ISOBUTYLCARBINOL

ISOBUTYLCARBINOL

ISOBUTYLCARBINOL = ISOAMYL ALCOHOL  = ISOPENTANOL = 3-METHYLBUTANOL = ISOAMYLOL = 3-METHYLBUTAN-1-ol = IAA

EC / List no.: 204-633-5

CAS no.: 123-51-3

Mol. formula: C5H12O

ISOBUTYLCARBINOL  is a primary alcohol, a volatile organic compound and an alkyl alcohol. ISOBUTYLCARBINOL  derives from a hydride of an isopentane.

ISOBUTYLCARBINOL  is a colorless liquid with a mild, choking alcohol odor. 

ISOBUTYLCARBINOL  is less dense than water, soluble in water. Hence ISOBUTYLCARBINOL  floats on water. 

ISOBUTYLCARBINOL  produces an irritating vapor. 

ISOBUTYLCARBINOL  is a specialty solvent that finds extensive use for flavours and fragrances and is used in the production of many synthetic flavours. 

Its relatively low eco-tox profile finds it use growing in other areas. 

ISOBUTYLCARBINOL  is used as a solvent for the preparation of synthetic fruit flavours, such as apricot, banana, cheery, greengage, malt, orange, plum and whiskey flavours, and is a raw material in the production of synthetic banana oil. 

ISOBUTYLCARBINOL is one of the components of the aroma of the black truffle. 

ISOBUTYLCARBINOL’s blend of properties makes it suitable for use as a foam suppressant, affecting the surface tension of micro-emulsions and causing foam breaking.

Isoamylol is an primary alcohol that is butan-1-ol in which a hydrogen at position 3 has been replaced by a methyl group. 

Isoamylol has a role as a xenobiotic metabolite, a Saccharomyces cerevisiae metabolite and an antifungal agent. 

Isoamylol is a primary alcohol, a volatile organic compound and an alkyl alcohol. Isoamylol derives from a hydride of an isopentane.

ISOBUTYLCARBINOL  is a colorless liquid with the formula C5H12O, specifically (H3C–)2CH–CH2–CH2–OH. It is one of several isomers of amyl alcohol (pentanol). 

ISOBUTYLCARBINOL  is also known as ISOBUTYLCARBINOL, isopentanol, or (in the IUPAC recommended nomenclature) 3-methyl-butan-1-ol. 

An obsolete name for ISOBUTYLCARBINOL  was isobutyl carbinol.

ISOBUTYLCARBINOL  is an ingredient in the production of banana oil, an ester found in nature and also produced as a flavouring in industry. 

ISOBUTYLCARBINOL  is a common fusel alcohol, produced as a major by-product of ethanol fermentation.

ISOBUTYLCARBINOL  is one of the flavour and fragrance chemicals. 

ISOBUTYLCARBINOL  is a speciality solvent often noted for its distinctive odour – which smells like pear drops.

ISOBUTYLCARBINOL  is a speciality solvent that finds extensive use for flavours and fragrances and is used in the production of many synthetic flavours. 

Its relatively low eco-tox profile finds it use growing in other areas.

ISOBUTYLCARBINOL  or Isopentanol, also known as ISOBUTYLCARBINOL or iso-amylalkohol, belongs to the class of organic compounds known as primary alcohols. 

Primary alcohols are compounds comprising the alcohol functional group, attached to a primary carbon, with the general structure RCOH (R=alkyl, aryl). 

ISOBUTYLCARBINOL  is a very hydrophobic molecule, practically insoluble in water but readily soluble in organic solvents such as methanol, ethanol and ethyl acetate. 

Thus, isopentanol is considered to be a fatty alcohol lipidic molecule. 

ISOBUTYLCARBINOL is one of several isomers of amyl alcohol. 

It is a by-product of gut microbial fermentation (PMID: 17452087). 

Isopentanol is an alcoholic, banana, and burnt tasting compound. 

Due to its flavour and aroma, it is an ingredient in the production of banana oil, an ester found in nature and also produced as a flavouring in industry. 

ISOBUTYLCARBINOL  can be produced by 3-methylbutanal reductase (EC 1.1.1.265) from 3-methylbutanal. 

In alcoholic beverages, ISOBUTYLCARBINOL is also the major higher chain alcohol and it is present in cider, mead, beer, wine, and spirits to varying degrees, being a product of the fermentation of starches. 

