NONYLPHENOL 10 (NONLFENOL 10) (NP 10)
NONYLPHENOL 10 (NONLFENOL 10)
CAS No. : 104-40-5
EC No. : 203-199-4
Synonyms:
4-nonylphenol; 4-n-Nonylphenol; p-Nonylphenol; 104-40-5; Phenol, 4-nonyl-; para-Nonylphenol; p-n-Nonylphenol; 4-nonyl phenol; Phenol, p-nonyl-; Phenol, nonyl derivs.; Nonylphenol (mixed); p-nonyl phenol; para Nonyl phenol; p -n -Nonylphenol; 4-Nonyl-Phenol; 4-n-Nonyl phenol; CCRIS 1251; HSDB 5359; EINECS 203-199-4; BRN 2047450; 68081-86-7; DTXSID5033836; CHEBI:34440; MFCD00002396; P-NONYLPHENOL (ENDOCRINE DISRUPTER); DSSTox_CID_1857; DSSTox_RID_79098; DSSTox_GSID_33836; 4-NP; CAS-104-40-5; C9-Alkylated phenol; (C9)Alkylated phenol; UNII-I03GBV4WEL; 4-Nonylphenol (4-NP); 1-(4-Hydroxyphenyl)nonane; nonyl-phenol; p-nonyl-phenol; Para-nonyl phenol; EINECS 268-359-8; 1-Nonyl-4-phenol; 211947-56-7; Nonylphenol (4-NP); Spectrum_001973; SpecPlus_000624; Spectrum2_001832; Spectrum3_000872; Spectrum4_000712; Spectrum5_002066; 4-Nonyl Phenol-13C6; 4-n-Nonylphenol, 85%; 4-n-Nonylphenol, 98%; I03GBV4WEL; BIDD:PXR0002; SCHEMBL15887; BSPBio_002543; KBioGR_001263; KBioSS_002539; SPECTRUM330085; 3-06-00-02067 (Beilstein Handbook Reference); KSC180Q2T; BIDD:ER0006; DivK1c_006720; SPBio_001903; CHEMBL153062; CTK0I0829; KBio1_001664; KBio2_002530; KBio2_005098; KBio2_007666; KBio3_002043; 4-Nonylphenol, analytical standard; ZINC1850497; Tox21_201241; Tox21_303647; BDBM50410532; CCG-39613; LMPK15010001; LS-375; SBB059316; STL453644; AKOS015888197; MCULE-5930378829; NCGC00090918-01; NCGC00090918-02; NCGC00090918-03; NCGC00090918-05; NCGC00090918-06; NCGC00090918-07; NCGC00090918-08; NCGC00257420-01; NCGC00258793-01; FT-0619310; FT-0673035; NS00010283; ST50827096; 4-n-Nonylphenol 10 microg/mL in Acetonitrile; 4-n-Nonylphenol 10 microg/mL in Cyclohexane; 4-n-Nonylphenol 100 microg/mL in Cyclohexane; C14550; 4-Nonylphenol, PESTANAL(R), analytical standard; SR-05000002459; J-001167; Q4545806; SR-05000002459-1; 4-Nonylphenol, certified reference material, TraceCERT(R); NONYLPHENOL 6; NONYLPHENOL 8; NONYLPEHNOL 30
EN
Nonylphenol 10 (Nonilfenol 10) IUPAC Name 4-nonylphenol
Nonylphenol 10 (Nonilfenol 10) InChI 1S/C15H24O/c1-2-3-4-5-6-7-8-9-14-10-12-15(16)13-11-14/h10-13,16H,2-9H2,1H3
Nonylphenol 10 (Nonilfenol 10) InChI Key IGFHQQFPSIBGKE-UHFFFAOYSA-N
Nonylphenol 10 (Nonilfenol 10) Canonical SMILES CCCCCCCCCC1=CC=C(C=C1)O
Nonylphenol 10 (Nonilfenol 10) Molecular Formula C15H24O
Nonylphenol 10 (Nonilfenol 10) CAS 104-40-5
Nonylphenol 10 (Nonilfenol 10) Deprecated CAS 29832-11-9
Nonylphenol 10 (Nonilfenol 10) European Community (EC) Number 203-199-4
Nonylphenol 10 (Nonilfenol 10) DSSTox Substance ID DTXSID0028375
Nonylphenol 10 (Nonilfenol 10) Physical Description Solid
Nonylphenol 10 (Nonilfenol 10) Color/Form Viscous, yellow liquid
Nonylphenol 10 (Nonilfenol 10) Boiling Point 317 °C
Nonylphenol 10 (Nonilfenol 10) Melting Point 42.0 °C
Nonylphenol 10 (Nonilfenol 10) Flash Point 113 °C (235 °F) – closed cup
Nonylphenol 10 (Nonilfenol 10) Solubility 3.18e-05 M
Nonylphenol 10 (Nonilfenol 10) Density 0.950 g/cu cm at 20 °C
Nonylphenol 10 (Nonilfenol 10) Vapor Pressure 8.18e-04 mmHg
Nonylphenol 10 (Nonilfenol 10) LogP 5.76 (LogP)
Nonylphenol 10 (Nonilfenol 10) Decomposition When heated to decomposition it emits acrid smoke and irritating vapors.
