PEG 40 HYDROGENATED CASTOR OIL ( PEG 40 HDROJENE HNT YAI)
PEG-40 CASTOR OIL
CAS NUMBER:61788-85-0
SYNONYMS:HYDROGENATED CASTOR OIL, ETHOXYLATED; POLYETHYLENE GLYCOL 2000 HYDROGENATED CASTOR OIL; POLYOXYETHYLENE (40) HYDROGENATED CASTOR OIL; CREMOPHOR RH 40; CREMOPHOR RH 40/60; HCO 40; HCO 50; HCO 60; NIKKOL HCO 60; akypo rox CO400; alkamuls CRH/40-C;castor oil (ricinus communis), hydrogenated, ethoxylated (40 mol EO average molar ratio);cremophor RH 40;croduret 40; emanon CH-40; findet ARH-52; lipocol HCO-40;nikkol HCO-40;nikkol HCO-40 pharm;polyethylene glycol40 hydrogenated castor oil; polyoxyethylene (40) hydrogenated castor oil;RTD HC-40;akypo rox CO400;alkamuls CRH/40-C;castor oil (ricinus communis), hydrogenated, ethoxylated (40 mol EO average molar ratio);cremophor RH 40;croduret 40;emanon CH-40;findet ARH-52;lipocol HCO-40;nikkol HCO-40;nikkol HCO-40 pharm;polyethylene glycol (40) hydrogenated castor oil;polyoxyethylene (40) hydrogenated castor oil;RTD HC-40;Cremophor® RH 40, Macrogolglycerol hydroxystearate, PEG-40 castor oil, Polyoxyl 40 hydrogenated castor oil;Castor oil, hydrogenated, ethoxylated;Polyoxyethylene hydrogenated castor oil;Hydrogenated Castor Oil Ethoxylate;PEG-40 Hydrogenated Castor Oil;Emulsifier HEL;Polyethyleneglycol castor oil, hydrogenated;PEG 40 Hydrogenated Castor Oil; T/N Unipeg CO40H; Ethox HCO-40; T/N: CASTOR HCO-40; Polyoxyethylene Hydrogenated Castor Oil; Tagat CH 40;Ethoxylated hydrogenated castor oil; Castor oil, hydrogenated, ethoxylated;RH40;hco60;hco50;hco40; peg-25; ARLATONEG; nikkolhco60;cremophorrh40;ARLATONE(TM) G;CreMophor RH60;peg40; peg 40; PEG40; PEG 40; PEG40HYDROGENATED CASTOR OIL;PEG 40 HYDROGENATED CASTOR OIL; PEG 40 HYDROGENATEDCASTOROIL; PEG 40 HYDROGENATED CASTOROIL;PEG 40 HYDROGENATED CASTOR OIL; peg40hydrogenatedcastoroil;peg40 hydrogenatedcastoroil;peg 40 hydrogenated castoroil; peg 40 hyrogenated castor oil; peg40hidrojenehintya; peg40 hidrojenehintya; peg 40 hidrojene hintya; peg 40 hidrojene hint ya;PEG 40 HDROJENE HNT YAI; PEG40HDROJENEHNTYAI; PEG40 HDROJENEHNTYAI; PEG-40 HDROJENE HNT YAI;PEG-40; peg-40;• Castoroil,hydrogenated,ethoxylated ;castoroil,hydrogenated,ethoxylated,hco40; castoroil,hydrogenated,ethoxylated,hco50 castoroil,hydrogenated,ethoxylated,hco60 ;cremophorrh40 ;cremophorrh40/60hco40 ;hco50;hco60 ;Hydrogenatedcastoroil ,ethoxylated; nikkolhco60 ;peg-25 ;peg-25hydrogenatedcastoroil;peg40 hydrogenatecastoroilpcaisostearate; 61788-85-0;ethoxylated hydrogenated castor oil;ARLATONE(TM) G;POLYOXYETHYLENE FATTY GLYCERIDE;POLYOXYETHYLENE(10) HYDROGENATED CASTOR OIL;PEG-2 HYDROGENATED CASTOR OIL;PEG-5 HYDROGENATED CASTOR OIL;PEG-6 HYDROGENATED CASTOR OIL;PEG-7 HYDROGENATED CASTOR OIL;PEG-8 HYDROGENATED CASTOR OIL;PEG-10 HYDROGENATED CASTOR OIL;PEG-16 HYDROGENATED CASTOR OIL;PEG-20 HYDROGENATED CASTOR OIL;PEG-30 HYDROGENATED CASTOR OIL;PEG-35 HYDROGENATED CASTOR OIL;PEG-40 HYDROGENATED CASTOR OIL;PEG-45 HYDROGENATED CASTOR OIL;PEG-50 HYDROGENATED CASTOR OIL;PEG-54 HYDROGENATED CASTOR OIL;PEG-55 HYDROGENATED CASTOR OIL;PEG-80 HYDROGENATED CASTOR OIL;PEG-100 HYDROGENATED CASTOR OIL;PEG-200 HYDROGENATED CASTOR OIL;ARLATONEG; POLYETHYLENEGLYCOLOFHYDROGENATEDCASTOROILPOLYETHYLENEGLYCOLESTEROFHYDROGENATEDCASTOROIL; POLYETHOXYLATEDHYDROGENATEDCASTOROIL; CREMOPHOR(R)RH40;POLYOXYETHYLENE50HYDROGENATEDCASTOROIL; CASTOROILPOLYOXYLHYDROGENATED; POLYOXYETHYLENEHYDROGENATEDCASTOROIL60; POLYOXYETHYLENE-60HYDROGENATEDCASTOROIL; PEGHYDROGENATEDCASTOROILS; Rizinusl(C16-C18), mittlerer Ethoxylierungsgrad 5-60 EO; Polyethyleneglycol castor oil, hydrogenated;Cosmetic Ingredients & Chemicals;61778-85-0;CreMpphor CO 40;CreMophor RH 40 (Polyoxyl 40 Hydrogenated castor Oil);CreMophor RH60;CreMophor CO40;Ethoxylated hydrogen;storoil,hydrogenated,ethoxylated;EMulgine HRE 40;akypo rox CO400;alkamuls CRH/40-C; castor oil (ricinus communis), hydrogenated, ethoxylated (40 mol EO average molar ratio);cremophor RH 40;croduret 40; emanon CH-40;findet ARH-52;lipocol HCO-40;nikkol HCO-40;nikkol HCO-40 pharm;polyethylene glycol (40) hydronated castor oil;polyoxyethylene (40) hydrogenated castor oil;RTD HC-40;Polyoxyethylene castor oil;castor oil 40 EO;
castor oil 40 etoksile;hint ya etoksile;hint ya 40 etoksile;
What is PEG-40 Hydrogenated Castor Oil?
