ISOCETYL PALMITATE ( SO SETL PALMTAT)
ISOCETYL PALMITATE (zosetil Palmitat)
CAS No. : 127770-27-8
EC No. : –
Synonyms:
Isocetyl palmitate; Hexadecanoic acid, isohexadecyl ester; UNII-355356620Z; 127770-27-8; 355356620Z; SCHEMBL5873231; DTXSID2074584; ZINC100096069; Q27256425; 127770-27-8 [RN]; 14-Methylpentadecyl palmitate [ACD/IUPAC Name]; 14-Methylpentadecylpalmitat [German] [ACD/IUPAC Name]; Hexadecanoic acid, 14-methylpentadecyl ester [ACD/Index Name]; ISOCETYL PALMITATE; Palmitate de 14-méthylpentadécyle [French] [ACD/IUPAC Name]; 14-METHYLPENTADECYL HEXADECANOATE; Hexadecanoic acid, isohexadecyl ester; zosetil palmitat; ISOCETYL PALMITATE; SOCETL PALMTAT; ISOCETIL PALMITATE; isosetil palmitat; zosetl palmtate; IZOSETIL PALMITAT; Isocetyl palmitate; Hexadecanoic acid, isohexadecyl ester; UNII-355356620Z; 127770-27-8; 355356620Z; SCHEMBL5873231; DTXSID2074584; ZINC100096069; Q27256425; 127770-27-8 [RN]; 14-Methylpentadecyl palmitate [ACD/IUPAC Name]; 14-Methylpentadecylpalmitat [German] [ACD/IUPAC Name]; Hexadecanoic acid, 14-methylpentadecyl ester [ACD/Index Name]; ISOCETYL PALMITATE; Palmitate de 14-méthylpentadécyle [French] [ACD/IUPAC Name]; 14-METHYLPENTADECYL HEXADECANOATE; Hexadecanoic acid, isohexadecyl ester; zosetil palmitat; ISOCETYL PALMITATE; SOCETL PALMTAT; ISOCETIL PALMITATE; isosetil palmitat; zosetl palmtate; IZOSETIL PALMITAT; Isocetyl palmitate; Hexadecanoic acid, isohexadecyl ester; UNII-355356620Z; 127770-27-8; 355356620Z; SCHEMBL5873231; DTXSID2074584; ZINC100096069; Q27256425; 127770-27-8 [RN]; 14-Methylpentadecyl palmitate [ACD/IUPAC Name]; 14-Methylpentadecylpalmitat [German] [ACD/IUPAC Name]; Hexadecanoic acid, 14-methylpentadecyl ester [ACD/Index Name]; ISOCETYL PALMITATE; Palmitate de 14-méthylpentadécyle [French] [ACD/IUPAC Name]; 14-METHYLPENTADECYL HEXADECANOATE; Hexadecanoic acid, isohexadecyl ester; zosetil palmitat; ISOCETYL PALMITATE; SOCETL PALMTAT; ISOCETIL PALMITATE; isosetil palmitat; zosetl palmtate; IZOSETIL PALMITAT; Isocetyl palmitate; Hexadecanoic acid, isohexadecyl ester; UNII-355356620Z; 127770-27-8; 355356620Z; SCHEMBL5873231; DTXSID2074584; ZINC100096069; Q27256425; 127770-27-8 [RN]; 14-Methylpentadecyl palmitate [ACD/IUPAC Name]; 14-Methylpentadecylpalmitat [German] [ACD/IUPAC Name]; Hexadecanoic acid, 14-methylpentadecyl ester [ACD/Index Name]; ISOCETYL PALMITATE; Palmitate de 14-méthylpentadécyle [French] [ACD/IUPAC Name]; 14-METHYLPENTADECYL HEXADECANOATE; Hexadecanoic acid, isohexadecyl ester; zosetil palmitat; ISOCETYL PALMITATE; SOCETL PALMTAT; ISOCETIL PALMITATE; isosetil palmitat; zosetl palmtate; IZOSETIL PALMITAT; Isocetyl palmitate; Hexadecanoic acid, isohexadecyl ester; UNII-355356620Z; 127770-27-8; 355356620Z; SCHEMBL5873231; DTXSID2074584; ZINC100096069; Q27256425; 127770-27-8 [RN]; 14-Methylpentadecyl palmitate [ACD/IUPAC Name]; 14-Methylpentadecylpalmitat [German] [ACD/IUPAC Name]; Hexadecanoic acid, 14-methylpentadecyl ester [ACD/Index Name]; ISOCETYL PALMITATE; Palmitate de 14-méthylpentadécyle [French] [ACD/IUPAC Name]; 14-METHYLPENTADECYL HEXADECANOATE; Hexadecanoic acid, isohexadecyl ester; zosetil palmitat; ISOCETYL PALMITATE; SOCETL PALMTAT; ISOCETIL PALMITATE; isosetil palmitat; zosetl palmtate; IZOSETIL PALMITAT; Isocetyl palmitate; Hexadecanoic acid, isohexadecyl ester; UNII-355356620Z; 127770-27-8; 355356620Z; SCHEMBL5873231; DTXSID2074584; ZINC100096069; Q27256425; 127770-27-8 [RN]; 14-Methylpentadecyl palmitate [ACD/IUPAC Name]; 14-Methylpentadecylpalmitat [German] [ACD/IUPAC Name]; Hexadecanoic acid, 14-methylpentadecyl ester [ACD/Index Name]; ISOCETYL PALMITATE; Palmitate de 14-méthylpentadécyle [French] [ACD/IUPAC Name]; 14-METHYLPENTADECYL HEXADECANOATE; Hexadecanoic acid, isohexadecyl ester; zosetil palmitat; ISOCETYL PALMITATE; SOCETL PALMTAT; ISOCETIL PALMITATE; isosetil palmitat; zosetl palmtate; IZOSETIL PALMITAT; Isocetyl palmitate; Hexadecanoic acid, isohexadecyl ester; UNII-355356620Z; 127770-27-8; 355356620Z; SCHEMBL5873231; DTXSID2074584; ZINC100096069; Q27256425; 127770-27-8 [RN]; 14-Methylpentadecyl palmitate [ACD/IUPAC Name]; 14-Methylpentadecylpalmitat [German] [ACD/IUPAC Name]; Hexadecanoic acid, 14-methylpentadecyl ester [ACD/Index Name]; ISOCETYL PALMITATE; Palmitate de 14-méthylpentadécyle [French] [ACD/IUPAC Name]; 14-METHYLPENTADECYL HEXADECANOATE; Hexadecanoic acid, isohexadecyl ester; zosetil palmitat; ISOCETYL PALMITATE; SOCETL PALMTAT; ISOCETIL PALMITATE; isosetil palmitat; zosetl palmtate; IZOSETIL PALMITAT; Isocetyl palmitate; Hexadecanoic acid, isohexadecyl ester; UNII-355356620Z; 127770-27-8; 355356620Z; SCHEMBL5873231; DTXSID2074584; ZINC100096069; Q27256425; 127770-27-8 [RN]; 14-Methylpentadecyl palmitate [ACD/IUPAC Name]; 14-Methylpentadecylpalmitat [German] [ACD/IUPAC Name]; Hexadecanoic acid, 14-methylpentadecyl ester [ACD/Index Name]; ISOCETYL PALMITATE; Palmitate de 14-méthylpentadécyle [French] [ACD/IUPAC Name]; 14-METHYLPENTADECYL HEXADECANOATE; Hexadecanoic acid, isohexadecyl ester; zosetil palmitat; ISOCETYL PALMITATE; SOCETL PALMTAT; ISOCETIL PALMITATE; isosetil palmitat; zosetl palmtate; IZOSETIL PALMITAT; Isocetyl palmitate; Hexadecanoic acid, isohexadecyl ester; UNII-355356620Z; 127770-27-8; 355356620Z; SCHEMBL5873231; DTXSID2074584; ZINC100096069; Q27256425; 127770-27-8 [RN]; 14-Methylpentadecyl palmitate [ACD/IUPAC Name]; 14-Methylpentadecylpalmitat [German] [ACD/IUPAC Name]; Hexadecanoic acid, 14-methylpentadecyl ester [ACD/Index Name]; ISOCETYL PALMITATE; Palmitate de 14-méthylpentadécyle [French] [ACD/IUPAC Name]; 14-METHYLPENTADECYL HEXADECANOATE; Hexadecanoic acid, isohexadecyl ester; zosetil palmitat; ISOCETYL PALMITATE; SOCETL PALMTAT; ISOCETIL PALMITATE; isosetil palmitat; zosetl palmtate; IZOSETIL PALMITAT; Isocetyl palmitate; Hexadecanoic acid, isohexadecyl ester; UNII-355356620Z; 127770-27-8; 355356620Z; SCHEMBL5873231; DTXSID2074584; ZINC100096069; Q27256425; 127770-27-8 [RN]; 14-Methylpentadecyl palmitate [ACD/IUPAC Name]; 14-Methylpentadecylpalmitat [German] [ACD/IUPAC Name]; Hexadecanoic acid, 14-methylpentadecyl ester [ACD/Index Name]; ISOCETYL PALMITATE; Palmitate de 14-méthylpentadécyle [French] [ACD/IUPAC Name]; 14-METHYLPENTADECYL HEXADECANOATE; Hexadecanoic acid, isohexadecyl ester; zosetil palmitat; ISOCETYL PALMITATE; SOCETL PALMTAT; ISOCETIL PALMITATE; isosetil palmitat; zosetl palmtate; IZOSETIL PALMITAT; Isocetyl palmitate; Hexadecanoic acid, isohexadecyl ester; UNII-355356620Z; 127770-27-8; 355356620Z; SCHEMBL5873231; DTXSID2074584; ZINC100096069; Q27256425; 127770-27-8 [RN]; 14-Methylpentadecyl palmitate [ACD/IUPAC Name]; 14-Methylpentadecylpalmitat [German] [ACD/IUPAC Name]; Hexadecanoic acid, 14-methylpentadecyl ester [ACD/Index Name]; ISOCETYL PALMITATE; Palmitate de 14-méthylpentadécyle [French] [ACD/IUPAC Name]; 14-METHYLPENTADECYL HEXADECANOATE; Hexadecanoic acid, isohexadecyl ester; zosetil palmitat; ISOCETYL PALMITATE; SOCETL PALMTAT; ISOCETIL PALMITATE; isosetil palmitat; zosetl palmtate; IZOSETIL PALMITAT; Isocetyl palmitate; Hexadecanoic acid, isohexadecyl ester; UNII-355356620Z; 127770-27-8; 355356620Z; SCHEMBL5873231; DTXSID2074584; ZINC100096069; Q27256425; 127770-27-8 [RN]; 14-Methylpentadecyl palmitate [ACD/IUPAC Name]; 14-Methylpentadecylpalmitat [German] [ACD/IUPAC Name]; Hexadecanoic acid, 14-methylpentadecyl ester [ACD/Index Name]; ISOCETYL PALMITATE; Palmitate de 14-méthylpentadécyle [French] [ACD/IUPAC Name]; 14-METHYLPENTADECYL HEXADECANOATE; Hexadecanoic acid, isohexadecyl ester; zosetil palmitat; ISOCETYL PALMITATE; SOCETL PALMTAT; ISOCETIL PALMITATE; isosetil palmitat; zosetl palmtate; IZOSETIL PALMITAT;
EN
ISOCETYL PALMITATE (zosetil Palmitat) IUPAC Name 14-methylpentadecyl hexadecanoate
ISOCETYL PALMITATE (zosetil Palmitat) InChI InChI=1S/C32H64O2/c1-4-5-6-7-8-9-10-11-14-17-20-23-26-29-32(33)34-30-27-24-21-18-15-12-13-16-19-22-25-28-31(2)3/h31H,4-30H2,1-3H3
ISOCETYL PALMITATE (zosetil Palmitat) InChI Key OUZOBPPZPCBJAR-UHFFFAOYSA-N
ISOCETYL PALMITATE (zosetil Palmitat) Canonical SMILES CCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C
ISOCETYL PALMITATE (zosetil Palmitat) Molecular Formula C32H64O2
ISOCETYL PALMITATE (zosetil Palmitat) CAS 127770-27-8
ISOCETYL PALMITATE (zosetil Palmitat) UNII 355356620Z
ISOCETYL PALMITATE (zosetil Palmitat) DSSTox Substance ID DTXSID2074584
ISOCETYL PALMITATE (zosetil Palmitat) Related Compounds Similar Compounds 5,069 Records
ISOCETYL PALMITATE (zosetil Palmitat) Related Substances Same 18 Records
ISOCETYL PALMITATE (zosetil Palmitat) Use Classification Cosmetics -> Emollient; Skin conditioning
ISOCETYL PALMITATE (zosetil Palmitat) Molecular Weight 480.8 g/mol
ISOCETYL PALMITATE (zosetil Palmitat) XLogP3-AA 14.9
ISOCETYL PALMITATE (zosetil Palmitat) Hydrogen Bond Donor Count 0
ISOCETYL PALMITATE (zosetil Palmitat) Hydrogen Bond Acceptor Count 2
ISOCETYL PALMITATE (zosetil Palmitat) Rotatable Bond Count 29
ISOCETYL PALMITATE (zosetil Palmitat) Exact Mass 480.490631 g/mol
ISOCETYL PALMITATE (zosetil Palmitat) Monoisotopic Mass 480.490631 g/mol
ISOCETYL PALMITATE (zosetil Palmitat) Topological Polar Surface Area 26.3 Ų
ISOCETYL PALMITATE (zosetil Palmitat) Heavy Atom Count 34
ISOCETYL PALMITATE (zosetil Palmitat) Formal Charge 0
ISOCETYL PALMITATE (zosetil Palmitat) Complexity 391
ISOCETYL PALMITATE (zosetil Palmitat) Isotope Atom Count 0
ISOCETYL PALMITATE (zosetil Palmitat) Defined Atom Stereocenter Count 0
ISOCETYL PALMITATE (zosetil Palmitat) Undefined Atom Stereocenter Count 0
ISOCETYL PALMITATE (zosetil Palmitat) Defined Bond Stereocenter Count 0
ISOCETYL PALMITATE (zosetil Palmitat) Undefined Bond Stereocenter Count 0
ISOCETYL PALMITATE (zosetil Palmitat) Covalently-Bonded Unit Count 1
ISOCETYL PALMITATE (zosetil Palmitat) Compound Is Canonicalized Yes
