PCMC
PCMC
CAS No. : 59-50-7
EC No. : 200-431-6
Synonyms:
4-Chloro-3-methylphenol; Chlorocresol; 59-50-7; 4-Chloro-m-cresol; p-Chloro-m-cresol; p-Chlorocresol; Phenol, 4-chloro-3-methyl-; Parol; Ottafact; Baktol; 4-Chloro-3-cresol; Candaseptic; Baktolan; Parmetol; Peritonan; Raschit; Aptal; Rasen-Anicon; 4-Chloro-5-methylphenol; PCMC; Preventol CMK; Raschit K; p-Chlor-m-cresol; 2-Chloro-5-hydroxytoluene; 6-Chloro-3-hydroxytoluene; 3-METHYL-4-CHLOROPHENOL; 2-Chloro-hydroxytoluene; Chlorcresolum; Chlorkresolum; Chlorocresolo; Chlorokresolum; Perol; m-Cresol, 4-chloro-; Chloro-3-cresol; Parachlorometacresol; Rcra waste number U039; 4-Chloro-3-methyl phenol; NSC 4166; 4-chloro-meta-cresol; Clorocresolo [DCIT]; Clorocresol [Spanish]; Caswell No. 185A; Chlorocresolum [Latin]; para-Chloro-meta-cresol; Clorocresol [INN-Spanish]; Chlorocresolum [INN-Latin]; CCRIS 1938; HSDB 5198; UNII-36W53O7109; 4-Chloro-1-hydroxy-3-methylbenzene; EINECS 200-431-6; RCRA waste no. U039; EPA Pesticide Chemical Code 064206; BRN 1237629; AI3-00075; CHEBI:34395; 1-Chloro-2-methyl-4-hydroxybenzene; MFCD00002323; NCGC00091338-01; 36W53O7109; DSSTox_CID_1717; DSSTox_RID_76291; DSSTox_GSID_21717; Chlorocresolum; Clorocresol; Clorocresolo; 4-Chloro-3-methylphenol, 99+%; CAS-59-50-7; 4-chloro-3-methyl-phenol; Chlorocresol [USAN:INN]; Lysochlor; Chlorocresol [USAN:INN:NF]; Chlorocresol, NF; Spectrum_000130; 2p7a; 4-chlor-3-methylphenol; Chlorocresol (NF/INN); Spectrum2_000002; Spectrum4_000278; Spectrum5_000705; 4-chloro-5-methyl-phenol; WLN: QR DG C; EC 200-431-6; SCHEMBL12344; KBioGR_000776; KBioSS_000590; KSC490K6D; MLS002152924; BIDD:ER0169; DivK1c_000768; Phenol, 4-chloro-5-methyl-; SPECTRUM1500178; SPBio_000003; ZINC1124; CHEMBL1230222; DTXSID4021717; 4-Chloro-3-methylphenol, 99%; CTK3J0561; HMS502G10; KBio1_000768; KBio2_000590; KBio2_003158; KBio2_005726; EBD9810; NSC4166; NINDS_000768; HMS1920O03; HMS2091C14; HMS3652F13; HMS3885P09; Pharmakon1600-01500178; HY-B1284; KS-00000WI3; NSC-4166; Tox21_111116; Tox21_201293; Tox21_300054; ANW-33283; CCG-39979; HSCI1_000352; LS-252; NSC756680; s4209; SBB060654; STL268900; AKOS000120242; Tox21_111116_1; CS-4678; MCULE-7719563630; NE10170; NSC-756680; Chlorocresol (4-Chloro-3-methylphenol); IDI1_000768; NCGC00091338-02; NCGC00091338-03; NCGC00091338-04; NCGC00091338-06; NCGC00254021-01; NCGC00258845-01; 4-Chloro-3-methylphenol, technical grade; AC-14332; Q208; SC-16335; SMR001224524; SBI-0051308.P003; 4-Chloro-3-methylphenol, analytical standard; B1696; FT-0618220; ST50823834; SW219289-1; AZ0001-0105; 4-Chloro-3-methylphenol, >=98.0% (HPLC); A16444; C14331; D03468; AB00051939_02; AB00051939_03; Q302865; SR-05000002033; 4-Chloro-3-methylphenol 100 microg/mL in Methanol; Q-200453; SR-05000002033-1; BRD-K89056082-001-03-6; F0001-1543; Z955123738; 43M; 6-Chloro-3-hydroxytoluene; 2-Chloro-5-hydroxytoluene; 3-Methyl-4-chlorophenol; p-Chloro-m-cresol; 4-Chloro-m-cresol
EN
PCMC IUPAC Name 4-chloro-3-methylphenol
PCMC InChI 1S/C7H7ClO/c1-5-4-6(9)2-3-7(5)8/h2-4,9H,1H3
PCMC InChI Key CFKMVGJGLGKFKI-UHFFFAOYSA-N
PCMC Canonical SMILES CC1=C(C=CC(=C1)O)Cl
PCMC Molecular Formula C7H7ClO
PCMC CAS 59-50-7
PCMC Related CAS 15733-22-9 (hydrochloride salt)
PCMC European Community (EC) Number 200-431-6
PCMC ICSC Number 0131
PCMC NSC Number 756680
PCMC RTECS Number GO7100000
PCMC UN Number 2669
PCMC UNII 36W53O7109
PCMC DSSTox Substance ID DTXSID4021717
PCMC Physical Description WHITE OR SLIGHTLY PINK HYGROSCOPIC CRYSTALS OR CRYSTALLINE POWDER.
