ISOBORNYL ACETATE (ZOBORNL ASETAT)

CAS No. : 125-12-2

EC No. : 204-727-6

Synonyms:

Acetic acid isobornyl ester; exo-(1R)-1,7,7-Trimethylbicyclo[2.2.1]hept-2-yl acetate; DL-isobornyl acetate; [(1R,4S,6R)-1,7,7-trimethyl-6-bicyclo[2.2.1]heptanyl] acetate; Isobornyl acetate; Pichtosin; 125-12-2; Pichtosine; Isoborneol, acetate; Acetic acid, isobornyl ester; acetic acid isobornyl ester; exo-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl acetate; Isobornyl Acetate,(S); KSC514E5B; SCHEMBL1133020; CTK4B4250; NSC62486; (1S,4R)-Bornane-2beta-ol acetate; Pichtosine; 1,7,7-trimethyl-,acetate,exo-bicyclo(2.2.1)heptan-2-o; 1,7,7-trimethyl-,acetate,exo-bicyclo[2.2.1]heptan-2-o; 1,7,7-trimethyl-,acetate,exo-Bicyclo[2.2.1]heptan-2-ol; zobornil asetat (isobornyl acetate); 1,7,7-Trimethylbicyclo[2.2.1]hept-2-yl acetate; Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, acetate, exo-; Bicyclo[2.2.1]heptan-2-ol,1,7,7-trimethyl-,acetate,(1R,2R,4R)-rel-; Bicyclo[2.2.1]heptan-2-ol,1,7,7-trimethyl-,acetate,exo-; exo-Bornyl acetate; Pichtosin; [(1R,3S,4S)-4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl] acetate; ANW-41566; NSC-62486; AKOS015904128; ZINC100028042; FT-0627337; Bicyclo[2.2.1]heptan-2-ol,7,7-trimethyl-, acetate, exo-; (1S,2S,4S)-1,7,7-TRIMETHYLBICYCLO[2.2.1]HEPTAN-2-YL ACETATE; Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, acetate, exo-; 2-Hydroxypropane; i-PrOH; Dimethyl carbinol; IPA; 2-Propanol; isopropanol; Isopropyl alcohol; Propan-2-ol; zobornil asetat (isobornyl acetate); 67-63-0; 2-Hydroxypropane; Alkolave; Avantine; Hartosol; Dimethylcarbinol; Isoborneol, acetate; Acetic acid, isobornyl ester; Pichtosin; Pichtosine; Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl-, 2-acetate, (1R,2R,4R)-rel-; exo-Bornyl acetate; 2-Bornyl acetate, exo-; exo-1,7,7-Trimethylbicyclo(2.2.1)hept-2-yl acetate; 1,7,7-Trimethylbicyclo[2.2.1]hept-2-yl acetate; 17283-45-3; endo-Bornyl acetate; zobornil asetat (isobornyl acetate); (+)-Bornyl acetate = Isobornyl acetate; 2-BORNANOL:ACETATE, EXO; 2-CAMPHANYL ACETATE; ACETIC ACID ISOBORNYL ESTER; BORNYL ACETATE (ISO); D,L-ISOBORNYL ACETATE; exo-1,7,7-Trimethylbicyclo[2.2.1]hept-2-yl acetate; EXO-(1R)-1,7,7-TRIMETHYLBICYCLO[2.2.1]HEPT-2-YL ACETATE; Acetic acid isobornyl ester; exo-(1R)-1,7,7-Trimethylbicyclo[2.2.1]hept-2-yl acetate; DL-isobornyl acetate; [(1R,4S,6R)-1,7,7-trimethyl-6-bicyclo[2.2.1]heptanyl] acetate; Isobornyl acetate; Pichtosin; 125-12-2; Pichtosine; Isoborneol, acetate; Acetic acid, isobornyl ester; acetic acid isobornyl ester; exo-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl acetate; Isobornyl Acetate,(S); KSC514E5B; zobornil asetat (isobornyl acetate); SCHEMBL1133020; CTK4B4250; NSC62486; (1S,4R)-Bornane-2beta-ol acetate; [(1R,3S,4S)-4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl] acetate; ANW-41566; NSC-62486; AKOS015904128; ZINC100028042; FT-0627337; Bicyclo[2.2.1]heptan-2-ol,7,7-trimethyl-, acetate, exo-; (1S,2S,4S)-1,7,7-TRIMETHYLBICYCLO[2.2.1]HEPTAN-2-YL ACETATE; Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, acetate, exo-; Isoborneol, acetate; FEMA 2160; ISO-BORNEOL ACETATE; ISOBORNYL ACETATE; Pichtosine; 1,7,7-trimethyl-,acetate,exo-bicyclo(2.2.1)heptan-2-o; 1,7,7-trimethyl-,acetate,exo-bicyclo[2.2.1]heptan-2-o; 1,7,7-trimethyl-,acetate,exo-Bicyclo[2.2.1]heptan-2-ol; 1,7,7-Trimethylbicyclo[2.2.1]hept-2-yl acetate; Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, acetate, exo-; Bicyclo[2.2.1]heptan-2-ol,1,7,7-trimethyl-,acetate,(1R,2R,4R)-rel-; Bicyclo[2.2.1]heptan-2-ol,1,7,7-trimethyl-,acetate,exo-; exo-Bornyl acetate; Pichtosin; Acetic acid isobornyl ester; zobornil asetat (isobornyl acetate); exo-(1R)-1,7,7-Trimethylbicyclo[2.2.1]hept-2-yl acetate; DL-isobornyl acetate; [(1R,4S,6R)-1,7,7-trimethyl-6-bicyclo[2.2.1]heptanyl] acetate; Isobornyl acetate; Pichtosin; 125-12-2; Pichtosine; Isoborneol, acetate; Acetic acid, isobornyl ester; acetic acid isobornyl ester; exo-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl acetate; Isobornyl Acetate,(S); KSC514E5B; SCHEMBL1133020; CTK4B4250; NSC62486; (1S,4R)-Bornane-2beta-ol acetate; Pichtosine; 1,7,7-trimethyl-,acetate,exo-bicyclo(2.2.1)heptan-2-o; 1,7,7-trimethyl-,acetate,exo-bicyclo[2.2.1]heptan-2-o; 1,7,7-trimethyl-,acetate,exo-Bicyclo[2.2.1]heptan-2-ol; 1,7,7-Trimethylbicyclo[2.2.1]hept-2-yl acetate; Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, acetate, exo-

