HOMOSALATE
Homosalate is a chemical compound commonly used in cosmetics and sunscreens as an ultraviolet (UV) filter, offering protection against sun-induced skin damage.
Homosalate specifically absorbs short-wave UVB rays, which are associated with DNA damage and an increased risk of skin cancer.
While effective in UVB protection, Homosalate must be combined with other sunscreen agents for broad-spectrum coverage against both UVA and UVB rays.
CAS Number: 118-56-9
EC Number: 204-260-8
Molecular Formula: C16H22O3
Molecular Weight: 262.35 g/mol
Synonyms: Homosalate, 118-56-9, Homomenthyl salicylate, Coppertone, 3,3,5-TRIMETHYLCYCLOHEXYL SALICYLATE, Heliopan, Heliophan, Filtersol ”A”, 3,3,5-Trimethylcyclohexyl 2-hydroxybenzoate, m-Homomenthyl salicylate, Homosalatum, Homosalato, (3,3,5-trimethylcyclohexyl) 2-hydroxybenzoate, Caswell No. 482B, Benzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl ester, 52253-93-7, CCRIS 4885, NSC 164918, Metahomomenthyl salicylate, Salicylic acid, m-homomenthyl ester, EINECS 204-260-8, 2-Hydroxybenzoic acid 3,3,5-trimethylcyclohexyl ester, UNII-V06SV4M95S, Salicylic Acid 3,3,5-Trimethylcyclohexyl Ester, EPA Pesticide Chemical Code 076603, NSC-164918, V06SV4M95S, MFCD00019377, Homosalate [USAN], DTXSID1026241, EC 204-260-8, Salicylic acid, 3,3,5-trimethylcyclohexyl ester, NCGC00091888-01, Homosalatum (INN-Latin), Homosalato (INN-Spanish), HOMOSALATE (MART.), HOMOSALATE [MART.], HOMOSALATE (USP-RS), HOMOSALATE [USP-RS], Homosalate (USAN), DTXCID606241, Salicylic acid, 3,3,5-trimethylcyclohexyl ester (8CI), HOMOSALATE (USP IMPURITY), HOMOSALATE [USP IMPURITY], HOMOSALATE (USP MONOGRAPH), HOMOSALATE [USP MONOGRAPH], Filtrosol A, component of Coppertone, SR-05000001884, Homosalat, Kemester HMS, CAS-118-56-9, Homosalate; Salicylic acid 3,3,5-trimethylcyclohexyl ester; 3,3,5-Trimethylcyclohexyl salicylate, Filtersol”A”, HOMOSALATE [MI], Homosalate (USP/INN), HOMOSALATE [INN], Prestwick1_001090, Prestwick2_001090, Prestwick3_001090, HOMOSALATE [USAN], HOMOSALATE [WHO-DD], SCHEMBL16207, BSPBio_001140, SPECTRUM1505020, SPBio_003030, BPBio1_001254, Sun Protection Facial SPF 50, CHEMBL1377575, CHEBI:91642, 3,5-Trimethylcyclohexyl salicylate, HMS1571I22, HMS2093G22, HMS2098I22, HMS3715I22, Pharmakon1600-01505020, 98.0%, mixture of cis and trans, component of Coppertone (Salt/Mix), HY-B0928, 3,3,5-Trimethylcyclohexylsalicylate, Tox21_111174, Tox21_202109, Tox21_303082, NSC164918, NSC758908, s4572, AKOS015904082, Tox21_111174_1, CCG-213330, DB11064, NSC-758908, NCGC00091888-02, NCGC00091888-03, NCGC00091888-04, NCGC00091888-05, NCGC00091888-06, NCGC00091888-09, NCGC00257063-01, NCGC00259658-01, AS-10409, SY051923, SBI-0206787.P001, AB00514041, NS00009551, Salicylic acid,3,5-trimethylcyclohexyl ester, T2278, Benzoic acid, 3,3,5-trimethylcyclohexyl ester, D04450, E78223, AB00514041_02, EN300-7381967, A921433, J-519754, Q2260189, SR-05000001884-1, SR-05000001884-2, BRD-A34751532-001-03-6, BRD-A34751532-001-04-4, 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester, Homosalate, United States Pharmacopeia (USP) Reference Standard, Homosalate, Pharmaceutical Secondary Standard; Certified Reference Material, 3,3,5-trimethycyclohexyl salicylate, HMS, HMS, HOMOMENTHYL SALICYLATE, Heliopan, 3,3,5-TRIMETHYLCYCLOHEXYL SALICYLATE, Benzoicacid,2-hydroxy-,3,3,5-trimethylcyclohexylester, Homosalat, HELIOPHAN, omosalate, Coppertone, HOMOSALATE
Homosalate is an active sunscreen ingredient that protects skin from UVB rays, which leads to sun damage.
