PEG 200 (POLYETHYLENE GLYCOL 200)
PEG 200
Cas No: 25322-68-3
synonyms:
Polyethylene glycol 200; PEG; poly(oxyethylene); polyglycol; polyether glycol; PEG 200; PEG 200; polyethyleneglycol; POLYETHYLENE GLYCOL; Dispersant PEG 200; polyethylene oxide (PEO); polyoxyethylene (POE); Oxyethylene polymer; PEG (polyglycol); PEG 200; Polyglycol 200; POLYGLYCOL 200; POLGLKOL 200; poliglikol 200; polietilen glikol 200; POLETLEN GLKOL 200; oksietilen polimeri; polioksietilen; PEG 120 Methyl Glucose Dioleate; PEG 1500; PEG 2000; PEG 300; PEG 200; PEG 3000 OLEATE; PEG 40 HYDROGENATED CASTOR OIL; PEG 200; PEG 400 OLEATE; Dispersant PEG 200; PEG 4000 POLYETHYLENE GLYCOL 4000; PEG 600; PEG 6000; POLYETHER; polyether; 1,2-ethanediol homopolymer; PEG 2000; α,ω-hydroxypoly(ethylene oxide); α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl); α-hydro-ω-hydroxypoly(oxyethylene); ethylene glycol homopolymer; ethylene glycol polymer; Glycols; Dispersant PEG 200; polyethylene; PEG 200; Glycol 200; Dispersant PEG 200; polyethylene 200; Macrogol; PEG; POE; poly(ethyleneoxide); poly(oxyethylene); Polyäthylenglykol; polyethylene glycols; polyoxyethylene; polyoxyethylene 200; peg 200; polietilen glikol 200; polyetilen glikol 200; Peg; peg 1500; polietilenglikol; PEG 200; polietilen glikol; peg 6000; peg 600; poly ( ethylene glycol ); Cas No: 25322-68-3; PEG 200; macrogol; carbowax polyethylene glycol (PEG); Alkyl polyethyleneglycol ether; Polyethylene oxide; poly glycol; poli glikol; poli etilen oksit; poli etilen glikol; polietilenglikol; polyethyleneglycol; poly ethylene glycol; poly ethyleneglycol; PEG 200; poli etilenglikol; poli; etilen; glikol; poly; ethylene; glycol; PEG; PEG 200; peg 200; polietilen glikol 200; polyethyleneglycol 200; polyethylene glycol 200; polyethylene, glycol, 200; polietilen; glikol; 200; PEG 2000; polyethylene glycol monostearate; POLYETHYLENE GLYCOL MONOSTEARATE; PEG 200; Dispersant PEG 200; Water Based Coatings Dispertants; Dispersiyon PEG 200; dispersiyon peg 200; DSPERSYON PEG 200; PEG 2000; Polyethylene glycol 200; PEG; poly(oxyethylene); polyglycol; polyether glycol; PEG200; PEG 200; polyethyleneglycol; PEG 2000; POLYETHYLENE GLYCOL; polyethylene oxide (PEO); polyoxyethylene (POE); Oxyethylene polymer; PEG (polyglycol); Polyglycol 200; POLYGLYCOL 200; POLGLKOL 200; poliglikol 200; polietilen glikol 200; POLETLEN GLKOL 200; oksietilen polimeri; polioksietilen; PEG 120 Methyl Glucose Dioleate; PEG 1500; PEG 2000; PEG 300; PEG 3000 OLEATE; PEG 40 HYDROGENATED CASTOR OIL; PEG 400 OLEATE; Dispersant PEG 200; PEG 4000; PEG 200; POLYETHYLENE GLYCOL 4000; PEG 600; PEG 6000; POLYETHER; polyether; 1,2-ethanediol homopolymer; PEG 200; PEG 2000; α,ω-hydroxypoly(ethylene oxide); PEG 200; α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl); α-hydro-ω-hydroxypoly(oxyethylene); ethylene glycol homopolymer; ethylene glycol polymer; Polyethylene glycol 200; PEG; poly(oxyethylene); polyglycol; polyether glycol; PEG200; PEG 200; polyethyleneglycol; POLYETHYLENE GLYCOL; PEG 2000; Dispersant PEG 200; polyethylene oxide (PEO); polyoxyethylene (POE); Oxyethylene polymer; PEG (polyglycol); Polyglycol 200; POLYGLYCOL 200; POLGLKOL 200; poliglikol 200; polietilen glikol 200; POLETLEN GLKOL 200; oksietilen polimeri; polioksietilen; PEG 120 Methyl Glucose Dioleate; PEG 1500; PEG 2000; PEG 300; PEG 3000 OLEATE; PEG 2000; PEG 40 HYDROGENATED CASTOR OIL; PEG 400 OLEATE; Dispersant PEG 200; PEG 4000 POLYETHYLENE GLYCOL 4000; PEG 600; PEG 6000; POLYETHER; polyether; 1,2-ethanediol homopolymer; Glycols; Dispersant PEG 200; polyethylene; Glycol 200; Dispersant PEG 200; polyethylene 200; Macrogol; PEG; POE; poly(ethyleneoxide); poly(oxyethylene); Polyäthylenglykol; polyethylene glycols; polyoxyethylene; polyoxyethylene 200; peg 200; polietilen glikol 200; polyetilen glikol 200; Peg; peg 1500; polietilenglikol; polietilen glikol; peg 6000; peg 600; poly ( ethylene glycol ); Cas No: 25322-68-3; macrogol; carbowax polyethylene glycol (PEG); Alkyl polyethyleneglycol ether; coating peg 200; COATING PEG 200. Polyethylene glycol 200; PEG; poly(oxyethylene); polyglycol; polyether glycol; PEG 200; PEG 200; polyethyleneglycol; POLYETHYLENE GLYCOL; Dispersant PEG 200; polyethylene oxide (PEO); polyoxyethylene (POE); Oxyethylene polymer; PEG (polyglycol); PEG 200; Polyglycol 200; POLYGLYCOL 200; POLGLKOL 200; poliglikol 200; polietilen glikol 200; POLETLEN GLKOL 200; oksietilen polimeri; polioksietilen; PEG 