ISOPROPYL MYRISTATE (IZOPROPL MRSTAT)
sopropyl Myristate (ZOPROPL MRSTAT)
CAS Number: 110-27-0
EC Number:203-751-4
Synonyms:
isopropyl myristate;isopropylmyristate;ISOPROPYL MYRISTATE;Isopropyl tetradecanoate;110-27-0;Estergel;Promyr;Tetradecanoic acid, 1 methylethylester;Bisomel;Isomyst;Kesscomir;Tegester;Deltyl Extra;Sinnoester MIP;Crodamol IPM;Plymoutm IPM;Starfol IPM;Unimate IPM;Kessco IPM;Emcol-IM;Wickenol 101;Stepan D-50;Emerest 2314;JA-FA IPM;Kessco isopropyl myristate;Crodamol I.P.M.;Deltylextra;Myristic acid isopropyl ester;Tetradecanoic acid, isopropyl;Tetradecanoic acid, isopropyl ester;isopropylmyristate;Myristic acid, isopropyl ester;1-Methylethyl tetradecanoate;Caswell No. 511E;UNII- 0RE8K4LNJS;1-Tridecanecarboxylic acid, isopropyl ester;NSC 406280;FEMA No. 3556;HSDB 626;IPM-EX;IPM-R;EINECS 203-751-4;propan-2-yl tetradecanoate;EPA Pesticide Chemical Code 000207;Isopropyl tetradecanoic acid;BRN 1781127;CHEBI:90027;IPM 100;AXISYYRBXTVTFY-UHFFFAOYSA-N;MFCD00008982;NCGC00164071-01;WE(2:0 (1Me)/14:0);DSSTox_CID_6838;Isopropyl myristate, 98%;DSSTox_RID_78224;DSSTox_GSID_26838;Q-201418;CAS-110-27-0;Isopropyl myristate [USAN];Tegosoft M;Isopropyl myristate [USAN:NF];Liponate IPM;Lexol IPM;Crodamol I.P.M;Estergel (TN);myristic acid isopropyl;PubChem19813;ACMC-1BVUK;methylethyl tetradecanoate;Radia 7190;E(R)EAEaOi+/-uo yen;Isopropyl myristate (NF);0RE8K4LNJS;iso-Propyl N-tetradecanoate;AC1L1Q4R;SCHEMBL2442;component of Sardo Bath Oil;Myristic acid- isopropyl ester;KSC174S6R;Isopropyl myristate, >=98%;CHEMBL207602;IPM 90;Jsp000796;DTXSID0026838;WLN: 13VOY1&1;CTK0H4968;MolPort-003-927-101;Tetradecanoic acid methyethyl ester;E(R)EAI(1/4)EaOi+/-uo yen;ZINC8214588;Isopropyl myristate, >=90% (GC);Tox21_112080,Tox21_202065;Tox21_303171;ANW- 16142;LMFA07010677;NSC406280;AKOS015902296;Myristic acid, isopropyl ester (8CI);Tox21_112080_1;LS-2869;NSC-406280;RL00430;RTR-002139;Isopropyl tetradecanoate, 98% 100ml;component of Sardo Bath Oil (Salt/Mix);NCGC00164071-02;NCGC00164071-03;NCGC00256937-01;NCGC00259614-01;AN-22595;CC-29682;KB- 77952;LP003008;R524;SC-19093;DB-040910;TR-002139,FT-0629053;M0481;D02296;C-28193;SR-01000944751;Isopropyl myristate, Vetec(TM) reagent grade, 98%;SR- 01000944751-1;I14-13725;Isopropyl myristate, United States Pharmacopeia (USP) Reference Standard;TETRADECANOIC ACID,ISOPROPYL ESTER (MYRISTATE,ISOPROPYLESTER);Isopropyl myristate, pharmaceutical secondary standard; traceable to USP and PhEur;1405-98-7;852553-53-8;InChI=1/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H;1-METHYLETHYL ESTER TETRADECANOIC ACID; 1-METHYLETHYL TETRADECANOATE; IPM; ISOPROPYL ESTER MYRISTIC ACID; ISOPROPYLTETRADECONOATE; MYRISTIC ACID, ISOPROPYL ESTER; TETRADECANOIC ACID, 1-METHYLETHYL ESTER; TETRADECANOIC ACID, 1METHYLETHYL ESTER; 1-TRIDECANECARBOXYLIC ACID,ISOPROPYL ESTER; BISOMEL; CRODACOL IPM; propan-2-yl tetradecanoate; C17H34O2; isopropyl myristate; isopropylmyristate; ISOPROPYL MYRISTATE; Isopropyltetradecanoate; 110-27-0; Estergel; Promyr; Tetradecanoic acid, 1-methylethyl ester; Bisomel; Isomyst; Kesscomir; Tegester; Deltyl Extra; Sinnoester MIP;Crodamol IPM; Plymoutm IPM; Starfol IPM; Unimate IPM; Kessco IPM; Emcol-IM; Wickenol 101; Stepan D-50; Emerest 2314; JA-FA IPM; Kessco isopropyl myristate;Crodamol I.P.M.; Deltylextra; Myristic acid isopropyl ester; Tetradecanoic acid, isopropyl; Tetradecanoic acid, isopropyl ester; isopropylmyristate; Myristicacid, isopropyl ester; 1-Methylethyl tetradecanoate; Caswell No. 511E; UNII-0RE8K4LNJS, 1-Tridecanecarboxylic acid, isopropyl ester; NSC 406280; FEMA No.3556; EINECS 203-751-4; EPA Pesticide Chemical Code 000207; Isopropyl tetradecanoic acid; BRN 1781127; CHEBI:90027; IPM 100; AXISYYRBXTVTFY-; Isopropyl myristate, 98%; CAS-110-27-0; Isopropyl myristate [USAN]; Tegosoft M; Isopropyl myristate [USAN:NF]; Liponate IPM; Lexol IPM; Crodamol I.P.M; Estergel (TN);myristic acid isopropyl; PubChem19813; methylethyl tetradecanoate; Radia 7190; E(R)EAEaOi+/-uo yen; Isopropyl myristate (NF); 0RE8K4LNJS; propan-2-yltetradecanoate; iso-Propyl N-tetradecanoate; AC1L1Q4R; SCHEMBL2442; component of Sardo Bath Oil; KSC174S6R; Isopropyl myristate, >=98%; CHEMBL207602;Tetradecanoic acid methyethyl ester; E(R)EAI(1/4)EaOi+/-uo yen; ZINC8214588; Isopropyl myristate, >=90% (GC); Myristic acid, isopropyl ester (8CI); ZOPROPLMRSTAT; izo propil miristat; isopropil miristat; izopropil miristat; ispropyl miristat; isopropyl miristat; izopropil myristate;bisomel;crodamol IPM;deltylextra;dermol IPM;edenor IEM 17;emcol-IM;emerest 2314;estergel;exceparl IPM;hallstar IPM;hallstar IPM-NF;IPM;kessco IPM;kesscomir;liponate IPM;1-methyl ethyltetradecanoate;1-methylethyl tetradecanoate;myristic acid isopropyl ester;myristic acid, isopropyl ester;iso myst;nikkol IPM-100;nikkol IPM-EX;promyr;propan-2-yl tetradecanoate;iso propyl myristate USP/NF;iso propyl tetradecanoate;iso propylmyristate;sinnoester MIP;starfolIPM;tegester;tetradecanoic acid 1-methyl ethyl ester;tetradecanoic acid 1-methylethyl ester;tetradecanoic acid isopropyl ester;tetradecanoic acid, 1-methylethyl ester;tetradecanoic acid, isopropyl ester;1-tridecane carboxylic acid isopropyl ester;1-tridecanecarboxylic acid, isopropyl ester;unimateIPM;wickenol 101;110-27-0 [RN];13VOY1&1 [WLN];1-Methylethyl tetradecanoate;203-751-4 [EINECS];Isopropyl myristate [ACD/IUPAC Name] [USAN];isopropyltetradecanoate;Isopropylmyristat [German] [ACD/IUPAC Name];Myristate d’isopropyle [French] [ACD/IUPAC Name];myristic acid isopropyl ester;Myristic acid,Tetradecanoic acid 1-methylethyl ester;Tetradecanoic acid isopropyl ester;Tetradecanoic acid, 1-methylethyl ester[ACD/Index Name];Tetradecanoic acid, isopropyl ester;1-Tridecanecarboxylic acid, isopropyl ester;4-02-00-01132 (Beilstein Handbook Reference)[Beilstein];Bisomel;Crodamol 1PM;Crodamol IPM;DELTYL EXTRA;Deltylextra;EINECS 203-751-4;Emcol-IM;Emerest 2314;Estergel [Trade name];Estergel (TN);FEMA3556;IPM;IPM 100;IPM 90;IPM-EX;IPM-R;Isomyst;Isopropyl myristate (NF);iso-Propyl N-tetradecanoate;Isopropyl tetradecanoic acid;Isopropylmyristate;Ja-faIPM;Jsp000796;Kessco