ERYTHORBIC ACID (ERTORBK AST)

CAS No. : 89-65-6

EC No. : 201-928-0

Synonyms:Erythorbic Acid; Eritorbik Asit; Erythorbicacid; Erythrobic acid; Erythorbic; Acid; Eritrobik asit; Eritrobikasit; Eritorbic asit; Eriytorbik asit; D-(-)-Isoascorbic acid;izo askorbik asit, izoaskorbik asit, Izoaskorbikasit; Izoaskorbik asit; Iso askorbik asit; Izo askorbik asit; Izo askorbikasit; izoaskorbikasit,isoaskorbik asit, iso askorbik asit, isoaskorbik asit; D-erythro-Hex-2-enoic acid ?-lactone; Erythroascorbic acid; D-(-)-Isoascorbic acid D-Araboascorbic acid; Erythorbic acid; Glucosaccharonic acid; NSC 8117; Araboascorbic acid; D-; Isoascorbic Acid; Erythorbic acid; 89-65-6; D-Araboascorbic acid; Araboascorbic acid; D-Erythorbic acid; Isovitamin C; Neo-cebicure; Saccharosonic acid; Mercate 5; Glucosaccharonic acid; Erythroascorbic acid, D-; D-(-)-Isoascorbic acid; FEMA Number: 2410; 2,3-Didehydro-D-erythro-hexono-1,4-lactone; D-ASCORBIC ACID, ISO; Erycorbin; FEMA No. 2410; CCRIS 6568; HSDB 584; UNII-311332OII1; D-erythro-Hex-2-enonic acid, gamma-lactone; NSC 8117; D-erythro-3-Oxohexonic acid lactone; EINECS 201-928-0; D-erythro-3-Ketohexonic acid lactone; MFCD00005378; (5R)-5-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one; (R)-5-((R)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one; 3-Oxohexonic acid lactone, D-erythro-; BRN 0084271; D-erythro-hex-2-enonic acid gamma-lactone; 3-Keto-D-erythro-hexonic acid gamma-lactone; CHEBI:51438; CIWBSHSKHKDKBQ-DUZGATOHSA-N; D-erythro-hex-2-enono-1,4-lactone; 311332OII1; E315; D-Erythro-hex-2-enonic acid, gamma-lactone,; D(-)-Isoascorbic acid, 98%; D-erythro-Hex-2-enonic acid, .gamma.-lactone; erythroascorbic acid; Erythorbic acid [NF]; Erythorbatd; D-Isoascorbicacid ercate5;NSC 8117;FEMA 2410;ERYCORBIN;D-(-mercate”5″;)-Isoascor;NEOCEBICURE;ERYTHORBATE;ISOVITAMIN C; D-(-)-Isoascorbic acid, D-erythro-Hex-2-enoic acid ?-lactone, D-Araboascorbic acid, Erythorbic acid, Glucosaccharonic acid, NSC 8117 Araboascorbic acid; d-Araboascorbic acid; D-2,3-didehydro-erythro-hexono-1,4-lactone; E315; Erycorbin; Erythorbic acid; d-Erythorbic acid; d-Erythro-ascorbic acid D-Erythro-hex-2-enoic acid; D-erythro-Hex-2-enonic acid, .gamma.-lactone; D-Erythro-3-ketohexonic acid lactone; D-Erythro-3-oxohexonic acid lactone; FEMA Number: 2410 Glucosaccharonic acid; Isoascorbic acid; D-Isoascorbic acid; Isovitamin C; gamma-Lactone; Mercate 5; Neo-cebicure; Saccharosonic acid; D-araboascorbic acid; erythorbic acid erythroascorbic acid; isoascorbic acid; isoascorbic acid, disodium salt; isoascorbic acid, monosodium salt; isoascorbic acid, sodium salt; sodium erythorbate; Erythorbic acid Isoascorbic acid; D-Isoascorbic acid; 89-65-6; D-Araboascorbic acid; Araboascorbic acid; D-Erythorbic acid; Isovitamin C; Neo-cebicure; Saccharosonic acid; Mercate 5 Glucosaccharonic acid; Erythroascorbic acid; D-(-)-Isoascorbic acid; FEMA Number: 2410; 2,3-Didehydro-D-erythro-hexono-1,4-lactone; D-ASCORBIC ACID, ISO; Erycorbin; FEMA No. 2410 CCRIS 6568; HSDB 584; UNII-311332OII1; D-erythro-Hex-2-enonic acid, gamma-lactone; NSC 8117; D-erythro-3-Oxohexonic acid lactone; EINECS 201-928-0; D-erythro-3-Ketohexonic acid lactone MFCD00005378; (5R)-5-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one; (R)-5-((R)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one; 3-Oxohexonic acid lactone, D-erythro- BRN 0084271; D-erythro-hex-2-enonic acid gamma-lactone; 3-Keto-D-erythro-hexonic acid gamma-lactone; Hex-2-enonic acid gamma-lactone, D-erythro-; CHEBI:51438; CIWBSHSKHKDKBQ-DUZGATOHSA-N D-erythro-hex-2-enono-1,4-lactone; 311332OII1; E315; D-Erythro-hex-2-enonic acid, gamma-lactone,; D(-)-Isoascorbic acid, 98%; D-erythro-Hex-2-enonic acid, .gamma.-lactone erythroascorbic acid; Erythorbic acid [NF]; Erythorbatd; D-Isoascorbicacid; 1f9g; AC1L1NQG; DSSTox_CID_6537; D-(-)-Araboascorbic acid; EC 201-928-0; DSSTox_RID_78143 DSSTox_GSID_26537; SCHEMBL18678; 5-18-05-00026 (Beilstein Handbook Reference); CHEMBL486293; SCHEMBL3700961; DTXSID6026537; D-(-)-Isoascorbic acid, 98%; KS-00000UH8 Tox21_201111; SBB017515; AKOS015856346; ZINC100006772; ZINC100057602; LS-2352; RL05634; CAS-89-65-6; D-erythro-Hex-2-enonic acid, g-lactone; NCGC00258663-01; D-erythro-Hex-2-enoic acid gamma-lactone D-Isoascorbic acid, >=99%, FCC, FG; O272; A0520; FT-0624450; C20364; J-506944; (2R)-2-[(1R)-1,2-dihydroxyethyl]-4,5-dihydroxyfuran-3-one; 7179C406-7CCF 4C07-9125-AA71E28FB983 (2R)-2-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one; (5R)-5-(1,2-dihydroxyethyl)-3,4-dihydroxy-5-hydrofuran-2-one; Erythorbic acid, United States Pharmacopeia (USP) Reference Standard (5R)-5-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxy-2,5-dihydrofuran-2-one; D-Isoascorbic acid(Erythorbic acid) CAS 89-65-6; Erythorbic acid or erythorbate, formerly known Other name: D-erythro-Hexonicacid, 3-keto-, g-lactone(6CI);Erythorbic acid (7CI);Araboascorbic acid; Araboascorbic acid, D-;D-(-)-Isoascorbic acid;D-Araboascorbic acid; D-Erythorbic acid;D-Isoascorbicacid;D-arabino-Ascorbic acid;Glucosaccharonic acid;Isoascorbic acid;Isovitamin C;Saccharosonic acid

Erythorbic Acid (Eritorbik Asit) IUPAC Name (2R)-2-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one

Erythorbic Acid (Eritorbik Asit) InChI InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5-/m1/s1

Erythorbic Acid (Eritorbik Asit) InChI Key CIWBSHSKHKDKBQ-DUZGATOHSA-N

Erythorbic Acid (Eritorbik Asit) Canonical SMILES C(C(C1C(=C(C(=O)O1)O)O)O)O

Erythorbic Acid (Eritorbik Asit) Isomeric SMILES C([C@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O

Erythorbic Acid (Eritorbik Asit) Molecular Formula C6H8O6

Erythorbic Acid (Eritorbik Asit) CAS 89-65-6

Erythorbic Acid (Eritorbik Asit) Deprecated CAS 74242-57-2, 98966-42-8

Erythorbic Acid (Eritorbik Asit) European Community (EC) Number 201-928-0

Erythorbic Acid (Eritorbik Asit) UNII 311332OII1

Erythorbic Acid (Eritorbik Asit) FEMA Number 2410

Erythorbic Acid (Eritorbik Asit) DSSTox Substance ID DTXSID6026537

Erythorbic Acid (Eritorbik Asit) Physical Description DryPowder; OtherSolid; PelletsLargeCrystals

Erythorbic Acid (Eritorbik Asit) Color/Form Shiny granular crystals from water or dioxane

Erythorbic Acid (Eritorbik Asit) Melting Point About 164 °C to 172 °C with decomposition

Erythorbic Acid (Eritorbik Asit) Solubility Soluble in alcohol, pyridine; moderately soluble in acetone; slightly soluble in glycerol

Erythorbic Acid (Eritorbik Asit) Vapor Pressure 1.54X10-10 mm Hg at 25 °C (est)

Erythorbic Acid (Eritorbik Asit) LogP log Kow = -1.88 (est)

Erythorbic Acid (Eritorbik Asit) Optical Rotation [α]D/25 10 % (w/v) aqueous solution between – 16,5° to – 18,0°

Erythorbic Acid (Eritorbik Asit) Decomposition When heated to decomposition it emits acrid smoke and irritating fumes.