PEG-40 Hydrogenated Castor Oil is the polyethylene glycol (PEG) derivative of hydrogenated castor oil. It’s uses are common in this form as an emulsifier and a fragrance ingredient.PEG-40 has the FDA-approval for external use. Studies have found PEG-40 to be safe in concentrations of up to 100%. Generally speaking, PEGs are not skin irritants. PEG-40’s molecular weight of 40 means it is only minimally absorbed into the skin.However, there is quite a bit of controversy over the safety of PEG-40. While the FDA approved it for external use, the Cosmetics Database found it to be moderately hazardous. According to the database, contamination is possible with potentially toxic impurities. Studies show that applying products containing PEG-40 to severe burns can result in kidney toxicity. So never apply to broken skin due to the risk of organic toxicity.How can PEG-40 be so toxic when absorbed by the body when pure castor oil is so safe? To understand that, we need to look at the scientific process of ethoxylation.PEG-40 is a result of the ethoxylation process. When hydrogenated castor oil is ethoxylated with ethylene oxide, which is a petroleum-based chemical, the process may introduce the carcinogen 1,4 dioxane as a contaminant. It also may not. This is a possibility each time the ethoxylation process occurs. However, it is not a guarantee that the product result is without contamination.PEG 40 Hydrogenated Castor Oil is the polyethylene glycol derivatives of hydrogenated castor oil, and is an amber colored, slightly viscous liquid that has a naturally mildly fatty odor. It is used in cosmetics and beauty products as an emulsifier, surfactant, and fragrance ingredient, according to research.PEG Castor Oils and PEG Hydrogenated Castor Oils are a family of polyethylene glycol derivatives of castor oil and hydrogenated castor oil that are used in over 500 formulations representing a wide variety of cosmetic products. They are used as skin conditioning agents and as surfactants (emulsifying and or solubilizing agents). The PEG Castor Oils and PEG Hydrogenated Castor Oils include various chain lengths, depending on the quantity of ethylene oxide used in synthesis. Although not all polymer lengths have been studied, it is considered acceptable to extrapolate the results of the few that have been studied to allingredients in the family. Because a principal noncosmetic use of PEG Castor Oils is as solvents for intravenous drugs, clinical data are available that indicate intravenous exposure can result in cardiovascular changes. Results from animal studies indicate very high LD50 values, with some evidence of acute nephrotoxicity in rats but not in rabbits. Short-term studies with intravenous exposure produced some evidence of toxicity in dogs but not in rabbits. Intramusuclar injection produced no toxicity in several species, including dogs. Subchronic oral studies also were negative. No dermal or ocular irritation was observed in studies in rabbits. Irritation was seen during induction, but no sen-sitization was found on challenge in guinea-pig studies using up to 50% PEG-35 Castor Oil; however, thisingredient was found to be a potent adjuvant in guinea pigs and mice. No evidence of developmental toxicity was seen in mice and rat feeding studies. Theseingredients, tested as vehicle controls, produced no mutagenic or carcinogenic effect. Clinical data are generally negative for irritation and sensitization, although some anaphylactoid reactions have been seen in studies of intravenous drugs in which PEG-35 Castor Oil was used as the vehicle. Because the maximum concentration used in animal sensitization studies was 50% for PEG Castor Oils and 100% for PEG Hydrogenated Castor Oils, it was concluded that PEG Castor Oils are safe for use in cosmetic formulations up to a concentration of 50% and that PEG Hydrogenated Castor Oils are safe as used in cosmetic formulations.t’s a non-ionic surfactant that behaves as a foam booster and solubilizer of oils in water based products. (Unlike some other solubilizers, it won’t suppress foam. Yay!) It can be used in the heated phase or the cool down phase of a product at up to 100%.
Functions:
PEG 40 Hydrogenated Castor Oil is the polyethylene glycol derivatives of hydrogenated castor oil, and is an amber colored, slightly viscous liquid that has a naturally mildly fatty odor. It is used in cosmetics and beauty products as an emulsifier, surfactant, and fragrance ingredient, according to research.PEGs are not considered to be irritants or sensitizers, and are CIR and FDA approved for use, but not on broken skin. The CIR has found that PEG 40 Hydrogenated Castor Oil is safe for use in concentrations of up to 100% without causing irritation, although it has been shown to increase the sensitization potential of other ingredients. It’s molecular weight of 40 means that it is minimally absorbed by the skin.Despite the many fears regarding PEGs, they are seen as an ingredient in a large number of products because of their diverse properties. In a study published in the Toxicology journal in 2005, entitled “Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products,” it was concluded that: “Taking into consideration all available information from related compounds, as well as the mode and mechanism of action, no safety concern with regard to these endpoints could be identified. Based on the available data it is therefore concluded that PEGs of a wide molecular weight range (200 to over 10,000), their ethers (laureths, ceteths, ceteareths, steareths, and oleths), and fatty acid esters (laurates, dilaurates, stearates, distearates) are safe for use in cosmetics.”
