GLYOXYLIC ACID (GLOKSLK AST)
GLYOXYLIC ACID (GLOKSLK AST)
CAS Number:298-12-4
EC Number:206-058-5
SYNONMYS
Glyoxylic acid monohydrate 98%; Formylformic acid, Oxoethanoic acid; MDL number MFCD00149497; Molecular Weight 92.05; Linear Formula HCOCO2H · H2O; Substance ID 24895036; glyoxalic acid; glyoxylate; glyoxylic acid; glyoxylic acid, 14C2-labeled; glyoxylic acid, 2-(14)C-labeled; glyoxylic acid, calcium salt; glyoxylic acid, sodium salt; glyoxylic acid, sodium salt, 14C-labeled; glyoxylic acid, sodium salt, 2-(14)C-labeled; glyoxylic acid; 298-12-4; 2-Oxoacetic Acid; Glyoxalic acid; Oxoacetic acid; Oxoethanoic acid; Formylformic acid; Acetic acid, oxo-; Oxalaldehydic acid; alpha-Ketoacetic acid; 2-Oxoacetic acid(50% in water); Formic acid, formyl-; glyoxalate; oxaldehydic acid; Kyselina glyoxylova; GLYOXALATE, GLYOXYLATE; Acetic acid, 2-oxo-; CCRIS 1455; HSDB 5559; Oxo-acetic acid; 563-96-2; Kyselina glyoxylova [Czech]; UNII-JQ39C92HH6; NSC 27785; OCHCOOH; .alpha.-Ketoacetic acid; EINECS 206-058-5; BRN0741891; CHEBI:16891; HHLFWLYXYJOTON-UHFFFAOYSA-N; glyox; oxoacetate; NSC27785; MFCD00006958; glyoxalic acid hydrate; GLV; formylformic; Formylformate; Glyoxalsaeure; Glyoxylsaeure; Oxalaldehydate; Oxoethanoate; glyoxilic acid; a-Ketoacetate; formyl-formicaci; aldehydoformicacid; alpha-Ketoacetate; 2-Oxoacetate ; (oxo)acetic acid; a-Ketoacetic acid; Acetic acid, oxo; alpha-ketoaceticacid; Formic acid, formyl; OHCCO2H; Glyoxylic acid (8CI); WLN: VHVQ; glyoxylicacid(50%orless); D0U9EW; AC1L19YQ; AC1Q71YA; AC1Q71YB; Acetic acid, oxo- (9CI); glyoxylicacid(oxo-aceticacid); 4-03-00-01489 (Beilstein Handbook Reference); KSC201S7T; GLYOXYLIC ACID CRYS..; Glyoxylic acid, 50% in water; JQ39C92HH6; CHEMBL1162545; DTXSID5021594; BDBM19472; CTK1A1979; Glyoxylic acid (50% in water); KS-00000QWZ; 2990-19-4 (calcium salt); MolPort-001-788-315; EBD11505; KS-00000KI7; ZINC4658554; 2706-75-4 (hydrochloride salt); ANW-26704; Glyoxylic acid, 50% w/w aq. soln; NSC-27785; STL168883; AKOS005367012; DB04343; MCULE-5307898766; RL03029; RTR-012899; AJ-51836; AK-48128; AK109361; AN-23352
BC679582; BR-48128; LS-73000; OR034470; OR254685; SC-18712; SC-25819; Glyoxylic Acid Solution, 50wt.% in H2O; KB-254206; ST2410189; TR-012899; FT-0626797; G0366; Glyoxylic acid solution, 50 wt. % in H2O; ST24040983; W5228; C00048; Glyoxylic acid solution, purum, ~50% in H2O; 78606-EP2295432A1; 78606-EP2308847A1Glyoxylic acid solution, 50 wt. % in water 250g; I04-0231; W-105518; I14-19186; F2191-0150; 0ADD8E81-5E77-4171-9241-E74AC05D4C8D; 872051-56-4; 298-12-4 [RN]Acetic acid, 2-oxo- [ACD/Index Name]; Acide glyoxyl [French] [ACD/IUPAC Name]; Acide glyoxylique [French]; a-Ketoacetic acid; Glyoxyl acid [ACD/IUPAC Name]Glyoxylic acid [Wiki]; Glyoxylsäure [German]; Oxoacetic acid; Oxoessigsäure [German] [ACD/IUPAC Name]; 206-058-5 [EINECS]; 2-Oxo acid; 2-Oxoacetic Acid; 2-Oxoacetic acid(in water); 4-03-00-01489 (Beilstein Handbook Reference) [Beilstein]; 741891 [Beilstein]; Acetic acid, oxo-; Acetic acid, oxo- (9CI); BR-48128Formic acid, formyl; Formic acid, formyl-; formylformic acid; Formylformic acid monohydrate; GLV; Glycoxylic acid; glyox; Glyoxalic acid; glyoxalic acid hydrate; Glyoxalsaeure; Glyoxylic acid (8CI); Glyoxylsaeure; JQ39C92HH6; Kyselina glyoxylova [Czech]; oxalaldehydic acid; oxaldehydic acid; oxaldehydic acid hydrate; Oxalic acid [ACD/IUPAC Name] [Wiki]; OXD; Oxo-acetic acid; OXOETHANOIC ACID; Oxoethanoic acid monohydrate; UNII:JQ39C92HH6; UNII-JQ39C92HH6; WLN: VHVQ; ?