Erythorbic Acid (Eritorbik Asit) Biological Half-Life In dogs, this resulted in a half-life of approximately 30 minutes for erythorbic acid in the plasma.

Erythorbic Acid (Eritorbik Asit) Use Classification Food additives

Erythorbic Acid (Eritorbik Asit) Molecular Weight 176.12 g/mol

Erythorbic Acid (Eritorbik Asit) XLogP3 -1.6

Erythorbic Acid (Eritorbik Asit) Hydrogen Bond Donor Count 4

Erythorbic Acid (Eritorbik Asit) Hydrogen Bond Acceptor Count 6

Erythorbic Acid (Eritorbik Asit) Rotatable Bond Count 2

Erythorbic Acid (Eritorbik Asit) Exact Mass 176.032088 g/mol

Erythorbic Acid (Eritorbik Asit) Monoisotopic Mass 176.032088 g/mol

Erythorbic Acid (Eritorbik Asit) Topological Polar Surface Area 107 Å²

Erythorbic Acid (Eritorbik Asit) Heavy Atom Count 12

Erythorbic Acid (Eritorbik Asit) Formal Charge 0

Erythorbic Acid (Eritorbik Asit) Complexity 232

Erythorbic Acid (Eritorbik Asit) Isotope Atom Count 0

Erythorbic Acid (Eritorbik Asit) Defined Atom Stereocenter Count 2

Erythorbic Acid (Eritorbik Asit) Undefined Atom Stereocenter Count 0

Erythorbic Acid (Eritorbik Asit) Defined Bond Stereocenter Count 0

Erythorbic Acid (Eritorbik Asit) Undefined Bond Stereocenter Count 0

Erythorbic Acid (Eritorbik Asit) Covalently-Bonded Unit Count 1

Erythorbic Acid (Eritorbik Asit) Compound Is Canonicalized Yes

Erythorbic acid (isoascorbic acid, d-araboascorbic acid) is a stereoisomer of ascorbic acid (vitamin C).[1] It is synthesized by a reaction between methyl 2-keto-d-gluconate and sodium methoxide. It can also be synthesized from sucrose or by strains of Penicillium that have been selected for this feature.[2] It is denoted by E number E315, and is widely used as an antioxidant in processed foods.Clinical trials have been conducted to investigate aspects of the nutritional value of erythorbic acid. One such trial investigated the effects of erythorbic acid on vitamin C metabolism in young women; no effect on vitamin C uptake or clearance from the body was found.[4] A later study found that erythorbic acid is a potent enhancer of nonheme-iron absorption.Since the U.S. Food and Drug Administration banned the use of sulfites as a preservative in foods intended to be eaten fresh (such as salad bar ingredients), the use of erythorbic acid as a food preservative has increased.It is also used as a preservative in cured meats and frozen vegetables.It was first synthesized in 1933 by the German chemists Kurt Maurer and Bruno Schiedt.Erythorbic acid or erythorbate, formerly known as iso ascorbic acid and D-arabo ascorbic acid, is a stereoisomer of ascorbic acid.Erythorbic acid or erythorbate, formerly known as iso ascorbic acid and D-arabo ascorbic acid, is a stereoisomer of ascorbic acid.And its chemical properties have many similarities with Vc, but as an antioxidant, it has the inimitable advantage that Vc do not have: First, it is superior to the anti-oxidation than Vc, therefore, mixed the Vc, it can effectively protect the properties Vc component in improving the properties have very good results, while protecting the Vc color. Second, higher security, no residue in the human body, participating in metabolism after absorb by human body, which can be transformed into Vc partially. In recent years, Chinese medicine take it as complementary information be used in Vc film, Vc Yinqiao-Vc and health care products, and obtain good effect. Specification: 99%min Other name: D-erythro-Hexonicacid, 3-keto-, g-lactone(6CI);Erythorbic acid (7CI);Araboascorbic acid; Araboascorbic acid, D-;D-(-)-Isoascorbic acid;D-Araboascorbic acid;D-Erythorbic acid;D-Isoascorbicacid;D-arabino-Ascorbic acid;Glucosaccharonic acid;Isoascorbic acid;Isovitamin C;Saccharosonic acid.Erythorbic acid is produced in acidic condition by sodium erythorbate.Erythorbic acid has strong reducing action and has effects on reducing blood press, diuresis,generationg liver glycogen,excreting pigment,detoxifying the body.Erythorbic acid, an epimer of L-ascorbic acid, is used in the United States as a food additive. Studies were conducted to determine whether the ingestion of erythorbic acid in the diet had any beneficial or adverse effects on the human requirement for vitamin C. Young women were fed diets that contained controlled amounts of erythorbic acid and ascorbic acid. In pharmacokinetic evaluations, erythorbic acid and ascorbic acid were rapidly absorbed with little interaction. Erythorbic acid cleared from the body more rapidly than ascorbic acid. Some subjects received diets deficient in vitamin C for periods < or = 30 d. Increasing intakes of erythorbic acid or prolonged intakes of < or = 1 g erythorbic acid/d did not indicate any interactions with ascorbic acid. Consumption of erythorbic acid resulted in the presence of erythorbic acid in mononuclear leukocytes. Ascorbic acid concentrations in these cells were not affected by the presence of erythorbic acid. Erythorbic acid disappeared quickly from these cells with cessation of erythorbic acid supplements. Prolonged ingestion of erythrobic acid by young women neither antagonized nor spared their vitamin C status.

How is Erythorbic Acid made?

It can be produced by a reaction between methyl 2-keto-D-gluconate and sulphuric acid.

Generally, the manufacturing process has 5 steps:

Producing calcium 2-keto-D-gluconate: food-grade starch hydrolysate fermentation by Pseudomonas fluorescens with calcium carbonate.

Acidify the above fermentation broth to obtain 2-keto-D-gluconic acid (2-KG).

Esterification 2-KG with methanol under acid conditions to yield methyl 2-keto-D-gluconate.

The synthesis of sodium erythorbate: heating the above suspension with sodium bicarbonate or sodium carbonate.

The reaction between sodium erythorbate and sulphuric acid.

It can significantly reduce the production of nitrosamines if the combination uses of erythorbic acid with nitrite.At the same time, it can stabilize the color of meat.It was reported by Mintel GNDP that nearly 5,000 products out of nearly 1 million products sold in Europe contain erythorbic acid or sodium erythorbate in meat products or products contained meat as an ingredient (e.g. pizza, ready-to-eat meat meals, meat-based spread and filled pasta).Erythorbic acid and its sodium salt can be used as an antioxidant in beverages, beer and etc. It can eliminate the discoloration, odor and turbidity, and improve the poor taste of beverages. In beer, it can remove the stale odor, enhance flavor stability, and prolong its shelf life.

What are the possible Side Effects?

It is common that sometimes consumers have questions whether erythorbic acid is bad for our health and what are the side effects in the food we eat. However, it is generally considered safe and almost no reported health risks. Maybe some people are allergic or sensitive to it.

Erythorbic acid is readily absorbed and metabolized.Following an oral dose of 500 mg of erythorbic acid to human subjects the blood level curves for ascorbic acid and erythorbic acid showed a similar rise. In five human subjects, an oral dose of 300 mg was shown to have no effect on urinary excretion of ascorbic acid.Erythorbic acid was found to have no antagonistic effect on the action of ascorbic acid.

When guinea pigs on a low ascorbate diet were given a supplement of ascorbic acid or erythorbic acid at daily doses of 1.5 mg/kg b.w., ascorbic acid was deposited in the tissues while erythorbic acid was not. Intramuscularly administered erythorbic acid was not retained in the tissues to the same extent as a similar dose of ascorbic acid. The authors concluded that ascorbic acid is more readily absorbed from the gastro-intestinal tract and more readily abstracted from the blood and/or retained by the tissues than is erythorbic acid (Hughes & Hurley, 1969). When ascorbic acid or erythorbic acid were administered in drinking water at doses of 180 mg/1, tissue levels of ascorbate were higher than erythorbate in the tissues examined (spleen, adrenals, brain and eye lens). The ratio of ascorbate: erythorbate concentrations achieved varied from 8:1 in the spleen to 2.8:1 in the brain. At higher concentrations of 1% in drinking water, higher tissue levels of either ascorbate or erythorbate were found and differences in tissue concentrations between the two substances was reduced, the ratio varying from 1.7:1 in spleen to 1.1:1 in brain. It was concluded that the differences arose from the lower absorption efficiency of erythorbic acid and that this was partially overcome when higher concentrations were given in drinking water rather than as a single supplement (Hughes & Jones, 1970). It appears that in these high concentration conditions, the active absorption mechanism for ascorbic acid might have been approaching saturation with much of the dose of both compounds being absorbed by passive diffusion.

The erythorbic acid content of the tissues (liver, adrenals,kidneys and spleen) of guinea pigs was compared with that of ascorbic acid after oral administration of the compounds at doses of 1, 5, 20 (erythorbic only) and 100 mg/day for 16 days. Only a small amount of erythorbic acid was found in the four organs of animals given 20 mg or more of erythorbic acid; conversely, ascorbic acid was detected in the tissues of animals from all dose groups. Even at the highest dose, much less erythorbic acid was retained in these tissues than ascorbic acid (Suzuki et al., 1987).