Isopentanol has been shown to induce expression of CYP3A and CYP2E1 in human liver (PMID: 7574728).

ISOBUTYLCARBINOL  (Isopentanol)

ISOBUTYLCARBINOL , also known as Isopentanol is a clear, colorless, liquid organic compound that is one of several isomers of amyl alcohol. It is a principal ingredient in the production of banana oil, a natural ester used in the flavoring industry. It is also used as an antifoaming agent in the Chloroform: Isomyl Alcohol reagent.

APPLICATIONS

ISOBUTYLCARBINOL  is used as a solvent for the preparation of synthetic fruit flavours, such as apricot, banana, cheery, greengage, malt, orange, plum and whiskey flavours, and is a raw material in the production of synthetic banana oil. 

ISOBUTYLCARBINOL  is one of the components of the aroma of the black truffle. ISOBUTYLCARBINOL  is also used for estimation of fat in milk and milk products.

ISOBUTYLCARBINOL  is the main ingredient of Kovac’s Reagent used for the bacterial diagnostic Indole Test.

Its blend of properties makes it suitable for use as a foam suppressant, affecting the surface tension of micro-emulsions and causing foam breaking.

As a solvent, ISOBUTYLCARBINOL  is finding increasing use in a wide number of industrial applications. 

In solvency power, ISOBUTYLCARBINOL  falls between common hydrocarbon solvents and lower molecular weight ketones. Paraffin wax is soluble in hot ISOBUTYLCARBINOL .

In formulation, some high molecular weight esters and polar plastics incorporate ISOBUTYLCARBINOL -based systems e.g. cellulose esters. Shellac and urea formaldehyde.

ISOBUTYLCARBINOL  is a diluent in some printing inks, lacquers and gums.

In pharmaceuticals, ISOBUTYLCARBINOL  is the initial raw material for a number of drug preparations such as Barbamil, Validol, Corvalol and amyl nitrite.

A derivative of ISOBUTYLCARBINOL , the p-methoxycinnamate is used as a UV absorber in some cosmetic formulations, and the product itself finds application as a cosmetic flavouring and in perfume.

ISOBUTYLCARBINOL  is used in the following products: lubricants and greases, polishes and waxes, anti-freeze products, washing & cleaning products, adhesives and sealants, coating products, finger paints, perfumes and fragrances and cosmetics and personal care products.

ISOBUTYLCARBINOL  is routinely used in molecular biology, especially in the purification of DNA. 

ISOBUTYLCARBINOL  is widely used in conjunction with phenol and chloroform (25:24:1 phenol : chloroform : ISOBUTYLCARBINOL ) for the removal of proteins from the nucleic acid solutions by extraction. 

ISOBUTYLCARBINOL  is added to the phenol solution to help inhibit RNase activity and to help prevent the solubilization in the phenol phase of long RNA molecules with long poly(A) portions. 

ISOBUTYLCARBINOL  will also help in reducing the foaming during the extraction process.

ISOBUTYLCARBINOL  is also used in the extraction of ethidium bromide from DNA solutions and in the radiolabeling of RNA transcripts in nuclei that have been isolated from tissue. 

ISOBUTYLCARBINOL  has various miscellaneous uses which include HPLC analysis of various pharmaceuticals and metabolites, analysis of oxidized and reduced pyridine nucleotides and adenylates in organic phenol extracts from mitochondria, isolation of mRNA from a thermophilic cyanobacterium, Solvent for fats, resins, alkaloids, Manufacturing isoamyl (amyl) compounds, isovaleric acid, mercury fulminate, pyroxylin, artificial silk, lacquers, smokeless powders, for dehydrating celloidin solutions, for determining fat in milk etc.

ISOBUTYLCARBINOL  is a colorless, clear liquid with the chemical formula (CH3)2CHCH2CH2OH and the CAS # 123-51-3. The nontoxic compound has a mild, choking disagreeable odor. It is less dense than water, soluble in water, and floats on water. Its main use in industry is as a food additive and flavoring agent. It is manufactured from light petroleum by fractional distillation.

ISOBUTYLCARBINOL  is used as a solvent in the manufacture of photographic and pharmaceutical chemicals.

