HYDROXYPROPYL METHYLCELLULOSE
Hydroxypropyl methylcellulose, also known as hypromellose, is a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments.
Hydroxypropyl methylcellulose is typically used as a thickener, binder, film former, and water retention agent, and it functions as an emulsifier, suspension aid, surfactant, lubricant, protective colloid, and emulsifier.
Hydroxypropyl methylcellulose is a clear, tasteless, vegetarian and vegan appropriate material, commonly used in supplement capsules, particularly in the UK and European markets.
CAS Number: 9004-65-3
EC Number: 618-389-6
Molecular Formula: C3H7O
Molar Mass: 59.08708
Synonyms: SIS17, 2374313-54-7, N’-Hexadecylthiophene-2-carbohydrazide, SIS-17, CHEMBL4777961, Hydroxypropyl methyl cellulose, C21H38N2OS, SIS 17; SIS17, DTXSID701238689, BCP31156, EX-A6309, ZUD31354, BDBM50565135, MFCD32201127, s6687, AKOS037649020, BS-16273, HY-128918, CS-0102230, D70091, 2-Thiophenecarboxylic acid, 2-hexadecylhydrazide, 2-hydroxypropyl Methyl Ether Cellulose, Carbohydrate Gum, Cellulose, 2-hydroxypropyl Methyl Ether, Cellulose, 2hydroxypropyl Methyl Ether, Hydroxypropyl Methycellulose, Hydroxypropyl Methylcellulose, Hydroxypropyl Methylcellulose 2208, Hydroxypropyl Methylcellulose 2906, Hydroxypropyl Methylcellulose 2910, Hypromellose, Methyl Hydroxypropyl Cellulose
Hydroxypropyl methylcellulose belongs to the group of cellulose ethers in which hydroxyl groups have been substituted with one or more of the three hydroxyl groups present in the cellulose ring.
Hydroxypropyl methylcellulose is the degree of substitution is 1.08 to 1.83 with the hydroxypropyl groups as the minor constituent.
Hydroxypropyl methylcellulose is white to off-white fibrous powder or granules.
Hydroxypropyl methylcellulose is soluble in water and some organic solvents.
Hydroxypropyl methylcellulose is insoluble in ethanol, the aqueous solution has surface activity, forms a thin film after drying, and undergoes a reversible transition from sol to gel in turn by heating and cooling.
Hydroxypropyl methylcellulose are water soluble polymers derived from cellulose.
Hydroxypropyl methylcellulose is typically used as thickeners, binders, film formers, and water retention agents.
Hydroxypropyl methylcellulose is also function as suspension aids, surfactants, lubricants, protective colloids, and emulsifiers.
In addition, solutions of Hydroxypropyl methylcellulose polymers thermally gel.
These polymers are prepared by reacting wood or cotton cellulose fibers with propylene oxide and methyl chloride in the presence of caustic soda.
Hydroxypropyl methylcellulose has a methoxyl content of 28-30% and a hydroxypropoxyl content of 7-12%.
Hypromellose (INN), short for Hydroxypropyl methylcellulose, is a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.
As a food additive, Hydroxypropyl methylcellulose is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin.
Hydroxypropyl methylcellulose’s Codex Alimentarius code (E number) is E464.
Hydroxypropyl methylcellulose stands for hydroxypropyl methylcellulose or hypromellose for short.
Hydroxypropyl methylcellulose is the material from which most supplement capsules are made.
Hydroxypropyl methylcellulose is a clear, tasteless, vegetarian and vegan appropriate material.
Hydroxypropyl methylcellulose is normally made by extraction from wood pulp.
Of course, there are plenty of other materials that supplement capsules can be made from.
Hydroxypropyl methylcellulose is by far the most common, but bovine gelatine capsules are still used occasionally, or there are more unusual options, such as pullulan, which is made from a tapioca extract.
Once upon a time, almost all vitamin capsules were made from bovine gelatin.
As vegetarianism and sustainability became more popular, market trends moved away from gelatin based capsules.
Today most supplement products in the UK and European market would be made from Hydroxypropyl methylcellulose.
Bovine gelatin tends to only be used in very lost cost products, or products where Hydroxypropyl methylcellulose would not matter that Hydroxypropyl methylcellulose is not vegetarian, such as a collagen capsule.