Nonylphenol 10 (Nonilfenol 10) Refractive Index Index of refraction: 1.513 at 20 °C
Nonylphenol 10 (Nonilfenol 10) Molecular Weight 220.35 g/mol
Nonylphenol 10 (Nonilfenol 10) XLogP3 5.9
Nonylphenol 10 (Nonilfenol 10) Hydrogen Bond Donor Count 1
Nonylphenol 10 (Nonilfenol 10) Hydrogen Bond Acceptor Count 1
Nonylphenol 10 (Nonilfenol 10) Rotatable Bond Count 8
Nonylphenol 10 (Nonilfenol 10) Exact Mass 220.182715 g/mol
Nonylphenol 10 (Nonilfenol 10) Monoisotopic Mass 220.182715 g/mol
Nonylphenol 10 (Nonilfenol 10) Topological Polar Surface Area 20.2 Ų
Nonylphenol 10 (Nonilfenol 10) Heavy Atom Count 16
Nonylphenol 10 (Nonilfenol 10) Formal Charge 0
Nonylphenol 10 (Nonilfenol 10) Complexity 148
Nonylphenol 10 (Nonilfenol 10) Isotope Atom Count 0
Nonylphenol 10 (Nonilfenol 10) Defined Atom Stereocenter Count 0
Nonylphenol 10 (Nonilfenol 10) Undefined Atom Stereocenter Count 0
Nonylphenol 10 (Nonilfenol 10) Defined Bond Stereocenter Count 0
Nonylphenol 10 (Nonilfenol 10) Undefined Bond Stereocenter Count 0
Nonylphenol 10 (Nonilfenol 10) Covalently-Bonded Unit Count 1
Nonylphenol 10 (Nonilfenol 10) Compound Is Canonicalized Yes
Nonylphenol 10 (Nonilfenol 10) is a member of the class of phenols that is phenol which is para-substituted with a nonyl group. It has a role as an environmental contaminant.Nonylphenol 10 (Nonilfenol 10) (4-NP) is an estrogenic endocrine active chemical that is present in detergents and is known to contaminate food and drinking water. The predominant metabolite in bile was a glucuronide conjugate of Nonylphenol 10 (Nonilfenol 10). Other metabolites included glucuronide conjugates of ring or side chain hydroxylated Nonylphenol 10 (Nonilfenol 10).Liver contained a low level (1.7%) of covalently bound residues. Metabolism studies using isolated trout hepatocytes produced a similar range of metabolites and a sulfate conjugate of hydroxylated Nonylphenol 10 (Nonilfenol 10). Despite rapid metabolism and excretion, a substantial depot of parent compound remained in muscle which will have implications for the maintenance of Nonylphenol 10 (Nonilfenol 10) residues and associated biological activity.Nonylphenol 10 (Nonilfenol 10) (4-NP) is a well-known toxic environmental contaminant. The major objective of the present study was to identify reactive metabolites of 4-NP. Following incubations of 4-NP with NADPH- and GSH-supplemented human liver microsomes, 6 GSH conjugates, along with 19 oxidized metabolites, were detected by UPLC/Q-TOF mass spectrometry utilizing the mass defect filter method.Nonylphenol 10 (Nonilfenol 10) has known human metabolites that include (4-Nonylphenyl) hydrogen sulfate.Nonylphenol 10 (Nonilfenol 10) is a thick, yellow liquid. It is very slightly to insoluble in water. USE: Nonylphenol 10 (Nonilfenol 10) is used to make lubricating oil additives, resins, plasticizers, fungicides, rubbers and plastics. These products are used in industry, agriculture and in the home. Household products containing Nonylphenol 10 (Nonilfenol 10) include food packaging and rubber items intended for repeated use in contact with food . Nonylphenol 10 (Nonilfenol 10) is a mixture component of nonylphenol which is present in many household maintenance products such as epoxy. Nonylphenols are being phased out of use in consumer products. EXPOSURE: Workers that use Nonylphenol 10 (Nonilfenol 10) may breathe in vapors or have direct skin contact. The general population may be exposed by ingestion of or dermal contact with contaminated water and dermal contact with products containing this compound. Nonylphenol 10 (Nonilfenol 10) has been detected in human breast milk, blood and urine. If Nonylphenol 10 (Nonilfenol 10) is released to the environment, it will be very persistent. It will be broken down in air but is not expected to be broken down by sunlight. It will move slowly into air from moist soil and water