NIACINAMIDE (NYASNAMD)

CAS NO: 98-92-0

NIACINAMIDE HYDROCHLORIDE; Nicotinamide hydrochloride; UNII-4D16EOF1QW; 4D16EOF1QW; 25334-23-0; NIACINAMIDE HYDROCHLORIDE; Nicotinamide hydrochloride; UNII-4D16EOF1QW; 4D16EOF1QW; 25334-23-0; Nicotinamide HCl; 3-Pyridinecarboxamide, monohydriodide; nicotinamide hydrochloride(1:1); 3-Pyridinecarboxamide, hydriodide (1:1); EINECS 246-862-3; SCHEMBL1220080; CTK8D8479; DTXSID00179982; OBLVPWTUALCMGD-UHFFFAOYSA-N; ACM25334230; Q27259427; Niacinamide 4-hydroxybenzoate; UNII-3JS66VCM9S; 3JS66VCM9S; Niacinamide p-hydroxybenzoate; SCHEMBL17840949; (4-hydroxybenzoic acid).(nicotinamide); Q27257324; UNII-O6UVL49A6X component ZTOJOQVYMATCDU-UHFFFAOYSA-N; Benzoic acid, 4-hydroxy-, compd. with 3-pyridinecarboxamide (1:1); 1236289-99-8; nicotinamide; niacinamide; 98-92-0; 3-Pyridinecarboxamide; pyridine-3-carboxamide; vitamin PP; Nikotinamid; Nicotinic amide; Delonin amide; Vitamin B; Nicotilamide; Nicotililamido; Niacevit; Nicamina; Nicamindon; Nicofort; Nicotamide; Nicovitina; Nicovitol; Nicozymin; Niocinamide; Niozymin; Niamide; NIACINAMIDE; NACNAMDE; niacinamide; niyacinamide; NCOTNAMDE; NICOTINAMIDE; nicotinamide; Niacinamide; NIACINAMIDE; NACNAMDE; niacinamide; niyacinamide; NCOTNAMDE; NICOTINAMIDE; nicotinamide; nicotinamide; nicotinamide; NCOTN AMDE; niyasinamide; NYASNAMDE; NACIN AMIDE; NYASN AMD; NYASNE; NASNAMDE; NIASINAMIDE; NIACINAMIDE; 3-pyridinecarboxamide; niacinamide; amide d’acide nicotinique; vitamine PP; amide nicotinique; vitamine B3;nicotinamid; nicotinamide; NCOTN AMDE; niyasinamid; NYASNAMDE; NACIN AMIDE; NYASN AMD; NYASNE; NASNAMDE; NIASINAMIDE; NIACINAMIDE; 3-pyridinecarboxamide; niacinamide; nicotinic acid amide; vitamin PP; nicotinic amide; vitamin B3; NIACINAMIDE; NACNAMDE; niacinamide; niyacinamide; NCOTNAMDE; NICOTINAMIDE; nicotinamide; nicotinamid; nicotinamide; NCOTN AMDE; niyasinamid; NYASNAMDE; NACIN AMIDE; NYASN AMD; NYASNE; NASNAMDE; NIASINAMIDE; NIACINAMIDE; 3-pyridinecarboxamide; niacinamide; nicotinic acid amide; vitamin PP; nicotinic amide; vitamin B3; nicotinamide; niacinamide; 98-92-0; 3-Pyridinecarboxamide; pyridine-3-carboxamide; Nicotinic acid amide; vitamin PP; Papulex; Aminicotin; Amixicotyn; Nicobion; Nicotylamide; Nikotinamid; Savacotyl; Benicot; Dipegyl; Endobion; Hansamid; Pelmine; Nicotinic amide; Delonin amide; Pelonin amide; Vi-Nicotyl; Austrovit PP; Inovitan PP Vitamin B; Nicosylamide; Nicotilamide; Nicotililamido; Amnicotin; Niacevit; Nicamina; Nicamindon; Nicofort; Nicomidol; Nicotamide; Nicovitina; Nicovitol; Nicozymin; Niocinamide; Niozymin; Niamide; Nicasir; Nicogen; Nicota; Nicotol; Nicovit; Niko-tamin; 3-Carbamoylpyridine; Nicotine acid amide; Nandervit-N; Pyridine-3-carboxylic acid amide; Niavit PP; NIACINAMIDE; NACNAMDE; niacinamide; niyacinamide; NCOTNAMDE; NICOTINAMIDE; nicotinamide; NIACINAMIDE; NACNAMDE; niacinamide; niyacinamide; NCOTNAMDE; NICOTINAMIDE; nicotinamide; nicotinamide; nicotinamide; NCOTN AMDE; niyasinamide; NYASNAMDE; NACIN AMIDE; NYASN AMD; NYASNE; NASNAMDE; NIASINAMIDE; NIACINAMIDE; 3-pyridinecarboxamide; niacinamide; amide d’acide nicotinique; vitamine PP; amide nicotinique; vitamine B3;nicotinamid; nicotinamide; NCOTN AMDE; niyasinamid; NYASNAMDE; NACIN AMIDE; NYASN AMD; NYASNE; NASNAMDE; NIASINAMIDE; NIACINAMIDE; 3-pyridinecarboxamide; niacinamide; nicotinic acid amide; vitamin PP; nicotinic amide; vitamin B3; NIACINAMIDE; NACNAMDE; niacinamide; niyacinamide; NCOTNAMDE; NICOTINAMIDE; nicotinamide; nicotinamid; nicotinamide; NCOTN AMDE; niyasinamid; NYASNAMDE; NACIN AMIDE; NYASN AMD; NYASNE; NASNAMDE; NIASINAMIDE; NIACINAMIDE; 3-pyridinecarboxamide; niacinamide; nicotinic acid amide; vitamin PP; nicotinic amide; vitamin B3; nicotinamide; niacinamide; 98-92-0; 3-Pyridinecarboxamide; pyridine-3-carboxamide; Nicotinic acid amide; vitamin PP; Papulex; Aminicotin; Amixicotyn; Nicobion; Nicotylamide; Nikotinamid; Savacotyl; Benicot; Dipegyl; Endobion; Hansamid; Pelmine; Nicotinic amide; Delonin amide; Pelonin amide; Vi-Nicotyl; Austrovit PP; Inovitan PP Vitamin B; Nicosylamide; Nicotilamide; Nicotililamido; Amnicotin; Niacevit; Nicamina; Nicamindon; Nicofort; Nicomidol; Nicotamide; Nicovitina; Nicovitol; Nicozymin; Niocinamide; Niozymin; Niamide; Nicasir; Nicogen; Nicota; Nicotol; Nicovit; Niko-tamin; 3-Carbamoylpyridine; Nicotine acid amide; Nandervit-N; Pyridine-3-carboxylic acid amide; Niavit PP; Nikotinamid (Niasinamid); Nicotine acid amide; Nandervit-N; Pyridine-3-carboxylic acid amide; Niavit PP; Nicosan 2; Nicotine amide; beta-Pyridinecarboxamide; Nikotinsa ureamid; Nicotylamidum; Nicotinsaureamid; Pyridine, 3-carbamoyl-; Nicotinamidum; Nicotinamida; Vitamin B (VAN); Amid kyseliny nikotinove; Witamina PP; PP-Faktor; Nicotinamide (Vitamin B3); NSC 13128; Niacinamide;Nicotinic acid amide;Vitamin B3; Vitamin PP; Nicotinamide, British Pharmacopoeia (BP) Reference Standard; A186B02E-6C70-4E54-9739-79398D439AAA; Nicotinamide, European Pharmacopoeia (EP) Reference Standard; Niacinamide, United States Pharmacopeia (USP) Reference Standard; InChI=1/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9; Niacinamide, Pharmaceutical Secondary Standard; Certified Reference Material; amid; amide; amit; amite; niacinamide; niacinamid; niacinamit; niacinamite; niacidamid; niacidamide; niacidamit; niacidamite; niacinamide; niacinamid; niacinamit; niacinamite; niacidamid; niacidamide; niacidamit; niacidamite; niacin amide; niacin amid; niacin amit; niacin amite; niacid amid; niacid amide; niacid amit; niacid amite; ni acinamide; ni acinamid; ni acinamit; ni acinamite; ni acidamid; ni acidamide; ni acidamit; ni acidamite; ni acin amide; ni acin amid; ni acin amit; ni acin amite; ni acid amid; ni acid amide; ni acid amit; ni acid amite; acidamid: acid amid; acid amide; acidamide; acidamit; acid amit; acidamite; acid amite; niacitamide; niacitamit; niacit amide; niacit amit; niacitamite; niacitamit; niacite amide; niacitoamide; niacitamit; niacito amide; niacito amit; niacitomite; niacitomit; niacite omide; n-acitamide; n-acitamit; n-acit amide; n-acit amit; n-acitamite; n-acitamit; n-acite amide; AMID; AMIDE; AMIT; AMITE; NIACINAMIDE; NIACINAMID; NIACINAMIT; NIACINAMITE; NIACIDAMID; NIACIDAMIDE; NIACIDAMIT; NIACIDAMITE; NIACINAMIDE; NIACINAMID; NIACINAMIT; NIACINAMITE; NIACIDAMID; NIACIDAMIDE; NIACIDAMIT; NIACIDAMITE; NIACIN AMIDE; NIACIN AMID; NIACIN AMIT; NIACIN AMITE; NIACID AMID; NIACID AMIDE; NIACID AMIT; NIACID AMITE; NI ACINAMIDE; NI ACINAMID; NI ACINAMIT; NI ACINAMITE; NI ACIDAMID; NI ACIDAMIDE; NI ACIDAMIT; NI ACIDAMITE; NI ACIN AMIDE; NI ACIN AMID; NI ACIN AMIT; NI ACIN AMITE; NI ACID AMID; NI ACID AMIDE; NI ACID AMIT; NI ACID AMITE; ACIDAMID: ACID AMID; ACID AMIDE; ACIDAMIDE; ACIDAMIT; ACID AMIT; ACIDAMITE; ACID AMITE; NIACITAMIDE; NIACITAMIT; NIACIT AMIDE; NIACIT AMIT; NIACITAMITE; NIACITAMIT; NIACITE AMIDE; NIACITOAMIDE; NIACITAMIT; NIACITO AMIDE; NIACITO AMIT; NIACITOMITE; NIACITOMIT; NIACITE OMIDE; N-ACITAMIDE; N-ACITAMIT; N-ACIT AMIDE; N-ACIT AMIT; N-ACITAMITE; N-ACITAMIT; N-ACITE AMIDE; niyacinamide; niacinamid; niacinamit; niacinamite; niacidamid; niacidamide; niacidamit; niacidamite; niacinamide; niacinamid; niacinamit; niacinamite; niacidamid; niacidamide; niacidamit; niacidamite; niacin amide; niacin amid; niacin amit; niyacin amite; niyacid amid; niyacid amide; niyacid amit; niyacid amite; niy acinamide; niy acinamid; niy acinamit; niy acinamite; ni acidamid; ni acidamide; ni acidamit; ni acidamite; ni acin amide; ni acin amid; niy acin amit; niy acin amite; niy acid amid; niy acid amide; niy acid amit; niy acid amite; aycidamid: acid amid; acid amide; acidamide; acidamit; acid amit; acidamite; acid amite; niyacitamide; niyacitamit; niyacit amide; niyacit amit; niyacitamite; niyacitamit; niyacite amide; niyacitoamide; niyacitamit; niacito amide; niacito amit; niacitomite; niacitomit; niyacite omide; n-aycitamide; n-aycitamit; n-aycit amide; n-aycit amit; n-aycitamite; n-aycitamit; n-acyite amide; niasinamide; niasinamid; niasinamit; niasinamite; niasidamid; niasidamide; niasidamit; niasidamite; niasinamide; niasinamid; niasinamit; niasinamite; niasidamid; niasidamide; niacidamit; niasidamite; niacin amide; niacin amid; niacin amit; niasin amite; niasid amid; niasid amide; niasid amit; niasid amite; ni asinamide; ni acinamid; ni acinamit; ni acinamite; ni acidamid; ni asidamide; ni asidamit; ni asidamite; ni asin amide; ni asin amid; ni acin amit; ni acin amite; ni asid amid; ni asid amide; ni asid amit; ni asid amite; asidamid: asid amid; asid amide; asidamide; acidamit; asid amit; asidamite; acid amite; niasitamide; niasitamit; niasit amide; niasit amit; niasitamite; niasitamit; niasite amide; niasitoamide; niasitamit; niasito amide; niasito amit; niacitomite; niacitomit; niasite omide; n-asitamide; n-asitamit; n-asit amide; n-asit amit; n-asitamite; n-asitamit; n-asite amide; NIYACINAMIDE; NIACINAMID; NIACINAMIT; NIACINAMITE; NIACIDAMID; NIACIDAMIDE; NIACIDAMIT; NIACIDAMITE; NIACINAMIDE; NIACINAMID; NIACINAMIT; NIACINAMITE; NIACIDAMID; NIACIDAMIDE; NIACIDAMIT; NIACIDAMITE; NIACIN AMIDE; NIACIN AMID; NIACIN AMIT; NIYACIN AMITE; NIYACID AMID; NIYACID AMIDE; NIYACID AMIT; NIYACID AMITE; NIY ACINAMIDE; NIY ACINAMID; NIY ACINAMIT; NIY ACINAMITE; NI ACIDAMID; NI ACIDAMIDE; NI ACIDAMIT; NI ACIDAMITE; NI ACIN AMIDE; NI ACIN AMID; NIY ACIN AMIT; NIY ACIN AMITE; NIY ACID AMID; NIY ACID AMIDE; NIY ACID AMIT; NIY ACID AMITE; AYCIDAMID: ACID AMID; ACID AMIDE; ACIDAMIDE; ACIDAMIT; ACID AMIT; ACIDAMITE; ACID AMITE; NIYACITAMIDE; NIYACITAMIT; NIYACIT AMIDE; NIYACIT AMIT; NIYACITAMITE; NIYACITAMIT; NIYACITE AMIDE; NIYACITOAMIDE; NIYACITAMIT; NIACITO AMIDE; NIACITO AMIT; NIACITOMITE; NIACITOMIT; NIYACITE OMIDE; N-AYCITAMIDE; N-AYCITAMIT; N-AYCIT AMIDE; N-AYCIT AMIT; N-AYCITAMITE; N-AYCITAMIT; N-ACYITE AMIDE; NIASINAMIDE; NIASINAMID; NIASINAMIT; NIASINAMITE; NIASIDAMID; NIASIDAMIDE; NIASIDAMIT; NIASIDAMITE; NIASINAMIDE; NIASINAMID; NIASINAMIT; NIASINAMITE; NIASIDAMID; NIASIDAMIDE; NIACIDAMIT; NIASIDAMITE; NIACIN AMIDE; NIACIN AMID; NIACIN AMIT; NIASIN AMITE; NIASID AMID; NIASID AMIDE; NIASID AMIT; NIASID AMITE; NI ASINAMIDE; NI ACINAMID; NI ACINAMIT; NI ACINAMITE; NI ACIDAMID; NI ASIDAMIDE; NI ASIDAMIT; NI ASIDAMITE; NI ASIN AMIDE; NI ASIN AMID; NI ACIN AMIT; NI ACIN AMITE; NI ASID AMID; NI ASID AMIDE; NI ASID AMIT; NI ASID AMITE; ASIDAMID: ASID AMID; ASID AMIDE; ASIDAMIDE; ACIDAMIT; ASID AMIT; ASIDAMITE; ACID AMITE; NIASITAMIDE; NIASITAMIT; NIASIT AMIDE; NIASIT AMIT; NIASITAMITE; NIASITAMIT; NIASITE AMIDE; NIASITOAMIDE; NIASITAMIT; NIASITO AMIDE; NIASITO AMIT; NIACITOMITE; NIACITOMIT; NIASITE OMIDE; N-ASITAMIDE; N-ASITAMIT; N-ASIT AMIDE; N-ASIT AMIT; N-ASITAMITE; N-ASITAMIT; N-ASITE AMIDE