120 Methyl Glucose Dioleate; PEG 1500; PEG 2000; PEG 300; PEG 200; PEG 3000 OLEATE; PEG 40 HYDROGENATED CASTOR OIL; PEG 200; PEG 400 OLEATE; Dispersant PEG 200; PEG 4000 POLYETHYLENE GLYCOL 4000; PEG 600; PEG 6000; POLYETHER; polyether; 1,2-ethanediol homopolymer; PEG 2000; α,ω-hydroxypoly(ethylene oxide); α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl); α-hydro-ω-hydroxypoly(oxyethylene); ethylene glycol homopolymer; ethylene glycol polymer; Glycols; Dispersant PEG 200; polyethylene; PEG 200; Glycol 200; Dispersant PEG 200; polyethylene 200; Macrogol; PEG; POE; poly(ethyleneoxide); poly(oxyethylene); Polyäthylenglykol; polyethylene glycols; polyoxyethylene; polyoxyethylene 200; peg 200; polietilen glikol 200; polyetilen glikol 200; Peg; peg 1500; polietilenglikol; PEG 200; polietilen glikol; peg 6000; peg 600; poly ( ethylene glycol ); Cas No: 25322-68-3; PEG 200; macrogol; carbowax polyethylene glycol (PEG); Alkyl polyethyleneglycol ether; Polyethylene oxide; poly glycol; poli glikol; poli etilen oksit; poli etilen glikol; polietilenglikol; polyethyleneglycol; poly ethylene glycol; poly ethyleneglycol; PEG 200; poli etilenglikol; poli; etilen; glikol; poly; ethylene; glycol; PEG; PEG 200; peg 200; polietilen glikol 200; polyethyleneglycol 200; polyethylene glycol 200; polyethylene, glycol, 200; polietilen; glikol; 200; PEG 2000; polyethylene glycol monostearate; POLYETHYLENE GLYCOL MONOSTEARATE; PEG 200; Dispersant PEG 200; Water Based Coatings Dispertants; Dispersiyon PEG 200; dispersiyon peg 200; DSPERSYON PEG 200; PEG 2000; Polyethylene glycol 200; PEG; poly(oxyethylene); polyglycol; polyether glycol; PEG200; PEG 200; polyethyleneglycol; PEG 2000; POLYETHYLENE GLYCOL; polyethylene oxide (PEO); polyoxyethylene (POE); Oxyethylene polymer; PEG (polyglycol); Polyglycol 200; POLYGLYCOL 200; POLGLKOL 200; poliglikol 200; polietilen glikol 200; POLETLEN GLKOL 200; oksietilen polimeri; polioksietilen; PEG 120 Methyl Glucose Dioleate; PEG 1500; PEG 2000; PEG 300; PEG 3000 OLEATE; PEG 40 HYDROGENATED CASTOR OIL; PEG 400 OLEATE; Dispersant PEG 200;PEG-4, PEG-6, PEG-7, PEG-8, PEG-9, PEG-10, PEG-12, PEG-14, PEG-16, PEG-18, PEG-20, PEG-32, PEF-33, PEG-40, PEG-45, PEG-55, PEG-60, PEG-75, PEG-80, PEG-90, PEG-100, PEG-135, PEG-150, PEG-180, PEG 200, PEG-220, PEG-240, PEG-350, PEG-400, PEG-500, PEG-800, PEG-2M, PEG-5M, PEG-7M, PEG-9M, PEG-14M, PEG-20M, PEG-23M, PEG-25M, PEG-45M, PEG-65M, PEG-90M, PEG-115M, PEG-160M, PEG-180M; Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-, (200 mol EO average molar ratio); peg 200; Peg 200; PEG 200; Polietilen glikol 200; Polietilen glikol; Poli etilen glikol 200; Poli etilen glikol; pg200; PEG-200; Peg-200; peg-200; peg200
Polyethylene glycol 200 (PEG 200)
Description
Catalogue Number of PEG 200 807483
Synonyms of PEG 200 Polyglycol, Polyethylene oxide, Polyoxy ethylene, PEG 200,Polyethylene glycol
Product Information of PEG 200
CAS number of PEG 200 25322-68-3
EC number of PEG 200 500-038-2
Hill Formula of PEG 200 HO(C₂H₄O)nH
Chemical formula of PEG 200 HO(C₂H₄O)nH
Molar Mass of PEG 200 190 – 210 g/mol
HS Code of PEG 2003907 20 11
Quality Level of PEG 200 MQ200
Applications of PEG 200
Application of PEG 200 Polyethylene glycol 200 for synthesis. CAS No. 25322-68-3, EC Number 500-038-2.
Physicochemical Information
Boiling point of PEG 200 >150 °C
Density of PEG 200 1.124 g/cm3 (20 °C)
Flash point of PEG 200 180 °C
Ignition temperature of PEG 200 350 °C DIN 51794
Melting Point of PEG 200 -50 °C
pH value of PEG 200 5 – 7 (100 g/l, H₂O, 20 °C)
Vapor pressure of PEG 200 <0.01 hPa (20 °C)
Solubility of PEG 200 70 g/l soluble
Toxicological Information of PEG 200
LD 50 oral of PEG 200 LD50 Rat 28000 mg/kg
LD 50 dermal of PEG 200 LD50 Rabbit > 20000 mg/kg
Safety Information according to GHS
RTECS TQ3600000
Storage class 10 – 13 Other liquids and solids
WGK WGK 1 slightly hazardous to water
Disposal 3
Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
Storage and Shipping Information
Storage Storage temperature: no restrictions.
Transport Information
Good
Specifications
Density of PEG 200 (d 20 °C/ 4 °C) 1.124 – 1.126
Hydroxyl value of PEG 200 535 – 590
Average molecular mass of PEG 200 190 – 210
Identity (IR) of PEG 200 passes test
PEG 200
PEG 200 is classified as :
Humectant
Solvent
CAS Number 25322-68-3
COSING REF No: 78058
Chem/IUPAC Name: Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-, (200 mol EO average molar ratio)
What Is It?
