POLYETHYLENIMINES
Polyethylenimines are a hydrophilic cationic polymer widely used as a nonviral nucleotide delivery reagent.
Polyethylenimines are widely used in many applications due to their polycationic character.
Polyethylenimines have been extensively studied as a vehicle for nonviral gene delivery and therapy.
CAS Number: 9002-98-6
EC Number: 205-793-9
Molecular Formula: (C2H5N)x
Molecular Weight: 43.069
Synonyms: Poly(iminoethylene), Polyaziridine, Poly[imino(1,2-ethanediyl)], MFCD00084427, Aziridine, homopolymer, aziridine, homopolymer, PEI, PEI-10, polyethyleneimine, branched, m.w. 1800, Aziridine,homopolymer, polyethylenimine(10,000), POLYETHYLENEIMINE, BRANCHED, PEI-35, PEI-2500, PEI-1500, polyethylenimine(20,000), Ethyleneimine,homopolymer, Aziridine, Ethylenimine, Azacyclopropane, Everamine, Polymin, Dimethyleneimine, Polyethyleneimine, Dihydroazirene, Dihydroazirine, Polymine P, Aziran, Polymin P, ETHYLENEIMINE, Polymin FL, Ethylene imine, Montrek 6, Ethylenimine resins, Everamine 50T, Poly(ethylenimine), Polyaziridine, p 1000 (polyamine), epamine 150t, epomin sp 110, epomin p 500, epomin p 003, xa 1007, polymin g 15m, poly (ethylenimine), lupasol g 35, pei, polymin fl, pr 20 (release agent), pei 1000, polymin p, k 203c, pei-30, polymin sna, sedipur cl 930, epomin sp 300, pei 18, aziridine,polymers,homopolymer, pei-700, everamine, everamine 210t, pei 100, polyethyleneimine, epomin sp 200, epomin sp 003, dow pei-18, pei-10, montrek 6, epomin p 1500, el 402, polymin g 100, pei-275, lupasol wf, epomin sp 012, ethylenimine, polymers, pei-250, pei-600, epomin sp 1000, epomin d 3000, polymin 6, montrek 1000, everamine 150t, dow pei-6, p 600xe, epomine 150t, dow pei-600e, 15t, lupasol sk, pei 2, epomin sp 018, pei-45, polymin g 35, polymin, epomin sp 006, corcat p 18, pei-7, lugalvan g 15, epomine p 1000, everamine 50t, polymin hs, pei 400, polyethylenimine, m.w.600, pei 600, ethoxylated polyethylenimine, m.w. 60,000, p 0381, epomin 150t, ethylenimine resins, p 1000, 2mb, bufloc 595, pei 1120, polyethyleneimine, 50 % solution in water, lugalvan g 35, pei-14m, corcat p 145, pei-35, pei 12, cf 218 (polymer), corcat p 600, montrek 600, epomine 1000, corcat p 150, epomin p 1000, lugalvan g 20, aziridine homopolymer,
Polyethylenimine or polyaziridine is a polymer with repeating units composed of the amine group and two carbon aliphatic CH2CH2 spacers.
Linear Polyethylenimines contain all secondary amines, in contrast to branched Polyethylenimines which contain primary, secondary and tertiary amino groups.
Totally branched, dendrimeric forms were also reported.
Polyethylenimine is produced on an industrial scale and finds many applications usually derived from its polycationic character.
Polyethylenimines are polymer with repeating units composed of ethylene diamine groups.
Polyethylenimines contain primary, secondary and tertiary amino groups.
Polyethylenimines are hydrophilic polymer widely used as a non-viral synthetic vector for invivo delivery of therapeutic nucleic acids.
Polyethylenimines are high-charge cationic polymer that readily binds highly anionic substrates.
Industrially, linear Polyethylenimines can improve the appearance of negatively charged dyes by modulating their properties and improving their adherence to surfaces.
Polyethylenimines are organic macromolecules with high cationic-charge-density potential.
Polyethylenimines can ensnare DNA as well as attach to cell membrane, Polyethylenimine also retains a substantial buffering capacity at virtually any pH.
A significant advantage of Polyethylenimines lies in their superior transfection efficiency, surpassing many conventional methods.