surfaces. It is not expected to move through soil. It will be broken down by microorganisms and is expected to build up in fish, animals and humans. RISK: Altered function has been observed in human immune cells exposed to Nonylphenol 10 (Nonilfenol 10) in a laboratory setting. These studies suggest that exposure to Nonylphenol 10 (Nonilfenol 10) may increase the risk of autoimmune diseases, where the body’s immune system attacks healthy cells, such as inflammatory bowel disease. However, there are no studies evaluating potential associations between Nonylphenol 10 (Nonilfenol 10) exposure levels in humans and immune function. No additional data on the potential toxic effects of Nonylphenol 10 (Nonilfenol 10) in humans were available. Severe eye damage was observed in laboratory animals following direct exposure. Increased immune responses to known allergens were observed in laboratory animals exposed to Nonylphenol 10 (Nonilfenol 10) via injection, indicating that Nonylphenol 10 (Nonilfenol 10) may aggravate allergic diseases. Data on the potential for Nonylphenol 10 (Nonilfenol 10) to cause infertility, abortion, or birth defects were not available. However, risk factors for obesity (increases in body weight, fat mass and serum cholesterol) were observed in both first and second generation offspring of laboratory animals exposed to oral doses of Nonylphenol 10 (Nonilfenol 10) during pregnancy only. Obesity risk factors were also observed in young laboratory animals directly exposed to Nonylphenol 10 (Nonilfenol 10) via injection. Data on the potential for Nonylphenol 10 (Nonilfenol 10) to cause cancer in laboratory animals were not available. The potential for Nonylphenol 10 (Nonilfenol 10) to cause cancer in humans has not been assessed by the U.S. EPA IRIS program, the International Agency for Research on Cancer, or the U.S. National Toxicology Program 14th Report on Carcinogens. (SRC)The two commercial purity grades of Nonylphenol 10 (Nonilfenol 10) are a technical grade which is composed of 10-12% 2-nonylphenol, 85-90% Nonylphenol 10 (Nonilfenol 10), and up to 5% 2,4-dinonylphenol, and a high purity grade which contains 5% maximum 2-nonylphenol, 95% minimum Nonylphenol 10 (Nonilfenol 10), and only a trace of 2,4-dinonylphenol.The pressurized liquid extraction (PLE) of Nonylphenol 10 (Nonilfenol 10) (4-NP) with methanol (100 degrees C and 100 atm) from river sediments was compared with methanolic Soxhlet extraction, the standard method for the sediment analysis. The PLE method showed a precision (average RSD ranged from 6 to 33%) and an accuracy (average recovery 85 and 87% for 4-NP and 4-NPE, respectively) comparable to those of Soxhlet. The extraction was performed on river sediments and no organic carbon content influence was found. The comparative study presented in this paper demonstrates that PLE is an alternative suitable extraction method for Nonylphenol 10 (Nonilfenol 10) and Nonylphenol 10 (Nonilfenol 10) ethoxylate determination in sediments.Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Nonylphenol 10 (Nonilfenol 10) is included on this list.The independent and combined effects of 2 chemicals, diazinon (an insecticide) and Nonylphenol 10 (Nonilfenol 10) (a detergent metabolite), on the swimming behavior of the freshwater crustacean Daphnia pulex were examined. Cumulative distance and change in direction were measured repeatedly via optical tracking over 90 min. Exposure to low concentrations of diazinon (0.125-2 uM) or Nonylphenol 10 (Nonilfenol 10) (0.25-4 uM) elicited significant concentration- and time-dependent effects on swimming behavior. Exposure to 0.5 uM Nonylphenol 10 (Nonilfenol 10) alone did not significantly alter mean cumulative distance but did elicit a small, significant increase in mean angle, the measure of change in direction. When 0.5 uM Nonylphenol 10 (Nonilfenol 10) was used in