DECYL OLEATE
SYNONYMS:
Decyl oleate; Decyl 9-octadecenoate; Oleic acid, decyl ester; UNII-ZGR06DO97T; 9-Octadecenoic acid, decyl ester; 9-Octadecenoic acid (Z)-, decyl ester; 9-Octadecenoic acid (9Z)-, decyl ester; decyl (9Z)-octadec-9-enoate; n-decyl oleate; Schercemol DO; Tegosoft DO; Cetiol V; decanol oleate ester; EINECS 222-981-6; Ceraphyl 140; AC1NSHAP; EC 222-981-6; SCHEMBL15078; decyl (Z)-octadec-9-enoate; 1-O-decyl-(9Z)-octadecenoate; Decyl (9Z)-9-octadecenoate #; DTXSID1029259; CHEBI:75620; desil oleat; DESL OLEAT; DESYL OLEAT; DESIL OLEATE; DESL OLEAT; DESIL OLEATE; desyl oleate; oleate; oleat; desil; decyl; DECYL; OLEATE DECYL; Decyloleat;DECYL OLEATE;Decyl Oleate DO;Decyl9-octadecanoate;Oleic acid decyl ester;9-OCTADECENOICACID(Z)-; DECYLESTER;(Z)-9-; Octadecenoic acid decyl ester; (9Z)-9-Octadecenoic acid decyl ester; 9-Octadecenoic acid (9Z)-; decyl ester
Decyl9-octadecanoate; DECYL OLEATE9-Octadecenoic acid; (9Z)-; decyl ester9-OCTADECENOICACID(Z)-; DECYLESTERDecyloleat; (9Z)-9-Octadecenoic acid; decyl ester(Z)-9-Octadecenoic acid decyl; esterOleic acid; decyl esterDecyl; Oleate DO3687; -46-5C28H54O2; Decyl oleate; Decyl 9-octadecenoate; Oleic acid, decyl ester; UNII-ZGR06DO97T; 9-Octadecenoic acid, decyl ester; 9-Octadecenoic acid (Z)-, decyl ester; 9-Octadecenoic acid (9Z)-, decyl ester; decyl (9Z)-octadec-9-enoate; n-decyl oleate; Schercemol DO; Tegosoft DO; Cetiol V; decanol oleate ester; EINECS 222-981-6; Ceraphyl 140; AC1NSHAP; EC 222-981-6; SCHEMBL15078; decyl (Z)-octadec-9-enoate; 1-O-decyl-(9Z)-octadecenoate; Decyl (9Z)-9-octadecenoate #; DTXSID1029259; CHEBI:75620; desil oleat; DESL OLEAT; DESYL OLEAT; DESIL OLEATE; DESL OLEAT; DESIL OLEATE; desyl oleate; oleate; oleat; desil; decyl; DECYL; OLEATE DECYL; Decyloleat;DECYL OLEATE;Decyl Oleate DO;Decyl9-octadecanoate;Oleic acid decyl ester;9-OCTADECENOICACID(Z)-; DECYLESTER;(Z)-9-; Octadecenoic;acid decyl ester; (9Z)-9-Octadecenoic acid decyl ester; 9-Octadecenoic acid (9Z)-; decyl ester; Decyl9-octadecanoate; DECYL OLEATE9-Octadecenoic acid; (9Z)-; decyl ester9-OCTADECENOICACID(Z)-; DECYLESTERDecyloleat; (9Z)-9-Octadecenoic acid; decyl ester(Z)-9-Octadecenoic acid decyl; esterOleic acid; decyl esterDecyl; Oleate DO3687; -46-5C28H54O2; DECYL OLEATE; Decyloleat; (9Z)-9-Octadecenoic acid decyl ester; 9-OCTADECENOICACID(Z)-; desilester; DESL ESTER; DECYLESTER; (Z)-9-Octadecenoic acid decyl ester; Decyl Oleate D; 9-Octadecenoic acid (9Z)-,decyl ester; Cetiol.(R). V; Oleic acid decyl ester; Decyl9-octadecanoate; DECYL OLEATE is classified as : decyl (9Z)-9-octadecenoate; decyl (9Z)-octadec-9-enoate; decyl (Z)-octadec-9-enoate; decyl 9-octadecenoate; 9-octadecenoic acid (9Z)-, decyl ester; 9-octadecenoic acid (Z)-, decyl ester; (Z)-9-octadecenoic acid decyl ester ; 9-octadecenoic acid decyl ester; 9-octadecenoic acid, decyl ester; 9-octadecenoic acid, decyl ester, (9Z)-; oleic acid, decyl ester
CAS Number 3687-46-5
EINECS/ELINCS No: 222-981-6
COSING REF No: 75506
Chem/IUPAC Name: Decyl oleate
What Is Decyl Oleate ?