Polyethylenimines’s capacity to surmount cellular barriers and directly deliver genetic material to the nucleus ensures robust and dependable gene expression, catering to a wide spectrum of research needs spanning from fundamental inquiries to therapeutic interventions.
Moreover, Polyethylenimines provide researchers with extensive flexibility in experimental design, allowing for precise adjustments of transfection parameters to achieve optimal outcomes.
This versatility empowers scientists to explore diverse avenues in gene function studies, protein expression analyses, and gene therapy investigations, unleashing new possibilities in molecular biology and genetic research.
Polyethylenimines are a biocompatible polymer that can be used in wastewater treatment.
Polyethylenimines are soluble in water and has surfactant properties.
Polyethylenimines are a hydrophilic polymer and a gene carrier, which can be conjugated with dextran to enhance the stability of polycationic vectors.
Polyethylenimines are also used in the preparation of cationic poly(lactic-co-glycolic acid) (PLGA) nanoparticles for potential usage in gene therapy.
Polyethylenimines can also be grafted on polyacrylonitrile (PAN) fiber membrane for the removal of hexavalent chromium (VI) from wastewater.
Polyethylenimines are pale yellow viscous liquid with an amine-like odor.
Polyethylenimines are highly basic and positively charged aliphatic polymers, containing primary, secondary and tertiary amino groups in a 1:2:1 ratio.
Every third atom of the polymeric backbone is therefore an amino nitrogen that may undergo protonation.
As the polymer contains repeating units of ethylamine, Polyethylenimines are also highly watersoluble.
Polyethylenimines are available in both linear and branched forms with molecular weights ranging from 700 Da to 1000 kDa.
Polyethylenimine is a hydrophilic cationic polymer widely used as a nonviral nucleotide delivery reagent.
Branched Polyethylenimine can be synthesized by cationic ring-opening polymerization of aziridine.
Polyethylenimine-based particles can also be used as adjuvants for vaccines.
Owing to Polyethylenimine’s excellent physicochemical properties, Polyethylenimine is applied in many fields like the separation and purification of proteins, carbon dioxide absorption, drug carriers, effluent treatment, and biological labels.
Polyethylenimine, a cationic polymer, has revolutionized the field of transfection with Polyethylenimine’s exceptional efficiency and adaptability.
Polyethylenimine’s unique capability to create stable complexes with nucleic acids enables the effective transfer of DNA, RNA, and proteins into various cell types, including those historically challenging to transfect.
A significant advantage of Polyethylenimine lies in its superior transfection efficiency, surpassing many conventional methods.
Polyethylenimine’s capacity to surmount cellular barriers and directly deliver genetic material to the nucleus ensures robust and dependable gene expression, catering to a wide spectrum of research needs spanning from fundamental inquiries to therapeutic interventions.
Moreover, Polyethylenimine provides researchers with extensive flexibility in experimental design, allowing for precise adjustments of transfection parameters to achieve optimal outcomes.
This versatility empowers scientists to explore diverse avenues in gene function studies, protein expression analyses, and gene therapy investigations, unleashing new possibilities in molecular biology and genetic research.
Uses of Polyethylenimines:
Polyethylenimines are used stable in combination with other positively charged particles.
Polyethylenimines are used layer by layer construction of nanoparticle surfaces.
Polyethylenimines are used binding to negatively charged substrates or larger particles.
Polyethylenimines are used color engineering.
Polyethylenimines are used the degree of polymerization used in the paper industry is about 1 00.
Polyethylenimines have high reaction activity, can react with the hydroxyl group in cellulose and cross-linking polymerization, so that the wet strength of the paper.
Polyethylenimines are used the presence of any acid, base, and aluminum sulfate will affect the wet strength and retention.
Polyethylenimines are used as the wet strength agent of the respiratory paper without sizing, the retention agent and the beating agent in the paper making process can reduce the beating degree of the pulp, improve the dehydration ability of the paper, and speed up the drainage of the pulp, the fine fibers in white water are easy to flocculate.
Polyethylenimines can also be used to treat cellophane, reduce wetting deformation of the paper, etc.
