PVP K-30 (POLYVINYLPYRROLIDONE)

CAS No.: 9003-39-8

EC No.: 618-363-4

Synonyms:

PVP K-30; PVP K 30; pvpK 30; PVPK30; PVP, K, 30; pvp, k, 30; Polyvinylpyrrolidone; Poly, vinyl, pyrro, lidone; pvpk30; PVPK, 30; Poly(vinylpolypyrrolidone); Polyvinylpyrrolidone and Vinylpyrrolidone Copolymers (PVP); Hydrophilic Polymers; Hydrophobic Polymers; Materials Science; Poly(vinylpyrrolidinone) (PVP); Poly(vinylpyrrolidone); Poly(vinylpyrrolidone) (PVP) and Copolymers; Polymer Science, Polymers, Vinylpyridine and Vinypyrrolidone Polymers; Plasdone, PVP, Polyvidone, Povidone; 2-Pyrrolidinone, 1-ethenyl-, homopolymer (9003-39-8); PVP, Povidone; PVPP, Crospovidone, Polyvidone; PVP K-30; PVP K 30; PVP K-30; PVP K 30; PVP K-30; PVP K 30; PNVP; Poly[1-(2-oxo-1-pyrrolidinyl)ethylen]; 1-Ethenyl-2-pyrrolidon homopolymer; 1-Vinyl-2-pyrrolidinon-Polymere; k25; k60; POP; PVP; k115; pvp2; pvp3; pvp4; pvp5; pvp6; Kollidon 25; Homopolymer of Vinylpyrrolidone; Polyvinylpyrrolidone; 1-Ethenyl-2-pyrrolidinone homopolymer; 1-Ethenyl-2-pyrrolidinone polymers; 1-Ethenyl-2-pyrrolidinone, homopolymer; 1-Vinyl-2-pyrrolidinone homopolymer; 1-Vinyl-2-pyrrolidinone polymer; PVP K-30; PVP K 30; PVP K-30; PVP K 30; PVP K-30; PVP K 30; 1-Vinyl-2-pyrrolidone polymer; 143 RP; 2-Pyrrolidinone, 1-ethenyl, homopolymer; 2-Pyrrolidinone, 1-vinyl-, polymers; 2-Pyrrolidinone, 1-vinyl-, polymers, compd. with aluminum acetate; Agent AT 717; alpha-Hydro-omega-(p-iodobenzyl)poly(1-(2-oxo-1-pyrrolidinyl)ethylene)-(sup 131)I; alpha-Hydro-omega-(p-iodobenzyl)poly(1-(2-oxo-1-pyrrolidinyl)ethylene)-(sup 131)I.; (A small part of the iodine is the radioactive isotope, (sup 131)I.); Antaron P 804; AT 717; Caswell No. 681; CCRIS 3611; Crospovidone; Crospovidonum; PVP K-30; PVP K 30; PVP K-30; PVP K 30; PVP K-30; PVP K 30; Crospovidonum, [INN-Latin]; EPA Pesticide Chemical Code 079033; 1-vinylpyrrolidin-2-one homopolymer; Plasdone K29-32; Plasdone K29/32; Polyvinylpyrrolidone K 30; Polyvinylpyrrolidone K-29/32; Polyvinylpyrrolidone K30; Povidone K29-32; Povidone K29/32; PVP K-30; PVP K-30; PVP-K 30; Ganex P 804; Ganex p-804; Hemodesis; Hemodez; PVP K-30; PVP K 30; PVP K-30; PVP K 30; PVP K-30; PVP K 30; HSDB 205; K 115 (polyamide); K 115 (VAN); K 15; K 25 (polymer); K 25 (VAN); K 30 (polymer); K 30 (VAN); K 60 (polymer); K 60 (VAN); K 90; Peviston; Plasdone; Plasdone 4; Plasdone K 29-32; Plasdone K-26/28; Plasdone No. 4; N-Vinyl-2-pyrrolidone polymer; N-Vinylbutyrolactam polymer; N-Vinylpyrrolidinone polymer; N-Vinylpyrrolidone polymer; PVP K-30; PVP K 30; PVP K-30; PVP K 30; PVP K-30; PVP K 30; Plasdone XL; Plasmosan; Polividona; Polividona [INN-Spanish]; Polividone; Polividone [DCIT]; Poly(1-(2-oxo-1-pyrrolidinyl)-1,2-ethanediyl), alpha-hydro-omega-((4-(iodo-(sup 131)I)phenyl)methyl)-; Poly(1-(2-oxo-1-pyrrolidinyl)ethylene); Poly(1-ethenyl-2-pyrrolidinone); Poly(1-vinyl-2-pyrrolidinone); Poly(1-vinyl-2-pyrrolidinone) homopolymer; Poly(1-vinyl-2-pyrrolidinone) Hueper’s Polymer No.1; Poly(1-vinyl-2-pyrrolidinone) Hueper’s Polymer No.2; Poly(1-vinyl-2-pyrrolidinone) Hueper’s Polymer No.3; PVP K-30; PVP K 30; PVP K-30; PVP K 30; Poly(1-vinyl-2-pyrrolidinone) Hueper’s Polymer No.4; Poly(1-vinyl-2-pyrrolidinone) Hueper’s Polymer No.5; Poly(1-vinyl-2-pyrrolidinone) Hueper’s Polymer No.6; Poly(1-vinyl-2-pyrrolidinone) Hueper’s Polymer No.7; Poly(1-vinyl-2-pyrrolidone); Poly(1-vinylpyrrolidinone); Poly(N-vinyl-2-pyrrolidinone); Poly(N-vinyl-2-pyrrolidone); Poly(N-vinylbutyrolactam); Poly(N-vinylpyrrolidinone); Poly(N-vinylpyrrolidone); Poly(vinylpyrrolidinone); PVP K-30; PVP K 30; PVP K-30; PVP K 30; PVP K-30; PVP K 30; Poly-N-vinyl pyrrolidone; Toxobin; UNII-2S780E561; UNII-333AG72FWJ; UNII-40UAA97IT9; UNII-68401960MK; UNII-6B46OH7T95; UNII-C67P1734QJ; UNII-E54VE15114; UNII-FZ989GH94E; UNII-H7AGY1OJO8; UNII-K0KQV10C35; UNII-RDH86HJV5Z; UNII-SZR7Z3Q2YH; UNII-U725QWY32X; Vinisil; Vinylpyrrolidinone polymer; Vinylpyrrolidone polymer; polivinilpirolidon; PVP K-30; PVP K 30; PVP K-30; PVP K 30; Poli (vinylpolypyrrolidone); Polivinilpirolidon ve Vinilpirolidon Kopolimerleri (PVP); Hidrofilik Polimerler; Hidrofobik Polimerler; Malzeme Bilimi; Poli (vinilpirolidinon) (PVP); Poli (vinilpirolidon); Poli (vinilpirolidon) (PVP) ve Kopolimerler; Polimer Bilimi, Polimerler, Vinilpiridin ve Vinipirrolidon Polimerler; Plasdone, PVP, Polyvidone, Povidone; 2-Pirolidinon, 1-etenil-, homopolimer (9003-39-8); PVP, Povidon; PVPP, Crospovidone, Polyvidone; PNVP; Poli [1- (2-okso-1-pirrolidinil) etilen]; 1-Etenil-2-pirolidon homopolimeri; 1-vinil-2-pirrolidinon-Polymere; K25; K60; POP; PVP; k115; pvp2; pvp3; pvp4; pvp5; pvp6; Kollidon 25; Vinylpirolidonun Homopolimeri; polivinilpirolidon; 1-Etenil-2-pirolidinon homopolimeri; 1-Etenil-2-pirolidinon polimerleri; 1-Etenil-2-pirolidinon, homopolimer; 1-Vinil-2-pirolidinon homopolimeri; 1-Vinil-2-pirolidinon polimer; 1-Vinil-2-pirolidon polimer; PVP K-30; PVP K 30; PVP K-30; PVP K 30; PVP K-30; PVP K 30; 143 RP; 2-Pirolidinon, 1-etenil, homopolimer; 2-Pirolidinon, 1-vinil-, polimerler; 2-Pirolidinon, 1-vinil-, polimerler, compd. alüminyum asetat ile; Ajan 717; alfa-Hidro-omega- (p-iyodobenzil) poli (1- (2-okso-1-pirolidinil) etilen) – (sup 131) I; alfa-Hidro-omega- (p-iyodobenzil) poli (1- (2-okso-1-pirolidinil) etilen) – (sup 131) I; (yotun küçük bir ksm, radyoaktif izotoptur, (sup 131) I); Antaron P 804; AT 717; Caswell No. 681; CCRIS 3611; Krospovidon; Crospovidonum; Crospovidonum, [INN-Latin]; PVP K-30; PVP K 30; PVP K-30; PVP K 30; EPA Pestisit Kimyasal Kodu 079033; 1-vinilpirolidin-2-on homopolimer; Plasdone K29-32; Plasdone K29 / 32; Polivinilpirolidon K 30; Polivinilpirolidon K-29/32; Polivinilpirolidon K30; Povidone K29-32; Povidone K29 / 32; PVP K-30; PVP K-30; PVP-K30; Ganex P 804; Ganex p-804; Hemodesis; Hemodez; HSDB 205; K 115 (poliamid); K 115 (VAN); K 15; K25 (polimer); K25 (VAN); K30 (polimer); K30 (VAN); K60 (polimer); K 60 (VAN); K 90; Peviston; Plasdone; Plazdon 4; Plasdon K 29-32; Plasdon K-26/28; 4 No’lu Plasdone; N-Vinil-2-pirolidon polimer; PVP K-30; PVP K 30; PVP K-30; PVP K 30; PVP K-30; PVP K 30; N-Vinylbutyrolaktam polimer; N-Vinilpirrolidinon polimer; N-Vinilpirrolidon polimer; Plasdone XL; Plasmosan; Polividona; Polividona [INN-spanyolca]; Polividone; Polividone [DCIT]; Poli (1- (2-okso-1-pirolidinil) -1,2-etandiil), alfa-hidro-omega – ((4- (iyodo- (sup 131) I) fenil) metil) -; Poli (1- (2-okso-1-pirrolidinil) etilen); Poli (1-etenil-2-pirrolidinon); Poli (1-vinil-2-pirrolidinon); Poli (1-vinil-2-pirolidinon) homopolimeri; Poli (1-vinil-2-pirolidinon) Hueter Polimer No.1; Poli (1-vinil-2-pirolidinon) Hueper Polimer No.2; Poli (1-vinil-2-pirolidinon) Hueper Polimer No.3; Poli (1-vinil-2-pirolidinon) Kaliper Polimer No.4; Poli (1-vinil-2-pirolidinon) Daha Dayankl Polimer No.5; Poli (1-vinil-2-pirolidinon) Kaliper Polimer No.6; Poli (1-vinil-2-pirolidinon) Daha Dayankl Polimer No. 7; PVP K-30; PVP K 30; PVP K-30; PVP K 30; PVP K-30; PVP K 30; Poli (1-vinil-2-pirolidon); Poli (1-vinilpirolidinondur); Poli (N-vinil-2-pirrolidinon); Poli (N-vinil-2-pirolidon); Poli (N-Vinilbutirolaktam); Poli (N-vinilpirolidinondur); Poli (N-vinil pirolidon); Poli (vinilpirolidinondur); Poli-N-vinil pirolidon; Toxobin; LXVIII-2S780E561; LXVIII-333AG72FWJ; LXVIII-40UAA97IT9; LXVIII-68401960MK; LXVIII-6B46OH7T95; LXVIII-C67P1734QJ; LXVIII-E54VE15114; LXVIII-FZ989GH94E; LXVIII-H7AGY1OJO8; LXVIII-K0KQV10C35; LXVIII-RDH86HJV5Z; LXVIII-SZR7Z3Q2YH; LXVIII-U725QWY32X; PVP K-30; PVP K 30; PVP K-30; PVP K 30; PVP K-30; PVP K 30; Vinisil; Vinilpirrolidinon polimer; Vinilpirrolidon polimer; pvpK 30; PVPK30; PVP, K, 30; pvp, k, 30; Polyvinylpyrrolidone; Poly, vinyl, pyrro, lidone; pvpk30; PVPK, 30; Poly(vinylpolypyrrolidone); Polyvinylpyrrolidone and Vinylpyrrolidone Copolymers (PVP); Hydrophilic Polymers; Hydrophobic Polymers; Materials Science; Poly(vinylpyrrolidinone) (PVP); Poly(vinylpyrrolidone); Poly(vinylpyrrolidone) (PVP) and Copolymers; Polymer Science, Polymers, Vinylpyridine and Vinypyrrolidone Polymers; Plasdone, PVP, Polyvidone, Povidone; 2-Pyrrolidinone, 1-ethenyl-, homopolymer (9003-39-8); PVP, Povidone; PVPP, Crospovidone, Polyvidone; PNVP; Poly[1-(2-oxo-1-pyrrolidinyl)ethylen]; 1-Ethenyl-2-pyrrolidon homopolymer; 1-Vinyl-2-pyrrolidinon-Polymere; k25; PVP K-30; PVP K 30; PVP K-30; PVP K 30; PVP K-30; PVP K 30; k60; POP; PVP; k115; pvp2; pvp3; pvp4; pvp5; pvp6; Kollidon 25; Homopolymer of Vinylpyrrolidone; Polyvinylpyrrolidone; 1-Ethenyl-2-pyrrolidinone homopolymer; 1-Ethenyl-2-pyrrolidinone polymers; 1-Ethenyl-2-pyrrolidinone, homopolymer; 1-Vinyl-2-pyrrolidinone homopolymer; PVP K-30; PVP K 30; PVP K-30; PVP K 30; 1-Vinyl-2-pyrrolidinone polymer; 1-Vinyl-2-pyrrolidone polymer; 143 RP; 2-Pyrrolidinone, 1-ethenyl, homopolymer; 2-Pyrrolidinone, 1-vinyl-, polymers; 2-Pyrrolidinone, 1-vinyl-, polymers, compd. with aluminum acetate; Agent AT 717; alpha-Hydro-omega-(p-iodobenzyl)poly(1-(2-oxo-1-pyrrolidinyl)ethylene)-(sup 131)I; PVP K-30; PVP K 30; alpha-Hydro-omega-(p-iodobenzyl)poly(1-(2-oxo-1-pyrrolidinyl)ethylene)-(sup 131)I.; (A small part of the iodine is the radioactive isotope, (sup 131)I.); Antaron P 804; AT 717; Caswell No. 681; CCRIS 3611; Crospovidone; Crospovidonum; Crospovidonum, [INN-Latin]; EPA Pesticide Chemical Code 079033; 1-vinylpyrrolidin-2-one homopolymer; Plasdone K29-32; Plasdone K29/32; Polyvinylpyrrolidone K 30; Polyvinylpyrrolidone K-29/32; PVP K-30; PVP K 30; PVP K-30; PVP K 30; Polyvinylpyrrolidone K30; Povidone K29-32; Povidone K29/32; PVP K-30; PVP K-30; PVP-K 30; Ganex P 804; Ganex p-804; Hemodesis; Hemodez; HSDB 205; K 115 (polyamide); K 115 (VAN); K 15; K 25 (polymer); K 25 (VAN); K 30 (polymer); K 30 (VAN); K 60 (polymer); K 60 (VAN); K 90; Peviston; Plasdone; Plasdone 4; Plasdone K 29-32; Plasdone K-26/28; PVP K-30; PVP K 30; PVP K-30; PVP K 30; Plasdone No. 4; N-Vinyl-2-pyrrolidone polymer; N-Vinylbutyrolactam polymer; N-Vinylpyrrolidinone polymer; N-Vinylpyrrolidone polymer; Plasdone XL; Plasmosan; Polividona; Polividona [INN-Spanish]; Polividone; Polividone [DCIT]; Poly(1-(2-oxo-1-pyrrolidinyl)-1,2-ethanediyl), alpha-hydro-omega-((4-(iodo-(sup 131)I)phenyl)methyl)-; Poly(1-(2-oxo-1-pyrrolidinyl)ethylene); Poly(1-ethenyl-2-pyrrolidinone); Poly(1-vinyl-2-pyrrolidinone); Poly(1-vinyl-2-pyrrolidinone) homopolymer; Poly(1-vinyl-2-pyrrolidinone) Hueper’s Polymer No.1; Poly(1-vinyl-2-pyrrolidinone) Hueper’s Polymer No.2; Poly(1-vinyl-2-pyrrolidinone) Hueper’s Polymer No.3; Poly(1-vinyl-2-pyrrolidinone) Hueper’s Polymer No.4; Poly(1-vinyl-2-pyrrolidinone) Hueper’s Polymer No.5; Poly(1-vinyl-2-pyrrolidinone) Hueper’s Polymer No.6; Poly(1-vinyl-2-pyrrolidinone) Hueper’s Polymer No.7; Poly(1-vinyl-2-pyrrolidone); Poly(1-vinylpyrrolidinone); PVP K-30; PVP K 30; PVP K-30; PVP K 30; Poly(N-vinyl-2-pyrrolidinone); Poly(N-vinyl-2-pyrrolidone); Poly(N-v-2-on homopolimer; Plasdone K29-32; Plasdone K29 / 32; Polivinilpirolidon K 30; Polivinilpirolidon K-29/32; Polivinilpirolidon K30; Povidone K29-32; Povidone K29 / 32; PVP K-30; PVP K-30; PVP-K30; Ganex P 804; Ganex p-804; Hemodesis; Hemodez; HSDB 205; K 115 (poliamid); K 115 (VAN); K 15; K25 (polimer); K25 (VAN); K30 (polimer); K30 (VAN); K60 (polimer); K 60 (VAN); K 90; Peviston; Plasdone; Plazdon 4; Plasdon K 29-32; Plasdon K-26/28; 4 No’lu Plasdone; N-Vinil-2-pirolidon polimer; N-Vinylbutyrolaktam polimer; N-Vinilpirrolidinon polimer; N-Vinilpirrolidon polimer; Plasdone XL; Plasmosan; Polividona; Polividona [INN-spanyolca]; Polividone; Polividone [DCIT]; Poli (1- (2-okso-1-pirolidinil) -1,2-etandiil), alfa-hidro-omega – ((4- (iyodo- (sup 131) I) fenil) metil) -; Poli (1- (2-okso-1-pirrolidinil) etilen); Poli (1-etenil-2-pirrolidinon); Poli (1-vinil-2-pirrolidinon); Poli (1-vinil-2-pirolidinon) homopolimeri; PVP K-30; PVP K 30; PVP K-30; PVP K 30; Poli (1-vinil-2-pirolidinon) Hueter Polimer No.1; Poli (1-vinil-2-pirolidinon) Hueper Polimer No.2; Poli (1-vinil-2-pirolidinon) Hueper Polimer No.3; Poli (1-vinil-2-pirolidinon) Kaliper Polimer No.4; Poli (1-vinil-2-pirolidinon) Daha Dayankl Polimer No.5; Poli (1-vinil-2-pirolidinon) Kaliper Polimer No.6; Poli (1-vinil-2-pirolidinon) Daha Dayankl Polimer No. 7; Poli (1-vinil-2-pirolidon); Poli (1-vinilpirolidinondur); Poli (N-vinil-2-pirrolidinon); Poli (N-vinil-2-pirolidon); Poli (N-Vinilbutirolaktam); Poli (N-vinilpirolidinondur); Poli (N-vinil pirolidon); Poli (vinilpirolidinondur); PVP K-30; PVP K 30; PVP K-30; PVP K 30; Poli-N-vinil pirolidon; Toxobin; LXVIII-2S780E561; LXVIII-333AG72FWJ; LXVIII-40UAA97IT9; LXVIII-68401960MK; LXVIII-6B46OH7T95; LXVIII-C67P1734QJ; LXVIII-E54VE15114; LXVIII-FZ989GH94E; LXVIII-H7AGY1OJO8; LXVIII-K0KQV10C35; LXVIII-RDH86HJV5Z; LXVIII-SZR7Z3Q2YH; LXVIII-U725QWY32X; Vinisil; Vinilpirrolidinon polimer; Vinilpirrolidon polimer; PVP K-30; PVP K 30