PCMC Color/Form Dimorphous crystals … aqueous solutions turn yellow on exposure to light and air
PCMC Odor Said to be odorless when very pure, but usually a phenolic odor persists
PCMC Boiling Point 455 °F at 760 mm Hg
PCMC Melting Point 151 °F
PCMC Flash Point 230 °F
PCMC Solubility less than 1 mg/mL at 68° F
PCMC Density 0.9 at 77 °F
PCMC Vapor Pressure 0.05 mmHg
PCMC LogP 3.1 (LogP)
PCMC Stability/Shelf Life Aq solns turn yellow on exposure to light and air.
PCMC Autoignition Temperature 590 °C
PCMC Decomposition When heated to decomposition it emits toxic fumes of phosgene /and hydrogen chloride/.
PCMC pH pH = 5.6 in saturated aqueous solution
PCMC Odor Threshold detection: 0.1 mg/kg
PCMC Dissociation Constants pKa = 9.55
PCMC Molecular Weight 142.58 g/mol
PCMC XLogP3 3.1
PCMC Hydrogen Bond Donor Count 1
PCMC Hydrogen Bond Acceptor Count 1
PCMC Rotatable Bond Count 0
PCMC Exact Mass 142.018542 g/mol
PCMC Monoisotopic Mass 142.018542 g/mol
PCMC Topological Polar Surface Area 20.2 Ų
PCMC Heavy Atom Count 9
PCMC Formal Charge 0
PCMC Complexity 94.9
PCMC Isotope Atom Count 0
PCMC Defined Atom Stereocenter Count 0
PCMC Undefined Atom Stereocenter Count 0
PCMC Defined Bond Stereocenter Count 0
PCMC Undefined Bond Stereocenter Count 0
PCMC Covalently-Bonded Unit Count 1
PCMC Compound Is Canonicalized Yes
PCMC appears as a pinkish to white crystalline solid with a phenolic odor. Melting point 64-66°C. Shipped as a solid or in a liquid carrier. Soluble in aqueous base. Toxic by ingestion, inhalation or skin absorption. Used as an external germicide. Used as a preservative in paints and inks.PCMC appears as a pinkish to white crystalline solid with a phenolic odor. Melting point 64-66°C. Shipped as a solid or in a liquid carrier. Soluble in aqueous base. Toxic by ingestion, inhalation or skin absorption. Used as an external germicide. Used as a preservative in paints and inks.PCMC and chloracetamide are used in medications, glues, and cosmetics as preservatives.At all concentrations of /4-chloro-m-cresol/ (4-cmc), the increase in baseline force was significantly greater in the /malignant hyperthermia susceptible/ (MHS) group compared to the /malignant hyperthermia negative/ MHN group (P<0.05). Muscle from 15 MHS patients responded to 4-cmc with increasing force at a threshold concentration of 75 umol/L or less, whereas muscle from 23 MH-non-susceptible (MHN) patients had thresholds of 100 umol/L or more. The accuracy of the PCMC test was thus 100% (95% confidence limits 90.75-100%) at a threshold of 75 umol/L. Amplitude of contractures at 2 mmol/L caffeine was not different from contractures at 75 umol/L of 4-cmc in either the MHS or the MHN group (P>0.05). In vivo concentrations of PCMC from clinical use of insulin and somatropin are estimated to be 20 times less than the threshold concentration and thus these drugs seem safe in MH patients. 4-chloro-m-cresol may be a suitable aid to clarify puzzling results of standard testing of MH susceptibility.In skeletal muscle sarcoplasmic reticulum, 4-chloro-m-cresol was found to be a potent activator of Ca2+ release mediated by a ruthenium red/caffeine-sensitive Ca2+ release channel. In cerebellar microsomes, this compound released Ca2+ from an inositol-1,4,5-trisphosphate-insensitive store, suggesting that there too it was acting at the ryanodine receptor level. When tested on PC12 cells, PCMC released Ca2+ from a caffeine- and thapsigargin-sensitive intracellular store. In addition, the compound was capable of releasing Ca2+ after pretreatment of