Homosalate is a colorless, transparent and viscous liquid.
Homosalate is well soluble in water.
Homosalate is a synthetic sunscreen ingredient and UVB protector.
Research indicates Homosalate is a weak hormone disruptor, forms toxic metabolites, and can enhance the penetration of a toxic herbicide.
Homosalate is a chemical compound commonly used in cosmetics and sunscreens as an ultraviolet (UV) filter, offering protection against sun-induced skin damage.
Apart from this, Homosalate enhances the overall stability of sunscreen formulations.
Homosalate is versatile and popular for its light, non-greasy texture, making it a preferred choice in various skincare products.
While effective in UVB protection, Homosalate is important to note that Homosalate primarily addresses shorter-wavelength UV rays, necessitating the combination with other sunscreen agents for broad-spectrum coverage against both UVA and UVB rays.
Additionally, Homosalate also goes by the name homomenthylsalicylate and has the chemical formula C16H22O3.
Homosalate is an active sunscreen ingredient that protects skin from UVB rays, which leads to sun damage.
Homosalate is an FDA-approved sunscreen active ingredient that provides primarily UVB protection, stopping where the UVA range begins.
Homosalate’s internationally approved for use in sunscreens, up to a maximum concentration of 15%.
Turning to safety, studies have shown that homosalate has low penetration into skin, is not an endocrine disruptor, and is unlikely to provoke an allergic reaction on skin.
In vitro studies on breast cancer cells have shown that homosalate has cytotoxic effects; however, this does not apply to how sunscreen is used on skin, and the amounts shown to provoke this effect are much greater than what could be absorbed into the body from topical application.
Homosalate is an oil-soluble chemical sunscreen agent that protects the skin from UVB (295-315 nm) with a peak protection at 306 nm.
Homosalate is not a strong UV filter in and of itself (gives only SPF 4.3 protection at max. allowed 10% concentration) and Homosalate is not photostable (looses 10% of its SPF protection in 45 mins) so Homosalate always has to be combined with other sunscreens for proper protection.
Its big advantage, though, is that Homosalate is a liquid and is excellent for dissolving other hard to solubilize powder sunscreen agents, like the famous Avobenzone.
Homosalate is a colorless to pale yellow liquid.
Homosalate is soluble in all relevant cosmetic oils.
Homosalate is an organic compound that belongs to a class of chemicals called salicylates.
Salicylates prevent direct skin exposure to the sun’s harmful rays by absorbing ultraviolet (UV) light.
Homosalate specifically absorbs short-wave UVB rays, which are associated with DNA damage and increased risk of skin cancer.
Homosalate is a colorless, transparent and viscous liquid.
Homosalate is well soluble in water.
Homosalate is a UV filtering agent used especially in sunscreen products.
Homosalate provides protection against UVB (Ultraviolet B) rays and reduces the risk of sunburn by preventing the skin from being exposed to such rays.
The usage rate of Homosalate varies between 2% and 15% depending on the effect of the product and its interaction with other compounds.
Homosalate belongs to the class of chemicals known as salicylates and is organic.
Homosalate is a synthetic.
Homosalate (Homomenthyl salicylate) is an organic compound used as a sunscreen to filter UV rays and protect the skin from sun damage.
Homosalate has anti-inflammatory activity.
Homosalate is an effective oil-soluble liquid UV-B absorber.
Homosalate is an excellent solubilizer for crystalline UV absorbers such as Avobenzone or Ethylhexyl Triazone.