PVP K-30

CAS NUMBER: 9003-39-8

Linear Formula (C6H9NO)n

MDL number MFCD00149016

3D model (JSmol)

Interactive image

Abbreviations PVP, PVPP, NVP, PNVP

ChEMBL

ChEMBL1909074 ☒

ChemSpider

none

ECHA InfoCard 100.111.937

E number E1201 (additional chemicals)

SMILES

Properties

Chemical formula

(C6H9NO)n

Molar mass 2,500 – 2,500,000 g·mol-1

Appearance white to light yellow, hygroscopic, amorphous powder

Density 1.2 g/cm3

Melting point 150 to 180 °C (302 to 356 °F; 423 to 453 K) (glass temperature)

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Appearance (Colour) White to off – white

Appearance (Form) Crystalline powder

Solubility (Turbidity) 10% aq. solution Clear

Nitrogen content (N) 11.5 – 12.5%

pH (5% aq. solution) 3.0 – 7.0

Sulphated Ash max. 0.1%

Heavy Metals (Pb) max. 0.001%

K-value ~ 30

Vinyl pyrrolidone max. 0.8%

Water (KF) max. 5%

PVP K-30 is a hygroscopic, amorphous polyvinylpyrrolidone. Used in industrial, specialty and imaging coatings & paints and as a media component in digital ink jet-printing. Offers high polarity, dispersancy, hydrophilicity, adhesion, cohesivity and high glass transition temperature. PVP K-30 can be plasticized with water and most common organic plasticizers. They are linear nonionic polymers thar are soluble in water and organi solvents and are pH stable. PVP K-30 forms hard glossy transparent films and have adhesive, cohesive and dispersive properties.

PVP K-30 100% Powder is soluble in water and many organic solvents and it forms hard, transparent, glossy film. PVP is compatible with most inorganic salts and many resins. PVP stabilizes emulsions, dispersions and suspensions. While PVP is used as a film former in hair styling products, PVP can also be used as an emulsion stabilizer in creams and lotions and as a dispersant for hair colorants. Additionally, pharmaceutical grade PVP can be used in toothpastes and mouthwashes. PVP K-30 100% Powder appears as a white powder.

Applications

adhesives, ceramics, glass (fibers), coating/inks, electronic appliations, lithography and photography, fibers and textiles, membranes, metallurgy, paper, polymerizations, water and waste teratment, and hygiene.

Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone:

PVP was used as a plasma volume expander for trauma victims after the 1950s.

It is used as a binder in many pharmaceutical tablets;[2] it simply passes through the body when taken orally. (However, autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.[3] The long-term effects of crospovidone or povidone within the lung are unknown.)

PVP added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.[4] This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and Betadine, among a plethora of others.

It is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost.[5]

PVP is used in some contact lenses and their packaging solutions. It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. Examples of this use include Bausch & Lomb’s Ultra contact lenses with MoistureSeal Technology[6] and Air Optix contact lens packaging solution (as an ingredient called “copolymer 845”).[7]

PVP is used as a lubricant in some eye drops, Soothe.[8]

Technical

PVP is also used in many technical applications:

as an adhesive in glue stick and hot-melt adhesivesas a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process

as an emulsifier and disintegrant for solution polymerization to increase resolution in photoresists for cathode ray tubes (CRT)[9] in aqueous metal quenching for production of membranes, such as dialysis and water purification filters

as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating

as a thickening agent in tooth whitening gels[10]

as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation

as an additive to Doro’s RNA extraction buffer[citation needed]

as a liquid-phase dispersion enhancing agent in DOSY NMR [11]

as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly[12]

as a stabilizing agent in all inorganic solar cells[13]

Other uses

PVP binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers.

PVP is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes. It has also been used in contact lens solutions and in steel-quenching solutions.[14][15] PVP is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some.

As a food additive, PVP is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine and some beers.

In molecular biology, PVP can be used as a blocking agent during Southern blot analysis as a component of Denhardt’s buffer. It is also exceptionally good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR.

In microscopy, PVP is useful for making an aqueous mounting medium.[16]

PVP can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production.[17]

Safety

The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses,[18] and it is generally considered safe. However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP has come in contact with autologous serum (internal blood fluids) and mucous membranes. For example, a boy having an anaphylactic response after application of PVP-Iodine for treatment of impetigo was found to be allergic to the PVP component of the solution.[19] A woman, who had previously experienced urticaria (hives) from various hair products, later found to contain PVP, had an anaphylactic response after povidone-iodine solution was applied internally. She was found to be allergic to PVP.[20] In another case, a man experiencing anaphylaxis after taking acetaminophen tablets orally was found to be allergic to PVP.[21]

Povidone is commonly used in conjunction with other chemicals. Some of these, such as iodine, are blamed for allergic responses, although testing results in some patients show no signs of allergy to the suspect chemical. Allergies attributed to these other chemicals may possibly be caused by the PVP instead.[22][23]

Properties

PVP is soluble in water and other polar solvents. For example, it is soluble in various alcohols, such as methanol and ethanol,[24] as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin).[25] When dry it is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings.

A 2014 study found fluorescent properties of PVP and its oxidized hydrolyzate.[26]

History

PVP was first synthesized by Walter Reppe and a patent was filed in 1939 for one of the derivatives of acetylene chemistry. PVP was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production

Vinylpyrrolidone polymer

Polyvinylpyrrolidone is abbreviated as PVP, and is the polymer of vinylpyrrolidone. According to the different degree of polymerization, it is further classified into soluble PVP and insoluble PVPP (polyvinyl polypyrrolidone). Molecular weight of the soluble PVP is 8,000 to 10,000.The soluble PVP can be used as a precipitating agent which can be settle down through its action with polyphenols. Using this method, it is easily to have residual PVP in the alcohol. Due to the savings effect of PVP inside the human body, the World Health Organization doesn’t recommend to apply this substance. In recent years, the use of soluble PVP has been rare. Insoluble PVPP system had began to be used in the beer industry since the early 1960s. It has a relative molecule weight greater than the relative mass greater than 700,000. It is a insoluble polymer derived from the further cross-linking and polymerization of PVP and can be used as an adsorbent of polyphenols with a good efficacy.

The molecular formula of Polyvinylpyrrolidone

Polyvinylpyrrolidone PVP is one of the three major pharmaceutical new excipients and can be used as the co-solvent of tablets, granules, and injection, as the glidant of capsules, as the dispersant agent of liquid preparations and the colorant, as the stabilizer of enzyme and heat sensitive drug, as the co-precipitating agent of poorly soluble drugs, and as the detoxicant of ophthalmic drugs and lubricants.

It is industrially used as expanded polystyrene additive, as the gelling agents for suspension polymerization, stabilizer, and fiber treating agents, paper processing aids, adhesives, and thickening agents.

Polyvinylpyrrolidone PVP and its copolymers CAP is an important raw material of cosmetics, mainly used for hair retaining agent. The film it formed in the hair is elastic and shiny, and has excellent carding property as well as being free of dust. Adopting different category of resin can meet various kinds of relative humidity climatic conditions. Therefore, it is an indispensable raw material in styling hair cream, hair gel, and mousse. It can also be used for the cosmetics of skin moisturizing agents and the dispersants for grease based hair dying, also as foam stabilizers, and can improve the consistency of the shampoo.

Insoluble PVP is the stabilizer of beer and juice which can improve its transparency, color, and flavor.

Water-soluble polyamides

Polyvinyl pyrrolidone (PVP) is a water soluble polyamide. Commercially available PVP is divided into four viscosity grades according to its press K value (Fikentscher K value): K-15, K-30, K-60, K-90, with the average molecular weight being 10,000, 40000,160000, and 360000, respectively. K value or molecular weight is an important factor which decides the various properties of PVP.

