D-PANTHENOL
D-PANTHENOL
CAS No. : 81-13-0
EC No. : 201-327-3
Synonyms:
Dexpanthenol; D-Panthenol; 81-13-0; Pantothenol; Ilopan; D-Pantothenyl alcohol; Bepanthen; (+)-Panthenol; Bepanthene; Bepantol; Pantol; Provitamin B; Panthoderm; Thenalton; Motilyn; Panadon; Zentinic; Cozyme; d-Pantothenol; Pantothenyl alcohol; d panthenol; D-P-A Injection; D(+)-Panthenol; Synapan; D(+)-Pantothenyl alcohol; D-Panthenol 50; Pantenyl; Urupan; (R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide; (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide; Panthenol (D); Propanolamine, N-pantoyl-; N-Pantoyl-propanolamine; UNII-1O6C93RI7Z; Panthenol (JAN); Pantothenylol; Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-; Intrapan; Prestwick_529; Ilopan (TN); Provitamin B5; Dextro pantothenyl alcohol; Alcopan-250; NSC 302962; D-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide; Dexpantenol; Dexpanthenolum; 1O6C93RI7Z; CHEBI:27373; Pantothenol, D-; Pro-itamin B5; MFCD00065006; component of Pantho-F; NCGC00142622-03; D-Panthenol, 98+%; 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, (R)-; 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, D-(+)-; Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (R)-; Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, D-(+)-; DSSTox_CID_2906; Dexpantenol [INN-Spanish]; Dexpanthenolum [INN-Latin]; DSSTox_RID_76783; Q47495755; A6CF1A81-5B98-4C28-A379-EA28FA9DD210; (R)-3-(2,4-Dihydroxy-3,3-dimethylbutyramido)-1-propanol; UNII-WV9CM0O67Z component SNPLKNRPJHDVJA-ZETCQYMHSA-N; Dexpanthenol, European Pharmacopoeia (EP) Reference Standard; (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-butanamide; (R)-()-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide; (R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide; (R)-2,4-dihydroxy-3,3-dimethyl-N-(3-hydroxypropyl)-butanamide; (R)-2,4-Dihydroxy-N-(3-hydroxy-propyl)-3,3-dimethyl-butyramide; d(+)-2,4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethylbutyramide; D-(+)-2,4-Dihydroxy-3,3-dimethyl-N-(3-hydroxypropyl)butyramide; D-Panthenol, >=98% (perchloric acid titration), >=98% (TLC); Dexpanthenol, United States Pharmacopeia (USP) Reference Standard; (D)-(+)-2, 4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide; Dexpanthenol, Pharmaceutical Secondary Standard; Certified Reference Material
EN
D-Panthenol IUPAC Name (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
D-Panthenol InChI 1S/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)/t7-/m0/s1
D-Panthenol InChI Key SNPLKNRPJHDVJA-ZETCQYMHSA-N
D-Panthenol Canonical SMILES CC(C)(CO)C(C(=O)NCCCO)O
D-Panthenol Isomeric SMILES CC(C)(CO)[C@H](C(=O)NCCCO)O
D-Panthenol Molecular Formula C9H19NO4
D-Panthenol CAS 81-13-0
D-Panthenol Deprecated CAS 1113-70-8, 17307-32-3, 50584-68-4
D-Panthenol European Community (EC) Number 201-327-3
D-Panthenol UNII 1O6C93RI7Z
D-Panthenol DSSTox Substance ID DTXSID3022906
D-Panthenol Physical Description Solid
D-Panthenol Color/Form Hygroscopic oil
D-Panthenol Taste Slightly bitter taste
D-Panthenol Boiling Point Decomposes
D-Panthenol Melting Point <25°C
D-Panthenol Solubility 4.87 M
D-Panthenol Density 1.2 at 20 °C/20 °C
D-Panthenol Vapor Pressure 1.5X10-8 mm Hg at 25 °C (est)
D-Panthenol LogP log Kow = -1.92 (est)
D-Panthenol Stability/Shelf Life Reasonably stable to usual sterilization time and temp in aqueous solution at pH 3.0-4.0; long heating causes racemization.