Triethylene Glycol and other polyethylene glycols (PEG-4, PEG-6, PEG-7, PEG-8, PEG-9, PEG-10, PEG-12, PEG-14, PEG-16, PEG-18, PEG-20, PEG-32, PEF-33, PEG-40, PEG-45, PEG-55, PEG-60, PEG-75, PEG-80, PEG-90, PEG-100, PEG-135, PEG-150, PEG-180, PEG 200, PEG-220, PEG-240, PEG-350, PEG-400, PEG-500, PEG-800, PEG-2M, PEG-5M, PEG-7M, PEG-9M, PEG-14M, PEG-20M, PEG-23M, PEG-25M, PEG-45M, PEG-65M, PEG-90M, PEG-115M, PEG-160M, PEG-180M) are polymers of ethylene glycol. The number in the name represents the average number of ethylene glycol units. The letter “M†associated with the number stands for 1000, so PEG-25M is has an average of 25,000 units of ethylene glycol. The polyethylene glycol polymers are used in a wide variety of products including bath products, shaving products, skin care products, makeup, skin cleansing products, shampoo, hair conditioners and deodorants.
Why is it used in cosmetics and personal care products?
The following functions have been reported for these ingredients.
Anticaking agent – PEG-800
Binder – PEG-32, PEG-33, PEG-40, PEG-45, PEG-55, PEG-60, PEG-75, PEG-80, PEG-90, PEG-100, PEG-135, PEG-150, PEG-180, PEG 200, PEG-220, PEG-240, PEG-350, PEG-400, PEG-450, PEG-500, PEG-800, PEG-2M, PEG-5M, PEG-7M, PEG-9M, PEG-14M, PEG-20M, PEG-23M, PEG-25M, PEG-45M, PEG-65M, PEG-90M, PEG-115M, PEG-160M, PEG-180M
Emulsion stabilizer – PEG-350, PEG-400, PEG-450, PEG-500, PEG-2M, PEG-5M, PEG-7M, PEG-9M, PEG-14M, PEG-20M, PEG-23M, PEG-25M, PEG-45M, PEG-65M, PEG-90M, PEG-115M, PEG-160M, PEG-180M
Humectant – PEG-4, PEG-6, PEG-7, PEG-8, PEG-9, PEG-10, PEG-12, PEG-14, PEG-16, PEG-18, PEG-20, PEG-32, PEG-33, PEG-40, PEG-45, PEG-55, PEG-60, PEG-75, PEG-80, PEG-90, PEG-100, PEG-135, PEG-150, PEG-180, PEG 200, PEG-220, PEG-240, PEG-800
Plasticizer – PEG-800
Solvent – PEG-4, PEG-6, PEG-7, PEG-8, PEG-9, PEG-10, PEG-12, PEG-14, PEG-16, PEG-18, PEG-20, PEG-32, PEG-33, PEG-40, PEG-45, PEG-55, PEG-60, PEG-75, PEG-80, PEG-90, PEG-100, PEG-135, PEG-150, PEG-180, PEG 200, PEG-220, PEG-240, PEG-350, PEG-400, PEG-450, PEG-500
Viscosity decreasing agent – Triethylene Glycol
Viscosity increasing agent – aqueous – PEG-800, PEG-2M, PEG-5M, PEG-7M, PEG-9M, PEG-14M, PEG-20M, PEG-23M, PEG-25M, PEG-45M, PEG-65M, PEG-90M, PEG-115M, PEG-160M, PEG-180M
Scientific Facts:
Polyethylene Glycols are polymers of ethylene glycol. In addition to being named based on the number of units of ethylene glycol, they may also be named based on the molecular weight of the compound. For example, PEG-8 is also known as Polyethylene Glycol 400, where 400 represents the average molecular weight of the compound.
Peg 200
Polyethylene glycol 200 (Peg 200) is a defoaming agent, lubricant and viscosity modifier and used as a solvent in metal working fluids. In soaps and detergents, Peg 200 has applications as a viscosity modifier and solvent and in textiles Peg 200 is used as a lubricant, softener, dye carrier, dispersant and anti-static agent.
PEG 200 (Polyethylene Glycol 200) is a clear, colorless liquid that is made from sugar cane waste so PEG 200 is naturally derived and renewable. PEG 200 is completely soluble in water and has an average molecular weight of 190 – 210. PEGS are another group of products with an incredibly long list of uses and applications from industrial uses to food and pharma, and everything in between.
Polyethylene Glycol (PEG) 200
CAS: 25322-68-3
PEG 200 (Polyethylene Glycol 200) is a colorless, non-volatile, hygroscopic liquid. PEG 200 is soluble in water, acetone, alcohol, benzene, and glycols.
PEG 200 has many applications in various industries such as resins, agriculture, detergents, cosmetics and personal care, wood working, heat transfer fluids, lubricants, release agents, papers, plastics, adhesives, and textiles. PEG 200 is also commonly used to make emulsifying agents.
Abstract
Polyethylene glycols, particularly those with low molecular weights, are considered to be relatively non-toxic. Polyethylene glycol (PEG 200) was administered orally to Cynomolgus monkeys (Macaca fascicularis) and rats (Sprague-Dawley origin) for a 13-week period at dosage levels of 2 to 4 ml/kg (monkeys) and 2.5 to 5.0 ml/kg/day (rats). Pathological lesions were encountered only in monkeys and these consisted of intratubular deposition of small numbers of oxalate crystals in the renal cortex. These lesions were not associated with other clinical or pathological findings.
Polyethylene glycol
Not to be confused with Ethylene glycol or Diethylene glycol.
For medical uses of polyethylene glycol, see Macrogol.
Polyethylene glycol
PEG Structural Formula V1.svg
Names
IUPAC names
poly(oxyethylene) {structure-based},
poly(ethylene oxide) {source-based}[1]
Other names
Carbowax, GoLYTELY, GlycoLax, Fortrans, TriLyte, Colyte, Halflytely, macrogol, MiraLAX, MoviPrep
Identifiers
CAS Number
25322-68-3 ☑
ChEMBL
ChEMBL1201478 ☒
ChemSpider
none
ECHA InfoCard 100.105.546
E number E1521 (additional chemicals)
UNII
3WJQ0SDW1A ☒
CompTox Dashboard (EPA)
DTXSID4027862 Edit this at Wikidata
Properties
Chemical formula
C2nH4n+2On+1
Molar mass 44.05n + 18.02 g/mol
Density 1.125[2]
Pharmacology
ATC code
A06AD15 (WHO)
Hazards
Flash point 182-287 °C; 360-549 °F; 455-560 K
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Polyethylene glycol (PEG; /ˌpɒliˈɛθəlˌiːn ˈɡlaɪˌkɒl, -ˌkɔːl/) is a polyether compound with many applications, from industrial manufacturing to medicine. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight. The structure of PEG is commonly expressed as H-(O-CH2-CH2)n-OH.
