DIMETHYL ETHANOL AMINE (DMETL ETANOL AMN)
DIMETHYL ETHANOL AMINE (DMETL ETANOL AMN)
CAS No. : 108-01-0
EC No. : 203-542-8
Synonyms:
2-(Dimethylamino)ethanol; Deanol; N,N-Dimethylethanolamine; 108-01-0; Dimethylaminoethanol; Dimethylethanolamine; Norcholine; 2-DIMETHYLAMINOETHANOL; DMAE; DMEA; Bimanol; Liparon; N,N-Dimethylaminoethanol; Varesal; Propamine A; Ethanol, 2-(dimethylamino)-; (2-Hydroxyethyl)dimethylamine; Kalpur P; N-Dimethylaminoethanol; Dimethylmonoethanolamine; Dimethylaminoaethanol; N,N-Dimethyl-2-aminoethanol; Amietol M 21; N,N-Dimethyl-2-hydroxyethylamine; N,N-Dimethyl ethanolamine; 2-(N,N-Dimethylamino)ethanol; Dimethyl(hydroxyethyl)amine; Texacat DME; Dimethylaethanolamin; Dimethyl(2-hydroxyethyl)amine; 2-(Dimethylamino)-1-ethanol; N-(2-Hydroxyethyl)dimethylamine; N,N-Dimethyl-N-(2-hydroxyethyl)amine; 2-(Dimethylamino) ethanol; Demanol; Demanyl; Tonibral; (Dimethylamino)ethanol; beta-Hydroxyethyldimethylamine; 2-(dimethylamino)ethan-1-ol; 2-Dimethylamino-ethanol; beta-Dimethylaminoethyl alcohol; 2-Dwumetyloaminoetanolu; N-(Dimethylamino)ethanol; N,N-Dimethyl-N-(beta-hydroxyethyl)amine; Tegoamin DMEA; NSC 2652; Dabco DMEA; UNII-2N6K9DRA24; Dimethylaethanolamin [German]; Dimethylaminoaethanol [German]; Deanol [BAN]; CCRIS 4802; 2-Dwumetyloaminoetanolu [Polish]; HSDB 1329; 2-Dimethylamino ethanol; N,N-Dimethyl(2-hydroxyethyl)amine; EINECS 203-542-8; N,N’-Dimethylethanolamine; UN2051; 2-(dimethylamino)-ethanol; BRN 1209235; (CH3)2NCH2CH2OH; MFCD00002846; N,N-DIMETHYLAMINOETHANOL (DMAE); NCGC00159413-02; N,N-Dimethyl-N-(.beta.-hydroxyethyl)amine; DSSTox_CID_505; 2-Dimethylaminoethanol [UN2051] [Corrosive]; DSSTox_RID_75628; DSSTox_GSID_20505; N,N-Dimethylethanolamine (2-Dimethylaminoethanol); N,N-Dimethylethanolamine, 99%; Deanol (N,N-Dimethylethanolamine); CAS-108-01-0; Dimethylamino ethanol; Jeffcat DMEA; Dimethylethanoiamine; Toyocat -DMA; dimethyl ethanolamine; dimethyl-ethanolamine
EN
Dimethyl Ethanol Amine (Dimetil Etanol Amine) IUPAC Name 2-(dimethylamino)ethanol
Dimethyl Ethanol Amine (Dimetil Etanol Amine) InChI 1S/C4H11NO/c1-5(2)3-4-6/h6H,3-4H2,1-2H3
Dimethyl Ethanol Amine (Dimetil Etanol Amine) InChI Key UEEJHVSXFDXPFK-UHFFFAOYSA-N
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Canonical SMILES CN(C)CCO
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Molecular Formula C4H11NO
Dimethyl Ethanol Amine (Dimetil Etanol Amine) CAS 108-01-0
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Deprecated CAS 116134-09-9, 156681-25-3
Dimethyl Ethanol Amine (Dimetil Etanol Amine) European Community (EC) Number 203-542-8
Dimethyl Ethanol Amine (Dimetil Etanol Amine) ICSC Number 0654
Dimethyl Ethanol Amine (Dimetil Etanol Amine) NSC Number 2652
Dimethyl Ethanol Amine (Dimetil Etanol Amine) RTECS Number KK6125000
Dimethyl Ethanol Amine (Dimetil Etanol Amine) UN Number 2051
Dimethyl Ethanol Amine (Dimetil Etanol Amine) UNII 2N6K9DRA24
Dimethyl Ethanol Amine (Dimetil Etanol Amine) DSSTox Substance ID DTXSID2020505
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Physical Description Liquid
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Color/Form Colorless liquid
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Odor Amine odor
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Boiling Point 275 °F at 758 mm Hg
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Melting Point -74 °F
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Flash Point 105 °F
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Solubility greater than or equal to 100 mg/mL at 73° F
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Density 0.887 at 68 °F
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Vapor Density 3.03
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Vapor Pressure 7.8 mm Hg at 72 °F ; 18.8 mm Hg at 103.1° F; 77.5 mm Hg at 155.3° F
Dimethyl Ethanol Amine (Dimetil Etanol Amine) LogP log Kow = -0.55 at 23 °C
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Atmospheric OH Rate Constant 9.00e-11 cm3/molecule*sec
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Stability/Shelf Life Stable under recommended storage conditions.