D-Panthenol Optical Rotation Specific optical rotation: +29.5 deg at 20 °C/D (water, 5%)
D-Panthenol Decomposition When heated to decomposition it emits toxic fumes of /nitric oxide/.
D-Panthenol pH pH 9.5
D-Panthenol Refractive Index Index of refraction: 1.497 at 20 °C/D
D-Panthenol Collision Cross Section 144.7 Ų [M+H]+
D-Panthenol Molecular Weight 205.25 g/mol
D-Panthenol XLogP3-AA -0.9
D-Panthenol Hydrogen Bond Donor Count 4
D-Panthenol Hydrogen Bond Acceptor Count 4
D-Panthenol Rotatable Bond Count 6
D-Panthenol Exact Mass 205.131408 g/mol
D-Panthenol Monoisotopic Mass 205.131408 g/mol
D-Panthenol Topological Polar Surface Area 89.8 Ų
D-Panthenol Heavy Atom Count 14
D-Panthenol Formal Charge 0
D-Panthenol Complexity 182
D-Panthenol Isotope Atom Count 0
D-Panthenol Defined Atom Stereocenter Count 1
D-Panthenol Undefined Atom Stereocenter Count 0
D-Panthenol Defined Bond Stereocenter Count 0
D-Panthenol Undefined Bond Stereocenter Count 0
D-Panthenol Covalently-Bonded Unit Count 1
D-Panthenol Compound Is Canonicalized Yes
D-Panthenol is an alcoholic analogue of D-pantothenic acid and cholinergic agent. D-Panthenol acts as a precursor of coenzyme A necessary for acetylation reactions and is involved in the synthesis of acetylcholine. Although the exact mechanism of the actions of D-Panthenol is unclear, it may enhance the effect of acetylcholine. D-Panthenol acts on the gastrointestinal tract and increases lower intestinal motility. It is also applied topically to the skin to relieve itching and to promote healing.D-Panthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. D-Panthenol is enzymatically cleaved to form pantothenic acid, which is an essential component of Coenzyme A, which acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium. Due to its good penetration and high local concentrations, dexpanthanol is used in many topical products, such as ointments and lotions for treatment of dermatological conditions to relieve itching or promote healing. Dermatological effects of the topical use of D-Panthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties. D-Panthenol is also available as a racemic mixture containing both the dextrorotatory form (D-Panthenol) and the levorotatory form (levopanthenol) as [DB11204]. While pantothenic acid is optically active, only the dextrorotatory form (D-Panthenol) is biologically active.D-Panthenol is a monocarboxylic acid amide that is 3,3-dimethylbutanamide substituted by hydroxy groups at positions 2 and 4 and a 3-hydroxypropyl group at the carbomyl nitrogen. It has a role as a cholinergic drug and a provitamin. It is an amino alcohol and a monocarboxylic acid amide.D-Panthenol (topical) relieves itching and aids healing of skin in mild eczemas and dermatoses; itching skin, minor wounds, stings, bites, poison ivy, poison oak (dry sage) and minor skin irritations. Also, used in infants and children for diaper rash, chafing and mild skin irritations.The efficacy of D-Panthenol was comparable to nasal saline irrigation in the postoperative care of sinusitis patients following endoscopic sinus surgery. D-Panthenol is an alternative treatment, which may be useful in young children and complicated cases.D-Panthenol-containing creams have been widely used for treatment of lesions (superficial wounds) of the skin and mucous membranes. D-Panthenol is converted in tissues to pantothenic acid, a component of coenzyme A. … In the present study, the effects were examined of a D-Panthenol-containing cream on skin barrier repair, stratum corneum hydration, skin roughness, and inflammation after sodium lauryl sulphate (SLS)-induced irritation. … Significantly accelerated skin barrier repair was found in treatments with the D-Panthenol-containing cream (verum) compared with vehicle-treated (placebo) or untreated skin. Both verum and placebo showed an increase in stratum corneum hydration, but significantly more so with