Uses
Medical uses
Main article: Macrogol
PEG is the basis of a number of laxatives.[3] Whole bowel irrigation with polyethylene glycol and added electrolytes is used for bowel preparation before surgery or colonoscopy.
PEG is also used as an excipient in many pharmaceutical products.
When attached to various protein medications, polyethylene glycol allows a slowed clearance of the carried protein from the blood.[4]
The possibility that PEG could be used to fuse axons is being explored by researchers studying peripheral nerve and spinal cord injury.[3]
Chemical uses
The remains of the 16th century carrack Mary Rose undergoing conservation treatment with PEG in the 1980s
Terra cotta warrior, showing traces of original color
Because PEG is a hydrophilic molecule, it has been used to passivate microscope glass slides for avoiding non-specific sticking of proteins in single-molecule fluorescence studies.[5]
Polyethylene glycol has a low toxicity and is used in a variety of products.[6] The polymer is used as a lubricating coating for various surfaces in aqueous and non-aqueous environments.[7]
Since PEG is a flexible, water-soluble polymer, it can be used to create very high osmotic pressures (on the order of tens of atmospheres). It also is unlikely to have specific interactions with biological chemicals. These properties make PEG one of the most useful molecules for applying osmotic pressure in biochemistry and biomembranes experiments, in particular when using the osmotic stress technique.
Polyethylene glycol is also commonly used as a polar stationary phase for gas chromatography, as well as a heat transfer fluid in electronic testers.
PEG has also been used to preserve objects that have been salvaged from underwater, as was the case with the warship Vasa in Stockholm,[8] and similar cases. It replaces water in wooden objects, making the wood dimensionally stable and preventing warping or shrinking of the wood when it dries.[3] In addition, PEG is used when working with green wood as a stabilizer, and to prevent shrinkage.[9]
PEG has been used to preserve the painted colors on Terracotta Warriors unearthed at a UNESCO World Heritage site in China.[10] These painted artifacts were created during the Qin Shi Huang Di dynasty (first emperor of China). Within 15 seconds of the terra-cotta pieces being unearthed during excavations, the lacquer beneath the paint begins to curl after being exposed to the dry Xian air. The paint would subsequently flake off in about four minutes. The German Bavarian State Conservation Office developed a PEG preservative that when immediately applied to unearthed artifacts has aided in preserving the colors painted on the pieces of clay soldiers.[11]
PEG is often used (as an internal calibration compound) in mass spectrometry experiments, with its characteristic fragmentation pattern allowing accurate and reproducible tuning.
PEG derivatives, such as narrow range ethoxylates, are used as surfactants.
PEG has been used as the hydrophilic block of amphiphilic block copolymers used to create some polymersomes.[12]
PEG has also been used as a propellent on the UGM-133M Trident II Missile, in service with the United States Air Force.[13]
Biological uses
PEG is commonly used as a crowding agent in in vitro assays to mimic highly crowded cellular conditions.[5]
PEG is commonly used as a precipitant for plasmid DNA isolation and protein crystallization. X-ray diffraction of protein crystals can reveal the atomic structure of the proteins.
PEG is used to fuse two different types of cells, most often B-cells and myelomas in order to create hybridomas. César Milstein and Georges J. F. Köhler originated this technique, which they used for antibody production, winning a Nobel Prize in Physiology or Medicine in 1984.[3]
Polymer segments derived from PEG polyols impart flexibility to polyurethanes for applications such as elastomeric fibers (spandex) and foam cushions.
In microbiology, PEG precipitation is used to concentrate viruses. PEG is also used to induce complete fusion (mixing of both inner and outer leaflets) in liposomes reconstituted in vitro.
Gene therapy vectors (such as viruses) can be PEG-coated to shield them from inactivation by the immune system and to de-target them from organs where they may build up and have a toxic effect.[14] The size of the PEG polymer has been shown to be important, with larger polymers achieving the best immune protection.
PEG is a component of stable nucleic acid lipid particles (SNALPs) used to package siRNA for use in vivo.[15][16]
In blood banking, PEG is used as a potentiator to enhance detection of antigens and antibodies.[3][17]
When working with phenol in a laboratory situation, PEG 300 can be used on phenol skin burns to deactivate any residual phenol (some references are required).
In biophysics, polyethylene glycols are the molecules of choice for the functioning ion channels diameter studies, because in aqueous solutions they have a spherical shape and can block ion channel conductance.[18][19]
Commercial uses
PEG is the basis of many skin creams (as cetomacrogol) and personal lubricants (frequently combined with glycerin).
PEG is used in a number of toothpastes[3] as a dispersant. In this application, it binds water and helps keep xanthan gum uniformly distributed throughout the toothpaste.
PEG is also under investigation for use in body armor, and in tattoos to monitor diabetes.[20][21]
In low-molecular-weight formulations (e.g. PEG 400), it is used in Hewlett-Packard designjet printers as an ink solvent and lubricant for the print heads.
PEG is also used as an anti-foaming agent in food and drinks[22] – its INS number is 1521[23] or E1521 in the EU.[24]
Industrial uses
A nitrate ester-plasticized polyethylene glycol (NEPE-75) is used in Trident II submarine-launched ballistic missile solid rocket fuel.[25]
Dimethyl ethers of PEG are the key ingredient of Selexol, a solvent used by coal-burning, integrated gasification combined cycle (IGCC) power plants to remove carbon dioxide and hydrogen sulfide from the gas waste stream.
PEG has been used as the gate insulator in an electric double-layer transistor to induce superconductivity in an insulator.[26]
PEG is also used as a polymer host for solid polymer electrolytes. Although not yet in commercial production, many groups around the globe are engaged in research on solid polymer electrolytes involving PEG, with the aim of improving their properties, and in permitting their use in batteries, electro-chromic display systems, and other products in the future.