acidoamit; acido amit; acidoamite; acido amite; acidoamin; acido amin; acidoamine; acido amine; amin;
neacidamide; neacid amide; neacitamide; neacit amide;

nacinamide; nacinamid; nacinamit; nacinamite; nacidamid; nacidamide; nacidamit; nacidamite; nacin amide; nacin amid; nacin amit; nacin amite; nacid amid; nacid amide; nacid amit; nacid amite;
n-acinamide; n-acinamid; n-acinamit; n-acinamite; n-acidamid; n-
acidamide; nacidamit; nacidamite;

Nicotinamide, BioReagent, suitable for cell culture, suitable for insect cell culture;
Nicotinamide (Vitamin B3) solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material;
Niacinamide (vitamin B3) reduces the appearance of skin blemishes and congestion. A high 10 percent concentration
of this vitamin is supported in the formula by zinc PCA to balance visible aspects of sebum activity.

The Ordinary’s Niacinamide 10% + Zinc 1% is a high-strength vitamin and mineral blemish formula with 10% pure niacinamide and 1% zinc PCA.
Niacinamide (Vitamin B3) – indicated to reduce the appearance of skin blemishes and congestion
Zinc Salt of Pyrrolidone Carboxylic Acid – balances visible aspects of sebum activity.

Niacinamide, also called nicotinamide, is a form of vitamin B-3, an essential nutrient. A B-3 deficiency can lead to disorders of the skin,
kidneys, and brain. Taking niacinamide can help prevent B-3 deficiency. And there’s much more to this nutrient, especially when it comes
to general skin health. Although more research is needed, topical niacinamide may help treat certain skin conditions, including acne and eczema.

Despite the similarities in names, niacinamide isn’t the same thing as niacin. They’re two different types of vitamin B-3.
However, your body can make niacinamide from niacin supplements you’ve taken. This happens when there’s an excessive amount of niacin in the body.
Tryptophan in the body can also be converted into niacinamide.

Many topical niacinamide products come in the form of serums. Think of serums as extra treatments that address individual skin concerns outside
of regular cleansing, toning, and moisturizing. Your niacinamide serum should be applied after toning but before moisturizing.
Some cleansers and creams also contain niacinamide. This ingredient is also found in some face masks, which are rinsed off after each use.

Niacinamide concentration can vary across products, though most formulations are 5 percent or less.
If you have sensitive skin, you may want to start with a lower concentration. Formulas with 2 percent niacinamide may help ease symptoms
of eczema and similar conditions. Niacinamide may be listed as “niacin” and “nicotinamide” on product labels.

Niacinamide may be used alongside other active ingredients for optimal results. For example, some reports suggest that supplemental niacinamide
may work well alongside copper, folic acid, and zinc to treat acne.
You may be able to get more out of your niacinamide serum by using it alongside hyaluronic acid. Hyaluronic acid is said to increase product absorption.

When used topically every day, niacinamide may have a positive impact on your overall skin health. The ingredient can help reduce inflammation
and hyperpigmentation, smooth your overall skin texture, and brighten your skin. It can take several weeks to see noticeable improvement, so it’s important
to be patient and to stick with your routine. You should not take niacinamide supplements unless your doctor or other healthcare provider prescribes
them to treat a B-3 deficiency or other underlying condition.

A skincare ingredient I am always recommending to my clients is Niacinamide. Something of an unsung hero, this multi-tasking ingredient, also known as Vitamin B3,
boasts a long list of benefits. It can help improve the appearance of enlarged pores, fight signs of ageing, lighten dark spots and even control acne.
Loved by dermatologists, it is well tolerated and one of the best all-rounders, suitable for everyone ingredients and thankfully it can be found in a variety of
skincare products, including serums and creams. Whether your skin is dry, dehydrated, oily or combination, niacinamide has a place in your skincare routine.
Niacinamide can also help brighten a dull complexion and gently even out discoloration (like sun spots or leftover marks from spots) and uneven texture
(like large pores and dullness).

Niacinamide is one of the most versatile skincare ingredients and is super easy to incorporate into your routine. Suitable for all skin types and all ages
(from teens to mature skin) it can be used both morning and evening but remember consistency is key if you want to see results. Those who use it report
an increase in plump, hydrated skin as well as a reduction in sensitivity, acne and visible pores. It also plays very well alongside ingredients like
retinol and alpha hydroxy acids (AHA’s), so you don’t have to worry about it reacting with something else you’re using. If you haven’t tried it before,
here are some products to start you on your niacinamide journey! The Ordinary Niacinamide 10% + Zinc 1% Serum: One of their best-selling skincare products,
this serum combines a high concentration of Niacinamide with Zinc to balance skin’s sebum (oil) production. Expect to see an improvement in the appearance of
enlarged and visible pores. Olay Regenerist Three Point Super Serum: This serum is a fast absorbing, non-greasy formula made up of niacinamide
and a highly concentrated peptide complex, especially designed to give you dramatically firmer looking skin.