Uses: Synthetic flavor, intermediate in preparation of pharmaceuticals, for isoamyl acetate and other esters, for dithiophosphate esters (lubricating oil additive and hydraulic fluid additive).

ISOBUTYLCARBINOL  (also known as ISOBUTYLCARBINOL) is a colorless liquid with the formula (CH3)2CHCH2CH2OH. It is one of several isomers of amyl alcohol. It is an ingredient in the production of banana oil, an ester found in nature and also produced as a flavouring in industry. It is a common fusel alcohol, produced as a major by-product of ethanol fermentation. It is also an ingredient of Kovac’s reagent, used for the bacterial diagnostic indole test.

ISOBUTYLCARBINOL  is a cyanobacterial volatile organic compound that has been identified as one of the main aroma/flavor constituents in banana fruit, karanda fruits and in whey spirit.

Preferred IUPAC name: 3-Methylbutan-1-ol

Other names: 

3-Methyl-1-butanol

ISOBUTYLCARBINOL

Isopentanol

Isobutylcarbinol

Identifiers

CAS Number: 123-51-3 

Properties

Chemical formula: C5H12O

Molar mass: 88.148 g/mol

Appearance: Clear, colorless liquid

Density: 0.8104 g/cm3 at 20 °C

Melting point: −117 °C (−179 °F; 156 K)

Boiling point: 131.1 °C (268.0 °F; 404.2 K)

Solubility in water: Slightly soluble, 28 g/L

Solubility: Very soluble in acetone, diethyl ether, ethanol

Vapor pressure: 28 mmHg (20 °C)

Magnetic susceptibility (χ): −68.96·10−6 cm3/mol

Viscosity: 3.692 mPa·s

Thermochemistry

Heat capacity (C): 2.382 J/g·K

Std enthalpy of formation (ΔfH⦵298): 

−356.4 kJ/mol (liquid)

−300.7 kJ/mol (gas)

Hazards

Flash point: 43 °C (109 °F; 316 K)

Autoignition temperature: 350 °C (662 °F; 623 K)

Explosive limits: 1.2–9%

Lethal dose or concentration (LD, LC): LD50 (median dose): 3438 mg/kg (rabbit, oral) 1300 mg/kg (rat, oral)

Occurrence

ISOBUTYLCARBINOL  is one of the components of the aroma of Tuber melanosporum, the black truffle.

The compound has also been identified as a chemical in the pheromone used by hornets to attract other members of the hive to attack.

Isoamyl acetate is a component of the natural aroma of bananas, especially the Gros Michel variety.

Extraction of ISOBUTYLCARBINOL  from fusel oil:

ISOBUTYLCARBINOL  can be separated from fusel oil by either of two methods: shaking with strong brine solution and separating the oily layer from the brine layer; distilling it and collecting the fraction that boils between 125 and 140 °C. 

Further purification is possible with this procedure: shaking the product with hot limewater, separating the oily layer, drying the product with calcium chloride, and distilling it, collecting the fraction boiling between 128 and 132 °C.

Synthesis of ISOBUTYLCARBINOL 

ISOBUTYLCARBINOL  can be synthesized by condensation of isobutene and formaldehyde which produces isoprenol and hydrogenation. 

ISOBUTYLCARBINOL  is a colourless liquid of density 0.8247 g/cm3 (0 °C), boiling at 131.6 °C, slightly soluble in water, and easily dissolved in organic solvents. 

ISOBUTYLCARBINOL  has a characteristic strong smell and a sharp burning taste. 

Amyl alcohol has an oral LD50 of 200 mg/kg in mice, suggesting that it is significantly more toxic than ethanol. 

On passing the vapour through a red-hot tube, it decomposes into acetylene, ethylene, propylene, and other compounds. 

It is oxidized by chromic acid to isovaleraldehyde, and it forms addition compounds crystals with calcium chloride and tin(IV) chloride.

Uses of ISOBUTYLCARBINOL  :

Besides its use in the synthesis of banana oil, ISOBUTYLCARBINOL  is also an ingredient of Kovac’s reagent, used for the bacterial diagnostic indole test.

ISOBUTYLCARBINOL  is also used as an antifoaming agent in the chloroform ISOBUTYLCARBINOL  reagent.

ISOBUTYLCARBINOL  is used in a phenol–chloroform extraction mixed with the chloroform to further inhibit RNase activity and prevent solubility of RNAs with long tracts of poly-adenine.