Guinea-pigs were fed diets containing either 2% erythorbic acid or 0.1% ascorbic acid for a period of 9 days followed by a depletion period of 4 days during which they received an ascorbic acid-deficient diet. At the end of the 9 day period, tissue levels of erythorbic acid were about twice those of ascorbic acid, despite the 20-fold difference in dose. After the 4-day depletion period,erythorbate levels were much lower than the ascorbate concentrations in all the tissues examined except the adrenals. From the calculated turnover rates, the t1/2 was estimated to be 4-5 times shorter for erythorbic acid than for ascorbic acid in all the organs viz: brain, liver, heart, kidneys, adrenals and spleen.Furthermore, erythorbic acid increased rather than decreased the turnover of ascorbic acid (Pelletier, 1969b).

There are significant differences between ascorbic and erythorbic acids in renal excretion in humans. Studies in vitamin C-depleted humans indicated that the rate and extent of urinary excretion of erythorbic acid are much greater than those of ascorbic acid. At oral doses of 50-300 mg per person about 50-70% of the dose of erythorbic acid was excreted in 24 hour urine (mainly in the first 6 hours) but only 15% of a 100 mg dose of ascorbic acid appeared in urine; the rate of urinary excretion of erythorbic acid was 10-15 times that of ascorbic acid. (Ikeuchi 1955). Similar results have been obtained in later studies in humans (Wang et al., 1962; Rivers et al., 1963).

In guinea pigs receiving daily doses of ascorbic acid (2 mg/d) or erythorbic acid (40 mg/d) the 12h urinary excretion of these two compounds was found to be 0.13% and 1.9% of the daily dose respectively at the end of the experiment. No further metabolites of erythorbic acid were identified although the authors pointed out that as so little was incorporated into organs it would be of interest to determine how it is metabolized (Pelletier & Godin,1969).

Erythorbic acid is a stereoisomer of ascorbic acid (Vitamin C). While ascorbic acid is allowed as a synthetic ingredient in or on processed organic products at §205.605 in the NOP regulations, the issue of stereoisomers is not addressed in the rule. A stereoisomer is a molecule that has the same formula and sequence of bonded atoms as another, but differs in its three-dimensional orientation. For example, if your hands were molecules and your palm and digits atoms, your left hand would be a stereoisomer of your right. Both ascorbic acid and erythorbic acid are commonly used as anti-oxidant preservatives in a wide variety of foods. The use of erythorbic acid as a preservative in foods intended to be eaten raw has increased since the US FDA banned the use of sulfites for this purpose.Since the NOSB did not specifically discuss erythorbic acid during its Technical Advisory Panel (TAP) reviews for Ascorbic acid, the real question is whether or not erythorbic acid is chemically the same as ascorbic acid. The materials have different CAS registry numbers, and this is an indication that they are distinct chemicals. One does not fall under the identity of the other, according to the American Chemical Society.While studies show that natural and synthetic ascorbic acid behave similarly in biologic systems, stereoisomers of ascorbic acid show a decreased anti-ascorbutic activity in comparison. This is a clear indication that the materials are functionally different in metabolic systems, at least in degree.OMRI consequently regards the two materials as chemically and functionally distinct, and does not consider erythorbic acid to be included in the allowance of ascorbic acid for organic processing. Those wishing to use the ingredient in organic processing would be encouraged to petition the NOP to have erythorbic acid specifically addressed.

Background: Erythorbic acid, a stereoisomer of ascorbic acid with similar physicochemical properties, is widely used as an antioxidant in processed foods.

Objectives: The aims of the present study were to evaluate the effect of erythorbic acid on iron absorption from ferrous sulfate at molar ratios of 2:1 and 4:1 (relative to iron) and to compare the effect of erythorbic acid directly with that of ascorbic acid at a molar ratio of 4:1.

Design: Iron absorption from iron-fortified cereal was measured in 10 women on the basis of erythrocyte incorporation of stable iron isotopes (57Fe or 58Fe) 14 d after administration. Each woman consumed 4 ferrous-sulfate-fortified test meals (containing 5 mg Fe/meal) with or without added erythorbic or ascorbic acid. The data were evaluated by use of paired t tests, and the results are presented as geometric means.

Results: Iron absorption from the test meal without any added enhancer was 4.1%. The addition of erythorbic acid (at molar ratios of 2:1 and 4:1 relative to iron) increased iron absorption 2.6-fold (10.8%; P < 0.0001) and 4.6-fold (18.8%; P < 0.0001), respectively. The addition of ascorbic acid (molar ratio of 4:1) increased iron absorption 2.9-fold (11.7%; P = 0.0004). At a molar ratio of 4:1, erythorbic acid was 1.6-fold (P = 0.0002) as potent an enhancer of iron absorption as was ascorbic acid.

Conclusion: Although erythorbic acid is a potent enhancer of iron absorption, its lack of antiscorbutic activity limits its usefulness in iron-fortification programs. However, it may play a major role in enhancing iron bioavailability from mixed diets that include foods preserved with erythorbic acid.

Functions and Applications

1.Erythorbic acid is produced in acidic condition by sodium erythorbate.

2.Erythorbic acid has strong reducing action and has effects on reducing blood press, diuresis,generationg liver glycogen,excreting pigment,detoxifying the body.

3.It is non-toxic.Its other applications are familiar to sodium erythorbate. Sodium erythorbateand erythorbic acid are generally recognized as the lastest A-class

Green products internationally and have become the commodities in short supply both at home and abroad

Erythorbic acid

United States Pharmacopeia (USP) Reference Standard

Synonym: D-(-)-Isoascorbic acid, D-erythro-Hex-2-enoic acid ?-lactone, D-Araboascorbic acid, Erythorbic acid, Glucosaccharonic acid, NSC 8117 CAS Number 89-65-6

Empirical Formula (Hill Notation) C6H8O6 Molecular Weight 176.12 Beilstein Registry Number 84271 MDL number MFCD00005378 Substance ID 329749380

Erythorbic acid United States Pharmacopeia (USP) Reference Standard SDS Similar Products SKU-Pack Size Availability Price (EUR) 1241823-50MG Estimated to ship on

14.08.19 407.00 To order products, please contact your local dealer. Click here Product Recommendations W241008 D-Isoascorbic acid FCC, FG 856061 D-(-)-

Isoascorbic acid 98% 496332 Sodium D-isoascorbate monohydrate 97% top Purchase Safety & Documentation Properties Related Categories Analytical Standards,

Erythorbate, Isoascorbic acid. Identifiers CAS Number 89-65-6 ? 3D model (JSmol) Interactive image ChEBI CHEBI:51438 ? ChemSpider 16736142 ? ECHA InfoCard 100.001.753

E number E315 (antioxidants, …) CID 6981 UNII 311332OII1 ? CompTox Dashboard (EPA) DTXSID6026537 Edit this at Wikidata InChI

verify (what is ?? ?) Infobox references Erythorbic acid (isoascorbic acid, D-araboascorbic acid) is a stereoisomer of ascorbic acid (vitamin C).[1] It is synthesized by a reaction between methyl 2-keto-D-gluconate and sodium methoxide. It can also be synthesized from sucrose or by strains of Penicillium that have been selected for this feature.[2] It is denoted by E number E315, and is widely used as an antioxidant in processed foods.[3]

/OTHER TOXICITY INFORMATION/ At the last evaluation an /Acceptable Daily Intake/ (ADI) of 0-5 mg/kg bw was allocated based on a long-term study in the rat. The present /Joint FAO/WHO Expert Committee on Food Additives/ reviewed new toxicological studies on isoascorbic acid and its sodium salt, and metabolic and nutritional studies of the interactions with ascorbic acid.

The reduced form of erythorbic acid was incorporated into human erythrocytes at the rate of 20% per 2 hours and the rate of uptake of this form was proportional to the extracellular concentration. The oxidized form of erythorbic acid, D-dehydroisoascorbic acid, became incorporated more rapidly than the reduced form, at a rate of 50% per 5 minutes, and 80% of the acid absorbed was subsequently reduced within the cells. The reduced form of erythorbic acid was more stable in plasma than the oxidized form, of which 61% was degraded in 60 minutes. In erythrocytes, the reduced form was stable, as in plasma, and the oxidized form slightly less so.Biological Half-Life:

In dogs, this resulted in a half-life of approximately 30 minutes for erythorbic acid in the plasma.

[Cosmetic Ingredient Expert Review Panel; Final Report on the Safety Assessment of Ascorbyl Palmitate, Ascorbyl Dipalmitate, Ascorbyl Stearate, Erythorbic Acid, and Sodium Erythorbate; International Journal of Toxicology 18 ( Suppl 3): 1-26 (1999).] **PEER REVIEWED**

Interactions:

The modifying effects of 3 antioxidants, sodium L-ascorbate (SA), ascorbic acid (AA) and sodium erythorbate (SE) on two-stage gastric carcinogenesis in F344 rats initiated with N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) were investigated. Administration of 5% SE in the diet significantly decreased the incidence of dysplasia of the pylorus and, more marginally the incidence of papilloma of the forestomach, whereas administration of 5% and 1% SA and 5% AA in the diet was not associated with effect. These results suggest that SE exerts a weak inhibitory effect on gastric carcinogenesis. /Sodium erythorbate/The marked azotemia & other evidence of renal damage induced in rats & dogs by rapid iv admin of tetracycline-HCl (50 mg/kg) was prevented by concomitant admin of ascorbic acid (125 mg/kg or more). D-isoascorbic acid had a similar effect when tested in rats.