Isobornyl Acetate

Isobornyl acetate (izobornil asetat, isobornyl acetate) readily hydrolyzes (within hours) to isobornyl alcohol during the first step of its biochemical pathway. The alcohol will become conjugated with glucoronic acid and be excreted in the urine (expected within hours to days).

IDENTIFICATION: Isobornyl acetate (izobornil asetat, isobornyl acetate) is a colorless to straw-colored liquid. It has an odor like pine needles. It is not very soluble in water. Isobornyl acetate (izobornil asetat, isobornyl acetate) is a natural component in many plants. USE: Isobornyl acetate (izobornil asetat, isobornyl acetate) is an important commercial chemical. It is used in perfuming soaps, air fresheners and in making camphor. It is also used as a flavoring ingredient. EXPOSURE: Workers that use Isobornyl acetate (izobornil asetat, isobornyl acetate) may breathe in vapors or have direct skin contact. The general population may be exposed by vapors, dermal contact and consumption of food flavored with Isobornyl acetate (izobornil asetat, isobornyl acetate). If Isobornyl acetate (izobornil asetat, isobornyl acetate) is released to the environment, it will be broken down in air. It is not expected to be broken down by sunlight. It will move into air from moist soil and water surfaces. It is expected to move through soil. It will be broken down by microorganisms, and is expected to build up in fish. RISK: Allergic skin reactions were not observed in volunteers following direct skin exposure. Other data on the potential for Isobornyl acetate (izobornil asetat, isobornyl acetate) to produce toxic effects in humans were not available. Isobornyl acetate (izobornil asetat, isobornyl acetate) is a mild skin irritant in laboratory animals. Kidney and liver damage and changes in kidney function were reported in laboratory animals following repeated exposure to moderate-to-high oral doses of Isobornyl acetate (izobornil asetat, isobornyl acetate) over time. No effects were reported at low doses. No evidence of infertility, abortion, or birth defects was reported in laboratory animals exposed to high oral doses of Isobornyl acetate (izobornil asetat, isobornyl acetate) before and during pregancy. Data on the potential for Isobornyl acetate (izobornil asetat, isobornyl acetate) to cause cancer in laboratory animals were not available. The potential for Isobornyl acetate (izobornil asetat, isobornyl acetate) to cause cancer in humans has not been assessed by the U.S. EPA IRIS program, the International Agency for Research on Cancer, or the U.S. National Toxicology Program 14th Report on Carcinogens.

For Isobornyl acetate (izobornil asetat, isobornyl acetate) (USEPA/OPP Pesticide Code: 128875) there are 0 labels match. /SRP: Not registered for current use in the USA, but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses.

Isobornyl acetate (izobornil asetat, isobornyl acetate) is used in large amounts for perfuming soap, bath products, and air fresheners. However, the major use of Isobornyl acetate (izobornil asetat, isobornyl acetate) is as an intermediate in the production of camphor.

Isobornyl acetate (izobornil asetat, isobornyl acetate) is prepared from camphene and acetic acid in the presence of acidic catalysts (e.g., sulfuric acid), or on a styrene-divinylbenzene acid ion-exchanger.

Residues of Isobornyl acetate (izobornil asetat, isobornyl acetate) are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only.

IDENTIFICATION AND USE: Isobornyl acetate (izobornil asetat, isobornyl acetate) is used in soaps, detergents, creams and lotions and perfumes. HUMAN STUDIES: A maximization test was carried out on 25 volunteers. The material was tested at a concentration of 10% and produced no sensitization reactions. ANIMAL STUDIES: Isobornyl acetate (izobornil asetat, isobornyl acetate) applied full strength to intact or abraded rabbit skin for 24 hr under occlusion was mildly irritating. Isobornyl acetate (izobornil asetat, isobornyl acetate) was administered daily to rats in doses of 0, 15, 90 or 270 mg/kg bw for 13 wk. Male rats had signs of nephrotoxicity at 90 mg/kg and 270 mg/kg/day, as well as signs of hepatotoxicity at 270 mg/kg. Isobornyl acetate (izobornil asetat, isobornyl acetate) was investigated in a 1-generation reproduction study in rats and it did not produce developmental toxicity. Increased incidences of excess salivation occurred in parent generation male and female rats at 100 and/or 300 mg/kg/d throughout the dosage period, and low incidences of urine-stained abdominal fur were seen in females at 300 mg/kg/d during the gestation period.