ISOCETYL PALMITATE Properties Palmitic acid, or ISOCETYL PALMITATE (zosetil Palmitat) in IUPAC nomenclature, is the most common saturated fatty acid found in animals, plants and microorganisms.[9][10] Its chemical formula is CH3(CH2)14COOH, and its C:D is 16:0. As its name indicates, it is a major component of the oil from the fruit of oil palms (palm oil). Palmitic acid can also be found in meats, cheeses, butter, and other dairy products. Palmitates are the salts and esters of ISOCETYL PALMITATE (zosetil Palmitat). The palmitate anion is the observed form of ISOCETYL PALMITATE (zosetil Palmitat) at physiologic pH (7.4).Aluminium salts of ISOCETYL PALMITATE (zosetil Palmitat) and naphthenic acid were combined during World War II to produce napalm. The word “napalm” is derived from the words naphthenic acid and ISOCETYL PALMITATE (zosetil Palmitat).Palmitic acid was discovered by Edmond Frémy in 1840, in saponified palm oil.[11] This remains the primary industrial route for its production, with the triglycerides (fats) in palm oil being hydrolysed by high temperature water (above 200 °C or 390 °F), and the resulting mixture fractionally distilled to give the pure product.[12]Palmitic acid is naturally produced by a wide range of other plants and organisms, typically at low levels. It is naturally present in butter, cheese, milk, and meat, as well as cocoa butter, soybean oil, and sunflower oil. Karukas contain 44.90% ISOCETYL PALMITATE (zosetil Palmitat).[13] The cetyl ester of ISOCETYL PALMITATE (zosetil Palmitat) (cetyl palmitate) occurs in spermaceti.Excess carbohydrates in the body are converted to ISOCETYL PALMITATE (zosetil Palmitat). Palmitic acid is the first fatty acid produced during fatty acid synthesis and is the precursor to longer fatty acids. As a consequence, ISOCETYL PALMITATE (zosetil Palmitat) is a major body component of animals. In humans, one analysis found it to make up 21–30% (molar) of human depot fat,[14] and it is a major, but highly variable, lipid component of human breast milk.[15] Palmitate negatively feeds back on acetyl-CoA carboxylase (ACC), which is responsible for converting acetyl-CoA to malonyl-CoA, which in turn is used to add to the growing acyl chain, thus preventing further palmitate generation.[16] In biology, some proteins are modified by the addition of a palmitoyl group in a process known as palmitoylation. Palmitoylation is important for membrane localisation of many proteins.Palmitic acid is used to produce soaps, cosmetics, and industrial mold release agents. These applications use sodium palmitate, which is commonly obtained by saponification of palm oil. To this end, palm oil, rendered from palm tree (species Elaeis guineensis), is treated with sodium hydroxide (in the form of caustic soda or lye), which causes hydrolysis of the ester groups, yielding glycerol and sodium palmitate.Because it is inexpensive and adds texture and “mouth feel” to processed foods (convenience food), ISOCETYL PALMITATE (zosetil Palmitat) and its sodium salt find wide use in foodstuffs. Sodium palmitate is permitted as a natural additive in organic products.[17] The aluminium salt is used as a thickening agent of napalm used in military actions.Hydrogenation of ISOCETYL PALMITATE (zosetil Palmitat) yields cetyl alcohol, which is used to produce detergents and cosmetics.Recently, a long-acting antipsychotic medication, paliperidone palmitate (marketed as INVEGA Sustenna), used in the treatment of schizophrenia, has been synthesized using the oily palmitate ester as a long-acting release carrier medium when injected intramuscularly. The underlying method of drug delivery is similar to that used with decanoic acid to deliver long-acting depot medication, in particular, neuroleptics such as haloperidol decanoate.According to the World Health Organization, evidence is “convincing” that consumption of ISOCETYL PALMITATE (zosetil Palmitat) increases the risk of developing cardiovascular disease,[18] based on studies indicating that it may increase LDL levels in the blood. Retinyl palmitate is a source of vitamin A added to low-fat milk to replace the vitamin content lost through the removal of milk fat. Palmitate is attached to the alcohol form of vitamin A, retinol, to make vitamin A stable in milk.Treatment of commercially available 2-(decyl)dodecanoic acid or 2-(tetradecyl)ISOCETYL PALMITATE (zosetil Palmitat) (37) in methanol in the presence of concd sulfuric acid gave the methyl ester 38 in a quantitative yield. In the essentially same way, 3-(nonyl)dodecanoic acid or 3-(tridecyl)ISOCETYL PALMITATE (zosetil Palmitat) (40) gave the corresponding methyl esters 41 in almost quantitative yields. Reduction of the methyl esters with LiAlH4 in dry ether gave the corresponding alcohols 39 and 42 in good yields, respectively (Scheme 8).11The homologous series with n = 5 and m = 7 includes cis-9,10-methylene-hexadecanoic acid, and the homologous series with n = 5 and m = 9 includes lactobacillic acid (cis-11,12-methylene-octadecanoic acid). The homologous series with n = 7 and m = 6 includes dihydromalvalic acid (systematic name: 2-octyl-cyclopropaneheptanoic acid), and the homologous series with n = 7 and m = 7 includes dihydrosterculic acid (systematic name: cis-9,10-methylene-octadecanoic acid), see Fig. 6.Experimental Hf data (Table A3) in the range of n-heptanoic acid (nC= 7) and ISOCETYL PALMITATE (zosetil Palmitat) (nC= 16) were used as the training set for deriving a QPPR of the form of Eq. 3 for the n-alkanoic acid series. The uncertainty level for the data ranges between <0.2% to <3%. The resultant parameter values obtained: B0= (3.461 ± 0.076) × 107 and B1= 1.005525 ± 0.026 with a correlation coefficient R2= 0.998967 and a randomly distributed residual plot (Fig. A3). As in the case of the n-mercaptans, the value of B1 is essentially 1.Essential oils are principal components of the leaves of fenugreek with main compounds as (2E)-hexenal (26.61%), ISOCETYL PALMITATE (zosetil Palmitat) (10.14%) and (E)-β-ionone (7.99%) among others (Riasat et al., 2017). These fragrant molecules are however not the major constituent of the seeds and are not herein addressed as the pharmacologically relevant constituents. In one particular analysis study by Shahinuzzaman et al. (2015), the essential oil constituents of fenugreek seeds were shown to contain fatty acids as major components: decane, 5,6-bis(2,2-dimethylpropylidene)-, (E,Z)- (19.58%), ISOCETYL PALMITATE (zosetil Palmitat), methyl ester (18.81%) and dihydro methyl jasmonate (10.99%) (Table 17.1). Hence fatty acids and derivatives are the major essential oil components of fenugreek seeds.The content of essential oils of Centaurea species are characterized by the presence of sesquiterpenes skeleton (caryophyllene, eudesmol and germacrene); hydracarbons (tricosane, pentacosane and heptacosane); fatty acids (ISOCETYL PALMITATE (zosetil Palmitat), tetradecanoic acid, and dodecanoic acid) and monoterpenes (aspinene, terpinene and carvacrol) [72–74].Common names of fatty acids are more often used than the IUPAC names (Table 31.1). The most common saturated fatty acids, palmitic and stearic acids, contain 16 and 18 carbon atoms, respectively. Their IUPAC names are ISOCETYL PALMITATE (zosetil Palmitat) and octadecanoic acid, respectively.The aromatics and their derivatives such as benzene, methylbenzene, and phenol, fatty acids such as a ISOCETYL PALMITATE (zosetil Palmitat), nitrogen-containing compounds such as amines and amides, and other group alcohols, aldehydes, and ketones were oxygen-containing compounds.DL in ethanol-water cosolvent (EWCS) were more dispersive, and their relative content were lower than 10%, except for ISOCETYL PALMITATE (zosetil Palmitat) ethyl ester with its relative content of 15.06%. Typically, the content of ISOCETYL PALMITATE (zosetil Palmitat) produced in HTL reached 17.27% but decreased to 9.79% in EWCS and 3.21% in pure ethanol, while the ISOCETYL PALMITATE (zosetil Palmitat) ethyl ester content increased from 0% in HTL to 15.06% in EWCS, and then up to 38.4% in pure ethanol. Furthermore, the other ethyl esters such as 5,8,11,14-eicosatetraenoic acid, ethyl ester, (all-Z)- and ethyl linoleate were also higher in bio-oil from EWCS and pure ethanol. This indicated that the addition of ethanol into liquefaction system could serve as a substrate, reacting with acidic components like ISOCETYL PALMITATE (zosetil Palmitat) and obtaining corresponding esters like ISOCETYL PALMITATE (zosetil Palmitat) ethyl ester, which is known as etherification. Biswas et al. [41] observed from GS-MS of Sargassum tenerrimum algae-derived bio-oil using water as a solvent for HTL at 280°C (STW280) were 3-pyridiol, p-hydroxybiphenyl, ISOCETYL PALMITATE (zosetil Palmitat), bis(2-ethylhexyl) phthalate, stigmastan-3,5-diene, and hexadecanamide. For C2H5OH as the solvent (ST-E280) the main compounds were ISOCETYL PALMITATE (zosetil Palmitat)-ethyl ester, ethyl oleate, tetradecanoic acid-ethyl ester, and isosorbide. Hexadecanoic acid-methyl ester, methyl tetradecanoate, 8-octadecenoic acid methyl ester, and methyl hexadec-9-enoate were the compounds found in major concentrations in bio-oil obtained.This compound, composed of cyclic phosphate and cyclopropane-containing ISOCETYL PALMITATE (zosetil Palmitat), inhibited more than 80% of the affinity-purified calf thymus DNA polymerase α activity at a concentration of 10 μg/mL.Preparation of one diastereomer of cyclopropane-containing ISOCETYL PALMITATE (zosetil Palmitat) (81) was summarized in Scheme 7, starting with enzymatic hydrolysis of meso diester (74).Palmitic Acid Palmitic acid (also known as ISOCETYL PALMITATE (zosetil Palmitat)) is a fatty acid that is found naturally in animals and plants and also can be created in laboratory settings. Palmitic acid is widely used in a variety of applications, including personal care products and cosmetics.Palmitic acid (ISOCETYL PALMITATE (zosetil Palmitat)) has been for long time negatively depicted for its putative detrimental health effects, shadowing its multiple crucial physiological activities. ISOCETYL PALMITATE (zosetil Palmitat) is the most common saturated fatty acid accounting for 20–30% of total fatty acids in the human body and can be provided in the diet or synthesized endogenously via de novo lipogenesis (DNL). ISOCETYL PALMITATE (zosetil Palmitat) tissue content seems to be controlled around a well-defined concentration, and changes in its intake do not influence significantly its tissue concentration because the exogenous source is counterbalanced by ISOCETYL PALMITATE (zosetil Palmitat) endogenous biosynthesis. Particular physiopathological conditions and nutritional factors may strongly induce DNL, resulting in increased tissue content of ISOCETYL PALMITATE (zosetil Palmitat) and disrupted homeostatic control of its tissue concentration. The tight homeostatic control of ISOCETYL PALMITATE (zosetil Palmitat) tissue concentration is likely related to its fundamental physiological role to guarantee membrane physical properties but also to consent protein palmitoylation, palmitoylethanolamide (PEA) biosynthesis, and in the lung an efficient surfactant