-ketoacetic acid; ?-ketoacetic acid; ?-Ketoacetic acid; ??? [Chinese]; Acetic acid, 2-oxo-, hydrate (1:1) [ACD/Index Name]; Acide oxoacétique, hydrate (1:1) [French] [ACD/IUPAC Name]; Glyoxylic acid monohydrate [Wiki]; Oxoacetic acid hydrate (1:1) [ACD/IUPAC Name]; Oxoessigsäurehydrat (1:1) [German] [ACD/IUPAC Name]; [563-96-2]; 1152495-30-1 [RN]; 206-058-5 [EINECS]; 298-12-4 [RN]; 2-Methylpropanamide [ACD/IUPAC Name]; 2-Oxoacetic Acid; 2-Oxoacetic acid hydrate; 2-Oxoacetic acid monohydrate; 2-Oxoethanoic acid monohydrate; 563-96-2 [RN]; 6000-59-5 [RN]; formylformic acid; Formylformic acid monohydrate; Glyoxalic acid; glyoxalic acid hydrate; Glyoxalic acid hydrate;Glyoxylic acid monohydrate; Glyoxalic Acid Monohydrate; Glyoxylic Acid Hydrate; Glyoxylic acid monohydrate, Formylformic acid monohydrate, 2-Oxoethanoic acid monohydrate; Glyoxylic acid monohydrate; Formylformic acid monohydrate; 2-Oxoethanoic acid monohydrate; Glyoxylic acid monohydrate; Formylformic acid monohydrate; 2-Oxoethanoic acid monohydrate; 563-96-2 (diol); glyoxylicacidhydrate; Glyoxylicacidmonohydrate; oxaldehydic acid and hydrate; oxoacetate monohydrate; oxoacetic acid hydrate; Oxoacetic acid monohydrate; Oxoacetic acid–water (1/1); OXOETHANOIC ACID; QA-1237; glyoxylic; InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5); GA;OCHCOOH;Glyoxalate;glyoxylate;Glyoxylsure;Formylformic;oxo-aceticaci;GLYOXALIC ACID;GLYOXYLIC ACID;oxo-acetic acid; CHEBI:42767, CHEBI:5509, CHEBI:24421; InChI?=?1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5); InChIKey?=?HHLFWLYXYJOTON-UHFFFAOYSA-N; Glyoxylic acid monohydrate for synthesis. ; Oxoethanoic acid, Oxoacetic acid, Acetic acid, Oxo-, Glyoxalic acid; Glyoxylic acid; glyoxylic acid; oxaldehydic acid; glyoxalate; glyoxylic acid; oxoacetic acid glyoxalic acid; Exchange reactions, glyoxal oxidation, glyoxylic acid, selective separation, sodium glyoxylate; Glyoxylic acid … ; Glyoxylic Acid Monohydrate 98%; oxoacetic acid; Glyoxylic oxime acid, bis(trimethylsilyl)-; InChI=1S/C8H19NO3Si2/c1-13(2,3)11-8(10)7-9-12-14(4,5)6/h7H,1-6H3; Glyoxylic acid, oxime, bis-TMS; Glyoxylic acid, oxime, di-TMS; Glyoxylic oxime, bis-TMS; Glyoxylic oxime, (2TMS); Glyoxylic oxime, TMS; Glycolic acid, oxime, TMS; Oximated glyoxylic acid, diTMS; Glyoxylic Acid ;Glyoxylic acid monohydrate 98%; Formylformic acid, Oxoethanoic acid; MDL number MFCD00149497; Molecular Weight 92.05; Linear Formula HCOCO2H · H2O; Substance ID 24895036; glyoxalic acid; glyoxylate; glyoxylic acid; glyoxylic acid, 14C2-labeled; glyoxylic acid, 2-(14)C-labeled; glyoxylic acid, calcium salt; glyoxylic