METHYLPARABEN (METLPARABEN)

METHYLPARABEN (METLPARABEN)

METHYLPARABEN (METLPARABEN)

 

CAS Number:99-76-3 
EC Number:202-785-7

SYNONMYS:

4-hydroxy methyl ester benzoic acid; methyl 4-hydroxybenzoate; 4-HYDROXYBENZOIC ACID, METHYL ESTER; 4-HYDROXYBENZOIC ACID, METHYL ESTER, POTASSIUM SALT; BENZOIC ACID, 4-HYDROXY-, METHYL ESTER; BENZOIC ACID, 4-HYDROXY-, METHYL ESTER, POTASSIUM SALT; BENZOIC ACID, 4-HYDROXY-, METHYL ESTER, SODIUM SALT; BENZOIC ACID, 4HYDROXY, METHYL ESTER; BENZOIC ACID, 4HYDROXY, METHYL ESTER, SODIUM SALT; METHYL 4-HYDROXYBENZOATE; METHYL ESTER 4-HYDROXYBENZOIC ACID; METHYL ESTER BENZOIC ACID, 4-HYDROXY-; 4-hydroxybenzoic acid methyl ester; methyl p-hydroxybenzoate; methyl-4-hydroxybenzoate; methylparaben; methylparaben, sodium salt; Nipagin; Methyl 4-hydroxybenzoate; METHYLPARABEN; 99-76-3; Methyl paraben; Methyl p-hydroxybenzoate;Methyl parahydroxybenzoate;Maseptol; p-Hydroxybenzoic acid methyl ester; p-Carbomethoxyphenol; Tegosept M; 4-Hydroxybenzoic acid methyl ester; Methaben; Metoxyde;Preserval; Metaben; Moldex; p- Methoxycarbonylphenol; Paridol; Septos; Solbrol; Methyl parasept; Methyl butex; Methyl chemosept; Nipagin M; Benzoic acid, 4-hydroxy-, methyl ester; Aseptoform; Methylben; Abiol; Preserval M; Solbrol M; Methyl-p-hydroxybenzoate; 4-(Methoxycarbonyl)phenol; Methyl p-oxybenzoate; 4-Hydroxybenzoic acid,; methyl ester; Methyl ester of p-hydroxybenzoic acid; p-Oxybenzoesauremethylester; FEMA No. 2710; Caswell No. 573PP; Benzoic acid, p-hydroxy-, methyl ester; FEMA Number 2710; UNII-A2I8C7HI9T; NSC 3827; p-Hydroxybenzoic acid, methyl ester; p-Hydroxybenzoic methyl ester; CCRIS 3946; HSDB 1184; p- Oxybenzoesauremethylester [German]; EINECS 202-785-7; Methylester kyseliny p-hydroxybenzoove; EPA Pesticide Chemical Code 061201; BRN 0509801; A2I8C7HI9T METHYL4-HYDROXYBENZOATE; 4-HYDROXY-BENZOIC ACID METHYL ESTER; AI3-01336; CHEMBL325372; CHEBI:31835; Methylester kyseliny p-hydroxybenzoove [Czech]; LXCFILQKKLGQFO-UHFFFAOYSA-N; NCGC00159376-02; NCGC00159376-04; E218; DSSTox_CID_2529; WLN: QR DVO1; DSSTox_RID_76616; DSSTox_GSID_22529; AS-99-76-3; SMR000036660; Methylparaben [USAN]; methyl 4- hydroxybenzoate; Methylparaben [USAN:NF]; Metagin; Tegosept; Lexgard M; Paraben M; 4;carbomethoxyphenol; Methylparaben (NF); Methylparaben (TN); INS number 218; Solparol (Salt/Mix); 4-hydroxymethylbenzoate; methyl 4-hydoxybenzoate; ACMC-20aiv0; methyl 4; hydroxybenzoate; AC1L1OSV; methyl 4-hydroxylbenzoate; methyl 4-hydroxy-benzoate; methyl-4-hydroxy-benzoate; Methylis parahydroxybenzoas; Preserval MS; bmse010009; D0T3NP; EC 202-785-7; methyl (4-hydroxy)benzoate; cid_7456; SCHEMBL4440; MLS001304047; MLS001304187; Methylparaben, United States Pharmacopeia (USP) Reference Standard;InChI=1/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H; Methyl 4-hydroxybenzoate, BioReagent, suitable for insect cell culture;Methyl parahydroxybenzoate, European Pharmacopoeia (EP) Reference Standard; Methyl parabenMethyl p-hydroxybenzoateMethyl parahydroxybenzoateNipagin ME number E218;Methylparaben, Pharmaceutical Secondary Standard; Certified Reference Material;1000398-37-7;156291-94-0;58339-84-7; ARONIS27185; BIDD:ER0241; 4- hydroxybenzoate methyl ester; Methyl 4-Hydroxybenzoate,(S); INS No. 218; GTPL6273; ZINC1712; Methyl parahydroxybenzoate (TN); RARECHEM AL BF 0098; DTXSID4022529; FEMA 2710; TIMTEC-BB SBB040908; 4-Hydroxybenzoic acid methylester; methyl 4-hydroxybenzenecarboxylate; NSC3827; MolPort-000-872-072; OTAVA-BB; 1310956; HMS2883I08; LABOTEST-BB LTBB002210; Methyl Paraben, analytical standard; Methyl parahydroxybenzoate (JP17); 4-hydroxy benzoic acid methyl ester;  CS-D1181; KS-00000KU0; METHYL PARA HYDROXY BENZOATE; NSC-3827; 5026-62-0 (hydrochloride salt); AKOS BBS-00004393; Tox21_111616; Tox21_202318; Tox21_300009; AN-982; ANW-75370; BBL005648; BDBM50209100; CK1194; MFCD00002352; NSC406127; SBB040908; STK802470; Aa(2) (1/2)eth(1/4)xo yen; AKOS000119910; Tox21_111616_1; AS01626; MCULE-5368262482; NSC-406127; RP21588; KS-000048O3; Methyl 4-hydroxybenzoate, 99% 250g; 4-HYDROXYBENZOIC ACID METYL ESTER: ; Methyl 4- hydroxybenzoate, >=99%, FCC; ; Methyl 4-hydroxybenzoate, analytical standard; (2,2-DIMETHYLDIOXALANE)METHYL BUTYRATE; D01400; M-6148; Methyl 4-hydroxybenzoate, USP, 98.0-102.0%; F1908-0119; paragraph signOoC>>u+/-(1/2)(1/4)xEa(1/4)xo yen; Methyl 4-hydroxybenzoate, BioXtra, >=99.0% (titration); Methylparaben, certified reference material, TraceCERT(R); UNII-AZF98361GV component LXCFILQKKLGQFO-UHFFFAOYSA-N; Methyl 4-hydroxybenzoate, ReagentPlus(R), >=99.0%, crystalline; Methyl 4-​Hydroxybenzoate; metilparapen; metil parapen; methyl parapen; methylparapen.

