PVP/VA COPOLYMER (PVP/VA KOPOLMER)

CAS NO: 25086-89-9

METATAGS:PVP/VA W 635; PVP-VA W 635; PVP VA W 635; PVP/VA W-635; PVP/VA W/635;PVP-VA E-335; PVP-VA E-335; PVP-VA E-635; PVP-VA E-735; PVP-VA I-335; PVP/VA 37 E; PVP/VA 37 I; PVP/VA 55 E; PVP/VA 55 I; PVP/VA 64 E; PVP/VA E 335; PVP/VA E 535; PVP/VA E 635; PVP/VA E 735; PVP/VA I-735; PVP/VA E-635; PVP/VA E-735; PVP/VA I-635; PVP/VA W-635; PVP/VA E-635; PVP/VA E-535; PVP/VA I-535; PVP/VA I-335; PVP/VA I-635;Luviskol® VA 37 E ; Luviskol® VA 37 I ; Luviskol® VA 55 I ; Luviskol® VA 64 P ; Luviskol® VA 64 W ; Luviskol® VA 73 W ; Luviskol® VA 73 E; Luviskol VA 37 E 2; Luviskol VA 37 I ; Luviskol VA 55 I ; Luviskol VA 64 P ; Luviskol VA 64 W ; Luviskol VA 73 W ; Luviskol VA 73 E ethenyl acetate;1-ethenylpyrrolidin-2-one; copovidone; Kollidon VA64; poly(V-co-V-Ac); poly(vinyl pyrrolidone-co-vinyl acetate); poli(vinil pirolidon-ko-vinil asetat); poly(vinylpyrrolidone-co-vinyl-acetate); poli(vinilpirolidon-ko-vinil-asetat); PVP VA64; PVP-VA; Poly(1-vinylpyrrolidone-co-Vinyl Acetate); 25086-89-9; PVP/VA Copolymer; Polectron 845; Luviskol VA 28I; Luviskol VA 37E; Luviskol VA 64; Kolima 10; Kolima 35; Luviskol VA 281; Gantron S 860; Luviskol VA 28 I; Luviskol VA 37 E; PVP-VA; ethenyl acetate- 1-ethenylpyrrolidin-2-one(1:1); Acetic acid vinyl ester, polymer with 1-vinyl-2-pyrrolidinone; Acetic acid ethenyl ester, polymer with 1-ethenyl-2-pyrrolidinone; Vinyl acetate-vinylpyrrolidone polymer; vinil asetat-vinilpirolidon polimer; Vinylpyrrolidone-vinyl acetate polymer; vinilpirolidon-vinil asetat polimer; Vinyl acetate-vinylpyrrolidinone polymer; Vinyl acetate-vinylpyrrolidone copolymer; Vinylpyrrolidinone-vinyl acetate polymer; Vinylpyrrolidone-vinyl acetate copolymer; N-Vinylpyrrolidone-vinyl acetate polymer; Vinyl acetate-N-vinylpyrrolidone polymer; Vinyl acetate-N-vinylpyrrolidinone polymer; Vinyl acetate-N-vinylpyrrolidone copolymer; Vinyl acetate-vinylpyrrolidinone copolymer; Vinylpyrrolidinone-vinyl acetate copolymer; Vinyl acetate-N-vinylpyrrolidinone copolymer; 1-Vinyl-2-pyrrolidone-vinyl acetate copolymer; 2-Pyrrolidinone, polymer with ethenyl acetate; Vinyl acetate-1-vinyl-2-pyrrolidinone polymer; Vinyl acetate-N-vinyl-2-pyrrolidone copolymer; Vinyl acetate-N-vinyl-2-pyrrolidinone copolymer; Ethenyl acetate, polymer with 1-ethenyl-2-pyrrolidinone; vinylpyrrolidone