activity. In order to maintain membrane phospholipids (PL) balance may be crucial an optimal intake of ISOCETYL PALMITATE (zosetil Palmitat) in a certain ratio with unsaturated fatty acids, especially PUFAs of both n-6 and n-3 families. However, in presence of other factors such as positive energy balance, excessive intake of carbohydrates (in particular mono and disaccharides), and a sedentary lifestyle, the mechanisms to maintain a steady state of ISOCETYL PALMITATE (zosetil Palmitat) concentration may be disrupted leading to an over accumulation of tissue ISOCETYL PALMITATE (zosetil Palmitat) resulting in dyslipidemia, hyperglycemia, increased ectopic fat accumulation and increased inflammatory tone via toll-like receptor 4. It is therefore likely that the controversial data on the association of dietary ISOCETYL PALMITATE (zosetil Palmitat) with detrimental health effects, may be related to an excessive imbalance of dietary ISOCETYL PALMITATE (zosetil Palmitat)/PUFA ratio which, in certain physiopathological conditions, and in presence of an enhanced DNL, may further accelerate these deleterious effects.Palmitic acid (16:0, ISOCETYL PALMITATE (zosetil Palmitat)) is the most common saturated fatty acid found in the human body and can be provided in the diet or synthesized endogenously from other fatty acids, carbohydrates and amino acids.n average, a 70-kg man is made up of 3.5 Kg of ISOCETYL PALMITATE (zosetil Palmitat). As the name suggests, ISOCETYL PALMITATE (zosetil Palmitat) is a major component of palm oil (44% of total fats), but significant amounts of ISOCETYL PALMITATE (zosetil Palmitat) can also be found in meat and dairy products (50–60% of total fats), as well as cocoa butter (26%) and olive oil (8–20%). Furthermore, ISOCETYL PALMITATE (zosetil Palmitat) is present in breast milk with 20–30% of total fats.The tight homeostatic control of ISOCETYL PALMITATE (zosetil Palmitat) tissue concentration is likely related to its fundamental physiological role in several biological functions. Particularly in infants ISOCETYL PALMITATE (zosetil Palmitat) seems to play a crucial role as recently thoroughly revised by Innis (Innis, 2016). The disruption of ISOCETYL PALMITATE (zosetil Palmitat) homeostatic balance, implicated in different physiopathological conditions such as atherosclerosis, neurodegenerative diseases and cancer, is often related to an uncontrolled ISOCETYL PALMITATE (zosetil Palmitat) endogenous biosynthesis, irrespective of its dietary contribution.FA synthesis starts with citrate conversion to acetyl-CoA and then malonyl-CoA, which is then elongated to form palmitate and other FA. Key enzymes in this process are acetyl-CoA carboxylase (ACC), which catalyzes the DNL limiting step reaction, and the FA synthase (FAS). The main sources of citrate for DNL are glucose and glutamine-derived α-ketoglutarate (α-KG), especially under hypoxia or disruption of the mitochondrial oxidative machinery.Palmitic acid, or ISOCETYL PALMITATE (zosetil Palmitat), is one of the most common saturated fatty acids found in animals, plants, and microorganisms.Palmitic acid is used to produce soaps, cosmetics, and industrial mould release agents.Palmitic acid is also used in the determination of water hardness and is a surfactant of Levovist, an intravenous ultrasonic contrast agent.Palmitic acid, or ISOCETYL PALMITATE (zosetil Palmitat) in IUPAC nomenclature, is the most common saturated fatty acid found in animals, plants and microorganisms.[9][10] Its chemical formula is CH3(CH2)14COOH, and its C:D is 16:0. As its name indicates, it is a major component of the oil from the fruit of oil palms (palm oil). Palmitic acid can also be found in meats, cheeses, butter, and other dairy products. Palmitates are the salts and esters of ISOCETYL PALMITATE (zosetil Palmitat). The palmitate anion is the observed form of ISOCETYL PALMITATE (zosetil Palmitat) at physiologic pH (7.4).Aluminium salts of ISOCETYL PALMITATE (zosetil Palmitat) and naphthenic acid were combined during World War II to produce napalm. The word “napalm” is derived from the words naphthenic acid and ISOCETYL PALMITATE (zosetil Palmitat).Palmitic acid was discovered by Edmond Frémy in 1840, in saponified palm oil.[11] This remains the primary industrial route for its production, with the triglycerides (fats) in palm oil being hydrolysed by high temperature water (above 200 °C or 390 °F), and the resulting mixture fractionally distilled to give the pure product.[12]Palmitic acid is naturally produced by a wide range of other plants and organisms, typically at low levels. It is naturally present in butter, cheese, milk, and meat, as well as cocoa butter, soybean oil, and sunflower oil. Karukas contain 44.90% ISOCETYL PALMITATE (zosetil Palmitat).[13] The cetyl ester of ISOCETYL PALMITATE (zosetil Palmitat) (cetyl palmitate) occurs in spermaceti.ISOCETYL PALMITATE Properties Palmitic acid, or ISOCETYL PALMITATE (zosetil Palmitat) in IUPAC nomenclature, is the most common saturated fatty acid found in animals, plants and microorganisms.[9][10] Its chemical formula is CH3(CH2)14COOH, and its C:D is 16:0. As its name indicates, it is a major component of the oil from the fruit of oil palms (palm oil). Palmitic acid can also be found in meats, cheeses, butter, and other dairy products. Palmitates are the salts and esters of ISOCETYL PALMITATE (zosetil Palmitat). The palmitate anion is the observed form of ISOCETYL PALMITATE (zosetil Palmitat) at physiologic pH (7.4).Aluminium salts of ISOCETYL PALMITATE (zosetil Palmitat) and naphthenic acid were combined during World War II to produce napalm. The word “napalm” is derived from the words naphthenic acid and ISOCETYL PALMITATE (zosetil Palmitat).Palmitic acid was discovered by Edmond Frémy in 1840, in saponified palm oil.[11] This remains the primary industrial route for its production, with the triglycerides (fats) in palm oil being hydrolysed by high temperature water (above 200 °C or 390 °F), and the resulting mixture fractionally distilled to give the pure product.[12]Palmitic acid is naturally produced by a wide range of other plants and organisms, typically at low levels. It is naturally present in butter, cheese, milk, and meat, as well as cocoa butter, soybean oil, and sunflower oil. Karukas contain 44.90% ISOCETYL PALMITATE (zosetil Palmitat).[13] The cetyl ester of ISOCETYL PALMITATE (zosetil Palmitat) (cetyl palmitate) occurs in spermaceti.Excess carbohydrates in the body are converted to ISOCETYL PALMITATE (zosetil Palmitat). Palmitic acid is the first fatty acid produced during fatty acid synthesis and is the precursor to longer fatty acids. As a consequence, ISOCETYL PALMITATE (zosetil Palmitat) is a major body component of animals. In humans, one analysis found it to make up 21–30% (molar) of human depot fat,[14] and it is a major, but highly variable, lipid component of human breast milk.[15] Palmitate negatively feeds back on acetyl-CoA carboxylase (ACC), which is responsible for converting acetyl-CoA to malonyl-CoA, which in turn is used to add to the growing acyl chain, thus preventing further palmitate generation.[16] In biology, some proteins are modified by the addition of a palmitoyl group in a process known as palmitoylation. Palmitoylation is important for membrane localisation of many proteins.Palmitic acid is used to produce soaps, cosmetics, and industrial mold release agents. These applications use sodium palmitate, which is commonly obtained by saponification of palm oil. To this end, palm oil, rendered from palm tree (species Elaeis guineensis), is treated with sodium hydroxide (in the form of caustic soda or lye), which causes hydrolysis of the ester groups, yielding glycerol and sodium palmitate.Because it is inexpensive and adds texture and “mouth feel” to processed foods (convenience food), ISOCETYL PALMITATE (zosetil Palmitat) and its sodium salt find wide use in foodstuffs. Sodium palmitate is permitted as a natural additive in organic products.[17] The aluminium salt is used as a thickening agent of napalm used in military actions.Hydrogenation of ISOCETYL PALMITATE (zosetil Palmitat) yields cetyl alcohol, which is used to produce detergents and cosmetics.Recently, a long-acting antipsychotic medication, paliperidone palmitate (marketed as INVEGA Sustenna), used in the treatment of schizophrenia, has been synthesized using the oily palmitate ester as a long-acting release carrier medium when injected intramuscularly. The underlying method of drug delivery is similar to that used with decanoic acid to deliver long-acting depot medication, in particular, neuroleptics such as haloperidol decanoate.According to the World Health Organization, evidence is “convincing” that consumption of ISOCETYL PALMITATE (zosetil Palmitat) increases the risk of developing cardiovascular disease,[18] based on studies indicating that it may increase LDL levels in the blood. Retinyl palmitate is a source of vitamin A added to low-fat milk to replace the vitamin content lost through the removal of milk fat. Palmitate is attached to the alcohol form of vitamin A, retinol, to make vitamin A stable in milk.Treatment of commercially available 2-(decyl)dodecanoic acid or 2-(tetradecyl)ISOCETYL PALMITATE (zosetil Palmitat) (37) in methanol in the presence of concd sulfuric acid gave the methyl ester 38 in a quantitative yield. In the essentially same way, 3-(nonyl)dodecanoic acid or 3-(tridecyl)ISOCETYL PALMITATE (zosetil Palmitat) (40) gave the corresponding methyl esters 41 in almost quantitative yields. Reduction of the methyl esters with LiAlH4 in dry ether gave the corresponding alcohols 39 and 42 in good yields, respectively (Scheme 8).11The homologous series with n = 5 and m = 7 includes cis-9,10-methylene-hexadecanoic acid, and the homologous series with n = 5 and m = 9 includes lactobacillic acid (cis-11,12-methylene-octadecanoic acid). The homologous series with n = 7 and m = 6 includes dihydromalvalic acid (systematic name: 2-octyl-cyclopropaneheptanoic acid), and the homologous series with n = 7 and m = 7 includes dihydrosterculic acid (systematic name: cis-9,10-methylene-octadecanoic acid), see Fig. 6.Experimental Hf data (Table A3) in the range of n-heptanoic acid (nC= 7) and ISOCETYL PALMITATE (zosetil Palmitat) (nC= 16) were used as the training set for deriving a QPPR of the form of Eq. 3 for the n-alkanoic acid series. The uncertainty level for the data ranges between <0.2% to <3%. The