IPM;Kessco isopropyl myristate;Kesscomir;Lexol IPM;Liponate IPM;Methylethyl tetradecanoate;MFCD00008982 [MDL number];Myristic acid-isopropyl ester;NCGC00164071-01;Promyr;Radia 7190;Sinnoester MIP;Starfol IPM;Stepan D-50;Tegester;Tegosoft M;Tetradecanoic acid methyethylester;Tetradecanoic acid, isopropyl;UNII:0RE8K4LNJS;UNII-0RE8K4LNJS;Unimate IPM;Wickenol 101;WLN: 13VOY1&1;XB8600000;ISOPROPYL TETRADECANOATE, TETRADECANOICACID ISOPROPYL ESTE;ISO-PROPYL N-TETRADECANOATE;ISOPROPYL TETRADECANOATE;BISOMEL;ISOPROPYL MYRISTATE;ESTERGEL;FEMA 3556;MYRISTIC ACID ISOPROPYLESTER;TETRADECANOIC ACID 1-METHYLETHYL ESTER;Cholesteryl myristate 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE Glycerol tristearate Nystatin Cholesterylpalmitate 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE ISOPROPYL CINNAMATE Myristic acid Dimethyl succinate Methyl acrylate Isopropanol Allylisothiocyanate Isopropyl myristate ISOPROPYL LAURATE Titanium tetraisopropanolate Isopropyl salicylate Diisopropyl azodicarboxylate Isopropylpalmitate;Myristic Acid Isopropyl Ester; 1-Methylethyl tetradecanoate; Bisomel; Crodacol IPM; Crodamol IPM; D 50; D 50 (emollient); Deltyl Extra; Emcol IM;Emerest 2314; Estol 1512; Estol 1514; Estol IPM 1512; Exceparl IPM; IPM; IPM 100; IPM-EX; IPM-R; Isomyst; Isopropyl myristate; Isopropyl myristate-PM;Isopropyl tetradecanoate; Kessco IPM; Kesscomir; Kollicream IPM; Lexol IPM; Liponate IPM; Matlube IPM-S; NSC 406280; Nikkol IPM; Nikkol IPM 100; Nikkol IPM-EX; Pastell IP 14; Pelemol IPM; Promyr; Radia 7190; Rilanit IPM; Sinnoester MIP; Stepan D 50; Stepan IPM; Tegosoft M; Wickenol 101;4-Acetoxy-ß-damascone 3-Acetoxy-2,2-dimethylbutyryl Chloride 2-Acetoxy-2-methyl-1-propanol Acrylic Acid (stabilized with MEHQ) 1-Adamantanecarboxylic Acid Methyl Ester;IPM 90;propan-2-yl tetradecanoate; myristic acid isopropyl ester; Tetradecanoic acid, 1-methylethyl ester; Tetradecanoic acid, isopropyl ester;ISO PROPILENMYRISTATE;ISOPROPILENMYRISTATE;iso propilen myristate;isopropilenmyristate;IZOPROPL MRSTAT;ZOPROPLMRSTAT;izo propil miristat;izopropilmiristat; sopropyl Myristate; Isopropyl tetradecanoate; 110-27-0; Tetradecanoic acid, 1-methylethyl ester; Estergel; Bisomel; Isomyst; Promyr; Deltyl Extra; Kesscomir; Tegester; Sinnoester MIP; Crodamol IPM; Plymoutm IPM; Starfol IPM; Unimate IPM; Kessco IPM; Emcol-IM; Wickenol 101; Stepan D-50; Emerest 2314; 1-Methylethyl tetradecanoate; sopropyl Myristate; isopropyl ester; Kessco sopropyl Myristate; Crodamol I.P.M.; Deltylextra; Tetradecanoic acid, isopropyl; sopropyl Myristate, isopropyl ester; Tetradecanoic acid, isopropyl ester; 1; Tridecanecarboxylic acid, isopropyl ester; sopropyl Myristate [USAN]; methylethyl tetradecanoate; EINECS 203-751-4; EPA Pesticide; Chemical Code 000207; iso-Propyl N-tetradecanoate; BRN 1781127; CHEBI:90027; Tetradecanoic acid; methyethyl ester; sopropyl Myristate, 96%; sopropyl Myristate, 98%; Isopropyl tetradecanoic acid; isopropylmyristate; propan-2-yl tetradecanoate; CAS-110-27-0; sopropyl Myristate (NF); Myristic acid-isopropyl ester; sopropyl Myristate, >=98%; sopropyl Myristate ; ZOPROPL MRSTAT; Isopropyl Myristate ; IZOPROPL MRSTAT; izopropyl Myristate ; SOPROPL MRSTAT; izopropil miristat; izopropilmiristat; isopropil miristat; isopropyl myristat; isopropylmyristat; isopropyl myristad; isopropyl myristade; izopropyl myristad; izopropyl myristad; izopropyl myristade; sopropil miristat; sopropyl myristat; sopropylmyristat; sopropyl myristad; sopropyl myristade; zopropyl myristad; zopropyl myristad; zopropyl myristade; zopropil miristat; izopropil miristat
SOPROPYL MYRSTATE
sopropyl Myristate
sopropyl myristate
Names
IUPAC name
Propan-2-yl tetradecanoate
Other names
Tetradecanoic acid, 1-methylethyl ester
Myristic acid isopropyl ester
Identifiers
CAS Number
110-27-0 ☑
3D model (JSmol)
Interactive image
ChemSpider
7751 ☒
ECHA InfoCard 100.003.412
EC Number
203-751-4
KEGG
D02296 ☒
MeSH C008205
PubChem CID
8042
RTECS number
XB8600000
CompTox Dashboard (EPA)
DTXSID0026838 Edit this at Wikidata
InChI[show]
SMILES[show]
Properties
Chemical formula
C17H34O2
Molar mass 270.457 g·mol-1
Density 0.85 g/cm³
Boiling point 167 °C (333 °F; 440 K) at 9 mmHg
Hazards
R-phrases (outdated) R38
S-phrases (outdated) S24/25
NFPA 704 (fire diamond)
NFPA 704 four-colored diamond
100
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒ verify (what is ☑☒ ?)
Infobox references
sopropyl Myristate (IPM) is the ester of isopropyl alcohol and myristic acid.
Uses
sopropyl Myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired. sopropyl Myristate is being studied as a skin enhancer. It is also used as a pesticide against head lice which works by dissolving the wax that covers the exoskeleton of head lice, killing them by dehydration.[2] It is used in the same way in flea and tick killing products for pets.
sopropyl Myristate is used to remove bacteria from the oral cavity as the non-aqueous component of the two-phase mouthwash product “Dentyl pH”.
sopropyl Myristate is also used as a solvent in perfume materials, and in the removal process of prosthetic make-up.
Hydrolysis of the ester from sopropyl Myristate can liberate the acid and the alcohol. The acid could be responsible for decreasing of the pH value of formulations.[3][4]
Product Name: sopropyl Myristate
Structure
CAS110-27-0
SynonymsBISOMEL; Myristic acid isopropyl ester; ESTERGEL; Isopropyl Tetradecanoate; Isopropyl-myristate; 1-methylethyl ester of tetradecanoic acid; i-propyl myristate; ja-faipm; Emcol-IM; myristic acid isopropyl ester; IPM 100,IPM-EX,IPM-R; Isomyst; IPM; D 50; isopropyl myristinate; Promyr; Revenge; Tegester;
EC Number203-751-4
IUPAC Namepropan-2-yltetradecanoate
Molecular FormulaC17H34O2
Molecular Weight270
Exact Mass270.25600
Boiling Point167ºC (9 mmHg)
Melting Point-5°C
Flash Point308°F
Density0.856 (25°C)
AppearanceColorless or slightly yellow oily liquid
SMILESCCCCCCCCCCCCCC(=O)OC(C)C
InChI KeyAXISYYRBXTVTFY-UHFFFAOYSA-N
Safty DescriptionS26-S36
Hazard StatementsXi:Irritant
WGK Germany-
StabilityStable. Combustible. Incompatible with strong oxidizing agents.