vinyl acetate; N-vinylpyrrolidone vinyl acetate; 1-vinylpyrrolidone vinyl acetate; 1-vinil pirolidon vinil asetat; acetic acid ethenyl ester, polymer with 1-ethenyl-2-pyrrolidinone; ethenyl acetate;1-ethenylpyrrolidin-2-one; poly(1-vinyl pyrrolidone-co-vinyl acetate); VP/VA COPOLYMER, 1-ETHENYL-2-PYRROLIDINONE, POLYMER WITH ACETIC ACID ETHENYL ESTER; 1-ETHENYL-2-PYRROLIDINONE, POLYMER WITH ETHENYL ACETATE; ACETIC ACID ETHENYL ESTER, POLYMER WITH 1ETHENYL2PYRROLIDINONE; ACETIC ACID, ETHENYL ESTER, POLYMER WITH 1-ETHENYL-2-PYRROLIDINONE; ETHENYL ACETATE, POLYMER WITH 1-ETHENYL-2-PYRROLIDINONE; ETHENYL ESTER POLYMER WITH 1-ETHENYL-2-PYRROLIDINONE ACETIC ACID; POLYMER WITH 1-ETHENYL-2-PYRROLIDINONE ACETIC ACID, ETHENYL ESTER; POLYMER WITH ACETIC ACID ETHENYL ESTER 1-ETHENYL-2-PYRROLIDINONE; POLYMER WITH ETHENYL ACETATE 1-ETHENYL-2-PYRROLIDINONE; PVP/ VA COPOLYMER; PVP/VA COPOLYMER; 25086-89-9; PVP/VA Copolymer; Polectron 845; Luviskol VA 28I; Luviskol VA 37E; Luviskol VA 64; Kolima 10; Kolima 35; Gantron S 860; Poly(1-vinylpyrrolidone-co-Vinyl Acetate); PVP-VA; Ganex E 535; GAF-S 630; Vinyl acetate-vinylpyrrolidone polymer; Vinylpyrrolidone-vinyl acetate polymer; Luviskol VA 281; Vinyl acetate-vinylpyrrolidinone polymer; Vinyl acetate-vinylpyrrolidone copolymer; Vinylpyrrolidinone-vinyl acetate polymer; Vinylpyrrolidone-vinyl acetate copolymer; Luviskol VA 28 I; Luviskol VA 37 E; N-Vinylpyrrolidone-vinyl acetate polymer; Vinyl acetate-N-vinylpyrrolidone polymer; Vinyl acetate-vinylpyrrolidinone copolymer; Vinylpyrrolidinone-vinyl acetate copolymer; Vinyl acetate-N-vinylpyrrolidinone polymer; Vinyl acetate-N-vinylpyrrolidone copolymer; Acetic acid vinyl ester, polymer with 1-vinyl-2-pyrrolidinone; Acetic acid ethenyl ester, polymer with 1-ethenyl-2-pyrrolidinone; Vinyl acetate-N-vinylpyrrolidinone copolymer; E 535; I 535; I 635; I 735; S 630; 1-Vinyl-2-pyrrolidone-vinyl acetate copolymer; Vinyl acetate-1-vinyl-2-pyrrolidinone polymer; Vinyl acetate-N-vinyl-2-pyrrolidone copolymer; Vinyl acetate-N-vinyl-2-pyrrolidinone copolymer
ethenyl acetate- 1-ethenylpyrrolidin-2-one(1:1); Ethenyl acetate, polymer with 1-ethenyl-2-pyrrolidinone; MFCD00134018; 2-Pyrrolidinone, polymer with ethenyl acetate; AC1L6PLN; AC1Q5XA0; SCHEMBL29127; vinylpyrrolidone vinyl acetate; N-vinylpyrrolidone vinyl acetate; 1-vinylpyrrolidone vinyl acetate

