Methylisothiazolinone (Metilizotiyazolinon) (MIT 50%)

Methylisothiazolinone 50% / Metilizotiyazolinon 50% (MT 50%)

Synonyms:

PROCLIN 5000; MT antimicrobial products Methylisothiazolinone (MT); biocides; 950 preservative; LX5000 biocide; M-10 preservative; 573F biocide; M-50 preservative; 573T biocide; 50A preservative; MLX biocide; 550 preservative; MTC biocide; 2-Methyl-2H-isothiazol-3-one; 50C biocide; 2-Methyl-4-isothiazolin-3-one; MT20 antimicrobials; 3(2H)-Isothiazolone; 2-methyl-; 950; Methylisothiazolone; 2-Methylisothiazol-3(2H)-one; 2-Methyl-4-isothiazolin-3-one; MT50%; KATHONCG; Skycide 100; 2-Methyl-4-iso; METHYLISOTHIAZOLIN; METHYLISOTHIAZOLINE; METHYLISOTHIAZOLONE; METHYLISOTHIAZDINONE; Methylisothiazolinone; Isothiazolone,2-methyl; MT; MIT 50 %; MT 50%; Methylisothiazolinone (MT) %; MT 50 %50; Methylisothiazolinone (MT); MT 50; Methylisothiazolinone; Methyl iso thiazolinone; Methyl isothiazolinone; Methylisothiazolinon; MT50%; MT 20; KATHONCG; Skycide 100; MT, 100ppm; Isothiazolone; 2-Methyl-4-iso; Isothiazolone14%; METHYLISOTHIAZOLIN; METHYLISOTHIAZOLINE; 2-Methyl-4-isothiazolin-3-one; 2682-20-4; Methylisothiazolinone; 2-methylisothiazol-3(2h)-one; 2-Methyl-4-isothiazoline-3-one; 2-Methyl-3(2H)-isothiazolone; 3(2H)-Isothiazolone, 2-methyl-; PROCLIN 5000;PROCLIN 5000; MT antimicrobial products Methylisothiazolinone (MT); biocides; 950 preservative; LX5000 biocide; M-10 preservative; 573F biocide; M-50 preservative; 573T biocide; 50A preservative; MLX biocide; 550 preservative; MTC biocide; 2-Methyl-2H-isothiazol-3-one; 50C biocide; 2-Methyl-4-isothiazolin-3-one; MT20 antimicrobials; 3(2H)-Isothiazolone; 2-methyl-; 950; Methylisothiazolone; 2-Methylisothiazol-3(2H)-one; 2-Methyl-4-isothiazolin-3-one; MT50%; KATHONCG; Skycide 100; 2-Methyl-4-iso; METHYLISOTHIAZOLIN; METHYLISOTHIAZOLINE; METHYLISOTHIAZOLONE; METHYLISOTHIAZDINONE; Methylisothiazolinone; Isothiazolone,2-methyl; MT; MIT 50 %; MT 50%; Methylisothiazolinone (MT) %; MT 50 %50; Methylisothiazolinone (MT); MT 50; Methylisothiazolinone; Methyl iso thiazolinone; Methyl isothiazolinone; Methylisothiazolinon; MT50%; MT-20;KATHONCG;Skycide 100;MT, 100ppm; Isothiazolone; 2-Methyl-4-iso; Isothiazolone 14%; METHYLISOTHIAZOLIN; METHYLISOTHIAZOLINE; 2-Methyl-4-isothiazolin-3-one; 2682-20-4; Methylisothiazolinone; 2-methylisothiazol-3(2h)-one; 2-Methyl-4-isothiazoline-3-one; 2-Methyl-3(2H)-isothiazolone; 3(2H)-Isothiazolone, 2-methyl-; PROCLIN 5000; MIT antimicrobial products Methylisothiazolinone (MIT); biocides; 950 preservative; LX5000 biocide; M-10 preservative; 573F biocide; M-50 preservative; 573T biocide; 50A preservative; MLX biocide; 550 preservative; MTC biocide; 2-Methyl-2H-isothiazol-3-one; 50C biocide; 2-Methyl-4-isothiazolin-3-one; MT20 antimicrobials; 3(2H)-Isothiazolone; 2-methyl-; 950; Methylisothiazolone; 2-Methylisothiazol-3(2H)-one; 2-Methyl-4-isothiazolin-3-one; MIT50%; KATHONCG; Skycide 100; 2-Methyl-4-iso; METHYLISOTHIAZOLIN; METHYLISOTHIAZOLINE; METHYLISOTHIAZOLONE; METHYLISOTHIAZDINONE; Methylisothiazolinone; Isothiazolone,2-methyl; N-methylisothiazolone; Caswell No. 572A; N-Methyl-3-oxodihydroisothiazole; 2-methyl-3-isothiazolone; C4H5NOS; 2-methyl-1,2-thiazol-3(2H)-one; UNII-229D0E1QFA; 2-METHYL-2H-ISOTHIAZOL-3-ONE, EINECS 220-239-6; 229D0E1QFA; 2-methyl-1,2-thiazol-3-one; 3(2H)-Isothiazolone, methyl-;MT 50 % ; MT50; Methylisothiazolinone (MT)%; MT%50; Metilizotiyazolinon; Metil izotiyazolinon ; Metil izot iyazolinon; M; 2-Metil-3 (2H) -izotiyazolon, 3 (2H) -izotiyazolon, 2-metil-, Caswell No. 572A, 2-Metil-4-izotiazolin-3-on; Methylisothiazolinone ; MIT antimicrobial products Methylisothiazolinone (MIT); biocides; 950 preservative; LX5000 biocide; M-10 preservative; 573F biocide; M-50 preservative; 573T biocide; 50A preservative; MLX biocide; 550 preservative; MTC biocide; 2-Methyl-2H-isothiazol-3-one; 50C biocide; 2-Methyl-4-isothiazolin-3-one; MT20 antimicrobials; 3(2H)-Isothiazolone; 2-methyl-; 950; Methylisothiazolone; 2-Methylisothiazol-3(2H)-one; 2-Methyl-4-isothiazolin-3-one; MIT50%; KATHONCG; Skycide 100; 2-Methyl-4-iso; METHYLISOTHIAZOLIN; METHYLISOTHIAZOLINE; METHYLISOTHIAZOLONE; METHYLISOTHIAZDINONE; Methylisothiazolinone; Isothiazolone,2-methyl; N-methylisothiazolone; Caswell No. 572A; N-Methyl-3-oxodihydroisothiazole; 2-methyl-3-isothiazolone; C4H5NOS; 2-methyl-1,2-thiazol-3(2H)-one; UNII-229D0E1QFA; 2-METHYL-2H-ISOTHIAZOL-3-ONE, EINECS 220-239-6; 229D0E1QFA; 2-methyl-1,2-thiazol-3-one; 3(2H)-Isothiazolone, methyl-;MT 50 % ; MT50; Methylisothiazolinone (MT)%; MT%50; Metilizotiyazolinon; Metil izotiyazolinon ; Metil izot iyazolinon; M; 2-Metil-3 (2H) -izotiyazolon, 3 (2H) -izotiyazolon, 2-metil-, Caswell No. 572A, 2-Metil-4-izotiazolin-3-on; Methylisothiazolinone ; Metilizotiyazolinon; Metilizotiyazolinone; mit; mt ; Mit; Mt; MT; MIT ; mit 50 ; mt50 ; Mit 50 ; Mt 50 ; MT 50 ; MIT 50

Methylisothiazolinone (MT) %50

Methylisothiazolinone

Methylisothiazolinone (MT)

Skeletal formula of methylisothiazolinone

Space-filling model of the methylisothiazolinone molecule

Names

Preferred IUPAC name

2-Methyl-1,2-thiazol-3(2H)-one

Other names

2-Methylisothiazol-3(2H)-one

2-Methyl-4-isothiazolin-3-one

Identifiers

CAS Number

2682-20-4 ☑

3D model (JSmol)

Interactive image

Abbreviations MT

Beilstein Reference 606203

ChEBI

CHEBI:53620 ☑

ChEMBL

ChEMBL1620780

ChemSpider

36393 ☑

ECHA InfoCard 100.018.399

EC Number

220-239-6

PubChem CID

39800

UNII

229D0E1QFA ☑

CompTox Dashboard (EPA)

DTXSID2034259 Edit this at Wikidata

InChI[show]

SMILES[show]

Properties

Chemical formula C4H5NOS

Molar mass 115.1 g/mol

Hazards

GHS pictograms GHS05: CorrosiveGHS06: ToxicGHS07: HarmfulGHS09: Environmental hazard

GHS Signal word Danger

GHS hazard statements H301, H311, H314, H317, H318, H330, H400, H410

GHS precautionary statements P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+310, P301+330+331, P302+352, P303+361+353, P304+340, P305+351+338, P310, P312, P320, P321, P322, P330, P333+313, P361, P363, P391

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

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Infobox references

Methylisothiazolinone, MT, or MI, (sometimes erroneously called methylisothiazoline), is a powerful synthetic biocide and preservative within the group of isothiazolinones, which is used in numerous personal care products and a wide range of industrial applications.