Safety Measures/Side Effects:
The Cosmetics Database found PEG 40 Hydrogenated Castor Oil to be a moderate hazard depending on use and notes contamination and toxicity concerns.According to a study published in the International Journal of Toxicology, PEGs (including PEG 40 Hydrogenated Castor Oil) can contain harmful impurities, including: Ethylene Oxide, known to increase the incidences of uterine and breast cancers and of leukemia and brain cancer, according to experimental results reported by the National Toxicology Program; 1,4-dioxane, a known carcinogen; PAHs, known to increase the risk of breast cancer; lead; iron; and arsenic .Products and formulas containing PEGs should not be used on broken or irritated skin. Although PEGs are considered safe for use topically on healthy skin, studies showed that patients suffering from severe burns were treated with PEG-based antimicrobial cream; this treatment resulted in kidney toxicity. “The PEG content of the antimicrobial cream was determined to be the causative agent. However, no evidence of systemic toxicity occurred in studies with intact skin. Because of the observation of kidney effects in burn patients, the CIR Expert Panel qualified their conclusion on the safety of the PEG ingredients to state that cosmetic formulations containing these ingredients should not be used on damaged skin”.
Castor Oil Ethoxylates have many uses, primarily as nonionic surfactants in various formulations both, industrial & domestic. These are also used as cleaning agents, antistatic agents, dispersants or emulsifiers, defoamers, softeners in textile formulations. Also these are used as emulsifiers, solubalizers in cosmetics , health care & agrochemical formulations. Castor oil ethoxylates are a type of nonionic vegetable oil ethoxylate based on castor oil which is composed of traditional fatty acids like stearic acid but also the unique ricinoleic acid.The ethoxylates act as the emulsifier, solubilizers, anti-static agents, and lubricants in various market segments including home care, personal care, and agrochemicals.
PEG-40 Hidrojene Hint Ya Nedir?
PEG-40 Hidrojene Hint Ya, hidrojene hint yann polietilen glikol (PEG) türevidir. Kullanmlar yaygn bu formda bir emülgatör ve bir koku bileeni olarak. PEG-40, harici kullanm için FDA onayna sahiptir. Aratrmalar bulundu PEG-40,% 100’e kadar olan konsantrasyonlarda güvenlidir. Genel olarak konumak gerekirse, PEG’ler ciltte tahri edici deildir. PEG-40’n molekülü 40 arl sadece cilde emilir anlamna gelir.Ancak, güvenlik konusunda biraz ihtilaf vardr PEG-40. FDA, harici kullanm için onaylarken, Kozmetik Veri Taban, orta derecede tehlikeli olduunu tespit etti. Veri tabanna göre, potansiyel olarak zehirli katklarla kirlenme mümkündür. Çalmalar, ürünlerin uygulanmasnn olduunu gösteriyor PEG-40 içeren ciddi yanklar için böbrek toksisitesi ile sonuçlanabilir. Bu nedenle organik risk nedeniyle krk deriye asla uygulanmamaldr. Toksisite.Neden saf yalar çok güvenli olduunda vücut tarafndan emildiinde PEG-40 çok toksik olabilir? Bunu