What is PVP/VA Copolymer?
PVP/VA Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor. So it is very common in most Hairsprays but also found in gel’s, wax’s, pomades and styling creams. It is a synthetic ingredient that is derived from petroleum.

PVP (also known as Polyvinylpyrrolidone) was the main ingredient in the first really successful hairsprays in the early 1950s. This polymer worked as a hairspray because it was soluble in water. This meant it could be rinsed out when you wash your hair. PVP tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties.

This was fixed with the help of another polymer, a silicone called polydimethylsiloxane. To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the first place. When you spray it on, the polyvinylpyrrolidone forms a thin coating on the hair. This coating is stiff and keeps the hair from moving around. (See image below)

Unfortunately no one was aware of the dangers that came with this Polymer. If particles of PVP/VA Copolymer are inhaled, it can cause damage to the lungs in sensitive individuals. It can be considered toxic, since particles may contribute to foreign bodies in the lungs of people. Up until a few years ago, this ingredient was considered safe to use however now it is definitely an ingredient that is better to avoid.

Here at we do not use this ingredient in ANY of our products and especially not in our Hairspray. Our Grapefruit and Lemon Grass Hairspray is not only kind to you but is also kind to the environment by not having an aerosol and instead having an environmentally friendly trigger spray. This beautiful product contains a natural UV protector and hold factor which means no petro-chemicals, plastics or polymers. This gentle formula also means no more eye and scalp irritations.
Ashland offers formulators a series of vinylpyrrolidone/vinyl acetate copolymers. Members of the PVP/VA copolymer series serve as primary film formers in a variety of products demanding different degrees of water resistance. These copolymers feature specific affinity for hair, skin and smooth surfaces such as wood, glass, paper, and metal, yet do not require solvents for removal.
The advantages of using PVP/VA copolymers as film formers are:
• film flexibility
• good adhesion
• water remoistenability
• hardness

These properties make PVP/VA copolymers suitable for a variety of industrial, personal care, and pharmaceutical products. The major industrial applications are in hot melt adhesives, photoresist binders and coatings for inkjet media paper, plastic film and other substrates.

• Linear, random copolymers
• Increasing vinyl acetate content – increasing hydrophobicity, decreasing hygroscopicity, decreasing Tg
• Hydrophilic, transparent, flexible thermoplastic, oxygen permeable films which adhere to glass, plastics and metals
• Soluble in alcohols, esters, and ketones, insoluble in ethers and aliphatic hydrocarbons. Soluble in water when VP content greater than 50%
• Adhesive and cohesive properties
• E = ethanol (EtOH), I = isopropanol, W = water, S = solid

The PVP/VA E and I copolymer Series
To fit many application areas, the E and I series of PVP/VA copolymers are available as 50% solutions in ethanol and in isopropanol2, respectively. There are four distinct copolymers in the E group: E- 335, E-535, E-635, E-735, and three in the I group: 1-335, 1-535, 1-735. Each differs in monomer ratio and, therefore, in properties – water sensitivity, viscosity, softening point, etc.
This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility, and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios.

The PVP/VA S copolymer
PVP/VA S-630 copolymer, a white, odorless powder, is also available at a 60/40 VP/VA weight ratio. It is a high molecular weight, solvent and water soluble copolymer exhibiting a minimum critical solution temperature of approximately 70°C. Films cast from solutions are glossy, translucent and rewettable by water.

The PVP/VA W copolymers S
PVP/VA W-735 copolymer is a 70/30 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP/VA
W-635 copolymer is a 60/40 copolymer also supplied as a 50% aqueous solution.

VA (vinyl acetate) is a more hydrophobic molecule than VP (vinylpyrrolidone). Thus increasing VA content of the copolymer causes an increase in hydrophobicity and consequently a decrease in water solubility and hygroscopicity relative to the VP homopolymer.

Plasticizers and Polymers: Most PVP/VA copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing.
Hygroscopicity of Films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP/VA E-735 copolymer, PVP/VA E-535 copolymer and PVP/VA E- 335 copolymer. In general, PVP/VA copolymer is less hygroscopic than PVP.
PVP/VA copolymers are widely used for their excellent film forming properties in the following applications and markets:
• Coatings on paper, film, other substrates
• Water remoistenable adhesives
• Water soluble adhesives
• Decorative and protective coatings
• Photoresist/solder mask binders
• Bioadhesives
• Protective masks
In hot melt adhesives, PVP/VA copolymers are used in a variety of water remoistenable or water removable adhesives as listed
below. Here they offer the formulators performance advantages in film flexibility, adhesiveness and water remoistenability.
PVP/VA copolymers are also used in coatings for ink-jet media including paper, plastic films and other substrates to enhance dye receptivity. PVP/VA S-630 copolymer is used as a binder to allow the aqueous processing of photoresists.

Storage and handling
PVP/VA copolymers are stable for at least one year under normal conditions of storage but strict precautions should be taken to avoid moisture pickup. The E and I series have flash points in
the range of 50-55°F (10-13°C) and are classified as flammable (DOT Flammable) materials. For safety reasons and to prevent moisture pickup due to drum breathing with changes in temperature, store in a dry place below 100°F (38°C) and repack or use in explosion- proof facilities.