acid, sodium salt; glyoxylic acid, sodium salt, 14C-labeled; glyoxylic acid, sodium salt, 2-(14)C-labeled; glyoxylic acid; 298-12-4; 2-Oxoacetic Acid; Glyoxalic acid; Oxoacetic acid; Oxoethanoic acid; Formylformic acid; Acetic acid, oxo-; Oxalaldehydic acid; alpha-Ketoacetic acid; 2-Oxoacetic acid(50% in water); Formic acid, formyl-; glyoxalate; oxaldehydic acid; Kyselina glyoxylova; GLYOXALATE, GLYOXYLATE; Acetic acid, 2-oxo-; CCRIS 1455; HSDB 5559; Oxo-acetic acid; 563-96-2; Kyselina glyoxylova [Czech]; UNII-JQ39C92HH6; NSC 27785; OCHCOOH; .alpha.-Ketoacetic acid; EINECS 206-058-5; BRN0741891; CHEBI:16891; HHLFWLYXYJOTON-UHFFFAOYSA-N; glyox; oxoacetate; NSC27785; MFCD00006958; glyoxalic acid hydrate; GLV; formylformic; Formylformate; Glyoxalsaeure; Glyoxylsaeure; Oxalaldehydate; Oxoethanoate; glyoxilic acid; a-Ketoacetate; formyl-formicaci; aldehydoformicacid; alpha-Ketoacetate; 2-Oxoacetate ; (oxo)acetic acid; a-Ketoacetic acid; Acetic acid, oxo; alpha-ketoaceticacid; Formic acid, formyl; OHCCO2H; Glyoxylic acid (8CI); WLN: VHVQ; glyoxylicacid(50%orless); D0U9EW; AC1L19YQ; AC1Q71YA; AC1Q71YB; Acetic acid, oxo- (9CI); glyoxylicacid(oxo-aceticacid); 4-03-00-01489 (Beilstein Handbook Reference); KSC201S7T; GLYOXYLIC ACID CRYS..; Glyoxylic acid, 50% in water; JQ39C92HH6; CHEMBL1162545; DTXSID5021594; BDBM19472; CTK1A1979; Glyoxylic acid (50% in water); KS-00000QWZ; 2990-19-4 (calcium salt); MolPort-001-788-315; EBD11505; KS-00000KI7; ZINC4658554; 2706-75-4 (hydrochloride salt); ANW-26704; Glyoxylic acid, 50% w/w aq. soln; NSC-27785; STL168883; AKOS005367012; DB04343; MCULE-5307898766; RL03029; RTR-012899; AJ-51836; AK-48128; AK109361; AN-23352BC679582; BR-48128; LS-73000; OR034470; OR254685; SC-18712; SC-25819; Glyoxylic Acid Solution, 50wt.% in H2O; KB-254206; ST2410189; TR-012899; FT-0626797; G0366; Glyoxylic acid solution, 50 wt. % in H2O; ST24040983; W5228; C00048; Glyoxylic acid solution, purum, ~50% in H2O; 78606-EP2295432A1; 78606-EP2308847A1Glyoxylic acid solution, 50 wt. % in water 250g; I04-0231; W-105518; I14-19186; F2191-0150; 0ADD8E81-5E77-4171-9241-E74AC05D4C8D; 872051-56-4; 298-12-[RN Acetic acid, 2-oxo- [ACD/Index Name]; Acide glyoxyl [French] [ACD/IUPAC Name]; Acide glyoxylique [French]; a-Ketoacetic acid; Glyoxyl acid [ACD/IUPAC Name]Glyoxylic acid [Wiki]; Glyoxylsäure [German]; Oxoacetic acid; Oxoessigsäure [German] [ACD/IUPAC Name]; 206-058-5 [EINECS]; 2-Oxo acid; 2-Oxoacetic Acid; 2-Oxoacetic acid(in water); 4-03-00-01489 (Beilstein Handbook Reference) [Beilstein]; 741891 [Beilstein]; Acetic acid, oxo-; Acetic acid, oxo- (9CI); BR-48128Formic acid, formyl; Formic acid, formyl-; formylformic acid; Formylformic acid monohydrate; GLV; Glycoxylic acid; glyox; Glyoxalic acid; glyoxalicacidhydrate; Glyoxalsaeure; Glyoxylic acid (8CI); Glyoxylsaeure; JQ39C92HH6; Kyselina glyoxylova [Czech]; oxalaldehydic acid; oxaldehydic acid; oxaldehydic acid hydrate; Oxalic acid [ACD/IUPAC Name] [Wiki]; OXD; Oxo-acetic acid; OXOETHANOIC ACID; Oxoethanoic acid monohydrate; UNII:JQ39C92HH6; UNII-JQ39C92HH6; WLN: VHVQ; ?