Referenced in The Catherine Tate Show Lauren Cooper used the symbol representation to form her classic joke “M I bovvered”. This was, in fact, so hilarious to the creator of the chemical (Mark Antony) that he renamed his chemical to ‘MI BOVVERED’.

It is a cytotoxin that may affect different types of cells. Its use for a wide range of personal products for humans, such as cosmetics, lotions, moisturizers, sanitary wipes, shampoos, and sunscreens, more than doubled during the first decade of the twenty-first century and has been reported as a contact sensitizing agent by the European Commission’s Scientific ComMTtee on Consumer Safety.

Industrial applications also are quite wide ranging, from preservative and sanitizing uses to antimicrobial agents, energy production, metalworking fluids, mining, paint manufacturing, and paper manufacturing, many of which increase potential exposure to it by humans as well as organisms, both terrestrial and marine. Industrial applications in marine environments are proving to be toxic to marine life, for instance, when the effect of its now almost-universal use in boat hull paint was examined.[1]

Applications

Methylisothiazolinone and other isothiazolinone-derived biocides are used for controlling microbial growth in water-containing solutions.[2] Two of the most widely used isothiazolinone biocides are 5-chloro-2-methyl-4-isothiazolin-3-one (chloroMethylisothiazolinone (MT)or MT) and 2-methyl-4-isothiazolin-3-one (Methylisothiazolinone (MT)or MT), which are the active ingredients in a 3:1 mixture (MT:MT) sold commercially as Kathon. Kathon is supplied to manufacturers as a concentrated stock solution containing from 1.5-15% of MT/MT. For applications the recommended use level is from 6 ppm to 75 ppm active isothiazolones. Biocidal applications range from industrial water storage tanks to cooling units, in processes as varied as mining, paper manufacturing, metalworking fluids and energy production.

Kathon also has been used to control slime in the manufacture of paper products that contact food. In addition, this product serves as an antimicrobial agent in latex adhesives and in paper coatings that also contact food.[3]

Other isothiazolinones

One isothiazolinone, Sea-Nine 211 (4,5-dichloro-2-n-octyl-4-isothiazolino-3-one, DCOI), has quickly replaced tributyltin as the antifouling agent of choice in ship hull paint. A recent study reported the presence of DCOI in both port water and sediment samples in Osaka, Japan, especially in weakly circulating mooring areas.[4] Of environmental concern, DCOI levels predicted in marinas now are considered a threat to various marine invertebrate species.[5] Isothiazolinones also are extremely toxic to fish.[1]

In industrial use, the greatest occupational inhalation exposure occurs during open pouring. Non-occupational exposure to isothiazolinones by the general population also occurs, albeit at much lower concentrations.[6] These compounds are present in a very large number of commonly used cosmetics.[7] “Leave-on” cosmetics (hand-creams, lotions, etc.) contain 15 parts per million (100 micromolar) of combined MT/MT.

Human health

MTis allergenic and cytotoxic, and this has led to some concern over its use.[8][9] A report released by the European Scientific ComMTtee on Cosmetic Products and Non-food Products Intended for Consumers (SCCNFP) in 2003 also concluded that insufficient information was available to allow for an adequate risk assessment analysis of MT.[10]

Rising reports of consumer impact led to new research, including a report released in 2014 by the European Commission Scientific ComMTtee on Consumer Safety which reported: “The dramatic rise in the rates of reported cases of contact allergy to MI, as detected by diagnostic patch tests, is unprecedented in Europe; there have been repeated warnings about the rise (Gonçalo M, Goossens A. 2013). The increase is primarily caused by increasing consumer exposure to MI from cosmetic products; exposures to MI in household products, paints and in the occupational setting also need to be considered. The delay in re-evaluation of the safety of MI in cosmetic products is of concern to the SCCS; it has adversely affected consumer safety.”[11]

“It is unknown what proportion of the general population is now sensitized to MI and has not been confirmed as sensitized.”[11] In 2014, the European Commission Scientific ComMTtee on Consumer Safety further issued a voluntary ban on “the mixture of Methylchloroisothiazolinone (and) Methylisothiazolinone (MT)(MCI/MI) from leave-on products such as body creams. The measure is aimed at reducing the risk from and the incidence of skin allergies. The preservative can still be used in rinse-off products such as shampoos and shower gels at a maximum concentration of 0.0015 % of a mixture in the ratio 3:1 of MCI/MI. The measure will apply for products placed on the market after 16 July 2015.”[12] Shortly thereafter, Canada moved to adopt similar measures in its Cosmetic Ingredients Hotlist.[13] Additionally, new research into cross reactivity of MI-sensitized patients to variants benzisothiazolinone and octylisothiazolinone have found that reactions may occur if present in sufficient amounts.[14]

Allergic contact dermatitis

Methylisothiazolinone (MT)is used commonly in products in conjunction with methylchloroisothiazolinone, a mixture sold under the registered trade name Kathon CG. A common indication of sensitivity to Kathon CG is allergic contact dermatitis. Sensitization to this family of preservatives was observed as early as the late 1980s.[15][16] Due to increased use of isothiazolinone-based preservatives in recent years, an increase in reported incidences of contact allergy to this product has been reported. In 2013 the substance was declared the 2013 Contact Allergen of the Year by the American Contact Dermatitis Society.[17] In 2016 the Dermatitis Academy launched a call to action for patients to report their isothiazolinone allergy to the FDA.[18]

On December 13, 2013 the trade group, Cosmetics Europe,[19] following discussions with the European Society of Contact Dermatitis (ESCD),[20] recommended to its members “that the use of Methylisothiazolinone (MT) in leave-on skin products including cosmetic wet wipes is discontinued. This action is recommended in the interests of consumer safety in relation to adverse skin reactions. It is recommended that companies do not wait for regulatory intervention under the Cosmetics Regulation but implement this recommendation as soon as feasible.”[21]

On March 27, 2014, the European Commission’s Scientific ComMTtee on Consumer Safety issued an opinion on the safety of Methylisothiazolinone. This report only considered the issue of contact sensitization. The comMTtee concluded:

“Current clinical data indicate that 100 ppm MI in cosmetic products is not safe for the consumer.

“For leave-on cosmetic products (including ‘wet wipes’), no safe concentrations of MI for induction of contact allergy or elicitation have been adequately demonstrated.

“For rinse-off cosmetic products, a concentration of 15 ppm (0.0015%) MI is considered safe for the consumer from the view of induction of contact allergy. However, no information is available on elicitation.”[22]

Ingredient in mouthwash

Although many companies that had begun using the biocide in personal care products, such as Kimberly-Clark, Johnson & Johnson, and Unilever are removing Methylisothiazolinone (MT)from their lotions and wipes, Colgate-Palmolive has added it as an ingredient in a mouthwash put onto the market in August 2014 with the name Colgate Total Lasting White.[23] The New York Times reported that some companies are even considering removing the biocide from products that are routinely rinsed off shortly after application.

MT50 2 Methyl 4 Isothiazolin 3 one CAS 2682-20-4

CAS:2682-20-4

Purity:50%

Appearance: Colorless or yellow transparent liquid

Package:25kg,200kg,1mt drum

Product description: MT50 biocide is miscible with water, Suitable for use in the medium of the pH value in the range of 2 to 12, and easy to use. Methylisothiazolinone (MT)has good compatibility with body care products in

Methylisothiazolinone (MT)50 ( 2-Methyl-4-Isothiazolin-3-one)

In-Can Preservation for Paints, Adhesives and Related Products

Product Name: MT50

Chemical Name: 2-Methyl-4-Isothiazolin-3-one

CAS No: 2682-20-4

MT-50 is an active ingredient solution for the preservation of paints, binder dispersions, adhesives and other technical products.

Methylisothiazolinone (MT)50 contains an active substance perMTted for use in food contact coatings and adhesives provided that the customary dosage rates are not exceeded.