Decyl Oleate and Isodecyl Oleate are made from decyl alcohol and oleic acid. Decyl Oleate is made from straight chained decyl alcohol, while Isodecyl Oleate is made from branched chain decyl alcohol. Decyl Oleate and Isodecyl Oleate are used in a variety of cosmetics and personal care products, including makeup, and skin and hair care products.
Why is Decyl Oleate used in cosmetics and personal care products?
Decyl Oleate and Isodecyl Oleate act as lubricants on the skin surface, which gives the skin a soft and smooth appearance. These ingredients also form a thin film on the skin that is neither greasy nor tacky. The unique properties of Decyl Oleate and Isodecyl Oleate facilitate the application and removal of makeup.Decyl oleate
* Made from the naturally occurring fatty acid, oleic acid.
Primarily used as a lubricant.Emollient, Skin conditioning It creates a thin, non-greasy film that gives the skin a smooth and soft appearance. It’s frequently used used in products geared at removing makeup. You can find this ingredient in cosmetics such as facial moisturizer/lotion, anti-aging treatment, sunscreen, eye shadow, hand & foot cream, conditioner, aftershave and eye cream.Functions:
Primarily used as a lubricant. It creates a thin, non-greasy film that gives the skin a smooth and soft appearance. It’s frequently used used in products geared at removing makeup. You can find this ingredient in cosmetics such as facial moisturizer/lotion, anti-aging treatment, sunscreen, eye shadow, hand & foot cream, conditioner, aftershave and eye cream.
Safety Measures/Side Effects:
The Cosmetic Ingredient Review (CIR) Expert Panel has assessed this ingredient as non-toxic and non-irritating, thus determining it as safe to use in cosmetic products. It has been shown to be comedogenic (clog the pores), and should be avoided by those with oily and acne prone skin types.Decyl Oleate and lsodecyl Oleate are esters of oleic acid. Decyl Oleate is used
in cosmetic products at concentrations ranging from I 0.1 to > 50%. Isodecyl
Oleate is used at concentrations of > 0.1-25%.
Animal studies have shown both Decyl Oleate and lsodecyl Oleate to
possess low acute oral toxicities in rats with LD50s of > 40 ml/kg, Single application dermal and eye studies with rabbits have shown these materials at
100% concentrations produce little or no irritation. Daily applications of 159b
or 100% concentrations for 60 days to the skin of rabbits produced a moderate
degree of irritation with both Decyl and lsodecyl Oleate. Neither of the ingredients was found to be a sensitizer when tested in guinea pigs at concentrations
of 15%.
Repeated insult patch tests containing 1-5’1’0 Decyl Oleate showed no
signs of sensitization. Testing with formulations containing 5.5% Decyl Oleate
produced a low number of reactions in 402 human subjects in the SchwartzPeck Prophetic Patch Test and 204 subjects with undiluted lsodecyl Oleate on
nine subjects showed a total irritation score of 1 .O out of a maximum of 756.
It is concluded that, because of both the chemical similarity of these compounds and the similarity of the available animal and human data, Decyl and
lsodecyl Oleates warrant a conclusion of safe in the concentrations of present
practices and use in cosmetics. ecyl Oleate and lsodecyl Oleate are esters of oleic acid. Formed by ester- D ification of oleic acid with decyl or isodecyl alcohol, they have the following
structural formulas:
Decyl Oleate-
lsodecyl Oleate- CH3 (CH CH=CH(CH2) 7COOCH2 (CH2) 6CH (CH3) 27
Methyl Oleate is a compound chemically related to Decyl Oleate and
lsodecyl Oleate. Its structural formula is as follows:
CH3 (CH2) 7CH=CH (CH2) 7COOCH 3
The safety of methyl oleate is not under review in this report. Information and
data pertaining to this compound are included to permit a more complete appraisal of the safety of Decyl Oleate and lsodecyl Oleate.Some of the chemical and physical properties of these esters are given in
Reactivity
Unsaturated fatty acids and their esters readily undergo aut~xidation.’~)
Methyl oleate can serve as a model for autoxidation reactions which all the oleic
acid esters exhibited. This compound undergoes autoxidation to give primarily
trans-hydro peroxide^,’^) which are highly unstable and readily decompose to
keto and hydroxy keto acids.(6) Some hydroperoxides have been found to
possess carcinogenic potential.”) Methyl oleate undergoes photochemical
decomposition in direct sunlight and in the presence of oxygen to form the
ozonide of methyl oleic acid.(*) The most important secondary products of
autoxidation include alpha, beta-u nsatu rated carbonyl com pou nds.(5) Hemati n
com pou nds, (‘) metals, (lo) and chlorinated hydrocarbon i nsecticides’ “) accelerate the autoxidation reaction by shortening the induction period.