 

 

 

Properties of methylparaben

Molecular Formula: C8H8O3
Molecular Weight: 152.149 g/mol
Melting Point : 125-128° C
Boiling Point : 270-280° C
Density : 1.38 g/cm3 at 20° C

 

 

 

What is Methylparaben?

  Methylparaben belongs to the paraben family of ingredients, which all act as preservatives in skin care products. Typically, this chemical will be formulated into creams and serums with other parabens, like butylparaben and propylparaben, though in some cases it may be used on a standalone basis.The goal of methylparabens and similar chemicals is to prevent the growth of bacteria and fungus. By limiting the growth of microorganisms, this ingredient helps preserve the integrity of skin care formulations for a longer period of time, and also protects the consumer from inadvertently adding contaminated products to their skin.

  Researchers are beginning to study whether the use of methylparabens and other parabens is safe. At this time, there is no conclusive evidence either way. The U.S. Food and Drug Administration (FDA) continues to allow the use of methylparabens in various products.

 

 

 

What Products is Methylparaben Used In?

  Methylparaben is used in many skin care and personal care products, like moisturizers, shampoo, conditioner, eye shadow, sunscreen, and many other items.

 
  In addition to methylparaben, this cream also contains chemicals like sodium hyaluronate, to moisturize the skin; butylene glycol, to condition the skin and at the same time act as a preservative; and succinic acid, to moisturize.

 

Is it safe?

  Methylparaben doesn’t accumulate in the body. In fact, the body flushes the chemical out pretty quickly. Despite this, many consumers are concerned about the safety of methylparaben. These concerns have increased in light of a claimed link to cancer risk. The FDA and other researchers are conducting studies to investigate the safety of methylparaben. So far there hasn’t been any conclusive evidence, though there have been cases of individuals who have had negative reactions. While the FDA is reviewing these studies, they haven’t yet come across anything to show that parabens are unsafe for use in cosmetics, foods, or drugs.The Environmental Working Group (EWG) lists methylparaben as being a low to moderate health hazard. However, the hazard is only in regards to allergic  reactions or product usage exceeding the recommended level. The EWG lists methylparaben’s risk of causing cancer and reproductive toxicity at 0 percent. The Centers for Disease Control (CDC) tested the urine of more than 2,548 participants in a 2005 to 2006 survey. CDC researchers found that most participants had some methylparaben in their urine. They also found that the presence of the chemical didn’t signal a problem on its own. While studies are still being conducted, currently there is no official precaution against using products with methylparaben.