the D-Panthenol-containing cream. Both creams reduced skin roughness, but again the verum was superior. The D-Panthenol-containing cream significantly reduced skin redness as a sign of inflammation in contrast to the vehicle, which produced no effect.The topical use of D-Panthenol, the stable alcoholic analog of pantothenic acid, is based on good skin penetration and high local concentrations of D-Panthenol when administered in an adequate vehicle, such as water-in-oil emulsions. Topical D-Panthenol acts like a moisturizer, improving stratum corneum hydration, reducing transepidermal water loss and maintaining skin softness and elasticity. Activation of fibroblast proliferation, which is of relevance in wound healing, has been observed both in vitro and in vivo with D-Panthenol. Accelerated re-epithelization in wound healing, monitored by means of the transepidermal water loss as an indicator of the intact epidermal barrier function, has also been seen. D-Panthenol has been shown to have an anti-inflammatory effect on experimental ultraviolet-induced erythema. Beneficial effects of D-Panthenol have been observed in patients who have undergone skin transplantation or scar treatment, or therapy for burn injuries and different dermatoses. The stimulation of epithelization, granulation and mitigation of itching were the most prominent effects of formulations containing D-Panthenol. In double-blind placebo-controlled clinical trials, D-Panthenol was evaluated for its efficacy in improving wound healing. Epidermal wounds treated with D-Panthenol emulsion showed a reduction in erythema, and more elastic and solid tissue regeneration. Monitoring of transepidermal water loss showed a significant acceleration of epidermal regeneration as a result of D-Panthenol therapy, as compared with the vehicle. In an irritation model, pretreatment with D-Panthenol cream resulted in significantly less damage to the stratum corneum barrier, compared with no pretreatment. Adjuvant skin care with D-Panthenol considerably improved the symptoms of skin irritation, such as dryness of the skin, roughness, scaling, pruritus, erythema, erosion/fissures, over 3 to 4 weeks. Usually, the topical administration of D-Panthenol preparations is well tolerated, with minimal risk of skin irritancy or sensitization.D-Panthenol is popular in treating various dermatoses and in skin care, but few controlled clinical trials have been performed. … 25 healthy volunteers (age 18-45 years) were treated for the inner aspect of both forearms with either Bepanthol Handbalsam containing 5% D-Panthenol or placebo x2 daily for 26 days. From day 15-22, sodium lauryl sulfate (SLS) 2% was applied to these areas x2 daily. Documentation comprised sebumetry, corneometry, pH value and clinical appearance (photographs). 21 volunteers completed the study, 3 were excluded because of non-compliance and 1 experienced a non-study-related, severe, adverse event. Only corneometry yielded a statistically significant difference, with decreased values following SLS challenge at the placebo sites (P < 0.05). Intraindividual comparisons showed superior results at the D-Panthenol-treated sites in 11 cases and in only 1 case at the placebo site. 6 volunteers experienced an irritant contact dermatitis, with more severe symptoms at the placebo site in 5 cases.In a randomized, double-blind, placebo-controlled study the effect of topical D-Panthenol formulated in two different lipophilic vehicles on epidermal barrier function in vivo was carried out. Seven days’ treatment with D-Panthenol improved stratum corneum hydration and reduced transepidermal water loss. Active treatment was statistically different from the vehicle control on both measures.The aim of the current study is to compare the tolerability of a preservative-free D-Panthenol (5%) nasal spray with that of the established D-Panthenol (5%) nasal ointment, also without