The latest addition to the Pestle & Mortar family, this facial toner powered by glycolic acid is blended with a potent mix of natural anti-ageing and
skin-brightening ingredients, niacinamide being one of them. Expect brighter, healthier fresher skin.A potent vitamin serum fortified with niacinamide
and copper tripeptide to take on daily environmental elements and to help prevent the appearance of premature ageing.A powerful daytime serum that contains
an encapsulated blend of vitamin C and niacinamide to help diminish the appearance of dark spots. redness and discoloration.

Vitamin B3 5% Niacinamide Serum by Eva Naturals, the time for beautiful skin is now! Niacinamide, also known as Vitamin B3, offers your complexion an incredible
range of benefits. To maximize results, we paired it with other powerful ingredients your skin will love. Along with Aloe, it improves elasticity by nourishing your
skin with fatty acids, enhancing barrier function and restoring youthful vibrancy!
Next, Niacinamide teams up with Avocado to banish breakouts and reduce inflammation. You’ll even see a reduction in redness and discoloration for a smooth,
even complexion. Finally, Hyaluronic Acid works to protect your skin from free radical damage and UV rays while plumping away wrinkles for a fresh,
hydrated appearance!

Tropical niacinamide (vitamin B3) has been observed to be well tolerated by skin and to provide a broad array of improvements in the appearance of aging
facial skin (eg, reduction in the appearance of hyperpigmentated spots and red blotchiness). Clinically determine the effect of topical niacinamide on additional
skin appearance and property end points (wrinkles, yellowing, and elasticity). Analyses of the data revealed a variety of significant skin appearance
improvement effects for topical niacinamide: reductions in fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness (yellowing).
In addition, elasticity (as measured via cutometry) was improved.

There are two forms of vitamin B3. One form is niacin, the other is niacinamide. Niacinamide is found in many foods including yeast, meat, fish, milk, eggs,
green vegetables, beans, and cereal grains. Niacinamide is also found in many vitamin B complex supplements with other B vitamins. Niacinamide can also be
formed in the body from dietary niacin. Do not confuse niacinamide with niacin, NADH, nicotinamide riboside, inositol nicotinate, or tryptophan. See the
separate listings for these topics. Niacinamide is taken by mouth for preventing vitamin B3 deficiency and related conditions such as pellagra.
It is also taken by mouth for acne, diabetes, oral cancer, osteoarthritis, and many other conditions. However, there is no good scientific evidence to
support these uses. Niacinamide is also applied to the skin for acne, eczema, and other skin conditions. There is also no good evidence to support these uses.
Niacinamide can be made from niacin in the body. Niacin is converted to niacinamide when it is taken in amounts greater than what is needed by the body.
Niacinamide is easily dissolved in water and is well-absorbed when taken by mouth.Niacinamide is required for the proper function of fats and sugars in the
body and to maintain healthy cells. Unlike niacin, niacinamide has no beneficial effects on fats and should not be used for treating high cholesterol
or high fat levels in the blood.

Early research shows that taking tablets containing niacinamide and other ingredients for 8 weeks improves skin appearance in people with acne. Other research
shows that applying a cream containing niacinamide improves the appearance of skin in people with acne. Some research shows that taking niacinamide might help
prevent the loss of insulin production in children and adults at risk for type 1 diabetes. It might also prevent the loss of insulin production and reduce
the dose of insulin needed by children recently diagnosed with type 1 diabetes. However, niacinamide does not seem to prevent the development of type 1 diabetes
in at-risk children. In people with type 2 diabetes, niacinamide seems to help protect insulin production and improve blood sugar control.
High levels of phosphate in the blood (hyperphosphatemia). High blood levels of phosphate can be caused by reduced kidney function. In people with kidney
failure who are on hemodialysis and have high levels of blood phosphate, taking niacinamide seems to help decrease phosphate levels when taken with or without
phosphate binders. Research shows that taking niacinamide while receiving radiotherapy and a type of treatment called carbogen might help control tumor growth and
increase survival in some people with cancer of the larynx. Taking niacinamide while receiving radiotherapy and carbogen seems to benefit people with cancer
of the larynx who are also anemic. It also seems to help people who have tumors that are deprived of oxygen. Taking niacinamide seems to help prevent
new skin cancer or precancerous spots (actinic keratosis) from forming in people with a history of skin cancer or actinic keratosis. Taking niacinamide seems
to improve joint flexibility and reduce pain and swelling in people with osteoarthritis. Also, some people with osteoarthritis who take niacinamide might
need to take fewer pain medications. Early research shows that treating people with surgically removed brain tumors with niacinamide, radiotherapy, and carbogen
does not improve survival compared to radiotherapy or radiotherapy and carbogen. Treating people with bladder cancer with niacinamide, radiotherapy,
and carbogen does not appear to decrease tumor growth or improve survival compared to radiotherapy or radiotherapy and carbogen.

Insufficient Evidence for An eye disease that leads to vision loss in older adults (age-related macular degeneration or AMD). Early research suggests that
taking niacinamide, vitamin E, and lutein for a year improves how well the retina works in people with age-related vision loss due to retina damage.

Early research shows that taking niacinamide, vitamin E, and lutein for almost a year improves how well the retina works in people with
age-related vision loss due to retina damage. Early research shows that applying cream containing 2% niacinamide decreases water loss and improves hydration,
and reduces redness and scaling, in people with eczema. There is conflicting evidence regarding the usefulness of niacinamide in combination with other
vitamins for the treatment of ADHD. Skin redness caused by injury or irritation (erythema). Early research shows that applying a cream containing niacinamide
reduces skin redness, dryness, and itching caused by the acne medication isotretinoin. Long-term kidney disease (chronic kidney disease or CKD).
Early research shows that taking niacinamide does not help reduce itchiness in people with kidney disease. Dark skin patches on the face (melasma).

Early research shows that applying moisturizer containing 5% niacinamide or 2% niacinamide with 2% tranexamic acid for 4-8 weeks helps lighten skin in people
with darkened patches of skin. Cancer that starts in white blood cells (non-Hodgkin lymphoma). Early research shows that taking niacinamide as part of
treatment with a drug called vorinostat might help people with lymphoma go in to remission. A skin condition that causes redness on the face (rosacea).
Early research shows that taking tablets containing niacinamide and other ingredients for 8 weeks improves skin appearance in people with rosacea.
Rough, scaly skin on the scalp and face (seborrheic dermatitis). Early research shows that applying a cream containing 4% niacinamide can reduce
redness and scaling of the skin in people with seborrheic dermatitis.

Niasinamid veya B3 vitamini – ar sebum ve kzarkl azaltmaya yardmc olduu hassas ve problemli
ciltler için mükemmeldir. Serum ayrca cildi yattrmaya ve nemlendirmeye yardmc olan %1 hyaluronik
asit kusursuz bir cilde sahip olmanz salar.

B3 Vitamini olarak da bilinen Niasinamid veya dier ismi ile Nikotinik Asitin hücreler aras iletiimi salayan bir ajandr ve cilt için birden fazla yarar vardr.
Niasinamid’in cilt elastikiyetini gelitirdii baz çalmalar ile kantlanmtr.
Ayrca cilt bariyeri fonksifonunu stabilize ettii ve gelitirdii de bilinmektedir. En önemli özellii ve en yaygn kullanm amac ise
cilt tonu eitsizliklerinde ciltteki ton farkllklar Alfa Hidroksi Asitler ile giderildii zaman ton farkllklarnn tekrardan olumamas
için melanin sentezini basklayabilmesidir. Bir de baz çalmalarda Niasinamid’in yalanma ve sivilcelenmeye yatkn ciltlerde anti enflamatuar
etkisinden dolay akneye ve rozasea ya eilimli ciltlerde bu endieleri giderici etkilerinin gözlendii vurgulanmtr.

B3 vitamininin dier addr. Kozmetikte Niasinamid yazlr. Leke gidericidir, leke kremlerinin iceriginde ilk 5te ismi yaziyorsa leke icin etkilidir.
sivilcelere iyi gelen bir vitamindir. yal ciltleri kurutur. ayrca krkla falan da iyi gelir.
Niasinamid cilt rahatszlklarnda iyi geldii, özellikle cilt lekelerini giderdii bilinmektedir, sivilcelere iyi geldii bilinir ve ciltte sebum dengesini
salamakta kullanlr. Niasinamid ayrca cilt krklklarna kar etkilidir. Ciltte nemlendirme ve cildi düzenlemekte kullanlmaktadr.
sivilcelere oldukça faydal bir vitamin olan Niasinamid yani niacinin bir baka türevi piyasada nicotinamid olarak da bilinir. Bu vitamini içeren ürünler
üzerinde yaplan çalmalar sonucu %5 orannda niacin içeren malzemeler sivilceler üzerinde oldukça etkili olmular.

Vitamin B3’ün niacin ve niacinamide olmak üzere iki formu var. Suda çözünen bir B vitamini formu olan niacinamide, nikotinik asit olarak da biliniyor.
Hem oral hem de harici kullanmnn cilt üzerindeki olumlu etkileri bilimsel çalmalarla da kantlanm bu özel vitaminin kullanm alan oldukça geni.
Öne çkan etkileri; erken yalanma belirtilerini önlemek, cilt rengini düzenlemek ve akneli cildi yattrmak eklinde. Nemlendiricilerden cilt beyazlatc
serumlara, toniklerden göz kremlerine kadar bugün pek çok cilt bakm ürünlerinde niacinamide var.

Niacinamide içeren cilt bakm ürünlerinin cilt beyazlatc / ton dengeleyici özellii en önemli faydalar arasnda yer alyor. Hiperpigmentasyon sorunlarnda en
çok bavurulan içeriklerden olan vitamin, yaps itibariyle özellikle akne iltihaplanmalarnda rol oynayan hücresel mekanizmalar duraksatarak leke oluumunun
önüne geçiyor. 2004 ylnda International Journal of Cosmetic Science dergisinde yaynlanan bilimsel bir makalede paylalan veriler oldukça etkileyici.
Buna göre, 35 ile 60 ya arasnda deien 50 kadn, yüzlerinin yarsna tam 12 hafta boyunca içerisinde %5 orannda niacinamide bulunan nemlendirici bir
krem uyguluyor. Aratrmann sonuçlar ilham verici. Çalmada, 12 hafta sonunda yüzün krem uygulanan tarafndaki leke ve krklklarda dier tarafa oranla
ciddi bir düzelme olduu gözlenmi.
Bu bakm kreminin en önemli özellii salyangoz özü, 20 farkl bitki ekstresi ve niacinamide olmak üzere üç süper gücü bir arada bulundurmas.