Hydroxypropyl methylcellulose is a synthetic polymer that is quite popular in cosmetics and personal care products.
Hydroxypropyl methylcellulose is a highly versatile ingredient that serves as a thickener, emulsifier, and stabilizer in formulations.
Hydroxypropyl methylcellulose can help in improving the texture and flow properties of products like lotions, creams and gels.
Hydroxypropyl methylcellulose also controls the release of active ingredients and acts as a film-forming agent, protecting the skin from environmental stressors.
In its raw form, Hydroxypropyl methylcellulose appears as a white to off-white odorless powder or granule that is soluble in cold water but insoluble in organic solvents.
The chemical formula of Hydroxypropyl methylcellulose is C56H108O30.
Hydroxypropyl methylcellulose is propylene glycol ether of methyl cellulose, hydroxypropyl and methyl combine with anhydrous glucose ring by ether bond.
Hydroxypropyl methylcellulose is white or pale white cellulose powder or particles.
Hydroxypropyl methylcellulose has different types of products, the methoxy and hydroxypropyl content ratio is different.
Hydroxypropyl methylcellulose is white or gray fibrous powder or particles.
Hydroxypropyl methylcellulose is soluble in water and some organic solvents and unsoluble in ethanol.
Aqueous solution has a surface activity, the formation of the film after drying, heated and cooled, in turn, from the sol to gel reversible transformation.
Hydroxypropyl methylcellulose is an odorless and tasteless, white or creamy-white fibrous or granular powder.
Hydroxypropyl methylcellulose is soluble in water (10 mg/ml).
However, Hydroxypropyl methylcellulose is very important to thoroughly disperse the particles in water with agitation before they will dissolve.
Otherwise, they will lump and form a gelatinous membrane around the internal particles, preventing them from wetting completely.
There are four dispersion techniques commonly used to prepare solutions of Hydroxypropyl methylcellulose: dispersion in hot water, dry blending, dispersion in non-solvent medium, and dispersion of surface-treated powders.
Hydroxypropyl methylcellulose is a water-soluble polymer derived from cellulose.
This polysaccharide forms colloids when dissolved in water.
Hydroxypropyl methylcellulose is a hydrocolloid produced artificially from natural substances.
Hydroxypropyl methylcellulose consists of 28-30% methoxyl content and 7-12% of hydroxypropoxyl content.
Hydroxypropyl methylcellulose belongs to the group of cellulose ethers in which hydroxyl groups have been substituted with one or more of the three hydroxyl groups present in the cellulose ring.
Hydroxypropyl methylcellulose is hydrophilic (water soluble), a biodegradable, and biocompatible polymer having a wide range of applications in drug delivery, dyes and paints, cosmetics, adhesives, coatings, agriculture, and textiles.
Hydroxypropyl methylcellulose is also soluble in polar organic solvents, making Hydroxypropyl methylcellulose possible to use both aqueous and nonaqueous solvents.
Hydroxypropyl methylcellulose has unique solubility properties with solubility in both hot and cold organic solvents.
Hydroxypropyl methylcellulose possesses increased organo-solubility and thermo-plasticity compared to other methyl cellulose counterparts.
Hydroxypropyl methylcellulose forms gel upon heating with gelation temperature of 75–90oC.
By reducing the molar substitution of hydroxyl propyl group, the glass transition temperature of Hydroxypropyl methylcellulose can be reduced to 40oC.
Hydroxypropyl methylcellulose forms flexible and transparent films from aqueous solution.
Hydroxypropyl methylcellulose films are generally odorless and tasteless, and can be effectively used in reducing absorption of oil from fried products such as French fries because of their resistance to oil migration.
Hydroxypropyl methylcellulose is extensively used in the food industry as a stabilizer, as an emulsifier, as a protective colloid, and as a thickener.
Hydroxypropyl methylcellulose is used as a raw material for coatings with moderate strength, moderate moisture and oxygen barrier properties, elasticity, transparency, and resistance to oil and fat.
Hydroxypropyl methylcellulose is also used as a tablet binder and as a tablet matrix for extended release.
The potential application of Hydroxypropyl methylcellulose in biomedical field has attracted great attention of both scientists and academicians because of Hydroxypropyl methylcellulose excellent biocompatibility and low toxicity.