Packing GroupI; II; III
Viscosity4.8cp (25°C)
Alpha Sortsopropyl Myristate
sopropyl myristate is a moisturizer with polar characteristics used in cosmetics and topical medical preparations to ameliorate the skin absorption. sopropyl Myristate has been largely studied and impulsed as a skin penetration enhancer. At the moment the primary usage for which sopropyl Myristate is formally indicated is as the active ingredient in a non-prescription pediculicide rinse.
DrugBank
Isopropyl tetradecanoate is a fatty acid ester.
ChEBI
Therapeutic Uses HelpNew Window
… sopropyl Myristate 50% in cyclomethicone solution (Full Marks Solution – SSL International) is a new fluid treatment with a physical mode of action that uses a 10-minute contact time /for treatment of head lice.
PMID:19423676
Drug Ther Bull 47 (5): 50-2 (2009) (No authors given)
HSDB
/Experimental Therapy/ … A pediculicide rinse, 50% sopropyl Myristate (IPM), was assessed in two phase 2 trials conducted in North America. The first trial was a nonrandomized (proof of concept) trial without a comparator conducted in Winnipeg, Canada. The second trial, conducted in the United States, was an evaluator-blinded, randomized superiority trial comparing 50% IPM rinse with a positive control (RID; pyrethrin 0.33%, piperonyl butoxide 4%). The primary end points were to determine the safety and efficacy of 50% IPM as a pediculicide rinse. METHODS: Subjects meeting inclusion criteria were enrolled in the above-mentioned trials with efficacy end points 7 and 14 days post-treatment. Subjects were also evaluated on days 0, 7, 14, and 21 for the presence of erythema and edema using the Modified Draize Scale. Other comments associated with the safety evaluation (ie, pruritus) were collected. RESULTS: IPM was found to be effective in the proof of concept study and comparator trial using a positive control. IPM was also well tolerated, with minimal adverse events. All adverse events were mild, resolving by completion of the study. CONCLUSION: Data suggest that IPM is a safe and effective therapy for the treatment of head lice in children and adults. IPM’s mechanical mechanism of action makes development of lice resistance unlikely.
PMID:17942025
Kaul N et al; J Cutan Med Surg 11 (5): 161-7 (2007)
HSDB
… Due to their distinct advantages such as enhanced drug solubility, thermodynamic stability, facile preparation, and low cost, uses and applications of microemulsions have been numerous. Recently, there is a surge in the exploration of microemulsion for transdermal drug delivery for their ability to incorporate both hydrophilic (5-fluorouracil, apomorphine hydrochloride, diphenhydramine hydrochloride, tetracaine hydrochloride, and methotrexate) and lipophilic drugs (estradiol, finasteride, ketoprofen, meloxicam, felodipine, and triptolide) and enhance their permeation…. Besides surfactants, oils can also act as penetration enhancers (oleic acid, linoleic acid, sopropyl Myristate, isopropyl palmitate, etc.). …
PMID:19016057
Azeem A et al; Drug Dev Ind Pharm 35 (5): 525-47(2009)
HSDB
/Experimental Therapy/ Alpha-tocopherol (AT) is the vitamin E homologue with the highest in vivo biological activity. AT protects against the carcinogenic and mutagenic activity of ionizing radiation and chemical agents, and possibly against UV-induced cutaneous damage. For stability consideration, alpha-tocopherol is usually used as its prodrug ester, alpha-tocopherol acetate (ATA), which once absorbed into the skin is hydrolyzed to alpha-tocopherol, the active form. … Permeation studies were conducted using modified Franz diffusion cells and human cadaver skin as the membrane. Specifically, 5% (w/w) alpha-tocopherol acetate was formulated in the following vehicles: ethanol, sopropyl Myristate, light mineral oil, 1% Klucel gel in ethanol, and 3% Klucel gel in ethanol (w/w). … The permeabilities of ATA through human cadaver skin were 1.0×10-4, 1.1×10-2, 1.4×10-4, 2.1×10-4, and 4.7×10-4 cm/hr for the ethanol solution, sopropyl Myristate solution, light mineral oil solution, 1% Klucel gel, and 3% Klucel gel, respectively. The results show that the formulation had relatively minor effects on the permeability coefficients of ATA through cadaver skin in all cases except for the sopropyl Myristate solution.
PMID:15868062
Mahamongkol H et al; J Cosmet Sci 56 (2): 91-103 (2005)
HSDB
/Experimental Therapy/ The purpose of this research was to prepare a pseudolatex transdermal delivery system for terbutaline sulfate and to evaluate the effect of pH and organic ester penetration enhancers on permeation kinetics of terbutaline sulfate through mice abdominal skin and human cadaver skin. … The permeation profile and related kinetic parameters of terbutaline sulfate was determined in presence of 3 ester-type permeation enhancers incorporated in the films, viz methyl laureate, isopropyl lanolate, and sopropyl Myristate. Among the 3, the more pronounced enhancing effect was obtained with sopropyl Myristate, regarding the permeation flux, permeability coefficient, and diffusion coefficient. This was attributed to solubility parameter of sopropyl Myristate being closer to the solubility parameter of human skin, and such a pronounced enhancing effect was probably caused by its passage across the skin barrier through the lipid pathway.
PMID:16353974
Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750528
Panigrahi L et al; AAPA PharmSciTech 6(2): E167-73 (2005)
HSDB
/Experimental Therapy/ A transdermal dosage form of trazodone hydrochloride (TZN) may be useful in the treatment of moderate to severe depression in schizophrenic patients by providing prolonged duration of action. … The aim of /this/ investigation was to evaluate its flux and the effects of various penetration enhancers, viz., sopropyl Myristate (IPM), isopropyl palmitate (IPP), butanol and octanol on transdermal permeation from matrix-based formulations through the skin. The enhancing effect on the permeation of TZN was determined using the mouse and human cadaver epidermis. … The highest enhancing effect was obtained with IPM followed by butanol, octanol and IPP. In general, higher fluxes were observed through mouse epidermis as compared with the human cadaver epidermis…
PMID:17438871
Das MK et al; Acta Pol Pharm 63 (6): 535-41 (2006)
HSDB
/Experimental Therapy/ The purpose of this study was to mechanistically investigate effects of isopropanol (IPA)-sopropyl Myristate (IPM) binary enhancers on transport of a model drug, estradiol (E2) in human epidermis (stratum corneum + viable epidermis) in vitro. The study was focused on use of the same IPA-IPM compositions on both sides of the skin (“symmetric” configuration) with saturated E2 (maximum thermodynamic activity). For E2 transport in all IPA-sopropyl Myristate compositions tested, stratum corneum still was the rate-limiting layer of human epidermis. The relative contributions to E2 flux enhancement were separated into the changes in solubility and diffusivity of E2 in stratum corneum. As a major factor, E2 solubility in stratum corneum was enhanced by 35 times with increasing IPA from neat sopropyl Myristate to neat IPA. E2 diffusivity in stratum corneum also played a significant role, which increased by 8 times from neat IPM to 50% IPA. Stratum corneum swelled more in IPM-rich region, decreased with increasing IPA, and even deswelled in neat IPA. IPA uptake correlated well to E2 solubility in stratum corneum; both linearly increased with increasing IPA. sopropyl Myristateuptake appeared to correlate to E2 diffusivity in stratum corneum; both maximized around 50% IPA.
Description: Ester of isopropyl alcohol and myristic acid (vegetable-derived). Low viscosity fluid non-greasy emollient, tolerates wide pH range, compatible with most surfactants. Thanks to its low viscosity and density, it has a high spreadability. Colorless oil-like liquid. No or little odor. Water-insoluble, but soluble with silicones, and hydrocarbons. Specific gravity 0.85 (at 20°C).
CAS: 110-27-0
INCI Name: sopropyl Myristate
Benefits:
Superior emollient for non-greasy bath, body and baby oils
Lubricant and compression aid for pressed powders
Light & non-tacky emollient for creams and lotions. Readily adsorbed by the skin
When used at high concentrations it gently lifts makeup and surface dirt
Gives gloss and shine to hair
Resistant to oxidation (does not become rancid)
Widely used as diluent for fragrance oils.
Use: Can be added to formulas as is, add to oil phase. Typical use level 1-20%. Required HLB: 11.5. Storage: Stable when kept in a closed container at a cool & dry place. For external use only.
Applications: Creams, lotions, hand creams, shampoo, shower gels, makeup removers, powders and foundations.
Country of Origin: USA
Raw material source: Vegetable oils (myristic acid) and isopropanol
Manufacture: sopropyl Myristate is produced by distillation, which is preceded by the esterification of myristic acid and isopropanol, alkali refined to neutralize the catalyst.