PC12 cells with bradykinin, suggesting that it acts on a channel contained within an intracellular Ca2+ store that is distinct from that sensitive to inositol-1,4,5-trisphosphate. Structure-activity relationship analyses suggest that the chloro and methyl groups in PCMCs are important for the activation of the ryanodine receptor Ca2+ release channel.PCMCS are incompatible with bases, acid chlorides, acid anhydrides, and oxidizing agents. Corrodes steel, brass, copper and copper alloys (NTP, 1992).TOXIC (COMBUSTIBLE)/ Health: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /PCMCs; PCMCs, liquid; PCMCs, solid; PCMCs, solution/GUIDE 152: SUBSTANCES – TOXIC (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. /PCMCs; PCMCs, liquid; PCMCs, solid; PCMCs, solution/GUIDE 152: SUBSTANCES – TOXIC (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number … As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. /PCMCs; PCMCs, liquid; PCMCs, solid; PCMCs, solution/SUBSTANCES – TOXIC (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters’ protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /PCMCs; PCMCs, liquid; PCMCs, solid; PCMCs, solution/To examine the effect on the leakage of low molecular weight cytoplasmic constituents from Staphylococcus aureus using phenolics singly and in combination, and to see if the observations could be modelled using a non-linear dose response. The rate of potassium, phosphate and adenosine triphosphate leakage was examined in the presence of PCMC and m-cresol. Individually, leakage was observed only at long contact times or high concentrations. Combined at these ineffective concentrations, the cytoplasmic pool of all constituents studied was released within minutes. Both PCMC and m-cresol were shown to have non-linear dose responses. A rate model for the combinations, which takes account of these non-linear responses, accurately predicted the observations. Antimicrobials, which when used alone exhibit a non-linear dose response, will also give a non-linear dose response in combination. The simple linear-additive model ignores the concept of the dilution coefficient and will always describe the phenomenon of synergy for combinations where one or more of the components has a dilution coefficient greater than one. This has been borne out by examination of the purported prime lesion of PCMC and m-cresol, alone and in combination. Studies aimed at producing synergistic mixtures of antimicrobials, which ignore the non-linear additive effect, may waste valuable research effort looking for a physiological explanation for an apparent synergy, where none, in-fact, exists. Patents granted on the basis of analyses using the linear-additive model for combinations of compounds with non-linear dose responses may no longer be supportable.4-Chloro-m-cresol/ is a preservative within a large number of commercially available preparations (e.g. insulin, hormones, etc.). Regarding the results of contracture testing with 4-CmC it has been suggested that 4-CmC possibly represents a high-risk agent for /malignant hyperthermia susceptible/ individuals. To reduce the risk of /malignant hyperthermia/ in susceptible patients due to administration of PCMCs, …/avoid/ preparations containing the preservative 4-CmC.The biocide PCMC (CMP, CAS number 59-50-7) is a common additive to metal-working fluids (MWF) and building materials. … In the current study, the in vitro human epidermal permeability of CMP contained in a working dilution of TRIM VX (20% in water) was evaluated and, for