Biopolymer composites are very promising materials because they are easy to process, eco-friendly in nature, and offer better properties.
Hydroxypropyl methylcellulose, being a biodegradable polymer, has also been used to prepare biocomposites.
Hydroxypropylmethylcellulose is also known by the abbreviation “HPMC”.
Hydroxypropyl methylcellulose is produced from cellulose.
Hydroxypropyl methylcellulose is an auxiliary polymer substance used to stabilize emulsions as well as to thicken the formulations in which Hydroxypropyl methylcellulose is used.
Hydroxypropyl methylcellulose can stabilize foam when used in cleaning products.
Hydroxypropyl methylcellulose provides care by preventing frizz in hair care products and also by creating a film layer that protects the hair strands.
Hydroxypropyl methylcellulose is an auxiliary substance in stabilizing emulsions and ensuring their fluidity in cosmetic product formulations.
Uses Hydroxypropyl methylcellulose:
Hydroxypropyl methylcellulose are water soluble polymers derived from cellulose.
Hydroxypropyl methylcellulose is typically used as thickeners, binders, film formers, and water retention agents.
Hydroxypropyl methylcellulose is also function as suspension aids, surfactants, lubricants, protective colloids, and emulsifiers.
In addition, solutions of these polymers thermally gel.
Hydroxypropyl methylcellulose has many excellent properties.
Hydroxypropyl methylcellulose is a gum formed by the reaction of propylene oxide and methyl chloride with alkali cellulose.
Hydroxypropyl methylcellulose will gel as the temperature is increased in heating and upon cooling will liquefy.
Hydroxypropyl methylcellulose temperature ranges from 60°c to 90°c, forming semifirm to mushy gels.
Hydroxypropyl methylcellulose is used in bakery goods, dressings, breaded foods, and salad dressing mix for syneresis control, texture, and to provide hot viscosity.
Hydroxypropyl methylcellulose is usage level ranges from 0.05 to 1.0%.
Hydroxypropyl methylcellulose is used as an ophthalmic lubricant, an emulsifier and a thickening and suspending agent.
Hydroxypropyl methylcellulose is widely used as an excipient in pharmaceutical formulations.
Hydroxypropyl methylcellulose acts as a food additive.
Hydroxypropyl methylcellulose’s eye drops are known as artificial tears, which are used to relieve eye dryness and soreness.
Hydroxypropyl methylcellulose finds applications in various fields as emulsifier, film former, protective colloid, stabilizer, suspending agent, or thickener in foods.
Hydroxypropyl methylcellulose is pharmaceutic aid (suspending agent; tablet excipient; demulcent; viscosity increasing agent); hydrophilic carrier in drug delivery systems.
Hydroxypropyl methylcellulose is used in adhesives, asphalt emulsions, caulking compounds, tile mortars, plastic mixes, cements, paints.
Hydroxypropyl methylcellulose is presented below some examples of Hydroxypropyl methylcellulose applications:
Food industry:
Hydroxypropyl methylcellulose is stabilizers of emulsions and foams, as a replacement for fat, as a non-caloric bulking agentin foods, as a binder, among others.
Pharmaceutical industry:
Hydroxypropyl methylcellulose is used as a dispersing and thickening agent, film-coating of tablets, drug preparations,among others.
Cosmetics industry:
Hydroxypropyl methylcellulose is used in hair shampoo, eye makeup, skin care preparations, among others.
Indications:
Hydroxypropyl methylcellulose belongs to the group of medicines known as artificial tears.
Hydroxypropyl methylcellulose is used to relieve dryness and irritation caused by reduced tear flow.
Hydroxypropyl methylcellulose helps prevent damage to the eye in certain eye diseases.
Hydroxypropyl methylcellulose may also be used to moisten hard contact lenses and artificial eyes.
In addition, Hydroxypropyl methylcellulose may be used in certain eye examinations.
Use in whole grain breads:
Agricultural Research Service scientists are investigating using the plant-derived Hydroxypropyl methylcellulose as a substitute for gluten in making all-oat and other grain breads.
Gluten, which is present in wheat, rye, and barley, is absent (or present only in trace quantities) in oat and other grains.
Like gluten, Hydroxypropyl methylcellulose can trap air bubbles formed by the yeast in bread dough, causing the bread to rise.