Animal Testing: Not animal tested
GMO: GMO free (does not contain plant-derived components)
Vegan: Does not contain animal-derived components
Documents: SDS, Fact Sheet, Sample Recipe, Certificate of Analysis
sopropyl Myristate
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Overview(active tab)
Safety
Resources
What Is sopropyl Myristate?
sopropyl Myristate is a fatty acid that occurs naturally in some foods. Purified sopropyl Myristate occurs as a hard, white or faintly yellow, glossy crystalline solid, or as a white or yellow-white powder. Salts of sopropyl Myristate (Aluminum Dimyristate, Aluminum Isostearates/Myristate, Aluminum Myristate, Aluminum Myristates/Palmitates, Calcium Myristate, Magnesium Myristate, Potassium Myristate, Sodium Myristate, Zinc Myristate) and esters of sopropyl Myristate (Butyl Myristate, Cetyl Myristate, Decyl Myristate, Ethylhexyl Myristate, Ethyl Myristate, Glyceryl Dimyristate, Glyceryl Isostearate/Myristate, Glyceryl Myristate, Isobutyl Myristate, Isocetyl Myristate, Isodecyl Myristate, sopropyl Myristate, Isostearyl Myristate, Isotridecyl Myristate, Lauryl Myristate, Methyl Myristate, Myristyl Myristate, Octyldodecyl Myristate, Oleyl Myristate, Propylene Glycol Myristate, Tetradecyloctadecyl Myristate, Tridecyl Myristate) may also be used in cosmetics and personal care products. sopropyl Myristate and its salts and esters may be used in eye makeup, soaps and detergents, hair care products, nail care products, shaving products and other skin care products.
Why is it used in cosmetics and personal care products?
The following functions have been reported for sopropyl Myristate and its salts and esters.
Anticaking agent – Aluminum Dimyristate, Aluminum Isostearates/Myristates, Aluminum Myristate, Aluminum Myristates/Palmitates, Calcium Myristate, Magnesium Myristate, Zinc Myristate
Binder – sopropyl Myristate, Isostearyl Myristate, Tetradecyloctyldecyl Myristate
Emulsion stabilizer – Aluminum Dimyristate, Aluminum Isostearates/Myristates, Aluminum Myristate, Aluminum Myristates/Palmitates, Calcium Myristate, Tetradecyloctyldecyl Myristate
Film former – Tetradecyloctyldecyl Myristate
Hair conditioning agent – Ethyl Myristate, Isotridecyl Myristate, Lauryl Myristate, Oleyl Myristate
Opacifying agent – sopropyl Myristate, Tetradecyloctyldecyl Myristate
Slip modifier – Magnesium Myristate, Zinc Myristate
Skin-Conditioning Agent – Emollient – Butyl Myristate, Ethylhexyl Myristate, Ethyl Myristate, Glyceryl Dimyristate, Glyceryl Isostearate/Myristate, Glyceryl Myristate, Isobutyl Myristate, Isodecyl Myristate, sopropyl Myristate, Isostearyl Myristate, Methyl Myristate, Propylene Glycol Myristate
Skin-conditioning agent – occlusive – Cetyl Myristate, Decyl Myristate, Isocetyl Myristate, Isotridecyl Myristate, Lauryl Myristate, Myristyl Myristate, Octyldodecyl Myristate, Oleyl Myristate, Tetradecyloctyldecyl Myristate, Tridecyl Myristate
Surfactant – cleansing agent – sopropyl Myristate, Potassium Myristate, Sodium Myristate
Surfactant – emulsifying agent – Potassium Myristate, Sodium Myristate, Glyceryl Isostearate/Myristate, Glyceryl Myristate, Propylene Glycol Myristate
Viscosity increasing agent – nonaqueous – Aluminum Dimyristate, Aluminum Isostearates/Myristates, Aluminum Myristate, Aluminum Myristates/Palmitates, Calcium Myristate, Magnesium Myristate, Zinc Myristate
Scientific Facts:
sopropyl Myristate, also called tetradecanoic acid, occurs naturally in vegetable or animal fats and oils with relatively high levels found in nutmeg, palm oil, coconut oil and butter fat. The salts of sopropyl Myristate are formed by reaction with base materials such as sodium or potassium hydroxide. The esters of sopropyl Myristate are derived from sopropyl Myristate and an alcohol. For example, sopropyl Myristate is derived from sopropyl Myristate and isopropyl alcohol, and Butyl Myristate is derived from sopropyl Myristate and butyl alcohol.
sopropyl Myristate
sopropyl Myristateis classified as :
Binding
Emollient
Skin conditioning
Solvent
Perfuming
CAS Number 110-27-0
EINECS/ELINCS No: 203-751-4
COSING REF No: 34699
INN Name: sopropyl Myristate
PHARMACEUTICAL EUROPEAN NAME: isopropylis myristas
Chem/IUPAC Name: Tetradecanoic acid, isopropyl ester
You’ve most likely heard of moisture-enabling ingredients glycerin and hyaluronic acid, but we’re willing to bet you’ve never heard of sopropyl Myristate. Though, if you were to do a quick scan of the skincare and personal care products currently in your bathroom, we’re also willing to bet that it’s in a large percentage of them. An emollient ingredient, sopropyl Myristate helps to strengthen the skin barrier, ensuring that moisture stays locked in. But, unlike other emollients, the benefits don’t stop there.
sopropyl Myristate is unique in that it’s able to enhance the penetration of other ingredients, not to mention it’s essential when it comes to formulating and creating products that are cosmetically elegant. Ahead, dermatologist Sapna Palep, MD, of Spring Street Dermatology in New York City, dermatologist Dan Belkin, MD, of Laser & Skin Surgery Center of New York, and Sheel Desai Solomon, MD, a dermatologist in Raleigh/Durham, North Carolina explain what sets this ingredient apart from its moisturizing counterparts.
sopropyl Myristate
TYPE OF INGREDIENT: Emollient, though it also acts as a thickening agent and lubricant in beauty products.
MAIN BENEFITS: Strengthens the skin’s natural moisture barrier to lock in hydration, enhances the penetration of other ingredients, thickens formulas, and makes those with a high oil content feel silky rather than greasy.
WHO SHOULD USE IT: sopropyl Myristate is ideal for anyone with normal to dry skin looking for moisturization benefits, according to Palep.
HOW OFTEN CAN YOU USE IT: For the best results, follow the directions on the product it’s found in, though daily or twice daily use is generally fine.
WORKS WELL WITH: sopropyl Myristate works well with an assortment of active ingredients, says Solomon, which is why it’s found in so many different types of products and formulas.
DON’T USE WITH: Because it does enhance penetration, it’s important to assess the other ingredients in the formula and whether this increased penetration can cause unexpected side effects such as irritation, cautions Palep.
What Is sopropyl Myristate?
A synthetic oil, sopropyl Myristate is made up of isopropyl alcohol-a propane derivative-and myristic acid, a naturally-occurring fatty acid, explains Palep. While it’s not necessarily a solo skincare star that you’ll find touted as a hero ingredient, it’s a popular cosmetic ingredient in a wide array of beauty products, found in everything from aftershave to anti-perspirants to anti-aging creams. Why so popular? First, there are the formulation benefits. “By thickening formulas, it gives products a denser texture and also improves the overall texture of those with a high oil content to be silky rather than greasy,” says Palep. And while that’s a major win for the labs and scientists making your beauty products, it does have skincare benefits for you, too. While there are plenty of emollients on the market, sopropyl Myristate has the added benefit of enhancing the penetration of other ingredients (more on that below).
Benefits of sopropyl Myristate For Skin
Strengthen’s the skin barrier: sopropyl Myristate keeps the outermost layer of the skin strong and intact. Think of the skin barrier as being made up of bricks and mortar: the cells are the bricks and all of the lipids (fats) are the mortar. sopropyl Myristate is that mortar, filling in cracks in between the skin cells so that moisture can’t escape.
sopropyl Myristate Softens the skin: As an emollient, sopropyl Myristate also helps soften and smooth dry skin, which is why this is a choice ingredient for those with dry or flaky skin.
Enhances the penetration of other ingredients: The exact mechanism by which this works isn’t fully clear, but it’s thought that sopropyl Myristate changes the structure of the stratum corneum, the most external layer of the skin, making it easier for active ingredients to absorb, explains Belkin. In turn, this can make the skincare you’re using more effective.