Analytical Methods
Methyl oleate can be generated in purities of 98% or better by repeated
distillation with urea at a low temperature.(‘2) Analysis of this and related compounds is done by gas-liquid or thin-layer chromatography. The position of the
double bond can be determined by von Rudolph’s oxidation procedure. Infrared
spectroscopy can be used to delineate cis-trans i~omers.(‘~-~~)
Although gas-liquid chromatography remains the preferred routine analytical method for fatty acid ester mixtures, utilization of high performance liquid
chromatography (HPLC) is increasing; for the latter has the advantage of identifying polymerized and oxidized esters which the former does not dete.
PURPOSE AND FREQUENCY OF USE IN COSMETICS
Decyl and lsodecyl Oleates have been widely used in cosmetic products. When applied to the skin alone, they deposit a thin oily film that is neither greasy nor tacky. They have good lubrication properties and possess low viscosity.(“) Both materials are used as dispersants and lubricants in cosmetic formulations,
and these are particularly important in makeup and makeup removers, in which they are used as wetting agents for iron oxide pigments; particles of such pigment are dispersed and easily suspended. The use of these ingredients facilities the application and removal of a suspension.
By virtue of its branched chain structure, lsodecyl Oleate possesses several distinct properties. It has the ability to lower the freezing point of the emulsion
phase of products, as well as to control product viscosity. In dispersible bath oils, it forms a white emulsion, giving the tub water a rich and milky appearance. It also has the ability to suspend aluminum chlorohydrate, which makes it valuable for dry antiperspirant formulations. Lipstick formulations have employed lsodecyl Oleate because its coupling properties increase the hardness and strength of the product without reducing its flow characteristics.
Table 2 indicates categories of product use and concentrations of use for Decyl and lsodecyl Oleate.(‘*) The cosmetic product formulation computer printout which is made available by the Food and Drug Administration (FDA) is compiled through voluntary filing of such data in accordance with Title 21 Part 720.4
of the Code of Federal Regulations (1979). Ingredients are listed in prescribed concentration ranges under specific product type categories. Since certain cosmetic ingredients are supplied by the manufacturer at less that 100% concentration, the value reported by the cosmetic formulator may not necessarily reflect
the true, effective concentration found in the finished product; the effective concentration in such a case would be a fraction of that reported to the FDA. The fact that data are only submitted within the framework of preset concentration ranges also provides the opportunity for overestimation of the actual concentration of an ingredient in a particular product. An entry at the lowest end of a concentration range is considered the same as one entered at the highest end of that range,
thus introducing the possibility of a two- to ten-fold error in the assumed ingredient concentration. The compounds are employed in a variety of cosmetics, including makeup preparations, skin care preparations, and eye-shadow. Concentrations of use range from 50.1 to > for Decyl Oleate and > 0.1-25% for
I sod ec y I 0 leate. Products containing these two materials are applied with varying frequency to all areas of the skin. In such formulations as blushers and moisturizing creams, exposure may occur several times a day, while in other cases there may be daily
(deodorants) or less frequent (rinses, hair conditioners) applications. This occasional or daily use may extend over a period of years.
Animal Toxicology
Decyl Oleate: This ingredient was administered to Wistar rats by intragastric intubation at dose levels of 2.5, 5.0, 10.0, 20.0, and 40.0 mllkg COSMETIC INGREDIENT REVIEW
two female rats per dose The animals were fasted for 24 hours prior to dosing. All animals were observed daily for 14 days following administration and no deaths were recorded. The acute LD50 of undiluted Decyl Oleate was greater than 40.0 mllkg of body weight. Wistar-derived rats (groups of five male, five female) were dosed by gavage with either 5.0 glkg of undiluted Decyl Oleate or 5.0 glkg of 20 percent Decyl
Oleate, 80% mineral The rats were fasted for 18 hours prior to dosing. The animals were observed for signs of pharmacologic activity and drug toxicity at 1, 3, 6, and 24 hours post-dosing, after which daily observations were made for a
total of 14 days. One death was recorded for male animals in the diluted sample group, and one female died following treatment with the undiluted sample. No treatment-related effects were noted in any of the surviving animals. Examination of tissues of nons,urvivors and survivors at gross autopsy revealed no abnormalities.
lsodecyl Oleate: This ingredient was administered to Wistar rats by intragastric intubation at dose levels of 2.5, 5.0, 10.0, 20.0, and 40.0 mllkg (two female and three male rats per dose The animals were fasted for 24
hours prior to dosing. One death was recorded at the highest dose level. The acute LD50 of undiluted Isodecyl Oleate was reported to be greater than 40.0 ml/kg of body weight.