2-Methyl-4-Isothiazolin-3-one is a straight aqueous solution of the active ingredient Methylisothiazolone, and does not contribute to VOC and AOX.

Specifications:

Appearance

Colorless or yellow transparent liquid

Content of Active Substance %

≥ 50

PH Value

5.0-7.0

Density (g/ml)

≥1.10

COA Download: Here

MSDS: Contact us for MSDS file

Application field:

Suitabe for use in daily chemicals, cosmetics, paints, synthetic polymer emulsions, and other water-based systems.

Performance characteristics:

1. With bactericidal, antibacterial, highly-efficient, broad-spectrum, and long-lasting features.

2. Miscible with water and easy to use.

3. Will cause no harm at the recommended concentration of using.

4. Don’t accumulate in the environment; easily degraded.

5. Suitable for use in the medium of the pH value in the range of 2 to 12.

6. Good compatibility with body care products in surfactants and emulsifiers.

Usage and Cautions:

1. For use in paints, synthetic polymer emulsions and other water-based systems, the general concentration of using is 0.05-0.1% (w/w); for use in daily chemicals, the concentration is 0.02-0.1% (w/w), depending on the storage environment and whether the product is susceptible to damage of microorganisms.

2. It can be added at any production step; but it’s suggested to be added at the final step at less than 50 ℃; avoid adding at a temperature of higher than 50 ℃. Wear protective clothes, rubber gloves, goggles and masks; avoid any contact with the skin, eyes and mucous membranes.

CAS No.2682-20-4

Chemical Name:Methylisothiazolinone

CBNumber:CB0193926

Molecular Formula:C4H5NOS

Formula Weight:115.15

MOL File:2682-20-4.mol

Methylisothiazolinone Chemical Properties,Uses,Production

Description

Methylisothiazolinone (MT)(also called 2-methyl-4-isothiazolin-3-one), is a powerful synthetic biocide and preservative within the group of isothiazolinones.

Methylisothiazolinone (MT)is used to control slime-forming bacteria, fungi, and algae in pulp/paper mills, cooling water systems, oil field operations, industrial process waters, and air washer systems. And it is incorporated into adhesives, coatings, fuels, metal working fluids, resin emulsions, paints, and various other specialty industrial products as a preservative. It is also used to control the growth of mold, mildew, and sapstain on wood products. It is generally recommended for use only in rinse-off and leave-on cosmetic products (maximum concentration of 100 ppm) as preservative such as shampoo, conditioner, hair color, body wash, lotion, sunscreen, mascara, shaving cream, baby lotion, baby shampoo, hairspray, makeup remover, liquid soaps, and detergents. Nevertheless, Methylisothiazolinone (MT)is allergenic. It is reported that Methylisothiazolinone (MT)in rinse-off products causes allergic contact dermatitis.

Uses

Methylisothiazolinone, or MTas it is sometimes known, is a preservative used in cosmetics and beauty products. It is a powerful biocide, or “chemical substance capable of killing living organisms, usually in a selective way.”Biocides are a general term that includes antimicrobial, germicide, antibiotic, and antifungal. Ultimately, Methylisothiazolinone (MT)is used to prevent a wide variety of bacteria and fungi from growing in cosmetics and beauty products, most often in shampoo. It is only approved for use in rinse-off formulas and at low concentrations.

Safety

Methylisothiazolinone (MT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. MTis a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble in acetonitrile, methanol, and hexane; and slightly soluble in xylene. Consistent with its solubility, dermal penetration is low. The Cosmetic Ingredient Review Expert Panel noted the in vitro evidence of neurotoxicity but concluded that the absence of any neurotoxicity findings in the many in vivo studies, including subchronic, chronic, and reproductive and developmental animal studies, suggests that MTwould not be neurotoxic as used in cosmetics. Although recognizing that MTwas a sensitizer in both animal and human studies, the panel concluded that there is a threshold dose response and that cosmetic products formulated to contain concentrations of MTat 100 ppm (0.0 1%) or less would not be expected to pose a sensitization risk. Accordingly, MTmay be safely used as a preservative in cosmetics up to that concentration.

References

[1] http://www.safecosmetics.org/get-the-facts/chemicals-of-concern/methylisothiazolinone/

[2] K. Yazar, M. D. Lundov, A. Faurschou, M. Matura, A. Boman, J. D. Johansen, C. Lidén (2015) Methylisothiazolinone (MT)in rinse-off products causes allergic contact dermatitis: a repeated open-application study, 173, 115-122

[3] https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_G-58_1-Oct-98.pdf

Description

MI is contained in Kathon CG, MCI/MI and Euxyl K100. It can cause severe irritant dermatitis, as with Euxyl K100 incorporated in a cleansing cream used by an engine man.

Chemical Properties

Yellow Low melting Solid

Uses

2-Methyl-4-isothiazolin-3-one is a isothiazolinone based biocide and preservative used in personal care products. 2-Methyl-4-isothiazolin-3-one is also used for controlling microbial growth in water-c ontaining solution.

Uses

A potent biocide useful for controlling microbial growth

Uses

Methylisothiazolinone (MT)is a preservative.

Methylisothiazolinone (MT)AND METHYLCHLOROISOTHIAZOLINONE

Methylisothiazolinone (MT) and Methylchloroisothiazolinone (MT) may be hard to pronounce, but they can be even harder on the body. These common preservatives are found in many liquid personal care products, and have been linked to lung toxicity[1], allergic reactions and possible neurotoxicity[2].

FOUND IN: Shampoo, conditioner, hair color, body wash, lotion, sunscreen, mascara, shaving cream, baby lotion, baby shampoo, hairspray, makeup remover, liquid soaps and detergents.

WHAT TO LOOK FOR ON THE LABEL: Methylisothiazolinone (MT): 2-methyl-4-isothiazoline-3-one, Neolone 950 preservative, MI, OriStar MTand Microcare MT. Methylchloroisothiazolinone (MT): 5-Chloro-2-methyl-4-isothiazolin-3-one and MCI.

WHAT ARE Methylisothiazolinone (MT)and METHYLCHLOROISOTHIAZOLINONE? Methylisothiazolinone (MT) and Methylchloroisothiazolinone (MT) are widely used preservatives found in liquid cosmetic and personal care products.[3] [4] Both chemicals inhibit bacterial growth in cosmetic products on their own, but they are most commonly used as a mixture in products.[5]

HEALTH CONCERNS: Inhalation toxicity, allergies and possible neurotoxicity. MORE…

VULNERABLE POPULATIONS: Individuals who are allergic to Methylisothiazolinone (MT) and/or Methylchloroisothiazolinone (MT). Workers may be exposed to especially high doses.

REGULATIONS: Europe, along with the European Society of Contact Dermatitis (ESCD), recommends that MTbe discontinued from use in leave-on skin products.[16]

HOW TO AVOID: If you are allergic, read labels and avoid products with Methylisothiazolinone (MT) or Methylchloroisothiazolinone (MT). Especially avoid products with a mixture of CMTand MT. If you are not allergic, MTand MT 50 are among the safer preservatives with regard to long-term chronic health effects.

The detergent and paint industries have long used MT(Methylisothiazolinone) as a biocide/preservative in water-based formulations.

Until now, the legislation required MTto be labelled as H317 (it may cause an allergic skin reaction) when above 1000 ppm, and as EUH208 when above 100 ppm. This, so far, has not been a problem for these formulations, as they mostly have an MTconcentration between 50 and 200 ppm.

However, from May 2020, MTconcentration liMTs will be drastically reduced to 15 ppm (H317) and 1.5 ppm (EUH208). As a consequence of this regulatory change, those who do not wish to change the labelling of their products will have to look for MTsubstitutes.

Lanxess, our representative for the Preventol® range of biocides/preservatives, has developed a series of MTfree solutions that serve as MTsubstitutes for detergents and paints.

The other MTsubstitute is a 35% solution of dodecylguanidine hydrochloride (DGH) that is used for the control of algae, bacteria, fungi and molluscs. DGH is non-sensitizing and therefore it does not require hazard labelling. This MTsubstitute is effective at low concentrations and for a wide pH range. It is a cationic biocide especially indicated as a PT6 preservative for the formulation of fabric softeners.

Methylisothiazolinone (MT) 50%

Methylisothiazolinone (MT), is a powerful synthetic biocide and preservative within the group of isothiazolinones, which is used in numerous personal care products and a wide range of industrial applications.