PEG is injected into industrial processes to reduce foaming in separation equipment.
PEG is used as a binder in the preparation of technical ceramics.[27]
Recreational uses
PEG is used to extend the size and durability of very large soap bubbles.
PEG is the main ingredient in many personal lubricants.
Health effects
PEG is generally considered biologically inert and safe. However, studies of clinical safety are generally based on adults, not children. The FDA has been asked to investigate the possible effects of PEG in laxatives for children.[28]
A minority of people are allergic to it. Allergy to PEG is usually discovered after a person has been diagnosed with an allergy to an increasing number of seemingly unrelated products, including processed foods, cosmetics, drugs, and other substances that contain PEG or were manufactured with PEG.[29]
When PEG is chemically attached to therapeutic molecules (such as protein drugs or nanoparticles), it can sometimes be antigenic, stimulating an anti-PEG antibody response in some patients. This effect has only been shown for a few of the many available PEGylated therapeutics, but it has significant effects on clinical outcomes of affected patients.[30] Other than these few instances where patients have anti-PEG immune responses, it is generally considered to be a safe component of drug formulations.
Available forms and nomenclature
PEG, PEO, and POE refer to an oligomer or polymer of ethylene oxide. The three names are chemically synonymous, but historically PEG is preferred in the biomedical field, whereas PEO is more prevalent in the field of polymer chemistry. Because different applications require different polymer chain lengths, PEG has tended to refer to oligomers and polymers with a molecular mass below 20,000 g/mol, PEO to polymers with a molecular mass above 20,000 g/mol, and POE to a polymer of any molecular mass.[31] PEGs are prepared by polymerization of ethylene oxide and are commercially available over a wide range of molecular weights from 300 g/mol to 10,000,000 g/mol.[32]
PEG and PEO are liquids or low-melting solids, depending on their molecular weights. While PEG and PEO with different molecular weights find use in different applications, and have different physical properties (e.g. viscosity) due to chain length effects, their chemical properties are nearly identical. Different forms of PEG are also available, depending on the initiator used for the polymerization process – the most common initiator is a monofunctional methyl ether PEG, or methoxypoly(ethylene glycol), abbreviated mPEG. Lower-molecular-weight PEGs are also available as purer oligomers, referred to as monodisperse, uniform, or discrete. Very high purity PEG has recently been shown to be crystalline, allowing determination of a crystal structure by x-ray diffraction.[32] Since purification and separation of pure oligomers is difficult, the price for this type of quality is often 10-1000 fold that of polydisperse PEG.
PEGs are also available with different geometries.
Branched PEGs have three to ten PEG chains emanating from a central core group.
Star PEGs have 10 to 100 PEG chains emanating from a central core group.
Comb PEGs have multiple PEG chains normally grafted onto a polymer backbone.
The numbers that are often included in the names of PEGs indicate their average molecular weights (e.g. a PEG with n = 9 would have an average molecular weight of approximately 400 daltons, and would be labeled PEG 400.) Most PEGs include molecules with a distribution of molecular weights (i.e. they are polydisperse). The size distribution can be characterized statistically by its weight average molecular weight (Mw) and its number average molecular weight (Mn), the ratio of which is called the polydispersity index (Mw/Mn). Mw and Mn can be measured by mass spectrometry.
PEGylation is the act of covalently coupling a PEG structure to another larger molecule, for example, a therapeutic protein, which is then referred to as a PEGylated protein. PEGylated interferon alfa-2a or -2b are commonly used injectable treatments for hepatitis C infection.
PEG is soluble in water, methanol, ethanol, acetonitrile, benzene, and dichloromethane, and is insoluble in diethyl ether and hexane. It is coupled to hydrophobic molecules to produce non-ionic surfactants.[33]
PEGs potentially contain toxic impurities, such as ethylene oxide and 1,4-dioxane.[34] Ethylene Glycol and its ethers are nephrotoxic if applied to damaged skin.[35]
Polyethylene oxide (PEO, Mw 4 kDa) nanometric crystallites (4 nm)
Polyethylene glycol (PEG) and related polymers (PEG phospholipid constructs) are often sonicated when used in biomedical applications. However, as reported by Murali et al., PEG is very sensitive to sonolytic degradation and PEG degradation products can be toxic to mammalian cells. It is, thus, imperative to assess potential PEG degradation to ensure that the final material does not contain undocumented contaminants that can introduce artifacts into experimental results.[36]
PEGs and methoxypolyethylene glycols are manufactured by Dow Chemical under the tradename Carbowax for industrial use, and Carbowax Sentry for food and pharmaceutical use. They vary in consistency from liquid to solid, depending on the molecular weight, as indicated by a number following the name. They are used commercially in numerous applications, including as surfactants, in foods, in cosmetics, in pharmaceutics, in biomedicine, as dispersing agents, as solvents, in ointments, in suppository bases, as tablet excipients, and as laxatives. Some specific groups are lauromacrogols, nonoxynols, octoxynols, and poloxamers.
Macrogol, used as a laxative, is a form of polyethylene glycol. The name may be followed by a number which represents the average molecular weight (e.g. macrogol 3350, macrogol 4000 or macrogol 6000).
Production
Polyethylene glycol 400, pharmaceutical quality
Polyethylene glycol 4000, pharmaceutical quality
The production of polyethylene glycol was first reported in 1859. Both A. V. Lourenço and Charles Adolphe Wurtz independently isolated products that were polyethylene glycols.[37] Polyethylene glycol is produced by the interaction of ethylene oxide with water, ethylene glycol, or ethylene glycol oligomers.[38] The reaction is catalyzed by acidic or basic catalysts. Ethylene glycol and its oligomers are preferable as a starting material instead of water, because they allow the creation of polymers with a low polydispersity (narrow molecular weight distribution). Polymer chain length depends on the ratio of reactants.
HOCH2CH2OH + n(CH2CH2O) → HO(CH2CH2O)n+1H
Depending on the catalyst type, the mechanism of polymerization can be cationic or anionic. The anionic mechanism is preferable because it allows one to obtain PEG with a low polydispersity. Polymerization of ethylene oxide is an exothermic process. Overheating or contaminating ethylene oxide with catalysts such as alkalis or metal oxides can lead to runaway polymerization, which can end in an explosion after a few hours.