anlamak için ihtiyacmz var. Etoksilasyonun bilimsel sürecine bakmak için. PEG-40, etoksilasyon sürecinin bir sonucudur. Hidrojenli castor olduunda petrol, petrol bazl bir kimyasal olan etilen oksitle etoksilatlanmtr, ilem karsinojen 1,4’ü tantabilir bir kirletici olarak dioksan. Ayrca olmayabilir. Bu etoksilasyon ilemi her olutuunda bir olaslktr. Ancak öyle ürün sonucunun kirletmeden olduunu garanti etmez.PEG 40 Hidrojene Hint ya polietilen glikol hidrojenlenmi hint ya türevleri ve doal olarak hafif yal bir kehribar renkli, hafif viskoz bir svdr koku. Kozmetik ve güzellik ürünlerinde emülgatör, yüzey aktif madde ve koku maddesi olarak kullanlr.Aratrma PEG Castor Yalar ve PEG Hidrojene Castor Yalar, hint ya ve polietilen glikol türevleridir.Çok çeitli kozmetik ürünleri temsil eden 500’den fazla formülasyonda kullanlan hidrojene hintya. Onlar cilt bakm maddeleri olarak ve yüzey aktif maddeler olarak kullanlr (emülsifiye edici ve / veya çözündürücü maddeler). PEG Castor Yalar ve PEG Hidrojenlenmi Castor Yalar, sentezde kullanlan etilen oksit miktarna bal olarak çeitli zincir uzunluklarn içerir.Tüm polimer uzunluklar incelenmemesine ramen, birkaçnn sonuçlarnn tahmin edilmesi kabul edilebilir.Aile içinde allingredients üzerinde çallmtr. Çünkü PEG Castor Yalarnn temel nonkosmetik kullanm çözücüdür. ntravenöz ilaçlar için intravenöz maruz kalmann kardiyovasküler deiikliklere yol açabileceini gösteren klinik veriler mevcuttur.Hayvan çalmalarndan elde edilen sonuçlar, sçanlarda akut nefrotoksisite ile ilgili baz kantlarla birlikte çok yüksek LD50 deerlerini göstermektedir tavan. ntravenöz maruziyetle yaplan ksa süreli çalmalar, köpeklerde deil, tavanlarda baz toksisite kantlar üretmitir. Intramusuklar enjeksiyon, köpekler dahil olmak üzere çeitli türlerde toksisite yaratmad. Subkronik oral çalmalar da vard negatif. Tavanlarda yaplan çalmalarda dermal veya oküler irritasyon gözlenmedi. ndüksiyon srasnda tahri oldu, ama hayr % 50’ye varan PEG-35 Castor Oil kullanarak gine-domuz çalmalarnda zorlamada sen-sitisation bulundu; Ancak, bu yaz Gine domuzlarnda ve farelerde güçlü bir adjuvan olduu bulunmutur. Farelerde ve sçanlarda geliimsel toksisite kant görülmemitir beslenme çalmalar. Araç kontrolleri olarak test edilen bu maddeler mutajenik veya kanserojen etki göstermemitir. Klinik veriler çalmalar srasnda baz anafilaktoid reaksiyonlar görülmesine ramen genellikle irritasyon ve duyarllama için negatiftir. PEG-35 Castor Oil’in araç olarak kullanld intravenöz ilaçlar. Çünkü hayvanda kullanlan maksimum konsantrasyon PEG Castor Yalar için% 50, PEG Hidrojenlenmi Castor Yalar için% 100 duyarllk çalmalar yapld. Castor Yalar,% 50’lik bir konsantrasyona kadar kozmetik formülasyonlarda ve PEG Hidrojenlenmi Castor Yalarnda kullanm için güvenlidir. Kozmetik formülasyonlarda kullanld gibi güvenlidir. Köpük güçlendirici ve yalarn çözücüsü olarak davranan iyonik olmayan bir yüzey aktif madde Su bazl ürünler. (Dier baz çözücülerden farkl olarak, köpüü bastrmaz. Yay!) Istlm fazda kullanlabilir veya bir ürünün souma faz% 100’e kadar.