Beyazlatc etkisiyle de bilinen niacinamide cildin temiz ve yumuak bir dokuya sahip olmasna da yardmc oluyor.Niacinamide ciltteki serbest ya asidi ve
seramid orann artryor. Cildin nemi tutmas, kzarklk tarz lekelerden korunmas ve salkl bir bariyer oluturmasna büyük katks var.
Niacinamide içeren nemlendirici kremlerden kullanarak bu etkilerin hepsi bir arada kullanlabilir.Niacinamide mucizesi sivilce izlerinin ve lekelerinin tedavisinde
oldukça etkili olmasyla da dikkat çekiyor. Bunun nedeni ise anti-enflamatuar özellikte bir vitamin olmas. 2013 tarihli International Journal of Dermatology
çalmas buna ahane bir örnek. Çalmada akne sorunu yaayan bireylere 8 hafta boyunca günde 2 kere niacinamide uygulanm. Aratrma sonunda niacinamide’in
bir çeit antibiyotik gibi etki gösterdii ve akneli cildi yattrd gözleniyor.

Niacinamide içeren cilt bakm ürünleri erken yalanma belirtilerinin önüne geçmede de oldukça etkili. Cildin en alt tabakasna kadar inebilen niacinamide,
deri altndaki kolajen dokuyu uyaryor ve aktive ediyor. Niacinamide Cildi çabuk kzaran ya da roza benzeri cilt sorunlar yaayan hassas ciltler için de oldukça ideal.
Cilt bariyerini korurken cilt yüzeyini de pürüzsüzletiriyor, gözeneklerin sklamasna yardmc oluyor. Yeil çayl tonik içerisindeki niacinamide sayesinde
cildin canlanmasna yardmc oluyor, cilt yalanmasnn önüne geçerek sivilce sorunlarn da önlüyor. Salyangoz özü ve niacinamide göz çevresinin onarlmasna
ve koruyucu bariyerinin güçlenmesine yardmc. Cilt esnekliini artran, bariyeri güçlendiren ve renk deiimlerini ortadan kaldrmaya yardmc olan niacinamide
ite bu nedenle etkili güne koruyucu ürünlerin içeriinde de kendisine yer bulmu.

Tüketici laç Bilgileri
Lisans verileri US DailyMed: Niasinamid
Gebelik kategorisi ABD: C (Risk göz ard edilmemitir) [1]
Az yoluyla uygulama yollar, topikal
ATC kodu A11HA01 (WHO)

Tanmlayclar Niasinamid

CAS Numaras 98-92-0 ☑
PubChem CID 936
drugbank DB02701
ChemSpider 911
UNII 25X51I8RD4
KEGG D00036
CHEBI 17154
ChEMBL ChEMBL1140

Kimyasal ve fiziksel veriler Niasinamid
Formül C6H6N2O
Molar kütle 122.127 g · mol – 1
Younluk 1,40 g / cm3 [2] g / cm3
Erime noktas 129.5 ° C (265.1 ° F)
Kaynama noktas 334 ° C (633 ° F)

Nikotinamid (Niasinamid)
Niasinamid olarak da bilinen nikotinamid (NAM), gdalarda bulunan ve bir diyet takviyesi ve ilaç olarak kullanlan bir B3 vitamini türüdür. [3] [4] [5] Ek olarak, pellagra (niasin eksiklii) önlemek ve tedavi etmek için az tarafndan kullanlr. [4] Nikotinik asit (niasin) bu amaç için kullanlabilse de, nikotinamid cildin kzarmasna neden olmama yararna sahiptir. [4] Bir krem olarak, akne tedavisinde kullanlr. [5]
Yan etkiler minimaldir. [6] [7] Yüksek dozlarda karacier problemleri ortaya çkabilir. [6] Normal miktarlar hamilelik srasnda güvenlidir. [1] Nikotinamid, B vitamini ilaç ailesinde, özellikle B3 vitamini kompleksindedir. [8] [9] Nikotinik asidin bir amididir. [6] Nikotinamid içeren gdalar arasnda maya, et, süt ve yeil sebzeler bulunur. [10]
Nikotinamid 1935 ve 1937 arasnda kefedildi. [11] [12] Bir salk sisteminde ihtiyaç duyulan en güvenli ve en etkili ilaçlar olan Dünya Salk Örgütü Temel laçlar Listesi’ndedir. [13] Nikotinamid jenerik ilaç olarak ve reçetesiz satlmaktadr. [8] Birleik Krallk’ta 60 g’lk bir tüp NHS’ye yaklak 7,10 £ ‘a mal oluyor. [5] Ticari olarak nikotinamid, nikotinik asit veya nikotinonitrilden yaplr. [12] [14] Baz ülkelerde tahllara nikotinamid eklenir.
Niasinamid, B3 vitamininin aktif formudur ve koenzim nikotinamid adenin dinükleotidinin (NAD) bir bileenidir. Niasinamid, tümör kan akn arttrarak, böylece tümör hipoksisini azaltarak bir kemo ve radyo-duyarllatrc ajan olarak ilev görür. Bu ajan ayrca, radyasyon veya kemoterapi ile indüklenen DNA iplik kopmalarnn yeniden birlemesine katlan enzimler olan poli (ADP-riboz) polimerazlar da inhibe eder.

Nikotinamid- Niasinamid, 3. pozisyondaki hidrojenin bir karboksamid grubu ile deitirildii piridin olan bir piridininkarboksamiddir. Bir EC 2.4.2.30 (NAD (+) ADP-ribosiltransferaz) inhibitörü, bir metabolit, bir kofaktör, bir antioksidan, bir nöroprotektif ajan, bir EC 3.5.1.98 (histon deasetilaz) inhibitörü, bir anti-enflamatuar ajan olarak rol oynar. , bir Sir2 inhibitörü, bir Saccharomyces cerevisiae metaboliti, bir Escherichia coli metaboliti ve bir fare metaboliti. Bir piridinkarboksamid ve bir piridin alkaloididir. Bir nikotinik asitten türetilir.

Niasin ve niasinamid, niasin eksikliini önlemek ve pellagray tedavi etmek için kullanlr. Baz klinisyenler vazodilatasyon etkilerinden yoksun olduu için pellagra tedavisi için niasinamidi tercih ederler. Pellagra, diyet eksiklii, izoniazid tedavisi veya Hartnup hastalnda veya karsinoid tümörlerde triptofann niasine dönüümünün azalmasndan kaynaklanabilir. / ABD ürün etiketine dahildir /

Her ne kadar niasin ve niasinamid’in iyi kontrollü çalmalarla terapötik deere sahip olduu gösterilmese de, ilaçlar izofrenik bozukluk, ilaca bal halüsinasyonlar, kronik beyin sendromu, hiperkinezi, tek kutuplu depresyon, hareket hastal, alkol bamll, yaamak vaskülit, akne ve cüzzam. / ABD ürün etiketine dahil DEL /
Tbbi kullanmlar
Niasin eksiklii
Nikotinamid-Niasinamid, niasin eksikliinin neden olduu pellagra için tercih edilen tedavidir. [4] Niasin kullanlabilmesine ramen, nikotinamid ciltte kzarkla neden olmama yararna sahiptir. [4]

Akne
Akne tedavisinde nikotinamid-Niasinamid krem kullanlr. [5] nflamatuar cilt rahatszlklar olan insanlara fayda salayabilecek anti-enflamatuar etkileri vardr. [15]

Nikotinamid-Niasinamid in vitro insan keratinositlerinde seramidlerin biyosentezini arttrr ve in vivo epidermal geçirgenlik bariyerini gelitirir. [16] 2 ve 4 hafta boyunca% 2 topikal nikotinamid uygulamasnn sebum atlm orann düürmede etkili olduu bulunmutur. [17] Nikotinamidin, sonuçta pro-enflamatuar interlökin-8 üretiminin aa regülasyonu ile sonuçlanan otoyol benzeri reseptör 2’nin Cutibacterium acnes kaynakl aktivasyonunu önledii gösterilmitir. [18]

Cilt kanseri Niasinamid
Günde 500 ila 1000 mg’lk dozlarda nikotinamid-Niasinamid, yüksek risk altnda olanlarda melanom dndaki cilt kanseri riskini azaltr. [19]

Yan etkiler Niasinamid
Nikotinamidin minimal yan etkileri vardr. [6] [7] Yüksek dozlarda karacier problemleri ortaya çkabilir. [6] Hamilelik srasnda normal dozlar güvenlidir. [1]

Kimya-Niacinamide
Nikotinamidin yaps, bir birincil amid grubunun meta pozisyonunda tutulduu bir piridin halkasndan oluur. Nikotinik asidin bir amididir. [6] Aromatik bir bileik olarak, elektrofilik yerdeitirme reaksiyonlarna ve iki fonksiyonel grubunun dönüümlerine urar. Organik Sentezlerde bildirilen bu reaksiyonlarn örnekleri arasnda, nikotinonitrilden N-oksit yoluyla fosfor pentoksit, [22] ve bir sodyum hipobromit çözeltisi ile reaksiyon yoluyla 3-aminopiridinden iki aamal bir ilemle 2-kloronikotinonitrilin hazrlanmas yer alr. , yerinde brom ve sodyum hidroksitten hazrlanmtr

Niasinamidin endüstriyel üretimi
Nikotinonitrilin hidrolizi, Rhodococcus rhodochrous J1’den gelen nitril hidrataz enzimi tarafndan katalize edilir, [24] [25] [14], hayvan yeminde kullanm için ylda 3500 ton nikotinamid üretir. [26] Amidin nikotinik aside hidrolizinden kaçnldndan, enzim daha seçici bir sentez salar. [27] [28] Nikotinamid ayrca nikotinik asitten de yaplabilir. Ullmann’n Endüstriyel Kimya Ansiklopedisine göre, 2014 ylnda dünya çapnda 31.000 ton nikotinamid satld. [12]