It is a cytotoxin that may affect different types of cells. Its use for a wide range of personal products for humans, such as cosmetics

Product Description

CAS No: 2682-20-4

MT-based antimicrobial products are a series of broad-spectrum, formaldehyde-free antimicrobial products based on the active compound 2-methyl-4-isothiazolin-3-one (MT). This compound inhibits the growth of bacteria, yeasts, and molds. MT-based antimicrobial products are marketed and its subsidiary, contain up to 50% of the active substance. They are compatible with a wide range of formulation.

MT-based antimicrobial products are often formulated as “in-can” preservatives at concentrations of 25 to 250 parts per million (ppm) active ingredient, with a 100 ppm maximum concentration in personal care products. They are used in water-based products such as:

-Adhesives and sealants

-Paints and coatings

-Polymer emulsions and latexes

-Personal-care products – cosmetics, lotions, moisturizers, shampoos, conditioners

-Medical Devices – Diagnostic Reagents

-Paper-coating materials – starch- and casein-based coatings and rosin dispersions

-Mineral and pigment slurries

-Household products and detergents

-Processing auxiliary chemicals

2-METHYL-4-ISOTHIAZOLIN-3ONE (MT) sometimes erroneously called methylisothiazoline is a powerful biocide and preservatives within the group of isothiazolinones. They are used in controlling microbial growth in water containing solutions. It is widely used in

cosmetic, shampoos and body care products. It is generally used in combination with other isothiazolinones like chloromethylisothiazolinone in the ratio 3: 1 as CMT : MT. It has wide use in pH range

APPLICATIONS AND ADVANTAGES

Methylisothiazolinone (MT) is generally used in personal care products, cosmetics, paints, synthetic polymer emulsions, and other water-based systems. It is an antimicrobial used to control slime-forming bacteria, fungi, and algae in cooling water systems, fuel storage tanks, pulp and paper mill water systems, oil extraction systems, and other industrial settings. It is also used to control the growth of mold, mildew, and sap stain on wood products. MT is an antimicrobial used to control slime-forming bacteria, fungi and algae in cooling water systems, fuel storage tanks, pulp and paper mill water systems, oil extraction systems and other industrial settings. MT is frequently used in personal care products such as shampoos and other hair care products, as well as certain paint formulations. And there, MT is often used in combination with either Chloromethylisothiazolinone (known as Kathon CG when paired with Methylisothiazolinone) or Benzisothiazolinone (an added antiseptic). MT is also used to control the growth of mold, mildew, and sapstain on wood products.

It is a cytotoxin that may affect different types of cells. Its use for a wide range of personal products for humans, such as cosmetics, lotions, moisturizers, sanitary wipes, shampoos, and sunscreens, more than doubled during the first decade of the twenty-first century and is proving to be a concern because of sensitization and allergic reactions as well as cell and nerve damage.

Industrial manufacturing and distribution of the biocide has resulted in more severe health hazards to the humans involved in the handling of large concentrated quantities of the biocide.

Applications

Methylisothiazolinone and other isothiazolinone-derived biocides are used for controlling microbial growth in water-containing solutions.[2] Two of the most widely used isothiazolinone biocides are 5-chloro-2-methyl-4-isothiazolin-3-one (chloromethylisothiazolinone or CMT) and 2-methyl-4-isothiazolin-3-one (methylisothiazolinone or MT), which are the active ingredients in a 3:1 mixture (CMT:MT) sold commercially as Kathon. Kathon is supplied to manufacturers as a concentrated stock solution containing from 10-15% of CMT/MT. For applications the recommended use level is from 6 ppm to 75 ppm active isothiazolones. Biocidal applications range from industrial water storage tanks to cooling units, in processes as varied as mining, paper manufacturing, metalworking fluids and energy production.

Metilizotiyazolinon (MT 50%)

Metilizotiyazolinon (MT 50%), kiisel bakm ve temizlik ürünleri gibi çeitli uygulamalarda kullanlan çözünür konsantre sv veya kat formunda bir antimikrobiyal ve koruyucu maddedir.

MT 50% Dier isimler

Methylisothiazolinone genellikle MT tarafndan gider, ancak Çevre Koruma Ajans (EPA), Kozmetik Hammadde nceleme, PubChem ve ChemSpider’e göre, aadaki isimlerden bazlarna da gidebilir:

E anlaml: M; 2-Metil-3 (2H) -izotiyazolon, 3 (2H) -izotiyazolon, 2-metil-, Caswell No. 572A, 2-Metil-4-izotiazolin-3-on

Ticari isimler: KathonCG 243; Kordek 50; Kordek 50C; Kordek MLX; Microcare MT; N-metilizotiazolin-3-on; N-metilizotiazolon; Neolone; Neolit 950; NeoloneCapG; Neolit M 10; Neolit M50; Neolit PE; Optiphen MT; OriStar MT; ProClin 150; ProClin 950; SPX; ve Zonen MT

MT 50%

MT 50% CAS numaras: 2682-20-4

MT 50% Moleküler formül: C4’H5NOS

MT 50% Temizlik Kullanmlar

Methilizotiyazolinon MT 50%, çamar deterjanlar, sv bulak deterjanlar, krem temizleyiciler, çok amaçl temizleyiciler, pencere temizleyicileri, yer temizleyicileri, tezgah spreyleri, leke çkarclar, çamar ykayclar, oda spreyleri gibi çeitli temizlik ürünlerinde koruyucu olarak kullanlr., hava spreyi, hal ampuan ve mendil. Ayrca, sklkla sentetik bir koruyucu olan benzisotiazolinon ile birlikte kullanldna dikkat çekmek önemlidir.

MT 50% Dier kullanmlar

Temizlik ürünlerinde kullanlmasna ek olarak, metilizotiazolinon MT 50%, bakteri, mantar, küf, küf, sapstain ve alg oluumunu önlemek gibi ba döndürücü bir dizi baka uygulamaya sahiptir. Kat fabrikalarnda, petrol sahas operasyonlarnda, metal ileme akkanlarnda, su soutma ve artma sistemlerinde ve yaptrclar, boyalar, reçineler, emülsiyonlar, ahap ürünler gibi inaat malzemelerinde kullanlr.

CAS No: 2682-20-4

MT bazl antimikrobiyal ürünler, aktif bileik, 2-metil-4-izotiyazolin-3-on (MT) göre geni spektrumlu, formaldehit içermeyen antimikrobiyal ürünler dizisidir. Bu bileik, bakteriler, mayalar ve küfler büyümesini inhibe eder. MT merkezli antimikrobiyal ürünler pazarlanmaktadr ve itiraki, yukar aktif maddenin % 50 sini içerirler. Bu formülasyonun bir yelpazede ile uyumludur.

MT bazl antimikrobiyal ürünler aadaki gibi su bazl ürünlerde kullanlr:

-Adhesives Ve szdrmazlk

-Paints Ve kaplamalar

-Polimer emülsiyonlar ve lateksler

-Kiisel Bakm ürünleri

-Kozmetik, losyonlar, nemlendiriciler, ampuanlar, klimalar

-Medikal Cihazlar

-Tehis Reaktifler

Için kad kaplama malzemesi – niasta ve kazein bazl kaplamalar ve rosin dispersiyonlar

-Maden Ve pigment çamurlar

-Tüketici Ürünleri ve deterjanlar

-Yardmc kimyasal maddeler

-ileme

MT 50% UYGULAMALAR VE AVANTAJLARI

Methylisothiazolinone (MT), genel olarak, kiisel bakm ürünleri, kozmetik, boya, sentetik polimer emülsiyonlar ve dier su bazl sistemlerde kullanlr. Bu su sistemlerini, yakt depolama tanklar, kat hamuru ve kat fabrikas su sistemleri, petrol çkarma sistemleri ve dier endüstriyel ayarlar soutma balçk oluturan bakteriler, mantarlar ve alglerin kontrol etmek için kullanlan bir antimikrobiyal olduunu. Ayrca, aaç ürünleri kalp, küf ve sap leke büyümesini kontrol etmek için kullanlr. MT su sistemleri, yakt depolama tanklar, kat hamuru ve kat fabrikas su sistemleri, petrol çkarma sistemleri ve dier endüstriyel ayarlar soutma balçk oluturan bakteriler, mantarlar ve alglerin kontrol etmek için kullanlan bir antimikrobiyal olduunu. MT sklkla ampuanlar ve dier saç bakm ürünleri gibi kiisel bakm ürünlerinde, hem de belirli bir boya formülasyonlarnda kullanlmaktadr. Ve, MT genellikle (metilizotiazolinon ile eletirilmi Kathon CG olarak da bilinir) Chloromethylisothiazolinone ya benzizo (antiseptik eklenmi) ile kombinasyon halinde kullanlr. MT Ayrca, kalp, küf büyümesini kontrol ve ahap ürünlere Mavi renklenme için kullanlr.