combination with diazinon (0.125-0.5 uM), it augmented the adverse impact of diazinon on the swimming behavior of Daphnia. Additionally, enhanced sensitivity to diazinon was observed in animals exposed to treated wastewater effluent for 24 hr prior to a diazinon challenge. The present experiments demonstrate that exposure to Nonylphenol 10 (Nonilfenol 10) and complex chemical mixtures (e.g., treated wastewater) can enhance the toxicity of exposure to the insecticide diazinon.Nonylphenol 10 (Nonilfenol 10) is a widely diffused and stable environmental contaminant, originating from the degradation of alkyl phenol ethoxylates, common surfactants employed in several industrial applications. Due to its hydrophobic nature, Nonylphenol 10 (Nonilfenol 10) can easily accumulate in living organisms, including humans, where it displays a wide range of toxic effects. Since the gastrointestinal tract represents the main route by which Nonylphenol 10 (Nonilfenol 10) enters the body, the intestine may be one of the first organs to be damaged by chronic exposure to this pollutant through the diet. In the present study, we investigated the effects of Nonylphenol 10 (Nonilfenol 10) on a human intestinal epithelial cell line (Caco-2 cells). We demonstrated that Nonylphenol 10 (Nonilfenol 10) was cytotoxic to cells, as revealed by a decrease of the cell number and the decrement of mitochondrial functionality after 24 hr of treatment. Nonylphenol 10 (Nonilfenol 10) also reduced the number of cells entering into S-phase and interfered with epidermal growth factor signaling, with consequent negative effects on cell survival. In addition, Nonylphenol 10 (Nonilfenol 10) induced apoptosis, involving the activation of caspase-3, and triggered an endoplasmic reticulum-stress response, as revealed by over-expression of GRP78 (78 kDa glucose-regulated protein) and activation of XBP1 (X-box binding protein-1). Together, these findings support the hypothesis that prolonged exposure to Nonylphenol 10 (Nonilfenol 10) through the diet may lead to local damage at the level of intestinal mucosa, with potentially negative consequences for intestinal homeostasis and functionality.Exogenous substances altering the function of the endocrine system and exhibiting adverse health effects on the organism are defined as endocrine disruptors. Nonylphenol is one of the most abundant alkylphenol ethoxylate derivatives, being detected in food products. Diverse studies have classified nonylphenol as hazardous to the health, especially to male reproduction. This in vitro study aimed to examine the effects of Nonylphenol 10 (Nonilfenol 10) on androstenedione and testosterone production as well as on the viability of Leydig cells of NMRI mice. The cells were cultured for 44 h with addition of 0.04; 0.2; 1.0; 2.5 and 5.0 ug/mL of Nonylphenol 10 (Nonilfenol 10) and compared to the control. Quantification of testosterone and androstenedione directly from aliquots of the medium was performed by enzyme-linked immunosorbent assay. Cell viability was measured by the metabolic activity assay for mitochondrial functional activity. Androstenedione production significantly (P < 0.001) increased with 1.0; 2.5 and 5.0 ug/mL Nonylphenol 10 (Nonilfenol 10). Although cAMP-stimulated testosterone production was not significantly affected by Nonylphenol 10 (Nonilfenol 10), a tendency to attenuate the level of testosterone in the Leydig cells treated with 2.5 and 5.0 ug/mL Nonylphenol 10 (Nonilfenol 10) was observed. The viability of mouse Leydig cells was slightly increased at the lowest doses of Nonylphenol 10 (Nonilfenol 10) (0.04 and 0.2 ug/mL). We also observed an increase at higher concentrations of the substance (1.0; 2.5 and 5.0 ug/mL), but this increase was not significant. Further investigations are required to establish the biological significance and possible reproductive implications.