Side Effects of sopropyl Myristate
There’s one big caveat with this ingredient: “The one documented drawback to sopropyl Myristate is that it can clog pores,” notes Solomon. Translation: Those with acne or who are prone to breakouts should steer clear. And while it’s generally a good thing that it enhances penetration of other ingredients, this can also prove to be a double-edged sword. “Because it is a penetration enhancer, it may make irritation from other active ingredients more common,” cautions Belkin. He also points out that those with rosacea or particularly sensitive skin should be extra cautious about formulas that contain sopropyl Myristate along with powerful actives that can be irritating to begin with, such as retinoids and acids.
And, as with any other ingredients, there’s also a risk of allergic reaction.
How to Use sopropyl Myristate
Because sopropyl Myristate is found in so many different products and formulations, your best bet is to follow the instructions on any particular product.
Properties of isopropyl myristate
Molecular Formula:C17H34O2
Molecular Weight:270.457 g/mol
IUPAC Name:propan-2-yl tetradecanoate
Physical Description:Liquid
Color:Liquid of low viscosity of ISOPROPYL MYRISTATE
Boiling Point:588 K (315 deg C) at 760 mm Hg
Melting Point:Approximately 3 deg C
Density:0.8532 g/cu cm at 20 deg C
Isopropyl Myristate is a synthetic oil used as an emollient, thickening agent, or lubricant in beauty products. Composed of of Isopropyl Alcohol (a propanederivative) and Myristic Acid (a naturally-occurring fatty acid), Isopropyl Myristate is a popular cosmetic and pharmaceutical ingredient. It is most oftenused an an additive in aftershaves, shampoos, bath oils, antiperspirants, deodorants, oral hygiene products, and various creams and lotions.
Isopropyl myristate is the ester of isopropanol and myristic acid.Isopropyl Myristate is a synthetic oil used as an emollient, thickening agent, or lubricant in beauty products. Composed of of Isopropyl Alcohol (a propanederivative) and Myristic Acid (a naturally-occurring fatty acid), Isopropyl Myristate is a popular cosmetic and pharmaceutical ingredient. It is most oftenused an an additive in aftershaves, shampoos, bath oils, antiperspirants, deodorants, oral hygiene products, and various creams and lotions.
Uses of ISOPROPYL MYRISTATE
sopropyl myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired. Isopropyl myristate is being studied as a skin enhancer. It is also used as a pesticide against head lice which works by dissolving the wax that covers the exoskeleton of head lice, killing them by dehydration.
sopropyl myristate is used as a solvent in perfume materials.
sopropyl myristate is the non-aqueous component of the two-phase mouthwash, Dentyl pH, where it removes bacteria from the oral cavity.
sopropyl myristate is also used in the removal process of prosthetic make-up.
sopropyl myristate is also used in flea and tick products for pets.
The hydrolysis of the ester from isopropyl myristate can liberate the acid and the alcohol. The acid could be responsible for decreasing of the pH value of
formulations.
How is Isopropyl Myristate Used?
There are many reasons why skin care companies often include isopropyl myristate in their products. Perhaps one of the more common reasons is this chemical’s ability to moisturize the skin. As an emollient, isopropyl myristate helps strengthen the skin’s natural moisture barrier, which helps it stay hydrated by reducing moisture loss.
Another benefit of isopropyl myristate is its ability to thicken formulations, and give creams and deodorants a denser texture. Though this property may not directly improve the condition of the user’s skin, a thicker cream can feel more luxurious and thus improve the consumer’s enjoyment. Further, this allows some products, like deodorants, to be applied to the skin more smoothly.
Further, isopropyl myristate is valued for its ability to improve the overall texture of products with high oil content. Products with lots of oil can be amazingly beneficial for the skin, but the greasy feel can be a turn-off for many consumers. Additionally, greasiness caused by excess oil can make it impractical to use such creams in a professional setting. Including isopropyl myristate can be a useful addition to such products, as it will change the texture to be more silky, rather than greasy.
Lastly, isopropyl myristate is also believed to have strong skin penetrating properties. This is a valuable attribute, as isopropyl myristate can help other skin healing chemicals to penetrate more deeply; thus making personal care products more effective.
zopropil miristat
zopropil miristat [1]
Izopropil miristat
simler
IUPAC ad
Propan-2-il tetradekanoat
Dier isimler
Tetradekanoik asit, 1-metiletil ester
Miristik asit izopropil ester
Tanmlayclar
CAS numaras
110-27-0 ☑
3D model ( JSmol )
Etkileimli görüntü
ChemSpider
7751 ☒
ECHA Bilgi Kart 100.003.412
EC Numaras
203-751-4
KEGG
D02296 ☒
MeSH C008205
PubChem CID
8042
RTECS numaras
XB8600000
CompTox Kontrol Paneli ( EPA )
DTXSID0026838 Bunu Wikidata’da düzenle
InChI[göster]
SMILES[göster]
zopropil miristat Özellikleri
zopropil miristat Kimyasal formül
C- 17 , H 34 O 2
zopropil miristat Molar kütle 270.457 g · mol -1
zopropil miristat Younluk 0.85 g / cm³
zopropil miristat Kaynama noktas 9 mmHg’de 167 ° C (333 ° F; 440 K)
zopropil miristat Tehlikeler
R-ibareleri (eski) R38
S-ibareleri (eski) S24 / 25
NFPA 704 (ate prlanta)
NFPA 704 dört renkli elmas
100
Aksi belirtilmedikçe, standart halindeki malzemeler için veriler verilir (25 ° C [77 ° F], 100 kPa’da).
☒ dorula ( nedir ?) ☑☒
Bilgi kutusu referanslar
zopropil miristat (IPM) olan ester ve izopropil alkol ve miristik asit .
zopropil miristat Kullanmlar
zopropil miristat polar bir yumuatcdr ve cilde iyi emilim istenen kozmetik ve topikal tbbi preparatlarda kullanlr. zopropil miristat bir cilt arttrc olarak aratrlmaktadr. zopropil miristat Ba bitlerinin d iskeletini kaplayan balmumunu çözerek ve dehidrasyon ile öldürerek ba bitlerine kar bir pestisit olarak kullanlr . [2]zopropil miristat Evcil hayvanlar için pire ve kene öldürme ürünlerinde ayn ekilde kullanlr.
ki fazl gargara ürünü ” Dentil pH ” n sulu olmayan bileeni olarak az boluundan bakterileri uzaklatrmak için kullanlr .
zopropil miristat ayrca parfüm malzemelerinde ve protez makyajn çkarlma ileminde bir çözücü olarak kullanlr .
Esterin izopropil miristattan hidrolizi , asidi ve alkolü serbest brakabilir. Asit, formülasyonlarn pH deerinin düürülmesinden sorumlu olabilir. [3] [4]
ZOPROPL MRSTAT
HAMMADDE
BLGLER
zopropil miristat CAS
NUMARASI 110 – 27 – 0
KMYASAL
FORMÜLÜ CH3(CH2)12COOCH(CH3)2
MOLEKÜL
AIRLII 270, 45 GR / MOL
TCAR
SM ZOPROPL MRSTAT
ANALZ
BLGLER
SAFLIK
DERECES ( % ) 99
PARLAMA
NOKTASI ( C ) 152
KAYNAMA
NOKTASI ( C ) 208
ERME
NOKTASI ( C ) 3
PH
ARALII ÖLÇÜLMEMTR.
YOUNLUU 0,85 GR / CM3
ÇÖZÜNÜRLÜK SOUK SUDA ÇÖZÜNMEZ. SICAK KISMEN ÇÖZÜNÜR.
ZOPROPL MRSTAT
zopropil miristatn FZKSEL ÖZELLKLER VE KULLANILDII ALANLAR
zopropil miristat FZKSEL GÖRÜNÜMÜ SIVI
zopropil miristat RENK EFFAF VE HAFF SARIMTIRAK
zopropil miristat KOKU KARAKTERSTK BR KOKUSU VAR.
TEHLKE CLDE TEMASTA BR RRTASYONA NEDEN OLMAZ.
DEPOLAMA KOULLARI SERN VE NEM OLMAYAN YERDE VE KAPALI AMBALAJLARDA MUHAFAZA EDLMELDR.
KULLANILDII
ALANLAR
ZOPROPL MRSTAT, kozmetik sektöründe ve bilhassa el ve yüz kremlerinde, vücut kremlerinde ve anti – aging krem ve losyonlarda yalayc ajan olarak kullanlr.
ZOPROPL MRSTAT, tarm sektöründe ise, insektisit, fungusit ve herbisitlerle ilgili sv formda tarm ilaçlar üretilirken emülgatörlerle birlikte tayc olarak kullanlr.
