies. Cyclohexylamine clearance from a 10 mg/kg infusion was 2.58 + or – 1.13 ml/min and from a 200 mg/kg infusion, 2.49 + or – 1.65 ml/min. The Cyclohexylamine to inulin clearance ratios were 2 at a dose of 10 mg/kg and 1.23 at a dose of 200 mg/kg. During chronic dietary administration the concentrations of Cyclohexylamine in the plasma and testes showed a pronounced diurnal variation in rats, reaching a peak concentration at the end of the dark cycle at 6 AM (6.3 + or – 1.5 ug/ml in plasma an 45.7 + or – 3.4 ug/g in testes). The lowest concentrations of Cyclohexylamine were at 9 PM (1.5 + of – 0.5 ug/ml in plasma and 10.9 + or – 3.6 ug/g in testes). The steady state plasma clearance was 33 ml/min/kg. The concentrations of Cyclohexylamine in the plasma and testes of rats showed a nonlinear relationship to dietary intake. Elevated concentrations were found at intake greater than 200 mg/kg/day.Generally, Cyclohexylamine , is readily absorbed & rapidly excreted from the body. After admin to rats, Cyclohexylamine appears in body tissues with the highest concn in the lungs, spleen, liver, adrenals, heart, GI tract & kidneys.After oral admin (0.2 g/kg) to rabbits, Cyclohexylamine gave rise to unchanged Cyclohexylamine & N-hydroxyCyclohexylamine in the urine. When C14-labeled Cyclohexylamine was admin, 68% of the radioactivity was recovered in the urine after 60 hr. A small amount (0.5%) was eliminated in the breath & 45% of the admin dose was shown to be excreted in the urine as unconjugated Cyclohexylamine , 0.2% as N-hydroxyCyclohexylamine in conjugated form, & 2.5% as cyclohexanone oxime. The authors postulated the latter metabolite to be an artifact formed form the glucuronide of N-hydroxyCyclohexylamine during the hydrolysis procedure.The metabolites identified indicated that in rats, the metabolism of Cyclohexylamine was mainly through hydroxylation of the cyclohexane ring, in man by deamination & in guinea pigs & rabbits by ring hydroxylation & deamination. The metabolites to Cyclohexylamine were excreted in both free & conjugated forms.Most of the Cyclohexylamine given by gavage or intraperitoneal injection to rats and guinea pigs was excreted unchanged, and only 4-5% was metabolized within 24 hours. In rabbits, 30% was metabolized. Cyclohexylamine has been reported to be metabolized further to cyclohexanone and then to cyclohexanol in guinea pigs, rabbits and rats. A number of hydroxylated products of Cyclohexylamine have been reported in these species, which were excreted in part as glucuronides.Orally administration cyclamate appears to be readily absorbed by rabbits but less readily by guinea pigs, rats and humans. All of these species convert cyclamate to Cyclohexylamine , via the action of gastrointestinal microflora on unabsorbed cyclamate. The metabolism of Cyclohexylamine to other products differs somewhat in humans and other species, although most Cyclohexylamine is rapidly excreted unchanged in the urine. In rats, it is metabolized mainly by hydroxylation of the cyclohexane ring; in humans, it is metabolized by deamination; and in guinea pigs and rabbits, it is metabolized by ring hydroxylation and deamination.Mice were fed Cyclohexylamine (as the hydrochloride) at a constant intake of 400 mg/kg/day for 13 weeks. Food intake and body weight gain were not affected. The metabolism of (14)C labeled Cyclohexylamine administered as a single oral dose (2 uCi per mouse) was not significantly different among animals chronically fed Cyclohexylamine for 0, 3, 7, or 13 weeks. The major metabolite produced was 3-aminocyclohexanol; total