resultant parameter values obtained: B0= (3.461 ± 0.076) × 107 and B1= 1.005525 ± 0.026 with a correlation coefficient R2= 0.998967 and a randomly distributed residual plot (Fig. A3). As in the case of the n-mercaptans, the value of B1 is essentially 1.Essential oils are principal components of the leaves of fenugreek with main compounds as (2E)-hexenal (26.61%), ISOCETYL PALMITATE (zosetil Palmitat) (10.14%) and (E)-β-ionone (7.99%) among others (Riasat et al., 2017). These fragrant molecules are however not the major constituent of the seeds and are not herein addressed as the pharmacologically relevant constituents. In one particular analysis study by Shahinuzzaman et al. (2015), the essential oil constituents of fenugreek seeds were shown to contain fatty acids as major components: decane, 5,6-bis(2,2-dimethylpropylidene)-, (E,Z)- (19.58%), ISOCETYL PALMITATE (zosetil Palmitat), methyl ester (18.81%) and dihydro methyl jasmonate (10.99%) (Table 17.1). Hence fatty acids and derivatives are the major essential oil components of fenugreek seeds.The content of essential oils of Centaurea species are characterized by the presence of sesquiterpenes skeleton (caryophyllene, eudesmol and germacrene); hydracarbons (tricosane, pentacosane and heptacosane); fatty acids (ISOCETYL PALMITATE (zosetil Palmitat), tetradecanoic acid, and dodecanoic acid) and monoterpenes (aspinene, terpinene and carvacrol) [72–74].Common names of fatty acids are more often used than the IUPAC names (Table 31.1). The most common saturated fatty acids, palmitic and stearic acids, contain 16 and 18 carbon atoms, respectively. Their IUPAC names are ISOCETYL PALMITATE (zosetil Palmitat) and octadecanoic acid, respectively.The aromatics and their derivatives such as benzene, methylbenzene, and phenol, fatty acids such as a ISOCETYL PALMITATE (zosetil Palmitat), nitrogen-containing compounds such as amines and amides, and other group alcohols, aldehydes, and ketones were oxygen-containing compounds.DL in ethanol-water cosolvent (EWCS) were more dispersive, and their relative content were lower than 10%, except for ISOCETYL PALMITATE (zosetil Palmitat) ethyl ester with its relative content of 15.06%. Typically, the content of ISOCETYL PALMITATE (zosetil Palmitat) produced in HTL reached 17.27% but decreased to 9.79% in EWCS and 3.21% in pure ethanol, while the ISOCETYL PALMITATE (zosetil Palmitat) ethyl ester content increased from 0% in HTL to 15.06% in EWCS, and then up to 38.4% in pure ethanol. Furthermore, the other ethyl esters such as 5,8,11,14-eicosatetraenoic acid, ethyl ester, (all-Z)- and ethyl linoleate were also higher in bio-oil from EWCS and pure ethanol. This indicated that the addition of ethanol into liquefaction system could serve as a substrate, reacting with acidic components like ISOCETYL PALMITATE (zosetil Palmitat) and obtaining corresponding esters like ISOCETYL PALMITATE (zosetil Palmitat) ethyl ester, which is known as etherification. Biswas et al. [41] observed from GS-MS of Sargassum tenerrimum algae-derived bio-oil using water as a solvent for HTL at 280°C (STW280) were 3-pyridiol, p-hydroxybiphenyl, ISOCETYL PALMITATE (zosetil Palmitat), bis(2-ethylhexyl) phthalate, stigmastan-3,5-diene, and hexadecanamide. For C2H5OH as the solvent (ST-E280) the main compounds were ISOCETYL PALMITATE (zosetil Palmitat)-ethyl ester, ethyl oleate, tetradecanoic acid-ethyl ester, and isosorbide. Hexadecanoic acid-methyl ester, methyl tetradecanoate, 8-octadecenoic acid methyl ester, and methyl hexadec-9-enoate were the compounds found in major concentrations in bio-oil obtained.This compound, composed of cyclic phosphate and cyclopropane-containing ISOCETYL PALMITATE (zosetil Palmitat), inhibited more than 80% of the affinity-purified calf thymus DNA polymerase α activity at a concentration of 10 μg/mL.Preparation of one diastereomer of cyclopropane-containing ISOCETYL PALMITATE (zosetil Palmitat) (81) was summarized in Scheme 7, starting with enzymatic hydrolysis of meso diester (74).Palmitic Acid Palmitic acid (also known as ISOCETYL PALMITATE (zosetil Palmitat)) is a fatty acid that is found naturally in animals and plants and also can be created in laboratory settings. Palmitic acid is widely used in a variety of applications, including personal care products and cosmetics.Palmitic acid (ISOCETYL PALMITATE (zosetil Palmitat)) has been for long time negatively depicted for its putative detrimental health effects, shadowing its multiple crucial physiological activities. ISOCETYL PALMITATE (zosetil Palmitat) is the most common saturated fatty acid accounting for 20–30% of total fatty acids in the human body and can be provided in the diet or synthesized endogenously via de novo lipogenesis (DNL). ISOCETYL PALMITATE (zosetil Palmitat) tissue content seems to be controlled around a well-defined concentration, and changes in its intake do not influence significantly its tissue concentration because the exogenous source is counterbalanced by ISOCETYL PALMITATE (zosetil Palmitat) endogenous biosynthesis. Particular physiopathological conditions and nutritional factors may strongly induce DNL, resulting in increased tissue content of ISOCETYL PALMITATE (zosetil Palmitat) and disrupted homeostatic control of its tissue concentration. The tight homeostatic control of ISOCETYL PALMITATE (zosetil Palmitat) tissue concentration is likely related to its fundamental physiological role to guarantee membrane physical properties but also to consent protein palmitoylation, palmitoylethanolamide (PEA) biosynthesis, and in the lung an efficient surfactant activity. In order to maintain membrane phospholipids (PL) balance may be crucial an optimal intake of ISOCETYL PALMITATE (zosetil Palmitat) in a certain ratio with unsaturated fatty acids, especially PUFAs of both n-6 and n-3 families. However, in presence of other factors such as positive energy balance, excessive intake of carbohydrates (in particular mono and disaccharides), and a sedentary lifestyle, the mechanisms to maintain a steady state of ISOCETYL PALMITATE (zosetil Palmitat) concentration may be disrupted leading to an over accumulation of tissue ISOCETYL PALMITATE (zosetil Palmitat) resulting in dyslipidemia, hyperglycemia, increased ectopic fat accumulation and increased inflammatory tone via toll-like receptor 4. It is therefore likely that the controversial data on the association of dietary ISOCETYL PALMITATE (zosetil Palmitat) with detrimental health effects, may be related to an excessive imbalance of dietary ISOCETYL PALMITATE (zosetil Palmitat)/PUFA ratio which, in certain physiopathological conditions, and in presence of an enhanced DNL, may further accelerate these deleterious effects.Palmitic acid (16:0, ISOCETYL PALMITATE (zosetil Palmitat)) is the most common saturated fatty acid found in the human body and can be provided in the diet or synthesized endogenously from other fatty acids, carbohydrates and amino acids.n average, a 70-kg man is made up of 3.5 Kg of ISOCETYL PALMITATE (zosetil Palmitat). As the name suggests, ISOCETYL PALMITATE (zosetil Palmitat) is a major component of palm oil (44% of total fats), but significant amounts of ISOCETYL PALMITATE (zosetil Palmitat) can also be found in meat and dairy products (50–60% of total fats), as well as cocoa butter (26%) and olive oil (8–20%). Furthermore, ISOCETYL PALMITATE (zosetil Palmitat) is present in breast milk with 20–30% of total fats.The tight homeostatic control of ISOCETYL PALMITATE (zosetil Palmitat) tissue concentration is likely related to its fundamental physiological role in several biological functions. Particularly in infants ISOCETYL PALMITATE (zosetil Palmitat) seems to play a crucial role as recently thoroughly revised by Innis (Innis, 2016). The disruption of ISOCETYL PALMITATE (zosetil Palmitat) homeostatic balance, implicated in different physiopathological conditions such as atherosclerosis, neurodegenerative diseases and cancer, is often related to an uncontrolled ISOCETYL PALMITATE (zosetil Palmitat) endogenous biosynthesis, irrespective of its dietary contribution.FA synthesis starts with citrate conversion to acetyl-CoA and then malonyl-CoA, which is then elongated to form palmitate and other FA. Key enzymes in this process are acetyl-CoA carboxylase (ACC), which catalyzes the DNL limiting step reaction, and the FA synthase (FAS). The main sources of citrate for DNL are glucose and glutamine-derived α-ketoglutarate (α-KG), especially under hypoxia or disruption of the mitochondrial oxidative machinery.Palmitic acid, or ISOCETYL PALMITATE (zosetil Palmitat), is one of the most common saturated fatty acids found in animals, plants, and microorganisms.Palmitic acid is used to produce soaps, cosmetics, and industrial mould release agents.Palmitic acid is also used in the determination of water hardness and is a surfactant of Levovist, an intravenous ultrasonic contrast agent.Palmitic acid, or ISOCETYL PALMITATE (zosetil Palmitat) in IUPAC nomenclature, is the most common saturated fatty acid found in animals, plants and microorganisms.[9][10] Its chemical formula is CH3(CH2)14COOH, and its C:D is 16:0. As its name indicates, it is a major component of the oil from the fruit of oil palms (palm oil). Palmitic acid can also be found in meats, cheeses, butter, and other dairy products. Palmitates are the salts and esters of ISOCETYL PALMITATE (zosetil Palmitat). The palmitate anion is the observed form of ISOCETYL PALMITATE (zosetil Palmitat) at physiologic pH (7.4).Aluminium salts of ISOCETYL PALMITATE (zosetil Palmitat) and naphthenic acid were combined during World War II to produce napalm. The word “napalm” is derived from the words naphthenic acid and ISOCETYL PALMITATE (zosetil Palmitat).Palmitic acid was discovered by Edmond Frémy in 1840, in saponified palm oil.[11] This remains the primary industrial route for its production, with the triglycerides (fats) in palm oil being hydrolysed by high temperature water (above 200 °C or 390 °F), and the resulting mixture fractionally distilled to give the pure product.[12]Palmitic acid is naturally produced by a wide range of other plants and organisms, typically at low levels. It is naturally present in butter, cheese, milk, and meat, as well as cocoa butter, soybean oil, and sunflower oil. Karukas contain 44.90% ISOCETYL PALMITATE (zosetil Palmitat).[13] The cetyl ester of ISOCETYL PALMITATE (zosetil Palmitat) (cetyl palmitate) occurs in spermaceti.