ZOPROPL MRSTAT, hammaddesi dahil olmak üzere, bitki besleme,bitki koruma, insektisitler,fungusitler,akarisidler ve herbasitlere ait hammaddelerin fiziksel ve kimyasal özellikleri,kimyasal formülleri,çözünürlüü ve kullanld alanlara ait geni bilgileri TARIM HAMMADDELER ANSKLOPEDS içerisinde bulabilirsiniz.
ETKETLER: ZOPROPL MRSTAT nedir, zopropil miristat ZOPROPL MRSTAT nerede kullanlr, ZOPROPL MRSTAT kullanm, ZOPROPL MRSTAT msds, teknik özellikleri, ZOPROPL MRSTAT emülgatörü, emülgatör, ZOPROPL MRSTAT kimyasal formülü,molekül arl, ZOPROPL MRSTAT kaynama noktas,donma noktas,erime noktas,zopropil miristat ZOPROPL MRSTAT fiziksel özellikleri,kimyasal özellikleri,herbisit nedir,herbisitlerin zararlar,herbisid ile mücadele,herbisit ilaçlar,herbisid ilaçlar nelerdir, insektisit, insektisitler, insektisid etken maddeleri,fungusit nedir,fungusitler,fungusit ile mücadele,insektisitlerle mücadele yöntemleri,akarisitler,akarisit nedir,herbisit çeitleri,herbisit hammaddeleri,kimyasallar,herbisit hammadde, ZOPROPL MRSTAT zopropil miristat nasl çözünür, ZOPROPL MRSTAT içeren hammaddeler, ZOPROPL MRSTAT ne kadar kullanlr, nerelerde kullanlr, ZOPROPL MRSTAT zopropil miristat spesifikasyonu,fosforlu gübre yapm,azotlu gübreler, damlama gübreleri,sv yaprak gübreler, NPK gübre,np gübre,iz elementli gübre üretimi,gübre hesaplama,gübre hesaplamalar,gübre bileimi,kimyasal gübreler, organik gübre yapm,gübre nedir,sv organik gübreler,potasyumlu gübre,sv potasyum gübresi yapm,potasyumlu gübre içerii,içerik,insektisit ile mücadele yöntemi,herbisit çeitleri,sv kombi gübre yapm,kalsiyum gübresi,sv magnezyum gübre imalat,gübre formülleri,bitki besleme,bitki koruma gübreler,bitki geliim düzenleyici gübreler,herbisit nedir,herbitsitlerle mücadele,herbisit ile kültürel mücadele,herbisit ile ilaç mücadelesi,herbisit için etken maddeler,fungusit nedir,fungusitlerle mücadele,kültürel mücadele,ilaç ile mücadele,fungusidin zararlar,fungal bitki hastalklar,bitkilerde fungusitler,fungusit neden olur,fungusit çeitleri,fungusit etken maddeler,bitki büyüme düzenleyiciler,bitki besleme gübreler,gübre üretimleri,bitki koruma gübreler,bitki koruma ilaçlar,bitki geliim düzenleyicileri,edta elatl çinko yapm,edta elatl çinko nasl yaplr,edta elatl bakr, iz element gübre,edta elatl mangan,edta elatl demir,mikro elementli gübre formülü.
zopropil Miristat 1 Lt
zopropil Miristat Cosmetic Grade
Stok Kodu
Kategori
Laboratuvar Kimyasallar
Özel Durum
Kimyasal maddeler kategorisinde bulunan bir ksm tehlikeli kimyasallarn (zehirli, bayltc, patlayc yapda olabilecek ürünler) sat ahslara yaplmamaktadr.
zopropil miristat, izopropil alkol ve miristik asidin esteridir.
zopropil miristat,Formül: C17H34O2
zopropil miristat,Younluk: 850 kg/m³
zopropil miristat,Kaynama noktas: 167 °C
zopropil miristat,Molar kütle: 270,451 g/mol
zopropil miristat,PubChem Bileik Kimlik Numaras: 8042
Esterler
2-oktil dodesil miristat
Setil 2-etil hoekzanoat
Di-izostearil maleat
zopropil miristat
zopropil palmitat
Setil esterleri (Sentetik spermaceti)
zopropil miristat, iyi niyetle dolu yeil bir ya esteri!
zopropil miristat (CAS: 110-27-0; EC: 203-751-4), 1950’lerden beri kozmetik alannda yaygn olarak kullanlan bir ya asidi esteridir (miristik asidin izopropil esteri). Önemli yaylma gücü nedeniyle takdir edilmektedir. Ayn zamanda film oluturucu bir bileen olduu söylenir. Cosing bunu bir “balayc, yumuatc, maskeleme, parfüm maddesi” olarak sunar. Bunu yumuatc bir etki olarak kabul edersek, koku etkisi veya kötü kokular maskelemek, açklanmal, izopropil miristat mükemmel kokusuz bir svdr. “Koku, maskeleme” terimlerinin kullanmn hakl çkaran bir dizi koku molekülüne göre izopropil miristatn çözücü özellikleridir. Ancak gözlerimizde, izopropil miristat bundan çok daha fazlasdr … Bu bileen, bu nedenle, tüm özelliklerini dikkatlice detaylandrmak için bir Bak hak etti.
zopropil miristat “Yeil” bir içerik
Doada mevcut olmasa da, zopropil miristat la ilgili belirli sentez modlarn düünüyorsa, bu bileen “yeil” olarak nitelendirilebilir. zopropil miristat, aslnda, Candida antartica’dan lipaz B kullanlarak enzimatik sentez ile elde edilebilir.
Kantlanm penetrasyon arttrc etki
zopropil miristatn penetrasyon arttrc etkisi iyi belgelenmitir. Transdermal geçiin aratrlmas için 1970’lerde in vitro modellerde önerilen, bariyerin dier tarafn hzla geçiyor ve çeitli aktif tbbi bileenlerin penetrasyonunun kolaylatrcs olarak çallyor.3,4 bu bileen lipit zarlarn inceltebilir, böylece bileenlerin hücre içerisine nüfuz etmesini kolaylatrabilir.5 Sudan oluan bir hidroalkol karbomer jelde% 3 izopropil miristatn dahil edilmesi, Carbopol 980 ve soda, ciltteki testosteron akn alt kat çarpar.6 Bir lanolin merhemine dahil edilen izopropil alkol / izopropil miristat (1/1 orannda) karm, bu arada, içermeyen eksipiyan ile karlatrldnda betametazon-17-valerat akn 12 ile çarpmak. 7 Diklofenak sodyum içeren bir jel için de ayn ey geçerlidir. penetrasyon arttrclar (laktik asit, izopropil miristat, etanol), anti-enflamatuar preparatlarn formülasyonunun bir parças olarak gerçekletirilebilir.9 Baz transdermal yamalara dahil edilmesi durumunda, yapkann karakteristiklerinde bir azalma fenomeni sistem; bu durumda, izopropil miristatn söz konusu polimer için plastikletirici bir rol oynad söylenir. 10 Farmasötik alanda çok çallan bu penetrasyon arttrc etki, korkunun olduu kozmetik alanda göz ard edilir. cilde nüfuz etme kavramndan söz ederek tüketicileri korkutur. Sessiz ol, bu yüzden daha fazlasn söylemeyeceiz!
zopropil miristat üpheli bir antimikrobiyal etki
Bir oftalmik preparatn sterilitesini kontrol etmek istendiinde, mikroorganizmalar test edilecek dozaj formundan izole etmek için membran filtrasyonu gerçekletirilir. Test edilecek preparat seyreltmek için izopropil miristat bir çözücü olarak kullanldnda, baz bakteri sularnn duyarll nedeniyle yanl negatifleri gözlemleyebilecei fark edilir; özellikle Pseudomonas aeruginosa’y düüneceiz.11 Bu fenomen 1970’lerde belli sayda mikrobiyolog tarafndan gözlemlendi; Bazlar antimikrobiyal etkiyi esterletirmek için deil, hammaddede bulunan asit katalizörlerinin izlerine itti.1 Dikkat, son olarak, tüm mikroplar duyarl deildir (eer duyarllk varsa). zopropil miristatn B. subtilis ve E. coli üzerinde bir etkisi yoktur.12 Antimikrobiyal koruyucularn saysn ve dozunu en aza indirmek için çaba sarf edildii bir zamanda, dikkate alnmas yararl olabilir. Bu ya esterinin antimikrobiyal gücü hakknda adil bir fikir edinmek için bu çalmalar hatrlayn ve tekrar bu yönde kazn.