Polyethylenimines can also be used for fiber modification, printing and dyeing auxiliaries, ion exchange resins, etc.
Polyethylenimines have a strong binding force to acid dyes and can be used as a fixing agent for acid dye dyeing paper.
Primary amines on the Polyethylenimines are used to covalently link BPEI to carboxyl functionalized nanoparticles to generate a robust BPEI surface that is highly positively charged.
Polyethylenimines can be used as a precursor to synthesize conjugated polyplexes for efficient gene transfection.
Conjugation of Polyethylenimines with Jeffamine polyether and guanidinylation of the amino groups of Polyethylenimine reduce the cytotoxicity of the polyplexes and protect them from aggregation in the presence of serum proteins.
Bamboo charcoal impregnated with Polyethylenimines can be used as a CO2 adsorbent.
Numerous amino groups present in Polyethylenimines can react with CO 2 due to acid-alkali interaction and enhance the adsorption capacity of bamboo charcoal.
Polyethylenimines can also be used to prepare cross-linked water-soluble polymers with high coordination capabilities towards organic drug molecules.
Owing to its excellentphysicochemical properties, Polyethylenimines are applied in many fields like the separation and purification of proteins, carbon dioxide absorption, drug carriers, effective treatment, and biological labels.
Polyethylenimines are widely used as transfection reagent.
Polyethylenimines, a cationic polymer, have revolutionized the field of transfection with their exceptional efficiency and adaptability.
Polyethylenimines unique capability to create stable complexes with nucleic acids enables the effective transfer of DNA, RNA, and proteins into various cell types, including those historically challenging to transfect.
Polyethylenimines are widely used in many applications due to their polycationic character.
Unlike Polyethylenimine’s linear equivalent, branched Polyethylenimines contain primary, secondary, and tertiary amines.
Primarily utilized in industrial applications, high molecular weight Polyethylenimines have been used as a flocculating agent, textile coating, adhesion promoter, enzyme carrier, and as a material for CO2 capture.
Polyethylenimines are used Strongly cationic polymer that binds to certain proteins.
Polyethylenimines are used as a marker in immunology, to precipitate and purify enzymes and lipids
Polyethylenimines have been shown to have receptor activity and can be used as a model system for studying the effects of polymers on living cells.
Polyethylenimines may also be used as an adjuvant to increase the efficacy of other drugs or as a means of drug delivery.
Polyethylenimines also have some glycol ethers, which can help prevent Polyethylenimine from being degraded by hydrogen fluoride.
For a long time, Polyethylenimines have been also used in non-pharmaceutical processes, including water purification, paper and shampoo manufacturing.
Polyethylenimine has been also reported that Polyethylenimines are relatively safe for internal use in animals and humans.
Polyethylenimines are widely used to flocculate cellular contaminants, nucleic acids, lipids and debris from cellular homogenates to facilitate purification of soluble proteins.
Enzymatic reactions in bioprocesses constitute another field in which Polyethylenimines were used: as an immobilizing agent for biocatalysts, as a soluble carrier of enzymes or in the formation of macrocyclic metal complexes mimicking metalloenzymes.
Polyethylenimines are also a common ingredient in a variety of formulations ranging from washing agents to packaging materials.
Polyethylenimines have been extensively studied as a vehicle for nonviral gene delivery and therapy.
Since its introduction in 1995, Polyethylenimines have been considered the gold standard for polymer-based gene carriers because of the excellent transfection efficiencies of Polyethylenimine’s polyplexes (complex of nucleic acid and polymer) in both in vitro and in vivo models.
Polycation-mediated gene delivery is based on electrostatic interactions between the positively charged polymer and the negatively charged phosphate groups of DNA.
In aqueous solution, Polyethylenimines condense DNA and the resulting PEI/DNA complexes, carrying a net positive surface charge, can interact with the negatively charged cell membrane and readily internalized into cells.
Polyethylenimines retain a substantial buffer capacity at virtually any pH and Polyethylenimine has been hypothesized that this simple molecular property is related to the efficiency of the complex multistage process of transfection.
As a matter of fact, the ‘proton sponge’ nature of Polyethylenimines are thought to lead to buffering inside endosomes.