PVP/VA polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals.

Polyvinylpyrrolidone/vinyl acetate (PVP/VA) resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone.

PVP/VA copolymers are available as white powders or clear solutions in ethanol, isopropanol and water. Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol. The PVP/VA copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions.

The PVP/VA E- and I-series
To fit more application areas, the E- and I-series of PVP/VA copolymers are available as 50% solutions in ethanol and in isopropanol**, respectively. There are four distinct copolymers in the E group: E-335, E-535, E-635, E-735, and three in the I group: I-335, I-535, I-735. Each differs in monomer ratio, and therefore in properties – water sensitivity, viscosity, softening point, etc. This affords formulators considerable flexibility in creating new products for specific applications. The transparent films formed by all of these copolymers are characterized by adhesion, luster, hardness and water rewettability. Good compatibility with many modifiers and plasticizers permits wide freedom in formulation and broadens the range of hygroscopicity, film flexibility and abrasion resistance. Unmodified copolymers having the lower ratios of vinylpyrrolidone to vinyl acetate exhibit more moisture resistance than products with high ratios of VP to VA.

The PVP/VA W copolymers
PVP/VA W-735 is a 70/30 copolymer of PVP and vinyl acetate supplied as a 50% solution in water. PVP/VA W-635 is a 60/40 copolymer also supplied as a 50% aqueous solution. They are ideal nonionic fixative resins for alcohol-free mousses and gels. They offer formulators outstanding curl and style retention properties without build-up, flaking or dulling of hair.

Plasticizers and polymers: Most PVP/VA copolymers are compatible with a variety of nonionic and cationic polymers. Compatibility with anionic copolymers can be achieved through neutralization prior to mixing.
Hygroscopicity of films: The inherent water sensitivity of PVP/ VA copolymer films varies with the monomer ratio. Typical data are shown below for PVP/VA E-735, PVP/VA E-535 and PVP/VA E-335. In general, PVP/VA is less hygroscopic than PVP.

Industrial: In hot melt adhesives, PVP/VA copolymers are used in a variety of water
remoistenable or water removable adhesives as listed below. Here they offer the
formulator performance advantages in film flexibility, adhesiveness and water
remoistenability.
Water Remoistenable Adhesives PVP/VA Type
• Solvent-based formulations E- and I-series
• Hot melt S-630
• Hot melt, pressure sensitive, repulpable S-630

Toxicity data
Members of the PVP/VA copolymer family have been well studied in numerous
acute, sub-chronic and chronic toxicity studies in animals, as well as in human skin
clinical testing. Results indicate that these copolymers demonstrate a low order of
acute oral toxicity and are neither primary dermal irritants nor sensitizing agents.
Primary eye irritation studies on the copolymers in alcohol demonstrate minimal
to severe irritation in the rabbit due to the alcohol. Chronic studies demonstrate
no adverse effects following both oral administration in the mouse and rat and
inhalation in the rabbit and hamster.

Abstract
In this study, the influence of copolymer composition on drug-polymer solubility was investigated. The solubility of the model drug celecoxib (CCX) in various polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer compositions (70/30, 60/40, 50/50 and 30/70 w/w) and the pure homopolymers polyvinylpyrrolidone (PVP) and polyvinyl acetate (PVA) was predicted at 25 °C using a thermal analysis method based on the recrystallization of a supersaturated amorphous dispersion (recrystallization method). These solubilities were compared with a prediction based on the solubility of CCX in the liquid monomeric precursors of PVP/VA, N-vinylpyrrolidone (NVP) and vinyl acetate (VA), using the Flory-Huggins lattice theory (liquid monomer solubility approach).

The solubilities predicted from the liquid monomer solubility approach increased linearly with increasing VP/VA ratio from 0.03-0.60 w/w. Even though the solubilities predicted from the recrystallization method also increased with increasing VP/VA ratio from 0.02-0.40 w/w, the predicted solubility seemed to approach a plateau at high VP/VA ratios.

Increasing positive deviations from the Gordon-Taylor equation with increasing VP/VA ratio indicated strong interactions between CCX and the VP repeat unit, which was in accordance with the relatively high solubilities predicted using both methods.
As the solubility plateau may be a consequence of steric hindrance caused by the size differences between CCX and the VP repeat units, it is likely that a CCX molecule interacting with a VP repeat unit hinders another CCX molecule from binding to the neighboring repeat units in the polymer chain.