Isobornyl acetate (izobornil asetat, isobornyl acetate)’s production and use in toilet waters, bath preparations, antiseptics, soaps, making synthetic camphor and as a flavoring agent may result in its release to the environment through various waste streams. Its use in compounding needle odors and theater sprays will result in its direct release to the environment. Isobornyl acetate (izobornil asetat, isobornyl acetate) is reported in a wide variety of herbs and other plants. If released to air, an estimated vapor pressure of 0.11 mm Hg at 25 °C indicates Isobornyl acetate (izobornil asetat, isobornyl acetate) will exist solely as a vapor in the atmosphere. Vapor-phase Isobornyl acetate (izobornil asetat, isobornyl acetate) will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 50 hrs. Isobornyl acetate (izobornil asetat, isobornyl acetate) does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, Isobornyl acetate (izobornil asetat, isobornyl acetate) is expected to have moderate mobility based upon an estimated Koc of 420. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry’s Law constant of 9.5X10-5 atm-cu m/mole. Isobornyl acetate (izobornil asetat, isobornyl acetate) has an estimated vapor pressure of 0.11 mm Hg and exists as a liquid under environmental conditions; therefore, Isobornyl acetate (izobornil asetat, isobornyl acetate) may volatilize from dry soil. Using the OECD Biodegradability test, isoborneol acetate was biodegraded in 10 days, suggesting that biodegradation is an important environment fate process in soil or water. If released into water, Isobornyl acetate (izobornil asetat, isobornyl acetate) is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound’s estimated Henry’s Law constant. Estimated volatilization half-lives for a model river and model lake are 17 hrs and 9.5 days, respectively. An estimated BCF of 320 suggests the potential for bioconcentration in aquatic organisms is moderate. Hydrolysis is not expected to be an important environmental fate process as indicated by estimated base-catalyzed second-order half-lives of 2.3 yrs and 84 days at pH values of 7 and 8, respectively. Occupational exposure to Isobornyl acetate (izobornil asetat, isobornyl acetate) may occur through inhalation and dermal contact with this compound at workplaces where Isobornyl acetate (izobornil asetat, isobornyl acetate) is produced or used. Monitoring data indicate that the general population may be exposed to Isobornyl acetate (izobornil asetat, isobornyl acetate) via inhalation of ambient air, ingestion of food, and dermal contact with consumer products containing Isobornyl acetate (izobornil asetat, isobornyl acetate).

Isobornyl acetate (izobornil asetat, isobornyl acetate) is reported in a wide variety of herbs and other plants(1). It is a natural emmission from pine and fir trees(2). The compound is reported as occurring in thymus, Parmesan cheese, dill herb, Ocimum basilicum, rosemary and custard apple(3).

Isobornyl acetate (izobornil asetat, isobornyl acetate)’s production and use in toilet waters, bath preparations, antiseptics, soaps, making synthetic camphor(1) and as a flavoring agent(1,2) may result in its release to the environment through various waste streams. Its use in compounding pine needle odors and theater sprays(1) will result in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 420(SRC), determined from a structure estimation method(2), indicates that Isobornyl acetate (izobornil asetat, isobornyl acetate) is expected to have moderate mobility in soil(SRC). Volatilization of Isobornyl acetate (izobornil asetat, isobornyl acetate) from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry’s Law constant of 9.5X10-5 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). Isobornyl acetate (izobornil asetat, isobornyl acetate) has an estimated vapor pressure of 0.11 mm Hg(2) and exists as a liquid under environmental conditions; therefore, Isobornyl acetate (izobornil asetat, isobornyl acetate) may volatilize from dry soil. Using the OECD Biodegradability test, isoborneol acetate was biodegraded in 10 days(3), suggesting that biodegradation is an important environment fate process in soil(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), Isobornyl acetate (izobornil asetat, isobornyl acetate), which has an estimated vapor pressure of 0.11 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase Isobornyl acetate (izobornil asetat, isobornyl acetate) is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 50 hrs(SRC), calculated from its rate constant of 7.7X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Isobornyl acetate (izobornil asetat, isobornyl acetate) does not contain chromophores that absorb at wavelengths >290 nm(3) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: Isobornyl acetate (izobornil asetat, isobornyl acetate) was biodegraded in 10 days in the OECD Ready Biodegradability test. The compound was 29.0 and 99.8% removed in wastewater treat plants under primary gravitational settling and activated sludge treatement process, respectively(1).

The rate constant for the vapor-phase reaction of Isobornyl acetate (izobornil asetat, isobornyl acetate) with photochemically-produced hydroxyl radicals has been estimated as 7.7X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 50 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 9.5X10-2 L/mole-sec(SRC) was estimated using a structure estimation method(1); this corresponds to half-lives of 2.3 yrs and 84 days at pH values of 7 and 8, respectively(1). Isobornyl acetate (izobornil asetat, isobornyl acetate) does not contain chromophores that absorb at wavelengths >290 nm(2) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 320 was calculated in fish for Isobornyl acetate (izobornil asetat, isobornyl acetate)(SRC), using a log Kow of 4.30(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of Isobornyl acetate (izobornil asetat, isobornyl acetate) can be estimated to be 420(SRC). According to a classification scheme(2), this estimated Koc value suggests that Isobornyl acetate (izobornil asetat, isobornyl acetate) is expected to moderate mobility in soil(SRC).