TR
Nonylphenol 10 (Nonilfenol 10) IUPAC Ad 4-nonilfenol
Nonylphenol 10 (Nonilfenol 10) InChI 1S / C15H24O / c1-2-3-4-5-6-7-8-9-14-10-12-15 (16) 13-11-14 / h10-13,16H , 2-9H2,1H3
Nonylphenol 10 (Nonilfenol 10) InChI Anahtar IGFHQQFPSIBGKE-UHFFFAOYSA-N
Nonylphenol 10 (Nonilfenol 10) Kanonik SMILES CCCCCCCCCC1 = CC = C (C = C1) O
Nonylphenol 10 (Nonilfenol 10) Moleküler Formül C15H24O
Nonylphenol 10 (Nonilfenol 10) CAS 104-40-5
Nonylphenol 10 (Nonilfenol 10) Kullanmdan Kaldrlm CAS 29832-11-9
Nonylphenol 10 (Nonilfenol 10) Avrupa Topluluu (EC) Say 203-199-4
Nonylphenol 10 (Nonilfenol 10) DSSTox Madde Kimlii DTXSID0028375
Nonylphenol 10 (Nonilfenol 10) Fiziksel Tanm Kat
Nonylphenol 10 (Nonilfenol 10) Renk / Form Viskoz, sar sv
Nonylphenol 10 (Nonilfenol 10) Kaynama Noktas 317 ° C
Nonylphenol 10 (Nonilfenol 10) Erime Noktas 42.0 ° C
Nonylphenol 10 (Nonilfenol 10) Parlama Noktas 113 ° C (235 ° F) – kapal kap
Nonylphenol 10 (Nonilfenol 10) Çözünürlük 3.18e-05 M
Nonylphenol 10 (Nonilfenol 10) Younluk 20 ° C’de 0.950 g / cu cm
Nonylphenol 10 (Nonilfenol 10) Buhar Basnc 8.18e-04 mmHg
Nonylphenol 10 (Nonilfenol 10) LogP 5.76 (LogP)
Nonylphenol 10 (Nonilfenol 10) Ayrma Ayrmaya kadar stldnda keskin bir duman ve tahri edici buharlar yayar.
Nonylphenol 10 (Nonilfenol 10) Krlma ndeksi Krlma ndeksi: 20 ° C’de 1.513
Nonylphenol 10 (Nonilfenol 10) Moleküler Arlk 220.35 g / mol
Nonylphenol 10 (Nonilfenol 10) XLogP3 5,9
Nonylphenol 10 (Nonilfenol 10) Hidrojen Ba Donör Says 1
Nonylphenol 10 (Nonilfenol 10) Hidrojen Ba Alc Says 1
Nonylphenol 10 (Nonilfenol 10) Döndürülebilir Ba Says 8
Nonylphenol 10 (Nonilfenol 10) Tam Kütle 220.182715 g / mol
Nonylphenol 10 (Nonilfenol 10) Monoizotopik Kütle 220.182715 g / mol
Nonylphenol 10 (Nonilfenol 10) Topolojik Polar Yüzey Alan 20,2 Ų
Nonylphenol 10 (Nonilfenol 10) Ar Atom Says 16
Nonylphenol 10 (Nonilfenol 10) Resmi arj 0
Nonylphenol 10 (Nonilfenol 10) Karmakl 148
Nonylphenol 10 (Nonilfenol 10) zotop Atom Says 0
Nonylphenol 10 (Nonilfenol 10) Tanml Atom Stereocenter Says 0
Nonylphenol 10 (Nonilfenol 10) Tanmsz Atom Stereocenter Says 0
Nonylphenol 10 (Nonilfenol 10) Tanmlanm Bond Stereocenter Says 0
Nonylphenol 10 (Nonilfenol 10) Tanmsz Ba Stereocenter Says 0
Nonylphenol 10 (Nonilfenol 10) Kovalent Bal Birim Says 1
Nonylphenol 10 (Nonilfenol 10) Bileii Kanonikletirilmitir Evet
Nonylphenol 10 (Nonilfenol 10), bir nonil grubu ile para-ikame edilmi fenol olan fenol snfnn bir üyesidir. Çevresel kirletici olarak rol oynar. Nonylphenol 10 (Nonilfenol 10) (4-NP), deterjanlarda bulunan ve yiyecekleri ve içme suyunu kirlettii bilinen östrojenik bir endokrin aktif kimyasaldr. Safradaki baskn metabolit, Nonilfenol 6’nn (Nonilfenol 6) bir glukuronid konjugatdr. Dier metabolitler, halka veya yan zincir hidroksile Nonilfenol 6’nn (Nonilfenol 6) glukuronid konjugatlarn içerir. Karacier, düük seviyede (% 1.7) kovalent olarak balanm kalntlar içeriyordu. zole edilmi alabalk hepatositlerinin kullanld metabolizma çalmalar, benzer bir metabolit aral ve hidroksile Nonilfenol 6’nn (Nonilfenol 6) bir sülfat konjugat üretti. Hzl metabolizma ve boaltma ramen, kasta önemli miktarda ana bileik deposu kalmtr, bu da Nonylphenol 10 (Nonilfenol 10) kalntlarnn ve ilikili biyolojik aktivitenin sürdürülmesi için etkileri olacaktr. Nonylphenol 10 (Nonilfenol 10) (4-NP), bilinen toksik çevresel kirletici. Bu çalmann ana amac 4-NP’nin reaktif metabolitlerini belirlemekti. 