Polyvinyl pyrrolidone (PVP) is dissolved in water, chlorinated solvents, alcohol, amine, nitro-paraffin and low molecular weight fatty acids, and is mutually soluble with most inorganic salts and a variety of resin; insoluble in acetone and ether. PVP used for the matrix of dropping pill matrix is odorless, tasteless, white to pale yellow waxy solid with the relative density being 1.062, and its 5% aqueous solution pH being 3 to 7. PVP is hygroscopic and of good thermal stability, and can be dissolved in various kinds of organic solvents, and has high melting point. Adding certain natural or synthetic polymers or organic compounds can effectively adjust the PVP’s hygroscopicity and softness. PVP is not prone to have chemical reaction. Under normal storage conditions, dry PVP is quite stable. PVP has excellent physical inertia and biocompatibility and has not stimulation to skin, eyes no stimulation with no allergic reactions and being non-toxic.

Because of the hydrogen bonding or complexation effect, PVP’s viscosity is increased and this further inhibits the formation and growth of crystallized nuclei of drugs, making the drug being in the amorphous state. The dropping pill whose matrix is PVP can enhance the dissolution and bioavailability of poorly soluble drugs. In general, the greater the PVP amount, the higher dissolution and solubility of drug in the medium. Susana et al have studied the dissolution of the PVP solid dispersant of the slightly soluble drug albendazole. The increased amount of PVP (k30) can increase the dissolution rate and efficiency of drug inside the solid dispersant. Teresa et al have studied the dissolution of the poorly soluble drugs, flunarizine in PVP solid dispersant and obtained similar conclusion. PVP also found that the higher the content, the more significant increase in dissolution. IR has showed that flunarizine and PVP has no chemical reaction except in some cases that a best dissolution efficacy is obtained only in certain ratio between some drugs with the PVP. Tantishaiyakul et al has found that: when the ratio of piroxicam: PVP is 1:5 and 1:6, the dissolution of the solid dispersant is the largest with a 40 times as high as that of single drug within 5min.

PVP can also be dissolved in another molten dropping pill matrix, such as polyethylene glycol (PEG), polyoxyethylene monostearate (S-40), poloxamer and stearyl acid, glyceryl monostearate, etc for making complex matrix.

The above information is edited by the Chemicalbook of Dai Xiongfeng.

Physical and chemical properties

Commonly used PVP level in the cosmetic industry is K-30. Commercialized PVP is white and free flowing powder or solids with its content in the mass fraction of 20%, 30%, 45% and 50% aqueous solution. PVP is soluble in water and is hygroscopic with a moisture equilibrium being 1/3 of the relative humidity of the environment. Similar as the protein hydration action, each monomer associates with 0.5mol water.Chart 1 and Chart 2 lists the reference quality standard of various types of polyvinylpyrrolidone PVP:

Food grade and pharmaceutical grade polyvinylpyrrolidone PVP

Chart 1: Food grade and pharmaceutical grade polyvinylpyrrolidone PVP

Cosmetics and industrial polyvinylpyrrolidone PVP (Luvikol K, BASF)

Chart 2: Cosmetics and industrial polyvinylpyrrolidone PVP (Luvikol K, BASF)

PVP is not easy to have chemical reaction. When stored at normal conditions, dry PVP is quite stable. Solution undergone mildew treatment is also stable. When heated in air to 150 °C or mixed with ammonium persulfate to heat at 90 °C for 30min, PVP will be exchanged to become a water-insoluble compound. In the presence of azo compound or a dichromate oxidizing agent, light will cause PVP solution to become gel. The co-heating of PVP solution with strong base (such as sodium silicate or trisodium phosphate) will generate precipitation. Many different compounds can generate complexes with PVP. For example, the complexes of PVP and iodine is very stable and have a good bactericidal effect and can reduce its toxicity; Adding the copolymers of the polyacrylic acid, tannic acid or methyl vinyl ether and maleic acid to the aqueous solution of PVP will generate insoluble complexes which are insoluble in water, alcohols and ketones. But when being treated with base for neutralize the poly-acid can reverse the reaction; complexation between PVP and toxins, drugs and toxic chemicals can reduce their toxicity; some kinds of dyes can also form a strong complex with PVP, which is the basis for using PVP as a dye bleaching agent.

The use of polyvinylpyrrolidone

In the early 1950s, older, with shellac and oil-based hairspray had been rapidly replaced by PVP sprays which are still widely used until now. It can form wet, transparent film on the hair which is shiny and has good lubrication effect. PVP has good compatibility with a variety of good propellant and also has corrosion resistance. It is widely used in hair styling, as the film former in combing products, as the creatinine and stabilizer of skin care lotions and creams, as the base stock material for eye and facial cosmetics and lipstick base, and also as hair dye dispersants and shampoo foam stabilizer. PVP has detoxification effect and can reduce the irritation effects of other preparation on the skin and eyes. It is also used as toothpaste detergents, gelling agents and antidotes. The main drawback of PVP is its sensitivity to moisture. However, this issue can be tackled by using its vinyl acetate copolymer in order to mitigate the effects of moisture and humidity. In addition, PVP also has wide application in the pharmaceutical, beverage and textile industries.

Rheological properties of solutions

Water and methanol is the preferred solvent of PVP. pH value has little effect on the viscosity of the aqueous solution of PVP, for example, at 25 °C, pH range: 0.1~10, aqueous solution of PVP K-30 with a mass fraction of 5% concentration has a viscosity of 2.3~2.4mPa • s; in concentrated hydrochloric acid, this is 4.96mPa • s. Effect of temperature on the viscosity of the PVP aqueous solution is also relatively not obvious. Un-cross-linked PVP solution is not particularly thixotropic unless under very high concentration and display a short relaxation time. The chart 3 below lists the viscosity of PVP K-30 in a variety of solvents.

Viscosity of PVP K-30 in various organic solvents (w %) (At room temperature)

Chart 3: Viscosity of PVP K-30 in various organic solvents (w %) (At room temperature)

Reference: Edited by Binyi Qiu, “Compendium of cosmetic chemistry and technology” Volume 1 Beijing: China Light Industry Press, 1997.

Compatibility

Polyvinylpyrrolidone is mainly used as pharmaceutical excipient, blood compatibilizer, cosmetics thickening agents, latex stabilizers, and clarifying agent of beer brewing.

Not matter whether in solution or in the form of film, PVP always has a high degree of compatibility. It has good compatibility with various kinds of inorganic salt solution, many natural and synthetic resins and other chemical compatibility. Examples of their compatibility are seen at chart 4 and Figure 5.

The compatibility of PVP and some other substances in water and ethanol

Chart 4: The compatibility of PVP and some other substances in water and ethanol The solubility and compatibility of PVP in various solvents

Chart 5: The solubility and compatibility of PVP in various solvents

Safety

PVP is physiologically inert. Acute oral toxicity of PVP: LD50 > 100g/kg. It does not irritate the skin or eyes, do not cause skin allergies. A large number of long-term toxicology studies have confirmed that polyvinylpyrrolidone (PVP) can tolerate intraperitoneal, intramuscular, intravenous administration and parenteral applications. Subacute and chronic toxicity result was negative.

Identification test

Solubility: soluble in water, ethanol and chloroform and insoluble in ether. This is measured by the OT-42 method.

Dichromate precipitation test: in 5 mL of2% sample solution, add 5 mL dilute hydrochloric acid solution (TS-117), further add 5 mL of water plus 2 mL of 10% potassium dichromate solution and 2ml. This should form an orange precipitate.

Take 75 mg of cobalt nitrate and 300 mg of ammonium thiocyanate for being dissolved in 2ml of water; add 5 mL of 2% aqueous sample solution; after the mixing, add dilute hydrochloric acid test solution (TS-117) for acidification. This should form light blue precipitate.

Take 5 mL of 2% sample solution; add 1 mL of 25% hydrochloric acid, 5 mL of 5% barium chloride and 1 mL 5% molybdenum tungsten phosphoric acid solution. This should generate a lot of white precipitate which gradually turns blue in the sunlight.

The pH value of 5% sample solution should be 3.0 to 3.7. This is measured by conventional means.

Adding a few drops of iodine test solution (TS-124) to 5 mL of 0.5% sample solution should produce a deep red color.

Take 1 g of sample, add water to 10 ml as a suspension, add 0.1 mL of iodine test solution (TS-124), after mixing by shaking for 30s, iodine test solution should fade (to distinguish polyvinylpyrrolidone due to that polyvinylpyrrolidone can form red color). Add 1 mL of starch test solution (TS-235), after shaking and mixing, there should be no blue color formed. to produce blue.

Content Analysis

Estimated from the nitrogen content according to the following index of quality.

Toxicity

ADI 0~50 (FAO/WHO, 2001)

LD50> 100g/kg (rat, oral).

ADI does not make special provision (FAO/WHO, 2001).

It is safe for food (FDA, §121.1110, §173.50, 2000).

LD50:12g/kg (mice, abdominal injection).

Limited use

GB 2760-1996: beer GMP.

Chemical Properties

It is the cross-linked homopolymer of pure vinylpyrrolidone. It is hygroscopic and free-flowing white or off-white powder. It has a slight foul smell. It is insoluble in common solvents such as water, ethanol and ether. So its molecule weight range can’t be measured. However, PVP has ability to form complex with various kinds of substances (such as “Hu” class substance which can lead to the discoloration of a variety of wines and beverages discoloration). Also it is easily to be removed after filtration because of its insolubility.

Uses

Clarifying agent; pigment stabilizer; colloidal stabilizer; It is mainly used for beer clarifying and quality stabilizing (reference amount 8~20g/100L, maintained for 24h and remove it by filtration), and can also be applied in combination with enzymes (protease) and protein adsorbents. It is also used to clarify the wine and as a stabilizer to prevent discoloration (reference amount 24~72g/100L).