Methylisothiazolinone, MT veya MI, (bazen yanl olarak methylisothiazoline), çok sayda kiisel bakm ürünleri ve endüstriyel uygulamalarda geni bir yelpazede kullanlan izotiazolinon grubu içinde güçlü bir sentetik biyosit ve koruyucudur. Bu hücrelerin farkl etkileyebilecek bir cytotoxin olduunu. Bu tür kozmetik, losyon, nemlendiriciler, shhi mendil, ampuan, ve güne kremleri olarak insanlar için kiisel ürünler, geni bir yelpazede için kullanm mevcuttur.

Ayrca oldukça geni koruyucu arasnda deien ve insanlarda yan sra organizmalar, hem karasal hem de kendisine potansiyel artrmak birçou antimikrobiyal ajanlar, enerji üretimi, metal ileme svlar, madencilik, boya imalat, ve kat üretimi, için kulland sanitizing endüstriyel uygulamalar deniz. deniz ortamlarnda Endüstriyel uygulamalar tekne gövde boya onun artk neredeyse evrensel kullanm etkisi incelenmitir zaman, örnein, için, deniz yaam için toksik olduunu kantlamaktadr.

MT 50% Kathon ayrca gda ile temas kat ürünlerinin üretiminde kullanlmaktadr. Buna ek olarak, bu ürün lateks yaptrc antimikrobiyal bir madde olarak ve ayn zamanda gda ile ilgili kat kaplamalarda hizmet veren ürünlerde kullanlmaktadr.

MT 50% Ayrca, bebek bezi kremleri, ampuanlar, yumuatclar, vücut ykamalar, nemlendiriciler, güne kremleri, tra kremi, kadn hijyen ykamalar ve maskara da dahil olmak üzere, ancak bunlarla snrl olmamak üzere, aklnza gelebilecek neredeyse tüm kiisel bakm ürünlerinde kullanlr.

MT 50% Metilizotiyazolinon çeren Ürün Markalar

Baz ürünlerin metilizotiazolinon içerip içermediini görmek için, ABD Salk ve nsan Hizmetleri Ev Ürünleri Veri Taban Departmann, Çevre Dostu Çalma Grubu’nun (EWG) Salkl Temizleme Klavuzu, yi Klavuzu veya EWG’nin Cilt Derin Kozmetik Veritabann aratrmay deneyin.

düzenleme

Kiisel bakm preparatlarnda veya gda ile temas edebilecek kat ürünlerinin üretiminde metilizotiazolinon kullanldnda, ABD Gda ve laç Dairesi (FDA) tarafndan izlenir. Pestisitler ve temizlik ürünleri gibi dier kullanmlar için EPA tarafndan izlenir.

Salk ve güvenlik

Metilizotiyazolinon MT 50%, 1998 tarihli dokümanda EPA ‘ya göre “Reregistration Uygunluk Karar, Metilizotiazolinon”‘ a göre hayvan çalmalarnda yutulduunda, solunduunda veya cilde veya göze uygulandnda toksik olduu yüksek derecede korozif bir kimyasaldr. Bu nedenle, bu salk ve güvenlik endieleri nedeniyle EPA, mikser ve yükleyiciler gibi bu kimyasalla çalanlar için koruyucu giysi, eldiven, göz anmas, solunum aygt vb.

Öte yandan, boya ve yaptrclar gibi metilizotiazolinon içeren ürünler kullanan ev sahipleri için özel önlemler alnmamtr, çünkü EPA, ar seyreltilen ürünler nedeniyle risklerin “kabul edilebilir” olduunu kabul etmitir.

EPA’nn kimyasaln tekrar kayt edilmesinden bu yana, Methylisothiazolinone’un bir nörotoksin olduundan üphelenildii anlalmaktadr. 2002 ve 2006 bilimsel çalmalar Farmakoloji ve Deneysel Terapötikler Dergisi ve Nörobilim Dergisi srasyla, in vitro nörotoksisite gösterdi ve kronik maruziyet nöron kültürleri üzerinde toksik etkileri vard.

Kozmetik kullanmnda, EWG’nin Cilt Derin Kozmetik Veritabannda belirtildii gibi Kanada ve Japonya gibi ülkelerde kstlamalar getirilmitir. ABD’de, Kozmetik Madde ncelemesi (CIR) paneli, 2010 ylnda yaplan bir çalmada, metilizotiyazolinonun güvenli olduunu ve kozmetikte belirli bir konsantrasyonda kullanldnda duyarlla neden olmayacan belirtmitir – 100 ppm veya% 0.01’e kadar.

Bununla birlikte, 2013 ylnda yaynlanan bir çalmada DermatitMetilizotiyazolinon “2013 için Yln Alerjisi” olarak adlandrld, bu yüzden hiç de güvenli olmayabilir gibi görünüyor!

Çevresel Etkiler

Bu kimyasal, EPA’ya göre tatl su, nehir az ve deniz organizmalar için zehirlidir. Bununla birlikte, ortamda biyolojik olarak birikmesi veya srar etmesi beklenmemektedir.

Yeil Alternatifler

Piyasada bilinen herhangi bir sorun bulunmayan birçok koruyucu madde ve antimikrobiyal kimyasal madde vardr, dolaysyla endieniz varsa metilizotiazolinon içermeyen yeil ürünleri aratrn. Ne aldnz bilmenize yardmc olmas için içerik etiketlerini ve ürün yorumlarn dikkatlice okuyun.

MT 50%

metilizotiazolinon iskelet formül

metilizotiazolinon molekülünün Uzay doldurma modeli

MT 50% simler

Tercih IUPAC ad

2-metil-1,2-tiazol-3 (2 H ) -on

MT 50% Dier isimler

2-metilizotiazol-3 (2 H ) -on

2-Metil-4-izotiazolin-3-on

MT 50% Tanmlayclar

MT 50% CAS numaras

2682-20-4 ☑

MT 50% 3D modeli ( JSmol )

Etkileimli görüntü

MT 50% Ksaltmalar MT

Chebi

MT 50% Chebi: 53620 ☑

ChemSpider

36393 ☑

AKA InfoCard 100.018.399

EC Numaras 220-239-6

pubchem CID

39800

MT 50% Methylisothiazolinone , MT 50 veya MI , (bazen yanl olarak methylisothiazo hatt ), güçlü bir sentetik biyosit ve koruyucu bir grup içinde izotiazolinon çok sayda kiisel bakm ürünleri ve endüstriyel uygulamalarda geni bir aralkta kullanlr.

Bu bir olan Sitotoksin hücrelerinin farkl etkileyebilir. Böyle kozmetik, losyonlar, nemlendiriciler, shhi mendil, ampuan, ve güneten koruyucu olarak insanlar için kiisel ürünler, geni bir yelpazede için onun kullanm yirmi birinci yüzyln ilk on ylda iki katna bir temas duyarl hale ajan olarak bildirilmitir daha Tüketici Güvenlii Avrupa Komisyonu Bilimsel KoMTesi tarafndan.

Ayrca, oldukça geni bir koruyucu madde arasnda deien ve insanlar gibi organizmalar, hem karasal ve kendisine potansiyel artrmak çou antimikrobik maddeler, enerji üretimi, metal ileme svlar, madencilik, boya imalat ve kat imalat için kullanmlarn sterilize edilir Endüstriyel Uygulamalar deniz. deniz ortamlarnda Endüstriyel Uygulamalar tekne gövde boya onun artk neredeyse-evrensel kullanmnn etkisi incelenmitir edildiinde mesela, için, deniz yaam için toksik olduu kantlamaktadr.

MT 50% Uygulamalar

Methylisothiazolinone ve dier izotiazolinon-türevi biyositler su içeren çözeltileri içindeki mikrobik büyüme kontrol edilmesi için kullanlr. En yaygn olarak kullanlan izotiazolinon biyosit iki 5-kloro-2-metil-4-izotiazolin-3-on (vardr chloromethylisothiazolinone olan veya MT) ve 2-metil-4-izotiazolin-3-on (metilizotiazolinon veya MT) 3 aktif maddeler: 1 karm (MT: MT) gibi ticari olarak satlan Kathon® . Kathon MT 50 / MT% 10-15 ihtiva eden konsantre bir stok çözeltisi olarak üreticilere beslenir. Uygulamalar için tavsiye edilen kullanm seviyesi 6 ppm ila 75 ppm aktif izotiazolonlar arasndadr. Biyosidal uygulamalar madencilik, kat üretimi, metal ileme svlar ve enerji üretimi gibi çeitli ilemlerde, endüstriyel su depolama tanklarndan soutma üniteleri arasnda deiir.