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Autoignition Temperature 563 °F
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Decomposition When heated to decomposition it emits toxic fumes of NOx.
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Viscosity 3.5839 mPa.s at 21.6 °C
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Heat of Vaporization 42.7-43.2 kJ/mol
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Surface Tension 28.2 mN/m at 20 °C
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Refractive Index Index of refraction: 1.4300 at 20 °C
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Dissociation Constants pKa = 9.3
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Other Experimental Properties Bulk density wt/gal at 20 °C: 7.4 lb/gal
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Molecular Weight 89.14 g/mol
Dimethyl Ethanol Amine (Dimetil Etanol Amine) XLogP3-AA -0.4
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Hydrogen Bond Donor Count 1
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Hydrogen Bond Acceptor Count 2
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Rotatable Bond Count 2
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Exact Mass 89.084064 g/mol
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Monoisotopic Mass 89.084064 g/mol
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Topological Polar Surface Are 23.5 Ų
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Heavy Atom Count 6
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Formal Charge 0
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Complexity 28.7
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Isotope Atom Count 0
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Defined Atom Stereocenter Count 0
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Undefined Atom Stereocenter Count 0
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Defined Bond Stereocenter Count 0
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Undefined Bond Stereocenter Count 0
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Covalently-Bonded Unit Count 1
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Compound Is Canonicalized Yes
Dimethyl Ethanol Amine (Dimetil Etanol Amine) is commonly referred to as 2-(dimethylamino)ethanol, dimethylaminoethanol (DMAE) or dimethylethanolamine (DMEA). It holds tertiary amine and primary alcohol groups as functional groups. Dimethyl Ethanol Amine (Dimetil Etanol Amine) has been used in the treatment of attention deficit-hyperactivity disorder (ADHD), Alzheimer’s disease, autism, and tardive dyskinesia. It has been also used as an ingredient in skin care, and in cognitive function- and mood-enhancing products.No beneficial effects were obtained when Dimethyl Ethanol Amine (Dimetil Etanol Amine) was administered to 11 patients with tardive dyskinesia of long duration. Doses of Dimethyl Ethanol Amine (Dimetil Etanol Amine) were increased gradually over a period of 9 days until a level of 400 mg 4 times a day was reached; this dose level was then maintained for an additional 9 days.Two case reports are presented in which Dimethyl Ethanol Amine (Dimetil Etanol Amine) (I) was used unsuccessfully to treat tardive dyskinesia. The first case report involved an 89-yr-old male with a 50 yr history of chronic paranoid schizophrenia and symptoms of tardive dyskinesia. I was administered in doses ranging from 450 to 600 mg daily for 5 months but had to be discontinued due to the development of marked sialism, bronchospasm, and parkinson rigidity. No change in the patient’s tardive dyskinesia was noted. A second patient with tardive dyskinesia and a 30 yr history of schizophrenia received up to 800 mg daily of I for 5 months with no improvement noted.Dimethyl Ethanol Amine (Dimetil Etanol Amine) therapy proved successful in 4 patients with tardive dyskinesia due to psychotherapeutic agents; the effect of Dimethyl Ethanol Amine (Dimetil Etanol Amine) was apparent while the offending agent was still being used.Poor results were reported when dimethylaminoethanol (Dimethyl Ethanol Amine (Dimetil Etanol Amine)) was used to treat 17 patients with Huntington’s chorea. Dimethyl Ethanol Amine (Dimetil Etanol Amine) was started at a dosage of 50 to 300 mg/day, which was increased slowly in the more fragile patients to 200 mg to 300 mg/day as tolerated, and more rapidly in the vigorous patients to 400 to 1200 mg/day over the course of a few weeks. Of the 17 patients, Dimethyl Ethanol Amine (Dimetil Etanol Amine) therapy was stopped in 11 after 2 to 9 months because of increased petulance, insomnia and resentment of treatment failure. It is not clear whether these were positive side effects