Use in construction materials:
Hydroxypropyl methylcellulose is used primarily in construction materials like tile adhesives and renders where Hydroxypropyl methylcellulose is used as a rheology modifier and water retention agent.
Functionally Hydroxypropyl methylcellulose is very similar to HEMC (hydroxy ethyl methyl cellulose).
Applications Hydroxypropyl methylcellulose:
Hydroxypropyl methylcellulose has been used:
Hydroxypropyl methylcellulose is used as a viscosity modifier in the preparation of printable ink
Hydroxypropyl methylcellulose is used as a viscosifier in the preparation of hydroxyapatite (HAP) suspension
Hydroxypropyl methylcellulose is used in the preparation of Hydroxypropyl methylcellulose gels and composite gels
Hydroxypropyl methylcellulose is thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.
Ophthalmic applications:
Hydroxypropyl methylcellulose solutions were patented as a semisynthetic substitute for tear-film.
Hydroxypropyl methylcellulose’s molecular structure is predicated upon a base celluloid compound that is highly water-soluble.
Post-application, celluloid attributes of good water solubility reportedly aid in visual clarity.
When applied, a Hydroxypropyl methylcellulose solution acts to swell and absorb water, thereby expanding the thickness of the tear-film.
Hydroxypropyl methylcellulose augmentation therefore results in extended lubricant time presence on the cornea, which theoretically results in decreased eye irritation, especially in dry climates, home, or work environments.
On a molecular level, this polymer contains beta-linked D-glucose units that remain metabolically intact for days to weeks.
On a manufacturing note, since hypromellose is a vegetarian substitute for gelatin, Hydroxypropyl methylcellulose is slightly more expensive to produce due to semisynthetic manufacturing processes.
Aside from Hydroxypropyl methylcellulose’s widespread commercial and retail availability over the counter in a variety of products, hypromellose 2% solution has been documented to be used during surgery to aid in corneal protection and during orbital surgery.
Excipient/tableting ingredient:
In addition to Hydroxypropyl methylcellulose use in ophthalmic liquids, hypromellose has been used as an excipient in oral tablet and capsule formulations, where, depending on the grade, Hydroxypropyl methylcellulose functions as controlled release agent to delay the release of a medicinal compound into the digestive tract.
Hydroxypropyl methylcellulose is also used as a binder and as a component of tablet coatings.
Liquid Detergents:
Hydroxypropyl methylcellulose and methyl cellulose are also water-soluble nonionic polymers.
They are compatible with inorganic salts and ionic species up to a certain concentration.
Hydroxypropyl methylcellulose can be salted out of solution when the concentration of electrolytes or other dissolved materials exceeds certain limits.
Hydroxypropyl methylcellulose has a higher tolerance for salts in solution than methyl cellulose.
Both are stable over a pH range of 3 to 11.
Commercial water-soluble methyl cellulose products have a methoxy DS of 1.64 to 1.92.
A DS of lower than 1.64 yields material with lower water solubility.
The methoxy DS in hydroxypropyl methyl cellulose ranges from 1.3 to 2.
The hydroxypropyl MS ranges from 0.13 to 0.82.
Methyl cellulose and Hydroxypropyl methylcellulose polymers have a number of applications and are used as thickeners in latex paints, food products, shampoos, creams and lotions, and cleansing gels.
U.S.Patent 5,565,421 is an example of the use of Hydroxypropyl methylcellulose polymer to gel a light-duty liquid detergent containing anionic surfactants.
Features Hydroxypropyl methylcellulose:
Hydroxypropyl methylcellulose is propylene glycol ether of methyl cellulose, hydroxypropyl and methyl combine with anhydrous glucose ring by ether bond.
Hydroxypropyl methylcellulose is white or pale white cellulose powder or particles.
The characteristics of cold water dissolution and hot water insoluble are similar with methyl cellulose.
Hydroxypropyl methylcellulose is solubility in organic solvents is superior than water soluble, can be dissolved in anhydrous methanol and ethanol solution, also soluble in chlorinated hydrocarbons and ketones in organic solvents.
Hydroxypropyl methylcellulose is soluble in water, its water solution has a surface activity, the formation of the film after drying, heated and cooled, in turn, from the reversible conversion of sol to gel.