Pharmacology:

Therapeutic Uses:Erythorbic acid is a stereoisomer of l-ascorbic acid, and is used as an antioxidant in foods and oral pharmaceutical formulations. It has approximately 5% of the vitamin C activity of l-ascorbic acid.

Interactions:The modifying effects of 3 antioxidants, sodium L-ascorbate (SA), ascorbic acid (AA) and sodium erythorbate (SE) on two-stage gastric carcinogenesis in F344 rats initiated with N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) were investigated. Administration of 5% SE in the diet significantly decreased the incidence of dysplasia of the pylorus and, more marginally the incidence of papilloma of the forestomach, whereas administration of 5% and 1% SA and 5% AA in the diet was not associated with effect. These results suggest that SE exerts a weak inhibitory effect on gastric carcinogenesis. /Sodium erythorbate/ The marked azotemia & other evidence of renal damage induced in rats & dogs by rapid iv admin of tetracycline-HCl (50 mg/kg) was prevented by concomitant admin of ascorbic acid (125 mg/kg or more). D-isoascorbic acid had a similar effect when tested in rats.Scorbutic (low collagen) granulomas were induced by s.c. injection of carrageenan to vitamin C-deficient male guinea pigs.Isoascorbic acid and ascorbic acid (6 doses of 100 mg i.p. at 12 hours intervals) were similarly effective in restoring collagen synthesis in the granuloma although the concentration of erythorbic acid 12 hours after injection was lower than that of ascorbic acid 24 h after injection (Robertson, 1963).(b) in vitro studies

Ascorbic acid and erythorbic acid demonstrated similar activity in promoting the hydroxylation of peptidyl proline in a cell-free system (Hutton et al., 1967; Kutnink et al., 1969) and these observations have been confirmed using a purified prolyl 4- dihydroxylase preparation.Erythorbic acid had a similar effect to ascorbic acid in protecting hepatic microsomal UDP-glucuronyltransferase activity towards p-aminophenol against excess substrate but no protection was afforded by ascorbate-2-sulfate or alpha-tocopherol.The effects of ascorbate and erythorbate on collagen synthesis were studied in cultured human skin fibroblasts. At concentrations of 0.25 mM in the culture medium both ascorbate and erythorbate increased collagen synthesis about eightfold with no significant change in synthesis of non-collagen protein. Lysyl hydroxylase activity increased 3-fold in response to ascorbate or erythorbate administration. After prolonged exposure of cells to ascorbate or erythorbate, prolyl hydroxylase activity was decreased to a similar extent. The results were taken to indicate that collagen polypeptide synthesis, posttranslational hydroxylations and activities of the two hydroxylases are independently regulated by ascorbate, with erythorbate having similar effects at the high concentrations used (Murad et al., 1981). In further studies using human skin fibroblasts, ascorbate stimulated the rate of incorporation of labelled proline into total collagenase-sensitive protein without changing the specific activity of intracellular free proline. The effect of ascorbate was maximal at a concentration of 30 µM and resulted in a four-fold increase of incorporation. Erythorbate also stimulated collagen synthesis but at considerably higher concentrations of 250-300 µM. The stimulation of collagen synthesis by ascorbate and erythorbate was accompanied by a decline in prolyl hydroxylase activity and a rise in lysyl hydroxylase activity; again ascorbate was the more effective (Murad et al., 1983). The protective effects of ascorbic and erythorbic acid against carbon tetrachloride-induced lipid peroxidation were investigated in guinea pigs using exhalation of pentane and ethane as an index of in vivo lipid peroxidation. It was observed that equal doses (750 mg/kg b.w., i.p.) of ascorbic acid or isoascorbic acid provided the same degree of protection for a period of at least 4 hours (Kunert & Tappel, 1983). The authors concluded that the antioxidant function of ascorbic acid is relatively non-specific and that the two stereoisomers do not differ with regard to their antioxidant properties in vivo.

2.3 Observations in humans

In order to determine whether erythorbic acid could displace ascorbic acid from the tissue, urinary levels of ascorbic acid were measured after ingestion of 300 mg erythorbic acid by 5 healthy human volunteers who had been previously repleted by administration of 500 mg ascorbic acid for 7 days. Urinary analyses indicated that ascorbic acid excretion was not affected by treatment with erythorbic acid and that there was no significant displacement of ascorbic acid from tissues (Kadin & Osadca, 1959).The influence of erythorbic acid on ascorbic acid metabolism and status was investigated in 11 healthy, non-pregnant women volunteers. The volunteers were maintained in a metabolic unit and fed a formula diet devoid of vitamin C for 54 days. After depletion of 24 days, the subjects received increasing supplements of ascorbic acid (30 mg/d, 60 mg/d and 90 mg/d for successive periods of 10 days) in the presence or absence of 600 mg/d of erythorbic acid.The depletion resulted in a marked decrease in ascorbic acid in all blood indices and during the study some subjects developed signs of scurvy. Ascorbic acid supplements of 30 mg/d for 10 days failed to increase plasma ascorbate concentrations; 60 mg for 10 days caused a small increase and 90 mg/d resulted in a mean ascorbic acid concentration of 29 mmol/l. Erythorbic acid did not cause any adverse effects but rather had a small ascorbic acid-sparing effect.

3. COMMENTS

At the last evaluation an ADI of 0-5 mg/kg b.w. was allocated based on a long-term study in the rat. The present Committee reviewed new toxicological studies on isoascorbic acid and its sodium salt, and metabolic and nutritional studies of the interactions with ascorbic acid.

Erythorbic Acid(Eritorbik Asit)

Also known as Isoascoribic acid, erythoribic acid is a natural product, vegetable derived food additive produced from sucrose. Erythoribic acid is an important antioxidant in the food industry, which can keep the color, natural flavor of foods and lengthen food storage without toxic and side effects. Erythoribic acid is used in cured meat processing, frozen fruits, frozen vegetables, jams, and in the beverage industry such as beer, grape wine, soft drink, fruit juice and fruit teas. Erythoribic acid’s use has increased tremendously ever since the U.S. Food and Drug Administration banned the use of sulfites as a preservative in foods to be eaten fresh (ie: salad bar ingredients).

Packaging: 25 kg Carton

Erythorbic Acid(Eritorbik Asit) (isoascorbic acid, D-araboascorbic acid) is a stereoisomer of ascorbic acid (vitamin C). It is synthesized by a reaction between methyl 2-keto-D-gluconate and sodium methoxide. It can also be synthesized from sucrose or by strains of Penicillium that have been selected for this feature. It is denoted by E number E315, and is widely used as an antioxidant in processed foods.Clinical trials have been conducted to investigate aspects of the nutritional value of Erythorbic Acid(Eritorbik Asit). One such trial investigated the effects of Erythorbic Acid(Eritorbik Asit) on vitamin C metabolism in young women; no effect on vitamin C uptake or clearance from the body was found. A later study found that Erythorbic Acid(Eritorbik Asit) is a potent enhancer of nonheme-iron absorption.Since the U.S. Food and Drug Administration banned the use of sulfites as a preservative in foods intended to be eaten fresh (such as salad bar ingredients), the use of Erythorbic Acid(Eritorbik Asit) as a food preservative has increased. It is also used as a preservative in cured meats and frozen vegetables.It was first synthesized in 1933 by the German chemists Kurt Maurer and Bruno Schiedt.

Erythorbic Acid(Eritorbik Asit)

Erythorbic Acid(Eritorbik Asit), formerly known as isoascorbic acid and D-araboascorbic acid, is a stereoisomer of ascorbic acid. It is a vegetable-derived food additive produced from sucrose. It is denoted by E number E315, and is widely used as an antioxidant in processed foods. Clinical trials have been conducted to investigate aspects of the nutritional value of Erythorbic Acid(Eritorbik Asit). One such trial investigated the effects of Erythorbic Acid(Eritorbik Asit) on vitamin C metabolism in young women; no effect on vitamin C uptake or clearance from the body was found. A later study found that Erythorbic Acid(Eritorbik Asit) is a potent enhancer of nonheme-iron absorption. Since the U.S. Food and Drug Administration banned the use of sulfites as a preservative in foods intended to be eaten fresh, the use of Erythorbic Acid(Eritorbik Asit) as a food preservative has increased. It is also used as a preservative in cured meats and frozen vegetables.

Erythorbic Acid(Eritorbik Asit) is one of the popular food additives and ingredients in most countries, As a professional Erythorbic Acid(Eritorbik Asit) supplier and manufacturer, Foodchem International Corporation has been supplying and exporting Erythorbic Acid(Eritorbik Asit) from China for almost 10 years, please be assured to buy Erythorbic Acid(Eritorbik Asit) at Foodchem. Any inquiries and problems please feel free to send emails to us via sales@foodchem.cn, we will reply you within 1 working day.