preservatives. The main outcome measure was in vivo mucociliary clearance. METHOD: Mucociliary clearance was assessed by saccharin migration time in 20 volunteers. … D-Panthenol nasal spray is at least equal to if not better than D-Panthenol nasal ointment.One case of heartburn and a few cases of GI cramps have been reported after D-Panthenol administration. Allergic reactions to D-Panthenol have been reported occasionally; however, these reactions have not been directly attributed to the drug. Although isolated reports of itching, tingling, difficulty in breathing, erythema, generalized dermatitis, urticaria, temporary respiratory difficulty (when D-Panthenol injection was administered 5 minutes after succinylcholine had been discontinued), hypotension, persistent (up to 10 days) diarrhea, and agitation have been associated with use of D-Panthenol injection, a causal relationship to the drug has not been established.D-Panthenol is an alcoholic analogue of D-pantothenic acid and cholinergic agent. D-Panthenol acts as a precursor of coenzyme A necessary for acetylation reactions and is involved in the synthesis of acetylcholine. Although the exact mechanism of the actions of D-Panthenol is unclear, it may enhance the effect of acetylcholine. D-Panthenol acts on the gastrointestinal tract and increases lower intestinal motility. It is also applied topically to the skin to relieve itching and to promote healing.D-Panthenol is soluble in water and alcohol, although insoluble in fats and oil based substances. With the appropriate vehicle, D-Panthenol is easily penetrated into the skin. Rate of penetration and absorption is reduced when D-Panthenol is administered as an oil/water formula.D-Panthenol is readily converted to pantothenic acid which is widely distributed into body tissues, mainly as coenzyme A.D-Panthenol is converted to pantothenic acid … which then produces acetylcholine.D-Panthenol injection should be protected from freezing & excessive heat.D-Panthenol is incompatible with alkalis & strong acids.In a patient with contact dermatitis, D-Panthenol was found to be the causative allergen. There was a positive reaction to D-Panthenol on patch testing. Controls did not show any positive reactions to D-Panthenol on patch testing.Eleven cases of contact allergy to D-Panthenol are reported (5 females, 6 males; mean age 62.4 years). Five patients suffered from a leg ulcer and/or stasis dermatitis. In five patients the sensitization occurred after the application of D-Panthenol-containing ointments to the face. Only one patient did not show sensitization to other common allergens.
TR
D-Panthenol IUPAC Ad (2R) -2,4-dihidroksi-N- (3-hidroksipropil) -3,3-dimetilbutanamid
D-Panthenol InChI 1S / C9H19NO4 / c1-9 (2,6-12) 7 (13) 8 (14) 10-4-3-5-11 / h7,11-13H, 3-6H2,1-2H3, (H, 10,14) / t7- / m0 / s1
D-Panthenol InChI Anahtar SNPLKNRPJHDVJA-ZETCQYMHSA-N
D-Panthenol Kanonik SMILES CC (C) (CO) C (C (= O) NCCCO) O
D-Panthenol zomerik SMILES CC (C) (CO) [C @ H] (C (= O) NCCCO) O
D-Panthenol Moleküler Formül C9H19NO4
D-Panthenol CAS 81-13-0
D-Panthenol Kullanmdan Kaldrlm CAS 1113-70-8, 17307-32-3, 50584-68-4
D-Panthenol Avrupa Topluluu (EC) Numaras 201-327-3
D-Panthenol UNII 1O6C93RI7Z
D-Panthenol DSSTox Madde Kimlii DTXSID3022906
D-Panthenol Fiziksel Tanm Kat
D-Panthenol Color / Form Higroskopik ya
D-Panthenol Tad Hafif ac tad
D-Panthenol Kaynama Noktas Ayrr
D-Panthenol Erime Noktas <25 ° C
D-Panthenol Çözünürlüü 4.87 M
20 ° C’de D-Panthenol Younluu 1.2
25 ° C’de D-Panthenol Buhar Basnc 1.5X10-8 mm Hg (tahmini)
D-Panthenol LogP log Kow = -1,92 (tahmini)
D-Panthenol Stabilite / Raf Ömrü Olaan sterilizasyon süresine makul ölçüde stabildir ve sulu çözelti içinde pH 3.0-4.0’da scaklk; uzun stma rasemizasyona neden olur.
D-Panthenol Optik Dönü Özel optik rotasyon: 20 ° C / D’de +29,5 derece (su,% 5)
D-Panthenol Ayrmas Ayrmaya kadar stldnda / nitrik oksit / zehirli dumanlar yayar.