The Henry’s Law constant for Isobornyl acetate (izobornil asetat, isobornyl acetate) is estimated as 9.5X10-5 atm-cu m/mole(SRC) developed using a fragment constant estimation method(1). This Henry’s Law constant indicates that Isobornyl acetate (izobornil asetat, isobornyl acetate) is expected to volatilize from water surfaces(2). Based on this Henry’s Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 17 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 9.5 days(SRC). Isobornyl acetate (izobornil asetat, isobornyl acetate)’s Henry’s Law constant indicates that volatilization from moist soil surfaces may occur(SRC).Isobornyl acetate (izobornil asetat, isobornyl acetate) has an estimated vapor pressure of 0.11 mm Hg(SRC), determined from a fragment constant method(13) and exists as a liquid under environmental conditions: therefore, Isobornyl acetate (izobornil asetat, isobornyl acetate) may volatilize from dry soil(SRC). Isobornyl acetate (izobornil asetat, isobornyl acetate) dissipated within one week when added along with 21 other fragrance materials to a Georgetown, DE anaerobically digested municipal sludge and applied to four soils (sandy agricultural loam, silty midwestern agrigultural loam, high organic carbon soil, and a highly weathered oxide-rich soil)(3).

Isobornyl acetate (izobornil asetat, isobornyl acetate) was reported at an average concentration of 5,130 ng/L in municipal wastewater influent and an average concentration of 24 ng/L in treated effluent, following a 3-day period in September 1997 at an activated sludge treatment plant in Loveland, OH. Influent and effluent average concentrations of 2,830 and 58 ng/L, respectively, when subjected to trickling filter wastewater treatment(1).

Isobornyl acetate (izobornil asetat, isobornyl acetate) was present in frankfurters in both 30% and 5% fat content samples analyzed(1). It was tested for but not detected in headspace volatiles from frankfurters(2).

Isobornyl acetate (izobornil asetat, isobornyl acetate) was detected not qunatified in emissions from pine-scented plug-in air fresheners(1).

Occupational exposure to Isobornyl acetate (izobornil asetat, isobornyl acetate) may occur through inhalation and dermal contact with this compound at workplaces where Isobornyl acetate (izobornil asetat, isobornyl acetate) is produced or used. Monitoring data indicate that the general population may be exposed to Isobornyl acetate (izobornil asetat, isobornyl acetate) via inhalation of ambient air, ingestion of food, and dermal contact with consumer products containing Isobornyl acetate (izobornil asetat, isobornyl acetate).

Isobornyl acetate (izobornil asetat, isobornyl acetate) is conifer herbal camphoraceous coniferous earthy pineneedle pine balsamic camphor aromatherapy lilac mens fougere needle woody lavender spruce citrus nutmeg ginger meat fruit-flavour.

Isobornyl acetate (izobornil asetat, isobornyl acetate) (an isomer of bornyl acetate) is a component of many essential oils, which was observed to be inhibitory to microorganisms. It was also shown to have sedative effect on mice after inhalation. Isobornyl acetate (izobornil asetat, isobornyl acetate) is mainly used in cosmetics as a flavor and fragrance agent.

Isobornyl acetate (izobornil asetat, isobornyl acetate) (IBCH, Sandenol) is an organic compound used primarily as a fragrance because of its aroma which is similar to sandalwood oil. Its chemical structure is closely related to that of both α-Santalol and β-Santalol,[3] which are the primary constituents of sandalwood oil.

Sandalwood trees are endangered due to overharvesting,[4] leading to a high cost for the natural oil. IBCH is therefore produced as an economical alternative to the natural product.

Applications of Isobornyl acetate (izobornil asetat, isobornyl acetate)

Isobornyl acetate (izobornil asetat, isobornyl acetate) is one of the most important chemicals used in the perfumery industry. It is used in toiletries and soaps as a flavoring agent and antiseptics. One of main applications is as an intermediate to produce camphor.

Solubility of Isobornyl acetate (izobornil asetat, isobornyl acetate)

Not miscible or difficult to mix with water.

Isobornyl acetate (izobornil asetat, isobornyl acetate) is a kind of acetate ester. It can be manufactured through the esterification between acetate and camphene. It is a kind of flavoring agent with fragrance. It can be used as the intermediate needed for producing medical synthetic camphor.

zobornil Asetat

zobornil asetat (isobornyl acetate), biyokimyasal yolunun ilk adm srasnda izobornil alkole kolayca hidrolize olur (saatler içinde). Alkol, glukoronik asit ile birleecek ve idrarla atlacaktr (saatler ila günler içinde beklenir).