TR
ISOCETYL PALMITATE (zosetil Palmitat) IUPAC Ad 14-metilpentadesil hekzadekanoat
ISOCETYL PALMITATE (zosetil Palmitat) InChI InChI = 1S / C32H64O2 / c1-4-5-6-7-8-9-10-11-14-17-20-23-26-29-32 (33) 34-30-27-24-21 -18-15-12-13-16-19-22-25-28-31 (2) 3 / h31H, 4-30H2,1-3H3
ISOCETYL PALMITATE (zosetil Palmitat) InChI Anahtar OUZOBPPZPCBJAR-UHFFFAOYSA-N
ISOCETYL PALMITATE (zosetil Palmitat) Kanonik SMILES CCCCCCCCCCCCCCCC (= O) OCCCCCCCCCCCCCC (C) C
ISOCETYL PALMITATE (zosetil Palmitat) Moleküler Formül C32H64O2
ISOCETYL PALMITATE (zosetil Palmitat) CAS 127770-27-8
ISOCETYL PALMITATE (zosetil Palmitat) UNII 355356620Z
ISOCETYL PALMITATE (zosetil Palmitat) DSSTox Madde Kimlii DTXSID2074584
ISOCETYL PALMITATE (zosetil Palmitat) lgili Bileikler Benzer Bileikler 5.069 Kayt
ISOCETYL PALMITATE (zosetil Palmitat) lgili Maddeler Ayn 18 Kayt
ISOCETYL PALMITATE (zosetil Palmitat) Kullanm Snflandrmas Kozmetik -> Yumuatc; Cilt bakm
ISOCETYL PALMITATE (zosetil Palmitat) Moleküler Arlk 480,8 g / mol
ISOCETYL PALMITATE (zosetil Palmitat) XLogP3-AA 14.9
ISOCETYL PALMITATE (zosetil Palmitat) Hidrojen Ba Donör Says 0
ISOCETYL PALMITATE (zosetil Palmitat) Hidrojen Ba Alcs Says 2
ISOCETYL PALMITATE (zosetil Palmitat) Dönebilen Tahvil Says 29
ISOCETYL PALMITATE (zosetil Palmitat) Tam Kütle 480.490631 g / mol
ISOCETYL PALMITATE (zosetil Palmitat) Monoizotopik Kütle 480.490631 g / mol
ISOCETYL PALMITATE (zosetil Palmitat) Topolojik Polar Yüzey Alan 26,3 Ų
ISOCETYL PALMITATE (zosetil Palmitat) Ar Atom Says 34
ISOCETYL PALMITATE (zosetil Palmitat) Resmi Ücret 0
ISOCETYL PALMITATE (zosetil Palmitat) Karmaklk 391
ISOCETYL PALMITATE (zosetil Palmitat) zotop Atom Says 0
ISOCETYL PALMITATE (zosetil Palmitat) Tanml Atom Stereo Merkez Says 0
ISOCETYL PALMITATE (zosetil Palmitat) Tanmsz Atom Stereo Merkez Says 0
ISOCETYL PALMITATE (zosetil Palmitat) Tanml Bond Stereocenter Says 0
ISOCETYL PALMITATE (zosetil Palmitat) Tanmsz Ba Stereocenter Says 0
ISOCETYL PALMITATE (zosetil Palmitat) Kovalent Bal Birim Says 1
ISOCETYL PALMITATE (zosetil Palmitat) Bileik Kanonikletirilmitir Evet
ISOCETYL PALMITATE (zosetil Palmitat) Özellikler ISOCETYL PALMITATE (zosetil Palmitat) veya IUPAC adlandrmasndaki heksadekanoik asit, hayvanlarda, bitkilerde ve mikroorganizmalarda bulunan en yaygn doymu ya asididir. [9] [10] Kimyasal formülü CH3 (CH2) 14COOH ve C: D 16: 0’dr. Adndan da anlalaca gibi, palmiye ya (palmiye ya) meyvesinden elde edilen yan önemli bir bileenidir. ISOCETYL PALMITATE (zosetil Palmitat) ayrca etlerde, peynirlerde, tereyanda ve dier süt ürünlerinde bulunabilir. Palmitatlar, ISOCETYL PALMITATE (zosetil Palmitat) tuzlar ve esterleridir. Palmitat anyonu, fizyolojik pH’ta (7.4) gözlenen ISOCETYL PALMITATE (zosetil Palmitat) formudur. ISOCETYL PALMITATE (zosetil Palmitat) ve naftenik asidin alüminyum tuzlar, napalm üretmek için II.Dünya Sava srasnda birletirildi. “Napalm” kelimesi naftenik asit ve ISOCETYL PALMITATE (zosetil Palmitat) kelimelerinden türetilmitir. ISOCETYL PALMITATE (zosetil Palmitat), 1840 ylnda Edmond Frémy tarafndan sabunlatrlm hurma yanda kefedilmitir. [11] Hurma yandaki trigliseridlerin (yalar) yüksek scaklktaki suyla (200 ° C veya 390 ° F’nin üzerinde) hidrolize edilmesi ve elde edilen karmn saf ürünü vermek üzere fraksiyonel olarak damtlmasyla bu, üretimi için birincil endüstriyel yol olmaya devam ediyor. [12 ] ISOCETYL PALMITATE (zosetil Palmitat), tipik olarak düük seviyelerde, çok çeitli baka bitkiler ve organizmalar tarafndan doal olarak üretilir. Tereya, peynir, süt ve etin yan sra kakao ya, soya fasulyesi ya ve ayçiçek yanda doal olarak bulunur. Karukas% 44.90 ISOCETYL PALMITATE (zosetil Palmitat) içerir. [13] ISOCETYL PALMITATE (zosetil Palmitat) setil esteri (setil palmitat), spermasette oluur ve vücuttaki fazla karbonhidrat ISOCETYL PALMITATE (zosetil Palmitat) dönütürülür. ISOCETYL PALMITATE (zosetil Palmitat), ya asidi sentezi srasnda üretilen ilk ya asididir ve daha uzun ya asitlerinin öncüsüdür. Sonuç olarak, ISOCETYL PALMITATE (zosetil Palmitat), hayvanlarn ana vücut bileenidir. nsanlarda, bir analiz, insan deposu yann% 21-30’unu (molar) oluturduunu buldu [14] ve anne sütünün önemli, ancak oldukça deiken bir lipid bileenidir. [15] Palmitat, asetil-CoA’y malonil-CoA’ya dönütürmekten sorumlu olan asetil-CoA karboksilaz (ACC) negatif olarak geri besler, bu da büyüyen asil zincirine eklenmek için kullanlr ve böylece daha fazla palmitat oluumunu önler.[16] Biyolojide, baz proteinler, palmitoilasyon olarak bilinen bir süreçte bir palmitoil grubunun eklenmesiyle modifiye edilir. Palmitoilasyon, birçok proteinin membran lokalizasyonu için önemlidir.ISOCETYL PALMITATE (zosetil Palmitat), sabunlar, kozmetikler ve endüstriyel kalp ayrc ajanlar üretmek için kullanlr. Bu uygulamalarda, genellikle hurma yann sabunlatrlmasyla elde edilen sodyum palmitat kullanlr. Bu amaçla, palmiye aacndan (Elaeis guineensis türü) elde edilen hurma ya, ester gruplarnn hidrolizine neden olarak gliserol ve sodyum palmitat veren sodyum hidroksit (kostik soda veya kül suyu formunda) ile ilenir. ucuzdur ve ilenmi gdalara (hazr gda) doku ve “az hissi” katar, ISOCETYL PALMITATE (zosetil Palmitat) ve sodyum tuzu, gda maddelerinde geni kullanm alan bulur. Organik ürünlerde doal katk maddesi olarak sodyum palmitata izin verilmektedir. [17] Alüminyum tuzu, askeri eylemlerde kullanlan napalm kalnlatrc bir madde olarak kullanlr.ISOCETYL PALMITATE (zosetil Palmitat) hidrojenasyonu, deterjan ve kozmetik üretiminde kullanlan setil alkolü verir. Son zamanlarda, uzun etkili bir antipsikotik ilaç olan paliperidon palmitat (INVEGA Sustenna olarak pazarlanmaktadr) izofreni tedavisinde kullanlan, kas içine enjekte edildiinde uzun etkili salm tayc ortam olarak yal palmitat ester kullanlarak sentezlenmitir. Altta yatan ilaç verme yöntemi, özellikle haloperidol dekanoat gibi nöroleptikler gibi uzun etkili depo ilaçlarnn verilmesi için dekanoik asitle kullanlana benzerdir.Dünya Salk Örgütü’ne göre, kantlar, ISOCETYL PALMITATE (zosetil Palmitat) tüketiminin arttn “ikna edicidir”. kardiyovasküler hastalk gelitirme riski [18], kandaki LDL düzeylerini artrabileceini gösteren çalmalara dayanmaktadr. Retinil palmitat, süt yann çkarlmasyla kaybedilen vitamin içeriinin yerini almas için az yal süte eklenen bir A vitamini kaynadr. Palmitat, sütte A vitamini stabil hale getirmek için A vitamini, retinol alkol formuna balanr.Ticari olarak temin edilebilen 2- (desil) dodesanoik asit veya 2- (tetradesil) hekzadekanoik asit (37), metanol içinde konsantre varlnda ileme tabi tutulur. sülfürik asit, kantitatif bir verimle metil esteri 38 verdi. Esasen ayn ekilde, 3- (nonil) dodekanoik asit veya 3- (tridesil) ISOCETYL PALMITATE (zosetil Palmitat) (40), hemen hemen kantitatif verimlerde karlk gelen metil esterleri 41 verdi. Metil esterlerin kuru eter içinde LiAlH4 ile indirgenmesi, srasyla, ilgili alkoller 39 ve 42’yi iyi verimlerle verdi (ema 8). 11 n = 5 ve m = 7 olan homolog seri, cis-9,10-metilen-ISOCETYL PALMITATE (zosetil Palmitat) içerir, ve n = 5 ve m = 9 olan homolog seri, laktobasilik asidi (cis-11,12-metilen-oktadekanoik asit) içerir. N = 7 ve m = 6 olan homolog seri, dihidromalvalik asidi (sistematik ad: 2-oktil-siklopropaneheptanoik asit) içerir ve n = 7 ve m = 7 olan homolog seri, dihidrosterkulik asidi (sistematik ad: cis-9,10 -metilen-oktadekanoik asit), bkz. ekil 6. n-heptanoik asit (nC = 7) ve n-hekISOCETYL PALMITATE (zosetil Palmitat) (nC = 16) aralndaki deneysel Hf verileri (Tablo A3), türetmek için eitim seti olarak kullanlmtr. Denklem eklinde bir QPPR.N-alkanoik asit serisi için 3. Veri için belirsizlik seviyesi <% 0,2 ile <% 3 arasnda deiir. Elde edilen sonuç parametre deerleri: B0 = (3.461 ± 0.076) × 107 ve B1 = 1.005525 ± 0.026, korelasyon katsays R2 = 0.998967 ve rasgele datlm bir kalnt grafii (ekil A3). N-merkaptanlarda olduu gibi, B1’in deeri esasen 1’dir. Esansiyel yalar, (2E) -heksenal (% 26.61), ISOCETYL PALMITATE (zosetil Palmitat) (% 10.14) gibi ana bileiklerle çemen otu yapraklarnn temel bileenleridir. ve dierleri arasnda (E) -β-ionon (% 7.99) (Riasat ve dierleri, 2017). Ancak bu ho kokulu moleküller tohumlarn ana bileeni deildir ve burada farmakolojik olarak ilgili bileenler olarak ele alnmamtr. Shahinuzzaman ve arkadalar tarafndan yaplan belirli bir analiz çalmasnda. (2015), çemen otu tohumlarnn uçucu ya bileenlerinin ana bileenler olarak ya asitleri