D-Panthenol pH pH 9.5
D-Panthenol Krlma ndeksi Krlma ndeksi: 20 ° C / D’de 1.497
D-Panthenol Çarpma Kesiti 144.7 Ų [M + H] +
D-Panthenol Molekül Arl 205.25 g / mol
D-Panthenol XLogP3-AA -0.9
D-Panthenol Hidrojen Ba Donör Says 4
D-Panthenol Hidrojen Ba Alc Says 4
D-Panthenol Dönebilen Bond Says 6
D-Panthenol Tam Kütle 205.131408 g / mol
D-Panthenol Monoizotopik Kütle 205.131408 g / mol
D-Panthenol Topolojik Polar Yüzey Alan 89,8 Ų
D-Panthenol Ar Atom Says 14
D-Panthenol Resmi Yükü 0
D-Panthenol Karmakl 182
D-Panthenol zotop Atom Says 0
D-Panthenol Tanml Atom Stereocenter Says 1
D-Panthenol Tanmsz Atom Stereocenter Says 0
D-Panthenol Tanml Bond Stereocenter Says 0
D-Panthenol Tanmsz Ba Stereocenter Says 0
D-Panthenol Kovalent Bal Birim Says 1
D-Panthenol Bileii Kanonikletirilmitir Evet
D-Panthenol, D-pantotenik asit ve kolinerjik ajann alkollü bir analoudur. D-Panthenol, asetilasyon reaksiyonlar için gerekli olan koenzim A’nn öncüsü olarak görev yapar ve asetilkolin sentezinde rol oynar. D-Panthenol’ün etki mekanizmas tam olarak bilinmemekle birlikte, asetilkolinin etkisini artrabilir. D-Panthenol gastrointestinal sisteme etki eder ve barsak hareketliliini azaltr. Ayrca kanty hafifletmek ve iyilemeyi desteklemek için cilde topikal olarak uygulanr. D-Panthenol, pantotenik asidin bir alkol türevi, B kompleks vitaminlerinin bir bileeni ve normal ileyen bir epitelin temel bir bileenidir. D-Panthenol, epitelde protein metabolizmas için önemli olan birçok enzimatik reaksiyonda bir kofaktör görevi gören Koenzim A’nn temel bir bileeni olan pantotenik asidi oluturmak üzere enzimatik olarak parçalanr. yi penetrasyonu ve yüksek lokal konsantrasyonlar nedeniyle dekspantanol, kanty hafifletmek veya iyilemeyi desteklemek için dermatolojik durumlarn tedavisi için merhemler ve losyonlar gibi birçok topikal üründe kullanlr. D-Panthenol’ün topikal kullanmnn dermatolojik etkileri arasnda artan fibroblast proliferasyonu ve yara iyilemesinde hzlandrlm yeniden epitelizasyon yer alr. Ayrca, topikal bir koruyucu, nemlendirici görevi görür ve anti-inflamatuar özellikler göstermitir. D-Panthenol, hem dekstrorotatör formu (D-Panthenol) hem de levorotatori formu (levopanthenol) [DB11204] olarak içeren rasemik bir karm olarak da mevcuttur. Pantotenik asit optik olarak aktifken, sadece dekstrorotator form (D-Panthenol) biyolojik olarak aktiftir. D-Panthenol, 3,3-dimetilbutanamid, 2 ve 4 pozisyonlarnda hidroksi gruplar ve bir 3-hidroksipropil grubu ile ikame edilen bir monokarboksilik asit amididir. karbomil nitrojende. Kolinerjik bir ilaç ve provitamin olarak rol oynar. Bir amino alkol ve bir monokarboksilik asit amiddir. D-Panthenol (topikal) kanty giderir ve hafif egzama ve dermatozlarda cildin iyilemesine yardmc olur; kant, küçük yaralar, sokmalar, srklar, zehirli sarmak, zehirli mee (kuru adaçay) ve küçük cilt tahrileri. Ayrca bebeklerde ve çocuklarda piik, sürtünme ve hafif cilt tahrileri için kullanlr. D-Panthenol’ün etkinlii, endoskopik sinüs cerrahisini takiben sinüzit hastalarnn postoperatif bakmnda nazal salin irrigasyonu ile karlatrlabilir düzeydedir. D-Panthenol, küçük çocuklarda ve komplike vakalarda faydal olabilecek alternatif bir tedavidir. D-Panthenol içeren kremler, cilt lezyonlarnn (yüzeysel