of the pharmacologic agent, merely a re-emergence of symptoms as the effect of prior treatment with major tranquilizers diminished, or the natural progression of the disease. Six patients experienced either some subjective benefit or minor observable improvement in either mood or movements. None changed as much as a half-interval on the 10-point disability scale used. No serious behavioral, medical or biochemical side effects occurred.Dimethyl Ethanol Amine (Dimetil Etanol Amine) (I) therapy in 4 patients with tardive dyskinesia is reported. Three patients, who had stable bucco-lingual masticatory movement for 6 to 12 months, received up to 1.6-2 g a day of Dimethyl Ethanol Amine (Dimetil Etanol Amine) for 21 to 56 days with no improvement. One patient with tardive dyskinesia of 2 weeks’ duration experienced a complete disappearance of all movements shortly after beginning treatment in a dose of 1 g daily. Discontinuation of Dimethyl Ethanol Amine (Dimetil Etanol Amine) resulted in no recurrence of symptoms. Dimethyl Ethanol Amine (Dimetil Etanol Amine) is not effective for well established cases of tardive dyskinesia.Cholinergic drugs have been used to treat tardive dyskinesia. /The objective of the study was/ to determine the effects of cholinergic drugs (arecoline, choline, Dimethyl Ethanol Amine (Dimetil Etanol Amine), lecithin, meclofenoxate, physostigmine, RS 86, tacrine, metoxytacrine, galantamine, ipidacrine, donepezil, rivastigmine, eptastigmine, metrifonate, xanomeline, cevimeline) for treating neuroleptic-induced tardive dyskinesia in people with schizophrenia or other chronic mental illness. Dimethyl Ethanol Amine (Dimetil Etanol Amine) may cause gastric adverse effects (5 RCTs, 61 people, RR 9.00 CI 0.55-148) and other adverse effects such as sedation and peripheral cholinergic effects (6 RCTs, 94 people, RR 6.83 CI 0.99-47). One study reported on global outcome.10 Chronic psychotic pt with symptoms of tardive dyskinesia; 7 given Dimethyl Ethanol Amine (Dimetil Etanol Amine) & 3 placebos for 8 wk. Improvement occurred in all pt regardless of treatment. Dimethyl Ethanol Amine (Dimetil Etanol Amine) may have contributed to decline but effect was not dramatic.Serious cholinergic side effects were reported in a 37-yr-old woman with tardive dyskinesia who had been taking Dimethyl Ethanol Amine (Dimetil Etanol Amine). Dimethyl Ethanol Amine (Dimetil Etanol Amine) was given for 19 days in increasing doses. After 17 days, while receiving 1.5 g/day, the patient began to experience symptoms.Dimethyl Ethanol Amine (Dimetil Etanol Amine) (400-6000 mg/day for 1-4 mo) admin to pt with involuntary movement disorders produced mood changes (depression or hypomania) only in those pt with tardive dyskinesia with a past history of psychiatric disorders.Daily oral exposures (Dimethyl Ethanol Amine (Dimetil Etanol Amine) acetamidobenzoate, DMAE, or Deaner) of chinchilla rabbits or humans produced measurable plasma and cerebrospinal concentrations of the parent compound. The drugs were cleared from the plasma by 36 hours post-treatment.Specific methods utilizing combined gas chromatography mass spectrometry were used to measure the metabolism of [(2)H6]Dimethyl Ethanol Amine (Dimetil Etanol Amine) and its effects on acetylcholine concentration in vitro and in vivo. In vitro [(2)H6]Dimethyl Ethanol Amine (Dimetil Etanol Amine) was rapidly taken up by rat brain synaptosomes, but was neither methylated nor acetylated. [(2)H6]Dimethyl Ethanol Amine (Dimetil Etanol Amine) was a weak competitive inhibitor of the high affinity transport of [(2)H4]choline, thus reducing the synthesis of [(2)H4]acetylcholine. In vivo [(2)H6]Dimethyl Ethanol Amine (Dimetil Etanol Amine) was present in the brain after i.p. or p.o. administration, but was not methylated or acetylated. Treatment of rats with [(2)H6]Dimethyl Ethanol Amine (Dimetil Etanol Amine) significantly increased the concentration of choline in the plasma and brain but did not alter the concentration of acetylcholine in the brain. Treatment of rats with atropine (to stimulate acetylcholine turnover) or with hemicholinium-3 (to inhibit the high affinity transport of choline) did not reveal any effect of [(2)H6]Dimethyl Ethanol Amine (Dimetil Etanol Amine) on acetylcholine synthesis in vivo. However, since [(2)H6]Dimethyl Ethanol Amine (Dimetil Etanol Amine) did increase brain choline, it may prove therapeutically useful when the production of choline is reduced or when the utilization of choline for the synthesis of acetylcholine is impaired.Specific methods utilizing combined gas chromatography mass spectrometry were used to measure the metabolism of [(2)H6]Dimethyl Ethanol Amine (Dimetil Etanol Amine) and its effects on acetylcholine