Fonksiyonlar:
PEG 40 Hidrojene Hint ya, hidrojene Hint ya polietilen glikol türevleri olup, kehribar renklidir. Doal olarak hafif yal bir kokusu olan hafif viskoz sv. Kozmetik ve güzellik ürünlerinde aratrmalara göre emülgatör, yüzey aktif madde ve koku maddesi içerir. PEG’ler tahri edici olarak kabul edilmez veya hassaslatrclar ve CIR ve FDA kullanm için onaylanm, ancak krk cilt üzerinde deil. CIR, PEG 40 Hidrojenli olduunu buldu Castor Oil, tahrie yol açmadan% 100’e kadar olan konsantrasyonlarda kullanm için güvenlidir; Dier malzemelerin hassaslama potansiyelini arttrr. Molekül arl 40, en az emildii anlamna gelir cilt tarafndan. Birçok PEG ile ilgili korkularna ramen, onlar nedeniyle çok sayda ürün bir madde olarak görülüyor onlarn çeitli özellikleri. 2005 ylnda Toxicology dergisinde yaynlanan bir çalmada, “Güvenlik deerlendirmesi” balkl Polietilen glikoller (PEG’ler) ve bunlarn kozmetik ürünlerinde kullanld gibi türevleri “u sonuca varmtr: ilgili bileiklerden elde edilen tüm bilgilerin yan sra eylem modu ve mekanizmas, güvenlik yok bu son noktalar ile ilgili kayg belirlenebilir. Mevcut verilere dayanarak, bu nedenle PEG’lerin olduu sonucuna varlmtr. Geni bir moleküler arlk aralnn (200 ila 10,000 arasnda), eterlerinin (lauret’ler, setetler, setearetler, stearet ve oletlerin) ve yal asit esterleri (lauratlar, dilauratlar, stearatlar, distearatlar) kozmetikte kullanm için güvenlidir. ”
Güvenlik Önlemleri / Yan Etkiler:
Kozmetik Veri Taban, PEG 40 Hidrojene Hint Yann kullanm ve notlara bal olarak orta düzeyde bir tehlike olduunu tespit etti.Kontaminasyon ve toksisite endieleri. Uluslararas Toksikoloji Dergisi, PEGs yaynlanan bir çalmaya göre (PEG 40 Hidrojene Hint Ya dahil), aadakiler dahil olmak üzere zararl yabanc maddeler içerebilir: Etilen Oksit, rahim ve meme kanserleri ve lösemi ve beyin kanseri insidans, deneysel sonuçlara göre Ulusal Toksikoloji Program; Bilinen bir karsinojen olan 1,4-dioksan; Meme kanseri riskini artrd bilinen PAH’lar; öncülük etmek; Demir; ve arsenik. PEG içeren ürünler ve formüller krk veya tahri olmu cilt üzerinde kullanlmamaldr. PEG’ler olmasna ramen Salkl cilt üzerinde topikal kullanm için güvenli olduu düünüldüünde, çalmalar iddetli yanktan muzdarip hastalarn tedavi edildiini göstermitir. PEG bazl antimikrobiyal krem ??ile; Bu tedavi böbrek toksisitesi ile sonuçland. “Antimikrobiyal kremin PEG içerii nedensel ajan olduu belirlenmitir. Bununla birlikte, salam deri ile yaplan çalmalarda sistemik toksisite kant olmamtr. Yank hastalarnda böbrek etkilerinin gözlemlenmesi nedeniyle CIR Uzman Paneli,bu bileenleri içeren kozmetik formülasyonlarn kullanlmamas gerektiini belirtmek için PEG bileenlerinin güvenlii.
Hint Ya Etoksilatlar, bata endüstriyel ve evsel olmak üzere çeitli formülasyonlarda noniyonik yüzey aktif maddeler olmak üzere birçok kullanma sahiptir. Bunlar ayrca, tekstil formülasyonlarnda temizlik maddeleri, antistatik maddeler, datclar veya emülsifiye ediciler, köpük gidericiler, yumuatclar olarak kullanlr. Ayrcabunlar, emülsiyonlatrclar, kozmetikte çözücü maddeler, salk bakm ve zirai ilaç formülasyonlar olarak kullanlr. Hint ya etoksilatlar, stearik asit gibi geleneksel ya asitlerinden ve ayn zamanda benzersiz risinoleik asitlerden oluan hint ya bazl bir nonyonik bitkisel ya etoksilatdr. Etoksilatlar, emülsifletirici, çözündürücüler, anti-statik maddeler ve çeitli yalayclar olarak ilev görürler. Evde bakm, kiisel bakm ve zirai ilaçlar içeren pazar segmentleri.