içerdii gösterilmitir: dekan, 5,6-bis (2,2-dimetilpropiliden) -, (E, Z) – (% 19.58), ISOCETYL PALMITATE (zosetil Palmitat) metil ester (% 18.81) ve dihidro metil jasmonat (% 10.99) (Tablo 17.1). Bu nedenle, ya asitleri ve türevleri, çemen tohumlarnn temel uçucu ya bileenleridir. Centaurea türlerinin uçucu yalarnn içerii, seskiterpen iskeletinin (karyofilen, ödesmol ve germacren) varl ile karakterize edilir; hidrakarbonlar (tricosane, pentacosane ve heptacosane); ya asitleri (ISOCETYL PALMITATE (zosetil Palmitat), tetradekanoik asit ve dodekanoik asit) ve monoterpenler (aspinen, terpinen ve karvakrol) [72-74]. Ya asitlerinin ortak isimleri IUPAC isimlerinden daha sk kullanlmaktadr (Tablo 31.1). En yaygn doymu ya asitleri, ISOCETYL PALMITATE (zosetil Palmitat) ve stearik asitler srasyla 16 ve 18 karbon atomu içerir. IUPAC isimleri srasyla ISOCETYL PALMITATE (zosetil Palmitat) ve oktadekanoik asittir. Aromatikler ve bunlarn türevleri, örnein benzen, metilbenzen ve fenol, ISOCETYL PALMITATE (zosetil Palmitat) gibi ya asitleri, aminler ve amidler gibi nitrojen içeren bileikler ve dier grup alkoller, aldehitler ve ketonlar oksijen içeren bileiklerdi. Etanol-su yardmc çözücüsü (EWCS) içindeki DL daha datcyd ve nispi içerii,% 15.06’lk bal içerii olan ISOCETYL PALMITATE (zosetil Palmitat) etil ester haricinde% 10’dan daha düüktü. Tipik olarak, HTL’de üretilen hekzadekanoik asit içerii% 17.27’ye ulat, ancak EWCS’de% 9.79’a ve saf etanolde% 3.21’e düerken, hekzadekanoik asit etil ester içerii HTL’de% 0’dan EWCS’de% 15.06’ya yükseldi ve daha sonra Saf etanol içinde% 38.4. Ayrca, 5,8,11,14-eikosatetraenoik asit, etil ester, (all-Z) – ve etil linoleat gibi dier etil esterler de EWCS’den elde edilen biyo-ya ve saf etanolden daha yüksekti. Bu, svlatrma sistemine etanol eklenmesinin, ISOCETYL PALMITATE (zosetil Palmitat) gibi asidik bileenlerle reaksiyona girerek ve eterletirme olarak bilinen ISOCETYL PALMITATE (zosetil Palmitat) etil ester gibi karlk gelen esterleri elde ederek bir substrat görevi görebileceini gösterdi. Biswas vd. [41], Sargassum tenerrimum yosundan türetilmi biyo-yan GS-MS’sinden, 280 ° C’de HTL için bir çözücü olarak su (STW280) kullanlarak gözlemlendi; 3-piridiol, p-hidroksibifenil, ISOCETYL PALMITATE (zosetil Palmitat), bis (2-etilheksil ) ftalat, stigmastan-3,5-dien ve heksadekanamid.Çözücü olarak C2H5OH (ST-E280) için ana bileikler, hekzadekanoik asit-etil ester, etil oleat, tetradekanoik asit-etil ester ve izosorbitti. Hekzadekanoik asit-metil ester, metil tetradekanoat, 8-oktadekenoik asit metil ester ve metil heksadek-9-enoat elde edilen biyo-yada ana konsantrasyonlarda bulunan bileiklerdir. Siklik fosfat ve siklopropan içeren ISOCETYL PALMITATE (zosetil Palmitat) oluan bu bileik, 10 μg / mL’lik bir konsantrasyonda afinite ile saflatrlm dana timus DNA polimeraz α aktivitesinin% 80’inden fazlasn inhibe etti. Siklopropan içeren ISOCETYL PALMITATE (zosetil Palmitat) (81) bir diastereomerinin hazrlanmas, mezo’nun enzimatik hidrolizi ile balayarak ema 7’de özetlenmitir. diester (74) ISOCETYL PALMITATE (zosetil Palmitat) Palmitik asit (hekzadekanoik asit olarak da bilinir), hayvanlarda ve bitkilerde doal olarak bulunan ve ayrca laboratuar ortamlarnda oluturulabilen bir ya asididir. ISOCETYL PALMITATE (zosetil Palmitat), kiisel bakm ürünleri ve kozmetikler de dahil olmak üzere çeitli uygulamalarda yaygn olarak kullanlmaktadr.ISOCETYL PALMITATE (zosetil Palmitat), farazi zararl etkileri nedeniyle uzun süredir olumsuz olarak tasvir edilmitir ve çok önemli fizyolojik aktivitelerini gölgelemektedir. ISOCETYL PALMITATE (zosetil Palmitat), insan vücudundaki toplam ya asitlerinin% 20-30’unu oluturan en yaygn doymu ya asididir ve diyette salanabilir veya de novo lipogenesis (DNL) yoluyla endojen olarak sentezlenebilir. ISOCETYL PALMITATE (zosetil Palmitat) doku içerii iyi tanmlanm bir konsantrasyon etrafnda kontrol ediliyor gibi görünmektedir ve almndaki deiiklikler doku konsantrasyonunu önemli ölçüde etkilememektedir çünkü eksojen kaynak ISOCETYL PALMITATE (zosetil Palmitat) endojen biyosentezi ile dengelenmektedir. Belirli fizyopatolojik durumlar ve beslenme faktörleri DNL’yi güçlü bir ekilde indükleyerek ISOCETYL PALMITATE (zosetil Palmitat)’nn doku içeriinin artmasna ve doku konsantrasyonunun bozulmu homeostatik kontrolüne neden olabilir. ISOCETYL PALMITATE (zosetil Palmitat) doku konsantrasyonunun sk homeostatik kontrolü, membrann fiziksel özelliklerini garanti etmedeki temel fizyolojik rolüyle ve ayn zamanda protein palmitoilasyonunu, palmitoiletanolamid (PEA) biyosentezini ve akcierde etkili bir yüzey aktif madde aktivitesiyle ilgilidir. Membran fosfolipitlerinin (PL) dengesini korumak için, doymam ya asitleri, özellikle hem n-6 hem de n-3 ailelerinin PUFA’lar ile belirli bir oranda optimal ISOCETYL PALMITATE (zosetil Palmitat) alm çok önemli olabilir. Bununla birlikte, pozitif enerji dengesi, ar karbonhidrat alm (özellikle mono ve disakkaritler) ve hareketsiz bir yaam tarz gibi dier faktörlerin varlnda, sabit bir ISOCETYL PALMITATE (zosetil Palmitat) konsantrasyonu durumunu sürdürme mekanizmalar bozulabilir ve bu da ar doku birikimine neden olabilir. Dislipidemi, hiperglisemi, toll benzeri reseptör 4 yoluyla artan ektopik ya birikimi ve artm inflamatuar ton ile sonuçlanan ISOCETYL PALMITATE (zosetil Palmitat) bu nedenle, diyetle alnan ISOCETYL PALMITATE (zosetil Palmitat)’nn zararl salk etkileriyle ilikisi hakkndaki tartmal verilerin ar diyet dengesizlii ile ilikili olmas muhtemeldir. Baz fizyopatolojik koullarda ve gelimi DNL varlnda ISOCETYL PALMITATE (zosetil Palmitat) / PUFA oran, bu zararl etkileri daha da hzlandrabilir.ISOCETYL PALMITATE (zosetil Palmitat) (16: 0, ISOCETYL PALMITATE (zosetil Palmitat)), insan vücudunda bulunan en yaygn doymu ya asididir ve diyette salanabilir veya dier ya asitleri, karbonhidratlar ve amino asitlerden endojen olarak sentezlenebilir. Ortalama 70 kg erkek 3,5 Kg ISOCETYL PALMITATE (zosetil Palmitat)’dan oluur. Adndan da anlalaca gibi, ISOCETYL PALMITATE (zosetil Palmitat) hurma yann önemli bir bileenidir (toplam yalarn% 44’ü), ancak önemli miktarlarda ISOCETYL PALMITATE (zosetil Palmitat) da et ve süt ürünlerinde (toplam yalarn% 50-60′) ve kakao yanda bulunabilir. (% 26) ve zeytinya (% 8–20). Ayrca, ISOCETYL PALMITATE (zosetil Palmitat) anne sütünde toplam yalarn% 20-30’u ile bulunur. ISOCETYL PALMITATE (zosetil Palmitat) doku konsantrasyonunun sk homeostatik kontrolü, muhtemelen çeitli biyolojik ilevlerdeki temel fizyolojik rolü ile ilgilidir. Yakn zamanda Innis (Innis, 2016) tarafndan kapsaml bir ekilde revize edildii gibi özellikle bebeklerde ISOCETYL PALMITATE (zosetil Palmitat) çok önemli bir rol oynamaktadr. Ateroskleroz, nörodejeneratif hastalklar ve kanser gibi farkl fizyopatolojik durumlarda ortaya çkan ISOCETYL PALMITATE (zosetil Palmitat) homeostatik dengesinin bozulmas, genellikle diyet katksna baklmakszn kontrolsüz ISOCETYL PALMITATE (zosetil Palmitat) endojen biyosenteziyle ilgilidir.FA sentezi sitratn asetil-CoA’ya ve ardndan malonile dönüümü ile balar. -CoA, daha sonra palmitat ve dier FA’y oluturmak için uzatlr. Bu süreçteki anahtar enzimler, DNL snrlayc adm reaksiyonunu katalize eden asetil-CoA karboksilaz (ACC) ve FA sentazdr (FAS). DNL için ana sitrat kaynaklar, özellikle hipoksi veya mitokondriyal oksidatif mekanizmann bozulmas durumunda glikoz ve glutamin türevi α-ketoglutarattr (α-KG). ISOCETYL PALMITATE (zosetil Palmitat) veya ISOCETYL PALMITATE (zosetil Palmitat), bulunan en yaygn doymu ya asitlerinden biridir. ISOCETYL PALMITATE (zosetil Palmitat), sabun, kozmetik ve endüstriyel kalp ayrclarn üretiminde kullanlr. ISOCETYL PALMITATE (zosetil Palmitat) ayrca su sertliinin belirlenmesinde kullanlr ve intravenöz ultrasonik kontrast madde olan Levovist’in yüzey aktif maddesidir. veya IUPAC terminolojisindeki ISOCETYL PALMITATE (zosetil Palmitat), hayvanlarda, bitkilerde ve mikroorganizmalarda bulunan en yaygn doymu ya asididir. [9] [10] Kimyasal formülü CH3 (CH2) 14COOH ve C: D 16: 0’dr. Adndan da anlalaca gibi, palmiye ya (palmiye ya) meyvesinden elde edilen yan önemli bir bileenidir. ISOCETYL PALMITATE (zosetil Palmitat) ayrca etlerde, peynirlerde, tereyanda ve dier süt ürünlerinde bulunabilir. Palmitatlar, ISOCETYL PALMITATE (zosetil Palmitat) tuzlar ve esterleridir. Palmitat anyonu, fizyolojik pH’ta (7.4) gözlenen ISOCETYL PALMITATE (zosetil Palmitat) formudur. ISOCETYL PALMITATE (zosetil Palmitat) ve naftenik asidin alüminyum tuzlar, napalm üretmek için II.Dünya Sava srasnda birletirildi. “Napalm” kelimesi naftenik asit ve ISOCETYL PALMITATE (zosetil Palmitat) kelimelerinden türetilmitir. ISOCETYL PALMITATE (zosetil Palmitat), 1840 ylnda Edmond Frémy tarafndan sabunlatrlm hurma yanda kefedilmitir. [11] Hurma yandaki trigliseridlerin (yalar) yüksek scaklktaki suyla (200 ° C veya 390 ° F’nin üzerinde) hidrolize edilmesi ve elde edilen karmn saf ürünü vermek üzere fraksiyonel olarak damtlmasyla bu, üretimi için birincil endüstriyel yol olmaya devam ediyor. [12 ] ISOCETYL PALMITATE (zosetil Palmitat), tipik olarak düük seviyelerde, çok çeitli baka bitkiler ve organizmalar tarafndan doal olarak üretilir. Tereya, peynir, süt ve etin yan sra kakao ya, soya fasulyesi ya ve ayçiçek yanda doal olarak bulunur. Karukas% 44.90 ISOCETYL PALMITATE (zosetil Palmitat) içerir. [13]ISOCETYL PALMITATE (zosetil Palmitat) (setil palmitat) setil esteri, ispermeçette oluur.ISOCETYL PALMITATE (zosetil Palmitat) Özellikler ISOCETYL PALMITATE (zosetil Palmitat) veya IUPAC adlandrmasndaki heksadekanoik asit, hayvanlarda, bitkilerde ve mikroorganizmalarda bulunan en yaygn doymu ya asididir. [9] [10] Kimyasal formülü CH3 (CH2) 14COOH ve C: D 16: 0’dr. Adndan da anlalaca gibi, palmiye ya (palmiye ya) meyvesinden elde edilen yan önemli bir bileenidir. ISOCETYL PALMITATE (zosetil Palmitat) ayrca etlerde, peynirlerde, tereyanda ve dier süt ürünlerinde bulunabilir. Palmitatlar, ISOCETYL PALMITATE (zosetil Palmitat) tuzlar ve esterleridir. Palmitat anyonu, fizyolojik pH’ta (7.4) gözlenen ISOCETYL PALMITATE (zosetil Palmitat) formudur. ISOCETYL PALMITATE (zosetil Palmitat) ve naftenik asidin alüminyum tuzlar, napalm üretmek için II.Dünya Sava srasnda birletirildi. “Napalm” kelimesi naftenik asit ve ISOCETYL PALMITATE (zosetil Palmitat) kelimelerinden türetilmitir. ISOCETYL PALMITATE (zosetil Palmitat), 1840 ylnda Edmond Frémy tarafndan sabunlatrlm hurma yanda kefedilmitir. [11] Hurma yandaki trigliseridlerin (yalar) yüksek scaklktaki suyla (200 ° C veya 390 ° F’nin üzerinde) hidrolize edilmesi ve elde edilen karmn saf ürünü vermek üzere fraksiyonel olarak damtlmasyla bu, üretimi için birincil endüstriyel yol olmaya devam ediyor. [12 ] ISOCETYL PALMITATE (zosetil Palmitat), tipik olarak düük seviyelerde, çok çeitli baka bitkiler ve organizmalar tarafndan doal olarak üretilir. Tereya, peynir, süt ve etin yan sra kakao ya, soya fasulyesi ya ve ayçiçek yanda doal olarak bulunur. Karukas% 44.90 ISOCETYL PALMITATE (zosetil Palmitat) içerir. [13] ISOCETYL PALMITATE (zosetil Palmitat) setil esteri (setil palmitat), spermasette oluur ve vücuttaki fazla karbonhidrat ISOCETYL PALMITATE (zosetil Palmitat) dönütürülür. ISOCETYL PALMITATE (zosetil Palmitat), ya asidi sentezi srasnda üretilen ilk ya asididir ve daha uzun ya asitlerinin öncüsüdür. Sonuç olarak, ISOCETYL PALMITATE (zosetil Palmitat), hayvanlarn ana vücut bileenidir. nsanlarda, bir analiz, insan deposu yann% 21-30’unu (molar) oluturduunu buldu [14] ve anne sütünün önemli, ancak oldukça deiken bir lipid bileenidir. [15] Palmitat, asetil-CoA’y malonil-CoA’ya dönütürmekten sorumlu olan asetil-CoA karboksilaz (ACC) negatif olarak geri besler, bu da büyüyen asil zincirine eklenmek için kullanlr ve böylece daha fazla palmitat oluumunu önler.[16] Biyolojide, baz proteinler, palmitoilasyon olarak bilinen bir süreçte bir palmitoil grubunun eklenmesiyle modifiye edilir. Palmitoilasyon, birçok proteinin membran lokalizasyonu için önemlidir.ISOCETYL PALMITATE (zosetil Palmitat), sabunlar, kozmetikler ve endüstriyel kalp ayrc ajanlar üretmek için kullanlr. Bu uygulamalarda, genellikle hurma yann sabunlatrlmasyla elde edilen sodyum palmitat kullanlr. Bu amaçla, palmiye aacndan (Elaeis guineensis türü) elde edilen hurma ya, ester gruplarnn hidrolizine neden olarak gliserol ve sodyum palmitat veren sodyum hidroksit (kostik soda veya kül suyu formunda) ile ilenir. ucuzdur ve ilenmi gdalara (hazr gda) doku ve “az hissi” katar, ISOCETYL PALMITATE (zosetil Palmitat) ve sodyum tuzu, gda maddelerinde geni kullanm alan bulur. Organik ürünlerde doal katk maddesi olarak sodyum palmitata izin verilmektedir. [17] Alüminyum tuzu, askeri eylemlerde kullanlan napalm kalnlatrc bir madde olarak kullanlr.ISOCETYL PALMITATE (zosetil Palmitat) hidrojenasyonu, deterjan ve kozmetik üretiminde kullanlan setil alkolü verir. Son zamanlarda, uzun etkili bir antipsikotik ilaç olan paliperidon palmitat (INVEGA Sustenna olarak pazarlanmaktadr) izofreni tedavisinde kullanlan, kas içine enjekte edildiinde uzun etkili salm tayc ortam olarak yal palmitat ester kullanlarak sentezlenmitir. Altta yatan ilaç verme yöntemi, özellikle haloperidol dekanoat gibi nöroleptikler gibi uzun etkili depo ilaçlarnn verilmesi için dekanoik asitle kullanlana benzerdir.Dünya Salk Örgütü’ne göre, kantlar, ISOCETYL PALMITATE (zosetil Palmitat) tüketiminin arttn “ikna edicidir”. kardiyovasküler hastalk gelitirme riski [18], kandaki LDL düzeylerini artrabileceini gösteren çalmalara dayanmaktadr. Retinil palmitat, süt yann çkarlmasyla kaybedilen vitamin içeriinin yerini almas için az yal süte eklenen bir A vitamini kaynadr. Palmitat, sütte A vitamini stabil hale getirmek için A vitamini, retinol alkol formuna balanr.Ticari olarak temin edilebilen 2- (desil) dodesanoik asit veya 2- (tetradesil) hekzadekanoik asit (37), metanol içinde konsantre varlnda ileme tabi tutulur. sülfürik asit, kantitatif bir verimle metil esteri 38 verdi. Esasen ayn ekilde, 3- (nonil) dodekanoik asit veya 3- (tridesil) ISOCETYL PALMITATE (zosetil Palmitat) (40), hemen hemen kantitatif verimlerde karlk gelen metil esterleri 41 verdi. Metil esterlerin kuru eter içinde LiAlH4 ile indirgenmesi, srasyla, ilgili alkoller 39 ve 42’yi iyi verimlerle verdi (ema 8). 11 n = 5 ve m = 7 olan homolog seri, cis-9,10-metilen-ISOCETYL PALMITATE (zosetil Palmitat) içerir, ve n = 5 ve m = 9 olan homolog seri, laktobasilik asidi (cis-11,12-metilen-oktadekanoik asit) içerir. N = 7 ve m = 6 olan homolog seri, dihidromalvalik asidi (sistematik ad: 2-oktil-siklopropaneheptanoik asit) içerir ve n = 7 ve m = 7 olan homolog seri, dihidrosterkulik asidi (sistematik ad: cis-9,10 -metilen-oktadekanoik asit), bkz. ekil 6. n-heptanoik asit (nC = 7) ve n-hekISOCETYL PALMITATE (zosetil Palmitat) (nC = 16) aralndaki deneysel Hf verileri (Tablo A3), türetmek için eitim seti olarak kullanlmtr. Denklem eklinde bir QPPR.N-alkanoik asit serisi için 3. Veri için belirsizlik seviyesi <% 0,2 ile <% 3 arasnda deiir. Elde edilen sonuç parametre deerleri: B0 = (3.461 ± 0.076) × 107 ve B1 = 1.005525 ± 0.026, korelasyon katsays R2 = 0.998967 ve rasgele datlm bir kalnt grafii (ekil A3). N-merkaptanlarda olduu gibi, B1’in deeri esasen 1’dir. Esansiyel yalar, (2E) -heksenal (% 26.61), ISOCETYL PALMITATE (zosetil Palmitat) (% 10.14) gibi ana bileiklerle çemen otu yapraklarnn temel bileenleridir. ve dierleri arasnda (E) -β-ionon (% 7.99) (Riasat ve dierleri, 2017). Ancak bu ho kokulu moleküller tohumlarn ana bileeni deildir ve burada farmakolojik olarak ilgili bileenler olarak ele alnmamtr. Shahinuzzaman ve arkadalar tarafndan yaplan belirli bir analiz çalmasnda. (2015), çemen otu tohumlarnn uçucu ya bileenlerinin ana bileenler olarak ya asitleri içerdii gösterilmitir: dekan, 5,6-bis (2,2-dimetilpropiliden) -, (E, Z) – (% 19.58), ISOCETYL PALMITATE (zosetil Palmitat) metil ester (% 18.81) ve dihidro metil jasmonat (% 10.99) (Tablo 17.1). Bu nedenle, ya asitleri ve türevleri, çemen tohumlarnn temel uçucu ya bileenleridir. Centaurea türlerinin uçucu yalarnn içerii, seskiterpen iskeletinin (karyofilen, ödesmol ve germacren) varl ile karakterize edilir; hidrakarbonlar (tricosane, pentacosane ve heptacosane); ya asitleri (ISOCETYL PALMITATE (zosetil Palmitat), tetradekanoik asit ve dodekanoik asit) ve monoterpenler (aspinen, terpinen ve karvakrol) [72-74]. Ya asitlerinin ortak isimleri IUPAC isimlerinden daha sk kullanlmaktadr (Tablo 31.1). En yaygn doymu ya asitleri, ISOCETYL PALMITATE (zosetil Palmitat) ve stearik asitler srasyla 16 ve 18 karbon atomu içerir. IUPAC isimleri srasyla ISOCETYL PALMITATE (zosetil Palmitat) ve oktadekanoik asittir. Aromatikler ve bunlarn türevleri, örnein benzen, metilbenzen ve fenol, ISOCETYL PALMITATE (zosetil Palmitat) gibi ya