Dermal irritation
Decyl Oleate: Drai~e’~~) and Federal Hazardous Substances Labeling Act(22) (FHSA) methods were used to conduct primary skin irritation studies. Test samples of Decyl Oleate (undiluted, 10 percent in corn oil and 20% in mineral
oil) were applied (0.5 ml) to clipped areas of intact and abraded albino rabbits skin (six animals in each group). The abrasions were longitudinal, epidermal incisions sufficiently deep to penetrate the stratum corneum, but not so deep as to disturb the dermis. Following application of the test material, the exposed area
was covered with a patch and the entire experimental area was sealed with impervious sheeting. The animals were immobilized for a 24-hour period. The mean scores for 24- and 72-hour gradings were averaged to determine final irritation values. The primary irritation index (PII) for undiluted Decyl Oleate was calculated to be 0.28.L25) Itwas also determined that Decyl Oleate had primary irritation indices of 0.08 as a 10 percent solution in corn oil(22) and 0.05 as a 20% solution in mineral
A modified Draize method was used to conduct primary dermal irritation studies with undiluted and 15% Decyl Oleate diluted in polyoxyethylene sorbitan stearate (3%), a perservative (2%)) and water; the material was found to be nonirritating (Table 3).(“j)
lsodecyl Oleate: This ingredient (0.5 ml) was applied undiluted to the clipped
intact and abraded skin of three albino rabbits. The patch area was covered with
Webril patches, and the entire experimental area was sealed with Blenderm
Surgical Tape. After the animals had remained in restraining stocks for 24 hours,
the patches were removed and the treated skin evaluated according to the
method of Draize. The skin was evaluated again 72 hours later and the primary irritation index was calculated. The lsodecyl Oleate was calculated to have a PI1 of
1 .OO in this e~periment.’~~) In a summary report it was determined that undiluted
lsodecyl Oleate applied to the skin of rabbits had a primary irritation index of
Decyl Oleate: Decyl Oleate was applied daily for eight weeks to the skin of
rabbits; the FHSA method was used with slight modifications. Undiluted or 15%
Decyl Oleate diluted in polyoxyethylene sorbitan stearate (3%), a preservative
(2%), and water were used. Reactions were evaluated daily, and at the end of the
eight-week period, two skin samples were examined histologically. The compound produced irritation at the 15% and 100% levels (Table 5). Following a
seven-day rest period, a challenge patch was applied to determine whether observed reactions were allergic or irritant in origin; the results indicated that they
were the latter.(26)
The Landsteiner and Jacobs guinea pig sensitization procedure was utilized
to evaluate Decyl Oleate at a 15% solution in corn oil.(28) Hair on the backs of 10 white male guinea pigs weighing 300-500 g each was clipped prior to the study’s
initiation and whenever it was subsequently necessary. A 0.1% solution of the Decyl Oleate was intracutaneously injected three times a week into the shaved back areas of the animals. These injections, which continued until a total of 10
had been made, consisted of 0.05 ml of test solution for the first injection and 0.1 ml for the remaining nine. Two weeks after the tenth injection, a challenge injection of 0.05 ml of freshly prepared solution was made just below the region of the sensitizing injections. The control, corn oil (0.1 %) in physiological saline, was
given in the same amount as the test material. Twenty-four hours following injection, scorings were recorded for the diameter, height, and redness of any reactions, and the average scores for the 10 sensitizing injections were compared with the scores for challenge injections. If the challenge score is substantially higher than the average value, sensitization would be reported. Because Decyl Oleate failed, upon challenge, to exhibit higher values, it is considered to be a nonsensitizer (its score was 0.0).