Eritorbik Asit (Erythorbic Acid) IUPAC Ad (2R) -2 – [(1R) -1,2-dihidroksietil] -3,4-dihidroksi-2H-furan-5-on

Eritorbik Asit (Erythorbic Acid) InChI InChI = 1S / C6H8O6 / c7-1-2 (8) 5-3 (9) 4 (10) 6 (11) 12-5 / h2,5,7-10H, 1H2 / t2 -, 5- / m1 / s1

Eritorbik Asit (Erythorbic Acid) InChI Key CIWBSHSKHKDKBQ-DUZGATOHSA-N

Eritorbik Asit (Erythorbic Acid) Kanonik SMILES C (C (C1C (= C (= O) O1) O) O) O) O

Eritorbik Asit (Erythorbic Acid) zomerik SMILES C ([C @ H] ([C @ H] 1C (= C (C (= O) O1) O) O) O) O

Eritorbik Asit (Erythorbic Acid) Moleküler Formül C6H8O6

Eritorbik Asit (Erythorbic Acid) CAS 89-65-6

Eritorbik Asit (Erythorbic Acid) Kullanmdan Kaldrlm CAS 74242-57-2, 98966-42-8

Eritorbik Asit (Erythorbic Acid) Avrupa Topluluu (EC) Numaras 201-928-0

Eritorbik Asit (Erythorbic Acid) UNII 311332OII1

Eritorbik Asit (Erythorbic Acid) FEMA Numaras 2410

Eritorbik Asit (Erythorbic Acid) DSSTox Madde Kimlii DTXSID6026537

Eritorbik Asit (Erythorbic Acid) Fiziksel Tanm Kuru Toz; Dier Kat; PeletlerBüyük Kristaller

Eritorbik Asit (Erythorbic Acid) Renk / Form Su veya dioksan’dan parlak granüler kristaller

Eritorbik Asit (Erythorbic Acid) Erime Noktas Yaklak 164 ° C ila 172 ° C dekompozisyon ile

Eritorbik Asit (Erythorbic Acid) Çözünürlük Alkolde çözünür, piridin; asetonda orta derecede çözünür; gliserolde biraz çözünür

Eritorbik Asit (Erythorbic Acid) Buhar Basnc 25 ° C’de 1.54X10-10 mm Hg (est)

Eritorbik Asit (Erythorbic Acid) LogP log Kow = -1.88 (tahmini)

Eritorbik Asit (Erythorbic Acid) Optik Rotasyon [α] D / 25% 10 (w / v) sulu çözelti – 16,5 ° ile – 18,0 ° arasnda

Eritorbik Asit (Erythorbic Acid) Ayrma Ayrmaya kadar stldnda keskin duman ve tahri edici dumanlar yayar.

Eritorbik Asit (Erythorbic Acid) Biyolojik Yar Ömrü Köpeklerde bu, plazmadaki eritorbik asit için yaklak 30 dakikalk bir yar ömre neden oldu.

Eritorbik Asit (Erythorbic Acid) Kullanm Snflandrmas Gda katk maddeleri

Eritorbik Asit (Erythorbic Acid) Molekül Arl 176,12 g / mol

Eritorbik Asit (Erythorbic Acid) XLogP3 -1.6

Eritorbik Asit (Erythorbic Acid) Hidrojen Ba Donör Says 4

Eritorbik Asit (Erythorbic Acid) Hidrojen Ba Alc Says 6

Eritorbik Asit (Erythorbic Acid) Dönebilen Ba Says 2

Eritorbik Asit (Erythorbic Acid) Tam Kütle 176.032088 g / mol

Eritorbik Asit (Erythorbic Acid) Monoizotopik Kütle 176.032088 g / mol

Eritorbik Asit (Erythorbic Acid) Topolojik Polar Yüzey Alan 107 Å²

Eritorbik Asit (Erythorbic Acid) Ar Atom Says 12

Eritorbik Asit (Erythorbic Acid) Resmi Yük 0

Eritorbik Asit (Erythorbic Acid) Karmakl 232

Eritorbik Asit (Erythorbic Acid) zotop Atom Saym 0

Eritorbik Asit (Erythorbic Acid) Tanml Atom Stereocenter Count 2

Eritorbik Asit (Erythorbic Acid) Tanmsz Atom Stereocenter Says 0

Eritorbik Asit (Erythorbic Acid) Tanml Ba Stereocenter Says 0

Eritorbik Asit (Erythorbic Acid) Tanmsz Ba Stereocenter Says 0

Eritorbik Asit (Erythorbic Acid) Kovalent Bal Birim Says 1

Eritorbik Asit (Erythorbic Acid) Bileii Kanonikalize Edilmitir Evet

Eritorbik asit (izoascorbic asit, d-araboascorbic asit) bir askorbik asit (vitamin C) stereoizomeridir. [1] Metil 2-keto-d-glukonat ve sodyum metoksit arasndaki bir reaksiyonla sentezlenir. Ayrca sükrozdan veya bu özellik için seçilmi Penicillium sular tarafndan sentezlenebilir. [2] E315 ile gösterilir ve ilenmi gdalarda yaygn olarak bir antioksidan olarak kullanlr. Eritorbik asidin besin deerinin özelliklerini aratrmak için klinik deneyler yaplmtr. Böyle bir çalma, genç kadnlarda eritorbik asidin C vitamini metabolizmas üzerindeki etkilerini aratrd; vücuttan C vitamini alm veya klirensi üzerinde hiçbir etkisi bulunmad. [4] Daha sonra yaplan bir aratrma, eritorbik asidin hem-olmayan demir emiliminin güçlü bir arttrcs olduunu buldu. Gda koruyucu olarak eritorbik asit artmtr.Ayrca kürlenmi etlerde ve dondurulmu sebzelerde koruyucu olarak da kullanlmaktadr. 1933 ylnda Alman kimyagerler Kurt Maurer ve Bruno Schiedt tarafndan sentezlenmitir.Erythorbik asit veya daha önce iso askorbik asit olarak bilinen eritorbat ve D-arabo askorbik asit, askorbik asidin bir stereoizomeridir. Eskiden izo askorbik asit ve D-arabo askorbik asit olarak bilinen eritorbik asit veya eritorbat, askorbik asidin bir stereoizomeridir ve kimyasal özelliklerinin Vc ile birçok benzerlii vardr, ancak bir antioksidan olarak, Vc’nin sahip olmad benzersiz bir avantaja sahiptir: Birincisi, anti-oksidasyondan Vc’den üstündür, bu nedenle Vc’yi kartrr, Vc bileeninin özelliklerini etkili bir ekilde koruyabilir. Vc rengini korurken özelliklerini iyiletirmek çok iyi sonuçlar verir. kincisi, daha yüksek güvenlik, insan vücudunda kalnt kalmamas, insan vücudu tarafndan absorbe edildikten sonra metabolizmaya katlma, bu da ksmen Vc’ye dönütürülebilir. Son yllarda Çin tbb, Vc film, Vc Yinqiao-Vc ve salk bakm ürünlerinde kullanlmasn tamamlayc bilgi olarak alyor ve iyi bir etki elde ediyor. Spesifikasyon:% 99 min Dier ad: D-erythro-Hexonicacid, 3-keto-, g-lactone (6CI); Erythorbic acid (7CI); Araboascorbic acid; Araboascorbic acid, D-; D – (-) – Isoascorbic acid; D-Araboascorbic acid; D-Erythorbic acid; D-Isoascorbicacid; D-arabino-Ascorbic acid; Glucosaccharonic acid; Isoascorbic acid; Isovitamin C; Sakarosonik asit. sodyum eritorbat tarafndan asidik durumda üretilir. eritorbik asit güçlü indirgeyici etkiye sahiptir ve kan basncn düürme, diürez, karacier glikojen oluumu, pigment salglama, vücudu detoksifiye etme etkilerine sahiptir. L-askorbik asit epimeri olan eritorbik asit, bir gda katk maddesi olarak Amerika Birleik Devletleri. Diyette eritorbik asit almnn, C vitamini için insan gereksinimi üzerinde herhangi bir yararl veya olumsuz etkisinin olup olmadn belirlemek için çalmalar yaplmtr. Genç kadnlar, kontrollü miktarlarda eritorbik asit ve askorbik asit içeren diyetlerle beslenmitir. Farmakokinetik deerlendirmelerde, eritorbik asit ve askorbik asit, çok az etkileimle hzla emildi. Eritorbik asit vücuttan askorbik asitten daha hzl atlr. Baz denekler <veya = 30 gün boyunca C vitamini eksiklii olan diyetler ald. Artm eritorbik asit alm veya uzun süreli <veya = 1 g eritorbik asit / gün alm askorbik asit ile herhangi bir etkileime iaret etmemitir. Eritorbik asit tüketimi, mononükleer lökositlerde eritorbik asit varlna neden oldu. Bu hücrelerdeki askorbik asit konsantrasyonlar, eritorbik asit varlndan etkilenmedi. Eritorbik asit, eritorbik asit takviyelerinin kesilmesiyle bu hücrelerden hzla kayboldu. Genç kadnlar tarafndan uzun süreli eritrobik asit alm, C vitamini durumlarn ne antagonize etti ne de kurtard.

Eritorbik Asit nasl yaplr?

Metil 2-keto-D-glukonat ve sülfürik asit arasndaki bir reaksiyonla üretilebilir.

Genel olarak üretim sürecinin 5 adm vardr:

Kalsiyum 2-keto-D-glukonat üretimi: kalsiyum karbonatl Pseudomonas fluorescens ile gda snf niasta hidrolizat fermentasyonu.

2-keto-D-glukonik asit (2-KG) elde etmek için yukardaki fermantasyon et suyunu asitletirin.

Metil 2-keto-D-glukonat elde etmek için asit koullar altnda metanol ile esterletirme 2-KG.