Clarifying agents; stabilizers; thickeners agent; tablet fillers; dispersants; PVP of molecular weight 360,000 are often used as the clarifying agent of beer, vinegar, and grape wine.

Used as the fixing liquid for gas chromatography.

It is used as a colloidal stabilizer and clarifying agent for beer clarification. Apply proper amount according the demands of production.

It can be used for pharmacy, aquaculture, and livestock disinfectant for the sterilization of the skin and mucous.

PolyFilterTM molecule has an amide bond for absorbing the hydroxyl groups located in polyphenol molecule to form hydrogen bonds, and therefore, can be used as the stabilizer of beer, fruit wine/grape wine, and drinking wine to extend their shelf life and improve the transparency, color and taste. The products have two specifications: disposable type and regeneration type. Disposable products are suitable for application by SMEs; renewable products demand the purchase of special filtration equipment; but since it is recyclable, it is suitable for large breweries for recycle application.

In daily cosmetics, PVP and its copolymer has good dispersion property and filming property, and thus being able to be used as a setting lotion, hair spray and styling mousse, as opacifiers for hair care agents, as the stabilizer of shampoo foam, as wave styling agent and as the dispersants and affinity agents in hair dye. Adding PVP to cream, sunscreen, and hair removal agent can enhance wetting and lubricating effect. Taking advantage of the excellent properties of PVP such as surface activity, film-forming and non-irritating to the skin, no allergic reactions, etc., has broad prospects in its application in hair care and skin care products.

Production method

Its crude product comes from the polymerization of vinylpyrrolidone under basic catalyst or the existence of N, N’-divinyl amidine and further cross-inking reaction. Then use water, 5% acetic acid and 50% ethanol for reflux to until extract ≤50mg/kg (for over 3h).

The 30% to 60% aqueous solution of the purified 1-vinyl-2-pyrrolidone, in the presence of ammonia or amines and also with hydrogen peroxide as the catalyst, has cross-linking and homo-polymerization reaction at a temperature of 50 °C and subject to further purification to obtain the final product.

Chemical Properties

Hygroscopic, white or yellowish-white powder or flakes.

Chemical Properties

Povidone occurs as a fine, white to creamy-white colored, odorless or almost odorless, hygroscopic powder. Povidones with K-values equal to or lower than 30 are manufactured by spray-drying and occur as spheres. Povidone K-90 and higher K-value povidones are manufactured by drum drying and occur as plates.

Uses

suitable for gene delivery

Definition

ChEBI: A vinyl polymer composed of repeating -CH2-CR- units where R is a 2-oxopyrrolidin-1-yl group.

Production Methods

Povidone is manufactured by the Reppe process. Acetylene and formaldehyde are reacted in the presence of a highly active copper acetylide catalyst to form butynediol, which is hydrogenated to butanediol and then cyclodehydrogenated to form butyrolactone. Pyrrolidone is produced by reacting butyrolactone with ammonia. This is followed by a vinylation reaction in which pyrrolidone and acetylene are reacted under pressure. The monomer, vinylpyrrolidone, is then polymerized in the presence of a combination of catalysts to produce povidone.

brand name

Kollidon CL (BASF); Kollidon CLM (BASF); Polyplasdone (International Specialty Products);Acu-dyne;Adapettes;Adsorbobase;Adsovbotear;Agent at 717;Albigen a;Aldacol q;Amiorel eritro;Amyderm s;Andrestrac 2-10;Anexa;B 7509;Betaisod;Bridine;Clinidine;Final step;Frepp/sepp;Ganex p 804;Ga-pvp-101;Gyno-bidex;Isoplasma;Jodoplex;K 115;Kollidon 17;Kollidon 25;Kollidon 30;Kollidon 90;Kollidon ce 50/50;Kollidon k 25;Kollidon k 30;Luviskol k 17;Luviskol k 25;Luviskol k 30;Luviskol k 90;Luvisteol;Medicort;Molycu;Mundidon;Neojodin;Oftan flurekain;Peragal st;Periston-n-toxobin;Pevidine;Plasmadone;Plasmoid;Plassint;Podiodine;Polyclar at;Polyclar h;Polyclar l;Polyplasdone xl;Polyvidone-escupient;Polyvinyl pyrrolidone;Povadyne;Povidone k 29-32;Pvp 50;Pvp0;Pvp-k 15;Pvp-k 25;Pvp-k 30;Pvp-k 60;Pvp-k 90;Pvp-macrose;Pvp-macrox;Rocmuth;Sd 13;Soft-care;Tears plus;Venostasin retard;Vetedine;Yodiplexin.

World Health Organization (WHO)

Polyvidone, a polymer of vinylpyrrolidinone, is an excipient used as a suspending and dispersing agent. Injectable preparations containing polymers with a molecular weight in the order of 12,000 have caused painful local granulomatous lesions. This has led to the withdrawal of polyvidone from such preparations in some countries. Polyvidone was formerly also used as a plasma expander but, because it was sequestered within the liver and spleen, this use has been discontinued. However, it remains widely used as a vehicle for ophthalmic preparations, and as the major component of artificial tears.

General Description

White powder. Compatible with a wide range of hydrophilic and hydrophobic resins.

Air & Water Reactions

Hygroscopic. Water soluble.

Reactivity Profile

Polyvinylpyrrolidone is a polymeric material and probably has low reactivity. Polyvinylpyrrolidone reacts as a weak base.

Hazard

Questionable carcinogen.

Health Hazard

SYMPTOMS: Polyvinylpyrrolidone may cause interstitial fibrosis in the lungs. Lesions regress when patient is no longer being exposed to the compound.

Fire Hazard

Flash point data for Polyvinylpyrrolidone are not available, but Polyvinylpyrrolidone is probably non-flammable.

Pharmaceutical Applications

Although povidone is used in a variety of pharmaceutical formulations, it is primarily used in solid-dosage forms. In tableting, povidone solutions are used as binders in wet-granulation processes.Povidone is also added to powder blends in the dry form and granulated in situ by the addition of water, alcohol, or hydroalcoholic solutions. Povidone is used as a solubilizer in oral and parenteral formulations, and has been shown to enhance dissolution of poorly soluble drugs from solid-dosage forms. Povidone solutions may also be used as coating agents or as binders when coating active pharmaceutical ingredients on a support such as sugar beads.

Povidone is additionally used as a suspending, stabilizing, or viscosity-increasing agent in a number of topical and oral suspensions and solutions. The solubility of a number of poorly soluble active drugs may be increased by mixing with povidone.

Special grades of pyrogen-free povidone are available and have been used in parenteral formulations;

Contact allergens

Polyvinylpyrrolidone is widely used as is in cosmetics such as hair care products and in medical products. It acts as iodophor in iodine-polyvinylpyrrolidone. PVP is an irritant and has been claimed as the allergen in some cases of dermatitis from iodine-polyvinylpyrrolidone (although iodine is more likely the hapten). It may cause type I contact urticaria or anaphylaxis.

Safety Profile

Mtldly toxic by intraperitoneal and intravenous routes. Questionable carcinogen. When heated to decomposition it emits toxic fumes of NOx.

Safety

Povidone has been used in pharmaceutical formulations for many years, being first used in the 1940s as a plasma expander, although it has now been superseded for this purpose by dextran.

Povidone is widely used as an excipient, particularly in oral tablets and solutions. When consumed orally, povidone may be regarded as essentially nontoxic since it is not absorbed from the gastrointestinal tract or mucous membranes.Povidone additionally has no irritant effect on the skin and causes no sensitization. exists that povidone may accumulate in the organs of the body following intramuscular injection.

A temporary acceptable daily intake for povidone has been set by the WHO at up to 25 mg/kg body-weight.

(mouse, IP): 12 g/kg

storage

Povidone darkens to some extent on heating at 150°C, with a reduction in aqueous solubility. It is stable to a short cycle of heat exposure around 110-130°C; steam sterilization of an aqueous solution does not alter its properties. Aqueous solutions are susceptible to mold growth and consequently require the addition of suitable preservatives.

Povidone may be stored under ordinary conditions without undergoing decomposition or degradation. However, since the powder is hygroscopic, it should be stored in an airtight container in a cool, dry place.

Purification Methods

Purify it by dialysis, and freeze-drying. Also by precipitation from CHCl3 solution by pouring into ether. Dry it in a vacuum over P2O5. For the crosslinked polymer purification is by boiling for 10minutes in 10% HCl and then washing with glass-distilled water until free from Cl ions. Finally, Cl ions are removed more readily by neutralising with KOH and continued washing.

Incompatibilities

Povidone is compatible in solution with a wide range of inorganic salts, natural and synthetic resins, and other chemicals. It forms molecular adducts in solution with sulfathiazole, sodium salicylate, salicylic acid, phenobarbital, tannin, and other compounds; see Section 18. The efficacy of some preservatives, e.g. thimerosal, may be adversely affected by the formation of complexes with povidone.

Traditional High-Efficient Rheology Modifier Carbomer

Efficient Rheology Modifier For Home Care

Traditional Long-Flow Property Carbomer

Improved Type – Easy To Disperse Carbomer

Improved Type -Self-Wetting Carbomer

Improved Type Carbomer

Liquid Carbomer

Pharmaceutical Grade Carbomer

Home Care Carbomer

High Carlity Traditional Carbomer

Benzen Free Carbomer

Homopolymer Of Vinylpyrrolidone

NM-PVP K-30

Chemical Name: Homopolymer of Vinylpyrrolidone

CTFA Name :Polyvinylpyrrolidone

NM-PVP K-30 can dissolve in water and grain alcohol, isopropyl alcohol or chloroform, but not in acetone or diethyl ether. Have good absorption moisture, film-forming, complex ability. It is a high performance, versatile polymer widely used in pharmaceutical field, cosmetics field, beer, water treatment membrane, detergents, paints and other fields.