The proton influx into the endosome, along with that of counter-anions (generally chloride anions), maintains the overall charge neutrality even if an increase of ionic strength inside the endosome is expected.
This effect generates an osmotic swelling and the consequent physical rupture of the endosome, resulting in the escape of the vector from the degradative lysosomal compartment.
The proton sponge hypothesis has been a subject of debate, speculation and research without reaching a general consensus about the real mechanism involved.
Use of Polyethylenimines for delivery of small drugs, and for the photodynamic therapy (PDT)
As polycation, Polyethylenimines were selected for its several advantageous properties (hydrophylicity, biocompatibility and thermal stability) and furosemide was chosen as a model water-insoluble drug.
The furosemide-loaded calcium alginate (ALG), calcium alginatepolyethylenimine (ALG-PEI) and alginate-coated ALG-Polyethylenimines (ALG-PEI-ALG) beads by ionotropic/polyelectrolyte complexation method to achieve controlled release of the drug were prepared.
Release of furosemide from ALG-Polyethylenimines beads was prolonged considerably compared with that from ALG beads.
Ionic interaction between alginate and Polyethylenimines led to the formation of polyelectrolyte complex membrane, the thickness of which was dependent on the conditions of Polyethylenimine treatment (Polyethylenimine concentration and exposure time).
The membrane acted as a physical barrier to drug release from ALG-Polyethylenimines beads.
The coating of ALG-Polyethylenimines beads further prolonged the release of the drug by increasing membrane thickness and reducing swelling of the beads possibly by blocking the surface pores.
Hamblin’s research group has been involved in the use of photodynamic therapy (PDT) as a possible treatment for localized infections.
They shown that covalent conjugates between Polyethylenimines and chlorin (e6) (ce6) can be used as a potent broad-spectrum antimicrobial photo sensitizers (PS) resistant to protease degradation and therefore constituting an alternative to the previously described poly-L-lysine chlorin (e6) (pL-ce6) conjugates.
Applications of Polyethylenimines:
Polyethylenimine finds many applications in products like: detergents, adhesives, water treatment agents and cosmetics.
Owing to Polyethylenimine’s ability to modify the surface of cellulose fibres, Polyethylenimine is employed as a wet-strength agent in the paper-making process.
Polyethylenimine is also used as flocculating agent with silica sols and as a chelating agent with the ability to complex metal ions such as zinc and zirconium.
There are also other highly specialized Polyethylenimine applications:
Biology:
Polyethylenimine has a number of uses in laboratory biology, especially tissue culture, but is also toxic to cells if used in excess.
Toxicity is by two different mechanisms, the disruption of the cell membrane leading to necrotic cell death (immediate) and disruption of the mitochondrial membrane after internalisation leading to apoptosis (delayed).
Attachment promoter:
Polyethylenimines are used in the cell culture of weakly anchoring cells to increase attachment.
Polyethylenimine is a cationic polymer; the negatively charged outer surfaces of cells are attracted to dishes coated in Polyethylenimine, facilitating stronger attachments between the cells and the plate.
Transfection reagent:
Polyethylenimine was the second polymeric transfection agent discovered, after poly-L-lysine.
Polyethylenimine condenses DNA into positively charged particles, which bind to anionic cell surface residues and are brought into the cell via endocytosis.
Once inside the cell, protonation of the amines results in an influx of counter-ions and a lowering of the osmotic potential.
Osmotic swelling results and bursts the vesicle releasing the polymer-DNA complex (polyplex) into the cytoplasm.
If the polyplex unpacks then the DNA is free to diffuse to the nucleus.
Permeabilization of gram negative bacteria:
Poly(ethylenimine) is also an effective permeabilizer of the outer membrane of Gram-negative bacteria.
CO2 capture:
Both linear and branched polyethylenimine have been used for CO2 capture, frequently impregnated over porous materials.
First use of Polyethylenimine polymer in CO2 capture was devoted to improve the CO2 removal in space craft applications, impregnated over a polymeric matrix.
After that, the support was changed to MCM-41, an hexagonal mesostructured silica, and large amounts of Polyethylenimine were retained in the so-called “molecular basket”.