comparison, permeability from an aqueous buffer was also assessed. CMP penetration was also measured from transient exposures to 20% TRIM VX. … Transient (20 or 40 min) exposures of epidermal membranes to 20% TRIM VX (/sample size/ = 4) resulted in total penetration of 4.2 +/- 1.2 and 7.3 +/- 0.8 ug/sq cm, respectively.PCMC is the organic compound with the formula ClC6H4OH. It is a monochlorinated m-cresol. It is a white or colorless solid that is only slightly soluble in water. As a solution in alcohol and in combination with other phenols, it is used as an antiseptic and preservative.[1][2] It is a moderate allergen for sensitive skin.This assessment report has been established as a result of the evaluation of the active substance PCMC (also referred to as p-chloro-m-cresol or CMK) as product-type 3 (Veterinary Hygiene), carried out in the context of the work programme for the review of existing active substances provided for in Article 89 of Regulation (EU) No 528/2012, with a view to the possible approval of this substance.PCMC (CAS no. 59-50-7) was notified as an existing active substance, by LANXESS Deutschland GmbH hereafter referred to as the applicant, in product-type 3. In the text of this report, when p-chloro-m-cresol is mentioned, it refers to the active substance PCMC.Most neurotoxins produce either diffuse encephalopathy or peripheral neuropathy. Only ethylene glycol, trichlorethylene, and PCMC exposure cause selective cranial nerve toxicity. Ethylene glycol is antifreeze. Ingestion causes facial diplegia, hearing impairment, and dysphagia. Trichlorethylene intoxication can cause multiple cranial neuropathies but has a predilection for the trigeminal nerve. It was once a treatment for tic douloureux. PCMC, a compound used in the industrial production of heparin, caused recurrent unilateral facial palsy in one exposed worker. Inhalation of the compound caused tingling of one side of the face followed by weakness of the muscles. The neurological disturbance was brief, relieved by exposure to fresh air, and could be reproduced experimentally.SSG (Pentostam, GlaxoSmithKline) is available in a 100-mL amber glass bottle sealed with a synthetic butyl rubber stopper and aluminum collar. There are 100 mg of SbV per mL. Pentostam also contains PCMC BP, glucono-delta-lactone HSE, and sterile water for injection.
TR
PCMC IUPAC Ad 4-kloro-3-metilfenol
PCMC InChI 1S / C7H7ClO / c1-5-4-6 (9) 2-3-7 (5) 8 / h2-4,9H, 1H3
PCMC InChI Anahtar CFKMVGJGLGKFKI-UHFFFAOYSA-N
PCMC Kanonik SMILES CC1 = C (C = CC (= C1) O) Cl
PCMC Moleküler Formül C7H7ClO
PCMC CAS 59-50-7
PCMC ile lgili CAS 15733-22-9 (hidroklorür tuzu)
PCMC Avrupa Topluluu (EC) Numaras 200-431-6
PCMC ICSC Numaras 0131
PCMC NSC Numaras 756680
PCMC RTECS Numaras GO7100000
PCMC UN Numaras 2669
PCMC UNII 36W53O7109
PCMC DSSTox Madde Kimlii DTXSID4021717
PCMC Fiziksel Tanm BEYAZ VEYA YUMUAK PEMBE HGROSKOPK KRSTALLER VEYA KRSTAL GB TOZ.
PCMC Renk / Form Dimorföz kristaller … sulu çözeltiler, a ve havaya maruz kaldklarnda sararr
PCMC Kokusu Çok saf olduunda kokusuz olduu söylenir, ancak genellikle fenolik bir koku devam eder
PCMC Kaynama Noktas 760 mm Hg’de 455 ° F
PCMC Erime Noktas 151 ° F
PCMC Parlama Noktas 230 ° F
68 ° F’de PCMC Çözünürlüü 1 mg / mL’den az
77 ° F’de PCMC Younluu 0.9
PCMC Buhar Basnc 0.05 mmHg
PCMC LogP 3.1 (LogP)
PCMC Stabilite / Raf Ömrü Aq çözücüler, a ve havaya maruz kaldnda sarya döner.
PCMC Kendiliinden Tutuma Scakl 590 ° C
PCMC Ayrmas Ayrmaya kadar stldnda zehirli fosgen / ve hidrojen klorür / dumanlar yayar.