Homosalate, or homomenthyl salicylate, is an organic compound in the salicylates class of chemicals.
Homosalate’s used in some sunscreens due to its UV-absorption properties, protecting against the sun’s harmful rays by absorbing UVB rays, which are associated with DNA damage and increased risk of skin cancer.
Homosalate is a synthetic UV filter used in sunscreen and other skin care products to absorb and filter out UVB radiation.
Homosalate is a derivative of salicylic acid.
Homosalate is an oil-soluble chemical sun-blocking agent that absorbs UVB radiation.
However, homosalate degrades more quickly (losing 10% of SPF protection in 45 minutes) when exposed to higher UV light.
The mechanism of action of Homosalate is a process known as “photoprotection.”
This process involves the absorption of UV radiation by the Homosalate molecules, which causes them to undergo a structural change.
This structural change of Homosalate allows the molecules to absorb and filter out UVB radiation, protecting them from UV damage.
Homosalate has the ability to solubilize oxybenzone and avobenzone.
Because homosalate only covers the UVB spectrum, it is usually combined with avobenzone (a chemical UVA filter) to get broad-spectrum coverage.
Like most chemical sunscreens ingredients, homosalate absorbs into the skin.
Homosalate does not sit on top of the skin like zinc oxide.
Homosalate is an organic compound used in some sunscreens.
Homosalate is made by the Fischer–Speier esterification of salicylic acid and 3,3,5-trimethylcyclohexanol, the latter being a hydrogenated derivative of isophorone.
Homosalate is an organic compound belonging to a class of chemicals known as salicylates.
Homosalate’s a chemical sunscreen that shields the skin from sun exposure by absorbing UV light and converting it to heat so that it can’t cause DNA damage to the skin cells.
There are plenty of other chemical sunscreen ingredients, but homosalate is incredibly common.
In fact, Homosalate’s found in almost half of commercially-available sunscreens, notes Fincher.
Homosalate is an organic compound that belongs to salicylates.
Homosalate is an ester formed from salicylic acid and 3,3,5-trimethylcyclohexanol, a derivative of cyclohexanol.
Salicylates prevent direct skin exposure to the sun’s harmful rays by absorbing ultraviolet (UV) light.
Homosalate specifically absorbs short-wave UVB rays, which are associated with DNA damage and increased risk of skin cancer.
Homosalate is a common ingredient in many commercially available sunscreens.
There are no reported adverse effects from homosalate.
Homosalate appears as viscous or light yellow to slightly tan liquid or oil.
Homosalate ester is a benzoate ester and a member of phenols.
Homosalate is functionally related to a salicylic acid.
Homosalate is an organic compound that belongs to salicylates.
Homosalate is an ester formed from salicylic acid and 3,3,5-trimethylcyclohexanol, a derivative of cyclohexanol.
Salicylates prevent direct skin exposure to the sun’s harmful rays by absorbing ultraviolet (UV) light.
Homosalate specifically absorbs short-wave UVB rays, which are associated with DNA damage and increased risk of skin cancer.
Homosalate is a common ingredient in many commercially available sunscreens.
There are no reported adverse effects from homosalate.
Homosalate is a natural product found in Camellia sinensis with data available.
Homosalate is an organic sun filter (from carbon).
This filter mainly absorbs UVB radiation, which is responsible for tanning but also for sunburn and skin cancer.
Homosalate is a salicylate compound commonly used as an active ingredient in cosmetic sunscreens to reduce the photodegradation of other active sunscreen ingredients.
The SCCP has concluded that the use of homosalate at a maximum concentration of 10%w/w in cosmetic sunscreen does not pose a risk to the health of the consumer.
Homosalate is a liquid.
Homosalate is a homolog of menthyl salicylate.
Homosalate is a viscous or light yellow to slightly tan liquid or oil.
Homosalate is an ingredient used in sunscreens and fragrances.
Homosalate is a UV-absorber, filter, and a skin condition.
Homosalate absorbs UVB rays specifically.
Homosalate is a coumarin derivative that is used as an active ingredient in sunscreens.
Homosalate absorbs the radiation of UV light and transforms it into harmless heat.