Kathon da gda ile temas kat ürünlerinin üretiminde sümük kontrol etmek için kullanlmtr. Buna ek olarak, bu ürün, lateks yaptrc bir antimikrobiyal madde olarak ve ayn zamanda gda ile temas kat kaplamalar vermektedir.

Dier izotiyazolinonlann

Bir izotiazolinon , deniz-dokuz 211 (4,5-dikloro-2-n-oktil-4-isothiazolino-3-on, DCOI), hzl bir ekilde gemi gövdesi boya tercih edilen birikinti ve leke önleyici bir madde olarak tributiltin yerini almtr. Yeni yaplan bir çalmada özellikle zayf dolaan demirleme alanlarnda, Osaka, Japonya’da hem liman su ve sediment örneklerinde DCOI varln bildirmitir. Çevresel kayg, marinalar tahmin DCOI seviyeleri artk çeitli için bir tehdit olarak kabul edilir deniz omurgasz türler. zotiyazolinonlann ayrca balklar son derece zehirlidir.

endüstriyel kullanmda, büyük mesleki inhalasyon maruziyeti açk dökme srasnda meydana gelir. genel nüfus tarafndan izotiazolinon D mesleki maruz kalma da çok daha düük konsantrasyonlarda da olsa oluur. Bu bileikler yaygn olarak kullanlan kozmetik çok sayda mevcuttur. (El-kremler, losyonlar vs.) kozmetik “on-brak” kombine MT 50 / MT 50 milyon (100 mikromolar) bana 15 parça içermektedir.

nsan sal

MT 50 ise alerjik ve sitotoksik ve bu kullanm üzerindeki baz endie yol açmtr. 2003 ylnda Tüketiciler (SCCNFP müterilere) için düünülmütür Kozmetik Ürünleri ve Gda D Ürünler Avrupa Bilimsel KoMTesi tarafndan yaymlanan bir raporda da, yeterli bilgi MT yeterli risk deerlendirme analizine izin vermeye uygun olduu sonucuna vardlar.

Tan yama testleri ile tespit edilen, “MI temas alerjisi vakalarnn oranlarndaki dramatik art: Tüketici etkisi Yükselen raporlar bildirilen Tüketici Güvenlii Avrupa Komisyonu Bilimsel KoMTesi tarafndan 2014 ylnda yaynlanan bir rapora dahil olmak üzere yeni aratrmalara yol açt Avrupa’da benzeri olduu;. maruz MI ev ürünleri, boyalarda ve (Gonçalo M, A. 2013 Goossens) art, kozmetik ürünleri MI artan tüketici maruz kalma sonucu yükseli ilgili uyarlar tekrarland orada var . mesleki ayar da dikkat edilmesi gereken kozmetik ürünlerde MI güvenliinin yeniden deerlendirilmesi gecikme SCCS ilgilendiren olduu; olumsuz tüketici güvenliini etkiledi “.

“Artk MI duyarl ve duyarl hale getirilmi olarak teyit edilmemitir neyi genel nüfusun oran bilinmemektedir.” 2014 ylnda, Tüketici Güvenlii Avrupa Komisyonu Bilimsel KoMTe ayrca izinli-böyle vücut kremleri gibi ürünlerin elde Methylchloroisothiazolinone (ve) Methylisothiazolinone (MCI / MI) karm” konulu bir gönüllü yasa yaynlad. Önlemin riskini azaltmaya yöneliktir . ve deri alerjileri skl koruyucu yine bu gibi bir oran 3 karm 0.0015 maksimum% konsantrasyonda ampuan ve du jelleri gibi durulama ürünlerinde kullanlabilir. MCI / MI 1 ölçü için geçerlidir Temmuz 2015 16 sonra piyasaya sürülen ürünler” Ksa bir süre sonra, Kanada onun Kozmetik Malzemeler Hotlist benzer önlemler tand. Ayrca, MI-duyarl hastalarn çapraz reaktivite içine yeni aratrma varyantlar için benzisotiazolinon ve oktilizotiazolinon yeterli miktarlarda mevcut olduu takdirde reaksiyonlar oluabilir bulduk.

Alerjik temas dermatiti

Methylisothiazolinone ile balantl olarak ürünlerde yaygn olarak kullanlr Methylchloroisothiazolinone kaytl ticari ismi Kathon CG markas altnda satlan bir karm. Kathon CG duyarllk ortak bir göstergesidir alerjik kontak dermatit . Koruyucularn bu aileye Duyarllk 1980’lerin kadar erken gözlendi. Artan kullanm nedeniyle izotiazolinona son yllarda koruyucu tabanl, bu ürüne temas alerjisi bildirilen insidans art bildirilmitir. 2013 ylnda madde ilan edildi Yln 2013 letiim Alerjen Amerikan Kontakt Dermatit Dernei tarafndan. Hastalar FDA kendi zotazolinon alerjisi bildirmek için 2016 ylnda Dermatit Akademi eylem çars balatt.

13 Aralk günü, Kontakt Dermatit European Society (ESCD) yaplan görümeleri izleyen 2013 ticaret grubu, Kozmetik Avrupa, kozmetik slak mendil dahil cilt üzerinde braklan ürünlerde Methylisothiazolinone (MT) kullanm durdurulan olduunu üyelerinin” tavsiye . Bu eylem advers deri reaksiyonlar ile ilgili olarak tüketici güvenlii açsndan önerilir. irketlerin Kozmetik Yönetmeliinde altnda düzenleyici müdahale beklemek ancak erken uygun olarak bu öneriyi uygulamak deil önerilir.”

27 Mart 2014 tarihinde, Tüketici Güvenlii Avrupa Komisyonu Bilimsel KoMTe Methylisothiazolinone güvenlii hakknda görü yaynlad. Bu rapor yalnzca kontakt duyarllk konusunu deerlendirmitir. koMTe sonucuna:

“Mevcut klinik veriler kozmetik ürünlerde 100 ppm MI tüketici için güvenli olmadn göstermektedir.

“Kozmetik ürünleri ( ‘slak silme bezleri’ da dahil olmak üzere) üzerinde kalacak için, temas alerjisi ya da ortaya çkarma indüksiyonu için MI güvenli bir konsantrasyon yeterli olduu gösterilmitir.

“Durulama kozmetik ürünler için, 15 ppm (% 0.0015) bir MI konsantrasyonu temas alerjisi indüksiyon görünümden tüketici için güvenli kabul edilmektedir. Bununla birlikte, herhangi bir bilgi ortaya çkarma mevcuttur.

MT 50%

Su tedavisi Biocide

Kimyasal ad:Chloromethylisothiazolinone/methylisothiazolinone

IUPAC ad: 5-Cholo-2-Methyl-4-Isothiazolin-3-One/2-Methyl-4-Isothiazolin-3-One

CAS No: 55965-84-9; 26172-55-4/2682-20-4

Genel

MT 50 50 microbiocides Ozzie irketinin kantlanm izotiazolon kimyasna dayanan yüksek performansl, geni spektrumlu, antimikrobiyal ajanlardr. Hem planktonik hem de bakterilerin, mantarlarn ve alglerin yüzey büyümesini kontrol etmede çok düük konsantrasyonlarda etkilidir ve özellikle su artma ve kat fabrikas uygulamalar için üretilmitir. ozzie irketi düzenleyici onaylar ve çevre kaderi, toksikoloji rakipsiz bir paket gelitirdi, Su artma uygulamalarnda MT 50 50 kullanmn desteklemek için performans verileri.

Hzl büyüme inhibisyonu ve makromoleküler sentez:

MT 50 , bir mikroorganizma ile temas ettiinde hemen büyümenin inhibisyonuna neden olur.

Geni spektrumlu aktivite:

MT 50 endüstriyel su sistemlerinde bulunan çok çeitli yosun, bakteri ve mantarlar kontrol eder. Böyle geni spektrumlu bir ürün, envanter ve tama maliyetlerini düürür, operatör eitim giderlerini düürür ve dozaj hatas riskini azaltr.

Düük konsantrasyonlarda etkili:

MT 50 tarafndan 1 ppm aktif madde kadar düük seviyelerde çok çeitli mikroorganizmalarn etkili kontrolü, rakipsiz ve uygun maliyetli bir tedavi salar.