PCMC pH pH = 5,6 doymu sulu çözelti içinde
PCMC Koku Eii alglama: 0,1 mg / kg
PCMC Ayrlma Sabitleri pKa = 9.55
PCMC Moleküler Arlk 142,58 g / mol
PCMC XLogP3 3.1
PCMC Hidrojen Ba Donör Says 1
PCMC Hidrojen Ba Alcs Says 1
PCMC Döndürülebilir Tahvil Says 0
PCMC Tam Kütle 142.018542 g / mol
PCMC Monoizotopik Kütle 142.018542 g / mol
PCMC Topolojik Polar Yüzey Alan 20,2 Ų
PCMC Ar Atom Says 9
PCMC Resmi Ücreti 0
PCMC Karmakl 94.9
PCMC zotop Atom Says 0
PCMC Tanml Atom Stereocenter Says 0
PCMC Tanmsz Atom Stereo Merkez Saym 0
PCMC Tanml Bond Stereocenter Says 0
PCMC Tanmsz Ba Stereocenter Says 0
PCMC Kovalent Bal Birim Says 1
PCMC Bileii Kanonikletirilmitir Evet
PCMC, fenolik bir kokuya sahip pembemsi ila beyaz kristalli bir kat olarak görünür. Erime noktas 64-66 ° C. Kat veya sv tayc içinde sevk edilir. Sulu bazda çözünür. Yutulmas, solunmas veya cilt tarafndan emilmesi halinde toksiktir. Harici bir mikrop öldürücü olarak kullanlr. Boya ve mürekkeplerde koruyucu olarak kullanlr. PCMC, fenolik bir kokuya sahip pembemsi beyaz kristalli bir kat olarak görünür. Erime noktas 64-66 ° C. Kat veya sv tayc içinde sevk edilir. Sulu bazda çözünür. Yutulmas, solunmas veya cilt tarafndan emilmesi halinde toksiktir. Harici bir mikrop öldürücü olarak kullanlr. Boya ve mürekkeplerde koruyucu olarak kullanlr. PCMC ve klorasetamid, ilaçlarda, yaptrclarda ve kozmetiklerde koruyucu olarak kullanlr. / 4-kloro-m-kresol / (4-cmc) ‘nin tüm konsantrasyonlarnda, temel kuvvetteki art önemli ölçüde artmtr. / malign hipertermi duyarl / (MHS) grubunda / malign hipertermi negatif / MHN grubuna kyasla daha yüksek (P <0.05). 15 MHS hastasndan alnan kas, 75 umol / L veya daha düük bir eik konsantrasyonda artan kuvvetle 4 cmc’ye yant verirken, 23 MH-duyarl olmayan (MHN) hastadan alnan kas, 100 umol / L veya daha fazla eiklere sahipti. PCMC testinin doruluu bu nedenle 75 umol / L’lik bir eikte% 100’dür (% 95 güven snrlar% 90,75-100). 2 mmol / L kafeinde kontraktürlerin amplitüdü, MHS veya MHN grubunda 75 umol / L 4 cmc’deki kontraktürlerden farkl deildi (P> 0.05). nsülin ve somatropinin klinik kullanmndan kaynaklanan in vivo PCMC konsantrasyonlarnn, eik konsantrasyondan 20 kat daha az olduu tahmin edilmektedir ve bu nedenle bu ilaçlar, MH hastalarnda güvenli görünmektedir. 4-kloro-m-kresol, standart MH duyarll testinin artc sonuçlarn açkla kavuturmak için uygun bir yardmc olabilir. skelet kas sarkoplazmik retikulumunda, 4-kloro-m-kresolün, rutenyumun araclk ettii güçlü bir Ca2 + salnm aktivatörü olduu bulunmutur. krmz / kafeine duyarl Ca2 + salm kanal. Serebellar mikrozomlarda, bu bileik Ca2 + ‘y bir inositol-1,4,5-trisfosfata duyarsz depodan salm ve orada da ryanodin reseptörü seviyesinde hareket ettiini düündürmütür. PC12 hücreleri üzerinde test edildiinde, PCMC kafein ve thapsigargin duyarl hücre içi depodan Ca2 + sald. Ek olarak, bileik, PC12 hücrelerinin bradikinin ile ön ilemden geçirilmesinden sonra Ca2 + salabilme kabiliyetine sahipti, bu da inositol-1,4,5-trisfosfata duyarl olandan farkl bir hücre içi Ca2 + deposu içinde bulunan bir kanal üzerinde hareket ettiini düündürdü. Yap-aktivite ilikisi analizleri, PCMC’lerdeki kloro ve metil gruplarnn