Uses: ISOBUTYLCARBINOL  is used as a solvent, paint stripper, and intermediate in the photographic and pharmaceutical industries; [ACGIH]

1-Butanol, 3-methyl-

IUPAC names

3-Methyl-1-butanol

3-methyl-1-butanol

3-methylbut-1-ol

3-METHYLBUTAN-1-OL

3-Methylbutan-1-ol

3-methylbutan-1-ol

3-methylbutanol

3-metil-1-butanolo

Iso-Amyl alcohol

ISOBUTYLCARBINOL 

ISOBUTYLCARBINOL 

ISOBUTYLCARBINOL 

ISOBUTYLCARBINOL , ISOBUTYLCARBINOL

Methyl-1-butanol

Trade names

1-Butanol, 3-methyl-(9CI)

2-Methyl-4-butanol

3-Methyl-1-butanol

IAA

iso-Amyl alcohol

iso-Pentanol

ISOBUTYLCARBINOL 

Isoamylol

Isobutyl carbinol

Isopentanol

ISOBUTYLCARBINOL (8CI)

SYNONYMS :

ISOBUTYLCARBINOL 

3-Methyl-1-butanol

ISOBUTYLCARBINOL

3-Methylbutan-1-ol

123-51-3

Isopentanol

3-Methylbutanol

1-Butanol, 3-methyl-

Isoamylol

Isobutylcarbinol

Iso-amylalkohol

Fusel Oil

Iso-amyl alcohol

2-Methyl-4-butanol

Isobutyl carbinol

ISOAMYLALCOHOL

Alcool isoamylique

Fermentation amyl alcohol

Alcool amilico

Amylowy alkohol

Isoamyl alkohol

i-Amyl Alcohol

Primary ISOBUTYLCARBINOL 

3-Metil-butanolo

isopentan-1-ol

MFCD00002934

ISOBUTYLCARBINOL  (natural)

isoamyl-alcohol

3-Methyl-Butan-1-Ol

ISOBUTYLCARBINOL , primary

UNII-DEM9NIT1J4

3-methyl-Butanol

NSC 1029

Methyl-3-butan-1-ol

Butan-1-ol, 3-methyl

DEM9NIT1J4

Fuseloel

Huile de fusel

CHEBI:15837

3-METHYL-BUTAN-(1)-OL

3-Methyl-1-butanol, ACS reagent

iso-pentanol

WLN: Q2Y1 & 1

3-Methyl-1-butanol, 98%, pure

FEMA Number 2057

Isoamyl alkohol [Czech]

Alcool amilico [Italian]

Amylowy alkohol [Polish]

Iso-amylalkohol [German]

1-Hydroxy-3-Methylbutane

Alcool isoamylique [French]

3-Metil-butanolo [Italian]

FEMA No. 2057

HSDB 605

EINECS 204-633-5

ISOBUTYLCARBINOL (8CI)

3-Methyl-1-butanol, 99%, for biochemistry, AcroSeal(R)

iso-amylalcohol

isopentylalcohol

Isopentylalkohol

AI3-15288

CCRIS 8806

3-methylbutanoI

3-methyl butanol

3-methyl 1-butanol

3-methyl-1 butanol

3-methylbutane-1-ol

Butanol, 3-methyl-

ISOBUTYLCARBINOL  (primary and secondary)

ACMC-1ADLL

6423-06-9

DSSTox_CID_5469

EC 204-633-5

DSSTox_RID_77799

DSSTox_GSID_25469

3-Methyl-1-butanol, 98%

CHEMBL372396

QSPL 002

DTXSID3025469

ISOBUTYLCARBINOL , >=98%, FG

NSC1029

NSC7905

3-Methyl-1-butanol, for analysis

ZINC896830

ISOBUTYLCARBINOL  (3-methyl butanol)

NSC-1029

NSC-7905

1-$l^{1}-oxidanyl-3-methylbutane

3-Methylbutanol, analytical standard

EINECS 229-179-5

Tox21_302359

7340AF

ANW-18132

LMFA05000108

STL282718

3-Methyl-1-butanol A.C.S. Reagent

3-Methyl-1-butanol, LR, >=98%

AKOS000118739

Magnesium bis(3-methylbutan-1-olate)