Polyethylene oxide, or high-molecular weight polyethylene glycol, is synthesized by suspension polymerization. It is necessary to hold the growing polymer chain in solution in the course of the polycondensation process. The reaction is catalyzed by magnesium-, aluminium-, or calcium-organoelement compounds. To prevent coagulation of polymer chains from solution, chelating additives such as dimethylglyoxime are used.
Alkaline catalysts such as sodium hydroxide (NaOH), potassium hydroxide (KOH), or sodium carbonate (Na2CO3) are used to prepare low-molecular-weight polyethylene glycol.
PEG 200
PEG (200)
PEG 200 Cas No 25322-68-3
PEG 200 EINECS No 500-038-2
PEG 200 Chemical Formula (C2H4O) nH2O
PEG 200 Appearance Liquid
PEG 200 Purity (%) 99
PEG 200 Density (Kg / Liter) 1.1238
PEG 200 Flash Point, ° C150
PEG 200 Boiling Point, ° C –
PEG 200 Properties
PEG 200 is colorless, odorless and viscous liquid. It is miscible and soluble with water, many alcohols and organic solvents.
MOL WT. 190 – 210
APPEARANCE clear liquid
MOISTURE 0.2% max
HYDROXYL VALUE 535 – 590 (mg KOH/g)
pH 5 – 7
SPECIFIC GRAVITY 1.12 – 1.13
VISCOSITY 50 cP at 25 C
Polyethylene glycol is obtained in the presence of ethylene oxide and water in the polymerization of mono ethylene glycol or diethylene glycol. Polyethylene glycol, shortened to PEG, is also referred to as polyoxyethylene or poly ethylene oxide. Water soluble and non-toxic synthetic polyether.
Typical Known Applications for Polyethylene Glycols (PEG 200, PEG 300 ,PEG 400 ..)
Adhesives
Chemical Intermediates
Food Packaging
Inks
Lubricants
Mold Release Agent
Plasticizer
PRODUCT DETAILS & INFORMATION ABOUT PEG 20
Polyethylene glycol 200 (PEG 200) is a clear, colorless liquid at room temperature. Polyethylene glycol 200 (PEG-200, polyethylene glycol monostearate) is a polyether compound with the chemical structure H-(O-CH2-CH2)n-OH. PEG 200 raditionally, it is derived from petroleum-based sources. PEG-200 has a wide range of potential uses. It is a defoaming agent, lubricant and viscosity modifier in many different products. PEG-200 is also used as a coating for fresh fruit, as a solvent in metal working fluids, as a binder and modifier in latex paints, and as a humectant in inks and abrasives.
Specific industries that rely on PEG-200 include cosmetics, health and medicine, textiles and more. The viscosity of polyethylene glycol is 4.0-4.2 at 99 degrees C, cSt. PEG 200 has a maximum water content of 0.20 percent and a maximum acidity of 0.05 percent. Under normal conditions, PEG 200 is stable and nonreactive, but should be kept away from open flames, direct sunlight and strong oxidizers.Drums and Isotanks can use for packaging PEG 200.
Molecular weight range is from 200 to 6000 for PEG. Properties and fields of application vary according to molecular weight (Example, PEG200, PEG400 etc.) It is a clean, colorless, odorless and viscous liquid. PEG 200 is miscible and soluble with water, many alcohols and organic solvents. Many chemical vaccines are inferior. PEG 200 does not hydrolyze or decompose at low vapor pressures. Moisture trap, moisturizing and dispersing agent, petroleum based.
PEG 200,300,400 and 600 are used in the cleaning industry and detergents to dissolve surfactants in aqueous formulations. The PEG grades have high solvent strength and dispersing capacity for many pigments and dyes and are effective solvents for basic dyes and some dye bases. They are used in the office supply industry to formulate inks with high sealability. The density of the ink can be controlled using a mixture of solid and liquid PEG 200, PEG400, PEG600, varieties. PEG grades can be used as solvents for basic dyes in flexographic inks. Similarly, liquid and pulp pigment preparations can be used as pulp thickeners in textile, as solvents and dispersants in the paint and saramic industries. Polyethylene Glycol (when administered intravenously) has shown fatal heart attacks, central nervous system depression and skin burns. Polyethylene glycol (PEG) is a polyether compound with many applications from industrial manufacturing to medicine. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight as PEG 200 ,PEG 400 etc. The structure of PEG is commonly expressed as H-(O-CH2-CH2)n-OH.
PEG-200 has a wide range of potential uses. It is a defoaming agent, lubricant and viscosity modifier in many different products. PEG-200 is also used as a coating for fresh fruit, as a solvent in metal working fluids, as a binder and modifier in latex paints, and as a humectant in inks and abrasives.
PEG 200-300-400-600;
Used in mineral oil, textile, leather, metal and detergent industry as wax, paraffin and solvent emulsions, emulsifier, intermediate solvent, viscosity regulator, humidifier, alcohol component. Paint wood is used in cosmetic cleaning and leather industries.
PEG 200
PEG (200)
PEG 200 Cas No 25322-68-3
PEG 200 EINECS No 500-038-2
PEG 200 Kimyasal Formülü (C2H4O)nH2O
PEG 200 Görünüm Sv
PEG 200 Saflk(%) 99
PEG 200 Younluk (Kg/Litre) 1.1238
PEG 200 Parlama Noktas, °C150
PEG 200 Kaynama Noktas, °C –
PEG 200 Güvenlik Formu(Msds)
Polietilen glikol (PEG), etilen oksit ile suyun mono etilen glikolun veya dietilen glikolun polimerizasyonu neticesinde elde edilir. PEG olarak ksaltlan polietilen glikolun ayn zamanda poli oksietilen veya poli etilen oksit olarak adlandrmalar da mevcuttur. Suda çözünebilen ve zehirli olmayan sentetik polieterdir.