TANIMLAMA: zobornil asetat (isobornyl acetate), renksiz ila saman rengi bir svdr. Çam inesi gibi bir kokusu vardr. Suda pek çözünür deildir. zobornil asetat (isobornyl acetate), birçok bitkide doal bir bileendir. KULLANIM: zobornil asetat (isobornyl acetate), önemli bir ticari kimyasaldr. Parfümlü sabunlarda, oda spreylerinde ve kafur yapmnda kullanlr. Ayn zamanda tatlandrc bir bileen olarak da kullanlr. MARUZ KALMA: zobornil asetat (isobornyl acetate) kullanan içiler buharlar soluyabilir veya dorudan ciltle temas edebilir. Genel popülasyon, buharlara, deri temasna ve izobornil asetat ile tatlandrlm yiyeceklerin tüketimine maruz kalabilir. zobornil asetat (isobornyl acetate) ortama salnrsa havada parçalanacaktr. Güne ndan parçalanmas beklenmez. Nemli toprak ve su yüzeylerinden havaya geçecektir. Toprakta hareket etmesi bekleniyor. Mikroorganizmalar tarafndan parçalanacak ve balklarda birikmesi bekleniyor. RSK: Dorudan cilt maruziyetini takiben gönüllülerde alerjik cilt reaksiyonlar gözlenmedi. zobornil asetat (isobornyl acetate)n insanlarda toksik etkiler üretme potansiyeline ilikin baka veriler mevcut deildi. zobornil asetat (isobornyl acetate), laboratuar hayvanlarnda hafif bir cilt tahri edicidir. Böbrek ve karacier hasar ve böbrek fonksiyonunda deiiklikler, zaman içinde orta ila yüksek oral izobornil asetat dozlarna tekrar tekrar maruz kaldktan sonra laboratuvar hayvanlarnda bildirilmitir. Düük dozlarda hiçbir etki bildirilmemitir. Gebelik öncesinde ve srasnda yüksek oral dozlarda izobornil asetata maruz kalan laboratuvar hayvanlarnda ksrlk, düük veya doum kusurlarna dair hiçbir kant bildirilmemitir. zobornil asetat (isobornyl acetate)n laboratuar hayvanlarnda kansere neden olma potansiyeline ilikin veriler mevcut deildi. zobornil asetat (isobornyl acetate)n insanlarda kansere neden olma potansiyeli ABD EPA IRIS program, Uluslararas Kanser Aratrma Ajans veya ABD Ulusal Toksikoloji Program 14. Kanserojen Raporu tarafndan deerlendirilmemitir.

zobornil asetat (isobornyl acetate) için (USEPA / OPP Pestisit Kodu: 128875) 0 etiket eleiyor. / SRP: ABD’de u anda kullanm için kaytl deildir, ancak onaylanm pestisit kullanmlar periyodik olarak deiebilir ve bu nedenle u anda onaylanm kullanmlar için federal, eyalet ve yerel yetkililere danlmaldr.

zobornil asetat (isobornyl acetate), sabun, banyo ürünleri ve oda spreyleri için büyük miktarlarda kullanlr. Bununla birlikte, izobornil asetatn balca kullanm kafur üretiminde bir ara üründür.

zobornil asetat (isobornyl acetate), asidik katalizörlerin (örnein sülfürik asit) varlnda veya bir stiren-divinilbenzen asit iyon deitirici üzerinde kamfen ve asetik asitten hazrlanr.

zobornil asetat (isobornyl acetate) kalntlar, sadece büyüyen ekinlere uygulanan pestisit formülasyonlarnda inert (veya bazen aktif) bileenler olarak iyi tarm uygulamasna uygun olarak kullanldnda tolerans gerekliliinden muaftr.

TANIMLAMA VE KULLANIM: zobornil asetat (isobornyl acetate) sabunlarda, deterjanlarda, kremlerde ve losyonlarda ve parfümlerde kullanlr. NSAN ÇALIMALARI: 25 gönüllü üzerinde maksimizasyon testi yapld. Materyal,% 10’luk bir konsantrasyonda test edildi ve hiçbir hassaslatrma reaksiyonu üretmedi. HAYVAN ÇALIMALARI: zobornil asetat (isobornyl acetate), oklüzyon altnda 24 saat boyunca bozulmam veya anm tavan derisine tam kuvvetle uyguland. zobornil asetat (isobornyl acetate), sçanlara 13 hafta süreyle 0, 15, 90 veya 270 mg / kg vücut arl dozlarnda günlük olarak uyguland. Erkek sçanlarda 90 mg / kg ve 270 mg / kg / gün nefrotoksisite iaretleri ve 270 mg / kg hepatotoksisite belirtileri vard. zobornil asetat (isobornyl acetate), sçanlarda 1 nesil üreme çalmasnda aratrlm ve geliimsel toksisite üretmemitir. Doz periyodu boyunca 100 ve / veya 300 mg / kg / gün ebeveyn nesli erkek ve dii sçanlarda ar tükürük salgs görüldü ve kadnlarda 300 mg / kg / gün düük idrarla lekeli abdominal kürk insidans görüldü. gebelik dönemi.