concentration in vitro and in vivo. In vitro [(2)H6]Dimethyl Ethanol Amine (Dimetil Etanol Amine) was rapidly taken up by rat brain synaptosomes, but was neither methylated nor acetylated. [(2)H6]Dimethyl Ethanol Amine (Dimetil Etanol Amine) was a weak competitive inhibitor of the high affinity transport of [(2)H4]choline, thus reducing the synthesis of [(2)H4]acetylcholine. In vivo [(2)H6]Dimethyl Ethanol Amine (Dimetil Etanol Amine) was present in the brain after i.p. or p.o. administration, but was not methylated or acetylated. Treatment of rats with [(2)H6]Dimethyl Ethanol Amine (Dimetil Etanol Amine) significantly increased the concentration of choline in the plasma and brain but did not alter the concentration of acetylcholine in the brain. Treatment of rats with atropine (to stimulate acetylcholine turnover) or with hemicholinium-3 (to inhibit the high affinity transport of choline) did not reveal any effect of [(2)H6]Dimethyl Ethanol Amine (Dimetil Etanol Amine) on acetylcholine synthesis in vivo. However, since [(2)H6]Dimethyl Ethanol Amine (Dimetil Etanol Amine) did increase brain choline, it may prove therapeutically useful when the production of choline is reduced or when the utilization of choline for the synthesis of acetylcholine is impaired.2-Dimethylaminoethanol (DMAE) (also known as Dimethyl Ethanol Amine (Dimetil Etanol Amine)) has been used as an ingredient in skin care, and in cognitive function- and mood-enhancing products.Dimethyl Ethanol Amine (Dimetil Etanol Amine) ACETAMIDOBENZOATE /WHICH/ IS THE P-ACETAMIDOBENZOIC ACID SALT OF 2-(DIMETHYLAMINO)ETHANOL (Dimethyl Ethanol Amine (Dimetil Etanol Amine)). /Dimethyl Ethanol Amine (Dimetil Etanol Amine) ACETAMIDOBENZOATE/2-Dimethylaminoethanol (DMAE) (also known as Dimethyl Ethanol Amine (Dimetil Etanol Amine)) has been used as an ingredient in skin care, and in cognitive function- and mood-enhancing products. It is marketed as a free base or salt, and in theory, the two forms should be equally effective and able to substitute for each other in pharmaceutical formulations.A method is described for the simultaneous determination of Dimethyl Ethanol Amine (Dimetil Etanol Amine) & choline in biological samples. The compd were measured by gas chromatography-mass spectrometry using a silanized glass column packed with 5% ddts, 5% ov-101 on GC 22, 100/200 mesh at 100 °C.Dimethyl Ethanol Amine (Dimetil Etanol Amine) determination in tissue by gas chromatography.Dithiocarb and (+)-cyanidanol-3-prevented paracetamol-induced liver injury in rats in vivo. Both, as well as two other antihepatotoxic agents, Dimethyl Ethanol Amine (Dimetil Etanol Amine) and DMSO, inhibited covalent binding of [(3)H]-paracetamol to rat liver microsomal proteins in vitro. Dithiocarb and (+)-cyanidanol-3 were the most effective inhibitors. The concentrations of the antidotes yielding 50% inhibition (I50) valued 1.8 x 10(-5) M for dithiocarb and 2.1 x 10(-5) M for (+)-cyanidanol-3.Larger doses produced insomnia, muscle tenseness, and spontaneous muscle twitches. Serious cholinergic side effects were reported in a 37-yr-old woman with tardive dyskinesia who had been taking Dimethyl Ethanol Amine (Dimetil Etanol Amine). The present 2-phase randomized double-blind split face study was designed to compare the effect of a gel containing 3% 2-dimethylaminoethanol (Dimethyl Ethanol Amine (Dimetil Etanol Amine), DMAE) with the same formulation without DMAE. Skincare formulations for the improvement of aging skin are increasingly important consumer products. Here, we review available data on one such agent – 2-dimethylaminoethanol (DMAE) or Dimethyl Ethanol Amine (Dimetil Etanol Amine) – that has recently been evaluated in a placebo-controlled trial.Seventy-four children referred for problems with learning, including many with hyperactivity, were screened for neurological or psychiatric illness, then given Dimethyl Ethanol Amine (Dimetil Etanol Amine), methylphenidate, or placebo in a double-blind fashion for 3 months. Maintenance dose for methylphenidate was 40 mg daily; for Dimethyl Ethanol Amine (Dimetil Etanol Amine), 500 mg. Behavior rating forms, reaction time, and a series of standard psychometric tests were given before and after treatment. Both drugs showed significant improvement on a number of tests; the pattern and degree of change differed slightly for the 2. In this paradigm, Dimethyl Ethanol Amine (Dimetil Etanol Amine) thus appeared to improve performance in children with learning and behavior disorders. The mechanism of action remains speculative; proof that Dimethyl Ethanol Amine (Dimetil Etanol Amine) increases acetylcholine is scanty, and there is a theoretical basis for actually assuming an anticholinergic effect.