Therefore, it is possible that replacing these neighboring hygroscopic VP repeat units with hydrophobic VA repeat units, could increase the physical stability of an amorphous solid dispersion without compromising the drug-polymer solubility. This knowledge could be used advantageously in future development of amorphous drug delivery systems as copolymers could be customized to provide optimal drug-polymer solubility and physical stability.

PVP/VA polymers produce transparent, flexible, oxygen permeable films which adhere to glass, plastics and metals.

PVP / VA Kopolimer Nedir?
PVP / VA Kopolimer ana saç bakm ürünlerinin çounda bulunan ve tutma faktörü salayan bileentir. Pek çok Hairsprray’de çok yaygndr; ayn zamanda jel, mum, pomat ve ekillendirici kremlerde bulunur. Petrolden elde edilen sentetik bir katk maddesidir.
PVP (ayn zamanda Polivinilpirolidon olarak da bilinir), 1950’lerin banda ilk baarl saç spreyinde kullanlan ana maddedir. Bu polimer suda çözünebildiinden saç spreyi olarak çalt. Bu, saçnz ykadnzda durulanabilecei anlamna geliyordu. PVP, 60’l yllarda o kadar yaygn olan saçlara yapkan bir görünüm kazandrarak havadaki su emme eilimindeydi.
Bu, polidimetilsiloksan ad verilen bir silikon olan baka bir polimer yardmyla sabitlendi. Bu silikonun daha iyi bir saç spreyi nasl hazrlandn anlamak için, saç spreyinin bata nasl çaltn anlamaya yardmc olur. Üzerine püskürtürken, polivinilpirolidon saç üzerinde ince bir kaplama oluturur. Bu kaplama katdr ve saçn etrafndan hareket etmesine engel olur. (Aadaki resme baknz)
Ne yazk ki hiç kimse bu Polimer ile gelen tehlikelerin farknda deildi. PVP / VA Kopolimer parçacklar solunursa hassas kiilerin akcierlerine zarar verebilir. Zehirli olduu düünülür, zira parçacklar insanlardaki akcierlerdeki yabanc cisimlere katkda bulunabilir. Birkaç yl öncesine kadar, bu madde kullanm güvenli kabul edildi ancak imdi kesinlikle önlenmesi daha iyi bir bileen.
Burada, bu bileeni ürünlerimizin herhangi birinde ve özellikle de Saç Spreyimizde kullanmyoruz. Greyfurt ve Lemon Grass Hairspray yalnzca size nazik deil, ayn zamanda aerosol kullanmayan ve çevre dostu bir tetik spreyine sahip olmas nedeniyle çevreye kar da nazik davranmaktadr. Bu güzel ürün doal bir UV koruyucusu içerir ve herhangi bir petro-kimyasal, plastik veya polimer anlamna gelmez. Bu nazik formül ayn zamanda göz ve saçl deri tahrileri anlamna gelmez.
Ashland, bir dizi vinilpirolidon / vinil asetat kopolimerini formülletiriciler sunmaktadr. PVP / VA kopolimer serisinin üyeleri, farkl derecelerde su direnci isteyen çeitli ürünlerdeki birincil film oluturucular olarak hizmet eder. Bu kopolimerler saç, cilt ve ahap, cam, kat ve metal gibi pürüzsüz yüzeyler için özel afiniteye sahiptir, ancak çkarma için çözücü gerektirmezler.
Film oluturucular olarak PVP / VA kopolimerleri kullanmann avantajlar unlardr:
• film esneklii
• iyi yapma
• su geçirimsizlik
• sertlik
Bu özellikler PVP / VA kopolimerlerini çeitli endüstriyel, kiisel bakm ve eczaclk ürünleri için uygundur. Ana endüstriyel uygulamalar, scakta eriyen yaptrclar, fotorezist balayclar ve mürekkep püskürtmeli ortam kad, plastik film ve dier yüzeyler için kaplamalardr.