Polietilen glikol, sulu formülasyonlarda yüzey aktif karmlarn çözmek için temizleyici endüstrisinde ve deterjanlarda kullanlrlar. PEG çeitleri, yüksek solvent gücüne ve pigment ve boyalarn bir çoklar için datc kapasiteye sahiptir ve bazik boyalar ve baz boya bazlar için etkili çözücülerdir.Polietilen glikol (PEG) , tekstik sektöründe hamur koyulatrclar, boya ve seramik endüstrisinde çözücü ve datc ortam olarak kullanlabilirler.
Polietilen Glikol (PEG)(PEG 200-300-400-600-1000-1500-4000-6000-8000-12000-10000-18000-20000)
Fiziksel özellii : Sv
Kimyasal Formülü : HO(CH2CH2O)nH
Ambalaj ekli : Varil/IBC
Polimerizasyon derecesi olan n, her ürünün ortalama molar kütlesini ve gösterdii özellikleri belirler.
Kullanm Alanlar
-PEG 200-PEG 300-PEG 400-PEG 600 ; mineral ya,tekstil,deri,metal ve deterjan sanayilerinde wax, parafin ve çözgen emülsiyonlarnda emülgatör, ara çözücü,vizkozite ayarlayc,nemlendirici, ester üretiminde alkol komponenti olarak kullanlmaktadr.PEG 200 Boya aaç kozmetik temizlik ve deri sektörlerinde kullanlmaktadr.
-PEG 1000-PEG 1500- PEG 4000-PEG 6000-PEG 8000-PEG 9000-PEG 12000 çok çeitli sanayilerde emülgatör, yalayc ve kalp ayrc olarak kullanlmaktadr.
-Çözücü , datc olarak kullanlr.
-Viskozite ayarlayc olarak kullanlr.
-Kauçuk endüstrisinde kullanlr.
-Plastikletirici ,nem giderici ve emdirme ajan olarak kullanlmaktadr.
-Yalayc ve kalp ayrc olarak kullanlmaktadr.
-Kimyasal sentezlerde ara madde olarak kullanlmaktadr.
-Elektrolik kaplama ilemlerinde kullanlmaktadr.
-Kat deterjan konsantreleri mum boyalar sulu boyalarda kullanlr.
Nem tutucu, nemlendirme ve datma ajan, petrol bazl; krem merhem, kozmetik ve saç bakm ürünlerinde kullanlan Polietilen Glikol (PEG) hakknda bilgi.
Polietilen Glikol Nedir? Zararl mdr?
(polyethylene glycol, PEG, poly(oxyethylene), polyglycol, polyether glycol)
Özellikleri: Molekül arl aral 200 den 6000 e kadardr.Özellikleri ve kullanm alanlar, molekül arlna göre deiim gösterir.(Örnek, PEG300, PEG400 vb.) Temiz, renksiz, kokusuz ve viskoz bir svdr. Su, pek çok alkol ve organik solventlerle belirli oranlarda karabilir ve de çözünebilir. Pek çok kimyasal aanda inört tür. Düük buhar basnçlarnda hizrolize olmaz ya da bozunmaz. Nem tutucu, nemlendirme ve datma ajan, petrol bazldr.
Kullanm Alanlar: Molekül arlna göre kullanm alanlarda deiiklik gösterir.Belli bal kullanm alanlar; plastikletirici ve yumuatc olarak salk ve kozmatik sektöründe merhem, krem vb. preparatlarda, cila, kat kaplama, makine ve kalp yalarnda, solvent ve binderlerde, izin verilen miktarlarda gda sektöründe kullanlmaktadr. Genellikle krem merhem, kozmetik ve saç bakm ürünlerinde kullanlr.
PEG 200,300,400 ve 600 sulu formülasyonlarda yüzey aktif karmlarn çözmek için temizleyici endüstrisinde ve deterjanlarda kullanlrlar. PEG çeitleri, yüksek solvent gücüne ve pigment ve boyalarn bir çoklar için datc kapasiteye sahiptir ve bazik boyalar ve baz boya bazlar için etkili çözücülerdir. Yüksek kapatlckla mürekkepleri formüle etmek için ofis tedarik endüstrisinde kullanlrlar. Mürekkebin younluu kat ve sv PEG çeitlerinin karm kullanlarak kontrol altna alnabilir. PEG çeitleri fleksografik mürekkeplerde bazik boyalar için solventler olarak kullanlabilirler. Benzer bir ekilde, sv ve hamur pigment preparatlar, tekstilde hamur koyulatrclar, boya ve saramik endüstrisinde çözücü ve datc ortam olarak kullanlabilirler.
Zararlar: Polietilen Glikol (damardan verildiinde) öldürücü kalp krizleri görülmütür, merkezi sinir sistemi depresyonu ve deri yanna neden olabildii gözlemlenmitir.
PEG 200 Özellikleri
Renksiz, kokusuz ve yapkan sv. Karabilir ve su, birçok alkol ve organik çözücü ile çözünür.
Molekül arl : 190 – 210
Görünüm: berrak sv
Nem % 0.2 max
Hidroksil Deeri 535-590 (mg KOH / g)
pH 5-7
Özgül arlk 1.12 – 1.13DIOXANE 1ppm mak
Vizkozite 50 cP’de 25 C
PEG mono etilen glikol veya dietilen glikol polimerizasyonunda etilen oksit ve su varlnda polietilen glikol elde edilir. PEG’e ksaltlm polietilen glikol, polioksietilen veya poli etilen oksit olarak da adlandrlr. Suda çözünür ve toksik olmayan sentetik polieter.
Polietilen Glikoller (PEG 200, PEG 300 ,PEG 400 ..) için Tipik Bilinen Uygulamalar
Yaptrclar
Kimyasal Ara Maddeler
Yemek paketleme
Mürekkepler
Yalar
Kalp Ayrc
Plastifiyan
ÜRÜN DETAYI & PEG 20 HAKKINDA BLGLER
Polietilen glikol 200 (PEG 200) oda scaklnda berrak, renksiz bir svdr. Polietilen glikol 200 (PEG-200, polietilen glikol monostearat), H- (O – CH2 – CH2) n – OH kimyasal yapsna sahip bir polieter bileiidir. Geleneksel olarak, petrol bazl kaynaklardan elde edilir. PEG-200 geni bir potansiyel kullanm alanna sahiptir. PEG 200 birçok farkl üründe köpük giderici bir ajan, yalayc ve viskozite deitiricidir. PEG-200 ayrca taze meyve için bir kaplama, metal ileme svlarnda bir çözücü olarak, lateks boyalarda bir balayc ve deitirici olarak ve mürekkeplerde ve andrclarda bir nemlendirici olarak kullanlr.