Sodyum eritorbat sentezi: yukardaki süspansiyonun sodyum bikarbonat veya sodyum karbonat ile stlmas.

Sodyum eritorbat ile sülfürik asit arasndaki reaksiyon.

Eritorbik asit ile nitrit kombinasyonu kullanldnda nitrosamin üretimini önemli ölçüde azaltabilir.Ayn zamanda etin rengini stabilize edebilir.Mintel GNDP tarafndan Avrupa’da satlan yaklak 1 milyon üründen yaklak 5.000 ürün bildirildi. et ürünlerinde veya et içeren ürünlerde içerik olarak (örnein pizza, yenmeye hazr et yemekleri, et bazl serpme ve doldurulmu makarna) eritorbik asit veya sodyum eritorbat içerir. Eritorbik asit ve sodyum tuzu antioksidan olarak kullanlabilir. içecekler, bira vb. ortadan kaldrabilir.Eritorbik asit (izoascorbic asit, d-araboascorbic asit) bir askorbik asit (vitamin C) stereoizomeridir. [1] Metil 2-keto-d-glukonat ve sodyum metoksit arasndaki bir reaksiyonla sentezlenir. Ayrca sükrozdan veya bu özellik için seçilmi Penicillium sular tarafndan sentezlenebilir. [2] E315 ile gösterilir ve ilenmi gdalarda yaygn olarak bir antioksidan olarak kullanlr. Eritorbik asidin besin deerinin özelliklerini aratrmak için klinik deneyler yaplmtr. Böyle bir çalma, genç kadnlarda eritorbik asidin C vitamini metabolizmas üzerindeki etkilerini aratrd; vücuttan C vitamini alm veya klirensi üzerinde hiçbir etkisi bulunmad. [4] Daha sonra yaplan bir aratrma, eritorbik asidin hem-olmayan demir emiliminin güçlü bir arttrcs olduunu buldu. Gda koruyucu olarak eritorbik asit artmtr.Ayrca kürlenmi etlerde ve dondurulmu sebzelerde koruyucu olarak da kullanlmaktadr. 1933 ylnda Alman kimyagerler Kurt Maurer ve Bruno Schiedt tarafndan sentezlenmitir.Erythorbik asit veya daha önce iso askorbik asit olarak bilinen eritorbat ve D-arabo askorbik asit, askorbik asidin bir stereoizomeridir. Eskiden izo askorbik asit ve D-arabo askorbik asit olarak bilinen eritorbik asit veya eritorbat, askorbik asidin bir stereoizomeridir ve kimyasal özelliklerinin Vc ile birçok benzerlii vardr, ancak bir antioksidan olarak, Vc’nin sahip olmad benzersiz bir avantaja sahiptir: Birincisi, anti-oksidasyondan Vc’den üstündür, bu nedenle Vc’yi kartrr, Vc bileeninin özelliklerini etkili bir ekilde koruyabilir. Vc rengini korurken özelliklerini iyiletirmek çok iyi sonuçlar verir. kincisi, daha yüksek güvenlik, insan vücudunda kalnt kalmamas, insan vücudu tarafndan absorbe edildikten sonra metabolizmaya katlma, bu da ksmen Vc’ye dönütürülebilir. Son yllarda Çin tbb, Vc film, Vc Yinqiao-Vc ve salk bakm ürünlerinde kullanlmasn tamamlayc bilgi olarak alyor ve iyi bir etki elde ediyor. Spesifikasyon:% 99 min Dier ad: D-erythro-Hexonicacid, 3-keto-, g-lactone (6CI); Erythorbic acid (7CI); Araboascorbic acid; Araboascorbic acid, D-; D – (-) – Isoascorbic acid; D-Araboascorbic acid; D-Erythorbic acid; D-Isoascorbicacid; D-arabino-Ascorbic acid; Glucosaccharonic acid; Isoascorbic acid; Isovitamin C; Sakarosonik asit. sodyum eritorbat tarafndan asidik durumda üretilir. eritorbik asit güçlü indirgeyici etkiye sahiptir ve kan basncn düürme, diürez, karacier glikojen oluumu, pigment salglama, vücudu detoksifiye etme etkilerine sahiptir. L-askorbik asit epimeri olan eritorbik asit, bir gda katk maddesi olarak Amerika Birleik Devletleri. Diyette eritorbik asit almnn, C vitamini için insan gereksinimi üzerinde herhangi bir yararl veya olumsuz etkisinin olup olmadn belirlemek için çalmalar yaplmtr. Genç kadnlar, kontrollü miktarlarda eritorbik asit ve askorbik asit içeren diyetlerle beslenmitir. Farmakokinetik deerlendirmelerde, eritorbik asit ve askorbik asit, çok az etkileimle hzla emildi. Eritorbik asit vücuttan askorbik asitten daha hzl atlr. Baz denekler <veya = 30 gün boyunca C vitamini eksiklii olan diyetler ald. Artm eritorbik asit alm veya uzun süreli <veya = 1 g eritorbik asit / gün alm askorbik asit ile herhangi bir etkileime iaret etmemitir. Eritorbik asit tüketimi, mononükleer lökositlerde eritorbik asit varlna neden oldu. Bu hücrelerdeki askorbik asit konsantrasyonlar, eritorbik asit varlndan etkilenmedi. Eritorbik asit, eritorbik asit takviyelerinin kesilmesiyle bu hücrelerden hzla kayboldu. Genç kadnlar tarafndan uzun süreli eritrobik asit alm, C vitamini durumlarn ne antagonize etti ne de kurtard.

Eritorbik Asit nasl yaplr?

Metil 2-keto-D-glukonat ve sülfürik asit arasndaki bir reaksiyonla üretilebilir.

Genel olarak üretim sürecinin 5 adm vardr:

Kalsiyum 2-keto-D-glukonat üretimi: kalsiyum karbonatl Pseudomonas fluorescens ile gda snf niasta hidrolizat fermentasyonu.

2-keto-D-glukonik asit (2-KG) elde etmek için yukardaki fermantasyon et suyunu asitletirin.

Metil 2-keto-D-glukonat elde etmek için asit koullar altnda metanol ile esterletirme 2-KG.

Sodyum eritorbat sentezi: yukardaki süspansiyonun sodyum bikarbonat veya sodyum karbonat ile stlmas.

Sodyum eritorbat ile sülfürik asit arasndaki reaksiyon.

Eritorbik asit, askorbik asidin (Vitamin C) bir stereoizomeridir. Askorbik aside, NOP yönetmeliklerinde §205.605’te ilenmi organik ürünlerin içinde veya üzerinde sentetik bir bileen olarak izin verilirken, stereoizomerler konusu kuralda ele alnmamaktadr. Bir stereoizomer, dieriyle ayn formül ve bal atom dizisine sahip, ancak üç boyutlu yöneliminde farkllk gösteren bir moleküldür. Örnein, elleriniz molekül, avucunuz ve rakam atomlar olsayd, sol eliniz sanzn bir stereoizomeri olurdu. Hem askorbik asit hem de eritorbik asit, çok çeitli gdalarda antioksidan koruyucular olarak yaygn olarak kullanlmaktadr. ABD FDA’nn bu amaçla sülfit kullanmn yasaklamasndan bu yana, ham olarak yenmesi amaçlanan gdalarda koruyucu olarak eritorbik asidin kullanm artmtr. Asit, asl soru eritorbik asidin askorbik asit ile kimyasal olarak ayn olup olmaddr. Malzemelerin farkl CAS kayt numaralar vardr ve bu, farkl kimyasallar olduklarnn bir göstergesidir. American Chemical Society’ye göre biri dierinin kimliine girmiyor. Çalmalar doal ve sentetik askorbik asidin biyolojik sistemlerde benzer ekilde davrandn gösterirken, askorbik asit stereoizomerleri karlatrldnda azalm bir anti-askorbutik aktivite gösteriyor. Bu, materyallerin metabolik sistemlerde fonksiyonel olarak en azndan derece olarak farkl olduunun açk bir göstergesidir.OMRI sonuç olarak iki materyali kimyasal ve fonksiyonel olarak farkl kabul eder ve eritorbik asidin organik ileme için askorbik asit ödeneine dahil edilmesini dikkate almaz . çerii organik ilemede kullanmak isteyenler, eritorbik asidin özel olarak ele alnmas için D’den ricada bulunmaya tevik edilecektir.

Geçmi: Benzer fizikokimyasal özelliklere sahip bir askorbik asit stereoizomeri olan eritorbik asit, ilenmi gdalarda bir antioksidan olarak yaygn ekilde kullanlmaktadr.

Amaçlar: Bu çalmann amac, 2: 1 ve 4: 1 (demire göre) molar oranlarda demir sülfattan demir emilimi üzerine eritorbik asidin etkisini deerlendirmek ve eritorbik asidin etkisini direkt olarak karlatrmaktr. 4: 1 molar orannda askorbik asit.

Tasarm: Demir ile kuvvetlendirilmi tahldan demir emilimi, uygulamadan 14 gün sonra stabil demir izotoplarnn (57Fe veya 58Fe) eritrosit eklenmesi temelinde 10 kadnda ölçüldü. Her kadn eritorbik veya askorbik asit eklenmi veya eklenmemi 4 demir sülfatla güçlendirilmi test yemei (5 mg Fe / öün içerir) tüketmitir. Veriler, eletirilmi t testleri kullanlarak deerlendirildi ve sonuçlar geometrik ortalamalar olarak sunuldu.