Hydroxypropyl methylcellulose can be used alone in the cold drink, also can be used with other emulsifier, stabilizer.
To cold drink, the maximum amount is 1%.
Hydroxypropyl methylcellulose and other water-soluble high weight compounds use mixture, become transparent, higher viscosity.
The gelation temperature of low viscosity products is higher than high viscosity of products.
Hydroxypropyl methylcellulose’s solution is stable at room temperature.
Hydroxypropyl methylcellulose has been widely used in petroleum chemical industry, papermaking, leather, textile printing and dyeing, pharmaceutical, food, cosmetics and other industries, and as the dispersing agent, thickening agent, adhesive, excipient, capsule, oil resistant coating and packing etc.
Features and Benefits Hydroxypropyl methylcellulose:
Hydroxypropyl methylcellulose is dissolves in water, undergoes reversible gelation upon heating, non-ionic, does not complex with ionic species and is surface active and enzyme resistant.
Hydroxypropyl methylcellulose is solutions are pseudoplastic.
Chemistry Hydroxypropyl methylcellulose:
Hydroxypropyl methylcellulose is a solid, and is a slightly off-white to beige powder in appearance and may be formed into granules.
The compound forms colloids when dissolved in water.
This non-toxic Hydroxypropyl methylcellulose is combustible and can react vigorously with oxidizing agents.
Hydroxypropyl methylcellulose in an aqueous solution, like methylcellulose, exhibits a thermal gelation property.
That is, when the solution heats up to a critical temperature, the solution congeals into a non-flowable but semi-flexible mass.
Typically, this critical (congealing) temperature is inversely related to both the solution concentration of Hydroxypropyl methylcellulose and the concentration of the methoxy group within the Hydroxypropyl methylcellulose molecule (which in turn depends on both the degree of substitution of the methoxy group and the molar substitution).
That is, the higher the concentration of the methoxy group, the lower the critical temperature.
The inflexibility/viscosity of the resulting mass, however, is directly related to the concentration of the methoxy group (the higher the concentration is, the more viscous or less flexible the resulting mass is).
Production Methods Hydroxypropyl methylcellulose:
A purified form of cellulose, obtained from cotton linters or wood pulp, is reacted with sodium hydroxide solution to produce a swollen alkali cellulose that is chemically more reactive than untreated cellulose.
The alkali cellulose is then treated with chloromethane and propylene oxide to produce methyl hydroxypropyl ethers of cellulose.
The fibrous reaction product is then purified and ground to a fine, uniform powder or granules.
Hydroxypropyl methylcellulose can then be exposed to anhydrous hydrogen chloride to induce depolymerization, thus producing low viscosity grades.
Hydroxypropyl methylcellulose is obtained by treatment of fibrous plant material with alkali, methyl chloride and propylene oxide.
1.The refined cotton cellulose with alkali treatment at 35-40 ℃ for half an hour, press, crushed the cellulose, aging at 35 ℃, so that the average degree of polymerization of alkali cellulose is in a desired range.
The alkali fiber into etherification reactor, followed by adding epoxy propane and methane chloride, etherification at 50-80 ℃ for 5h, the maximum pressure is about 1.8MPa.
The reaction products were produced by postprocessing (hydrochloric acid and oxalic acid, washing and drying).
The consumption of raw material of cotton pulp 1100kg/t, methyl chloride and propylene oxide 4300kg/t, solid alkali 1200kg/t, hydrochloride 30kg/t, oxalic acid 50kg/t.
2.100 kg refined cotton linters immersed in 45% solution, temperature is 35 to 40℃, time is 0.5 to 1 h, and then remove the press.
The pressure to weight is 2.7 times as the weight of lint, stop pressure.
Carry out the crushing.
At 35℃, aging for 16h.
In the reaction kettle, the chlorinated methane, propylene oxide were added into the reaction kettle.
At 80℃, the pressure was 1.8 MPa, the reaction time is 5 to 8 h, and the amount of hydrochloric acid and oxalic acid were added to the hot water at 90℃.
Dewatering with centrifuge, washing to neutral, when the water content of the material is below to 60% , 130℃ of hot air flow dried to the moisture content is below 5%.
Finally, the finished product sieved by 20 mesh.