-ketoacetic acid; ?-ketoacetic acid; ?-Ketoacetic acid; ??? [Chinese]; Acetic acid, 2-oxo-, hydrate (1:1) [ACD/Index Name]; Acide oxoacétique, hydrate (1:1) [French] [ACD/IUPAC Name]; Glyoxylic acid monohydrate [Wiki]; Oxoacetic acid hydrate (1:1) [ACD/IUPAC Name]; Oxoessigsäurehydrat (1:1) [German] [ACD/IUPAC Name]; [563-96-2]; 1152495-30-1 [RN]; 206-058-5 [EINECS]; 298-12-4 [RN]; 2-Methylpropanamide [ACD/IUPAC Name]; 2-Oxoacetic Acid; 2-Oxoacetic acid hydrate; 2-Oxoacetic acid monohydrate; 2-Oxoethanoic acid monohydrate; 563-96-2 [RN]; 6000-59-5 [RN]; formylformic acid; Formylformic acid monohydrate; Glyoxalic acid; glyoxalic acid hydrate; Glyoxalic acid hydrate;Glyoxylic acid monohydrate; Glyoxalic Acid Monohydrate; Glyoxylic Acid Hydrate; Glyoxylic acid monohydrate, Formylformic acid monohydrate, 2-Oxoethanoic acid monohydrate; Glyoxylic acid monohydrate; Formylformic acid monohydrate; 2-Oxoethanoic acid monohydrate; Glyoxylic acid monohydrate; Formylformic acid monohydrate; 2-Oxoethanoic acid monohydrate; 563-96-2 (diol); glyoxylicacidhydrate; Glyoxylicacidmonohydrate; oxaldehydic acid and hydrate; oxoacetate monohydrate; oxoacetic acid hydrate; Oxoacetic acid monohydrate;Oxoacetic acid–water (1/1); OXOETHANOIC ACID; QA-1237; glyoxylic; InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5);GA;OCHCOOH;Glyoxalate;glyoxylate;Glyoxylsure;Formylformic;oxo-aceticaci;GLYOXALIC ACID;GLYOXYLIC ACID;oxo-acetic acid; CHEBI:42767, CHEBI:5509, CHEBI:24421; InChI?=?1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5); InChIKey?=?HHLFWLYXYJOTON-UHFFFAOYSA-N; Glyoxylic acid monohydrate for synthesis. ; Oxoethanoic acid, Oxoacetic acid, Acetic acid, Oxo-, Glyoxalic acid; Glyoxylic acid; glyoxylic acid; oxaldehydic acid; glyoxalate; glyoxylic acid; oxoacetic acid glyoxalic acid; Exchange reactions, glyoxal oxidation, glyoxylic acid, selective separation, sodium glyoxylate; Glyoxylic acid … ; Glyoxylic Acid Monohydrate 98%; oxoacetic acid; Glyoxylic oxime acid, bis(trimethylsilyl)-; InChI=1S/C8H19NO3Si2/c1-13(2,3)11-8(10)7-9-12-14(4,5)6/h7H,1-6H3; Glyoxylic acid, oxime, bis-TMS; Glyoxylic acid, oxime, di-TMS; Glyoxylic oxime, bis-TMS; Glyoxylic oxime, (2TMS); Glyoxylic oxime, TMS; Glycolic acid, oxime, TMS; Oximated glyoxylic acid, diTMS; Glyoxylic Acid ;GLYOXALIC ACID; GLYOXALC ACD; GLYOXALIK ACD; GLYOKSALL ASD; GLYOKSAL; GLOKSAL; GLIOKSAL ASIT; GLYOXAL ACID; GLOXAL ACD; GLYOKSAL ACID; GLYOXAL ASD; ASID; glyoksal asid; glioksal asid; glyoksal asid; glyoxal acd; glyoxal acid; glioksal asit; glyoksal ast; asd; glioksal asd; gloksal asd; glioksal asid; glyoxal acid;lyoxylic Acid (GXA) is a colorless solid and a highly reactive chemical intermediate having two functional groups: an aldehyde group and a carboxylic acid group.Glyoxylic Acid is soluble in water and ethanol, slightly soluble in organic solvents like ether or benzene, and insoluble in esters aromatic solvents.Aqueous solutions of Glyoxylic Acid are transparent, colorless or light yellow liquids.GXA is a strong organic acid (Ka=4.7×10-4), and due to its bifunctionality serves as an important C2 building block for many organic molecules of industrial importance. GXA is e.g. used in the production of agrochemicals, aromas, cosmetic ingredients, pharmaceutical intermediates and polymers.Glyoxylic Acid finds application in personal care as neutralizing agent, it is widely used in hair straightening products in particular (shampoos, conditioners, lotions, creams) at levels of 0.5-10%.