Clinical Assessment of Safety
Decyl Oleate: A human repeated insult patch test was conducted on 103
subjects with a skin conditioner containing 1-5% Decyl Oleate. Patches containing approximately 0.2 ml of undiluted sample were applied on Monday, Wednesday, and Friday for three consecutive weeks. Fourteen days after the final insult
patch, challenge patches containing the undiluted skin conditioner were applied, and results were graded 48 and 96 hours later. No evidence of sensitization was found; no information on irritation potential was
Four formulations of a foundation containing Decyl Oleate (5.5%) were
tested in the Schwartz-Peck Prophetic Patch Test and the Draize-Shelanski Repeated Insult Patch Test. “Virtually zero reactions occurred in 402 subjects in the
Schwartz-Peck Test and 204 subjects in the Draize-Shelanski Test.”(23)
lsodecyl Oleate: A single insult (24-hour) occlusive patch test was conducted
on 19 human subjects with undiluted lsodecyl Oleate. The test material did not
elicit any erythematous reactions. A summary report of the study concluded that
Isodecyl Oleate exhibits an acceptably low incidence of primary skin irritation
under occlusive patch test
According to an industry raw material evaluation, a procedure was undertaken with lsodecyl Oleate under the conditions of a Maibach-type Cumulative
lrritancy Assay. When lsodecyl Oleate was applied undiluted under patch conditions to the skin of nine subjects for 21 consecutive days, it was found to have a
total irritation score of 1 .O out of a maximum possible 756.(30)
SUMMARY
Decyl Oleate and lsodecyl Oleate are esters of oleic acid. Decyl Oleate is
used in cosmetic products at concentrations ranging from 10.1 to >50°/o.
lsodecyl Oleate is used at concentrations of > 0.1 -25%.
Animal studies have shown Decyl Oleate and lsodecyl Oleate to possess low
acute oral toxicities in rats; both have LD50s of > 40 mllkg. Single application
dermal and eye studies with rabbits have shown that these materials in concentrations up to 100% produce little or no irritation. When 15% or 100°/o concentrations were applied to the skin of rabbits daily for 60 days, both Decyl Oleate
and lsodecyl Oleate produced moderate degrees of irritation. Neither ingredient was found to be a sensitizer when it was tested in guinea pigs at concentrations of 15%.
Repeated human insult patch tests on 103 subjects with a skin conditioner
containing 1-5% Decyl Oleate showed no signs of sensitization. Industrial testing
with formulations containing 5.5% Decyl Oleate produced a low number of
reactions in 402 human subjects in the Schwartz-Peck Prophetic Patch Test and
in 204 subjects in the Draize-Shelanski Patch Test. Repeated insult patch tests
with undiluted Isodecyl Oleate on an unspecified number of human subjects
showed a total irritation score of 1 .O out of a possible maximum of 756. A single
insult occlusive patch test on 19 human subjects with undiluted lsodecyl Oleate
produced a low level of primary skin irritation.
No chronic, oral subchronic, carcinogenicity, mutagenicity, or teratogenicity
animal testing data were available to the Panel. Nor were there any phototoxicity
or photosensitization studies in humans.
Decyl Oleat Nedir?
Decyl Oleat ve Isodecyl Oleat, desil alkol ve oleik asitten yaplr. Desil Oleat düz zincirli desil alkolden yaplrken Isodecyl Oleate dall zincirli desil alkolden yaplr. Decyl Oleate ve Isodecyl Oleate makyaj, cilt ve saç bakm ürünleri dahil olmak üzere çeitli kozmetik ve kiisel bakm ürünlerinde kullanlr.
Decyl Oleate kozmetiklerde ve kiisel bakm ürünlerinde neden kullanlyor?
Decyl Oleate ve Isodecyl Oleate, cilt yüzeyinde yalayc olarak ilev görür ve cilde yumuak ve pürüzsüz bir görünüm verir. Bu içerikler ayn zamanda cilt üzerinde yal ve yapkan olmayan ince bir film oluturur. Decyl Oleate ve Isodecyl Oleate’in benzersiz özellikleri, makyajn uygulanmasn ve çkarlmasn kolaylatrr.
* Doal olarak oluan ya asidi oleik asitten yaplmtr.
Öncelikle kayganlatrc olarak kullanlr. Yumuak, Cilt bakm ürünü Cilde pürüzsüz ve yumuak bir görünüm veren ince, yasz bir film oluturur. Sk sk makyaj çkarmaya yönelik ürünlerde kullanlr. Bu maddeyi yüz nemlendirici / losyon, yalanma kart bakm, güne koruyucu, göz far, el ve ayak kremi, saç kremi, tra ve tra kremi gibi kozmetik ürünlerinde bulabilirsiniz. levler:
Öncelikle bir yalayc olarak kullanlr. Cilde pürüzsüz ve yumuak bir görünüm veren ince, yasz bir film oluturur. Sk sk makyaj çkarmaya yönelik ürünlerde kullanlr. Bu maddeyi yüz nemlendirici / losyon, yalanma kart bakm, güne koruyucu, göz far, el ve ayak kremi, saç kremi, tra ve tra kremi gibi kozmetik ürünlerinde bulabilirsiniz.