• Dorusal, rastgele kopolimerler
• Vinil asetat içeriinin arttrlmas – hidrofobikliin arttrlmas, higroskopikliin azalmas, Tg’nin azaltlmas
• Cam, plastik ve metallere yapan hidrofilik, effaf, esnek termoplastik, oksijen geçirgen filmler
• Alkollerde, esterlerde ve ketonlarda çözünür, eterlerde ve alifatik hidrokarbonlarda çözünmez. VP içerii% 50’den fazla olduunda suda çözünür,
• Yapkan ve yapkan özellikler
• E = etanol (EtOH), I = izopropanol, W = su, S = kat
PVP / VA E ve I kopolimer serisi
Birçok uygulama alanna uymak için, PVP / VA kopolimerlerinin E ve I serileri srasyla etanol ve izopropanolde% 50 solüsyon olarak mevcuttur2. E grubunda dört ayr kopolimer vardr: E-335, E-535, E-635, E-735 ve I grubundaki üç: 1-335, 1-535, 1-735. Her biri monomer oran ve dolaysyla özelliklerde – su duyarll, viskozite, yumuama noktas vs. açsndan farkllk gösterir.
Bu, formüller, belirli uygulamalar için yeni ürünler yaratmada kayda deer esneklik salar. Bütün bu kopolimerlerin oluturduu effaf filmler yapma, parlaklk, sertlik ve suda slanabilme özellii ile karakterizedir. Pek çok modifikatör ve plastikletirici ile iyi uyumluluk, formülasyonda geni özgürlük salar ve higroskopiklik, film esneklii ve anma direnci araln geniletir. Vinil pirolidonun vinil asetata daha düük oranlara sahip olan modifiye edilmemi kopolimerler, yüksek oranlara sahip ürünlerden daha fazla nem direnci sergilemektedir.
PVP / VA S kopolimeri
Beyaz, kokusuz bir toz olan PVP / VA S-630 kopolimer, ayrca 60/40 VP / VA arlk orannda mevcuttur. Yaklak 70 ° C’lik bir minimum kritik çözelti scakl sergileyen, yüksek molekül arlkl, çözücü ve suda çözünür kopolimerdir. Çözeltilerden dökülen filmler parlak, yar effaf ve su ile slanabilinir.
PVP / VA W kopolimerleri S
PVP / VA W-735 kopolimer, suda% 50’lik bir solüsyon olarak verilen PVP ve vinil asetatn bir 70/30 kopolimeridir. PVP / VA-
W-635 kopolimeri ayrca% 50 sulu çözelti halinde temin edilen bir 60/40 kopolimerdir.
VA (vinil asetat), VP (vinilpirolidon) ‘dan daha hidrofobik bir moleküldür. Bu nedenle, kopolimerin VA içeriinin artmas, hidrofobikliin artmasna ve dolaysyla VP homopolimerine kyasla suda çözünürlüün ve higroskopikliin azalmasna neden olur.
Plastikletiriciler ve Polimerler: Çou PVP / VA kopolimeri, çeitli noniyonik ve katyonik polimerlerle uyumludur. Anyonik kopolimerlerle olan uyumluluk, kartrmadan önce nötrletirme yoluyla elde edilebilir.
Filmlerin Higroskopiklii: PVP / VA kopolimer filmlerinin doal su hassasiyeti monomer oran ile deiir. Tipik veriler PVP / VA E-735 kopolimer, PVP / VA E-535 kopolimer ve PVP / VA E- 335 kopolimeri için aada gösterilmitir. Genel olarak, PVP / VA kopolimeri PVP’den daha az higroskopiktir.
PVP / VA kopolimerleri, aadaki uygulamalarda ve pazarlarda mükemmel film oluturma özellikleri için yaygn olarak kullanlmaktadr:
• Kat, film ve dier yüzeylerde kaplamalar
• Suya dayanksz yapkanlar
• Suda çözünür yaptrclar
• Dekoratif ve koruyucu kaplamalar
• Fotorezist / lehim maskesi balayclar
• Biyoadezivler
• Koruyucu maskeler
Scakta eriyen yaptrclarda, PVP / VA kopolimerleri, listelenen çeitli suya dayankl veya sudan çkartlabilir yapkanlarda
altnda. Burada, formüle edicilere, film esneklii, yapkanlk ve sudan uzak tutma yeteneinde performans avantajlar sunuyoruz.