Application

1. Pharma application: Used as binder for tablet and pellet, dissolving assistant for injection, flowing assistant capsule, dispersant for liquid medicine and pigment, stabilizer for enzyme and heat sensitive drug.

2. Cosmetic application: Used extensively in a wide range hair care, skin care &oral care products. The products are particularly suitable for formulation where viscosity modification and film forming properties are required.

3. Tech application: As surface coating agent, dispersing agent, thickener, binder, porogen in water treatment membrane ( hollow fiber membrane, ultrafiltration membrane, nanofiltration membrane, etc.), paint, printing ink, textile, printing and drying color picture tubes.

A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander. See povidone for full details.

Indication

When in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.

Pharmacodynamics

Povidone itself has no microbicidal activity. Povidone-iodine exhibits rapid, potent, broad-spectrum antimicrobial properties 2. The clinical effectiveness of povidon-iodine on wound healing remains somewhat controversial; in few clinical studies investigating the effects of povidone-iodine on wound healing, topical administration of the complex was associated with no significant infections, but slower healing and mild to moderate discomfort on application 1.

Mechanism of action

Povidone-iodine is a water-soluble complex that mediates a bactericidal or virucidal action following the gradual liberation of free iodine from the complex at the application site to react with the pathogen 1. Please refer to the drug entry for Povidone-iodine for the full mechanism of action of the complex.

Molecular Formula: (-CH(NCH2CH2CH2CO)CH2

-)n

Molecular Weight: 35,000-51,000

CAS # : 9003-39-8

Synonym: PVP

Physical Description: White to off white powder

Solubility: Soluble in water (> 100 mg/ml), methanol, ethanol, alcohol, chloroform and glycerol, acetic acid; insoluble in dimethyl ether,

ethyl acetate, acetone, toluene, xylene, mineral oil, carbon tetrachloride. If the pH value of the solutions is higher than 6, the viscosity

will increase slightly on storage, particularly at elevated temperatures; if the pH value is less than 7 and the concentration is lower than

30%, the solutions tend to become moldy during storage.1 The addition of a preservative can prevent mold and fungus growth during

storage. Addition of large quantities of salts will precipitate the PVP from solution.

Molecular Weight 10 K 30 K 40 K 360 K

K value*: 12-18 27-33 28-32 90-103

Synonym: PVP K 15 PVP K-30 PVP K-30 PVP K 90

Bulk Density (lb/cu ft) 36 29 20 —

*K values are derived from viscosity measurements and are calculated according to Fikentscher’s formula.

Description: Typically used as thickeners, dispersing agents, detoxicant, complexing agent, lubricants and binders.

Availability:

Povidone

Povidones are available in different molecular weights. The higher the molecular weight, the greater the viscosity and consequently the adhesive strength. The K-value denotes the intrinsic viscosity of the polymer related to the molecular weight, and is derived from the relative viscosity of the aqueous solution measured at 25°C. The direct correlation between the molecular weight and properties enables the appropriate grade to be used in each formulation in the appropriate concentration in order to achieve the optimum effect.

In order to provide formulators with flexibility in the choice of wet granulation binders with good adhesive strength and ease of handing, JRS PHARMA offers 2 grades of wet binders:

PVP K-30 and VIVAPHARM® PVP K25.

PVP K-30

29.0 – 32.0

5.5 – 8.5

PVP K-30 and K25 are low viscosity wet binders with a good balance between adhesive strength and ease of handling. It is highly adhesive at low viscosity, thus offering the optimal balance between adhesive strength and ease of handling at 2-5% (PVP K-30) or 4-7% (PVP K25).

PVP K-30 and K25 has excellent solubility in water and a range of organic solvents, and is supplied as a free flowing powder with spherical particle morphology.

This ensures rapid dispersibility and ultimate flexibility in the solvent of choice. Due to its non-ionic property, it does not bear any risk of interaction with ionic APIs.

Polyvinylpyrrolidone (PVP K-30)

General PVP (PVP K-30) Properties;

Linear nonionic polymer

• High polarity/proton acceptor

• Amphiphilic

• Compatible with a variety of resins and electrolytes

• Soluble in water and polar solvents, insoluble in esters,ethers, ketones and hydrocarbons

• Unsuitable for thermoplastic processing

• Hard, glossy, transparent, oxygen permeable films which

adhere to a variety of substrates

• Hygroscopic

• Adhesive and cohesive properties

• Cross-linkable

• Physiologically inert

Commercial Types of PVP (PVP K-30)

PVP polymers are available in several viscosity grades, ranging from low to high molecular weight. This range, coupled with solubility in aqueous and organic solvent systems combined with its non-toxic character, gives PVP great flexibility. Its industrial applications include, for example, in adhesives to improve strength and toughness; in paper manufacture to increase strength and as a coating resin; and in synthetic fibers to improve dye receptivity. It is also widely employed in inks, imaging, lithography, detergents and soaps, the textile, ceramic, electrical, metallurgical industries and as a polymerization additive. PVP polymer is supplied in five viscosity grades as a powder and/or aqueous solution. Ashland also offers

pharmaceutical grades of PVP; our PlasdoneTM polymer and PolyplasdoneTM polymer products are used in the pharmaceutical industry, and our PolyclarTM stabilizers are used in the beverage industry.

Chemical and Physical Properties of Polyvinylpyrrolidone (PVP K-30)

Molecular Weight:111.144 g/mol

Odor:ODORLESS

Appearance:White powder. Compatible with a wide range of hydrophilic and hydrophobic resins.

Color: Faintly yellow solid

Melting point ~165 °C (dec.)(lit.)

Boiling Point:90-93 deg C

density :1,69 g/cm3

Water Solubility :Soluble in water.

Sensitive :Hygroscopic

Stability:Stable. Incompatible with strong oxidizing agents. Light sensitive. Hygroscopic.

Specific Gravity: 1.1 – 1.3

pH: 3.0 – 7.0 (1:20 solution)

The use of polyvinylpyrrolidone (PVP K-30)

Industrial Applications of Polyvinylpyrrolidone (PVP K-30)

Polyvinylpyrrolidone is widely used in a broad variety of industries. This is due to its unique physical and chemical properties, particularly because of its good solubility in both water and many organic solvents, its chemical stability, its affinity to complex both hydrophobic and hydrophilic substances and its nontoxic character.

Applications and specifications: Used for various applications in cosmetics. They are used in cosmetics as thickening agents, emulsifiers, lubricants and binders. It is suitable to be added to cosmetic products that increase the appearance of the cleaner, paint or skin and hair. PVP K-30 powder and PVP K 90 powder can be used in formulations for both oily and non-oil based creams. PVP K-30 acts as a stiffening agent in hair styling preparations and adjusts the consistency of shampoos, hair dyes and similar preparations. PVP K-30 powder can be added to shampoo and household detergents to protect the skin. Unlike anionic colloids, PVP K grades, such as basic dyes and cationic materials, can be combined, although PVP K-30 powder should be included in the calculations to tack paint. PVP K-30 Powder can be used in hair care preparations such as styling gels and solubilizers.

Summary of technical applications: Suspensions, dispersants and emulsions: Aqueous suspensions, emulsions and dispersions can be stabilized by adding PVP K products. They are absorbed as a thin layer on the surface of colloidal particles, which prevents them from coagulating.

Main Uses of Polyvinylpyrrolidone (PVP K-30)

• Protective Colloid and Suspending Agent

• Dye-Receptive Resin

• Binder and Stabilizer

• Adhesive

• Complexing Agent

• Physiologically Inert

•Plastics productions: In the production of solid plastic polymers, PVP K products are used as protective colloids and polymerisation stabilizers.

•Paints: K 30 and K 90 are used as protective colloids and dispersants in emulsion paints and dispersion coatings and affect the rheology of the dispersions.

Paper making: They are used in paper coating because of their rapid dissolution in water. (If it is not intended to rewet the paper in the next step). The paper retains the curl and provides a smooth, smooth surface.

•Laundry detergents

•Fiberglass

•Ceramics

•Tablet assistants: PVP K-30 is used as a binder for all of the tablets used for purposes not previously owned (such as dental cleansing tablets or paint and paint box tablets).

•Photographic films: PVP K-30 can be used in the production of photographic films as protective colloid and adhesion promoter.

•In insecticides

•Preparation of adhesive bandages: K 30 and K 90 can be used as a binder for easy to use plaster bandages. The bandage is applied as a methanoic suspension containing the PVP K-30 and K 90 additions and is subsequently dried.

Potential Health Effects of Polyvinylpyrrolidone (PVP K-30)

Inhalation: May cause irritation to the respiratory tract. Symptoms may include coughing, sore throat, labored breathing, and chest pain.

Ingestion: May cause irritation to the gastrointestinal tract. Symptoms may include nausea, vomiting and diarrhea.

Skin Contact: May cause irritation with redness and pain.

Eye Contact: May cause irritation, redness and pain.

Chronic Exposure: No information found.

PVP K-30

Tanm: Hafif karakteristik kokulu beyaz toz.

Ambalaj birimi: 90 kg PE varil.