yaralarn) ve mukoza zarlarnn tedavisinde yaygn olarak kullanlmaktadr. D-Panthenol, dokularda koenzim A’nn bir bileeni olan pantotenik aside dönütürülür … Bu çalmada, D-Panthenol içeren bir kremin cilt bariyeri onarm, stratum corneum hidrasyonu, skler üzerindeki etkileri incelenmitir.sodyum lauril sülfat (SLS) kaynakl tahriten sonra pürüzlülük ve iltihaplanma. … Araçla tedavi edilmi (plasebo) veya tedavi edilmemi cilde kyasla D-Panthenol içeren krem (verum) ile yaplan tedavilerde önemli ölçüde hzlandrlm cilt bariyeri onarm bulundu. Hem verum hem de plasebo, stratum corneum hidrasyonunda bir art gösterdi, ancak D-Panthenol içeren kremde önemli ölçüde daha fazla. Her iki krem de cilt pürüzlülüünü azaltt ancak yine verum üstündü. D-Panthenol içeren krem, hiçbir etki yaratmayan aracn aksine, iltihap belirtisi olarak cilt kzarkln önemli ölçüde azaltmtr. Pantotenik asidin stabil alkol analou olan D-Panthenol’ün topikal kullanm, iyi cilt penetrasyonuna dayanmaktadr ve Yada su emülsiyonlar gibi uygun bir araç içinde uygulandnda yüksek lokal D-Panthenol konsantrasyonlar. Topikal D-Panthenol nemlendirici gibi davranr, stratum corneum hidrasyonunu iyiletirir, transepidermal su kaybn azaltr ve cildin yumuakln ve elastikiyetini korur. Yara iyilemesi ile ilgili olan fibroblast proliferasyonunun aktivasyonu, D-Panthenol ile hem in vitro hem de in vivo gözlenmitir. Salam epidermal bariyer fonksiyonunun bir göstergesi olarak transepidermal su kayb ile izlenen yara iyilemesinde hzlanan yeniden epitelizasyon da görülmütür. D-Panthenol’ün deneysel ultraviyole kaynakl eritem üzerinde anti-enflamatuar bir etkiye sahip olduu gösterilmitir. Deri nakli veya yara izi tedavisi veya yank yaralanmalar ve farkl dermatozlar için tedavi gören hastalarda D-Panthenol’ün faydal etkileri gözlenmitir. Epitelizasyonun uyarlmas, granülasyon ve kanmann hafifletilmesi, D-Panthenol içeren formülasyonlarn en belirgin etkileriydi. Çift kör, plasebo kontrollü klinik çalmalarda, D-Panthenol, yara iyilemesini iyiletirmedeki etkinlii açsndan deerlendirildi. D-Panthenol emülsiyonu ile tedavi edilen epidermal yaralar, eritemde bir azalma ve daha elastik ve kat doku yenilenmesi gösterdi. Transepidermal su kaybnn izlenmesi, araçla karlatrldnda D-Panthenol tedavisinin bir sonucu olarak epidermal rejenerasyonda önemli bir hzlanma gösterdi. Bir tahri modelinde, D-Panthenol kremi ile ön muamele, ön muameleye kyasla, stratum korneum bariyerine önemli ölçüde daha az hasar vermitir. D-Panthenol ile adjuvan cilt bakm, ciltte kuruluk, pürüzlülük, pullanma, kant, eritem, erozyon / çatlaklar gibi cilt tahriinin semptomlarn 3 ila 4 hafta boyunca önemli ölçüde iyiletirmitir. Genellikle, D-Panthenol preparatlarnn topikal uygulamas, minimum cilt tahrii veya hassaslama riski ile iyi tolere edilir. D-Panthenol, çeitli dermatozlarn tedavisinde ve cilt bakmnda popülerdir, ancak birkaç kontrollü klinik çalma yaplmtr. … 25 salkl gönüllü (18-45 ya) her iki ön kolun iç taraf için% 5 D-Panthenol içeren Bepanthol Handbalsam veya plasebo x2 ile 26 gün boyunca tedavi edildi. 15-22. Günden itibaren, bu alanlara günlük% 2 sodyum lauril sülfat (SLS) uyguland. Belgeler sebumetri, korneometri, pH deeri ve klinik görünümü (fotoraflar) içeriyordu. 