 

 

Possible allergic reactions

  Some people have reported allergies to methylparaben. Contact dermatitis, for example, occurs when the skin has an allergic reaction to something it comes in contact with. Dermatitis usually occurs in the form of a rash that clears up on its own.

  Contact dermatitis rashes can include itching, bumps and blisters, swelling, tenderness, or burning

  If the dermatitis occurs near the eyes, you may experience redness or swelling of the eyelids.

  Other sensitivities can occur when products with methylparaben come in contact with skin that is broken or damaged. There have been some reports of allergy when ingesting parabens, but this hasn’t been researched extensively yet. Life-threatening allergies, such as anaphylaxis, have not been reported.

 

 

Side Effects of Methylparaben

  One of the concerns with methylparaben is its potential link to cancer. For example, some studies have found a correlation between breast tumors and the presence of parabens. However, these chemicals have not been banned, because the link does not seem to be conclusive. Correlation does not necessarily equal causality, and studies have not definitively established parabens as the cause of such tumors.

  The more direct effects of methylparaben (and other parabens) on the human body seem to concern the endocrine system. This system is important for human health, because it regulates our hormones. It’s an important consideration, because hormones play a huge role in how our bodies function.

   For example, high levels of estrogen are believed to be linked to higher occurrences of cancer. High levels of stress hormones (like cortisol) can lead to chronic fatigue and weight gain. It’s really amazing how much the function of our bodies can change from even small shifts in hormone secretions. The potential danger of methylparaben is that it can affect the endocrine system, and the hormones that are being produced. This can in turn affect metabolism and other bodily functions.

  Further, methylparaben is thought to mimic estrogen to a degree, which can further disrupt normal bodily function.

 

 

Methylparaben and the Environment

   Another concern expressed by opponents of using methylparaben in skin care is that this chemical may potentially contaminate the environment. For example, discarded cream tubes and jars will still have small amounts of product in them, and particles of this chemical may also make it into oceans and rivers as it is washed off the skin while taking a shower. However, at the moment it is not believed that methylparaben is a serious threat to the environment, as this chemical can be broken down by bacteria commonly found in soil.

 

 

 

 

Metilparaben Özellikleri

Moleküler Formül: C8H8O3
Molekül Arl: 152.149 g / mol
Erime Noktas: 125-128 ° C
Kaynama Noktas: 270-280 ° C
Younluk: 20 ° C’de 1.38 g / cm3

 

 

   Methylparaben, hepsi cilt bakm ürünlerinde koruyucu madde olarak ilev gören paraben ailesine aittir. Tipik olarak, bu kimyasal, bütilparaben ve propilparaben gibi dier parabenler ile kremler ve serumlar halinde formüle edilecektir, ancak baz durumlarda bamsz bir ekilde kullanlabilir. Metilparabenler ve benzer kimyasallarn amac bakterilerin ve mantarn büyümesini engellemektir. Mikroorganizmalarn büyümesini snrlandrarak, bu bileen cilt bakm formülasyonlarnn bütünlüünü daha uzun bir süre korur ve ayn zamanda tüketiciyi yanllkla kirlenmi ürünleri cildine ekleyerek korur.

Aratrmaclar, metilparabens ve dier parabenler kullanmnn güvenli olup olmadn incelemeye balyor. u anda, hiçbir ekilde kesin bir kant yoktur.ABD Gda ve laç daresi (FDA), çeitli ürünlerde metilparabenlerin kullanlmasna izin vermeye devam etmektedir.

 

 

Hangi Ürünlerde Methylparaben kullanlr?

  Methylparaben birçok cilt bakm ve nemlendirici, ampuan, saç kremi, göz far, güne kremi ve dier birçok ürün gibi kiisel bakm ürünlerinde kullanlr.

  Metilparaben ek olarak, bu krem ​​de cildi nemlendirmek için sodyum hiyalüronat gibi kimyasallar içerir; bütilen glikol, cildi korumak ve ayn zamanda bir koruyucu olarak davranmak; ve süksinik asit, nemlendirir.

 

 

 

Güvenli mi?