PVP / VA kopolimerleri, boya alcln artrmak için kat, plastik filmler ve dier substratlar dahil olmak üzere mürekkep püskürtme ortamlar için kaplamalarda da kullanlr. PVP / VA S-630 kopolimer, fotorezistlerin sulu ilenmesine izin vermek için bir birletirici olarak kullanlr.
Depolama ve tama
PVP / VA kopolimerleri normal depolama koullarnda en az bir yl istikrarldr, ancak nem almn önlemek için kat önlemler alnmaldr. E ve I serilerinde parlama noktalar var.
50-13 ° C (50-55 ° F) aralnda yanc (DOT Yanc) malzemeler olarak snflandrlmtr. Güvenlik nedenlerinden ötürü ve scaklk deiiklikleri ile birlikte davulun solunmas nedeniyle nem almn önlemek için 100 ° F’n (38 ° C) altnda kuru bir yerde saklayn ve patlamaya dayankl tesislerde yeniden paketleyin veya kullann.
PVP / VA polimerler cam, plastik ve metallere yapan effaf, esnek, oksijen geçirgen filmler üretirler.
Polivinilpirolidon / vinil asetat (PVP / VA) reçineler, monomerlerin, 70 / 30’dan 30 / 70’e kadar vinil asetattan vinilpirolidona kadar deien oranlarda serbest radikal polimerizasyonu ile üretilen dorusal, rasgele kopolimerlerdir.
PVP / VA kopolimerleri, etanol, izopropanol ve suda beyaz tozlar veya berrak çözeltiler halinde mevcuttur. Dört aralktaki vinilpirrolidon içeriindeki polimerler (30, 50, 60 ve yüzde 70) etanol veya izopropanol içinde üretilir. % 60 ve% 70 vinilpirrolidon içeriine sahip olan PVP / VA kopolimerler kat veya% 50 sulu çözeltiler olarak mevcuttur.
PVP / VA E- ve I-serisi
Daha fazla uygulama alanna uymak için, E- ve I serisi PVP / VA kopolimerleri srasyla etanol ve izopropanol ** içerisinde% 50 solüsyon olarak mevcuttur. E grubunda dört farkl kopolimer vardr: E-335, E-535, E-635, E-735 ve I gruptaki üç: I-335, I-535, I-735. Her biri monomer oran ve dolaysyla özelliklerde – su duyarll, viskozite, yumuama noktas vb. Açsndan farkllk gösterir. Bu, formülletiricilere özel uygulamalar için yeni ürünler yaratmada önemli esneklik salar. Bütün bu kopolimerlerin oluturduu effaf filmler yapma, parlaklk, sertlik ve suda slanabilme özellii ile karakterizedir. Pek çok deitirici ve plastikletirici ile iyi uyumluluk, formülasyonda geni özgürlük salar ve higroskopiklik, film esneklii ve anma direnci araln geniletir. Vinil pirolidonun vinil asetata oranlan daha düük oranlara sahip olan modifiye edilmemi kopolimerler, VP’ye oranla VA’ya oranla daha fazla nem direnci sergilemektedir.
PVP / VA W kopolimerleri
PVP / VA W-735, suda% 50’lik bir solüsyon olarak verilen PVP ve vinil asetatn bir 70/30 kopolimeridir. PVP / VA W-635,% 50 sulu çözelti halinde verilen 60/40 kopolimerdir. Alkolsüz köpükler ve jeller için ideal noniyonik fiksatif reçinelerdir. Formülatörlere, birikim, saç dökülme veya saç dökülme olmakszn olaanüstü kvrm ve stil tutma özellikleri sunar.
Plastikletiriciler ve polimerler: Çou PVP / VA kopolimeri, çeitli noniyonik ve katyonik polimerlerle uyumludur. Anyonik kopolimerlerle olan uyumluluk, kartrmadan önce nötrletirme yoluyla elde edilebilir.
Filmlerin higroskopiklii: PVP / VA kopolimer filmlerinin doal su hassasiyeti, monomer oran ile deiir. Tipik veriler aada PVP / VA E-735, PVP / VA E-535 ve PVP / VA E-335 için gösterilmitir. Genel olarak, PVP / VA, PVP’den daha az higroskopiktir.