Properties of glyoxylic acid
Molecular Formula:C2H2O3
Molecular Weight:74.035 g/mol
Density 1.34 g/cm3 (20 °C)
Glyoxylic acid or oxoacetic acid is an organic compound that is both an aldehyde and a carboxylic acid. Glyoxylic acid is a liquid with a melting point of -93°C and a boiling point of 111°C. It is an intermediate of the glyoxylate cycle, which enables certain organisms to convert fatty acids into carbohydrates. The conjugate base of glyoxylic acid is known as glyoxylate (PMID: 16396466 ). In humans, glyoxylate is produced via two pathways: (1) through the oxidation of glycolate in peroxisomes and (2) through the catabolism of hydroxyproline in mitochondria. In the peroxisomes, glyoxylate is converted into glycine by glyoxylate aminotransferase (AGT1) or into oxalate by glycolate oxidase. In the mitochondria, glyoxylate is converted into glycine by mitochondrial glyoxylate aminotransferase AGT2 or into glycolate by glycolate reductase. A small amount of glyoxylate is converted into oxalate by cytoplasmic lactate dehydrogenase. Glyoxylic acid is found to be associated with primary hyperoxaluria I, which is an inborn error of metabolism. Under certain circumstances, glyoxylate can be a nephrotoxin and a metabotoxin. A nephrotoxin is a compound that causes damage to the kidney and kidney tissues. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. High levels of glyoxylate are involved in the development of hyperoxaluria, a key cause of nephrolithiasis (commonly known as kidney stones). Glyoxylate is both a substrate and inductor of sulfate anion transporter-1 (SAT-1), a gene responsible for oxalate transportation, allowing it to increase SAT-1 mRNA expression, and as a result oxalate efflux from the cell. The increased oxalate release allows the buildup of calcium oxalate in the urine, and thus the eventual formation of kidney stones. As an aldehyde, glyoxylate is also highly reactive and will modify proteins to form advanced glycation products (AGEs).
Glyoxylic acid (GA) is a colourless solid that occurs naturally and is useful industrially. Aqueous solution of Glyoxylic acid is transparent colorless or light yellow liquid. Soluble in water and ethanol, slightly soluble in organic solvents like ether or benzene, insoluble in esters aromatic solvents. This solution is not stable but will not decay in the air.
GA is a strong organic acid and a highly reactive chemical intermediate having two functional groups: the aldehyde group and the carboxylic acid group. Because of its bi-functionality is a versatile reagent in organic and fine chemicals syntheses.