Sonuçlar: Herhangi bir güçlendirici eklenmeden test yemeinden demir emilimi% 4.1 idi. Eritorbik asit ilavesi (demire göre 2: 1 ve 4: 1 molar oranlarda) demir emilimini srasyla 2.6 kat (% 10.8; P <0.0001) ve 4.6 kat (% 18.8; P <0.0001) artrmtr. Askorbik asit ilavesi (4: 1 molar oran) demir emilimini 2.9 kat arttrd (% 11.7; P = 0.0004). 4: 1’lik bir molar oranda, askorbik asit kadar güçlü bir demir absorpsiyonu arttrcs olarak eritorbik asit 1.6 kat (P = 0.0002) idi.

Sonuç: Eritorbik asit, demir emiliminin güçlü bir arttrcs olmasna ramen, antiskorbütik aktivitesinin olmamas, demir takviyesi programlarndaki yararlln snrlar. Bununla birlikte, eritorbik asit ile korunmu gdalar içeren karma diyetlerden demir biyoyararlanmn artrmada önemli bir rol oynayabilir.

Fonksiyonlar ve Uygulamalar

1. Eritorbik asit, asidik durumda sodyum eritorbat tarafndan üretilir.

2. Eritorbik asit, güçlü indirgeme etkisine sahiptir ve kan basncn, diürezi, karacier glikojenini, pigmenti salglamay, vücudu detoksifiye etmeyi azaltmada etkileri vardr.

3. Toksik deildir, dier uygulamalar sodyum eritorbat ile ilgilidir. Sodyum eritorbat ve eritorbik asit genellikle en son A snf olarak kabul edilir

Uluslararas düzeyde yeil ürünler ve hem yurtiçi hem de yurtdnda kt arzda mal haline geldi

Eritorbik asit

Amerika Birleik Devletleri Farmakopesi (USP) Referans Standard

Eanlaml: D – (-) – zokorbik asit, D-eritro-Heks-2-enoik asit-lakton, D-Araboascorbic asit, Eritorbik asit, Glukosakaronik asit, NSC 8117 CAS Numaras 89-65-6

Ampirik Formül (Hill Notasyonu) C6H8O6 Moleküler Arlk 176.12 Beilstein Kayt Numaras 84271 MDL numaras MFCD00005378 Madde Kimlii 329749380

Eritorbik asit Amerika Birleik Devletleri Farmakopesi (USP) Referans Standard SDS Benzer Ürünler Stok Kodu Boyutu Kullanlabilirlik Fiyat (EUR) 1241823-50MG

14.08.19 407.00 Ürün sipari etmek için lütfen yerel bayinizle iletiime geçin. Buraya tklayn Ürün Önerileri W241008 D-zokorbik asit FCC, FG 856061 D – (-) –

zokorbik asit% 98 496332 Sodyum D-izokorbat monohidrat% 97 üst Satn Alma Güvenlii ve Dokümantasyon Özellikler lgili Kategoriler Analitik Standartlar,

Eritorbat, zoaskorbik asit. Tanmlayclar CAS Numaras 89-65-6? 3B model (JSmol) Etkileimli resim ChEBI CHEBI: 51438? ChemSpider 16736142? ECHA Bilgi Kart 100.001.753

E numaras E315 (antioksidanlar, …) CID 6981 UNII 311332OII1? CompTox Dashboard (EPA) DTXSID6026537 Bunu Vikiveri InChI’da düzenleyin

dorulayn (nedir ???) Infobox referanslar Eritorbik asit (izoascorbic asit, D-araboascorbic asit) askorbik asidin (vitamin C) bir stereoizomeridir. [1] Metil 2-keto-D-glukonat ile sodyum metoksit arasndaki reaksiyonla sentezlenir. Ayrca sükrozdan veya bu özellik için seçilmi Penicillium sular tarafndan sentezlenebilir. [2] E numaras E315 ile gösterilir ve ilenmi gdalarda yaygn olarak antioksidan olarak kullanlr. [3]

/ DER TOKSSTE BLGLER / Son deerlendirmede, sçanda uzun süreli bir çalmaya dayal olarak 0-5 mg / kg canl arlk / Kabul Edilebilir Günlük Alm / (ADI) tahsis edildi. Mevcut / Ortak FAO / WHO Gda Katk Maddeleri Uzman Komitesi /, izokorbik asit ve sodyum tuzu ile ilgili yeni toksikolojik çalmalar ve askorbik asit ile etkileimlerin metabolik ve beslenme çalmalarn gözden geçirdi.

ndirgenmi eritorbik asit formu, 2 saatte% 20 orannda insan eritrositlerine dahil edildi ve bu formun alm hz hücre d konsantrasyon ile orantlyd. Oksitlenmi eritorbik asit formu, D-dehidroizokorbik asit, 5 dakikada% 50 orannda indirgenmi formdan daha hzl bir ekilde dahil edildi ve emilen asidin% 80’i daha sonra hücreler içinde azald. ndirgenmi eritorbik asit formu, plazmada oksitlenmi formdan daha stabildi, bunun% 61’i 60 dakikada bozuldu. Eritrositlerde, indirgenmi form, plazmada olduu gibi stabildi ve oksitlenmi form biraz daha azdr. Biyolojik Yar Ömür:

Köpeklerde bu, plazmadaki eritorbik asit için yaklak 30 dakikalk bir yar ömre neden oldu.

[Kozmetik çerik Uzman nceleme Paneli; Askorbil Palmitat, Askorbil Dipalmitat, Askorbil Stearat, Eritorbik Asit ve Sodyum Eritorbatn Güvenlik Deerlendirmesine likin Nihai Rapor; International Journal of Toxicology 18 (Suppl 3): 1-26 (1999).] ** HAKEM NCELEMES **

Etkileimler:

N-metil-N’-nitro-N-nitrosoguanidin ile balatlan F344 sçanlarnda 3 antioksidan, sodyum L-askorbat (SA), askorbik asit (AA) ve sodyum eritorbatn (SE) iki aamal gastrik karsinojenez üzerindeki deitirici etkileri ( MNNG) incelendi. Diyette% 5 SE verilmesi, pilor displazisi insidansn ve daha marjinal olarak ön midede papilloma insidansn önemli ölçüde düürürken, diyette% 5 ve% 1 SA ve% 5 AA uygulanmas etki ile ilikili deildi. . Bu sonuçlar, SE’nin mide karsinojenezinde zayf bir inhibitör etki gösterdiini göstermektedir. / Sodyum eritorbat / Sçanlarda ve köpeklerde tetrasiklin-HCl’nin (50 mg / kg) hzl iv uygulamasyla indüklenen belirgin azotemi ve böbrek hasarnn dier kantlar, askorbik asitin (125 mg / kg veya daha fazla) birlikte uygulanmasyla önlendi. D-izokorbik asit, sçanlarda test edildiinde benzer bir etkiye sahipti.

Farmakoloji:

Terapötik Kullanmlar: Eritorbik asit, bir askorbik asit stereoizomeridir ve gdalarda ve oral farmasötik formülasyonlarda bir antioksidan olarak kullanlr. Askorbik asidin C vitamini aktivitesinin yaklak% 5’ine sahiptir.

Etkileimler: 3 antioksidan, sodyum L-askorbat (SA), askorbik asit (AA) ve sodyum eritorbatn (SE), N-metil-N’-nitro-N- ile balatlan F344 sçanlarnda iki aamal mide karsinojenezindeki modifiye edici etkileri nitrosoguanidin (MNNG) aratrld. Diyette% 5 SE verilmesi, pilor displazisi insidansn ve daha marjinal olarak ön midede papilloma insidansn önemli ölçüde düürürken, diyette% 5 ve% 1 SA ve% 5 AA uygulanmas etki ile ilikili deildi. . Bu sonuçlar, SE’nin mide karsinojenezinde zayf bir inhibitör etki gösterdiini göstermektedir. / Sodyum eritorbat / Sçanlarda ve köpeklerde tetrasiklin-HCl’nin (50 mg / kg) hzl iv uygulamasyla indüklenen belirgin azotemi ve böbrek hasarnn dier kantlar, askorbik asitin (125 mg / kg veya daha fazla) birlikte uygulanmasyla önlendi. D-izokorbik asit, sçanlarda test edildiinde benzer bir etkiye sahipti. Scorbutic (düük kollajen) granülomlar, s.c. C vitamini eksiklii olan erkek kobaylara karragenan enjeksiyonu zokorbik asit ve askorbik asit (12 saat aralklarla 6 doz 100 mg ip) granülomda kolajen sentezinin geri kazanlmasnda benzer ekilde etkiliydi, ancak enjeksiyondan 12 saat sonra eritorbik asit konsantrasyonu Enjeksiyondan 24 saat sonra askorbik asitten daha düük (Robertson, 1963). (b) in vitro çalmalar