4-NP’nin NADPH ve GSH takviyeli insan karacier mikrozomlar ile inkübasyonunu takiben, 6 GSH konjugat ve 19 oksitlenmi metabolit, kütle kusur filtresi yöntemi kullanlarak UPLC / Q-TOF kütle spektrometresi ile tespit edildi. Nonylphenol 10 (Nonilfenol 10) (4-Nonilfenil) hidrojen sülfat içeren bilinen insan metabolitlerine sahiptir. Nonylphenol 10 (Nonilfenol 10) kaln, sar bir svdr. Suda çok az çözünür. KULLANIM: Nonylphenol 10 (Nonilfenol 10) yalama ya katk maddeleri, reçineler, plastikletiriciler, fungisitler, kauçuklar ve plastikler yapmak için kullanlr. Bu ürünler sanayide, tarmda ve evde kullanlmaktadr. Nonylphenol 10 (Nonilfenol 10) içeren ev ürünleri, gda ambalaj ve gda ile temas halinde tekrar tekrar kullanlmas amaçlanan kauçuk öeleri içerir. Nonylphenol 10 (Nonilfenol 10) epoksi gibi birçok ev bakm ürününde bulunan nonilfenolün bir karm bileenidir. Nonilfenoller, tüketici ürünlerinde kullanmdan kaldrlyor. MARUZ KALMA: Nonylphenol 10 (Nonilfenol 10) kullanan içiler buharlar soluyabilir veya dorudan ciltle temas edebilir. Genel popülasyon, kontamine su yutulmas veya dermal temas yoluyla ve bu bileii içeren ürünlerle deri temas yoluyla maruz kalabilir. Nonylphenol 10 (Nonilfenol 10) anne sütü, kan ve idrarnda tespit edilmitir. Nonylphenol 10 (Nonilfenol 10) çevreye salnrsa çok kalc olacaktr. Havada parçalanacaktr, ancak güne nda parçalanmas beklenmemektedir. O whasta nemli toprak ve su yüzeylerinden yavaça havaya geçer. Toprakta hareket etmesi beklenmez. Mikroorganizmalar tarafndan parçalanacak ve balklarda, hayvanlarda ve insanlarda birikmesi bekleniyor. RSK: Laboratuvar ortamnda Nonilfenol 6’ya (Nonilfenol 6) maruz kalan insan baklk hücrelerinde deien fonksiyon gözlenmitir. Bu çalmalar, Nonilfenol 6’ya (Nonilfenol 6) maruz kalmann, vücudun baklk sisteminin iltihapl barsak hastal gibi salkl hücrelere saldrd otoimmün hastalk riskini artrabileceini düündürmektedir. Bununla birlikte, insanlarda Nonylphenol 10 (Nonilfenol 10) maruziyet seviyeleri ile baklk fonksiyonu arasndaki potansiyel ilikileri deerlendiren hiçbir çalma yoktur. Nonylphenol 6’nn (Nonilfenol 6) insanlarda potansiyel toksik etkilerine ilikin ek veri mevcut deildir. Dorudan maruziyetin ardndan laboratuar hayvanlarnda ciddi göz hasar gözlemlendi. Enjeksiyon yoluyla Nonilfenol 6’ya (Nonilfenol 6) maruz braklan laboratuvar hayvanlarnda bilinen alerjenlere kar artan baklk tepkileri gözlendi, bu da Nonilfenol 6’nn (Nonilfenol 6) alerjik hastalklar iddetlendirebileceini gösteriyor. Nonilfenol 6’nn (Nonilfenol 6) ksrla, düük veya doum kusurlarna neden olma potansiyeline ilikin veriler mevcut deildi. Bununla birlikte, yalnzca gebelik srasnda oral dozlarda Nonylphenol 10 (Nonilfenol 10) alan laboratuar hayvanlarnn hem birinci hem de ikinci nesil yavrularnda obezite için risk faktörleri (vücut arl, ya kütlesi ve serum kolesterolünde art) gözlenmitir. Enjeksiyon yoluyla dorudan Nonilfenol 6’ya (Nonilfenol 6) maruz kalan genç laboratuvar hayvanlarnda da obezite risk faktörleri gözlendi. Nonilfenol 6’nn (Nonilfenol 6) laboratuar hayvanlarnda kansere neden olma potansiyeline ilikin veriler mevcut deildi. Nonilfenol 6’nn (Nonilfenol 6) insanlarda kansere neden olma potansiyeli ABD EPA IRIS program, Uluslararas Kanser Aratrma Ajans veya ABD Ulusal Toksikoloji Program 14. Karsinojenler Raporu tarafndan deerlendirilmemitir. (SRC) Nonilfenol 6’nn (Nonilfenol 6) iki ticari saflk derecesi,% 10-12 2-nonilfenol,% 85-90 Nonylphenol 10 (Nonilfenol 10) ve% 5’e kadar 2,4’ten oluan bir teknik snftr. -dinonilfenol ve% 5 maksimum 2-nonilfenol,% 95 minimum Nonylphenol 10 (Nonilfenol 10) ve sadece 2,4-dinonilfenol içeren yüksek saflk derecesi. Nonilfenol 6’nn (Nonilfenol) basnçl sv ekstraksiyonu (PLE) 6) (4-NP) nehir çökeltilerinden metanol (100 derece C ve 100 atm) ile sediman analizi için standart yöntem olan metanolik Soxhlet ekstraksiyonu ile karlatrld. PLE yöntemi, Soxhlet’inkilerle karlatrlabilir bir hassasiyet (ortalama RSD% 6 ila 33 arasnda) ve bir doruluk (4-NP ve 4-NPE için srasyla% 85 ve% 87) gösterdi. Ekstraksiyon nehir çökeltileri üzerinde gerçekletirildi ve organik karbon içerii etkisi bulunmad. Bu yazda sunulan karlatrmal çalma, PLE’nin çökeltilerde Nonylphenol 10 (Nonilfenol 10) ve Nonylphenol 10 (Nonilfenol 10) etoksilat tayini için alternatif uygun bir ekstraksiyon yöntemi olduunu göstermektedir. TSCA bölüm 8 (d) uyarnca, EPA bir model Salk yaynlamtr. ve Güvenlik Verileri Raporlama Kural. Bölüm 8 (d) model kural, listelenen kimyasal maddeler ve karmlarn üreticilerinin, ithalatçlarnn ve ileyicilerinin EPA kopyalarn ve yaynlanmam salk ve güvenlik çalmalar listelerini sunmasn gerektirir. Nonylphenol 10 (Nonilfenol 10) bu listeye dahil edilmitir. 2 kimyasaln, diazinon (bir böcek ilac) ve Nonylphenol 10 (Nonilfenol 10) (bir deterjan metaboliti), tatl su kabuklu Daphnia pulex’in yüzme davran üzerindeki bamsz ve birleik etkileri incelendi. Kümülatif mesafe ve yöndeki deiiklik, 90 dakika boyunca optik izleme yoluyla tekrar tekrar ölçüldü. Düük konsantrasyonlarda diazinon (0.125-2 uM) veya Nonylphenol 10 (Nonilfenol 10) (0.25-4 uM) maruziyet yüzme davran üzerinde önemli konsantrasyon ve zamana bal etkiler ortaya çkarmtr. Tek bana 0.5 uM Nonilfenol 6’ya (Nonilfenol 6) maruz kalma, ortalama kümülatif mesafeyi önemli ölçüde deitirmedi, ancak yöndeki deiikliin ölçüsü olan ortalama açda küçük, önemli bir arta yol açt. 0.5 uM Nonylphenol 10 (Nonilfenol 10), diazinon (0.125-0.5 uM) ile kombinasyon halinde kullanldnda, diazinonun Daphnia’nn yüzme davran üzerindeki olumsuz etkisini artrd. Ek olarak, bir diazinon tehdidinden 24 saat önce artlm atk su çkna maruz kalan hayvanlarda diazinona kar artan hassasiyet gözlendi. Mevcut deneyler, Nonilfenol 6’ya (Nonilfenol 6) ve karmak kimyasal karmlara (örnein, artlm atk su) maruz kalmann, insektisit diazinona maruz kalmann toksisitesini artrabileceini göstermektedir. Nonylphenol 10 (Nonilfenol 10), yaygn olarak