asitleri, aminler ve amidler gibi nitrojen içeren bileikler ve dier grup alkoller, aldehitler ve ketonlar oksijen içeren bileiklerdi. Etanol-su yardmc çözücüsü (EWCS) içindeki DL daha datcyd ve nispi içerii,% 15.06’lk bal içerii olan ISOCETYL PALMITATE (zosetil Palmitat) etil ester haricinde% 10’dan daha düüktü. Tipik olarak, HTL’de üretilen hekzadekanoik asit içerii% 17.27’ye ulat, ancak EWCS’de% 9.79’a ve saf etanolde% 3.21’e düerken, hekzadekanoik asit etil ester içerii HTL’de% 0’dan EWCS’de% 15.06’ya yükseldi ve daha sonra Saf etanol içinde% 38.4. Ayrca, 5,8,11,14-eikosatetraenoik asit, etil ester, (all-Z) – ve etil linoleat gibi dier etil esterler de EWCS’den elde edilen biyo-ya ve saf etanolden daha yüksekti. Bu, svlatrma sistemine etanol eklenmesinin, ISOCETYL PALMITATE (zosetil Palmitat) gibi asidik bileenlerle reaksiyona girerek ve eterletirme olarak bilinen ISOCETYL PALMITATE (zosetil Palmitat) etil ester gibi karlk gelen esterleri elde ederek bir substrat görevi görebileceini gösterdi. Biswas vd. [41], Sargassum tenerrimum yosundan türetilmi biyo-yan GS-MS’sinden, 280 ° C’de HTL için bir çözücü olarak su (STW280) kullanlarak gözlemlendi; 3-piridiol, p-hidroksibifenil, ISOCETYL PALMITATE (zosetil Palmitat), bis (2-etilheksil ) ftalat, stigmastan-3,5-dien ve heksadekanamid.Çözücü olarak C2H5OH (ST-E280) için ana bileikler, hekzadekanoik asit-etil ester, etil oleat, tetradekanoik asit-etil ester ve izosorbitti. Hekzadekanoik asit-metil ester, metil tetradekanoat, 8-oktadekenoik asit metil ester ve metil heksadek-9-enoat elde edilen biyo-yada ana konsantrasyonlarda bulunan bileiklerdir. Siklik fosfat ve siklopropan içeren ISOCETYL PALMITATE (zosetil Palmitat) oluan bu bileik, 10 μg / mL’lik bir konsantrasyonda afinite ile saflatrlm dana timus DNA polimeraz α aktivitesinin% 80’inden fazlasn inhibe etti. Siklopropan içeren ISOCETYL PALMITATE (zosetil Palmitat) (81) bir diastereomerinin hazrlanmas, mezo’nun enzimatik hidrolizi ile balayarak ema 7’de özetlenmitir. diester (74) ISOCETYL PALMITATE (zosetil Palmitat) Palmitik asit (hekzadekanoik asit olarak da bilinir), hayvanlarda ve bitkilerde doal olarak bulunan ve ayrca laboratuar ortamlarnda oluturulabilen bir ya asididir. ISOCETYL PALMITATE (zosetil Palmitat), kiisel bakm ürünleri ve kozmetikler de dahil olmak üzere çeitli uygulamalarda yaygn olarak kullanlmaktadr.ISOCETYL PALMITATE (zosetil Palmitat), farazi zararl etkileri nedeniyle uzun süredir olumsuz olarak tasvir edilmitir ve çok önemli fizyolojik aktivitelerini gölgelemektedir. ISOCETYL PALMITATE (zosetil Palmitat), insan vücudundaki toplam ya asitlerinin% 20-30’unu oluturan en yaygn doymu ya asididir ve diyette salanabilir veya de novo lipogenesis (DNL) yoluyla endojen olarak sentezlenebilir. ISOCETYL PALMITATE (zosetil Palmitat) doku içerii iyi tanmlanm bir konsantrasyon etrafnda kontrol ediliyor gibi görünmektedir ve almndaki deiiklikler doku konsantrasyonunu önemli ölçüde etkilememektedir çünkü eksojen kaynak ISOCETYL PALMITATE (zosetil Palmitat) endojen biyosentezi ile dengelenmektedir. Belirli fizyopatolojik durumlar ve beslenme faktörleri DNL’yi güçlü bir ekilde indükleyerek ISOCETYL PALMITATE (zosetil Palmitat)’nn doku içeriinin artmasna ve doku konsantrasyonunun bozulmu homeostatik kontrolüne neden olabilir. ISOCETYL PALMITATE (zosetil Palmitat) doku konsantrasyonunun sk homeostatik kontrolü, membrann fiziksel özelliklerini garanti etmedeki temel fizyolojik rolüyle ve ayn zamanda protein palmitoilasyonunu, palmitoiletanolamid (PEA) biyosentezini ve akcierde etkili bir yüzey aktif madde aktivitesiyle ilgilidir. Membran fosfolipitlerinin (PL) dengesini korumak için, doymam ya asitleri, özellikle hem n-6 hem de n-3 ailelerinin PUFA’lar ile belirli bir oranda optimal ISOCETYL PALMITATE (zosetil Palmitat) alm çok önemli olabilir. Bununla birlikte, pozitif enerji dengesi, ar karbonhidrat alm (özellikle mono ve disakkaritler) ve hareketsiz bir yaam tarz gibi dier faktörlerin varlnda, sabit bir ISOCETYL PALMITATE (zosetil Palmitat) konsantrasyonu durumunu sürdürme mekanizmalar bozulabilir ve bu da ar doku birikimine neden olabilir. Dislipidemi, hiperglisemi, toll benzeri reseptör 4 yoluyla artan ektopik ya birikimi ve artm inflamatuar ton ile sonuçlanan ISOCETYL PALMITATE (zosetil Palmitat) bu nedenle, diyetle alnan ISOCETYL PALMITATE (zosetil Palmitat)’nn zararl salk etkileriyle ilikisi hakkndaki tartmal verilerin ar diyet dengesizlii ile ilikili olmas muhtemeldir. Baz fizyopatolojik koullarda ve gelimi DNL varlnda ISOCETYL PALMITATE (zosetil Palmitat) / PUFA oran, bu zararl etkileri daha da hzlandrabilir.ISOCETYL PALMITATE (zosetil Palmitat) (16: 0, ISOCETYL PALMITATE (zosetil Palmitat)), insan vücudunda bulunan en yaygn doymu ya asididir ve diyette salanabilir veya dier ya asitleri, karbonhidratlar ve amino asitlerden endojen olarak sentezlenebilir. Ortalama 70 kg erkek 3,5 Kg ISOCETYL PALMITATE (zosetil Palmitat)’dan oluur. Adndan da anlalaca gibi, ISOCETYL PALMITATE (zosetil Palmitat) hurma yann önemli bir bileenidir (toplam yalarn% 44’ü), ancak önemli miktarlarda ISOCETYL PALMITATE (zosetil Palmitat) da et ve süt ürünlerinde (toplam yalarn% 50-60′) ve kakao yanda bulunabilir. (% 26) ve zeytinya (% 8–20). Ayrca, ISOCETYL PALMITATE (zosetil Palmitat) anne sütünde toplam yalarn% 20-30’u ile bulunur. ISOCETYL PALMITATE (zosetil Palmitat) doku konsantrasyonunun sk homeostatik kontrolü, muhtemelen çeitli biyolojik ilevlerdeki temel fizyolojik rolü ile ilgilidir. Yakn zamanda Innis (Innis, 2016) tarafndan kapsaml bir ekilde revize edildii gibi özellikle bebeklerde ISOCETYL PALMITATE (zosetil Palmitat) çok önemli bir rol oynamaktadr. Ateroskleroz, nörodejeneratif hastalklar ve kanser gibi farkl fizyopatolojik durumlarda ortaya çkan ISOCETYL PALMITATE (zosetil Palmitat) homeostatik dengesinin bozulmas, genellikle diyet katksna baklmakszn kontrolsüz ISOCETYL PALMITATE (zosetil Palmitat) endojen biyosenteziyle ilgilidir.FA sentezi sitratn asetil-CoA’ya ve ardndan malonile dönüümü ile balar. -CoA, daha sonra palmitat ve dier FA’y oluturmak için uzatlr. Bu süreçteki anahtar enzimler, DNL snrlayc adm reaksiyonunu katalize eden asetil-CoA karboksilaz (ACC) ve FA sentazdr (FAS). DNL için ana sitrat kaynaklar, özellikle hipoksi veya mitokondriyal oksidatif mekanizmann bozulmas durumunda glikoz ve glutamin türevi α-ketoglutarattr (α-KG). ISOCETYL PALMITATE (zosetil Palmitat) veya ISOCETYL PALMITATE (zosetil Palmitat), bulunan en yaygn doymu ya asitlerinden biridir. ISOCETYL PALMITATE (zosetil Palmitat), sabun, kozmetik ve endüstriyel kalp ayrclarn üretiminde kullanlr. ISOCETYL PALMITATE (zosetil Palmitat) ayrca su sertliinin belirlenmesinde kullanlr ve intravenöz ultrasonik kontrast madde olan Levovist’in yüzey aktif maddesidir. veya IUPAC terminolojisindeki ISOCETYL PALMITATE (zosetil Palmitat), hayvanlarda, bitkilerde ve mikroorganizmalarda bulunan en yaygn doymu ya asididir. [9] [10] Kimyasal formülü CH3 (CH2) 14COOH ve C: D 16: 0’dr. Adndan da anlalaca gibi, palmiye ya (palmiye ya) meyvesinden elde edilen yan önemli bir bileenidir. ISOCETYL PALMITATE (zosetil Palmitat) ayrca etlerde, peynirlerde, tereyanda ve dier süt ürünlerinde bulunabilir. Palmitatlar, ISOCETYL PALMITATE (zosetil Palmitat) tuzlar ve esterleridir. Palmitat anyonu, fizyolojik pH’ta (7.4) gözlenen ISOCETYL PALMITATE (zosetil Palmitat) formudur. ISOCETYL PALMITATE (zosetil Palmitat) ve naftenik asidin alüminyum tuzlar, napalm üretmek için II.Dünya Sava srasnda birletirildi. “Napalm” kelimesi naftenik asit ve ISOCETYL PALMITATE (zosetil Palmitat) kelimelerinden türetilmitir. ISOCETYL PALMITATE (zosetil Palmitat), 1840 ylnda Edmond Frémy tarafndan sabunlatrlm hurma yanda kefedilmitir. [11] Hurma yandaki trigliseridlerin (yalar) yüksek scaklktaki suyla (200 ° C veya 390 ° F’nin üzerinde) hidrolize edilmesi ve elde edilen karmn saf ürünü vermek üzere fraksiyonel olarak damtlmasyla bu, üretimi için birincil endüstriyel yol olmaya devam ediyor. [12 ] ISOCETYL PALMITATE (zosetil Palmitat), tipik olarak düük seviyelerde, çok çeitli baka bitkiler ve organizmalar tarafndan doal olarak üretilir. Tereya, peynir, süt ve etin yan sra kakao ya, soya fasulyesi ya ve ayçiçek yanda doal olarak bulunur. Karukas% 44.90 ISOCETYL PALMITATE (zosetil Palmitat) içerir. [13]ISOCETYL PALMITATE (zosetil Palmitat) (setil palmitat) setil esteri, ispermeçette oluur.