Askorbik asit ve eritorbik asit, hücresiz bir sistemde peptidil prolinin hidroksilasyonunu tevik etmede benzer aktivite gösterdi (Hutton ve dierleri, 1967; Kutnink ve dierleri, 1969) ve bu gözlemler, saflatrlm bir prolil 4-dihidroksilaz preparat kullanlarak dorulanmtr. Eritorbik asit, hepatik mikrozomal UDP-glukuroniltransferaz aktivitesini p-ami’ye kar korumada askorbik aside benzer bir etkiye sahipti.Fazla substrata kar nofenol, ancak askorbat-2-sülfat veya alfa-tokoferol tarafndan hiçbir koruma salanmad. Askorbat ve eritorbatn kolajen sentezi üzerindeki etkileri, kültürlenmi insan derisi fibroblastlarnda çalld. Kültür ortamndaki 0.25 mM’lik konsantrasyonlarda, hem askorbat hem de eritorbat, kolajen sentezini, kolajen olmayan proteinin sentezinde önemli bir deiiklik olmakszn yaklak sekiz kat arttrd. Lisil hidroksilaz aktivitesi askorbat veya eritorbat uygulamasna yant olarak 3 kat artt. Hücrelerin askorbat veya eritorbata uzun süre maruz kalmasndan sonra, prolil hidroksilaz aktivitesi benzer ölçüde azald. Sonuçlar, iki hidroksilazn kolajen polipeptit sentezinin, posttranslasyonel hidroksilasyonlarnn ve aktivitelerinin bamsz olarak askorbat tarafndan düzenlendiini ve eritorbat kullanlan yüksek konsantrasyonlarda benzer etkilere sahip olduunu göstermek için alnmtr (Murad ve dierleri, 1981). nsan derisi fibroblastlarnn kullanld daha ileri çalmalarda askorbat, hücre içi serbest prolinin spesifik aktivitesini deitirmeden, etiketlenmi prolinin toplam kolajenaza duyarl proteine katlma orann uyard. Askorbatn etkisi, 30 uM’lik bir konsantrasyonda maksimumdu ve dahil edilmede dört kat artla sonuçland. Erythorbat ayrca, 250-300 uM’lik önemli ölçüde daha yüksek konsantrasyonlarda kolajen sentezini de uyarmtr. Kolajen sentezinin askorbat ve eritorbat tarafndan uyarlmasna, prolil hidroksilaz aktivitesinde bir düü ve lizil hidroksilaz aktivitesinde bir art elik etti; yine askorbat daha etkiliydi (Murad ve dierleri, 1983). Askorbik ve eritorbik asidin karbon tetraklorür kaynakl lipid peroksidasyonuna kar koruyucu etkileri, in vivo lipid peroksidasyonunun bir indeksi olarak pentan ve etann ekshalasyonu kullanlarak kobaylarda aratrld. Askorbik asit veya izokorbik asidin eit dozlarnn (750 mg / kg vücut arl, i.p.) en az 4 saatlik bir süre boyunca ayn koruma derecesini salad görülmütür (Kunert & Tappel, 1983). Yazarlar, askorbik asidin antioksidan fonksiyonunun nispeten spesifik olmad ve iki stereoizomerin in vivo antioksidan özelliklerine göre farkllk göstermedii sonucuna varmlardr.

2.3 nsanlarda gözlemler

Eritorbik asidin dokudan askorbik asidi deitirip deitiremeyeceini belirlemek için, daha önce 7 gün boyunca 500 mg askorbik asit uygulanarak tekrarlanan 5 salkl insan gönüllü tarafndan 300 mg eritorbik asit almndan sonra üriner askorbik asit seviyeleri ölçüldü. drar analizleri askorbik asit atlmnn eritorbik asit tedavisinden etkilenmediini ve askorbik asidin dokulardan önemli ölçüde yer deitirmediini gösterdi (Kadin ve Osadca, 1959). Eritorbik asidin askorbik asit metabolizmas ve durumu üzerindeki etkisi 11’de aratrld. salkl, hamile olmayan kadn gönüllüler. Gönüllüler bir metabolik ünitede tutuldu ve 54 gün boyunca C vitamini içermeyen bir formül diyetiyle beslendi. 24 günlük tükenmeden sonra denekler, 600 mg / gün eritorbik asit varlnda veya yokluunda artan askorbik asit takviyeleri (10 günlük ardk süreler için 30 mg / gün, 60 mg / gün ve 90 mg / gün) ald. Tükenme tüm kan indekslerinde askorbik asitte belirgin bir düüe neden oldu ve çalma srasnda baz denekler iskorbüt belirtileri gelitirdi. 10 gün süreyle günde 30 mg askorbik asit takviyeleri, plazma askorbat konsantrasyonlarn artrmada baarsz oldu; 10 gün süreyle 60 mg, küçük bir arta neden oldu ve 90 mg / gün, 29 mmol / l’lik bir ortalama askorbik asit konsantrasyonu ile sonuçland. Eritorbik asit herhangi bir yan etkiye neden olmad, bunun yerine küçük bir askorbik asit koruyucu etkiye sahipti.

3. YORUMLAR

Son deerlendirmede 0-5 mg / kg canl arlk ADI’si. farede uzun süreli bir çalmaya göre tahsis edilmitir. Bu Komite, izokorbik asit ve sodyum tuzu üzerine yeni toksikolojik çalmalar ve askorbik asit ile etkileimlerin metabolik ve beslenme çalmalarn gözden geçirdi.

Eritorbik Asit (Eritorbik Asit)

Ayn zamanda izaskopik asit olarak da bilinen eritoribik asit, sakarozdan üretilen doal bir ürün, bitkisel kaynakl gda katk maddesidir. Eritoribik asit, gda endüstrisinde gdalarn rengini, doal lezzetini koruyabilen ve toksik ve yan etkileri olmadan gda depolamay uzatan önemli bir antioksidandr. Eritoribik asit, ilenmi et ilemede, dondurulmu meyvelerde, dondurulmu sebzelerde, reçellerde ve bira, üzüm arab, merubat, meyve suyu ve meyve çaylar gibi içecek endüstrisinde kullanlr. ABD Gda ve laç daresi, taze yenecek gdalarda (yani: salata bar malzemeleri) koruyucu olarak sülfit kullanmn yasakladndan beri eritoribik asit kullanm muazzam bir ekilde artmtr.

Ambalaj: 25 kg Karton

Eritorbik Asit (Eritorbik Asit) (izoascorbic asit, D-araboascorbic acid), askorbik asidin (vitamin C) bir stereoizomeridir. Metil 2-keto-D-glukonat ile sodyum metoksit arasndaki reaksiyonla sentezlenir. Ayrca sakarozdan veya özel olarak seçilmi Penicillium sular tarafndan sentezlenebilir.r bu özellik. E numaras E315 ile gösterilir ve ilenmi gdalarda yaygn olarak bir antioksidan olarak kullanlr.Eritorbik Asit (Eritorbik Asit) besin deerinin özelliklerini aratrmak için klinik denemeler yaplmtr. Böyle bir çalma, genç kadnlarda Eritorbik Asit’in (Eritorbik Asit) C vitamini metabolizmas üzerindeki etkilerini aratrd; vücuttan C vitamini alm veya klirensi üzerinde hiçbir etkisi bulunmad. Daha sonra yaplan bir çalmada, Eritorbik Asit’in (Eritorbik Asit) güçlü bir hem-olmayan demir emilimi arttrcs olduu bulundu. Eritorbik Asit’in (Eritorbik Asit) gda koruyucu olarak kullanm artmtr. Ayn zamanda ilenmi etlerde ve dondurulmu sebzelerde koruyucu olarak da kullanlr. lk olarak 1933 ylnda Alman kimyagerler Kurt Maurer ve Bruno Schiedt tarafndan sentezlendi.

Eritorbik Asit (Eritorbik Asit)

Eskiden izokorbik asit ve D-araboascorbic asit olarak bilinen Eritorbik Asit (Eritorbik Asit), askorbik asidin bir stereoizomeridir. Sakarozdan üretilen bitkisel kaynakl bir gda katk maddesidir. E numaras E315 ile gösterilir ve ilenmi gdalarda yaygn olarak bir antioksidan olarak kullanlr. Eritorbik Asit (Eritorbik Asit) besin deerinin özelliklerini aratrmak için klinik aratrmalar yaplmtr. Böyle bir çalma, genç kadnlarda Eritorbik Asit’in (Eritorbik Asit) C vitamini metabolizmas üzerindeki etkilerini aratrd; vücuttan C vitamini alm veya klirensi üzerinde hiçbir etkisi bulunmad. Daha sonraki bir çalmada, Eritorbik Asit’in (Eritorbik Asit) güçlü bir hem-içermeyen demir emilimi arttrcs olduu bulundu. ABD Gda ve laç daresi, taze yenmesi amaçlanan gdalarda koruyucu olarak sülfit kullanmn yasakladndan, gda koruyucu olarak Eritorbik Asit (Eritorbik Asit) kullanm artmtr. Ayn zamanda, ilenmi etlerde ve dondurulmu sebzelerde koruyucu olarak kullanlr.

Eritorbik Asit (Eritorbik Asit), çou ülkedeki popüler gda katk maddelerinden ve bileenlerinden biridir.Profesyonel bir Eritorbik Asit (Eritorbik Asit) tedarikçisi ve üreticisi olarak, Foodchem International Corporation, Çin’den Eritorbik Asit (Eritorbik Asit) tedarik etmekte ve ihraç etmektedir. 10 yl, lütfen Foodchem’den Eritorbik Asit (Eritorbik Asit) satn aldnzdan emin olun. Herhangi bir sorunuz ve sorununuz varsa lütfen sales@foodchem.cn araclyla bize e-posta göndermekten çekinmeyin, size 1 i günü içinde cevap vereceiz.

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