Aslnda, anti-bit losyonlarnn bileiminde% 50’ye girdiinde, nörotoksik pedikülisitler tip permetrin veya piretrin içermeyen bitleri etkili bir ekilde yok etmeyi mümkün kldn biliyoruz.13 Dernek zopropil silikon-miristat ayrca bit önleyici kontrol için iyi bir ikili.14
zopropil miristatn özellikleri
zopropil miristat Moleküler Formül: C17H34O2
zopropil miristat Molekül Arl: 270.457 g / mol
IUPAC Ad: propan-2-yl tetradecanoate
zopropil miristat Fiziksel Tanmlama: Sv
zopropil miristat Renk: ISOPROPYL MYRISTATE düük viskoziteli sv
zopropil miristat Kaynama Noktas: 760 mm Hg’de 588 K (315 derece)
zopropil miristat Erime Noktas: Yaklak 3 derece C
zopropil miristat Younluk: 20 ° C’de 0.8532 g / cu cm
zopropil miristat, güzellik ürünlerinde bir yumuatc, kvam arttrc madde veya yalayc olarak kullanlan sentetik bir yadr. zopropil Alkol (bir propan türevi) ve Miristik Asit (doal olarak oluan bir ya asidi) içeren zopropil miristat, popüler bir kozmetik ve farmasötik bileendir. Çou zaman, aftershaves, ampuan, banyo yalar, antiperspiranlar, deodorantlar, az hijyeni ürünleri ve çeitli kremler ve losyonlarda bir katk maddesi olarak kullanlr.
zopropil miristat, izopropanol ve miristik asit esteridir. zopropil Myristate, güzellik ürünlerinde bir yumuatc, kvam verici madde veya yalayc olarak kullanlan sentetik bir yadr. zopropil Alkol (bir propan türevi) ve Myristic Asit (doal olarak oluan bir ya asidi) içeren Isopropil Myristate, popüler bir kozmetik ve farmasötik bileendir.zopropil miristat Çou zaman, aftershaves, ampuan, banyo yalar, antiperspiranlar, deodorantlar, az hijyeni ürünleri ve çeitli kremler ve losyonlarda bir katk maddesi olarak kullanlr.
zopropil Miristat Kullanm Alanlar
zopropil miristat polar bir yumuatcdr ve cilde iyi bir ekilde emilimin arzu edildii kozmetik ve topikal ilaç preparasyonlarnda kullanlr. zopropil miristat cilt gelitirici olarak incelenmektedir. Ayn zamanda kafa bitlerinin d iskeletini örten balmumu eriterek ve onlar dehidrasyonla öldürerek çalan bit balarna kar bir böcek ilac olarak da kullanlr.
zopropil miristat Parfüm malzemelerinde solvent olarak kullanlr.
zopropil miristat Az boluundan bakterileri uzaklatran iki fazl gargara olan Dentyl pH’n sulu olmayan bir bileenidir.
zopropil miristat Protez kalba çkarma ileminde de kullanlr.
zopropil miristat Ayrca evcil hayvanlar için pire ve kene ürünlerinde de kullanlr.
zopropil miristat Esterin izopropil miristattan hidrolizi, asit ve alkolü serbest brakabilir. zopropil miristat , Asit, formülasyonlarn pH deerinin düürülmesinden sorumlu olabilir.
zopropil miristat nasl kullanlr?
Cilt bakm irketlerinin, ürünlerinde genellikle izopropil miristat içermesinin birçok nedeni vardr. Belki de en yaygn nedenlerden biri, bu kimyasaln cildi nemlendirmesidir. Bir yumuatc olarak, izopropil miristat, cildin doal nem bariyerini güçlendirmeye yardmc olur, bu da nem kaybn azaltarak nemlendirilmesine yardmc olur.
zopropil miristatn bir baka yarar, formülasyonlar kalnlatrmas ve kremler ve deodorantlara daha youn bir doku kazandrmasdr. Bu özellik, kullancnn cildinin durumunu dorudan iyiletirmese de, daha kaln bir krem daha lüks hissedebilir ve böylece tüketicinin zevkini artrabilir. Dahas, bu, deodorantlar gibi baz ürünlerin cilde daha pürüzsüz uygulanmasn salar.
Ayrca, izopropil miristat, yüksek ya içeriine sahip ürünlerin genel dokusunu gelitirme kabiliyetine deer verir. Çok fazla ya içeren ürünler olabilir cilt için inanlmaz derecede yararldr, ancak yal his birçok tüketici için bir kapanma olabilir. Ek olarak, fazla yan neden olduu yallk, bu tür kremleri profesyonel bir ortamda kullanmak için pratik olmaz. zopropil miristat dahil, bu tür ürünler için yararl bir katk olabilir, çünkü dokuyu yadan ziyade daha ipeksi bir ekilde deitirecektir.
Son olarak, izopropil miristatn ayrca güçlü cilt nüfuz özelliklerine sahip olduuna inanlmaktadr. Bu, isopropil miristatn dier cilt iyiletirici kimyasallarn daha derinlere nüfuz etmesine yardmc olabileceinden deerli bir özelliktir; Böylece kiisel bakm ürünlerini daha etkili hale getirir
Myristate d’isopropyle
Myristate d’isopropyle
Image illustrative de l’article Myristate d’isopropyle
Identification
Nom UICPA tétradécanoate de propan-2-yle
Myristate d’isopropyle No CAS 110-27-0
No ECHA 100.003.412
No CE 203-751-4
No RTECS XB8600000
PubChem 8042
SMILES
[Afficher]
InChI
[Afficher]
Apparence liquide incolore, inodore1 Propriétés chimiques du Myristate d’isopropyle
Formule brute C17H34O2 [Isomères]
Myristate d’isopropyle Masse molaire2 270,4507 ± 0,0166 g/mol
C 75,5 %, H 12,67 %, O 11,83 %,
Propriétés physiques du Myristate d’isopropyle
T° fusion de Myristate d’isopropyle 0 à 1 °C1
T° ébullition de Myristate d’isopropyle 140 °C (3 mbar)1
Solubilité de Myristate d’isopropyle 0,05 mg·l-1 (eau, 20 °C)1
Masse volumique de Myristate d’isopropyle 0,85 g·cm-3 (20 °C)1
T° d’auto-inflammation de Myristate d’isopropyle 300 °C1
Point d’éclair 150 °C1
Pression de vapeur saturante 1 mbar (20 °C)1
Viscosité dynamique 5,58 mPa·s (20 °C)1
Propriétés optiques
Indice de réfraction {displaystyle n_{D}^{20}}n^{ 20 }_{ D } 1,4343
Précautions
NFPA 7043
Symbole NFPA 704
100
Unités du SI et CNTP, sauf indication contraire.
modifier Consultez la documentation du modèle
Le myristate d’isopropyle (parfois abrégé MIP) est l’ester de l’acide myristique et de l’isopropanol. À température ambiante, c’est un liquide incolore et huileux.
Utilisations
Myristate d’isopropyle est un solvant organique. Myristate d’isopropyle est très utilisé en cosmétique et en pharmacie (en émulsion avec l’eau, pour faciliter la pénétration des produits dans la peau). Myristate d’isopropyle peut servir de traitement anti-poux sans pesticide : en dissolvant la cire qui couvre l’exosquelette des poux,Myristate d’isopropyle les tue par déshydratation4.Myristate d’isopropyle fait partie de certains bains de bouche comme anti-bactérien. Myristate d’isopropyle est employé pour retirer le maquillage par prothèses.
ISOPROPYL MYRISTATE
N° CAS : 110-27-0 – Myristate d’isopropyle
“Bien” dans toutes les catégories.
Nom INCI : ISOPROPYL MYRISTATE
Nom chimique : Tetradecanoic acid, isopropyl ester
N° EINECS/ELINCS : 203-751-4
Potentiel Comédogène (pc) : 5
Ses fonctions (INCI)
Agent fixant : Permet la cohésion de différents ingrédients cosmétiques
Emollient : Adoucit et assouplit la peau
Agent masquant : Réduit ou inhibe l’odeur ou le goût de base du produit
Agent parfumant : Utilisé pour le parfum et les matières premières aromatiques
Cet ingrédient est présent dans 3.26% des cosmétiques.
Shampooing sec (23,42%)
Masque pour cheveux (11,7%)
Huile capillaire (11,02%)
Déodorant spray (10,46%)
Stick à lèvres (10,04%)
LE MYRISTATE D’ISOPROPYLE, UN ESTER GRAS PLEIN DE BONNE VOLONTÉ QUI SE MET AU VERT !
> 07 AOÛT 2019
Le myristate d’isopropyle, un ester gras plein de bonne volonté qui se met au vert !