Güvenlik Önlemleri / Yan Etkiler:
Kozmetik çerik nceleme (CIR) Uzman Paneli, bu bileeni toksik olmayan ve tahri edici olmad için deerlendirmitir, bu nedenle kozmetik ürünlerinde kullanm güvenli olarak belirlenmitir. Komedojenik olduu (gözenekleri tkad) gösterilmitir ve yal ve akne eilimli cilt tipleri olanlar tarafndan kaçnlmaldr. Desil Oleat ve sdeasil Oleat, oleik asidin esterleridir. Decyl Oleate kullanlr
kozmetik ürünlerinde 1 ila% 50 arasnda deien konsantrasyonlarda. Isodecyl
Oleat,>% 0.1-25’lik konsantrasyonlarda kullanlr.
Hayvan çalmalar, Decyl Oleate ve lsodecyl Oleate’e
LD50’ler> 40 ml / kg olan sçanlarda düük akut oral toksisiteye sahip, tek kullanmlk dermal ve tavanlarla yaplan göz çalmalar bu materyalleri göstermitir.
% 100 konsantrasyonlar çok az tahri olur veya tahri etmez. 159b günlük uygulamalar
veya tavan derisine 60 gün boyunca% 100 konsantrasyonda orta derecede
Decyl ve lsodecyl Oleate ile tahri derecesi. Gine domuzlarnda konsantrasyonlarda test edildiinde, bileenlerin hiçbirinin duyarllatrc olduu bulunmad.
% 15
1-5’1’0 Decyl Oleate içeren tekrarlanan hakaret yama testleri
duyarllk belirtileri. % 5.5 Decyl Oleat içeren formülasyonlarla test etme
SchwartzPeck Prophetic Patch Test’teki 402 insan denekte ve seyreltilmemi lsodecyl Oleate ile 204 denekte düük sayda reaksiyon üretti.
Dokuz denek, maksimum 756’dan 1 .O’da toplam tahri skoru gösterdi.
Hem bu bileiklerin kimyasal benzerlii hem de mevcut hayvan ve insan verilerinin benzerlii nedeniyle, Decyl ve
Isodecyl Oleates, imdiki konsantrasyonlarda güvenli bir sonuç alnacan garanti ediyor
kozmetikte uygulamalar ve kullanm. ecyl Oleat ve Isodecyl Oleat, oleik asidin esterleridir. Oleik asidin desil veya izodecil alkol ile tanmlanmas ester-D ile oluur, bunlar:
yapsal formüller:
Decyl Oleat
sdesetil Oleat-CH3 (CH CH = CH (CH2) 7COOCH2 (CH2) 6CH (CH3) 27
Metil Oleat kimyasal olarak Decyl Oleate ve
sdesil Oleate. Yapsal formülü aadaki gibidir:
CH3 (CH2) 7CH = CH (CH2) 7COOCH3
Metil oleatn güvenlii bu raporda incelenmemektedir. Bilgi ve
Bu bileie ait veriler, Decyl Oleate ve Isodecyl Oleate’in güvenliinin daha tam bir deerlendirmesine izin vermek için dahil edilmitir. Bu esterlerin kimyasal ve fiziksel özelliklerinden bazlar;
Reaktivite
Doymam ya asitleri ve bunlarn esterleri kolayca dorulanr. ‘~)
Metil oleat, tüm oleik olan otoksidasyon reaksiyonlar için bir model görevi görebilir
asit esterleri sergilendi. Bu bileik, öncelikle vermek için otoksidasyona tabi tutulur.
yüksek oranda kararsz olan ve kolayca ayran trans-hidro peroksit ^, ‘^)
keto ve hidroksi keto asitleri (6) Baz hidroperoksitlerin
Kanserojen potansiyele sahiptir. “) Metil oleat fotokimyasal maddeye maruz kalyor
dorudan güne nda ve oksijenin varlnda
Metil oleik asidin ozonidi. (*) En önemli ikincil ürünler
otoksidasyon alfa, beta-nsatu dereceli karbonil bileimlerini içerir (5)
Bileenler, (‘) metaller, (lo) ve klorlu hidrokarbon asitler “”), indüksiyon periyodunu ksaltarak, otoksidasyon reaksiyonunu hzlandrr.
Analitik Yöntemler
Metil oleat,% 98 veya daha iyisi ile tekrarlanarak üretilebilir
Üre ile düük scaklkta damtma (‘2) Bunun ve ilgili bileiklerin analizi, gaz-sv veya ince-tabaka kromatografi ile yaplr. Pozisyonu
çift ba von Rudolph’un oksidasyon prosedürü ile belirlenebilir. Kzlötesi
Spektroskopi, cis-trans izomerlerini tanmlamak için kullanlabilir. (‘- ~~)
Her ne kadar gaz-sv kromatografisi ya asidi ester karmlar için tercih edilen rutin analitik yöntem olarak kalsa da, yüksek performansl svnn kullanlmas
kromatografi (HPLC) artyor; Sonuncusu, eskinin istemedii polimerlemi ve oksitlenmi esterleri tanmlama avantajna sahiptir.