TR
Dimethyl Ethanol Amine (Dimetil Etanol Amine) IUPAC Ad 2- (dimetilamino) etanol
Dimethyl Ethanol Amine (Dimetil Etanol Amine) InChI 1S / C4H11NO / c1-5 (2) 3-4-6 / h6H, 3-4H2,1-2H3
Dimethyl Ethanol Amine (Dimetil Etanol Amine) InChI Key UEEJHVSXFDXPFK-UHFFFAOYSA-N
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Kanonik SMILES CN (C) CCO
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Moleküler Formül C4H11NO
Dimethyl Ethanol Amine (Dimetil Etanol Amine) CAS 108-01-0
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Kullanmdan Kaldrlm CAS 116134-09-9, 156681-25-3
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Avrupa Topluluu (EC) Numaras 203-542-8
Dimethyl Ethanol Amine (Dimetil Etanol Amine) ICSC Numaras 0654
Dimethyl Ethanol Amine (Dimetil Etanol Amine) NSC Numaras 2652
Dimethyl Ethanol Amine (Dimetil Etanol Amine) RTECS Numaras KK6125000
Dimethyl Ethanol Amine (Dimetil Etanol Amine) UN Numaras 2051
Dimethyl Ethanol Amine (Dimetil Etanol Amine) UNII 2N6K9DRA24
Dimethyl Ethanol Amine (Dimetil Etanol Amine) DSSTox Madde Kimlii DTXSID2020505
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Fiziksel Tanmlama Sv
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Renk / Form Renksiz sv
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Koku Amin kokusu
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Kaynama Noktas 275 ° F, 758 mm Hg’de
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Erime Noktas -74 ° F
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Parlama Noktas 105 ° F
Dimethyl Ethanol Amine (Dimetil Etanol Amine) 73 ° F’de 100 mg / mL’den büyük veya buna eit çözünürlük
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Younluk 68 ° F’de 0.887
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Buhar Younluu 3.03
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Buhar Basnc 72 ° F’de 7,8 mm Hg; 103.1 ° F’de 18.8 mm Hg; 155,3 ° F’de 77,5 mm Hg
Dimethyl Ethanol Amine (Dimetil Etanol Amine) LogP log Kow = -0,55 23 ° C’de
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Atmosferik OH Oran Sabiti 9.00e-11 cm3 / molekül * sn
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Kararllk / Raf Ömrü Önerilen depolama koullarnda kararldr.
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Kendiliinden Tutuma Scakl 563 ° F
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Bozunma Bozunma için stldnda toksik NOx dumanlar yayar.
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Viskozite 3.5839 mPa.s nin 21.6 ° C
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Buharlama Iss 42.7-43.2 kJ / mol
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Yüzey Gerilimi 20 ° C’de 28.2 mN / m
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Krlma ndeksi Krlma ndeksi: 20 ° C’de 1.4300
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Ayrlma Sabitleri pKa = 9.3
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Dier Deneysel Özellikler 20 ° C’de kütle younluu wt / gal: 7,4 lb / gal
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Molekül Arl 89,14 g / mol
Dimethyl Ethanol Amine (Dimetil Etanol Amine) XLogP3-AA -0.4
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Hidrojen Ba Donör Says 1
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Hidrojen Ba Alc Says 2
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Dönebilen Ba Says 2
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Tam Kütle 89.084064 g / mol
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Monoizotopik Kütle 89.084064 g / mol
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Topolojik Polar Yüzey 23.5 Ų’dir
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Ar Atom Says 6
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Resmi Yük 0
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Karmaklk 28.7
Dimethyl Ethanol Amine (Dimetil Etanol Amine) zotop Atom Says 0