Le myristate d’isopropyle (CAS : 110-27-0 ; EC : 203-751-4) est un ester d’acide gras (ester isopropylique de l’acide myristique), très utilisé dans le domaine cosmétique, depuis les années 1950. Il est apprécié du fait de son pouvoir d’étalement important. On dit d’ailleurs de lui qu’il s’agit d’un ingrédient filmogène. Le Cosing le présente comme un « agent liant, émollient, masquant, parfumant ». Si nous lui reconnaissons bien un effet émollient, son effet parfumant ou masquant des mauvaises odeurs, en revanche, doit être expliqué, le myristate d’isopropyle étant un liquide parfaitement inodore. Ce sont les propriétés solvantes du myristate d’isopropyle à l’égard d’un certain nombre de molécules parfumantes qui justifient l’emploi des termes « parfumant, masquant ». Mais à nos yeux, le myristate d’isopropyle c’est beaucoup plus que cela… Cet ingrédient méritait donc un Regard afin de détailler soigneusement toutes ses propriétés.
Un ingrédient « vert »
Bien que n’existant pas dans la nature,1 cet ingrédient peut être qualifié de « vert », si l’on pense à certains modes de synthèse le concernant. Le myristate d’isopropyle peut, en effet, être obtenu par synthèse enzymatique, en ayant recours à la lipase B de Candida antartica.2
Un effet exhausteur de pénétration démontré
L’effet exhausteur de pénétration du myristate d’isopropyle est bien documenté. Proposé dans les années 1970 dans les modèles in vitro d’étude du passage transdermique, il passe rapidement de l’autre côté de la barrière et est étudié en tant que facilitateur de la pénétration de divers principes actifs médicamenteux.3,4 On sait que cet ingrédient est capable de fluidifier les membranes lipidiques, facilitant ainsi la pénétration des ingrédients au travers de la cellule.5 L’incorporation de 3 % de myristate d’isopropyle dans un gel hydroalcoolique de carbomère, composé d’eau, de Carbopol 980 et de soude, permet de multiplier le flux de testostérone au niveau cutané par un facteur six.6 Le mélange alcool isopropylique/myristate d’isopropyle (dans un rapport 1/1) incorporé dans une pommade à la lanoline est capable, quant à lui, de multiplier par 12 le flux de bétaméthasone-17-valérate par rapport à l’excipient n’en contenant pas.7 Même chose dans le cas d’un gel contenant du diclofénac sodique.8 Des associations d’exhausteurs de pénétration (acide lactique, myristate d’isopropyle, éthanol) peuvent être réalisées dans le cadre de la formulation de préparations anti-inflammatoires.9 En cas d’incorporation dans certains patchs transdermiques, on observe un phénomène de réduction du caractère adhésif du système ; on dit dans ce cas que le myristate d’isopropyle joue un rôle de plastifiant pour le polymère en question.10 Cet effet exhausteur de pénétration, très étudié dans le domaine pharmaceutique, est passé sous silence dans le domaine cosmétique où l’on craint de faire peur aux consommateurs en évoquant la notion de pénétration cutanée. Chut, on n’en dira donc pas plus !
Un effet antimicrobien présumé
Lorsque l’on veut contrôler la stérilité d’une préparation ophtalmique, on réalise une filtration sur membrane de façon à isoler les microorganismes de la forme galénique à tester. Lorsque l’on emploie comme solvant le myristate d’isopropyle afin de diluer la préparation à tester, on se rend compte que l’on peut observer des faux-négatifs du fait de la sensibilité de certaines souches bactériennes ; on pensera en particulier à Pseudomonas aeruginosa.11 Ce phénomène fut constaté dès les années 1970 par un certain nombre de microbiologistes ; certains imputèrent l’effet antimicrobien non pas à l’ester, mais à des traces de catalyseurs acides retrouvés dans la matière première.1 Attention, enfin, tous les germes ne sont pas aussi sensibles (si sensibilité il y a). Le myristate d’isopropyle est sans effet sur B. subtilis et E. coli.12 A une époque où l’on recherche à réduire au maximum le nombre et la dose d’emploi des conservateurs antimicrobiens, il est peut-être utile de se rappeler de ces travaux et de creuser à nouveau dans cette direction afin de se faire une idée juste du pouvoir antimicrobien de cet ester gras.
Un effet pédiculicide qui gagne à être connu
En 2008, on découvre une nouvelle qualité à cet ester. On se rend compte, en effet, qu’il permet d’éradiquer efficacement les poux, lorsqu’il entre pour 50 % dans la composition des lotions anti-poux, ne renfermant pas de pédiculicides neurotoxiques type perméthrine ou pyréthrine.13 L’association silicone-myristate d’isopropyle constitue également un bon duo pour la lutte anti-poux.14
Un ingrédient plutôt bien toléré
On ne note que très peu d’échos négatifs concernant cet ingrédient bien toléré. Pourtant, quelques cas d’allergies sont répertoriés. Entre 1992 et 2001, en Allemagne, sur 12 671 patients, l’incidence de sensibilisation à cet ingrédient calculée n’était que de 0,13 %.15 Le myristate d’isopropyle entrant dans la composition d’un grand nombre de cosmétiques en général et de crèmes émollientes en particulier, il faudra garder à l’esprit cet aspect de cette matière première. Lors d’un eczéma persistant, il sera important de se renseigner sur l’ensemble des cosmétiques employés par le patient.16 Noter également que le délai d’apparition des symptômes peut être long. Dans le cas d’un patient anglais sensibilisé à son produit de protection solaire, une éruption très prurigineuse au niveau du visage, du cou et des membres ne s’est manifestée que 3 jours après application du produit incriminé. Un patch test réalisé par le dermatologue grâce aux ingrédients contenus dans la formule fournis par le laboratoire commercialisant le produit solaire a montré des réactions positives à l’isohexadécane et au myristate d’isopropyle.17 Ces réactions sont rares mais méritent d’être signalées.
Un ingrédient comédogène
Parmi la liste des qualités attribuées au myristate d’isopropyle, il en est une qui ne peut lui être reconnue : sa compatibilité avec la peau du sujet acnéique. Cet ingrédient étant comédogène ;18 il devra donc être évité lors de la formulation de cosmétiques destinés à la « peau jeune » et ce de la même façon que des esters du même type : palmitate d’isopropyle, isostéarate d’isopropyle, stéarate de butyle, néopentanoate d’isostearyle, myristate de myristyle, oléate de décyle, stéarate d’octyle, palmitate d’octyle…19
Un ingrédient encore très étudié
Utilisé depuis de nombreuses années par l’industrie cosmétique, le myristate d’isopropyle fait toujours le bonheur de chercheurs du monde entier. C’est ainsi que l’on découvre dans la littérature scientifique une publication récente étudiant la stabilité de différents mélanges composés d’eau, de myristate d’isopropyle, d’octane, de dodécane, de butanol, de chlorure de sodium, de laurylsulfate de sodium, de bromure d’hexadécyltriméthylammonium. Des émulsions réalisées avec un protocole étrange (les alcools sont incorporés au goutte à goutte !),20 des formules peu exploitables… On comprend mal le but d’une telle recherche. A citer également le travail réalisé par deux chercheurs lillois qui ont formulé une émulsion de Pickering (émulsion composée d’eau, de myristate d’isopropyle, de nitrate d’éconazole stabilisée par des particules solides et non par un tensioactif classique) afin de proposer une nouvelle forme galénique pour le traitement des mycoses.21 Ce type d’émulsion, très étudiée en laboratoire, fait l’objet d’une véritable pluie de publications depuis sa première description en 1907 ;22 on notera, toutefois, qu’il n’existe pas, à ce jour, de formules sur le marché exploitant cette technologie.
Le myristate d’isopropyle, en bref
Cet ester ne manque pas de qualités, comme on a pu le constater. Excipient (du fait de son caractère filmogène, solvant) ou actif (du fait de son caractère émollient), le myristate d’isopropyle ne sait pas trop bien dans quelle catégorie d’ingrédients figurer. Le myristate d’isopropyle se plie pourtant en quatre pour complaire aussi bien au formulateur qu’au consommateur. On tiendra compte de son effet « exhausteur de pénétration » et on évitera quand même de l’incorporer dans les produits devant exercer une action de surface ! Lorsque l’on traquera les capitons ou que l’on voudra effacer les rides, on n’aura pas d’état d’âme, le myristate d’isopropyle fera parfaitement l’affaire. Le myristate d’isopropyle entrainera, avec talent, les actifs concernés dans les profondeurs cutanées. On se souviendra enfin de son effet comédogène qui lui fermera les portes d’un certain nombre de formules.