Biyokimya Nikotinamid

NAD + molekülü üzerindeki aktif Nikotinamid grubu birçok metabolik yolda oksidasyona urar.
Koenzim nikotinamid adenin dinükleotidinin (NADH / NAD +) bir parças olarak nikotinamid yaam için çok önemlidir. Hücrelerde nikotinamid, NAD + ve nikotinamid adenin dinükleotid fosfat (NADP +) içine dahil edilir. NAD + ve NADP +, çok çeitli enzimatik oksidasyon-indirgeme reaksiyonlar, en önemlisi glikoliz, sitrik asit döngüsü ve elektron tama zincirinde koenzimlerdir. [29] nsanlar nikotinamidi yutarsa, muhtemelen NAD’ye dönütüren bir dizi reaksiyona girecek ve bu da daha sonra NADP + oluturmak için bir dönüüm geçirebilir. Bu NAD + oluturma yöntemine kurtarma yolu denir. Bununla birlikte, insan vücudu, nikotinamid almmz olmadan amino asit triptofan ve niasinden NAD + üretebilir. [30]

NAD +, Niasinamid enerjisinin besinler ile hücrenin enerji para birimi adenozin trifosfat (ATP) arasnda dönüümüne yardmc olan bir elektron taycs olarak ilev görür. Oksidasyon-indirgeme reaksiyonlarnda, koenzimin aktif ksm nikotinamiddir. NAD + ‘da, aromatik nikotinamid halkasndaki azot adenin dinükleotidine kovalent olarak balanr. Azot üzerindeki resmi yük, aromatik halkadaki dier karbon atomlarnn paylalan elektronlar tarafndan stabilize edilir. NAD + oluturmak için NAD + üzerine bir hidrit atomu eklendiinde, molekül aromatikliini ve dolaysyla iyi bir stabilite kaybn kaybeder. Bu yüksek enerji ürünü daha sonra enerjisini bir hidrit salnm ile serbest brakr ve elektron tama zinciri durumunda, adenosin trifosfatn oluturulmasna yardmc olur. [31]

Bir mol NADH oksitlendiinde 158.2 kJ enerji aça çkacaktr. [31]

Biyolojik rol
Nikotinamid, B vitamini ailesi ve özellikle B3 vitamini kompleksi dahil olmak üzere çeitli biyolojik sistemlerin bir bileeni olarak ortaya çkar. [8] [9] Ayn zamanda, oksitlenmi NAD + formundaki N-ikameli aromatik halkann, NADH oluturmak için hidrit saldrs ile indirgeme geçirdii NADH ve NAD + yaplarnn kritik öneme sahip bir parçasdr. [29] NADPH / NADP + yaplar ayn halkaya sahiptir ve benzer biyokimyasal reaksiyonlarda yer alr.

Gda kaynaklar Nikotinamid-Niasinamid
Nikotinamid az miktarda et, balk, fndk ve mantarlarda olduu gibi baz sebzelerde de az miktarda bulunur. [32] Genellikle tahllara ve dier yiyeceklere eklenir. Birçok multivitamin, 20-30 mg B3 vitamini içerir ve daha yüksek dozlarda da bulunur. [33]

Karlatrmal durum Niasinamid- Nikotinamid
ngiliz Farmakopesi [34]
Japon Farmakopesi [35]

Aratrma-Niacinamide
2015 ylnda yaplan bir çalmada, nikotinamidin, yüksek risk altndaki bir grup insanda yeni melanom d cilt kanseri ve aktinik keratoz orann azaltt bulunmutur. [36]
Nikotinamid, büllöz pemfigoid nonmelanoma cilt kanserlerinin tedavisi de dahil olmak üzere birçok ek bozukluk için aratrlmtr. [37]
Niasinamid, sedef hastalnn tedavisinde faydal olabilir. [38]
Akne, rosacea, otoimmün kabarcklanma bozukluklar, yalanan cilt ve atopik dermatit tedavisinde nikotinamidin potansiyel bir rolü için geçici kantlar vardr. [37] Niasinamid ayrca radyasyon veya kemoterapi ile indüklenen DNA iplii kopmalarnn yeniden birlemesine katlan enzimler olan poli (ADP-riboz) polimerazlar (PARP-1) de inhibe eder. [39] ARCON (hzlandrlm radyoterapi art karbojen inhalasyonu ve nikotinamid) kanserde çallmtr. [40]

Niasinamid nedir?
Nikotinamid olarak da adlandrlan niasinamid, temel bir besin maddesi olan B-3 vitamini formudur. B-3 eksiklii cilt, böbrek ve beyin bozukluklarna yol açabilir. Niasinamid almak B-3 eksikliini önlemeye yardmc olabilir.

Ve özellikle genel cilt sal söz konusu olduunda, bu besin maddesi üzerinde çok daha fazlas var. Daha fazla aratrmaya ihtiyaç duyulmasna ramen, topikal niasinamid akne ve egzama dahil olmak üzere belirli cilt durumlarnn tedavisinde yardmc olabilir.

Avantajlar, ürünlerde nelerin aranaca ve daha fazlas hakknda daha fazla bilgi edinmek için okumaya devam edin.

Bu niasin ile ayn ey mi?
simlerdeki benzerliklere ramen, niasinamid niasin ile ayn ey deildir. ki farkl B-3 vitamini türüdür.

Bununla birlikte, vücudunuz aldnz niasin takviyelerinden niasinamid yapabilir. Bu, vücutta ar miktarda niasin olduunda olur. Vücuttaki triptofan da niasinamide dönütürülebilir.

B-3 vitamini veya dier takviyeleri almadan önce her zaman bir doktorla konumalsnz.

Niasinamid ne gibi yararlar salar?
Genel olarak, niasinamid, ciltteki proteinlerin oluturulmasna ve çevresel hasar önlemek için nemin kilitlenmesine yardmc olabilir.

Bireysel faydalar unlar içerir:

Baklk. Niasinamid, cildinizi salam ve salkl tutan bir protein türü olan keratinTrusted Source’un oluturulmasna yardmc olur.
Lipid bariyeri. Niasinamid, cildinizin bir seramid (lipit) bariyeri gelitirmesine yardmc olabilir. Bu, özellikle egzama veya olgun bir cildiniz varsa, tüm cilt tipleri için faydaldr.
Kzarkl ve lekeleri en aza indirir. Niasinamid iltihab azaltr Egzama, akne ve dier iltihapl cilt durumlarndan kzarkl hafifletmeye yardmc olabilecek Güvenceli Kaynak.
Gözenek görünümünü en aza indirir. Cildi pürüzsüz ve nemli tutmak Güvenilen Kaynan ikincil bir yarar olabilir – zaman içinde gözenek boyutunda doal bir azalma.
Ya düzenler. Nem tutmann faydalar sadece kuru cilt tiplerine sahip olanlar için deildir. Niasinimid ayrca ya bezlerinin ürettii ya miktarn düzenlemeye yardmc olabilir ve bezlerin ar hza girmesini önleyebilir.
Güne hasarna kar korur. Niasinamid ayn zamanda salkl cilt hücrelerini ayn zamanda yeniden oluturabilir ve ayn zamanda onlar ultraviyole nlarnn neden olduu hasarlardan koruyabilir.
Hiperpigmentasyonu tedavi eder. Baz aratrmalar, yüzde 5 niasinamid konsantrasyonlarnn karanlk noktalarn aydnlatlmasnda yardmc olabileceini bulmutur.

Faydalar dört hafta sonra görülmütür, ancak iki aydan fazla görülmemitir. Bu fayda artan kollajen üretiminden kaynaklanyor olabilir.
nce çizgileri ve krklklar en aza indirir. Aratrmalar, ayn konsantrasyonun yalanma ile birlikte gelen baz güne hasar belirtilerini azaltmada yardmc olduunu bulmutur. Buna ince çizgiler ve krklklar dahildir.
Oksidatif strese kar korur. Niasinamid, cildin hücrelerinin oluturulmasna yardmc olurken, güne , kirlilik ve toksinler gibi çevresel streslerden de korur.

Dengeli bir diyet yemek, B-3 vitamini gibi mikro besinleri almann en iyi yoludur. Eksiklii tedavi etmek için sadece tbbi gözetim altnda takviyeler almalsnz.

Genel cilt sal söz konusu olduunda, niasinamidin baz faydalarn yediiniz yiyeceklerden alabilirsiniz.

B-3 vitamini, Niasinamid’de bulunur:

yumurtalar
hububat
yeil sebzeler
Fasulyeler
balk
Süt
Bununla birlikte, diyetinizdeki besin maddelerinin genel cilt salnz etkilediini garanti etmenin bir yolu yoktur. Niasinamid’in cilt bakm endielerinizi hedeflemesini salamann tek yolu onu topikal olarak kullanmaktr.

Cilt bakm ürünü türü veya rutininizde kullanld zaman önemli mi?
Birçok topikal niasinamid ürünü serum eklinde gelir. Serumlar, düzenli temizlik, tonlama ve nemlendirme dndaki cilt sorunlarna yönelik ekstra tedaviler olarak düünün.

Niasinamid serumunuz tonlamadan sonra ancak nemlendirmeden önce uygulanmaldr.

Baz temizleyiciler ve kremler ayrca niasinamid içerir. Bu bileen, her kullanmdan sonra durulanan baz yüz maskelerinde de bulunur.

Her ürün etiketini dikkatle okuyun ve tüm kullanm talimatlarn izleyin.

Niasinamid maksimum etki için dier cilt bakm bileenleri ile birletirilebilir mi?
Niasinamid, optimal sonuçlar için dier aktif bileenlerin yannda kullanlabilir.

Örnein, Niasinamid baz raporlar, takviye edici niasinamidin akne tedavisinde bakr, folik asit ve çinko ile birlikte iyi çalabileceini düündürmektedir.

Hiyalüronik asit ile birlikte niasinamid serumunuzdan daha fazla yararlanabilirsiniz. Hyaluronik asidin ürün emilimini arttrd söylenir.

Niasinamide yan etkisi riski var m?
Topikal niasinamidin genellikle güvenli olduu düünülmektedir.

Önceden var olan alerjileri olan kiilerin alerjik reaksiyon yaama olasl daha yüksektir. Çünkü niasinamid vücudunuzun histamin salglamasna neden olabilir.

Bir yama testi yaparak yaygn alerjik reaksiyonlar ve ürün hassasiyetlerini önleyebilirsiniz:

Önkolunuza dime boyutlu bir ürün uygulayn.
24 saat bekleyin.
Kzarklk, kant veya ilik yaamaya balarsanz, alan ykayn ve kullanmay brakn.
Herhangi bir yan etki yaamyorsanz, baka bir yere uygulamak güvenli olmaldr.
Ne gibi sonuçlar bekleyebilirsiniz?
Herhangi bir yeni cilt bakm ürününde olduu gibi, muhtemelen birkaç hafta boyunca önemli bir sonuç görmeyeceksiniz.

Her ne kadar Niacinamide mevcut aratrmalarn çou dört haftalk kullanmdan sonra gözle görülür iyilemeleri tanmlasa da kesin bir zaman çizelgesi yoktur.