zobornil asetat (isobornyl acetate)n tuvalet sularnda, banyo müstahzarlarnda, antiseptiklerde, sabunlarda, sentetik kafur yapmnda ve aroma maddesi olarak üretimi ve kullanm, çeitli atk akmlar yoluyla çevreye salnmasna neden olabilir. ne kokularnn ve ameliyathane spreylerinin kartrlmasnda kullanlmas, dorudan çevreye salnmasna neden olacaktr. zobornil asetat (isobornyl acetate), çok çeitli bitkilerde ve dier bitkilerde rapor edilir. Havaya salnrsa, 25 ° C’de 0,11 mm Hg’lik tahmini buhar basnc, izobornil asetatn atmosferde yalnzca bir buhar olarak var olacan gösterir. Buhar faz izobornil asetat, atmosferde fotokimyasal olarak üretilen hidroksil radikalleri ile reaksiyona girerek bozunacaktr; havada bu reaksiyonun yar ömrünün 50 saat olduu tahmin edilmektedir. zobornil asetat (isobornyl acetate),> 290 nm dalga boylarnda absorbe eden kromoforlar içermez ve bu nedenle, güne nda dorudan fotolize duyarl olmas beklenmez. Topraa salnrsa, izobornil asetatn tahmini 420’lik Koc’a göre orta derecede hareketlilie sahip olmas beklenir. Nemli toprak yüzeylerinden buharlamann, 9.5X10-5 atm-cu m’lik tahmini Henry Yasas sabitine dayanan önemli bir kader süreci olmas beklenir. /köstebek. zobornil asetat (isobornyl acetate), 0.11 mm Hg’lik tahmini bir buhar basncna sahiptir ve çevresel koullar altnda bir sv olarak mevcuttur; bu nedenle izobornil asetat kuru topraktan buharlaabilir. OECD Biyobozunurluk testini kullanarak, izoborneol asetat 10 günde biyolojik olarak bozunmutur, bu da biyolojik bozunmann toprakta veya suda önemli bir çevre kaderi süreci olduunu göstermektedir. Suya salnrsa, izobornil asetatn tahmini Koc’a göre askda katlara ve çökeltiye adsorbe olmas beklenir. Su yüzeylerinden buharlamann, bu bileiin tahmini Henry Yasas sabitine dayanan önemli bir kader süreci olmas bekleniyor. Model nehir ve model göl için tahmini volatilizasyon yar ömürleri srasyla 17 saat ve 9,5 gündür. 320 tahmini BCF, suda yaayan organizmalardaki biyokonsantrasyon potansiyelinin orta düzeyde olduunu göstermektedir. Hidrolizin, srasyla 7 ve 8 pH deerlerinde 2,3 yllk ve 84 günlük tahmini baz katalizörlü ikinci derece yar ömürlerle gösterildii gibi önemli bir çevresel kader süreci olmas beklenmemektedir. zobornil asetat (isobornyl acetate)a mesleki maruziyet, izobornil asetatn üretildii veya kullanld iyerlerinde bu bileiin solunmas ve dermal temas yoluyla meydana gelebilir. zleme verileri, genel popülasyonun ortam havasnn solunmas, yiyeceklerin yutulmas ve izobornil asetat içeren tüketici ürünleriyle deri temas yoluyla izobornil asetata maruz kalabileceini göstermektedir.

zobornil asetat (isobornyl acetate), çok çeitli bitkilerde ve dier bitkilerde bildirilmektedir (1). Çam ve köknar aaçlarndan doal bir salmdr (2). Bileiin timus, Parmesan peyniri, dereotu otu, Ocimum basilicum, biberiye ve muhallebi elmada meydana geldii bildirilmektedir (3).

zobornil asetat (isobornyl acetate)n tuvalet sularnda, banyo müstahzarlarnda, antiseptiklerde, sabunlarda, sentetik kafur yapmnda (1) ve aroma maddesi (1,2) olarak üretimi ve kullanm çeitli atk akmlar yoluyla çevreye salnmasna neden olabilir. Çam inesi kokularnn ve ameliyathane spreylerinin (1) kartrlmasnda kullanlmas, dorudan çevreye (SRC) salnmasna neden olacaktr.

KARASAL FATE: Bir snflandrma emasna (1) dayal olarak, bir yap tahmin yönteminden (2) belirlenen tahmini Koc deeri 420 (SRC), izobornil asetatn toprakta orta derecede hareketlilie (SRC) sahip olmasnn beklendiini gösterir. zobornil asetat (isobornyl acetate)n nemli toprak yüzeylerinden buharlamasnn, bir parça sabiti tahmin yöntemi kullanlarak gelitirilen 9.5X10-5 atm-cu m / mol (SRC) tahmini Henry Yasas sabiti verildiinde önemli bir kader süreci (SRC) olmas beklenir (2) . zobornil asetat (isobornyl acetate), 0.11 mm Hg (2) tahmini buhar basncna sahiptir ve çevresel koullar altnda bir sv olarak mevcuttur; bu nedenle izobornil asetat kuru topraktan buharlaabilir. OECD Biyobozunurluk testini kullanarak, izoborneol asetat 10 günde biyolojik olarak parçalanmtr (3), bu da biyolojik bozunmann toprakta önemli bir çevre kaderi süreci (SRC) olduunu düündürmektedir.