ryanodin reseptörü Ca2 + salm kanalnn aktivasyonu için önemli olduunu göstermektedir. PCMCS, bazlar, asit klorürler, asit anhidritler ve oksitleyici maddelerle uyumsuzdur. Çelik, pirinç, bakr ve bakr alamlarn andrr (NTP, 1992). TOKSK (YANABLR) / Salk: Solunmas, yutulmas veya deri yoluyla emilmesi halinde çok toksiktir. Erimi maddeyle temas, ciltte ve gözlerde ciddi yanklara neden olabilir. Herhangi bir cilt temasndan kaçnn. Temas veya inhalasyon etkileri gecikebilir. Yangn tahri edici, andrc ve / veya toksik gazlar üretebilir. Yangn kontrolünden veya seyreltme suyundan aknt,andrc ve / veya toksik olabilir ve kirlilie neden olabilir. / PCMC’ler; PCMC’ler, sv; PCMC’ler, kat; PCMC’ler, çözüm / KILAVUZ 152: MADDELER – ZEHRL (YANICI) / Yangn veya Patlama: Yanabilir malzeme: yanabilir ancak hemen tutumaz. Kaplar stldnda patlayabilir. Yüzey ak su yollarn kirletebilir. Madde erimi formda tanabilir. / PCMC’ler; PCMC’ler, sv; PCMC’ler, kat; PCMC’ler, çözüm / KILAVUZ 152: MADDELER – ZEHRL (YANABLR) / Kamu Güvenlii: Acil bir önlem olarak Acil Müdahale Telefon Numaras … Svlar için en az 50 metre (150 fit) boyunca her yönde dökülme veya sznt alann izole edin ve katlar için en az 25 metre (75 fit). Yetkisiz personeli uzak tutun. Rüzgara kar kaln. Alçak alanlardan uzak durun. / PCMC’ler; PCMC’ler, sv; PCMC’ler, kat; PCMC’ler, çözelti / MADDELER – ZEHRL (YANICI) / Koruyucu Giysi: Pozitif basnçl bamsz solunum cihaz (SCBA) kullann. Üretici tarafndan özel olarak önerilen kimyasal koruyucu giysiler giyin. Çok az termal koruma salayabilir veya hiç salamayabilir. Yapsal itfaiyecilerin koruyucu kyafetleri YALNIZCA yangn durumlarnda snrl koruma salar; Madde ile dorudan temasn mümkün olduu dökülme durumlarnda etkili deildir. / PCMC’ler; PCMC’ler, sv; PCMC’ler, kat; PCMC’ler, çözüm / Tek bana ve kombinasyon halinde fenolikler kullanarak Staphylococcus aureus’tan düük moleküler arlkl sitoplazmik bileenlerin sznts üzerindeki etkisini incelemek ve gözlemlerin dorusal olmayan bir doz yant kullanlarak modellenip modellenemeyeceini görmek için. Potasyum, fosfat ve adenozin trifosfat sznts oran PCMC ve m-kresol varlnda incelendi. Bireysel olarak, sznt yalnzca uzun temas sürelerinde veya yüksek konsantrasyonlarda gözlendi. Bu etkisiz konsantrasyonlarda birletirildiinde, incelenen tüm bileenlerin sitoplazmik havuzu dakikalar içinde serbest brakld. Hem PCMC hem de m-kresolün dorusal olmayan doz tepkilerine sahip olduu gösterilmitir. Bu dorusal olmayan tepkileri hesaba katan kombinasyonlar için bir hz modeli, gözlemleri doru bir ekilde tahmin etti. Tek bana kullanldklarnda dorusal olmayan bir doz tepkisi sergileyen antimikrobiyaller, kombinasyon halinde dorusal olmayan bir doz tepkisi de verecektir. Basit dorusal katk modeli, seyreltme katsays kavramn göz ard eder ve bir veya daha fazla bileenin birden büyük bir seyreltme katsaysna sahip olduu kombinasyonlar için her zaman sinerji olgusunu açklayacaktr. Bu, PCMC ve m-kresolün sözde ana lezyonunun tek bana ve kombinasyon halinde incelenmesi ile dorulanmtr. Dorusal olmayan katk etkisini göz ard eden sinerjik antimikrobiyal karmlar üretmeyi amaçlayan çalmalar, aslnda hiçbirinin bulunmad, görünür bir sinerji için fizyolojik bir açklama aramak için deerli aratrma çabalarn boa harcayabilir. Dorusal olmayan doz tepkileri olan bileiklerin kombinasyonlar için dorusal katk modeli kullanan analizler temelinde verilen patentler artk desteklenemeyebilir. 