metabolism was less than 2%. … Concentrations of Cyclohexylamine in plasma (ug/ml) after 3 weeks feeding were 0.20; after 7 weeks 0.18; and after 13 weeks, 4.51 + or – 2.94. Concentrations of the chemical in testes (ug/g wet weight) varied from 6.81 + or – 5.21 at 3 weeks to 4.51 + or – 2.94 at 13 weeks.Wistar and DA rats were fed Cyclohexylamine (as the hydrochloride) at constant intake of 400 mg/kg/day for 13 weeks. The metabolism of (14)C-labeled Cyclohexylamine administered as a single oral dose (8 uCi per rat) was similar for both strains of rat, with no consistent effect due to age or prolonged feeding with Cyclohexylamine . However, there was reduced elimination of (14)C in the treated Wistar and DA rats compared to that in the controls during the first 6 hr after dosing; the difference was statistically significant at 3 weeks in both strains and at 13 weeks in the DA strain. The major metabolites produced were 3- and 4-aminocyclohexanols; at 13 weeks the total metabolism was 17% to 18% for the Wistar rats, 4% to 6% in the DA rats. After 13 weeks, testicular atrophy was demonstrated in both strains of rat fed Cyclohexylamine ; DA rats appeared more sensitive to testicular toxicity than the Wistar rats. Concentrations of Cyclohexylamine and its metabolites in plasma and in testicular tissue were higher in Wistar rats than in DA rats.Cyclohexylamine showed dose dependent kinetics after administration of single oral doses of 35, 200 or 500 mg/kg in mice, with a reduction in plasma clearance from 61 to 53 ml/min/kg, an increase in apparent half-life from 1.4 to 3.5 hr, and an increased area under the testicular concentration vs time curve. During chronic dietary administration the concentrations of Cyclohexylamine in the plasma and testes showed little diurna variation. The steady state plasma clearance was 65 ml/min/kg. The concentrations of Cyclohexylamine in the plasma and testes of the mice showed a linear relationship to dietary intake, even at the highest intake, about 900 mg/kg/day.Prepared by catalytic hydrogenation of aniline at elevated temp and pressures. Fractionation of crude reaction product yields Cyclohexylamine , unchanged aniline, and high-boiling residue containing n-phenylCyclohexylamine (cyclohexylaniline) and diCyclohexylamine .
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Sikloheksilamin IUPAC Ad sikloheksanamin
Sikloheksilamin InChI 1S / C6H13N / c7-6-4-2-1-3-5-6 / h6H, 1-5,7H2
Sikloheksilamin InChI Anahtar PAFZNILMFXTMIY-UHFFFAOYSA-N
Sikloheksilamin Kanonik SMILES C1CCC (CC1) N
Sikloheksilamin Moleküler Formül C6H11NH2
Sikloheksilamin CAS 108-91-8
Sikloheksilamin Kullanmdan Kaldrlm CAS 143247-75-0, 157973-60-9, 1357848-57-7, 1533423-50-5
Sikloheksilamin Avrupa Topluluu (EC) Numaras 203-629-0
Sikloheksilamin ICSC Numaras 0245
Sikloheksilamin RTECS Numaras GX0700000
Sikloheksilamin UN Numaras 2357
Sikloheksilamin UNII I6GH4W7AEG
Sikloheksilamin DSSTox Madde Kimlii DTXSID1023996
Sikloheksilamin Fiziksel Tanm Sv
Sikloheksilamin Renk / Form Renksiz veya sar sv.
Sikloheksilamin Koku Güçlü, balkms, amin kokusu
Sikloheksilamin Kaynama Noktas 760 mm Hg’de 274.1 ° F
Sikloheksilamin Erime Noktas 0.1 ° F
Sikloheksilamin Parlama Noktas 88 ° F
Sikloheksilamin Çözünürlük Çok çözünür
Sikloheksilamin Younluk 0.8647, 77 ° F
Sikloheksilamin Buhar Younluu 3.42
Sikloheksilamin Buhar Basnc 11 mm Hg
Sikloheksilamin LogP 1.49
Sikloheksilamin Henrys Yasas Sabiti 4.16e-06 atm-m3 / mol
Sikloheksilamin Kendiliinden Tutuma Scakl 560 ° F
Sikloheksilamin Ayrma Ayrmaya kadar stldnda NOx / nitrojen oksit / toksik dumanlar çkarr.