KOZMETKTE KULLANIM AMACI VE FREKANSI
Desil ve sodesil Oleat kozmetik ürünlerinde yaygn olarak kullanlmaktadr. Sadece cilde uygulandnda, yal veya yapkan olmayan ince bir yal film brakrlar. yi yalama özelliklerine sahiptirler ve düük viskoziteye sahiptirler. (“) Kozmetik formülasyonlarnda her iki malzeme de datclar ve yalayclar olarak kullanlr,
ve bunlar özellikle demir oksit pigmentleri için slatc maddeler olarak kullanld makyaj ve makyaj sökücülerinde önemlidir; bu tür pigmentlerin parçacklar dalm ve kolayca askya alnmtr. Bu bileenlerin kullanm, bir süspansiyonun uygulanmasn ve çkarlmasn salar.
Dallanm zincir yapsndan dolay sodecyl Oleate birçok farkl özellie sahiptir. Emülsiyonun donma noktasn düürme özelliine sahiptir.
Ürünlerin viskozitesini kontrol etmenin yan sra ürünlerin faz. Dalabilir banyo yalarnda, küvet suyuna zengin ve sütlü bir görünüm veren beyaz bir emülsiyon oluturur. Ayrca kuru terlemeyi önleyici formülasyonlar için deerli klan alüminyum klorohidrat süspansiyon haline getirme özelliine de sahiptir. Ruj formülasyonlarnda lsodecyl Oleate kullanlmtr, çünkü birletirme özellikleri ak özelliklerini düürmeden ürünün sertliini ve gücünü arttrmaktadr.
Tablo 2, Decyl ve lsodecyl Oleate için ürün kullanm kategorilerini ve kullanm konsantrasyonlarn gösterir. (‘*) Gda ve laç daresi (FDA) tarafndan sunulan kozmetik ürün formülasyonu bilgisayar çkts, bu tür verilerin gönüllü olarak dosyalanmas yoluyla derlenmektedir. Balk 21 Bölüm 720.4 ile
Federal Yönetmelikler Kanunu (1979). Malzemeler, belirli ürün tipi kategorileri altnda belirtilen konsantrasyon aralklarnda listelenmitir. Baz kozmetik bileenler üretici tarafndan% 100 konsantrasyondan daha düük bir miktarda tedarik edildiinden, kozmetik formülatör tarafndan bildirilen deer mutlaka yanstlmayabilir.
bitmi üründe bulunan gerçek, etkili konsantrasyon; Böyle bir durumda etkili konsantrasyon, FDA’ya bildirilenlerin bir ksm olacaktr. Verilerin sadece önceden belirlenmi konsantrasyon aralklar çerçevesinde sunulmas, ayrca belirli bir üründeki bir bileenin fiili konsantrasyonunun fazla tahmin edilmesi için frsat salar. Bir konsantrasyon aralnn en alt ucundaki bir giri, o araln en yüksek ucuna girilen ile ayn olarak kabul edilir,
Böylece varsaylan bileen konsantrasyonunda iki ila on kat hata olasln ortaya koymaktadr. Bileikler, makyaj preparatlar, cilt bakm preparatlar ve göz far dahil olmak üzere çeitli kozmetiklerde kullanlr. Kullanm konsantrasyonlar, Decyl Oleat için 50.1 ila> ve>% 0.1-25 arasnda deimektedir.
Ben bir sznt yaptm. Bu iki materyali içeren ürünler cildin tüm alanlarna deiken sklkta uygulanr. Allk ve nemlendirici kremler gibi formülasyonlarda, maruz kalma, günde birkaç kez meydana gelebilirken, dier durumlarda günlük olabilir
(deodorantlar) veya daha az sklkta (durulama, saç kremi) uygulamalar. Bu ara sra veya günlük kullanm birkaç yl boyunca uzayabilir.
Hayvan Toksikolojisi
Desil Oleat: Bu bileen Wistar sçanlarna intragastrik entübasyon yoluyla 2,5, 5.0, 10.0, 20.0 ve 40.0 mllkg KOZMETK MADD NCELEME dozlarnda uygulanmtr.
doz bana iki dii sçan Hayvan dozajdan 24 saat önce aç brakld. Tüm hayvanlar, uygulamay takiben 14 gün boyunca günlük olarak gözlendi ve ölüm kaydedilmedi. Seyreltilmemi Decyl Oleat’in akut LD50’si 40.0 mg / kg vücut arlndan büyüktü. Wistar türevli sçanlara (be erkek, be dii olan gruplar), 5.0 glkg seyreltilmemi Decyl Oleat veya 5.0 glkg yüzde 20 Decyl içeren gavaj verildi.