Endüstriyel: Scakta eriyen yaptrclarda, PVP / VA kopolimerleri çeitli suda
Tekrar kapanabilir veya suyla çkarlabilir yapkanlar. Burada teklif ediyorlar
Film esneklii, yapkanlk ve suda formülatör performans avantajlar
remoistenability.
Su Geçirmez Yapkanl PVP / VA Tipi Yaptrclar
• Solvent bazl formülasyonlar E- ve I-serisi
• Scak eriyik S-630
• Scak eriyik, basnca duyarl, tekrar tekrar sarlabilir S-630
Zehirlilik verileri
PVP / VA kopolimer ailesinin üyeleri çok sayda
Hayvanlarda ve insan derisinde akut, alt-kronik ve kronik toksisite çalmalar
Klinik test. Sonuçlar, bu kopolimerlerin düük bir
Akut oral toksisite ve ne birincil dermal tahri edici ne de duyarllatrc maddeler deildir.
Alkol içindeki kopolimerlerin birincil göz tahrii çalmalar minimal gösteriyor
Alkol nedeniyle tavanda iddetli tahrie neden olabilir. Kronik çalmalar gösteriyor
Hem fare hem de sçanlarda oral uygulamay takiben hiçbir olumsuz etki ve
Tavanda ve hamsterde teneffüs.
soyut
Bu çalmada, kopolimer kompozisyonunun ilaç-polimer çözünürlüü üzerindeki etkisi aratrlmtr. Çeitli polivinilpirolidon / vinil asetat (PVP / VA) kopolimer bileimlerinde (70/30, 60/40, 50/50 ve 30/70 w / w) ve saf homopolimer polivinilpirolidonda (PVP) celecoxib modelinin (CCX) çözünürlüü ) Ve polivinil asetat (PVA), ar doymam amorf bir dispersiyonun (yeniden kristalletirme yöntemi) yeniden kristalletirilmesine dayanan bir termal analiz yöntemi kullanlarak 25 ° C’de öngörülmütür. Bu çözünürlükler, Flory-Huggins kafes teorisini (sv monomer çözünürlük yaklam) kullanarak PVP / VA, N-vinilpirolidon (NVP) ve vinil asetatn (VA) sv monomerik öncüllerinde CCX’in çözünürlüüne dayanan bir tahminle karlatrlmtr.
Sv monomer çözünürlük yaklamndan tahmin edilen çözünürlükler, artan VP / VA oran ile 0.03-0.60 w / w arasnda dorusal olarak artt. Yeniden kristalletirme yönteminden tahmin edilen çözünürlükler, VP / VA orannn 0.02-0.40 w / w arttkça artmasna ramen, tahmin edilen çözünürlük, yüksek VP / VA oranlarnda bir platoya yaklam gibiydi.
Gordon-Taylor denkleminden artan VP / VA oranndaki artan olumlu sapmalar, CCX ve VP tekrarlama birimi arasnda, her iki yöntemle de öngörülen nispeten yüksek çözünürlüklere uygun güçlü etkileimleri gösterdi.
Çözünürlük platosu, boyutun neden olduu sterik engelin bir sonucu olabilir.
Çözünürlük platosu CCX ve VP tekrar üniteleri arasndaki boyut farkllklarnn neden olduu sterik engelin bir sonucu olabileceinden, bir VP tekrar ünitesi ile etkileen bir CCX molekülünün, baka bir CCX molekülünü komu tekrar ünitelerine balanmasn engellemektedir Polimer zinciri.
Bu nedenle, bu komu higroskopik VP tekrar birimlerinin hidrofobik VA tekrar birimleriyle deitirilmesinin, ilaç-polimer çözünürlüünden ödün vermeden amorf bir kat dalmn fiziksel kararlln artrabilecei mümkündür. Bu bilgi, amorf ilaç verme sistemlerinin gelecekteki geliiminde avantajl bir ekilde kullanlabilir; çünkü kopolimerler en uygun ilaç-polimer çözünürlüü ve fiziksel stabilite salamak üzere özelletirilebilirler.

PVP/VA COPOLYMER (PVP/VA KOPOLMER)

Table of Contents

PVP/VA COPOLYMER (PVP/VA KOPOLMER)

Explore:

EXPLORE

INFORMATIONS

NEWSLETTER