Applications:
Electroless Copper Plating
Glyoxylic Acid can be used as an alternative reducing agent for electroless copper plating. Plating rates and bath stability were superior to that of the formaldehyde bath under standard conditions. Glyoxylate ions in the plating bath have no vapor pressure and show good reducing power in the electroless copper plating. Therefore, glyoxylic acid can replace formaldehyde, and eliminate health and environmental problems resulting from generation of the fumes.
Biogenic Amines Visualizer
GXA can undergo various condensation reactions and thus is commonly used for visual detection of biogenic amines in histological sections. This is the sucrose-phosphate-glyoxylic acid (SPG) histofluorescence method for the visualization of monoamines in tissues where the fluorescence is analyzed by fluorescence microscopy. It is used for counterstaining tissues.
Fungicides
GXA derivatives have been described as a new class of Oomycete fungicides. The GXA derivatives exhibit specific activity against oomycetes, including dwony mildew on grapes (Plasmopara viticola) and late blight on potatoes an tomatoes (Phytophthora infestans). They are active against Oomycetes in soil such as Phytophthora in tabacoo and citrus. They exhibit protective, curative, eradicative and antisporulant activity. This class of compounds can be synthesized via a simple synthetic approach where in the second step the glycolic acid ester is needed.
Pharmaceuticals
Gloxylic Acid is either a raw material or used as an intermediate in the synthesis of various pharmaceutical products like D,L-p-hydroxyphenylglycine, D,L-p-hydroxyphenylhydantoin, orotic aid, sulindac, mandelic acid, p-hydroxyphenylacetic acid, diphenylacetic acid, Lamivudine and 4-Aminophenylacetic acid.
Agrochemicals
Glyoxylic Acid is used as a key raw material for the synthesis of e.g. Ethylene bis(hydroxyphenyl)glycine, glyphosate, 2-hydroxy quinoxaline and complexing agents like EDDHA.
Flavor and Fragrance Products
Glyoxylic Acid can be used as a key raw material for different aromas such as vanillin, ethyl vanillin and heliotropin.
Personal Care Products Ingredients
A very prominent product produced from GXA is Allantoin which is used to a great extent in cosmetics. It can be considered as the diureide of Glyoxylic Acid and is highly active in skin-softening (keratolytic effect) and rapid cell regeneration by precipitating proteins on skin.
Glikoksilik asitin özellikleri
Moleküler Formül: C2H2O3
Moleküler Arlk: 74.035 g / mol
Younluk 1,34 g / cm3 (20 ° C)
Glioksilik asit veya oksoasetik asit, hem bir aldehit hem de bir karboksilik asit olan organik bir bileiktir. Glyoxylic asit -93 ° C erime noktasna ve 111 ° C kaynama noktasna sahip bir svdr. Baz organizmalarn ya asitlerini karbonhidratlara dönütürmesini salayan glioksilat döngüsünün bir ara ürünüdür. Glikoksilik asitin konjuge taban, glioksilat (PMID: 16396466) olarak bilinir. nsanlarda, glioksilat iki yolla üretilir: (1) peroksizomlarda glikolatn oksidasyonu ve (2) mitokondriyadaki hidroksiprolinin katabolizmas. Peroksizomlarda, glioksilat, glioksilat aminotransferaz (AGT1) veya glikolat oksidaz ile oksalat ile glisin haline dönütürülür. Mitokondride, glioksilat, glikoz içine mitokondriyal glioksilat aminotransferaz AGT2 veya glikolat ile glikolat redüktaz ile dönütürülür. Az miktarda glioksilat, sitoplazmik laktat dehidrogenaz ile oksalat haline dönütürülür. Glyoxylic asit, metabolizmann doutan gelen bir hatas olan primer hyperoxaluria I ile ilikili bulunmutur. Belirli koullar altnda, glioksilat bir nefrotoksin ve bir metabotoksin olabilir. Bir nefrotoksin, böbrek ve böbrek dokularna zarar veren bir bileiktir. Metabotoksin kronik olarak yüksek seviyelerde olumsuz salk etkilerine neden olan endojen olarak üretilmi bir metabolittir. Yüksek düzeyde glioksilat, nefrolitiazisin (genellikle böbrek talar olarak bilinir) temel bir nedeni olan hiperoksalurinin geliiminde rol oynar. Glyoksilat, hem bir substrat ve hem de oksalat tanmasndan sorumlu bir gen olan sülfat anyonu taycs-1 (SAT-1) indüktörünün bir indükleyicisidir ve SAT-1 mRNA ekspresyonunu ve bunun sonucunda hücreden oksalat akntsn arttrr. Artan oksalat salm, idrarda kalsiyum oksalatn birikmesine ve böylelikle de böbrek talarnn olumasna izin verir. Bir aldehit olarak, glioksilat da oldukça reaktiftir ve proteinleri gelimi glikasyon ürünleri (AGE’ler) oluturmak üzere deitirecektir.