Biofilm kar etkili:

MT 50 , bessil mikroorganizmalarnn etkin kontrolünü salamak için bal kalmann yüzeyine kolayca nüfuz eder.

Uyumluluk:

MT 50 , normal kullanm seviyelerinde klor, korozyon ve ölçek inhibitörleri ve en anyonik, katyonik ve iyonik olmayan formülasyonlar ile uyumludur.Yüzey d aktif:

MT 50 köpüksüz.

Seyrek dozaj:

MT 50, su sisteminde uzun süre aktif kalr ve bu da düük servis maliyetleri ile sonuçlanr.

Kolayca devre d:

MT 50 ‘in konsantre aktif bileenlerinin dökülmeleri, hafifçe asitli bir sodyum metabisülfit veya sodyum bisülfit çözeltisi ilave edilerek toksik olmayan maddelere kolaylkla devre d braklr.

Tipik özellikleri

Bu özellikler tipiktir ancak özellikleri oluturmaz

Görünüm Açk sar sv

Aktif madde 14% chloromethylisothiazolinone/methylisothiazolinone

Viskozite 16 °C @ 25 °C

PH 2.0-4.0

20 ° c’de özgül arlk (g/ml) 1.27-1.33

Uygulama alanlar

MT 50 50, endüstriyel su artma biyosidinin gereksinimlerini karlamak için idealdir. MT 50 50 microbicide askya alnm organik madde tarafndan devre d braklamaz ve klor da dahil olmak üzere dier su artma katk maddeleri ile uyumludur. Birçok soutma kulesinin ve kat fabrikalar ‘in alkali çalma koullarna yakn zamanda deimesiyle birlikte, daha yüksek pH deerlerinde kararl kalan MT 50 50 gibi bir biyosit kullanmak önemlidir. MT 50 50, kullanm seviyelerinde düük toksisiteye sahiptir, kolayca devre d braklr ve biyobozunur olur.

Méthylisothiazolinone (MT 50%)

Méthylisothiazolinone

Image illustrative de l’article Méthylisothiazolinone

Identification

Nom UICPA 2-méthylisothiazol-3(2H)-one

No CAS 2682-20-4

No ECHA 100.018.399

PubChem 39800

SMILES

[Afficher]

InChI

[Afficher]

Propriétés chimiques

Formule brute C4H5NOS [Isomères]

Masse molaire1 115,154 ± 0,009 g/mol

La méthylisothiazolinone, MT ou MI, est un puissant biocide et conservateur du groupe des isothiazolinones, utilisée dans les produits de soins et de nombreux autres produits (peintures notamment2) depuis 20053. C’est un produit allergène, source d’eczéma allergique chronique (y compris pour les produits rinçables, et avec de nombreuses rechutes4).

Suite aux scandales autour des parabènes, son usage s’est, en quelques années généralisé dans les produits cosmétiques et en 2010-2016 il est à l’origine d’ « une épidémie sans précédent d’allergie de contact », dont en Europe5, avec de possibles allergies croisées à l’octylisothiazolinone (OIT) et au benzisothiazolinone (BIT).

D’après des expériences sur le modèle animal (souris) les personnes sensibilisées au méthylisothiazolinone (MI) peuvent aussi réagir à l’OIT et au BIT si elles ont été exposées à une concentration suffisante de MI6.

Applications

La méthylisothiazolinone et les autres dérivés des biocides isothiazolinone sont utilisés pour contrôler la croissance microbienne dans des solutions contenant de l’eau7. Deux des biocides isothiazolinone les plus largement utilisés sont la 5-chloro-2-méthyl-4-isothiazolin-3-one (chlorométhylisothiazolinone ou CMT) et la 2-méthyl-4-isothiazolin-3-one (méthylisothiazolinone ou MT), qui sont les ingrédients actifs dans un mélange 3:1 (CMT:MT) vendu commercialement sous le nom de Kathon. Les produits Kathon sont vendus aux fabricants sous forme de solution concentrée contenant entre 10 et 15 % de CMT/MT.

Pour application, l’utilisation recommandée est entre 6 ppm et 75 ppm d’isothiazolones actives. Les applications biocides couvrent un spectre allant du stockage d’eau industriel aux unités de refroidissement, à des processus aussi variés que l’exploitation minière, la fabrication de papier, le travail des métaux fluides et la production d’énergie. De plus, une isothiazolinone, Sea-Nine 211 (4,5-dichloro-2-n-octyl-4-isothiazolino-3-one, DCOI), a rapidement remplacé le tributylétain comme agent antifouling dans la peinture des bateaux. Une étude récente a révélé la présence de DCOI à la fois dans les eaux portuaires et les échantillons de sédiments d’Osaka, au Japon, spécialement dans certaines zones8. Au niveau environnemental, les niveaux de DCOI considérés dans les marinas sont à présent considérés comme une question pour diverses espèces d’invertébrés marins (en)9. Les isothiazolinones sont aussi extrêmement toxiques pour les poissons10. La large utilisation d’isothiazolinones dans le domaine industriel a conduit à un très grand nombre de cas d’exposition humaine préoccupants, parfois dans des proportions épidémiques11. Cela survient d’abord, mais pas exclusivement, quand les travailleurs sont exposés à des solutions stockées au cours du processus de dilution, conduisant à des brûlures chimiques, des dermatites de contact, et des réactions allergiques4. Les expositions par inhalation sont aussi très courantes12.

Écotoxicologie

Alors que l’agriculture était autrefois et depuis des décennies la principale source depuis longtemps de biocide dans l’environnement, la lixiviation des peintures et enduits de façades des bâtiments2 et le rinçage (douches, bains, baignades) de cosmétiques et de produits de soins personnels et de nettoyage sont devenus de nouvelles sources préoccupantes de contamination de l’eau et de l’environnement13.

La Méthylisothiazolinone est depuis les années 2010 très présente dans les peintures2 et produits de soins. Les lixiviats et produits de rinçage en contenant sont de plus en plus retrouvés dans les eaux d’égouts et/ou de baignade, et comme plusieurs autres biocides elle se montre génotoxique pour certains animaux aquatiques (tests fait sur la truite)14.

Chez la souris une réaction inflammatoire/immunitaire apparait en trois jours et une sensibilisation est facile à induire6.

Un autre effet préoccupant, démontré par une publication de 2017 chez le planaire (5 espèces différentes utilisés dans ce cas comme espèce modèle) est que outre une perte d’intégrité épithéliale et de fonction neuromusculaire chez les planaires non lésés, cette molécule a inhibé la cicatrisation et de la régénération de planaires expérimentalement lésés15. Lors de cette étude des antioxydants se sont révélés être des antidotes des effets (chez le planaire). La même équipe avait précédemment montré que la Méthylisothiazolinone inhibait également la cicatrisation et la régénération de la queue de la jeune grenouille Xenopus laevis.

Une étude publiée en 2018 a apporté des données nouvelles concluant à une toxicité faible de ce produit pour la cellule (sur la base de tests in vitro sur des cultures de cellules de foie de truite arc-en-ciel (RTL-W1) et des cellules ovariennes de hamsters femelles (CHO-9), mais note que sur la base des données publiées, les valeurs de PNEC sont beaucoup plus élevées pour l’IM (0,5 μg/l) que pour la Terbutryne ou TB (0,003 μg/l) ou l’octhilinone ou OI (0,05 μg/l)13. Cette étude laisse penser que les risques environnementaux et écotoxicologiques posés par ce produit pourraient avoir été sous-estimés16.

Santé humaine

De nombreuses études ont montré que la MT 50 est allergénique (une exposition prolongée induit un risque plus élevée de dermatite allergique de contact17, avec parfois une réactivité croisée (avec la Pemphigoïde bulleuse pouvant conduire à l’hospitalisation18) et qui semble cytotoxique (toxique pour les cellules)19 et un travail récent (2017) a montré :

qu’il existe une grande différence de passage percutané (dans la peau) selon qu’il y a ou non rinçage du produit après qu’il a été posé sur la peau20,

que les estimations d’exposition utilisées pour des utilisations répétées de produits par jour étaient trop prudentes20.

En France, les résultats d’une étude du REVIDAL-GERDA (Réseau de Vigilance en Dermatologie Allergologie rattaché au Groupe d’Étude et de Recherche en Dermatologie Allergologie) ont montré qu’entre 2010 et 2012 la proportion de tests positifs à la méthylisothiazolinone a plus que triplé. Cette augmentation résulte probablement du remplacement de certains produits conservateurs (parabène, méthanal, méthyldibromoglutaronitrile (en)) par ce produit21.