21 gönüllü çalmay tamamlad, 3’ü uyumsuzluk nedeniyle dland ve 1’i çalmayla ilgili olmayan, ciddi, olumsuz bir olay yaad. Yalnzca korneometri, plasebo bölgelerinde SLS tehdidini takiben azalm deerler ile istatistiksel olarak anlaml bir fark verdi (P <0.05). Bireyler aras karlatrmalar, D-Panthenol ile tedavi edilen bölgelerde 11 vakada ve plasebo bölgesinde sadece 1 vakada üstün sonuçlar gösterdi. 6 gönüllü, 5 vakada plasebo bölgesinde daha iddetli semptomlarla birlikte tahri edici bir kontakt dermatit yaamtr. vivo gerçekletirildi. D-Panthenol ile yedi günlük tedavi, stratum corneum hidrasyonunu iyiletirdi ve transepidermal su kaybn azaltt. Aktif tedavi, her iki önlemde de araç kontrolünden istatistiksel olarak farklyd. Bu çalmann amac, koruyucu içermeyen bir D-Panthenol (% 5) burun spreyinin tolere edilebilirliini, yerleik D-Panthenol (% 5) ile karlatrmaktr. nazal merhem, ayrca koruyucu madde içermez. Ana sonuç ölçüsü, in vivo mukosiliyer klirens idi. YÖNTEM: Mukosiliyer klirens 20 gönüllüde sakarin migrasyon süresi ile deerlendirildi. … D-Panthenol burun spreyi, en azndan D-Panthenol nazal merhemden daha iyi deilse de eittir. D-Panthenol uygulamasndan sonra bir mide ekimesi vakas ve birkaç GI kramp vakas bildirilmitir. D-Panthenol’e kar alerjik reaksiyonlar zaman zaman bildirilmitir; ancak, bu reaksiyonlar dorudan ilaca atfedilmemitir. Kant, karncalanma, nefes almada zorluk, eritem, jeneralize dermatit, ürtiker, geçici solunum güçlüü (D-Panthenol enjeksiyonu 5 dakika uygulandnda) ile ilgili izole raporlar olmasna ramenSüksinilkolin kesildikten sonra), hipotansiyon, kalc (10 güne kadar) diyare ve ajitasyon, D-Panthenol enjeksiyonunun kullanm ile ilikilendirildiinde, ilaçla nedensel bir iliki kurulmamtr. D-Panthenol, alkollü bir analogdur. D-pantotenik asit ve kolinerjik ajan. D-Panthenol, asetilasyon reaksiyonlar için gerekli olan koenzim A’nn öncüsü olarak görev yapar ve asetilkolin sentezinde rol oynar. D-Panthenol’ün etki mekanizmas tam olarak bilinmemekle birlikte, asetilkolinin etkisini artrabilir. D-Panthenol gastrointestinal sisteme etki eder ve barsak hareketliliini azaltr. Ayrca kanty gidermek ve iyilemeyi desteklemek için cilde topikal olarak uygulanr. D-Panthenol, yalarda ve ya bazl maddelerde çözünmese de suda ve alkolde çözünür. Uygun araçla D-Panthenol cilde kolayca nüfuz eder. D-Panthenol bir ya / su formülü olarak uygulandnda penetrasyon ve absorpsiyon hz azalr. D-Panthenol, vücut dokularna yaygn olarak dalan pantotenik aside dönütürülür, esas olarak koenzim AD-Panthenol’ün pantotenik aside dönütürülmesi gibi. Daha sonra asetilkolin üreten D-Panthenol enjeksiyonu donma ve ar sdan korunmaldr. D-Panthenol, alkaliler ve güçlü asitlerle uyumsuzdur. Kontakt dermatitli bir hastada D-Panthenol’ün nedensel alerjen olduu bulunmutur. Yama testinde D-Panthenol’e pozitif reaksiyon oldu. Kontroller yama testinde D-Panthenol’e herhangi bir pozitif reaksiyon göstermemitir. D-Panthenol’e kar on bir temas alerjisi vakas bildirilmitir (5 kadn, 6 erkek; ortalama ya 62,4). Be hasta, bacak ülseri ve / veya staz dermatitinden muzdaripti. Be hastada hassasiyet, D-Panthenol içeren merhemlerin yüze uygulanmasndan sonra meydana geldi. Yalnzca bir hasta dier yaygn alerjenlere duyarllk göstermedi.