3. Prepared by cellulose, methyl chloride, and ethylene oxide.
Test methods Hydroxypropyl methylcellulose:
Various benchmark tests are used to qualify Hydroxypropyl methylcellulose:
Viscosity
Degree of substitution (DS)
Molar substitution (MS)
Salt content
Moisture
Viscosity test methods:
Because Hydroxypropyl methylcellulose solution is a non-newtonian solution and exhibits pseudoplastic, more specifically, thixotropic behavior, various test methods are available, and the results of different methods and viscosimeters do not necessarily correspond to each other.
Also, due to viscometer acceptable ranges of error, viscosity is typically given as a mean, or as a range.
Typical viscosity test will specify the following:
Solution concentration (1%, 2%, 1.9% bone dry, etc.)
Viscometer (RheoSense m-VROC and microVISC, Brookfield LV or RV, Höppler falling ball, Haake Rotovisco, etc.)
Viscometer spindle number (1 ~ 4 for Brookfield LV, 1 ~ 7 for Brookfield RV, etc.)
Solution Temperature (20 °C, 25 °C, etc.)
Degree of substitution:
Degree of substitution is the average level of methoxy substitution on the cellulose chain.
Since there are maximum three possible sites of substitution with each cellulose molecule, this average value is a real number between 0 and 3.
However, degree of substitution is often expressed in percentages.
Molar substitution:
Molar substitution is the average level of hydroxypropoxy substitution on the cellulose chain.
Since hydroxypropoxy base can be attached to each other on side chains and does not each require a base substitution site on the cellulose molecule, this number can be higher than 3.
However, molar substitution is also often expressed in percentages.
Moisture:
Since all cellulose ethers are hygroscopic, they will absorb moisture from surroundings if left exposed from original packaging.
Thus, moisture must be tested and weight corrected to ensure adequate amount of dry active material are apportioned for usage.
Moisture is tested by weighing a sample of X grams on an analytic scale, and drying the sample in an oven at 105 °C for 2 hours, then weighing the sample again on the same scale.
Biochem/physiol Actions Hydroxypropyl methylcellulose:
Hydroxypropyl methylcellulose act as suspension aids, surfactants, lubricants, protective colloids, and emulsifiers.
Additionally, solutions of these polymers show thermal gelation properties.
They are generally used as binders, thickeners, film formers, and water retention agents.
Hydroxypropyl methylcellulose also elicits surface-active properties.
Handling and Storage Hydroxypropyl methylcellulose:
Precautions for safe handling:
Advice on protection against fire and explosion:
Provide appropriate exhaust ventilation at places where dust is formed.
Hygiene measures:
General industrial hygiene practice.
Conditions for safe storage, including any incompatibilities:
Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Keep in a dry place.
Storage class:
Storage class (TRGS 510): 13: Non Combustible Solids
Stability and Reactivity Hydroxypropyl methylcellulose:
Reactivity:
No data available
Chemical stability:
Stable under recommended storage conditions.
Possibility of hazardous reactions:
No data available
Conditions to avoid:
No data available
Incompatible materials:
Strong oxidizing agents, Cellulose and its derivatives may react vigorously with:, bleaching powder, Fluorine, Nitric acid
Health Effect Hydroxypropyl methylcellulose:
Hydroxypropyl methylcellulose is a semi-synthetic component.
The starting raw materials are of natural origin, but are transformed into a different form than their initial state using various processes under laboratory conditions.
These are raw materials obtained without using animal sources (propolis, honey, beeswax, lanolin, collagen, snail extract, milk, etc.).
Hydroxypropyl methylcellulose is a criterion that should be taken into consideration for those who want to use vegan products.
Studies have concluded that different effects can be seen on each skin type.
For this reason, the allergy/irritation effect may vary from person to person.
However, Hydroxypropyl methylcellulose may cause reactions such as stinging, tingling, itching, redness, irritation, skin flaking and swelling, especially in people with sensitive skin types.
Consult your dermatologist before using a product containing this ingredient.
No literature information regarding Hydroxypropyl methylcellulose carcinogenic effect could be found.
No literature information regarding reproductive/endocrine/organ effects could be found.
According to TITCK and/or EU Cosmetics Regulation, there is no restriction on the use of this raw material in cosmetic products.
For the safe use of this raw material, manufacturers need to develop product formulations taking user safety into consideration.