MCM-41-PEI adsorbent materials led to higher CO2 adsorption capacities than bulk Polyethylenimine or MCM-41 material individually considered.
The authors claim that, in this case, a synergic effect takes place due to the high Polyethylenimine dispersion inside the pore structure of the material.
As a result of this improvement, further works were developed to study more in depth the behaviour of these materials.
Exhaustive works have been focused on the CO2 adsorption capacity as well as the CO2/O2 and CO2/N2 adsorption selectivity of several MCM-41-PEI materials with Polyethylenimine polymers.
Also, Polyethylenimine impregnation has been tested over different supports such as a glass fiber matrix and monoliths.
However, for an appropriate performance under real conditions in post-combustion capture (mild temperatures between 45-75 °C and the presence of moisture) Polyethylenimine is necessary to use thermally and hydrothermally stable silica materials, such as SBA-15, which also presents an hexagonal mesostructure.
Moisture and real world conditions have also been tested when using PEI-impregnated materials to adsorb CO2 from the air.
A detailed comparison among Polyethylenimine and other amino-containing molecules showed an excellent performance of PEI-containing samples with cycles.
Also, only a slight decrease was registered in their CO2 uptake when increasing the temperature from 25 to 100 °C, demonstrating a high contribution of chemisorption to the adsorption capacity of these solids.
For the same reason, the adsorption capacity under diluted CO2 was up to 90% of the value under pure CO2 and also, a high unwanted selectivity towards SO2 was observed.
Lately, many efforts have been made in order to improve Polyethylenimine diffusion within the porous structure of the support used.
A better dispersion of Polyethylenimine and a higher CO2 efficiency (CO2/NH molar ratio) were achieved by impregnating a template-occluded PE-MCM-41 material rather than perfect cylindrical pores of a calcined material, following a previously described route.
The combined use of organosilanes such as aminopropyl-trimethoxysilane, AP, and Polyethylenimine has also been studied.
The first approach used a combination of them to impregnate porous supports, achieving faster CO2-adsorption kinetics and higher stability during reutilization cycles, but no higher efficiencies.
A novel method is the so-called “double-functionalization”.
Polyethylenimine is based on the impregnation of materials previously functionalized by grafting (covalent bonding of organosilanes).
Amino groups incorporated by both paths have shown synergic effects, achieving high CO2 uptakes up to 235 mg CO2/g (5.34 mmol CO2/g).
CO2 adsorption kinetics were also studied for these materials, showing similar adsorption rates as impregnated solids.
This is an interesting finding, taking into account the smaller pore volume available in double-functionalized materials.
Thus, Polyethylenimine can be also concluded that their higher CO2 uptake and efficiency compared to impregnated solids can be ascribed to a synergic effect of the amino groups incorporated by two methods (grafting and impregnation) rather than to a faster adsorption kinetics.
Low work function modifier for electronics:
Poly(ethylenimine) and poly(ethylenimine) ethoxylated (PEIE) have been shown as effective low-work function modifiers for organic electronics by Zhou and Kippelen et al.
Polyethylenimine could universally reduce the work function of metals, metal oxides, conducting polymers and graphene, and so on.
Polyethylenimine is very important that low-work function solution-processed conducting polymer could be produced by the PEI or PEIE modification.
Based on this discovery, the polymers have been widely used for organic solar cells, organic light-emitting diodes, organic field-effect transistors, perovskite solar cells, perovskite light-emitting diodes, quantum-dot solar cells and light-emitting diodes etc.
Use in delivery of HIV-gene therapies:
Polyethylenimine, a cationic polymer, has been widely studied and shown great promise as an efficient gene delivery vehicle.
Likewise, the HIV-1 Tat peptide, a cell-permeable peptide, has been successfully used for intracellular gene delivery.
Features and Benefits of Polyethylenimines:
Primary and secondary amine groups of Polyethylenimine can efficiently bind to drugs, nucleic acids, and other functional moieties.
Branched Polyethylenimine has better complexation andbuffering capacity.
Polyethylenimines are one of the most widely used synthetic polycations in various applications because of its chemical functionality arising from the presence of cationic primary (25%), secondary (50%), and tertiary amines (25%).