NATURAL ISOBUTYLCARBINOL  P & F

DB02296

MCULE-7411270401

3-Methyl-1-butanol, mixture of isomers

3-Methyl-1-butanol, p.a., 99.8%

ISOBUTYLCARBINOL , natural, >=98%, FG

3-Methyl-1-butanol, analytical standard

NCGC00255329-01

3-Methyl-1-butanol, anhydrous, >=99%

CAS-123-51-3

3-Methyl-1-butanol, reagent grade, 98%

3-Methyl-1-butanol, technical grade, 95%

ISOBUTYLCARBINOL  ULTRA PURE GRADE 1L

FT-0616032

I0289

1973-EP2281899A2

1973-EP2316937A1

3-Methyl-1-butanol, ACS reagent, >=98.5%

3-Methyl-1-butanol, biotech. grade, >=99%

3-Methyl-1-butanol, ReagentPlus(R), >=99%

C07328

74374-EP2269986A1

74374-EP2308857A1

74374-EP2380568A1

NATURAL ISOBUTYLCARBINOL  – TECHNICAL GRADE

117932-EP2287147A2

117932-EP2298768A1

3-Methyl-1-butanol, SAJ first grade, >=96.0%

Q223101

3-Methyl-1-butanol, JIS special grade, >=98.0%

F0001-0367

Z955123582

UNII-2NK7O363Q6 component PHTQWCKDNZKARW-UHFFFAOYSA-N

3-Methylbutanol, BioReagent, for molecular biology, >=98.5%

3-Methylbutanol, puriss. p.a., ACS reagent, >=98.5% (GC)

3-Methylbutanol, BioUltra, for molecular biology, >=99.0% (GC)

3-Methyl-1-butanol, United States Pharmacopeia (USP) Reference Standard

3-Methylbutanol, p.a., ACS reagent, reag. ISO, reag. Ph. Eur., 98.5%

ISOBUTYLCARBINOL  must be stored to avoid contact with strong oxidizers, such as chlorine, and bromine, since violent reactions occur.

ISOBUTYLCARBINOL  is a colorless liquid. It has a disagreeable odor which causes coughing. Molecular weight=88.15 (primary-and sec-); specific gravity (H2O:1)=0.81 @ 20°C; boiling point=131 °C (primary); 116.3°C (secondary); freezing/melting point=−117.2°C (primary-); −69°C (sec-); vapor pressure=28 mmHg (primary-); 7.5 mmHg @24°C (sec-); vapor pressure=0.75 mmHg @ 13°C (primary-); flash point=43°C (cc); 55°C (oc) (primary-); 35°C (sec-); autoignition temperature=350°C. Explosive limits: LEL (primary-)=1.2% @ 100°C; UEL (primary-)=9.0% @100°C. Hazard identification (based on NFPA-704 M Rating System): Health 2, flammability 3, reactivity 0. Slightly soluble in water; solubility=2% @ 13.9°C.

Reactivity Alerts

Highly Flammable

Air & Water Reactions

Highly flammable. Water soluble.

Fire Hazard

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)

Health Hazard

Very high vapor concentrations irritate eyes and upper respiratory tract. Continued contact with skin may cause irritation. (USCG, 1999)

Reactivity Profile

ISOBUTYLCARBINOL  attacks plastics [Handling Chemicals Safely, 1980. p. 236]. Mixtures with concentrated sulfuric acid and strong hydrogen peroxide may cause explosions. Mixing with hypochlorous acid in water or water/carbon tetrachloride solution can generate isoamyl hypochlorites, which may explode, particularly on exposure to sunlight or heat. Mixing with chlorine would also yield isoamyl hypochlorites [NFPA 491 M, 1991]. Base-catalysed reactions with isocyanates can occur with explosive violence [Wischmeyer,1969].