Homosalate has been shown to be effective against skin cancer cells in vivo, but does not have any effect on the growth of bacteria.
Contained in 45% of U.S. sunscreens, Homosalate is used as a chemical UV filter.
The salicylic acid portion of the molecule absorbs ultraviolet rays with a wavelength from 295 nm to 315 nm, protecting the skin from sun damage.
The hydrophobic trimethyl cyclohexyl group provides greasiness that prevents it from dissolving in water.
Homosalate is an oil-soluble organic sunscreen used to protect the skin from UVB rays (295-315 nm), with peak protection at 306 nm.
Homosalate’s an older, unstable sunscreen dating from 1978 (part of the reason why sunscreens need to be reapplied frequently is the instability of older chemical sunscreens).
As such, homosalate is not a powerful UV filter (Homosalate only offers SPF protection of 4.3 at a maximum permitted concentration of 10 %) and is not photostable (Homosalate loses 10 % of its SPF protection in 45 minutes), so it must always be combined with other sunscreens for adequate protection.
Homosalate also acts as a solvent for UV filters that are more difficult to dissolve, such as the well-known avobenzone.
Homosalate is an organic compound that forms an ester from salicylic acid, and appears as a yellowish-tan liquid or oil.
Uses of Homosalate:
Homosalate serves sunscreens and cosmetics primarily as a chemical UV filter.
Homosalate absorbs the UV rays, specifically UVB rays, that are known to cause sunburn and contribute to sun damage.
These harmful rays can also cause the skin to tan and sometimes lead to skin cancer.
Homosalate is a stable ingredient that works its magic against UV rays for longer durations.
Indirectly, Homosalate also acts as an anti-aging compound for the skin – maintaining its health and keeping it youthful.
However, Homosalate is not strong enough to be used independently and is often combined with other ingredients to maximize protection.
Homosalate is used as a UV filter in various personal skin care formulations and cosmetics.
Homosalate is used UV screen, analgesic.
Homosalate is a chemical uVB absorber included in the FDA’s Category I Sunscreen Chemical list.
Homosalate’s approved usage level is 4 to 15 percent by the FDA and 10 percent by the european union’s Cosmetic Directive.
Homosalate functions as both a UV protector and a UV filter by absorbing UV rays.
Since the UVA-protecting range of homosalate is very narrow, it’s not used alone in sunscreens, but is often used with UVA filters such as avobenzone, where Homosalate can help improve stability.
Homosalate’s considered non-sensitizing and is most often seen in sunscreens rated SPF 30 and greater.
Interestingly, since homosalate is a salicylate ingredient just like salicylic acid, part of how it works to reduce signs of UV-triggered redness is from its calming benefit.
Some researchers speculate that this could mean people stay out in the sun longer since they won’t see their skin turn color, but since homosalate is never used alone and the redness-producing damage it offsets is a benefit, it’s not considered a valid concern.
Other studies have shown that homosalate suppresses the formation of a type of free radical known as singlet oxygen which is formed when skin is exposed to UV light.
Homosalate is a widely used chemical in sunscreens and skin care products with SPF.
Homosalate is a potential endocrine disruptor and studies in cells suggest it may impact hormones.
In addition to direct health concerns following homosalate exposure, the chemical may also enhance the absorption of pesticides in the body.
Cosmetics and personal care products containing UV filters are used worldwide to protect skin from UV rays, which is one of the factors that cause skin cancer and skin aging, and to maintain skin health.
Homosalate is used in cosmetics as a UV absorber to protect the skin from UV rays and as a stabilizer to prevent deterioration of product quality due to UV exposure.
Homosalate is used in sunscreens, skin care products, and so on.
Homosalate is also a potent antimicrobial agent and can be used for wastewater treatment.
The monosodium salt of homosalate is synthesized from gyrophoric acid and sodium salicylate by heating them together in the presence of water.
The resulting product can then be purified by crystallization or recrystallization methods.
Analytical methods for homosalate include synchronous fluorescence and anhydrous sodium sulfite precipitation with sulfuric acid.
Homosalate is used inhibition Assay (InhA), Functional Studies (Func).