Polyethylenimines are formed by the linking of iminoethylene units and can have linear, branched, comb, network, and dendrimer architectures depending upon its synthesis and modification methods, which greatly influences Polyethylenimine’s properties, both physical and chemical.
Furthermore, these synthetic approaches enable Polyethylenimines to be available in a wide range of molecular weights.
At room temperature, branched Polyethylenimines are a highly viscous liquid while linear Polyethylenimine (LPEI) is a solid.
Polyethylenimines have several attractive features for its use in widespread applications, such as low toxicity, ease of separation and recycling, and (last but not least) Polyethylenimine being odorless.
In addition to these attractive features, there is a distinct feature of Polyethylenimines which places Polyethylenimine ahead of other polyions (e.g. polyallylamine or chitosan) when it comes to loading, and which justifies its widespread use in fields as varied as detergents, adhesives, water treatment, cosmetics, carbon dioxide capture, as a DNA transfection agent, and in drug delivery despite being a weak polymeric base with pKa values between 7.9 and 9.6, Polyethylenimine possesses a high ionic charge density, which in practical terms translates into being a more cost-effective material.
This derives from the possibility of either reaching the same loadings with reduced amounts of the polymer (which would colloquially mean “getting a bigger bang for the buck”) or reaching loadings that are beyond the reach of the aforementioned examples while avoiding enzyme agglomeration thanks to Polyethylenimine’s multi-branched network.
Properties of Polyethylenimines:
The linear Polyethylenimine is a semi-crystalline solid at room temperature while branched Polyethylenimine is a fully amorphous polymer existing as a liquid at all molecular weights.
Linear Polyethylenimine is soluble in hot water, at low pH, in methanol, ethanol, or chloroform.
Polyethylenimine is insoluble in cold water, benzene, ethyl ether, and acetone.
Linear Polyethylenimine has a melting point of around 67 °C.
Both linear and branched Polyethylenimine can be stored at room temperature.
Linear Polyethylenimine is able to form cryogels upon freezing and subsequent thawing of its aqueous solutions.
Other Properties:
Polyethylenimines are a colorless and highly viscous liquid.
Polyethylenimines are soluble in water, ethanol, hygroscopic, insoluble in benzene and acetone.
Polyethylenimines will produce precipitation when it meets sulfuric acid with pH below 2.4.
The aqueous solution of Polyethylenimines is positively charged, and formaldehyde is added to produce condensation.
Polyethylenimines are colorless or light yellow viscous liquid, hygroscopic, soluble in water, ethanol, insoluble in benzene, acetone.
Precipitation occurs when Polyethylenimine meets sulfuric acid with a pH of less than 2.4.
The aqueous solution was positive and formaldehyde was added to produce coagulation.
Gelation occurs in the presence of an acid.
Commercially available products are generally aqueous solutions having a concentration of 20% to 50%.
Synthesis of Polyethylenimines:
Branched Polyethylenimine can be synthesized by the ring opening polymerization of aziridine.
Depending on the reaction conditions different degree of branching can be achieved.
Linear Polyethylenimine is available by post-modification of other polymers like poly(2-oxazolines) or N-substituted polyaziridines.
Linear Polyethylenimine was synthesised by the hydrolysis of poly(2-ethyl-2-oxazoline) and sold as jetPEI.
The current generation in-vivo-jetPEI uses bespoke poly(2-ethyl-2-oxazoline) polymers as precursors.
Handling And Storage of Polyethylenimines:
Precautions for safe handling:
Advice on safe handling:
Handle under argon.
Hygiene measures:
Immediately change contaminated clothing.
Apply preventive skin protection. Wash hands and face after working with substance.
Conditions for safe storage, including any incompatibilities:
Storage conditions:
Tightly closed.
Store under argon.
Stability And Reactivity of Polyethylenimines:
Reactivity:
No data available
Chemical stability:
Polyethylenimine is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions:
No data available
Conditions to avoid:
no information available
First Aid Measures of Polyethylenimines:
General advice
Show this material safety data sheet to the doctor in attendance.
If inhaled:
After inhalation:
Fresh air.
In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.