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Tanml Atom Stereo Merkez Saym 0
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Tanmsz Atom Stereo Merkez Saym 0
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Tanml Ba Stereocenter Says 0
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Tanmsz Ba Stereocenter Says 0
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Kovalent Bal Birim Says 1
Dimethyl Ethanol Amine (Dimetil Etanol Amine) Bileii Kanonikalize Edilmitir Evet
Dimethyl Ethanol Amine (Dimetil Etanol Amine) genellikle 2- (dimetilamino) etanol, dimetilaminoetanol (DMAE) veya dimetiletanolamin (DMEA) olarak anlr. Üçüncül amin ve birincil alkol gruplarn fonksiyonel gruplar olarak tutar. Dimethyl Ethanol Amine (Dimetil Etanol Amine), dikkat eksiklii hiperaktivite bozukluu (ADHD), Alzheimer hastal, otizm ve geç diskinezi tedavisinde kullanlmtr. Ayrca cilt bakm, bilisel ilev ve duygudurum artrc ürünlerde bir bileen olarak kullanlmtr.Dimethyl Ethanol Amine (Dimetil Etanol Amine) uzun süreli geç diskinezi olan 11 hastaya uygulandnda yararl bir etki elde edilmemitir. Dimethyl Ethanol Amine (Dimetil Etanol Amine) dozlar, 9 günlük bir süre içinde kademeli olarak 400 düzeyine yükseltildi.günde 4 kez mg’a ulald; Bu doz seviyesi daha sonra 9 gün daha korunmutur. Dimethyl Ethanol Amine (Dimetil Etanol Amine) (I) ‘in geç diskineziyi tedavi etmek için baarsz bir ekilde kullanld iki vaka raporu sunulmutur. lk vaka raporu, 50 yllk kronik paranoid izofreni öyküsü ve geç diskinezi semptomlar olan 89 yanda bir erkei içeriyordu. 5 ay boyunca günlük 450 ila 600 mg arasnda deien dozlarda uygulandm, ancak belirgin siyalizm, bronkospazm ve parkinson sertlii gelimesi nedeniyle kesilmek zorunda kaldm. Hastann geç diskinezisinde herhangi bir deiiklik kaydedilmedi. Tardif diskinezi ve 30 yllk izofreni öyküsü olan ikinci bir hasta, 5 ay boyunca herhangi bir iyileme kaydedilmeden günde 800 mg’a kadar I ald. Dimethyl Ethanol Amine (Dimetil Etanol Amine) tedavisi, psikoterapötik ajanlara bal geç diskinezi olan 4 hastada baarl oldu ; Dimetil Etanol Amin’in (Dimetil Etanol Amin) etkisi, rahatsz edici ajan hala kullanlrken belirgindi. 17 hastay Huntington koresi ile tedavi etmek için dimetilaminoetanol (Dimethyl Ethanol Amine (Dimetil Etanol Amine)) kullanldnda kötü sonuçlar bildirildi. Dimethyl Ethanol Amine (Dimetil Etanol Amine) 50-300 mg / gün dozunda baland, bu doz daha krlgan hastalarda tolere edildiinde yavaça 200 mg ile 300 mg / gün’e, iddetli hastalarda daha hzl olarak 400’e yükseltildi. Birkaç hafta boyunca 1200 mg / gün’e. 17 hastadan Dimethyl Ethanol Amine (Dimetil Etanol Amine) tedavisi, artan titreme, uykusuzluk ve tedavi baarszlna kzgnlk nedeniyle 2-9 ay sonra 11’de durduruldu. Bunlarn farmakolojik ajann pozitif yan etkileri olup olmad, yalnzca majör sakinletiricilerle önceki tedavinin etkisi azaldndan semptomlarn yeniden ortaya çkmas veya hastaln doal ilerlemesi olup olmad açk deildir. Alt hasta, ya ruh hali ya da hareketlerinde bir miktar öznel fayda ya da küçük gözlenebilir iyileme yaad. Kullanlan 10 puanlk engellilik ölçeinde hiçbiri yarm aralk kadar deimedi. Tardif diskinezi olan 4 hastada ciddi davransal, tbbi veya biyokimyasal yan etki olumad. Dimethyl Ethanol Amine (Dimetil Etanol Amine) (I) tedavisi bildirildi. 6 ila 12 ay boyunca stabil bukko-lingual çineme hareketine sahip olan üç hasta, 21 ila 56 gün boyunca günde 1.6-2 g Dimethyl Ethanol Amine (Dimetil Etanol Amine) düzelmeden ald. 2 hafta süreli geç diskinezi olan bir hasta, tedaviye baladktan ksa bir süre sonra, günlük 1 g’lk bir dozda tüm hareketlerde tamamen kayboldu. Dimethyl Ethanol Amine (Dimetil Etanol Amine) tedavisinin kesilmesi semptomlarn nüksetmesine neden olmad. Dimethyl Ethanol Amine (Dimetil Etanol Amine), iyi bilinen tardif diskinezi vakalarnda etkili deildir. Geç diskineziyi tedavi etmek için holinerjik ilaçlar kullanlmtr. / Çalmann amac kolinerjik ilaçlarn (arecoline, kolin, Dimethyl Ethanol Amine (Dimetil Etanol Amine), lesitin, meklofenoksat, fizostigmin, RS 86, takrin, metoksitakrin, galantamin, ipidakrin, donepezil, rivastigmin, eptastigmin, metrifonat, xanomeline, cevimeline) izofreni veya dier kronik akl hastal olan kiilerde nöroleptik kaynakl tardif diskinezi tedavisi için. Dimethyl Ethanol Amine (Dimetil Etanol Amine), mide yan etkilerine (5 RCT, 61 kii, RR 9.00 CI 0.55-148) ve sedasyon ve periferal kolinerjik etkiler gibi dier olumsuz etkilere (6 RCT, 94 kii, RR 6.83 CI 0.99- neden olabilir) 47). Küresel sonuç üzerine bir çalma bildirilmitir.10 Tardif diskinezi semptomlar olan kronik psikotik pt; 7 Dimethyl Ethanol Amine (Dimetil Etanol Amine) ve 8 hafta süreyle 3 plasebo verildi. Tedaviden bamsz olarak tüm pt’de iyileme meydana geldi. Dimethyl Ethanol Amine (Dimetil Etanol Amine) düüe katkda bulunmu olabilir, ancak etki dramatik deildi. 37 yanda, Dimethyl Ethanol Amine (Dimetil Etanol Amine) alan tardif diskinezi olan bir kadnda ciddi kolinerjik yan etkiler bildirilmitir. Dimethyl Ethanol Amine (Dimetil Etanol Amine) artan dozlarda 19 gün süreyle verildi. 17 gün sonra, 1.5 g / gün alrken hasta semptomlar yaamaya balad. Dimethyl Ethanol Amine (Dimetil Etanol Amine) (1-4 ay için 400-6000 mg / gün), istemsiz hareket bozukluklar ile pt’ye uygulandnda duygudurum deiiklikleri oluturdu ( depresyon veya hipomani) sadece geçmi psikiyatrik bozukluk öyküsü olan geç diskinezi hastalarnda. Çinçilla tavanlarnn veya insanlarn günlük oral maruziyetleri (Dimethyl Ethanol Amine (Dimetil Etanol Amine) asetamidobenzoat, DMAE veya Deaner), ölçülebilir plazma ve beyin omurilik konsantrasyonlar üretti. ana bileik. laçlar, ilemden 36 saat sonra plazmadan temizlendi. [(2) H6] Dimethyl Ethanol Amine (Dimetil Etanol Amine) metabolizmasn ve asetilkolin konsantresi üzerindeki etkilerini ölçmek için kombine gaz kromatografisi kütle spektrometrisini kullanan spesifik yöntemler kullanld.in vitro ve in vivo. n vitro [(2) H6] Dimethyl Ethanol Amine (Dimetil Etanol Amine), sçan beyin sinaptozomlar tarafndan hzla alnd, ancak ne metillendi ne de asetillendi. [(2) H6] Dimethyl Ethanol Amine (Dimetil Etanol Amine), [(2) H4] kolinin yüksek afiniteli tanmasnn zayf rekabetçi bir inhibitörüdür, dolaysyla [(2) H4] asetilkolinin sentezini azaltr. n vivo [(2) H6] Dimethyl Ethanol Amine (Dimetil Etanol Amine) i.p.’den sonra beyinde mevcuttu. veya p.o. uygulama, ancak metillenmemi veya asetillenmemi. Sçanlarn [(2) H6] Dimethyl Ethanol Amine (Dimetil Etanol Amine) ile muamelesi, plazma ve beyindeki kolin konsantrasyonunu önemli ölçüde arttrd, ancak beyindeki asetilkolin konsantrasyonunu deitirmedi. Sçanlarn atropinle (asetilkolin döngüsünü uyarmak için) veya hemikolinium-3 (kolinin yüksek afinite tanmasn engellemek için) ile muamelesi, [(2) H6] Dimethyl Ethanol Amine (Dimetil Etanol Amine) ‘in asetilkolin sentezi üzerinde herhangi bir etki göstermedi. vivo. Bununla birlikte, [(2) H6] Dimethyl Ethanol Amine (Dimetil Etanol Amine) beyin kolini arttrd için, kolin üretimi azaldnda veya asetilkolin sentezi için kolin kullanm bozulduunda terapötik olarak yararl olabilir. [(2) H6] Dimethyl Ethanol Amine (Dimetil Etanol Amine) metabolizmasn ve bunun asetilkolin konsantrasyonu üzerindeki etkilerini in vitro ve in vivo olarak ölçmek için kombine gaz kromatografisi kütle spektrometresi kullanlarak kullanlmtr. n vitro [(2) H6] Dimethyl Ethanol Amine (Dimetil Etanol Amine), sçan beyin sinaptozomlar tarafndan hzla alnd, ancak ne metillendi ne de asetillendi. [(2) H6] Dimethyl Ethanol Amine (Dimetil Etanol Amine), [(2) H4] kolinin yüksek afiniteli tanmasnn zayf rekabetçi bir inhibitörüdür, dolaysyla [(2) H4] asetilkolinin sentezini azaltr. n vivo [(2) H6] Dimethyl Ethanol Amine (Dimetil Etanol Amine) i.p.’den sonra beyinde mevcuttu. veya p.o. uygulama, ancak metillenmemi veya asetillenmemi. Sçanlarn [(2) H6] Dimethyl Ethanol