Homosalate a powerful oil-soluble UV-B filter and anti-aging agent perfect for your skincare needs.
Designed to absorb UV-B rays effectively, Homosalate provides reliable protection while seamlessly incorporating into a wide range of products.
Not only does Homosalate safeguard your skin, but it also serves as an excellent solubilizer for other crystalline UV filters like butyl methoxydibenzoylmethane or ethyl hexyl triazone.
Ideal for formulating sunscreens, hand and face lotions, makeup creams, and hair care products, Homosalate offers versatility and efficacy across various applications.
With a shelf-life of 2 years, Homosalate ensures long-lasting quality and performance for your skincare routine.
Homosalate is an ingredient used in the formulation of sunscreen products.
Homosalate is also used in some eyebrow pencils, skincare, and lipsticks.
Homosalate is used mainly as a sunscreen ingredient, protecting the skin against UV rays.
Another way in which homosalate is used is to protect ingredients in other formulations from degrading or absorbing UV rays.
Homosalate does this by converting UV rays into less damaging infrared heat.
Homosalate is commercially used in as many as 45% of all chemical sunscreen products in the United States due to its ability to protect the skin from the sun’s ultraviolet (UV) radiation.
Being amongst one of the safe sunscreen ingredients for UVB protection, homosalate helps to prevent against sunburn and photo-damage that may lead to the formation of premature signs of aging (i.e., fine lines and wrinkles).
Moreover, use of homosalate in sunscreen products is considered non-toxic and presents no signs or evidence of causing negative side effects.
Sunscreens are used to protect the skin from the harmful effects of the sun.
They help to prevent sunburn and premature aging (such as wrinkles, leathery skin).
Sunscreens also help to decrease the risk of skin cancer and also of sunburn-like skin reactions (sun sensitivity) caused by some medications (including tetracyclines, sulfa drugs, phenothiazines such as chlorpromazine).
The active ingredients in sunscreens work either by absorbing the sun’s ultraviolet (UV) radiation, preventing Homosalate from reaching the deeper layers of the skin, or by reflecting the radiation.
Wearing sunscreen does not mean that you can stay out longer in the sun.
Sunscreens cannot protect against all of the sun’s radiation.
There are various types of sunscreens available in many forms (such as cream, lotion, gel, stick, spray, lip balm).
Use in Personal Care:
Homosalate is not a strong UV filter in and of itself (gives only SPF 4.3 protection at max. allowed 10% concentration).
This sunscreen agent, Homosalate, protects the skin from UVB (295-315 nm) with a peak protection at 306 nm.
Homosalate is a common chemical ingredient in some sunscreen and lip balm brands that protect the skin against harmful UVB radiation.
Homosalate can be combined with other sunscreens for wide-spectrum protection and has excellent dissolving properties for solid sunscreens.
In the U.S., homosalate is a Category 1 UV filter permitted for over-the-counter (OTC) human use.
UV Protector uses:
Homosalate, when applied to the skin, absorbs UV rays, offering sun protection.
In addition to causing sunburn, UV radiation is a significant cause of premature skin aging and contributes to the development of melanoma and other forms of skin cancer.
Homosalate can also protect cosmetics and personal care products from deterioration by absorbing UV rays.
UV Filter uses:
As a chemical sunscreen, otherwise known as an organic UV filter, homosalate is an aromatic compound.
Homosalate’s molecular structure is responsible for absorbing UVB energy.
Homosalate absorbs UVB rays, which produce excitation of the sunscreen chemical to a higher energy state.
Then, they return to the ground state and convert the absorbed energy into longer, lower energy wavelengths (heat).
In Personal Care Products:
Homosalate is an oil-soluble chemical sun-blocking agent that absorbs UVB radiation.
Homosalate’s commonly used in formulations of high-SPF sunscreen products.
Background information on use in cosmetics:
Homosalate is a soluble organic UV-B filter.
Homosalate absorbs UV-B radiation from approximately 280 to 320 nm.
The maximum concentration of homosalate is 7.3 %.
Benefits of Homosalate:
There isn’t a huge difference between the various chemical sunscreen ingredients, all of which work the same way.