Sekiz hafta sonra cildinizde daha da fazla deiiklik görebilirsiniz. Bu daha pürüzsüz, tonlanm ve nemlendirilmi cildi içerir.

Birkaç ay içinde herhangi bir deiiklik görmezseniz, bir dermatoloa danmann zaman gelmi olabilir. Cilt bakm rutininizi deerlendirebilir ve hangi ürünlerin kullanlacan, cilt salnz iyiletirebilecek diyet deiikliklerini ve daha fazlasn önerebilirler.

Sonuç olarak Niasinamid
Topikal olarak her gün kullanldnda, niasinamidin genel cilt salnz üzerinde olumlu bir etkisi olabilir. Bileen, iltihab ve hiperpigmentasyonu azaltmaya yardmc olabilir, genel cilt dokunuzu pürüzsüzletirebilir ve cildinizi aydnlatabilir.

Göze çarpan bir iyileme görmek birkaç hafta sürebilir, bu nedenle sabrl olmak ve rutininize bal kalmak önemlidir.

Doktorunuz veya dier salk uzmannz B-3 eksikliini veya altta yatan baka bir durumu tedavi etmek için reçete etmedikçe niasinamid takviyeleri almamalsnz.

SALIK KAYNAKLARI Niasinamid
htiyacnz olan vitaminleri yiyeceklerle aln
Her gün ne kadar A, B, C, D, E ve K’ye ihtiyacnz olduunu ve bunlar nereden alacanz örenin. Market alverii yaparken veya yemek hazrlarken referans olmas için ücretsiz klavuzumuzu indirin.

Sivilceleri tedavi eder. Niasinamid, iddetli akne, özellikle papüller ve püstüller gibi enflamatuar formlar için yararl olabilir. Zamanla, daha az lezyon ve gelimi cilt dokusu görebilirsiniz.

Niasinamid’in (B3 Vitamini) cilt lekelerinin ve tkanklklarn görünümünü azaltt belirtilmektedir. Bu vitaminin yüksek% 10’luk bir konsantrasyonu, sebum aktivitesinin görünür yönlerini dengelemek için pirolidon karboksilik asidin çinko tuzu ile formülde desteklenir.

Kontrendikasyonlar: Cilt bakmnn bir parças olarak topikal C Vitamini (L-Askorbik Asit ve / veya Etillenmi L-Askorbik Asit) kullanlrsa, bu formülle (PM’de ideal C vitamini ve AM’de bu formül) alternatif zamanlarda uygulanmaldr. ). Aksi takdirde, Niasinamid C Vitamini bütünlüünü etkileyebilir.

Notlar: Niasinamid ve Zinc PCA, lekelerin görünümünü azaltr ve görünür sebum aktivitesini dengelerken, ikisi de akne tedavisi deildir. Akne ile ilgili kalc durumlar için Benzoil Peroksit ve / veya Retinoik Asit kullanlmasn öneririz. DECIEM, kalc lekeler için sürekli Salisilik Asit gibi BHA kullanlmasn önermez. Lekelerin görünümünde geçici iyileme için Salisilik Asit yardmc olacaktr. Bu formülasyon, ilave görünür cilt yararlar için istenirse akne tedavilerinin yannda kullanlabilir.
Bamsz çalmalar, Niasinamid’in cilt tonunu aydnlatmak için etkili bir bileen olduunu göstermektedir.

Niacinamide Yol Tarifi
Daha ar kremlerden önce sabah ve akam tüm yüze uygulayn. Tahri olursa, kullanmay brakn ve bir doktora dann. Sadece krlmam ciltlere yönelik kullann. Kullanmadan önce yama testi yaplmas önerilir. Yama testi için ayrntl klavuzumuza bakn. Çocuklarn eriemeyecei yerlerde saklayn.

Niasinamid Bileenleri
Aqua (Su), Niasinamid, Pilenilen Glikol, Çinko PCA, Dimetil zosorbit, Tamarindus Indica Tohum Sakz, Ksantan sakz, zosetet-20, Etoksidiglikol, Fenoksietanol, Klorfenesin.

novasyona olan ballmzn bir parças olarak formülasyonlarmz zaman zaman güncellenir.

Niasinamid’i Cilt Bakm Rutinime Nasl Girmeliyim?
Her zaman olduu gibi, bir yama testi yaparak balayn. Seçtiiniz niasinamid ürününü birkaç gün üst üste küçük bir cilt bölgesine uygulayn. Herhangi bir olumsuz reaksiyon meydana gelmezse, devam edebilirsiniz.

Niasinamid’i cilt bakm rutininize tamamen tanttktan sonra, uyguladnz zaman baka ne kullandnza ve ne tür bir dokuya geldiine baldr. Niasinamid nispeten daha yüksek bir pH’ta etkili olduundan, kesinlikle daha sonra kullanmak istersiniz. pH’a bal aktifleriniz, örnein AHA, BHA veya C vitamini.

Aslnda, rutininiz temizlik ve niasinamid ile bir nemlendirici uygulamak kadar basit olabilir veya temizlik, tonlama, kimyasal eksfoliant uygulamak, baka bir aktif uygulamak, niasinamid ile bir serum uygulamak ve daha sonra bir nemlendirici kadar karmak olabilir. . Bu tamamen size bal.

Niasinamid cildi a duyarl hale getirmezken, ayn zamanda günee maruz kalmaya kar koruyucu önlemler almazken kullanm amacn yendiini düünüyorum.

C Vitamini niasinamid ile Eletirebilir miyim?
Ksa cevap evet. Uzun cevap da evet, ama biraz dikkatli. Hem C vitamini hem de niasinamid içeren ürünler cildin temas ettiinde kzarmasna neden olabilir, ancak bu reaksiyon cilde zarar vermez ve yaklak 20 dakika sonra kaybolur.

Bu tür reaksiyonlarn, C vitamini ve niasinamid iki farkl üründe mevcut olduunda ortaya çkma olasl daha düüktür. Bununla birlikte, bir reaksiyon fark ederseniz, ürünleri gün boyunca dierini akamlar kullanarak ayr olarak kullanmay seçebilirsiniz.

En yi Niasinamid Cilt Bakm Ürünlerini Bulma
Niasinamidli cilt bakm ürününün cilt üzerinde gerçekten bir etkisi olmas için, formülde etkili bir konsantrasyonda bulunmas gerekir. Cildi tahri etmeden gerçekten% 2 ila% 5 arasnda bir fark yaratmak yeterlidir.

Genellikle bu, niasinamidin içerikler listesinde 4. veya 5. bileen olmasn istediiniz anlamna gelir. Piyasadaki en iyi niasinamid ürünlerini farkl fiyat noktalarnda seçtim ve hepsinin bu inanlmaz içeriin yeterli bir miktarn içerdiini garanti ediyorum.

1. CeraVe Yüz Nemlendirici Niasinamid Losyon PM
CeraVe hemen hemen her cilt bakm derlemesine girer, çünkü genel olarak en iyi ürünlerden bazlarn ve özellikle de en iyi niasinamid ürünlerinden bazlarn yaparlar. Bu gece nemlendiricisinde% 4 niasinamid ve ayn zamanda seramidler ve hiyalüronik asit gibi cildi taklit eden ve nemlendiren birkaç baka madde bulunur.

Kiinin rutinine entegre edilmesi çok kolaydr, çünkü rutininize fazladan bir cilt bakm adm eklemez. Cilde hzla nüfuz eden hafif bir dokuya sahiptir ve hem yal hem de kuru cilt tipleri (ve aradaki herkes) için iyi çalr.

Nicotinamide (Niacinamide)

Consumer Drug Information
License data US DailyMed: Niacinamide
Pregnancy category US: C (Risk not ruled out) [1]
Routes of administration by mouth, topical
ATC code A11HA01 (WHO)

Identifiers Niacinamide

CAS Number 98-92-0 ☑
PubChem CID 936
DrugBank DB02701
ChemSpider 911
UNII 25X51I8RD4
KEGG D00036
CHEBI 17154
ChEMBL ChEMBL1140

Chemical and physical data Niacinamide
Formula C6H6N2O
Molar mass 122.127 g·mol-1
Density 1.40 g/cm3[2] g/cm3
Melting point 129.5 °C (265.1 °F)
Boiling point 334 °C (633 °F)

Nicotinamide (Niacinamide)
Nicotinamide (NAM), also known as niacinamide, is a form of vitamin B3 found in food and used as a dietary supplement and medication.[3][4][5] As a supplement, it is used by mouth to prevent and treat pellagra (niacin deficiency).[4] While nicotinic acid (niacin) may be used for this purpose, nicotinamide has the benefit of not causing skin flushing.[4] As a cream, it is used to treat acne.[5]
Side effects are minimal.[6][7] At high doses liver problems may occur.[6] Normal amounts are safe for use during pregnancy.[1] Nicotinamide is in the vitamin B family of medications, specifically the vitamin B3 complex.[8][9] It is an amide of nicotinic acid.[6] Foods that contain nicotinamide include yeast, meat, milk, and green vegetables.[10]
Nicotinamide was discovered between 1935 and 1937.[11][12] It is on the World Health Organization’s List of Essential Medicines, the safest and most effective medicines needed in a health system.[13] Nicotinamide is available as a generic medication and over the counter.[8] In the United Kingdom a 60 g tube costs the NHS about £7.10.[5] Commercially, nicotinamide is made from either nicotinic acid or nicotinonitrile.[12][14] In a number of countries grains have nicotinamide added to them.
Niacinamide is the active form of vitamin B3 and a component of the coenzyme nicotinamide adenine dinucleotide (NAD). Niacinamide acts as a chemo- and radio-sensitizing agent by enhancing tumor blood flow, thereby reducing tumor hypoxia. This agent also inhibits poly(ADP-ribose) polymerases, enzymes involved in the rejoining of DNA strand breaks induced by radiation or chemotherapy.

Nicotinamide- Niacinamide is a pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a metabolite, a cofactor, an antioxidant, a neuroprotective agent, an EC 3.5.1.98 (histone deacetylase) inhibitor, an anti-inflammatory agent, a Sir2 inhibitor, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a pyridinecarboxamide and a pyridine alkaloid. It derives from a nicotinic acid.