First Aid Measures Hydroxypropyl methylcellulose:
If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
In case of skin contact:
Wash off with soap and plenty of water.
In case of eye contact:
Flush eyes with water as a precaution.
If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Indication of any immediate medical attention and special treatment needed:
No data available
Firefighting Measures Hydroxypropyl methylcellulose:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture:
Nature of decomposition products not known.
Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Further information:
No data available
Accidental Release Measures Hydroxypropyl methylcellulose:
Personal precautions, protective equipment and emergency procedures:
Avoid dust formation.
Avoid breathing vapors, mist or gas.
Environmental precautions:
No special environmental precautions required.
Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.
Identifiers Hydroxypropyl methylcellulose:
CAS Number: 9004-65-3
ChemSpider: 21241863
ECHA InfoCard: 100.115.379
EC Number: 618-389-6
E number: E464 (thickeners, …)
UNII: 36SFW2JZ0W
CompTox Dashboard (EPA): DTXSID7037054
InChI: InChI=1S/C36H70O19.C20H38O11/c1-19(37)9-45-17-27-29(47-11-21(3)39)31(48-12-22(4)40)34(51-15-25(7)43)36(54-27)55-30-28(18-46-10-20(2)38)53-35(52-16-26(8)44)33(50-14-24(6)42)32(30)49-13-23(5)41;1-21-9-11-13(23-3)15(24-4)18(27-7)20(30-11)31-14-12(10-22-2)29-19(28-8)17(26-6)16(14)25-5/h19-44H,9-18H2,1-8H3;11-20H,9-10H2,1-8H3/t19?,20?,21?,22?,23?,24?,25?,26?,27-,28-,29-,30-,31+,32+,33-,34-,35-,36+;11-,12-,13-,14-,15+,16+,17-,18-,19-,20+/m11/s1
Key: PUSNGFYSTWMJSK-GSZQVNRLSA-N
InChI=1/C36H70O19.C20H38O11/c1-19(37)9-45-17-27-29(47-11-21(3)39)31(48-12-22(4)40)34(51-15-25(7)43)36(54-27)55-30-28(18-46-10-20(2)38)53-35(52-16-26(8)44)33(50-14-24(6)42)32(30)49-13-23(5)41;1-21-9-11-13(23-3)15(24-4)18(27-7)20(30-11)31-14-12(10-22-2)29-19(28-8)17(26-6)16(14)25-5/h19-44H,9-18H2,1-8H3;11-20H,9-10H2,1-8H3/t19?,20?,21?,22?,23?,24?,25?,26?,27-,28-,29-,30-,31+,32+,33-,34-,35-,36+;11-,12-,13-,14-,15+,16+,17-,18-,19-,20+/m11/s1
Key: PUSNGFYSTWMJSK-GSZQVNRLBE
Properties Hydroxypropyl methylcellulose:
Melting point: 225-230 °C
Density: 1.39
Storage temp.: room temp
Solubility: H2O: 50 mg/mL, clear to very faintly turbid, faintly yellow
Form: powder
Color: White to cream
Odor: Odorless
Water Solubility: SOLUBLE
Merck: 14,4842
Stability: Stable. Solid is combustible, incompatible with strong oxidizing agents.
EPA Substance Registry System: Hydroxypropyl methylcellulose (9004-65-3)
Appearance: White and off-white powder
Methyl content (%): 19.0~ 24.0
Hydroxypropoxy (%): 4.0 ~ 12.0
pH: 4.0~ 8.0
Moisture content(%): ≤ 5.0
Ash residue (%): ≤ 5.0
Piece size: min.99% — 100
Viscosity brookfield 2% solution: 55 000- 85 000 m pass
Viscosity NDJ 2% solution: 120 000-200 000 m rust
Dissolution: in cold water
biological source: plant
Quality Level: 200
form: powder
mol wt: ~86 kDa
color: white to off-white
viscosity: 2,600-5,600 cP, 2 % in H2O(20 °C)(lit.)
solubility: water: 10 mg/mL, clear to very slightly hazy, colorless
storage temp.: room temp
Names of Hydroxypropyl methylcellulose:
Other names:
Hydroxypropyl methylcellulose
hydroxypropyl methyl cellulose
HPMC
E464