ATMOSFERK KADER: Atmosferde (1) yar uçucu organik bileiklerin bir gaz / partikül bölme modeline göre, 25 ° C’de (SRC) tahmini buhar basncna sahip izobornil asetat (SRC), fragman sabiti yöntemiyle belirlenir. (2), ortam atmosferinde yalnzca bir buhar olarak bulunmas beklenmektedir. Buhar faz izobornil asetat, atmosferde fotokimyasal olarak üretilen hidroksil radikalleri (SRC) ile reaksiyona girerek bozulur; Bu reaksiyonun havada yarlanma ömrü, bir yap tahmin yöntemi kullanlarak türetilen 25 ° C’de 7.7X10-12 cu cm / molekül-saniye hz sabitinden hesaplanan 50 saat (SRC) olarak tahmin edilmektedir. (2). zobornil asetat (isobornyl acetate),> 290 nm (3) dalga boylarnda absorbe eden kromoforlar içermez ve bu nedenle, güne ile dorudan fotolize (SRC) duyarl olmas beklenmez.

AEROBK: zobornil asetat (isobornyl acetate), OECD Hazr Biyobozunurluk testinde 10 günde biyolojik olarak bozunmutur. Bileik, srasyla birincil yerçekimsel çökeltme ve aktif çamur artma ilemi altndaki atk su artma tesislerinde% 29.0 ve% 99.8 çkarld (1).

zobornil asetat (isobornyl acetate)n fotokimyasal olarak üretilen hidroksil radikalleri ile buhar faz reaksiyonu için hz sabiti, bir yap tahmin yöntemi (1) kullanlarak 25 ° C’de 7.7X10-12 cu cm / molekül-saniye olarak tahmin edilmitir (1). Bu, cu cm (1) bana 5X10 + 5 hidroksil radikal atmosferik konsantrasyonda yaklak 50 saatlik bir atmosferik yar ömre karlk gelir. 9.5X10-2 L / mol-sn’lik (SRC) bir baz katalizli ikinci dereceden hidroliz hz sabiti, bir yap tahmin yöntemi (1) kullanlarak tahmin edildi; bu, srasyla 7 ve 8 pH deerlerinde 2,3 yllk ve 84 günlük yar ömre karlk gelir (1). zobornil asetat (isobornyl acetate),> 290 nm (2) dalga boylarnda absorbe eden kromoforlar içermez ve bu nedenle, güne ile dorudan fotolize (SRC) duyarl olmas beklenmez.

zobornil asetat (isobornyl acetate) (SRC) için balkta tahmini BCF deeri 4,30 (1) log Kow ve regresyondan türetilmi denklem (2) kullanlarak hesaplanmtr. Bir snflandrma emasna (3) göre, bu BCF, suda yaayan organizmalardaki biyokonsantrasyon potansiyelinin yüksek olduunu (SRC) önermektedir.

Moleküler balant indekslerine (1) dayal bir yap tahmin yöntemi kullanlarak, izobornil asetatn Koc deerinin 420 (SRC) olduu tahmin edilebilir. Bir snflandrma emasna (2) göre, bu tahmini Koc deeri, izobornil asetatn topraktaki (SRC) hareketlilii azaltmasnn beklendiini göstermektedir.

TANIMLAMA: zobornil asetat (isobornyl acetate), renksiz ila saman rengi bir svdr. Çam inesi gibi bir kokusu vardr. Suda pek çözünür deildir. zobornil asetat (isobornyl acetate), birçok bitkide doal bir bileendir. KULLANIM: zobornil asetat (isobornyl acetate), önemli bir ticari kimyasaldr. Parfümlü sabunlarda, oda spreylerinde ve kafur yapmnda kullanlr. Ayn zamanda tatlandrc bir bileen olarak da kullanlr. MARUZ KALMA: zobornil asetat (isobornyl acetate) kullanan içiler buharlar soluyabilir veya dorudan ciltle temas edebilir. Genel popülasyon, buharlara, deri temasna ve izobornil asetat ile tatlandrlm yiyeceklerin tüketimine maruz kalabilir. zobornil asetat (isobornyl acetate) ortama salnrsa havada parçalanacaktr. Güne ndan parçalanmas beklenmez. Nemli toprak ve su yüzeylerinden havaya geçecektir. Toprakta hareket etmesi bekleniyor. Mikroorganizmalar tarafndan parçalanacak ve balklarda birikmesi bekleniyor. RSK: Dorudan cilt maruziyetini takiben gönüllülerde alerjik cilt reaksiyonlar gözlenmedi. zobornil asetat (isobornyl acetate)n insanlarda toksik etkiler üretme potansiyeline ilikin baka veriler mevcut deildi. zobornil asetat (isobornyl acetate), laboratuar hayvanlarnda hafif bir cilt tahri edicidir. Böbrek ve karacier hasar ve böbrek fonksiyonunda deiiklikler, zaman içinde orta ila yüksek oral izobornil asetat dozlarna tekrar tekrar maruz kaldktan sonra laboratuvar hayvanlarnda bildirilmitir. Düük dozlarda hiçbir etki bildirilmemitir. Gebelik öncesinde ve srasnda yüksek oral dozlarda izobornil asetata maruz kalan laboratuar hayvanlarnda ksrlk, düük veya doum kusurlarna dair hiçbir kant bildirilmemitir. zobornil asetat (isobornyl acetate)n laboratuar hayvanlarnda kansere neden olma potansiyeline ilikin veriler mevcut deildi. zobornil asetat (isobornyl acetate)n insanlarda kansere neden olma potansiyeli ABD EPA IRIS program, Uluslararas Kanser Aratrma Ajans veya ABD Ulusal Toksikoloji Program 14. Karsinojen Raporunda deerlendirilmemitir.