Niacin and niacinamide are used to prevent niacin deficiency and to treat pellagra. Some clinicians prefer niacinamide for the treatment of pellagra because it lacks vasodilating effects. Pellagra may result from dietary deficiency, isoniazid therapy, or from decreased conversion of tryptophan to niacin in Hartnup disease or carcinoid tumors. /Included in US product label/

Although niacin and niacinamide have not been shown by well-controlled trials to have therapeutic value, the drugs have been used for the management of schizophrenic disorder, drug-induced hallucinations, chronic brain syndrome, hyperkinesis, unipolar depression, motion sickness, alcohol dependence, livedoid vasculitis, acne, and leprosy. /NOT included in US product label/
Medical uses
Niacin deficiency
Nicotinamide-Niacinamide is the preferred treatment for pellagra, caused by niacin deficiency.[4] While niacin may be used, nicotinamide has the benefit of not causing skin flushing.[4]

Acne
Nicotinamide-Niacinamide cream is used as a treatment for acne.[5] It has anti-inflammatory actions, which may benefit people with inflammatory skin conditions.[15]

Nicotinamide-Niacinamide increases the biosynthesis of ceramides in human keratinocytes in vitro and improves the epidermal permeability barrier in vivo.[16] The application of 2% topical nicotinamide for 2 and 4 weeks has been found to be effective in lowering the sebum excretion rate.[17] Nicotinamide has been shown to prevent Cutibacterium acnes-induced activation of toll-like receptor 2, which ultimately results in the down-regulation of pro-inflammatory interleukin-8 production.[18]

Skin cancer Niacinamide
Nicotinamide-Niacinamide at doses of 500 to 1000mg a day decreases the risk of skin cancers, other than melanoma, in those at high risk.[19]

Side effects Niacinamide
Nicotinamide has minimal side effects.[6][7] At high doses liver problems may occur.[6] Normal doses are safe during pregnancy.[1]

Chemistry-Niacinamide
The structure of nicotinamide consists of a pyridine ring to which a primary amide group is attached in the meta position. It is an amide of nicotinic acid.[6] As an aromatic compound, it undergoes electrophilic substitution reactions and transformations of its two functional groups. Examples of these reactions reported in Organic Syntheses include the preparation of 2-chloronicotinonitrile by a two-step process via the N-oxide from nicotinonitrile by reaction with phosphorus pentoxide,[22] and from 3-aminopyridine by reaction with a solution of sodium hypobromite, prepared in situ from bromine and sodium hydroxide

Industrial production of Niacinamide
The hydrolysis of nicotinonitrile is catalysed by the enzyme nitrile hydratase from Rhodococcus rhodochrous J1,[24][25][14] producing 3500 tons per annum of nicotinamide for use in animal feed.[26] The enzyme allows for a more selective synthesis as further hydrolysis of the amide to nicotinic acid is avoided.[27][28] Nicotinamide can also be made from nicotinic acid. According to Ullmann’s Encyclopedia of Industrial Chemistry, worldwide 31,000 tons of nicotinamide were sold in 2014.[12]

Biochemistry Nicotinamide

The active Nicotinamide group on the molecule NAD+ undergoes oxidation in many metabolic pathways.
Nicotinamide, as a part of the coenzyme nicotinamide adenine dinucleotide (NADH / NAD+) is crucial to life. In cells, nicotinamide is incorporated into NAD+ and nicotinamide adenine dinucleotide phosphate (NADP+). NAD+ and NADP+ are coenzymes in a wide variety of enzymatic oxidation-reduction reactions, most notably glycolysis, the citric acid cycle, and the electron transport chain.[29] If humans ingest nicotinamide, it will likely undergo a series of reactions that transform it into NAD, which can then undergo a transformation to form NADP+. This method of creation of NAD+ is called a salvage pathway. However, the human body can produce NAD+ from the amino acid tryptophan and niacin without our ingestion of nicotinamide.[30]

NAD+ acts as an electron carrier that helps with the interconversion of Niacinamide energy between nutrients and the cell’s energy currency, adenosine triphosphate (ATP). In oxidation-reduction reactions, the active part of the coenzyme is the nicotinamide. In NAD+, the nitrogen in the aromatic nicotinamide ring is covalently bonded to adenine dinucleotide. The formal charge on the nitrogen is stabilized by the shared electrons of the other carbon atoms in the aromatic ring. When a hydride atom is added onto NAD+ to form NADH, the molecule loses its aromaticity, and therefore a good amount of stability. This higher energy product later releases its energy with the release of a hydride, and in the case of the electron transport chain, it assists in forming adenosine triphosphate.[31]

When one mole of NADH is oxidized, 158.2 kJ of energy will be released.[31]

Biological role
Nicotinamide occurs as a component of a variety of biological systems, including within the vitamin B family and specifically the vitamin B3 complex.[8][9] It is also a critically important part of the structures of NADH and NAD+, where the N-substituted aromatic ring in the oxidised NAD+ form undergoes reduction with hydride attack to form NADH.[29] The NADPH/NADP+ structures have the same ring, and are involved in similar biochemical reactions.

Food sources Nicotinamide-Niacinamide
Nicotinamide occurs in trace amounts mainly in meat, fish, nuts, and mushrooms, as well as to a lesser extent in some vegetables.[32] It is commonly added to cereals and other foods. Many multivitamins contain 20-30 mg of vitamin B3 and it is also available in higher doses.[33]

Compendial status Niacinamide- Nicotinamide
British Pharmacopoeia[34]
Japanese Pharmacopoeia[35]

Research-Niacinamide
A 2015 trial found nicotinamide to reduce the rate of new nonmelanoma skin cancers and actinic keratoses in a group of people at high risk for the conditions.[36]
Nicotinamide has been investigated for many additional disorders, including treatment of bullous pemphigoid nonmelanoma skin cancers.[37]
Niacinamide may be beneficial in treating psoriasis.[38]
There is tentative evidence for a potential role of nicotinamide in treating acne, rosacea, autoimmune blistering disorders, ageing skin, and atopic dermatitis.[37] Niacinamide also inhibits poly(ADP-ribose) polymerases (PARP-1), enzymes involved in the rejoining of DNA strand breaks induced by radiation or chemotherapy.[39] ARCON (accelerated radiotherapy plus carbogen inhalation and nicotinamide) has been studied in cancer.[40]

What is niacinamide?
Niacinamide, also called nicotinamide, is a form of vitamin B-3, an essential nutrient. A B-3 deficiency can lead to disorders of the skin, kidneys, and brain. Taking niacinamide can help prevent B-3 deficiency.

And there’s much more to this nutrient, especially when it comes to general skin health. Although more research is needed, topical niacinamide may help treat certain skin conditions, including acne and eczema.

Read on to learn more about its benefits, what to look for in products, and more.

Is this the same thing as niacin?
Despite the similarities in names, niacinamide isn’t the same thing as niacin. They’re two different types of vitamin B-3.

However, your body can make niacinamide from niacin supplements you’ve taken. This happens when there’s an excessive amount of niacin in the body. Tryptophan in the body can also be converted into niacinamide.

You should always talk to a doctor before taking vitamin B-3 or other supplements.

What benefits does niacinamide offer?
Overall, niacinamide can help build proteins in the skin and lock in moisture to prevent environmental damage.

Individual benefits include:

Immunity. Niacinamide helps build keratinTrusted Source, a type of protein that keeps your skin firm and healthy.
Lipid barrier. Niacinamide can help your skin grow a ceramide (lipid) barrierTrusted Source, which can, in turn, helps retain moisture. This is beneficial for all skin types, especially if you have eczema or mature skin.
Minimizes redness and blotchiness. Niacinamide reduces inflammationTrusted Source, which may help ease redness from eczema, acne, and other inflammatory skin conditions.
Minimizes pore appearance. Keeping skin smooth and moisturizedTrusted Source may have a secondary benefit – a natural reduction in pore size over time.
Regulates oil. The benefits of moisture retention aren’t just for those with dry skin types. Niacinimide can also help regulate the amount of oil the sebaceous glands produce and prevent your glands from going into overdrive.
Protects against sun damage. Niacinamide can concurrently rebuild healthy skin cells while also protecting them from damage caused by ultraviolet rays.
Treats hyperpigmentation. Some research has found 5 percent niacinamide concentrations can be helpful in lightening dark spots.

Benefits were seen after four weeks, but not beyond two months. This benefit may be due to increased collagen production.
Minimizes fine lines and wrinkles. Research has also found that the same concentration was helpful in reducing some signs of sun damage that come with aging. This includes fine lines and wrinkles.
Protects against oxidative stress. Niacinamide helps build cells in the skin while also protecting them from environmental stresses, such as sunlight, pollution, and toxins.

Eating a balanced diet is the best way to get micronutrients like vitamin B-3. You should only take supplements under medical supervision to treat deficiency.

When it comes to general skin health, you may obtain some of the benefits of niacinamide from the foods that you eat.

Vitamin B-3 is found in Niacinamide:

eggs
cereals
green veggies
beans
fish
milk
However, there’s no way to guarantee that the nutrients in your diet are impacting your overall skin health. The only way to ensure that niacinamide is targeting your skin care concerns is to use it topically.

Does the type of skin care product matter or when it’s used in your routine?
Many topical niacinamide products come in the form of serums. Think of serums as extra treatments that address individual skin concerns outside of regular cleansing, toning, and moisturizing.

Your niacinamide serum should be applied after toning but before moisturizing.

Some cleansers and creams also contain niacinamide. This ingredient is also found in some face masks, which are rinsed off after each use.

Read each product label carefully and follow all instructions for use.

Can niacinamide be combined with other skin care ingredients for maximum effect?
Niacinamide may be used alongside other active ingredients for optimal results.

For example,Niacinamide some reports suggest that supplemental niacinamide may work well alongside copper, folic acid, and zinc to treat acne.

You may be able to get more out of your niacinamide serum by using it alongside hyaluronic acid. Hyaluronic acid is said to increase product absorption.

Is there any risk of side effects Niacinamide ?
Topical niacinamide is generally considered safe to use.

People who have preexisting allergies may be more likely to experience an allergic reaction. This is because niacinamide can cause your body to release histamine.

You can avoid widespread allergic reactions and product sensitivities by doing a patch test:

Apply a dime-sized amount of product on your forearm.
Wait 24 hours.
If you begin to experience redness, itching, or swelling, wash the area and discontinue use.
If you don’t experience any side effects, it should be safe to apply elsewhere.
What results can you expect?
As with any new skin care product, you probably won’t see any significant results for several weeks.

Although Niacinamide most of the available research describes noticeable improvements after four weeks of use, there’s no exact timeline.

You may see even more changes to your skin after eight weeks. This includes smoother, toned, and hydrated skin.