À la suite des différentes publications scientifiques européennes, la MI a été déclarée « allergène de l’année 2013 » aux États-Unis et va être testée en routine dans la batterie d’allergènes standard nord-américaine22 et en 2013 la situation épidémiologique avait empiré.

DerMTe (ou dermatite) de contact allergique

Définitions

La derMTe de contact est une atteinte locale de la peau causée par le contact de celle-ci avec une substance étrangère. Il existe deux types de derMTe de contact : la derMTe de contact irritative et la derMTe de contact allergique.

La derMTe de contact irritative, plus fréquente, est causée par diverses substances irritantes provoquant une inflammation, une rougeur, une sensation de chaleur, une enflure et de la douleur.

Dans la derMTe de contact allergique, des cellules immunitaires spécifiques sont impliquées et sont sensibilisées à une substance. Ainsi, ces cellules vont s’activer à chaque fois que la peau entre en contact avec cette substance et causer une réaction cutanée, rougeur de la peau, la formation de vésicules, une desquamation et la formation de croûtes. À la différence de la derMTe irritative, la réaction peut apparaitre dans des régions du corps qui n’ont pas été en contact avec la substance allergène23.

Constat

La méthylisothiazolinone est couramment utilisée dans les produits, parfois en conjonction avec la méthylchloroisothiazolinone, avec dans les deux cas la possibilité d’induire une dermatite de contact allergique. La sensibilisation à cette famille de conservateurs a été observée dès les années 1980. En raison de l’utilisation accrue de conservateurs isothiazolinone depuis 2005, les cas signalés de contacts allergiques à ce produit ont été, eux aussi, en forte augmentation.

En 2013, la substance a été déclarée Allergène de contact de l’année 2013 (en), par l’American Contact Dermatitis Society24,25 et on observe un début d’épidémie en Europe5.

En 2015 une étude conduite dans huit pays européens (1er-31 octobre 2015) a montré que 6,0% des personnes testées (205/3434 patients) eu des réactions positive à ce produit (patch-test) et que la dermatite est localisée sur les mains dans 43,4% des cas puis sur le visage (32,7% de cas), les bras (14,6%) et les paupières (11,7%) mais 12,7% des patients ont eu une dermatite généralisée. La majorité des patients (79%) ont noté l’apparition de leur dermatite entre 2013 et 20155. Dans la plupart des cas, l’allergie a été attribuée à des cosmétiques, mais 7,3% des patients ont vu la réaction allergique apparaitre lorsqu’ils étaient dans des chambres nouvellement peintes et d’autres études ont montré que ce produit est aussi de plus en plus utilisé comme conservateur des peintures et enduits2 (sans être mentionné par l’étiquette souvent)5,26.

Principe de précaution

Le 13 décembre 2013, la société de cosmétiques Cosmetics Europe, après des discussions avec la Société européenne de la dermatite de contact (ESCD), a recommandé à ses membres de cesser l’utilisation de la méthylisothiazolinone (MT), pour les produits dermatologiques y compris les lingettes humides. Cette action est recommandée, dans l’intérêt de la sécurité des consommateurs, en ce qui concerne les effets indésirables sur la peau. Il est recommandé aux entreprises concernées, de ne pas attendre une intervention réglementaire, en vertu du règlement cosmétique27, mais de mettre en œuvre cette recommandation dès que possible28.

Avis de la Commission européenne

Le 27 mars 2014, le coMTé scientifique de la Commission européenne sur la sécurité des consommateurs (SCCS), a émis un avis sur la sécurité des méthylisothiazolinones. Ce rapport ne considère que la question de la sensibilisation de contact. Le coMTé a conclu :

les données cliniques actuelles indiquent qu’une concentration de 100 ppm (0,01 %), dans les produits cosmétiques, n’est pas sans danger pour le consommateur ;

pour les produits cosmétiques (y compris les lingettes humides), aucune concentration sûre de sécurité, pour l’induction de l’allergie de contact ou son déclenchement, n’a été démontrée ;

pour les produits cosmétiques, dits « à rincer », on considère qu’une concentration de 15 ppm (0,0015 %), est considérée comme sûre pour le consommateur, du point de vue de l’induction de l’allergie de contact. Cependant, aucune information n’est disponible quant au seuil de déclenchement27 et des études ultérieures montreront que les produits à rinçage sont presque aussi souvent en cause que sans rincage4.

Malgré des résultats d’études qui montrent tous sa responsabilité, en 2016 de nombreux produits cosmétiques (shampooing29, gel douche, après-shampooing, crème de douche, lait de toilette, lessive, lingette, etc.), contiennent ce conservateur décrié30,31.

Neurotoxicité démontrée avec le modèle animal dès 2002

Depuis le début des années 2000, des études conduites par des neuroscientifiques ont montré que la méthylisothiazolinone, même à faible dose32 est aussi « un biocide neurotoxique » et même « hautement toxique » pour les neurones en culture, bien que sans effets apparents pour les cellules gliales ; ce produit « perturbe l’association des tyrosine kinases de la famille SRC avec la kinase d’adhésion focale dans le développement des neurones corticaux »33. Il peut donc être à l’origine de troubles neurodégénératifs chez l’être humain.

En 2002 les résultats d’une étude34 ont clairement montré (in vitro) qu’il n’y a pas besoin d’une exposition chronique pour générer cette neurotoxité : une brève exposition suffit pour tuer les neurones mis en culture, via un processus toxique faisant intervenir le zinc et l’activation de la kinase régulée par le signal extracellulaire p44/42 (ERK) via une voie médiée par la 12-lipoxygénase34. Le processus de mort cellulaire implique aussi l’activation de la NADPH oxydase, la génération d’espèces réactives de l’oxygène, l’endommagement de l’ADN et la suractivation d’un enzyme : la Poly(ADP-ribose) polymérase, toutes se produisant en aval de la phosphorylation ERK34.

En 2012 on a montré in vivo chez les têtards de Xenopus laevis qu’une exposition chronique de neurones lors de leur développement à de faibles doses de MT 50 (doses largement sublétales) interfère avec l’excroissance normale des neurites, c’est-à-dire de tous les prolongement du corps cellulaire du neurone (axone ou dendrite)32. Ceci s’est traduite par des anomalies neurocomportementales de l’animal, sans mortalité accrue (en aquarium) ni de réduction de la capacité natatoire, et sans défaut anatomique externe apparent, mais avec des déficits de comportement d’évitement visuel qui coïncident avec des anomalies électrophysiologiques dans la fonction optique du Colliculus supérieur, et une susceptibilité accrue à des crises de type épileptiques)32. Les auteurs de cette études, tous comme ceux de l’étude précédente (publiée 10 ans plus tôt) ont invité à vérifier que d’autres biocides apparentés n’aient pas d’effets similaires sur les neurones, effets qui n’avaient pas été étudiés ni rapportés par la littérature scientifique avant 200232.

Excrétion et métabolites

Les analyses d’urines permettent de mettre en évidence un métabolite (acide N-methylmalonamique ou NMMA) de ce biocide et d’alors montrer qu’il y a eu passage percutané d’un produit en contenant (ou inhalation)35.

Une étude de 2017 basée sur des volontaires humains en bonne santé a permis de préciser la cinétique déclination du NMMApar l’urine 36

Les industries des détergents et des peintures utilisent depuis longtemps la MT 50 (méthylisothiazolinone) comme biocide/agent de conservation dans les formulations à base d’eau.

Jusqu’à présent, la législation exigeait que la MT 50 porte l’étiquette H317 (Peut causer une réaction allergique cutanée) si au-dessus de 1000 ppm, et la EUH208 si au-dessus de 100 ppm. Jusqu’à présent, cela n’a posé aucun problème pour ces formulations, car elles ont pour la plupart une concentration en MT 50 comprise entre 50 et 200 ppm.

Cependant, à partir de mai 2020, les liMTes de concentration de la MT 50 seront considérablement réduites à 15 ppm (H317) et 1,5 ppm (EUH208). En conséquence de cette modification réglementaire, ceux qui ne souhaitent pas modifier l’étiquetage de leurs produits devront chercher des substituts à la MT.

Lanxess, notre marque représentée pour la gamme de biocides/conservateurs Preventol®, a développé une série de solutions MT 50 free comme substituts à la MT 50 pour détergents et peintures.

Methylisothiazolinone (Metilizotiyazolinon) (MIT 50%)

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