Oleat,% 80 mineral Fareler dozlamadan 18 saat önce aç braklmtr. Hayvanlar, dozlamadan 1, 3, 6 ve 24 saat sonra farmakolojik aktivite ve ilaç toksisitesi belirtileri açsndan gözlendi, ardndan
toplam 14 gün. Seyreltilmi örnek grubundaki erkek hayvanlar için bir ölüm kaydedilmitir ve seyreltilmi örnek ile muameleden sonra bir dii ölmütür. Hayatta kalan hayvanlarn hiçbirinde tedavi ile ilgili bir etki görülmemitir. Brüt otopside nons, traviv ve kurtulan dokularn incelenmesi herhangi bir anormallik göstermedi.
sdodesil Oleat: Bu bileen, Wistar sçanlarna intragastrik entübasyon yoluyla 2.5, 5.0, 10.0, 20.0 ve 40.0 mllkg doz seviyelerinde (doz bana iki dii ve üç erkek sçan) uyguland.
Doz vermeden önceki saatler. Bir ölüm en yüksek doz seviyesinde kaydedildi. Seyreltilmemi Isodesil Oleat’in akut LD50’sinin 40.0 ml / kg vücut arlndan büyük olduu rapor edildi.
Dermal tahri
Decyl Oleate: Drai ~ ‘) ve Federal Tehlikeli Maddeler Etiketleme Yasas (22) (FHSA) yöntemleri cilt tahriini incelemek için kullanlmtr. Decyl Oleat test numuneleri (seyreltilmemi, msr yanda yüzde 10 ve mineralde yüzde 20)
ya), salam ve anm albino tavan derisinin krplm alanlarna (her grupta alt hayvan) uyguland (0,5 mi). Anmalar uzunlamasna, epidermal insizyonlar stratum korneum’a girebilecek kadar derindi, ancak dermisi rahatsz edecek kadar derin deildi. Test malzemesinin uygulanmasndan sonra, maruz kalan alan
bir yama ile kapatld ve deney alannn tamam geçirimsiz tabakalarla kapatld. Hayvanlar 24 saatlik bir süre boyunca hareketsiz hale getirildi. Son tahri deerlerini belirlemek için ortalama 24 ve 72 saatlik kademeler için puanlarn ortalamas alnd. Seyreltilmemi Decyl Oleat için primer tahri indeksi (PII) 0.28.L25 olarak hesaplanmtr. mineral
Seyreltilmemi ve polioksietilen sorbitan stearat (% 3), bir perservatif (% 2)) ve su içerisinde seyreltilmi% 15 Decyl Oleat ile seyreltilmi ve% 15 Decyl Oleat ile primer dermal tahri çalmalarn yapmak için modifiye edilmi bir Draize yöntemi kullanld; malzemenin tahri edici olmad bulundu (Tablo 3). (“j)
sdodesil Oleat: Bu bileen (0,5 mi), krplarak seyreltilmeden uyguland. üç albino tavann salam ve anm derisi. Yama alan ile kaplydWebril yamalar ve tüm deney alan Blenderm ile kapatld
Cerrahi bant. Hayvanlar 24 saat snrlama stoklarnda kaldktan sonra,Yamalar çkarld ve tedavi edilen cilt, Draize yöntemi. Deri 72 saat sonra tekrar deerlendirildi ve primer tahri indeksi hesapland. sodesil Oleat PI1’e sahip Özet bir raporda, seyreltilmemi olduu tespit edildi.
Tavanlar cildine uygulanan sodekil Oleat, primer tahri indeksine sahipti. Decyl Oleate: Decyl Oleate her hafta sekiz hafta cildine uyguland.
tavanlar; FHSA yöntemi hafif deiikliklerle kullanlmtr. fizyolojik salin içinde trol, msr ya (% 0.1), Test materyali ile ayn miktarda verilir. Enjeksiyondan yirmi dört saat sonra, herhangi bir reaksiyonun çap, yükseklii ve kzarkl için skorlar kaydedildi ve 10 hassaslatrc enjeksiyon için ortalama puanlar, meydan okuma enjeksiyonlar ile karlatrld. Eer meydan okuma puan, esasen ortalama deerden yüksekse, duyarllk bildirilecektir. Decyl Oleate, meydan okuma üzerine daha yüksek deerler sergilemedii için, bir duyarszlatrc olduu kabul edilir