Sikloheksilamin Viskozite 20 ° C’de 2,10 Pa * s
Sikloheksilamin pH GÜÇLÜ BAZ
Sikloheksilamin yonizasyon Potansiyeli 8,37 eV
Sikloheksilamin Krlma ndeksi Krlma ndeksi: 1.4565 @ 25 ° C / D
Sikloheksilamin Ayrlma Sabitleri pKa = 10.63 (konjugat asit)
Sikloheksilamin Molekül Arl 99,17 g / mol
Sikloheksilamin XLogP3 1.5
Sikloheksilamin Hidrojen Ba Donör Says 1
Sikloheksilamin Hidrojen Ba Alc Says 1
Sikloheksilamin Döndürülebilir Ba Says 0
Sikloheksilamin Tam Kütle 99.104799 g / mol
Sikloheksilamin Monoizotopik Kütle 99.104799 g / mol
Sikloheksilamin Topolojik Polar Yüzey Alan 26 Ų
Sikloheksilamin Ar Atom Says 7
Sikloheksilamin Resmi arj 0
Sikloheksilamin Karmakl 46.1
Sikloheksilamin zotop Atom Says 0
Sikloheksilamin Tanml Atom Stereocenter Says 0
Sikloheksilamin Tanmsz Atom Stereocenter Says 0
Sikloheksilamin Tanml Ba Stereocenter Says 0
Sikloheksilamin Tanmsz Ba Stereocenter Says 0
Sikloheksilamin Kovalent Bal Birim Says 1
Sikloheksilamin Bileii Kanonikalize Edilmitir Evet
Sikloheksilamin , alifatik amin snfna ait organik bir bileiktir. Renksiz bir svdr, ancak birçok amin gibi numuneler genellikle kirleticiler nedeniyle renklendirilir. Balk kokusu vardr ve su ile karabilir. Dier aminler gibi, NaOH gibi güçlü bazlara kyasla zayf bir bazdr, ancak aromatik analogu olan anilinden daha güçlü bir bazdr.Dier birçok organik bileiin üretiminde faydal bir ara maddedir. Sikloheksilamin dier organik bileiklerin sentezinde bir ara ürün olarak kullanlr. Vulkanizasyon için hzlandrc olarak kullanlan sülfenamid bazl reaktiflerin öncüsüdür. laçlar için bir yap tadr (örnein, mukolitikler, analjezikler ve bronkodilatörler). Aminin kendisi etkili bir korozyon önleyicidir. Baz tatlandrclar, bu aminden, özellikle siklamattan türetilir. Herbisit heksazinon ve anestezik heksilkain, Sikloheksilamin’den (Sikloheksilamin) elde edilir ve andrcdr. Sikloheksilamin , ABD Acil Durum Planlamas ve Topluluk Bilme Hakk Yasas’nn 302.Bölümünde tanmland gibi son derece tehlikeli bir madde olarak listelenmitir. Bask mürekkebi endüstrisinde bir ykama yardmcs olarak kullanlmtr. Sikloheksilamin , amonyak kokusu ile berrak renksiz ila sar bir sv olarak görünür. Parlama noktas 90 ° F. Gözleri ve solunum sistemini tahri eder. Deri temas yanklara neden olabilir. Sudan daha az youn. Havadan daha ar buharlar. Yanma srasnda oluan toksik nitrojen oksitleri Sikloheksilamin , bir amino ikame maddesi tayan sikloheksandan oluan birincil bir alifatik amindir. nsan ksenobiyotik metaboliti ve fare metaboliti olarak rol oynar. Bir sikloheksilamonyumun elenik bir tabandr.Sikloheksilamin su ile illasyon, azeotropik karm oluturur, kaynama @ 96.4 ° C @ 760 mm Hg; Alfa-pikolin üretmek için 350 ° C’de fazla amonyak ve çinko klorür ile reaksiyona girer. Sikloheksilamin , sçanlara 35, 200 veya 500 mg / kg’lk tek oral dozlarn uygulanmasndan sonra doza bal kinetikler gösterdi ve plazma klirensinde azalma 37’den 24 ml / dak / kg’ye, görünür yarlanma ömründe 11.8’den 12 saate bir art ve zaman erisine göre testis konsantrasyonu altnda artan bir alan. Sçan böbrek kortikal dilimleri tarafndan in vitro olarak Sikloheksilamin doygunluu (Sikloheksilamin) alm ve in vivo renal tübüler sekresyon, oral doz çalmalaryla karlatrlabilir konsantrasyonlarda ve dozlarda meydana gelmitir. 