Glioksilik asit (GA), doal olarak oluan ve iyonu ile olan renksiz bir katdr. Glisoksilik asitin sulu çözeltisi saydam renksiz veya açk sar bir svdr. Suda ve etanolde çözünür, eter veya benzen gibi organik çözücüler içinde az çözünür, esterler aromatik çözücüler içinde çözmez. Bu çözelti olumuyor, havada bozunmayacak.
GA, güçlü bir organik asit ve iki kimyasal madde içeren bir kimyasal madde maddesi: aldehit grubu ve karboksilik asit grubu. ki bileenli organik ve ince kimyasallar sentezlerinde çok yönlü bir reaktiftir.
Uygulamalar:
Akmsz Bakr Kaplama
Glyoxylic Acid, elektriksiz bakr kaplama için alternatif bir indirgeyici ajan olarak kullanlabilir. Kaplama oranlar ve banyo stabilitesi, standart koullar altnda formaldehit banyosununkinden daha üstündür. Kaplama banyosundaki glioksilat iyonlar, buhar basncna sahip deildir ve elektriksiz bakr kaplamada iyi bir indirgeme gücü gösterir. Bu nedenle, glioksilik asit formaldehitin yerine geçebilir ve duman oluumundan kaynaklanan salk ve çevre sorunlarn ortadan kaldrabilir.
Biyojenik Aminler Görüntüleyici
GXA çeitli younlama reaksiyonlarna girebilir ve bu nedenle histolojik kesitlerde biyojenik aminlerin görsel olarak tespitinde yaygn olarak kullanlr. Bu floresan floresan mikroskobu ile analiz edildii dokularda monoaminlerin görselletirme için sükroz-fosfat-glioksilik asit (SPG) histofluoresans yöntemidir. Dokular saymak için kullanlr.
Mantar ilaçlar
GXA türevleri yeni bir Oomycete fungisit snf olarak tanmlanmtr. GXA türevleri, üzümlerde (Plasmopara viticola) dwoni küfü ve patateslerde bir yankl (Phytophthora infestans) içeren oomiselere kar spesifik aktivite gösterir. Tacoco ve narenciyede Phytophthora gibi topraktaki Oomisetlere kar aktiftirler. Koruyucu, iyiletirici, eradikatif ve antisporulan aktivitesi sergilerler. Bu bileik snf, ikinci aamada glikolik asit esterinin gerekli olduu basit bir sentetik yaklamla sentezlenebilir.
laç
Gloxylic Acid ya bir ham maddedir veya D, Lp-hidroksifenilglisin, D, Lp-hidroksifenilhidantoin, orotik yardm, sulindak, mandelik asit, p-hidroksifenilasetik asit, difenilasetik asit, Lamivudin gibi çeitli farmasötik ürünlerin sentezinde bir ara madde olarak kullanlr. 4-Aminofenilasetik asit.
Tarmsal Kimyasallar
Glyoxylic Acid, örn. Etilen bis (hidroksifenil) glisin, glifosat, 2-hidroksi kinoksalin ve EDDHA gibi kompleksletirici ajanlar.
Lezzet ve Koku Ürünleri
Glyoxylic Acid, vanilin, etil vanilin ve heliotropin gibi farkl aromalar için önemli bir hammadde olarak kullanlabilir.
Kiisel Bakm Ürünleri Malzemeler
GXA’dan üretilen çok önemli bir ürün, büyük ölçüde kozmetikte kullanlan Allantoin’dir. Glyoxylic Acid diüriti olarak düünülebilir ve ciltte yumuatc (keratolitik etki) ve hzl hücre rejenerasyonunda yüksek oranda aktiftir.