dalm ve stabil bir çevresel kirletici olup, alkil fenol etoksilatlarn bozunmasndan, çeitli endüstriyel uygulamalarda kullanlan yaygn yüzey aktif maddeler. Nonylphenol 10 (Nonilfenol 10) hidrofobik yaps nedeniyle, çok çeitli toksik etki gösterdii insanlar da dahil olmak üzere canl organizmalarda kolaylkla birikebilir.ts. Gastrointestinal sistem, Nonylphenol 6’nn (Nonilfenol 6) vücuda girdii ana yolu temsil ettiinden, barsak, diyet yoluyla bu kirleticiye kronik maruziyetten zarar görecek ilk organlardan biri olabilir. Bu çalmada, Nonilfenol 6’nn (Nonilfenol 6) insan barsak epitel hücre hatt (Caco-2 hücreleri) üzerindeki etkilerini aratrdk. Nonilfenol 6’nn (Nonilfenol 6), 24 saatlik tedaviden sonra hücre saysndaki azalma ve mitokondriyal ilevselliin azalmasyla ortaya çkt üzere hücreler için sitotoksik olduunu gösterdik. Nonylphenol 10 (Nonilfenol 10) ayrca S-fazna giren hücrelerin saysn azaltt ve epidermal büyüme faktörü sinyallemesine müdahale etti ve bunun sonucunda hücre sakalm üzerinde olumsuz etkileri oldu. Ek olarak, Nonylphenol 10 (Nonilfenol 10), kaspaz-3’ün aktivasyonunu içeren apoptozu indükledi ve GRP78’in ar ekspresyonu (78 kDa glikozla düzenlenmi protein) ve XBP1’in aktivasyonu ( X-box balayc protein-1). Birlikte, bu bulgular, diyet yoluyla Nonilfenol 6’ya (Nonilfenol 6) uzun süre maruz kalmann barsak mukozas düzeyinde yerel hasara yol açabilecei ve barsak homeostaz ve ilevsellii için potansiyel olarak olumsuz sonuçlara yol açabilecei hipotezini desteklemektedir. Endokrin fonksiyonunu deitiren dsal maddeler sistemi ve organizma üzerinde olumsuz salk etkileri sergileyen endokrin bozucular olarak tanmlanmaktadr. Nonilfenol, gda ürünlerinde tespit edilen en bol alkilfenol etoksilat türevlerinden biridir. Çeitli çalmalar nonilfenolü sala, özellikle erkek üremesine zararl olarak snflandrmtr. Bu in vitro çalma, Nonilfenol 6’nn (Nonilfenol 6) androstenedion ve testosteron üretimi üzerindeki etkilerinin yan sra NMRI farelerinin Leydig hücrelerinin canll üzerindeki etkilerini incelemeyi amaçlad. Hücreler, 0.04 ilavesiyle 44 saat kültürlendi; 0.2; 1.0; 2.5 ve 5.0 ug / mL Nonylphenol 10 (Nonilfenol 10) ve kontrol ile karlatrld. Testosteron ve androstenedionun dorudan ortamn alikotlarndan kantifikasyonu, enzime bal immünosorbent analizi ile gerçekletirildi. Hücre canll, mitokondriyal fonksiyonel aktivite için metabolik aktivite analizi ile ölçüldü. Androstenedion üretimi önemli ölçüde (P <0.001) 1.0 ile artt; 2.5 ve 5.0 ug / mL Nonylphenol 10 (Nonilfenol 10). CAMP ile uyarlan testosteron üretimi, Nonilfenol 6’dan (Nonilfenol 6) önemli ölçüde etkilenmemi olsa da, 2.5 ve 5.0 ug / mL Nonylphenol 10 (Nonilfenol 10) ile tedavi edilen Leydig hücrelerinde testosteron düzeyini zayflatma eilimi gözlenmitir. Fare Leydig hücrelerinin yaayabilirlii, Nonilfenol 6’nn (Nonilfenol 6) (0.04 ve 0.2 ug / mL) en düük dozlarnda hafifçe artmtr. Ayrca maddenin daha yüksek konsantrasyonlarnda (1.0; 2.5 ve 5.0 ug / mL) bir art gözlemledik, ancak bu art önemli deildi. Biyolojik önemi ve olas üremeyle ilgili sonuçlar belirlemek için daha fazla aratrma yaplmas gerekmektedir.