Cas No: 9003-39-8

Kimyasal ad: Vinilprolidonun homopolimerleri (polivinilprolidon).

Spesifikasyonlar:

PVP K-30 Toz

Vinil prolidon: < 2 mg/kg

Kat içerik: 96,3 g/100 g

K deeri: 30,0

pH deeri, %10 suda: 3,4

Monomer ünitesi molekül arl: 111,14 g/mol

Sulu çözeltileri berrak ve renksiz-hafif sarms’dr. Toz ürünler, beyazdr.

Çözünürlük: Suda,etanol ve izopropanolde çözünür. Elektrolitik karaktere sahip deildir. Sulu çözeltileri, farkl suda çözünen selüloz türevlerinin çözletileriyle kartrlabilir. Onlar genelde kullanlan non-iyonik, anyonik veya katyonik ürünlerle ve poliakrilatlar, poliquatlar, tuzlar, asitler ve bazlarla kombine edilebilirler. PVP K çeitleri, nispeten yüksek miktarda tuz eklenmesiyle çözeltilerden çöktürülebilir. PVP K 90, K 17’den hissedilir derecede daha fazla çökme gösterir. PVP’nin farkl organik solventlerdeki çözünürlüü geni bir alanda farkllk gösterir. PVP K çeitleri en az % 10 PVP içeren çözeltiler verecek ekilde aadaki solventlerde çözünürler:

Alkoller: Etanol, n-propanol,izopropanol, n-butanol, 2-etil-1-hekzanol, siklohekzanol, metilsiklohekzanol, propilen glikol, 1,3-butandiol, metilizobutil karbinol, gliserol.

Esterler: etil laktat

Eter Alkolleri: Hekzaetilen glikol, dietilenglikol, monometil eter, polietilen glikol 400, etilenglikol monoetil eter, dietilen glikol, trietilenglikol

Ketonlar: siklohekzanon (starak) metil siklo hekzanon,

Asitler: Formik asit, asetik asit, propiyonik asit

Aminler: sikloheksilamin, dietanolamin, trietanol amin, etilendiamin, monoetanol amin

Depolama: 6’nn üzerindeki pH ‘a sahip sulu çözeltilerin viskositesi, artan scaklk ve uzayan depolama srasnda artar. %30’un altndaki konsantrasyonlardaki asitletirilmi çözeltiler, depolama srasnda küf geliimine eilim gösterirler.Bu polihekzametilen biguadin HCl gibi bir koruyucu eklenerek önlenebilir. OH veya NH2 gruplaryla reaksiyon veren koruyucularun kullanm önerilmez.

PVP K 80’in K deeri istisnai olarak uzun depolama srasnda düer.

Depolama ve kararllk: PVP K 17,30,80 ve 90 çözeltileri 25 oC’nin altnda açlmam orijinal ambalajnda en az 3 yl raf ömrüne sahiptir. PVP K-30, 80, 85Q ve K90 çözeltileri 20 oC’nin altnda tercihen 4 oC’de açlmam orijinal ambalajnda en az 2 yl raf ömrüne sahiptir.

Uygulamalar ve teknik özellikler: Kozmetikte çeitli uygulamalar için kullanlr. Kalnlatrc ajanlar, emülsifiyerler, yalayc ve balayclar olarak kozmetikte kullanlrlar. Temizleyici, boya veya cilt ve saç görünümünü yükselten kozmetik ürünlerine eklenmesi uygundur. PVP K-30 toz ve PVP K 90 toz yal ve yasz bazl belirli kremlerin her ikisininde formülasyonlarnda kulllanlabilir. PVP K-30 saç ekillendirici preparatlarda sertletirici ajan olarak rol oynar ve ampuanlarn, saç boyas ve benzeri preparatlarn kvamn ayarlar. PVP K-30 toz, cildi korumak amacyla ampuan ve ev deterjanlarna eklenebilir. Anyonik kolloidlerin tersine, PVP K-30 toz’un boyalar balama eiliminde olduu hesaba katlmas gerekmesine ramen, PVP K çeitleri örn;bazik boyalar ve katyonik maddelerle birletirilebilirler. PVP K-30 Toz, ekillendirici jeller ve çözeltiler gibi saç bakm preparatlarnda kullanlabilir.

Teknik uygulamalarn özeti: Süspansiyonlar, datclar ve emülsiyonlar: Sulu süspansiyon, emülsiyon ve dalmlar PVP K ürünleri eklenerek kararl hale getirilebilir. Onlar, kendilerinin koagüle olmasn engelleyen koloid partiküllerin yüzeyinde ince bir tabaka olarak emilirler.

Plastik üretimleri: Kat plastik polimerlerin üretiminde , PVP K ürünleri koruyucu kolloidler ve polimerizasyon stabilize edicileri olarak kullanlrlar.

Yaptrclar: K 90 ve K 80, sodyum stearat bazl yaptrc stiklerde kalnlatrc ve yaptrc olarak kullanlabilirler. Farkl PVP K ürünleri, istenen younlukta yaptrc stikleri vermesi amacyla harmanlanabilir. Yaptrc dalmlarda PVP K ürünleri, koruyucu kolloidler ve kalnlatrc ajanlar olarak kullanlrlar. PVP K ürünleri suda kolayca çözünebildii gibi, posta pullar, zarflar vs… için slatc reçinelerde kullanlabilir.

Boyalar: K 30 ve K 90 emülsiyon boyalar ve dispersiyon kaplamalarnda koruyucu kolloidler ve datc olarak kullanlrlar ve dalmlarn reolojisini etkilerler.

Kat yapm: Suda hzl çözünmesi nedeniyle kat kaplamada kullanlrlar. (eer bir sonraki admda kad tekrar slatmak tasarlanmyorsa).Kad kvrlmaktan alkoyar ve pürüzsüz, düzgün bir yüzey salar.

Çamar deterjanlar: Bir katk olarak, ykama svlarnn kir (leke) kapasitesini artrr. Ve boyalarn tekrar tortu brakmasn engeller. Enzimlerin üretiminde tozu bastrmak için, enzimler için bir kaplayc olarak kullanlabilirler.

Cam elyaf: K 90 elyafn yüzeyini düzeltmek için hal preparatlarnda bir komponent olarak kullanlrlar.

Bask ve dier mürekkepler: stenen viskositeyi elde etmek için kullanlabilir.

Seramikler: K 90, kolay ilenemeyen killer için bir balayc olarak kullanlabilir. Dier balayclara göre avantaj, ateleme srasnda tamamen yanmaya devam etmesi ve bu nedenle seramik kütlesini etkilememesi. Bu özellikle Na iyonlarn içermeyen elektriksel yaltkanlarn üretiminde önemlidir. PVP K 90, ayrca yanmaz pervazlarn gücünü artrr.

Tabletleme yardmclar: PVP K-30, ilaca ait olmayan (diçilie ait temizleme tabletleri veya boya ve boya kutularnn tabletleri gibi) amaçlar için kullanlan tabletlerin tamam için bir balayc olarak kullanlr.

Fotoraf filmleri: PVP K-30, koruyucu kolloid ve yapma tetikçisi olarak fotoraf filmlerinin üretiminde kullanlabilir. K 17, fotoraf kadnda bir balayc olarak kullanlr.

Böcek ilaçlarnda: K 90, böcek ilac dalmlarnda bir datc olarak kullanlr ve aktif maddenin bitkiye yapmasn iyiletirir.

Yaptrc bandajlarn hazrlanmas: K 30 ve K 90 kullanm kolay plaster bandajlar için bir balayc olarak kullanlabilir. Bandaja, PVP K-30 ve K 90 ilavesi içeren bir metanoik süspansiyon olarak uygulanr ve sonradan kurutulur.

Not: laç preparatlarnda kullanma uygun deildir.

Ek bilgi: Film yapc ve kalnlatrc olarak kullanlr.Farkl molekül arlkl vinil prolidon homopolimerleridir. Moleküler arlk PVP nin setting özelliklerini belirler. Moleküler arlk ne kadar yüksekse, setting’de o kadar büyük olur. Jel tipi uyuglamalarda Carbomer tipi kalnlatrc ve dier kart bal poliakrilatlarla uyumludur. Bitmi ürünlerde yüksek saflk istenen su bazl uygulamalarda kullanm için idealdir.Özellikle slak görünüm jelleri saç kremleri, pompal spreyler ve sv saç ekillendirme (setting) preparatlarnda normalden-sert’e kadar bir tutu salar. PVP K-30 Toz, saç bakm ürünleri (ekillendirme jel ve solüsyonlar gibi) üretiminde kullanlabilir. Saç jeli formülasyonunun yan sra, PVP K-30 düük viskositenin önem tad pompal spreylerde kullanlr. K 80 ve K 90 saç jelleri ve kremleri gibi yüksek tutulu ve yüksek viskositeli ürünler içindir.

Polivinilpirolidon (PVP K-30)

Polivinilpirolidon PVP, üç önemli farmasötik yeni eksipiyanstan biridir ve sv preparatlarn dispersan ajan ve renk verici olarak kapsüllerin kayganlatrcs olarak tabletlerin, granüllerin ve enjeksiyonun ortak çözücüsü olarak enzim stabilizatörü olarak kullanlabilir ve sya kar hassas ilac, zayf çözünür ilaçlarn birlikte çökeltici ajan olarak ve oftalmik ilaçlarn ve yalayclarn detoksifiye edicileri olarak içerir.