zobornil asetat (isobornyl acetate) için Henry Yasas sabiti, bir parça sabiti tahmin yöntemi (1) kullanlarak gelitirilen 9.5X10-5 atm-cu m / mol (SRC) olarak tahmin edilmektedir. Bu Henry Yasas sabiti, izobornil asetatn su yüzeylerinden buharlamasnn beklendiini gösterir (2). Bu Henry Yasas sabitine dayanarak, bir nehir modelinden (1 m derinlik, 1 m / sn akan, 3 m / sn rüzgar hz) (2) buharlama yar ömrü 17 saat (SRC) olarak tahmin edilmektedir. Bir gölden modeldeki uçuculuk yar ömrü (1 m derinlik, 0,05 m / sn akma, 0,5 m / sn rüzgar hz) (2) 9,5 gün (SRC) olarak tahmin edilmektedir. zobornil asetat (isobornyl acetate)n Henry Yasas sabiti, nemli toprak yüzeylerinden buharlamann meydana gelebileceini gösterir (SRC). zobornil asetat (isobornyl acetate), 0,11 mm Hg’lik (SRC) tahmini buhar basncna sahiptir, fragman sabiti yöntemiyle (13) belirlenir ve çevresel koullar altnda sv olarak bulunur : bu nedenle, izobornil asetat kuru topraktan (SRC) buharlaabilir. Bir Georgetown, DE anaerobik olarak sindirilmi belediye çamuruna 21 dier koku maddesi ile birlikte eklendiinde ve dört topraa (kumlu tarm tnl, siltli orta bat tarmsal balçk, yüksek organik karbonlu toprak ve yüksek derecede ypranm oksit bakmndan zengin) uygulandnda izobornil asetat bir hafta içinde dalr. toprak) (3).

zobornil asetat (isobornyl acetate), Eylül 1997’de Loveland, OH’deki aktif çamur artma tesisinde 3 günlük bir sürenin ardndan belediye atk su giriinde ortalama 5.130 ng / L konsantrasyonda ve artlm atk suda ortalama 24 ng / L konsantrasyonda rapor edilmitir. Damlatmal filtre atk su artmna tabi tutulduklarnda srasyla 2,830 ve 58 ng / L’lik giri ve çk ortalama konsantrasyonlar (1).

zobornil asetat (isobornyl acetate), analiz edilen hem% 30 hem de% 5 ya içerii örneklerinde frankfurterlerde mevcuttu (1). Sosislerden elde edilen headspace uçucular için test edildi ancak tespit edilmedi (2).

zobornil asetat (isobornyl acetate)n çam kokulu plug-in oda spreylerinden kaynaklanan emisyonlarda belirgin olmad tespit edildi (1).

zobornil asetat (isobornyl acetate)a mesleki maruziyet, izobornil asetatn üretildii veya kullanld iyerlerinde bu bileiin solunmas ve dermal temas yoluyla meydana gelebilir. zleme verileri, genel popülasyonun ortam havasnn solunmas, yiyeceklerin yutulmas ve izobornil asetat içeren tüketici ürünleriyle deri temas yoluyla izobornil asetata maruz kalabileceini göstermektedir.

zobornil asetat (isobornyl acetate) kozalakl bitkisel kafurlu ine yaprakl topraks ine inesi çam balzamik kafur aromaterapi leylak erkek fougere ine odunsu lavanta ladin narenciye hindistan cevizi zencefil et meyve aromasdr.

zobornil asetat (isobornyl acetate) (bir bornil asetat izomeri), mikroorganizmalar için inhibe edici olduu gözlemlenen birçok uçucu yan bir bileenidir. nhalasyondan sonra fareler üzerinde yattrc etkiye sahip olduu da gösterilmitir. zobornil asetat (isobornyl acetate) esas olarak kozmetikte aroma ve koku maddesi olarak kullanlr.

zobornil asetat (isobornyl acetate) (IBCH, Sandenol), sandal aac yana benzer aromas nedeniyle esas olarak koku olarak kullanlan organik bir bileiktir. Kimyasal yaps, sandal aac yann temel bileenleri olan hem α-Santalol hem de β-Santalol [3] ile yakndan ilgilidir.

Sandal aac aaçlar ar hasat nedeniyle tehlikeye girer [4], bu da doal ya için yüksek bir maliyete yol açar. IBCH bu nedenle doal ürüne ekonomik bir alternatif olarak üretilir.

zobornil asetat (isobornyl acetate) uygulamalar

zobornil asetat (isobornyl acetate), parfümeri endüstrisinde kullanlan en önemli kimyasallardan biridir. Banyo malzemeleri ve sabunlarda aroma maddesi ve antiseptik olarak kullanlr. Ana uygulamalardan biri kafur üretmek için bir ara üründür.

zobornil asetat (isobornyl acetate)n çözünürlüü

Su ile karmaz veya kartrlmas zor deildir.

zobornil asetat (isobornyl acetate), bir tür asetat esterdir. Asetat ve kamfen arasnda esterletirme yoluyla üretilebilir. Kokulu bir çeit tatlandrcdr. Tbbi sentetik kafur üretimi için gerekli ara ürün olarak kullanlabilir.

ISOBORNYL ACETATE (ZOBORNL ASETAT)

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ISOBORNYL ACETATE (ZOBORNL ASETAT)

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