In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
Indication of any immediate medical attention and special treatment needed:
No data available
Fire Fighting Measures of Polyethylenimines:
Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
Unsuitable extinguishing media:
For Polyethylenimine no limitations of extinguishing agents are given.
Further information:
Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating surface water or the ground water system.
Accidental Release Measures of Polyethylenimines:
Environmental precautions:
Do not let product enter drains.
Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent and neutralising material.
Dispose of properly.
Clean up affected area.
Exposure Controls/Personal Protection of Polyethylenimines:
Personal protective equipment:
Eye/face protection:
Use equipment for eye protection.
Safety glasses
Skin protection:
required
Body Protection:
protective clothing
Respiratory protection:
Recommended Filter type:
Filter type ABEK
Control of environmental exposure:
Do not let product enter drains.
Identifiers of Polyethylenimines:
Chemical formula: (C2H5N)n, linear form
Molar mass: 43.04 (repeat unit), mass of polymer variable
Density: 1.030 g/mL at 25 °C
Boiling Point: 250 °C(lit.)
Flash Point: >230 ºF
Melting Point: 59-60 °C
Refractive index: n20D 1.5290
CAS No.: 9002-98-6
Molecular Formula: (C2H5N)x
InChIKeys: InChIKey=NOWKCMXCCJGMRR-UHFFFAOYSA-N
Molecular Weight: 43.069
Exact Mass: 43.04220
Boiling Point: 250 °C(lit.)
Molecular Weight: 43.06780
Flash Point: >230 °F
Appearance: N/A
CAS: 9002-98-6
EINECS: 618-346-1
InChI: InChI=1/C2H5N/c1-2-3-1/h3H,1-2H2
Molecular Formula: C2H5N
Molar Mass: 43.07
Density: 1.030 g/mL at 25°C
Melting Point: 59-60°C
Boiling Point: 250°C (lit.)
Flash Point: >230°F
Water Solubility: Soluble in water.
Formula: (C2H5N)x
No. CAS: 9002-98-6
Appearance: Liquid
Color: Colorless to light yellow
SMILES: NCCN(CCN)CCN(CCCNCN)CCN(CCNCCN)CCNCCN(CCN)CCN.[n]
Appearance (Form): Viscous Liquid
Refractive index: n20/D 1.5290
Boiling point: 250 °C(lit.)
Density: 1.030 g/mL at 25 °C
Impurities: ≤1% water
CBNumber: CB9162514
Molecular Formula:C2H5N
Molecular Weight:43.07
MDL Number:MFCD00803910
MOL File:9002-98-6.mol
Melting point: 59-60°C
Boiling point: 250 °C(lit.)
Density: 1.030 g/mL at 25 °C
Properties of Polyethylenimines:
Chemical formula: (C2H5N)n, linear form
Molar mass: 43.04 (repeat unit), mass of polymer variable
Melting Point: 59-60°C
Boiling Point: 250 °C(lit.)
Flash Point: >230 °F
Molecular Formula: C2H5N
Molecular Weight: 43.06780
Density: 1.030 g/mL at 25 °C
Physical state: viscous
Color: colorless
Odor: No data available
Melting point/freezing point
Melting point/range: 54 – 59 °C
Initial boiling point and boiling range: 250 °C – lit.
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: > 110 °C – closed cup
Autoignition temperature: > 200 °C
Decomposition temperature: > 250 °C
pH: 11 – DIN 19268
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: 15.000 mPa.s at 50 °C
Water solubility soluble
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: 1,030 g/cm3 at 25 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
vapor pressure: 9 mmHg ( 20 °C)
refractive index: n20/D 1.5290
Flash point: >230 °F
storage temp.: 2-8°C
solubility: DMSO (Sparingly)
form: Liquid
color: Pale yellow
Specific Gravity: 1.045 (20/4℃)
PH: pH(50g/l, 25℃) : 10～12
Water Solubility: Soluble in water.
Sensitive: Hygroscopic
InChI: InChI=1S/C2H5N/c1-2-3-1/h3H,1-2H2
InChIKey: NOWKCMXCCJGMRR-UHFFFAOYSA-N
SMILES: C1NC1
LogP: -0.969 (est)