PEG-200’e dayanan spesifik endüstriler kozmetik, salk ve tp, tekstil ve daha fazlasn içerir. Polietilen glikolun viskozitesi, 99 ° C’de, 4.0 ile 4.0 arasndadr, cSt. Maksimum su içerii% 0,20 ve maksimum% 0,05 asitlik oranna sahiptir. Normal artlar altnda PEG 200 stabil ve reaktif deildir, ancak açk alevlerden, dorudan güne ndan ve güçlü oksitleyicilerden uzak tutulmaldr. Drum ve Isotanks, PEG 200 ambalajn kullanabilir.
PEG için moleküler arlk aral 200 ila 6000 arasndadr. Uygulama alan ve özellikleri moleküler arla göre deiir (Örnek, PEG200, PEG400 vb.) Temiz, renksiz, kokusuz ve viskoz bir svdr. Karabilir ve su, birçok alkol ve organik çözücü ile çözünür. Birçok kimyasal a düüktür. PEG 200 düük buhar basnçlarnda hidrolize olmaz veya ayrmaz. PEG 200 nem tutucu, nemlendirici ve datc madde, petrol bazldr.
PEG 200,300,400 ve 600 temizlik endüstrisinde ve yüzey aktif maddeleri sulu formülasyonlarda çözmek için deterjanlar kullanlr. PEG dereceleri, birçok pigment ve boya için yüksek çözücü kuvvetine ve dalma kapasitesine sahiptir ve bazik boyalar ve baz boya bazlar için etkili çözücülerdir. Ofis tedarik endüstrisinde yüksek yapma özelliine sahip mürekkepleri formüle etmek için kullanlrlar. Mürekkebin younluu kat ve sv PEG 200, PEG400, PEG600, çeitlerinin bir karm kullanlarak kontrol edilebilir. PEG kaliteleri, fleksografik mürekkeplerdeki bazik boyalar için çözücü olarak kullanlabilir.
Benzer ekilde PEG 200 sv ve kat pigmenti preparatlar, tekstilde kat kvamlatrclar olarak, boya ve saramik endüstrilerinde çözücüler ve datclar olarak kullanlabilir. Polietilen Glikol (intravenöz olarak uygulandnda) ölümcül kalp krizi, merkezi sinir sistemi depresyonu ve cilt yanklar göstermitir.PEG endüstriyel imalattan ilaca kadar birçok uygulamaya sahip bir polieter bileiidir. PEG, PEG 200, PEG 400 vb. Moleküler arlna bal olarak polietilen oksit (PEO) veya polioksietilen (POE) olarak da bilinir. PEG yaps genellikle H- (O-CH2-CH2) n-OH olarak ifade edilir.PEG-200 geni bir potansiyel kullanm alanna sahiptir. Birçok farkl üründe köpük giderici bir ajan, yalayc ve viskozite deitiricidir. PEG-200 ayrca taze meyve için bir kaplama, metal ileme svlarnda bir çözücü olarak, lateks boyalarda bir balayc ve deitirici olarak ve mürekkeplerde ve andrclarda bir nemlendirici olarak kullanlr.
PEG 200-300-400-600;
Mineral ya,
Tekstil, deri,
Metal ve deterjan endüstrisinde balmumu,
Parafin ve çözücü emülsiyonlar,
Emülgatör,
Ara çözücü,
Viskozite düzenleyici,
Nemlendirici,
Boya ahap kozmetik ve deri sanayinde kullanlr.
PEG 200
PEG 200
N° CAS de PEG 200 : 25322-68-3
“Pas terrible” dans toutes les catégories.
Origine(s) : Synthétique
Nom INCI : PEG 200
Additif alimentaire : E1521
Classification : PEG/PPG, Composé éthoxylé, Glycol, Polymère de synthèse
Fonctions de PEG 200 (INCI)
PEG 200 est Humectant : Maintient la teneur en eau d’un cosmétique dans son emballage et sur la peau
PEG 200 est Solvant : Dissout d’autres substances
PEG 200 est présent dans 0.02% des cosmétiques.
DESCRIPTIONS DU PRODUIT
Polymère thermoplastique obtenu par la polymérisation de l’oxyde d’éthylène; les différents types de PEG se différencient selon leur poids moléculaire moyen dont ils tirent le nom. Le PEG 200 est soluble dans l’eau et dans beaucoup de solvants organiques, cependant en augmentant le poids moléculaire, on fait diminuer aussi bien la solubilité que l’hygroscopicité. L’application la plus reconnue des polyéthylèneglycols concerne la consolidation des bois gorgés d’eau.
CARACTÉRISTIQUES PHYSIQUES ET CHIMIQUES:
Formule du PEG 200: HO(CH2CH2O)nCH2CH2OH
Aspect du PEG 200: liquide clair
Poids molécolaire du PEG 200(uma) : env. 200
Temp. de fusion du PEG 200 (°C) : env. -40
Le PEG 200 (Polyéthylène Glycol 200) est un liquide clair et incolore fabriqué à partir de déchets de canne à sucre, il est donc naturellement dérivé et renouvelable. Il est complètement soluble dans l’eau et a un poids moléculaire moyen de 190 à 210. Les PEGS sont un autre groupe de produits avec une liste incroyablement longue d’utilisations et d’applications allant des utilisations industrielles aux aliments et aux produits pharmaceutiques, et tout le reste.
PEG 200
PEG (200)
PEG 200 n o CAS 25322-68-3
PEG 200 EINECS n ° 500-038-2
Formule chimique PEG 200 (C2H4O) nH2O
Liquide d’apparence PEG 200
PEG 200 Pureté (%) 99
PEG 200 Densité (Kg / Litre) 1,1238
Point d’éclair PEG 200, ° C150
PEG 200 Point d’ébullition, ° C –
Formulaire de sécurité PEG 200 (Msds)