4-Kloro-m-kresol / ticari olarak temin edilebilen çok sayda preparat içinde bir koruyucudur (örn. insülin, hormonlar vb.). 4-CmC ile kontraktür testinin sonuçlarna ilikin olarak, 4-CmC’nin muhtemelen / malign hipertermiye duyarl / bireyler için yüksek riskli bir ajan temsil ettii öne sürülmütür. PCMC’lerin uygulanmasna bal duyarl hastalarda / malign hipertermi / riskini azaltmak için, … / koruyucu 4-CmC içeren preparatlardan kaçnn. Biyosit PCMC (CMP, CAS numaras 59-50-7) yaygn bir katk maddesidir. metal ileme svlarna (MWF) ve yap malzemelerine. … Bu çalmada, TRIM VX’in (suda% 20) bir çalma seyreltisinde bulunan CMP’nin in vitro insan epidermal geçirgenlii deerlendirildi ve karlatrma için sulu bir tampondan geçirgenlik de deerlendirildi. CMP penetrasyonu ayrca geçici maruziyetlerden% 20 TRIM VX’e kadar ölçüldü. … Epidermal membranlarn% 20 TRIM VX’e (/ numune boyutu / = 4) geçici (20 veya 40 dakika) maruz kalmalar, srasyla 4,2 +/- 1,2 ve 7,3 +/- 0,8 ug / sq cm toplam penetrasyon ile sonuçlanmtr. PCMC, ClC6H4OH formülüne sahip organik bileiktir. Monoklorlu bir m-kresoldür. Suda çok az çözünür olan beyaz veya renksiz bir katdr. Alkolde çözelti olarak ve dier fenollerle kombinasyon halinde antiseptik ve koruyucu olarak kullanlr. [1] [2] Hassas ciltler için orta derecede bir alerjendir. Bu deerlendirme raporu, aktif madde PCMC’nin (p-kloro-m-kresol veya CMK olarak da adlandrlr) ürün tipi 3 (Veteriner Hijyen) olarak deerlendirilmesi sonucu oluturulmutur. , 528/2012 sayl Tüzüün (AB) 89. Maddesinde öngörülen mevcut aktif maddelerin gözden geçirilmesine yönelik çalma program balamnda, bu maddenin olas onay göz önünde bulundurularak yürütülür. PCMC (CAS no. 59- 50-7), ürün tipi 3’te LANXESS Deutschland GmbH tarafndan bundan sonra bavuru sahibi olarak anlacak olan mevcut bir aktif madde olarak bildirilmitir. Bu raporun metninde, p-chloro-m-kresol’den bahsedildiinde, aktif madde PCMC. çou nörotoksinler, yaygn ensefalopati veya periferal nöropati üretir. Yalnzca etilen glikol, trikloroetilen ve PCMC’ye maruz kalma, seçici kraniyal sinir toksisitesine neden olur. Etilen glikol antifrizdir. Yutma, yüz disfajisine, iitme bozukluuna ve disfajiye neden olur. Trikloroetilen zehirlenmesi birden fazla kraniyal nöropatiye neden olabilir, ancak trigeminal sinir için bir tercihe sahiptir. Bir zamanlar tic douloureux için bir tedaviydi. Heparinin endüstriyel üretiminde kullanlan bir bileik olan PCMC, maruz kalan bir içide tekrarlayan tek tarafl yüz felcine neden oldu. Bileiin solunmas yüzün bir tarafnda karncalanmaya ve ardndan kaslarn zayflamasna neden oldu. Nörolojik rahatszlk ksa sürdü, temiz havaya maruz braklarak rahatlad ve deneysel olarak yeniden üretilebilirdi.SSG (Pentostam, GlaxoSmithKline), sentetik bir bütil kauçuk tpa ve alüminyum yaka ile kapatlm 100 mL’lik amber cam iede mevcuttur. ML bana 100 mg SbV vardr. Pentostam ayrca PCMC BP, glukono-delta-lakton HSE ve enjeksiyon için steril su içerir.