Süspansiyon polimerizasyonu, stabilizatör ve elyaf ileme maddeleri, kat ileme yardmclar, yaptrclar ve koyulatrma maddeleri için jelletirici ajanlar olarak endüstriyel olarak genletirilmi polistren katks olarak kullanlr.

Polivinilpirolidon PVP ve kopolimerleri CAP, saç tutma ajan için arlkl olarak kullanlan kozmetikte önemli bir hammaddedir. Saçta oluturduu film, elastik ve parlaktr ve mükemmel bir taraklama özelliine sahiptir ve tozdan arndrlmtr. Farkl reçine kategorilerini benimsemek, çeitli bal nem iklim koullarn karlayabilir. Bu nedenle, saç kremi, saç jeli ve köpük oluturmak için vazgeçilmez bir hammaddedir. Ayn zamanda cilt nemlendirici ajanlar ve ya bazl saç boyama için dispersanlar için köpük stabilizatörleri olarak da kullanlabilir ve ampuann tutarlln artrabilir. Çözünmez PVP, effafln artrabilen bira ve meyve suyunun stabilizatörüdür, renk ve lezzet.

Genel PVP (PVP K-30) Özellikleri;

Lineer noniyonik polimer

• Yüksek polarite / proton alcs

• Amfifilik

• Çeitli reçine ve elektrolitler ile uyumludur.

• Suda ve polar çözücülerde, esterlerde çözünmeyen, eterler, ketonlar ve hidrokarbonlar

• Termoplastik ileme için uygun deil

• Sert, parlak, effaf, oksijen geçiren filmler;

çeitli yüzeylere yapr

• Higroskopik

• Yapkan ve yapkan özellikler

• Çapraz balanabilir

• Fizyolojik olarak inert

Ticari PVP Türleri (PVP K-30)

PVP polimerler, düük molekül arlndan yüksek molekül arlna kadar çeitli viskozite derecelerinde mevcuttur. Bu aralk, sulu ve organik çözücü sistemlerde çözünürlük ile toksik olmayan karakteriyle birleince, PVP`ye büyük esneklik kazandrr. Endüstriyel uygulamalar arasnda örnein kuvvet ve tokluun arttrlmas için yapkanlar; Kât üretiminde mukavemeti artrmak için ve kaplama reçinesi olarak; ve sentetik elyaflarda boya duyarlln arttrr. Ayn zamanda mürekkepler, görüntüleme, litografi, deterjan ve sabunlar, tekstil, seramik, elektrik, metalürjik endüstrilerde ve polimerizasyon katk maddesi olarak yaygn ekilde kullanlmaktadr. PVP polimeri bir toz ve / veya sulu çözelti olarak be viskozite derecesinde salanr. Ashland da sunuyor

ilaç snf PVP; PlasdoneTM polimer ve PolyplasdoneTM polimer ürünleri ilaç endüstrisinde kullanlmakta ve PolyclarTM stabilizatörler içecek endüstrisinde kullanlmaktadr.

Polivinilpirolidonun (PVP K-30) Kimyasal ve Fiziksel Özellikleri

Moleküler Arlk: 111.144 g / mol

Koku: kokusuz

Görünü: Beyaz toz. Çok çeitli hidrofobik ve hidrofobik reçineler ile uyumludur.

Renk: Hafif sar kat

Erime noktas ~ 165 ° C (dec.) (Lit.)

Kaynama noktas: 90-93 derece C

younluk: 1,69 g / cm3

Suda Çözünürlük: Suda özünebilir.

Hassas: Higroskopik

Kararllk: Kararl. Güçlü oksitleyici ajanlarla uyumaz. Ik duyarl. Higroskopik.

Özgül Arlk: 1.1 – 1.3

pH: 3.0 – 7.0 (1:20 çözelti)

Polivinilpirolidon (PVP K-30)

1950`lerin banda, daha eski, elakl ve ya bazl saç spreyiyle hzla imdiye kadar yaygn olarak kullanlan PVP spreyleri getirildi. Parlak olan ve iyi bir yalama etkisi olan slak ve effaf bir film oluturabilir. PVP, iyi itici gaz çeitleriyle iyi uyumluluk gösterir ve ayrca korozyon direncine sahiptir. Saç ekillendirmesinde yaygn olarak kullanlr; tarama ürünlerinde, cilt bakm losyonlar ve kremlerin kreatinin ve dengeleyici olarak, göz ve yüz kozmetii ve ruj taban için temel stok malzemesi olarak ve ayn zamanda saç boya dispersanlar ve ampuan köpük dengeleyici. PVP`nin detoksifikasyon etkisi vardr ve dier preparatlarn cilt ve gözler üzerindeki tahri etkilerini azaltabilir. Ayrca di macunu deterjanlar, jelletirici maddeler ve panzehir olarak kullanlr. PVP`nin temel dezavantaj, neme duyarl olmasdr. Bununla birlikte, bu sorun, nem ve nem etkilerini azaltmak için vinil asetat kopolimerini kullanarak ele alnabilir. Buna ek olarak, PVP, ayn zamanda ilaç, içecek ve tekstil endüstrisinde geni bir uygulama alanna sahiptir.

Polivinilpirolidonun (PVP K-30) Endüstriyel Uygulamalar

Polivinilpirolidon, geni çapta endüstrilerde yaygn olarak kullanlmaktadr. Bunun nedeni, özellikle hem suda hem de birçok organik solventte iyi çözünürlüü, kimyasal stabilitesi, hem hidrofobik hem hidrofilik maddeler kompleksine olan afinitesi ve toksik olmayan karakteri nedeniyle esiz fiziksel ve kimyasal özelliklerinden dolaydr.

Uygulamalar ve özellikler: Kozmetikteki çeitli uygulamalar için kullanlr. Kozmetikte koyulatrma maddeleri, emülgatörler, yalayclar ve balayclar olarak kullanlrlar. Temizleyici, boya veya cilt ve saç görünümünü artran kozmetik ürünlere eklenmek uygundur. PVP K-30 tozu ve PVP K 90 tozu hem yal hem de ya bazl kremler için formülasyonlarda kullanlabilir. PVP K-30, saç ekillendirici preparatlarda sertletirici bir ajan olarak görev yapar ve ampuanlar, saç boyalar ve benzeri müstahzarlarn tutarlln ayarlar. Cildi korumak için ampuan ve evde kullanlan deterjanlara PVP K-30 tozu eklenebilir. Anyonik kolloidlerden farkl olarak bazik boyalar ve katyonik malzemeler gibi PVP K kaliteleri kombine edilebilir, ancak PVP K-30 tozu boya yaptrmak için hesaplamalara dahil edilmelidir. PVP K-30 Toz, saç ekillendirme jöleleri ve çözünürletiriciler gibi saç bakm müstahzarlarnda kullanlabilir.

Teknik uygulamalarn özeti: Süspansiyonlar, dispersanlar ve emülsiyonlar: Sulu süspansiyonlar, emülsiyonlar ve dispersiyonlar PVP K ürünleri eklenerek stabilize edilebilir. Koloidal parçacklarn yüzeyinde phtlamay önleyen ince bir katman olarak emilirler.

Polivinilpirolidonun (PVP K-30) Temel Kullanmlar

• Koruyucu Koloid ve Askdaki Ajan

• Boya Alc Reçinesi

• Balayc ve Stabilizatör

• Yapkan

• Karmaklatrc Ajan

• Fizyolojik Olarak nert

• Plastikler: Kat plastik polimerlerin üretiminde PVP K ürünleri, koruyucu kolloidler ve polimerizasyon stabilizatörleri olarak kullanlrlar.

• Boyalar: K 30 ve K 90, emülsiyon boyalarnda ve dispersiyon kaplamalarda koruyucu kolloidler ve dispersanlar olarak kullanlr ve dispersiyonlarn reolojisini etkiler.

Kat yapma: Suda hzla çözünmeleri nedeniyle kat kaplamada kullanlrlar. (Kad bir sonraki admda yeniden slatmaya yönelik deilse). Kat kvrmay korur ve pürüzsüz düz bir yüzey salar.

• Çamar deterjanlar

•Fiberglas

• Seramik

• Tablet asistanlar: PVP K-30, daha önce sahibi olmayan amaçlar için kullanlan tüm tabletlerin (di temizleme tabletleri veya boya ve boya kutusu tabletleri gibi) bir balayc olarak kullanlr.

• Fotografik filmler: PVP K-30, koruyucu kolloid ve yapma arttrc olarak fotografik filmlerin üretiminde kullanlabilir.

• Böcek ilaçlarnda

• Yapkan bandajlarn hazrlanmas: K 30 ve K 90 alç bandajlarn kullanm kolay bir cilttir. Bandaj, PVP K-30 ve K 90 ilavelerini içeren bir metanoik süspansiyon halinde uygulanr ve daha sonra kurutulur.

Polivinilpirolidonun (PVP K-30) Potansiyel Salk Etkileri

Soluma: Solunum sisteminde tahrie neden olabilir. Belirtiler öksürük, boaz ars, emzik nefes alma ve göüs ars içerebilir.

Sindirim sistemi: Gastrointestinal sistemde tahrie neden olabilir. Belirtiler bulant, kusma ve diyare içerebilir.

Deri ile temas: Kzarma ve ar ile tahrie neden olabilir.

Gözle Temas: rritasyon, kzarklk ve arya neden olabilir.

Kronik Pozlama: Bilginize ulaamad.

PVP K-30 (POLYVINYLPYRROLIDONE)

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PVP K-30 (POLYVINYLPYRROLIDONE)

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