Belongs to the Following Reactive Group(s)

Alcohols and Polyols

Potentially Incompatible Absorbents

Use caution: Liquids with this reactive group classification have been known to react with the absorbent listed below. More info about absorbents, including situations to watch out for…

Cellulose-Based Absorbents

Alternate Chemical Names

FERMENTATION AMYL ALCOHOL

FUSEL OIL

ISOBUTYLCARBINOL 

ISOBUTYLCARBINOL  (PRIMARY)

ISOBUTYL CARBINOL

ISOBUTYLCARBINOL

ISOBUTYLCARBINOL

ISOBUTYLCARBINOL {ISOBUTYLCARBINOL }

3-METHYL-1-BUTANOL

POTATO SPIRIT OIL

PRIMARY ISOBUTYLCARBINOL 

Other names: ISOBUTYLCARBINOL; Fermentation amyl alcohol; Fusel Oil; ISOBUTYLCARBINOL ; Isoamylol; Isobutyl carbinol; Isopentanol; 2-Methyl-4-butanol; 3-Methyl-1-butanol; 3-Methylbutanol; Alcool amilico; Alcool isoamylique; Amylowy alkohol; iso-amylalkohol; 3-Methylbutan-1-ol; 3-Metil-butanolo; ISOBUTYLCARBINOL , primary; Butanol, 3-methyl-; Butan-1-ol, 3-methyl; i-Amyl alcohol; Isopentan-1-ol; Methyl-3-butan-1-ol; NSC 1029; UN 1105; 3-methylbutanoI; ISOBUTYLCARBINOL  (3-methyl butanol)

ISOBUTYLCARBINOL  (isopentanol or 3-methylbutan-1-ol) that can be biologically produced is among the possible alcohols usable as an alternative fuel in internal combustion engines. 

ISOBUTYLCARBINOL  has a higher energy density than smaller alcohols (ca. 28.5 MJ/L, as compared to ca. 21 MJ/L for ethanol and 27 MJ/L for 1-butanol). It is less hydroscopic than ethanol and mixes better with hydrocarbons.

Synonyms

1-Butanol, 3-methyl-; 2-Methyl-4-butanol; 3-Methylbutan-1-ol; 3-Methylbutanol; 3-Metil-butanolo [Italian]; Alcool amilico [Italian]; Alcool isoamylique [French]; Amylowy alkohol [Polish]; Fermentation amyl alcohol; Fusel Oil; ISOAMYLALCOHOL; Iso-amylalkohol [German]; ISOBUTYLCARBINOL  (natural); Isoamyl alkohol [Czech]; Isoamylol; Isobutyl carbinol; Isobutylcarbinol; Isopentanol; ISOBUTYLCARBINOL; Primary ISOBUTYLCARBINOL ; [ChemIDplus]l

Apart from the primary metabolite ethanol, several higher alcohols are formed at different levels, of which ISOBUTYLCARBINOL  (Fig. 1B, descriptors: ‘alcoholic’, ‘vinous’, ‘sweet’) is the most abundant secondary metabolite and typically found well above its flavor threshold in beer. ISOBUTYLCARBINOL  has also some banana flavor character and has been identified above its threshold in banana, orange, mango, pineapple and passion fruit 

ISOBUTYLCARBINOL  is a banana oil or hot alcohol like flavour. It is very light but has a lingering taste and mouthfeel. It commonly occurs due to poor fermentation conditions – when the temperature is not correct or dissolved gases are not optimal.

APPLICATIONS

ISOBUTYLCARBINOL  is used as a solvent for the preparation of synthetic fruit flavours, such as apricot, banana, cheery, greengage, malt, orange, plum and whiskey flavours, and is a raw material in the production of synthetic banana oil. It is one of the components of the aroma of the black truffle. It is also used for estimation of fat in milk and milk products.

It is the main ingredient of Kovac’s Reagent used for the bacterial diagnostic Indole Test.

Its blend of properties makes it suitable for use as a foam suppressant, affecting the surface tension of micro-emulsions and causing foam breaking.

As a solvent, ISOBUTYLCARBINOL  is finding increasing use in a wide number of industrial applications. In solvency power, it falls between common hydrocarbon solvents and lower molecular weight ketones. Paraffin wax is soluble in hot ISOBUTYLCARBINOL .

In formulation, some high molecular weight esters and polar plastics incorporate ISOBUTYLCARBINOL -based systems e.g. cellulose esters. Shellac and urea formaldehyde.

ISOBUTYLCARBINOL  is a diluent in some printing inks, lacquers and gums.

In pharmaceuticals, it is the initial raw material for a number of drug preparations such as Barbamil, Validol, Corvalol and Isoamyl nitrite.

A derivative of ISOBUTYLCARBINOL , the p-methoxycinnamate is used as a UV absorber in some cosmetic formulations, and the product itself finds application as a cosmetic flavouring and in perfume.