10 mg / kg infüzyondan Sikloheksilamin klirensi 2.58 + veya – 1.13 ml / dak ve 200 mg / kg infüzyondan 2.49 ± veya – 1.65 ml / dak. Sikloheksilamin / inülin klirens oranlar 10 mg / kg dozda 2 ve 200 mg / kg dozda 1.23 idi. Kronik diyet uygulamas srasnda, plazma ve testislerdeki Sikloheksilamin konsantrasyonlar, sçanlarda belirgin bir günlük deiim gösterdi ve karanlk döngünün sonunda sabah 6’da bir pik konsantrasyona ulat (6,3 + veya – 1,5 ug / ml plazma ve 45.7 + veya – 3.4 ug / g testislerde). En düük Sikloheksilamin konsantrasyonlar 21:00 (plazmada 1.5 + – 0.5 ug / ml ve testislerde 10.9 + veya – 3.6 ug / g) idi. Kararl durum plazma klirensi 33 ml / dak / kg’dr. Sçanlarn plazmas ve testislerindeki Sikloheksilamin konsantrasyonlar, diyet almyla dorusal olmayan bir iliki göstermitir. 200 mg / kg / gün’den daha fazla almda yüksek konsantrasyonlar bulunmutur.Genel olarak, Sikloheksilamin kolayca emilir ve vücuttan hzla atlr. Sçanlara uygulandktan sonra, Sikloheksilamin, vücut dokularnda akcierlerde, dalakta, karacierde, adrenallerde, kalpte, gastrointestinal sistemde ve böbreklerde en yüksek oranda ortaya çkar. idrarda deimemi Sikloheksilamin ve N-hidrokSikloheksilamin olumasna neden oldu. C14 etiketli Sikloheksilamin uygulandnda, radyoaktivitenin% 68’i 60 saat sonra idrarda geri kazanld. Nefeste küçük bir miktar (% 0,5) elimine edildi ve uygulama dozunun% 45’inin, konjuge olmayan Sikloheksilamin ,% 0,2 N-hidrokSikloheksilamin olarak ve% 2,5’i olarak idrarla atld gösterilmitir. siklohekzanon oksim olarak. Yazarlar, son metabolitin hidroliz prosedürü srasnda N-hidrokSikloheksilamin glukuronidinden oluan bir artefakt olduunu öne sürdüler. insanda deaminasyon yoluyla ve kobaylarda ve tavanlarda halka hidroksilasyon ve deaminasyon yoluyla. Sikloheksilamin metabolitleri hem serbest hem de konjuge formlarda atld. Sçanlara ve kobaylara gavaj veya intraperitoneal enjeksiyonla verilen Sikloheksilamin ‘in çou deimeden atld ve sadece% 4-5’i 24 saat içinde metabolize edildi. Tavanlarda% 30’u metabolize edildi. Sikloheksilamin’in (Sikloheksilamin) kobaylarda, tavanlarda ve sçanlarda sikloheksanona daha sonra da sikloheksanole metabolize edildii bildirilmitir. Bu türlerde, ksmen glukuronidler olarak atlan bir dizi hidroksile Sikloheksilamin ürünü rapor edilmitir. Bu türlerin tümü, emilmeyen siklamat üzerindeki gastrointestinal mikroflorann etkisiyle siklamat Sikloheksilamine (Sikloheksilamin) dönütürür. Sikloheksilamin ‘in dier ürünlere metabolizmas, insanlarda ve dier türlerde biraz farkllk gösterse de, Sikloheksilamin idrarla hzla