If you don’t see any changes within a couple of months, it may be time to consult with a dermatologist. They can assess your skin care routine and advise you on which products to use, dietary changes that may improve your skin health, and more.

The bottom line Niacinamide
When used topically every day, niacinamide may have a positive impact on your overall skin health. The ingredient can help reduce inflammation and hyperpigmentation, smooth your overall skin texture, and brighten your skin.

It can take several weeks to see noticeable improvement, so it’s important to be patient and to stick with your routine.

You should not take niacinamide supplements unless your doctor or other healthcare provider prescribes them to treat a B-3 deficiency or other underlying condition.

HEALTHLINE RESOURCE Niacinamide
Get the vitamins you need through food
Find out how much A, B, C, D, E, and K you need each day – and where to get them. Download our free guide to reference when you’re grocery shopping or preparing meals.

Treats acne. Niacinamide may be helpful for severe acne, especially inflammatory forms like papules and pustules. Over time, you may see fewer lesions and improved skin texture.

Niacinamide (Vitamin B3) is indicated to reduce the appearance of skin blemishes and congestion. A high 10% concentration of this vitamin is supported in the formula by zinc salt of pyrrolidone carboxylic acid to balance visible aspects of sebum activity.

Contraindications: If topical Vitamin C (L-Ascorbic Acid and/or Ethylated L-Ascorbic Acid) is used as part of skincare, it should be applied at alternate times with this formula (ideally Vitamin C in the PM and this formula in the AM). Otherwise, Niacinamide can affect integrity of the Vitamin C.

Notes: While Niacinamide and Zinc PCA reduce the look of blemishes and balance visible sebum activity, neither is a treatment for acne. For persistent acne-related conditions, we recommend the use of Benzoyl Peroxide and/or Retinoic Acid. DECIEM doesn’t recommend ongoing use of BHA such as Salicylic Acid for persistent blemishes. For temporary improvement in appearance of blemishes, Salicylic Acid would help. This formulation can be used alongside acne treatments if desired for added visible skin benefits.
Independent studies suggest Niacinamide is also an effective ingredient for brightening skin tone.

Niacinamide Directions
Apply to entire face morning and evening before heavier creams. If irritation occurs, cease use and consult a physician. Use only as directed on unbroken skin. Patch testing prior to use is advised. Refer to our in-depth guide to patch testing. Keep out of reach of children.

Niacinamide Ingredients
Aqua (Water), Niacinamide, Pentylene Glycol, Zinc PCA, Dimethyl Isosorbide, Tamarindus Indica Seed Gum, Xanthan gum, Isoceteth-20, Ethoxydiglycol, Phenoxyethanol, Chlorphenesin.

Our formulations are updated from time to time as part of our commitment to innovation. As such, the ingredient list shown here may vary from the box of the product depending on time and region of purchase
ou may not have heard of the ingredient niacinamide-a form of vitamin B3-by name, but chances are you’ve already used it on your face. The ingredient has been a staple in skin-care products for literally years, but has recently come into the spotlight as a shining star, particularly for those prone to breakouts, or for sensitive skin types. Niacinamide is also water-soluble, which makes it an easy ingredient to be added into cleansers, serums, creams or sunscreen, Shasa Hu, M.D., F.A.A.D, co-founder of BIA Life, and associate professor of dermatology at Miami University tells SELF.

Niacinamide has anti-inflammatory properties which, when applied topically, help minimize the impact of acne, and moderate rosacea. If that wasn’t impressive enough, the ingredient can also neutralize free radical damage, helping to prevent skin cancer as well as fine lines and wrinkles in the process. “The amount of niacinamide in products varies in formulations, and depends on what other ingredients are in the product,” says Marnie B. Nussbaum, M.D., Clinical Instructor of Dermatology at Weill Cornell Medical College. “There are topical formulations ranging from two percent to 10 percent.”

If you’re considering trying Niacinamide out at home but unsure where to start, check out some of these over-the-counter niacinamide products dermatologists swear by.

All products featured on SELF are independently selected by our editors. If you buy something through our retail links, we may earn an affiliate commission.
ou may not have heard of the ingredient niacinamide-a form of vitamin B3-by name, but chances are you’ve already used it on your face. The ingredient has been a staple in skin-care products for literally years, but has recently come into the spotlight as a shining star, particularly for those prone to breakouts, or for sensitive skin types. Niacinamide is also water-soluble, which makes it an easy ingredient to be added into cleansers, serums, creams or sunscreen, Shasa Hu, M.D., F.A.A.D, co-founder of BIA Life, and associate professor of dermatology at Miami University tells SELF.
Niacinamide has anti-inflammatory properties which, when applied topically, help minimize the impact of acne, and moderate rosacea. If that wasn’t impressive enough, the ingredient can also neutralize free radical damage, helping to prevent skin cancer as well as fine lines and wrinkles in the process. “The amount of niacinamide in products varies in formulations, and depends on what other ingredients are in the product,” says Marnie B. Nussbaum, M.D., Clinical Instructor of Dermatology at Weill Cornell Medical College. “There are topical formulations ranging from two percent to 10 percent.”

If you’re considering trying it out at home but unsure where to start, check out some of these over-the-counter niacinamide products dermatologists swear by.
All products featured on SELF are independently selected by our editors. If you buy something through our retail links, we may earn an affiliate commission.

There are a lot of heavy duty skin care ingredients that can seriously transform the skin, but stealthy improvement is easier to achieve, and usually comes with fewer risks. That’s why I want to shine a light on niacinamide, a fascinating skin care ingredient that can improve almost any skin concern, with virtually no potential side effects.
Unlike many other ingredients that cosmetics brands like to rave about in their marketing, there is actually a ton of research behind niacinamide that shows just how well it works. It is a magical ingredient that anyone will find useful. In this article, I’ll tell you all about it ” how niacinamide works, what it treats, how to add it to your skin care routine, and which are the best niacinamide products you can try.

What Is Niacinamide?
Niacinamide is also known as vitamin B3, or nicotinic acid. In the body, Niacinamide vitamin B3 is important for a variety of functions, including converting food into energy, maintaining blood circulation, keeping the liver, skin, hair and eyes healthy, and suppressing inflammation.

When applied topically to the skin, however, niacinamide acts as an antioxidant and improves a variety of cosmetic skin concerns. In skin care, the vitamin B3 usually comes from synthetic sources, although natural sources of it are primarily meat and fish.

What Skin Concerns Does Niacinamide Target?
• Restores compromised skin barrier functions, which look like flakey, dehydrated, or irritated skin.

• Reduces facial redness and flushing.

• Brightens dull skin tone.

• Fades surface hyperpigmentation, especially when caused by acne.

• Acts as an antioxidant to slow down the aging process and prevent free radical damage.

• Improves skin elasticity, and reduces fine lines and wrinkles.

• Minimizes the look of pores.

• Calms and reduces active acne.

• Keeps the skin looking matte.

What is interesting is that we do not fully understand exactly how niacinamide works ” we just know that it does work, based on clinical trials. For example, niacinamide restores the skin’s barrier functions both by acting as an antioxidant, as well as by increasing cell turnover rate, and natural lipid production. It likely reduces wrinkles by increasing collagen production, and reduces pigmentation by controlling the amount of pigment that is transferred from melanocytes to the skin.

The one that really has me in a doozy is niacinamide’s mattifying ability. Hundreds of people report a decrease in oil production in their skin after using niacinamide, even though there is no mechanism that explains how this might occur.

How Quickly Does Niacinamide Work?
Research conducted by Proctor and Gamble showed that after 12 weeks a product with 5% niacinamide was able to improve the appearance of various signs of skin aging, including skin elasticity, pigmentation, lines and wrinkles, and redness.

Another study, on acne, showed an improvement in just over 80% of the participants, after 8 weeks. So don’t be impatient! Use your niacinamide regularly, and know that it might take 2 or 3 months to see noticeable improvement.

Side Effects, Risks, or Concerns of Niacinamide
• Those with very sensitive skin might find themselves reacting to niacinamide at high concentrations. Possible reactions include facial flushing, and mild irritation. Reducing the percentage at which you use niacinamide, or using it less often should help.

• Some people are allergic to niacinamide. This usually manifests as redness, flushing, itching, or small (non-acne) bumps. If this occurs, stop using niacinamide.

• While generally non-comedogenic, Niacinamide some people do find that niacinamide breaks them out.

How Should I Introduce Niacinamide Into My Skin Care Routine?
As always, begin by conducting a patch test. Apply the niacinamide product of your choice to a small area of skin every day, for a few days in a row. If no adverse reaction occurs, you can keep going.

Once you fully introduce niacinamide into your skincare routine, the time when you apply it depends on what else you are using, and what kind of texture it comes in. Since niacinamide is effective at a relatively higher pH, you definitely want to use it after your pH dependent actives, like AHA, BHA, or vitamin C.

In fact, your routine could be as simple as cleansing, and applying a moisturizer with niacinamide, or it could be as complex as cleansing, toning, applying chemical exfoliant, applying another active, applying a serum with niacinamide, and then a moisturizer or two. This is totally up to you.

While niacinamide does not make the skin photosensitive, I think it defeats the purpose to use it while simultaneously not taking protective measures against sun exposure.

Can I Pair Vitamin C with Niacinamide?
The short answer is yes. The long answer is also yes, but with some care. Products that contain both vitamin C and niacinamide might cause the skin to flush on contact, but this reaction does not harm the skin and goes away after about 20 minutes.

This kind of reaction is much less likely to occur when the vitamin C and niacinamide are present in two different products. However, if you do notice a reaction, you may choose to use the products separately, using one during the day and another in the evening.

Finding The Best Niacinamide Skin Care Products
For skin care product with niacinamide to truly have an impact on the skin, it must be present in the formula at an effective concentration. Between 2% to 5% is enough to really make a difference, without irritating the skin.

Usually, this means that you want niacinamide to be the 4th or 5th ingredient on the ingredients list. I have selected the best niacinamide products on the market, at different price points, and I guarantee they all contain an adequate amount of this incredible ingredient.

1. CeraVe Facial Moisturizing Niacinamide Lotion PM
CeraVe finds its way into almost any skin care compilation, because they make some of the best products in general, and some of the best niacinamide products, specifically. This nighttime moisturizer has 4% niacinamide, as well as a few other skin mimicking and hydrating ingredients like ceramides and hyaluronic acid.

It is super easy to integrate into one’s routine, because it doesn’t add an extra skin care step to your routine. It has a light texture that penetrates quickly into the skin, and it works well for both oily and dry skin types (and anyone in between).

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