  Methylparaben vücutta birikmez. Aslnda, vücut kimyasallar çok çabuk temizler. Buna ramen, birçok tüketici endie duyuyor metilparaben güvenlii. Bu endieler, kanser riskine yönelik iddia edilen bir balant nda artmtr. FDA ve dier aratrmaclar, metilparaben güvenliini aratrmak için çalmalar yürütüyorlar. imdiye kadar kesin bir kant yoktu. Olumsuz tepkiler alm bireyler vakas olmutur. FDA bu çalmalar incelerken, henüz gösterilecek hiçbir eye rastlamadlar. Bu parabenler kozmetik, gda veya ilaçlarda kullanm için güvensizdir. Çevresel Çalma Grubu (EWG), metilparaben’i düük ila orta dereceli salk tehlikesi olarak listelemektedir. Ancak, tehlike sadece alerjik açdan önemlidir.Tepkiler veya önerilen kullanm seviyesini aan ürün kullanm. EWG, metilparaben’in kansere ve üreme toksisitesine neden olma riskini yüzde 0 olarak listelemektedir.Hastalk Kontrol Merkezleri (CDC) 2005 ila 2006 anketinde 2,548’den fazla katlmcnn idrarn test etti. CDC aratrmaclar çou katlmcy buldudrarlarnda baz metilparaben vard. Ayrca, kimyasaln varlnn kendi bana bir sorun olmadn da fark ettiler.Çalmalar halen devam ederken, u anda metilparaben ile ürün kullanmnakar resmi bir önlem bulunmamaktadr.

 

 

 

 Olas alerjik reaksiyonlar

  Baz insanlar metilparaben alerjisi bildirmitir. Kontakt dermatit, örnein, cildin içeri girdii bir eye alerjik reaksiyon gösterdiinde ortaya çkar. iletiime geç. Dermatit genellikle kendi kendine temizlenen bir döküntü eklinde ortaya çkar. Kontakt dermatit döküntüleri kant, çarpma ve kabarcklar, ilik, hassasiyet veya yanma olabilir. Dermatit gözlerin yaknnda meydana gelirse, göz kapaklarnn kzarkl veya imesi ile karlaabilirsiniz. Metilparabenli ürünler krlm veya hasarl deri ile temas ettiinde dier hassasiyetler ortaya çkabilir. Baz alerji raporlar olmutur.Parabenler yutulurken, ancak bu henüz kapsaml bir ekilde aratrlmamtr. Anafilaksi gibi hayat tehdit eden alerjiler bildirilmemitir.

 

 

 

Methylparaben’in Yan Etkileri

  Metilparaben ile ilgili endielerden biri de kansere kar potansiyel balantsdr. Örnein, baz çalmalar meme tümörleri ve parabenler varl arasnda bir korelasyon bulmutur. Ancak, bu kimyasallar yasaklanmamtr, çünkü balant kesin deildir. Korelasyon, mutlaka eit nedensellik deildir ve çalmalar, bu tür tümörlerin nedeni olarak parabenleri kesin olarak kurmamtr.

  Metil parabenlerin (ve dier parabenler) insan vücudu üzerindeki daha dorudan etkileri, endokrin sistemi ilgilendirmektedir. Bu sistem insan sal için önemlidir, çünkü hormonlarmz düzenler. Bu önemli bir husustur, çünkü hormonlar vücudumuzun ilevinde büyük rol oynarlar.

  Örnein, yüksek östrojen seviyelerinin, daha yüksek kanser oluumlarna bal olduuna inanlmaktadr. Yüksek stres hormonlar (kortizol gibi), kronik yorgunlua ve kilo almna yol açabilir. Vücudumuzun ilevinin hormon salglarndaki küçük deiikliklerden bile ne kadar deiebilecei gerçekten artc.

  Metilparabenin potansiyel tehlikesi, endokrin sistemini ve üretilen hormonlar etkileyebilmesidir. Bu da metabolizmay ve dier vücut fonksiyonlarn

etkileyebilir.

  Ayrca, metilparabenin östrojeni normal vücut fonksiyonunu daha da bozabilecek bir dereceye benzedii düünülmektedir.

 

 

Metilparaben ve Çevre

  Muhaliflerin cilt bakmnda metilparaben kullanmasyla ilgili olarak dile getirilen bir baka sorun da, bu kimyasal maddenin çevreyi kirletebileceidir. Örnein, atlm krem tüpler ve kavanozlar, içinde hala az miktarda ürün bulundururlar ve bu kimyasaln parçacklar da du alrken cildin ykanmas nedeniyle okyanus ve nehirlere dönüebilir. Ancak, u anda, metilparaben’in çevreye yönelik ciddi bir tehdit olduuna inanlmamaktadr, çünkü bu kimyasal topraa yaygn olarak bulunan bakteriler tarafndan parçalanabilir.