atlr. Sçanlarda, esas olarak sikloheksan halkasnn hidroksilasyonu ile metabolize edilir; insanlarda deaminasyonla metabolize edilir; ve kobaylarda ve tavanlarda halka hidroksilasyonu ve deaminasyonu ile metabolize edilir. Fareler, 13 hafta boyunca 400 mg / kg / gün sabit bir almda Sikloheksilamin (hidroklorür olarak) ile beslendi. Gda alm ve vücut arl art etkilenmedi. Tek bir oral doz (fare bana 2 uCi) olarak uygulanan (14) C etiketli Sikloheksilamin metabolizmas, 0, 3, 7 veya 13 hafta boyunca kronik olarak Sikloheksilamin beslenen hayvanlar arasnda önemli ölçüde farkl deildi. Üretilen ana metabolit, 3-aminosikloheksanoldür; toplam metabolizma% 2’den azd. … 3 haftalk beslenmeden sonra plazmadaki (ug / ml) Sikloheksilamin konsantrasyonlar 0.20; 7 hafta sonra 0.18; ve 13 hafta sonra, 4.51 + veya – 2.94. KonsantrasyonTestislerdeki kimyasal oran (ug / g slak arlk), 3. haftada 6.81 + veya – 5.21’den 13. haftada 4.51 + veya – 2.94’e kadar deimitir. Wistar ve DA sçanlar, sabit bir ekilde Sikloheksilamin (hidroklorür olarak) ile beslenmitir. 13 hafta boyunca 400 mg / kg / gün alm. Tek bir oral doz (sçan bana 8 uCi) olarak uygulanan (14) C-etiketli Sikloheksilamin metabolizmas, her iki sçan suu için benzerdi, ya veya Sikloheksilamin ile uzun süreli beslenmeye bal olarak tutarl bir etki yoktu. Bununla birlikte, muamele edilmi Wistar ve DA sçanlarnda, dozlamadan sonraki ilk 6 saat boyunca kontrollerdekine kyasla (14) C’nin eliminasyonu azald; fark, her iki suta 3. haftada ve DA suunda 13. haftada istatistiksel olarak anlamlyd. Üretilen ana metabolitler 3 ve 4-aminosikloheksanollerdir; 13. haftada Wistar sçanlarnda toplam metabolizma% 17 ila% 18, DA sçanlarnda% 4 ila% 6 idi. 13 hafta sonra testiküler atrofi, Sikloheksilamin ile beslenen sçanlarn her iki suunda da gösterilmitir; DA sçanlar, testis toksisitesine Wistar sçanlarndan daha duyarl göründü. Sikloheksilamin ve plazma ve testiküler dokudaki metabolitlerinin konsantrasyonlar DA sçanlarna göre Wistar sçanlarnda daha yüksekti. Sikloheksilamin 35, 200 veya 500 mg / kg’lk tek oral dozlarn farelerde uygulanmasndan sonra doza bal kinetikler gösterdi. , plazma klirensinde 61’den 53 ml / dak / kg’a bir azalma, görünür yarlanma ömründe 1.4’ten 3.5 saate bir art ve zaman erisine kar testis konsantrasyonu altnda artan bir alan ile. Kronik diyet uygulamas srasnda plazma ve testislerdeki Sikloheksilamin konsantrasyonlar küçük diurna varyasyonu göstermitir. Kararl durum plazma klirensi 65 ml / dak / kg’dr. Farelerin plazmas ve testislerinde bulunan Sikloheksilamin konsantrasyonlar, en yüksek almda (yaklak 900 mg / kg / gün) bile diyet almyla dorusal bir iliki göstermitir. Yüksek scaklk ve basnçlarda anilinin katalitik hidrojenasyonu ile hazrlanmtr. Ham reaksiyon ürününün parçalanmas, Sikloheksilamin , deimemi anilin ve n-fenil Sikloheksilamin (sikloheksilanilin) ve diSikloheksilamin içeren yüksek kaynama noktal kalnt verir.