The differences lay in terms of which specific UV rays they can absorb and protect against.
UVB-blocker:
Homosalate, in particular, is a UVB-blocker, protecting against the UV damage that is known to cause skin cancer.
To that point, “since Homosalate has very limited efficacy against UVA rays, Homosalate needs to be combined with other agents to ensure complete protection in broad-spectrum.
Broad-spectrum sunscreen ingredient:
Homosalate’s this combination of chemical sunscreen ingredients, some of which work against UVA rays and some of which work against UVB rays, that will offer a larger range of protection so that a sunscreen can be called “broad-spectrum.
Functions of Homosalate:
Masking:
Homosalate reduces or inhibits the odor or basic taste of the product
Uv Absorber:
Homosalate protects the cosmetic product from UV-light effects
Uv Filter:
Homosalate filters certain UV rays to protect the skin or hair from the harmful effects of these rays.
As a chemical sunscreen, otherwise known as an organic UV filter, homosalate is an aromatic compound.
Homosalate’s molecular structure is responsible for absorbing UVB energy.
Homosalate absorbs UVB rays, which produce excitation of the sunscreen chemical to a higher energy state.
Then, they return to the ground state and convert the absorbed energy into longer, lower energy wavelengths (heat).
UV Protector:
Homosalate, when applied to the skin, absorbs UV rays, offering sun protection.
In addition to causing sunburn, UV radiation is a significant cause of premature skin aging and contributes to the development of melanoma and other forms of skin cancer.
Homosalate can also protect cosmetics and personal care products from deterioration by absorbing UV rays.
Production of Homosalate:
Homosalate is produced through the Fischer–Speier esterification of salicylic acid and 3,3,5-trimethylcyclohexanol, a hydrogenated derivative of isophorone.
The salicylic acid portion of the molecule absorbs ultraviolet rays with a wavelength from 295 nm to 315 nm, protecting the skin from sun damage.
The hydrophobic trimethyl cyclohexyl group provides greasiness that prevents Homosalate from dissolving in water.
Air And Water Reactions of Homosalate:
Homosalate will hydrolyze under basic conditions.
Homosalate is insoluble in water.
Occurrence In Cosmetics of Homosalate:
Homosalate is used as a UV filter in sunscreens and other cosmetics with UV protection (care products, decorative cosmetics)
Origin of Homosalate:
Homosalate is an ester that is made by the esterification of 3,3,5-trimethylcyclohexanol and salicylic acid.
The latter has the ability to absorb UV rays and protect the skin from damage.
Homosalate appears as a clear, colorless to pale yellow liquid and has a slight minty odor.
Homosalate is purified for use in the cosmetic industry.
Homosalate At A Glance:
A globally approved UV filter
Mostly protects within the UVB range
Serves as a solvent for other UV filters, making them easier to work with
Considered low risk for triggering an allergic reaction
Often seen in sunscreens with higher SPF ratings
Handling And Storage of Homosalate:
Conditions for safe storage, including any incompatibilities:
Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Stability And Reactivity of Homosalate:
Reactivity:
Homosalate is an ester and a phenol.
Esters react with acids to liberate heat along with alcohols and acids.
Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products.
Heat is also generated by the interaction of esters with caustic solutions.
Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Chemical stability:
Stable under recommended storage conditions.
Possibility of hazardous reactions:
No data available
Conditions to avoid:
No data available
Safety Profile of Homosalate:
Homosalate is generally considered safe for use when applied topically.
However, some concerns have been raised about Homosalate’s potential to penetrate the skin and disrupt hormone function, particularly when used in high concentrations.
While regulatory bodies permit Homosalate’s use within specified limits, individuals with sensitive skin may choose alternative sunscreens.
Homosalate should be avoided by pregnant women and babies.
Additionally, Homosalate is a vegan and halal ingredient.
Homosalate has a shelf life of 2-3 years.
First Aid Measures of Homosalate:
If inhaled:
If breathed in, move person into fresh air.
In case of skin contact:
Wash off with soap and plenty of water.
In case of eye contact:
Flush eyes with water as a precaution.