Amine (Dimetil Etanol Amine) ile muamelesi, plazma ve beyindeki kolin konsantrasyonunu önemli ölçüde arttrd, ancak beyindeki asetilkolin konsantrasyonunu deitirmedi. Sçanlarn atropinle (asetilkolin döngüsünü uyarmak için) veya hemikolinium-3 (kolinin yüksek afinite tanmasn engellemek için) ile muamelesi, [(2) H6] Dimethyl Ethanol Amine (Dimetil Etanol Amine) ‘in asetilkolin sentezi üzerinde herhangi bir etki göstermedi. vivo. Bununla birlikte, [(2) H6] Dimethyl Ethanol Amine (Dimetil Etanol Amine) beyin kolini arttrdndan, kolin üretimi azaldnda veya asetilkolin sentezi için kolin kullanm bozulduunda terapötik açdan faydal olabilir.2- Dimetilaminoetanol (DMAE) (Dimethyl Ethanol Amine (Dimetil Etanol Amine) olarak da bilinir) cilt bakmnda ve bilisel ilev ve duygudurum gelitirici ürünlerde bir bileen olarak kullanlmtr. Dimethyl Ethanol Amine (Dimetil Etanol Amine) ACETAMIDOBENZOATE / WHICH / 2- (DMETHYLAMINO) ETANOL’UN (Dimethyl Ethanol Amine (Dimetil Etanol Amine)) P-ASETAMDOBENZOK AST TUZUDUR. / Dimethyl Ethanol Amine (Dimetil Etanol Amine) ACETAMIDOBENZOATE / 2-Dimetilaminoetanol (DMAE) (ayrca Dimethyl Ethanol Amine (Dimetil Etanol Amine) olarak da bilinir) cilt bakmnda ve bilisel ilev ve duygudurum artrc ürünlerde bir bileen olarak kullanlmtr. . Serbest baz veya tuz olarak pazarlanmaktadr ve teoride, iki form eit derecede etkili olmal ve farmasötik formülasyonlarda birbirinin yerine geçebilmelidir.Dimethyl Ethanol Amine (Dimetil Etanol Amine) ve ayn anda belirlenmesi için bir yöntem açklanmtr. biyolojik örneklerde kolin. Karlatrma, 100 ° C’de GC 22, 100/200 ada% 5 ddts,% 5 ov-101 ile paketlenmi bir silanize cam kolon kullanlarak gaz kromatografisi-kütle spektrometresi ile ölçüldü. Dokuda Dimethyl Ethanol Amine (Dimetil Etanol Amine) tayini Gaz kromatografisi ile. in vivo sçanlarda tiokarb ve (+) – siyanidanol-3 ile parasetamol kaynakl karacier hasarn önledi. Hem, hem de dier iki antihepatotoksik ajan, Dimethyl Ethanol Amine (Dimetil Etanol Amine) ve DMSO, [(3) H] -parasetamolün in vitro sçan karacier mikrozomal proteinlerine kovalent balanmasn inhibe etti. Ditiokarb ve (+) – siyanidanol-3 en etkili inhibitörlerdi. % 50 inhibisyon (I50) veren antidotlarn konsantrasyonlar ditiyokarb için 1.8 x 10 (-5) M ve (+) – siyanidanol-3 için 2.1 x 10 (-5) M deerindedir. Daha büyük dozlar uykusuzluk, kas gerginlii ve spontan kas seirmeleri. Dimethyl Ethanol Amine (Dimetil Etanol Amine) alan, geç diskinezi olan 37 yandaki bir kadnda ciddi kolinerjik yan etkiler bildirilmitir. Mevcut 2-fazl randomize çift kör bölünmü yüz çalmas,% 3 2-dimetilaminoetanol (Dimethyl Ethanol Amine (Dimetil Etanol Amine), DMAE) içeren bir jelin etkisini DMAE içermeyen ayn formülasyon ile karlatrmak için tasarlanmtr. Yalanan cildin iyiletirilmesi için cilt bakm formülasyonlar giderek daha önemli eksilerdirumer ürünleri. Burada, yakn zamanda plasebo kontrollü bir aratrmada deerlendirilen bu tür bir ajan – 2-dimetilaminoetanol (DMAE) veya Dimethyl Ethanol Amine (Dimetil Etanol Amine) – hakkndaki mevcut verileri gözden geçiriyoruz. hiperaktiviteye sahip olanlarn çou nörolojik veya psikiyatrik hastalk için tarand, ardndan 3 ay boyunca çift kör bir ekilde Dimethyl Ethanol Amine (Dimetil Etanol Amine), metilfenidat veya plasebo verildi. Metilfenidat için idame dozu günlük 40 mg idi; Dimethyl Ethanol Amine (Dimetil Etanol Amine) için, 500 mg. Tedaviden önce ve sonra davran derecelendirme formlar, reaksiyon süresi ve bir dizi standart psikometrik test verildi. Her iki ilaç da bir dizi testte önemli gelime gösterdi; model ve deiim derecesi 2 için biraz farklyd. Bu paradigmada, Dimethyl Ethanol Amine (Dimetil Etanol Amine) örenme ve davran bozukluu olan çocuklarda performans artrd görülmütür. Etki mekanizmas spekülatif kalr; Dimetil Etanol Amin’in (Dimetil Etanol Amin) asetilkolini artrdnn kant yetersizdir ve antikolinerjik bir etkiyi varsaymann teorik bir temeli vardr.