If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Indication of any immediate medical attention and special treatment needed:
No data available
Fire Fighting Measures of Homosalate:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Further information:
No data available
Accidental Release Measures of Homosalate:
Environmental precautions:
Do not let product enter drains.
Methods and materials for containment and cleaning up:
Keep in suitable, closed containers for disposal.
Exposure Controls/Personal Protection of Homosalate:
Personal protective equipment:
Eye/face protection:
Use equipment for eye protection.
Skin protection:
Handle with gloves.
Wash and dry hands.
Body Protection:
Impervious clothing
Respiratory protection:
Respiratory protection not required.
Control of environmental exposure:
Do not let product enter drains.
Identifiers of Homosalate:
CAS No: 118-56-9
IUPAC Name: 3,3,5-Trimethylcyclohexyl 2-hydroxybenzoate
EC No:204-260-8
Chemical formula: C16H22O3
CAS Number: 118-56-9
EC Number: 204-260-8
MDL number: MFCD00019377
Chem/IUPAC Name: Benzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl ester
Chemical formula: C16H22O3
NIST Chemistry Reference: Homosalate (118-56-9)
EPA Substance Registry System: 3,3,5-Trimethylcyclohexyl salicylate (118-56-9)
CAS Number: 118-56-9
Molecular Formula: C16H22O3
Molecular Weight (g/mol): 262.35
InChI Key: WSSJONWNBBTCMG-UHFFFAOYNA-N
IUPAC Name: 3,3,5-trimethylcyclohexyl 2-hydroxybenzoate
SMILES: CC1CC(CC(C)(C)C1)OC(=O)C1=CC=CC=C1O
Category: Small Molecules
Description: Homosalate
Purity: 99.38%
SMILES: C(OC1CC(C)(C)CC(C)C1)(=O)C2=C(O)C=CC=C2
Formula: C16H22O3
Properties of Homosalate:
Molar mass: 262.349 g·mol−1
Density: 1.05 g/cm3 (20 °C)
Melting point: < -20 °C
Boiling point: 181–185 °C
Chemical formula: C16H22O3
Molar mass: 262.349 g·mol−1
Density: 1.05 g/cm3 (20 °C)
Melting point: < -20 °C
Boiling point: 181–185 °C (358–365 °F; 454–458 K)
Solubility in water: 0.4 mg/L
Appearance at 25°C: Clear, colorless to pale yellow liquid
Molecular Weight: 262.344 g/mol
Solubility at 20°C: Miscible in ethanol, isopropyl myristate, and paraffin oil.
Immiscible in propylene glycol and water (solubility of 0.4 mg/L).
UV Absorbance (E 1%/1cm): 170 – 180 (at 305 nm)
Specific Gravity: 1.049 – 1.053
Refractive Index (n 20/D, 20°C): 1.516 – 1.519
Acid Value (potentiometric filtration, mg KOH/g): 0.0 – 1.0 max
Odor: Characteristic, slight mint odor
Shelf Life: 2-3 years
Additional Information:
CBNumber: CB2203124
Molecular Formula: C16H22O3
Molecular Weight: 262.34
MDL Number: MFCD00019377
MOL File: 118-56-9.mol
Boiling Point: 161-165°C (12 torr)
Density: 1.05
Vapor Pressure: 0.015 Pa at 25°C
Refractive Index: n20 1.516 to 1.518
Flash Point: 169 – 173°C
Storage Temperature: Inert atmosphere, Room Temperature
Solubility: Slightly soluble in chloroform and DMSO
pKa: 8.10±0.30 (Predicted)
Color: Colorless
Odor: Mild menthol at 100.00%
Water Solubility: BRN: 2731604
LogP: 6.27 at 25°C
FDA 21 CFR: 352.70
CAS DataBase Reference: 118-56-9
EWG’s Food Scores: 2-4
FDA UNII: V06SV4M95S
Solubility in water: 0.4 mg/L
XLogP3-AA: 5
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 3
Exact Mass: 262.15689456 g/mol
Monoisotopic Mass: 262.15689456 g/mol
Topological Polar Surface Area: 46.5Ų
Heavy Atom Count: 19
Complexity: 324
Undefined Atom Stereocenter Count: 2
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes