SODIUM PCA
SODIUM PCA(SODYUM PCA)
CAS No.: 28874-51-3
EC No.: 249-277-1
Synonyms:
5-Oxo-L-proline monosodium salt; L-PCA-NA; l-pyrrolidone-5-carboxylic acid sodium salt; sodium l-pyroglutamate; Sodium PCA; sodium 5-oxo-L-prolinate; Sodium Pyrrolidone Carboxylate; L-PCA-Na=SodiumPCA; L-Pyroglutamicacidsodiumsalt; Pyroglutamic acid sodium salt; Sodium 2-pyrrolidone-5-carboxylate; L-Proline, 5-oxo-, monosodium salt; SODIUMPIDOLATE(SODIUMPCA); SODIUMPYROGLUTAMICACID; PYRROLIDONECARBOXYLATESODIUM; 5-oxo-, monosodium salt, L-(8CI; dium L-pyroglutamate; soydum pca; SODYUM PCA; Sodium L-pyrrolidonecarboxylate; xo-L-proline monosodium salt; Pyrrolidone Carboxylicacid-Na; PCA soda; PCA-Na; pyrrolidine-2-carboxylic acid, sodium salt; pyrrolidone-5-carboxylic acid; ajidew NL-50; aminosyl NL50; bio-plex NMF; bio-plex NMF-YD; proline monosodium salt; proline monosodium salt; proline, 5-oxo-, monosodium salt; proline, 5-oxo-, monosodium salt, L- (8CI); proline, 5-oxo-, sodium salt (1:1); sodium (2S)-5-oxopyrrolidine-2-carboxylate; sodium 5-oxo-L-prolinate; sodium 5-oxo-laevo-prolinate; sodium L-pyroglutamate; sodium L-pyrrolidonecarboxylate; sodium pidolate; Sodium L-pyroglutamate; 28874-51-3; soydum pca; SODYUM PCA; Sodium pidolate; Sodium pyroglutamate; Sodium 5-oxo-L-prolinate; L-Proline, 5-oxo-, monosodium salt; Ajidew N-50; L-5-Oxoproline monosodium salt; Sodium pyrrolidone-5-carboxylate; 5-Oxo-L-proline monosodium salt; UNII-1V74VH163T; Sodium L-pyrrolidonecarboxylate; Proline, 5-oxo-, monosodium salt; EINECS 249-277-1; Sodium (S)-5-oxopyrrolidine-2-carboxylate; Sodium PCA; 1V74VH163T; Proline, 5-oxo-, monosodium salt, L-; 5-Oxo-DL-proline, monosodium salt; PCA Soda; C5H6NNaO3; sodium (2S)-5-oxo-2-pyrrolidinecarboxylate; sodium (2S)-5-oxidanylidenepyrrolidine-2-carboxylate; PDSI 101; DL-Proline, 5-oxo-, monosodium salt; EC 249-277-1; SCHEMBL164853; DTXSID50183074; AKOS006277120; Sodium DL-2-pyrrolidone-5-carboxylate; LS-118970; CS-0112985; A819646; A830250; C-36564; soydum pca; SODYUM PCA; SODIUM (2S)-5-OXOPYRROLIDINE-2-CARBOXYLATE; Q27252940; UNII-469OTG57A2 component CRPCXAMJWCDHFM-DFWYDOINSA-M; sodium 5-oxopyrrolidine-2-carboxylate; Sodium 5-oxo-DL-prolinate; soydum pca; SODYUM PCA; Sodium pyrrolidone carboxylate; 2-Pyrrolidone-5-carboxylic acid sodium salt; Monosodium 5-oxoproline; Proline, 5-oxo-, sodium salt (1:1); Sodium PCA; sodium 2-pyrrolidone-5-carboxylate; PCA Soda; Nalidone; 5-Oxo-DL-proline, monosodium salt; DL-Proline, 5-oxo-, monosodium salt; C5H6NNaO3; DL-Sodium pyroglutamate; Sodium DL-pyroglutamate; sodium dl-pyrrolidonecarboxylate; 2-PYRROLIDONE-5-CARBOXYLIC ACID, SODIUM SALT, 50 WT% SOLUTION IN WATER; EINECS 259-234-9; odium 5-oxo-L-prolinate; SCHEMBL66285; KSC001A0H; CTK9A1003; DTXSID20885432; BCP11962; KS-000010OT; AKOS016010363; 2-Pyrrolidone-5-carboxylic acid sodium; AK116282; AS-65747; P408; AX8021364; DB-052609; FT-0659599; 2-Pyrrolidone-5-carboxylic acid, sodium salt; Q27258924; 5-Oxo-L-proline monosodium salt;Sodium pysoydum pca; SODYUM PCA; roglutamate;L-PCA-NA;Sodium PCA; soydum pca; SODYUM PCA; Sodium L-pyroglutamate; 28874-51-3; Sodium pidolate; Sodium pyroglutamate; Sodium 5-oxo-L-prolinate; L-Proline, 5-oxo-, monosodium salt; Ajidew N-50; L-5-Oxoproline monosodium salt; Sodium pyrrolidone-5-carboxylate; 5-Oxo-L-proline monosodium salt; UNII-1V74VH163T; Sodium L-pyrrolidonecarboxylate; Proline, 5-oxo-, monosodium salt; EINECS 249-277-1; Sodium (S)-5-oxopyrrolidine-2-carboxylate; Sodium PCA; 1V74VH163T; Proline, 5-oxo-, monosodium salt, L-; 5-Oxo-DL-proline, monosodium salt; PCA Soda; C5H6NNaO3; sodium (2S)-5-oxo-2-pyrrolidinecarboxylate; sodium (2S)-5-oxidanylidenepyrrolidine-2-carboxylate; PDSI 101; DL-Proline, 5-oxo-, monosodium salt; EC 249-277-1; SCHEMBL164853; DTXSID50183074; AKOS006277120; Sodium DL-2-pyrrolidone-5-carboxylate; LS-118970; CS-0112985; A819646; A830250; C-36564; SODIUM (2S)-5-OXOPYRROLIDINE-2-CARBOXYLATE; Q27252940; UNII-469OTG57A2 component CRPCXAMJWCDHFM-DFWYDOINSA-M; pyrrolidone carboxylic acid; 1-Pyrrolidinecarboxylic acid, 2-oxo-; 115621-24-4; ACMC-20ml32; SCHEMBL59155; CTK0C6331; DTXSID20431796; CHEBI:139123; 2-oxo-1-pyrrolidinecarboxylic acid; 5-Oxopyrrolidine-1-carboxylic acid; 2-oxidanylidenepyrrolidine-1-carboxylic acid; A845910; Monosodium 5-oxoproline; Sodium pyrrolidone carboxylate; 5-Oxo-DL-proline, monosodium salt; DL-proline, 5-oxo-, monosodium salt; Nalidone; PCA soda; Sodium PCA; Sodium pyroglutamate; UNII-469OTG57A2; Proline, 5-oxo-, monosodium salt; Proline, 5-oxo-, sodium salt (1:1); Sodium 5-oxo-DL-prolinate; (2R)-5-oxopyrrolidine-2-carboxylate; 2-Pyrrolidone-5-carboxylic acid sodium salt; L-PCA-NA; Sodium PCA; L-PCA-Na=SodiumPCA; dium L-pyroglutamate; Sodium L-pyroglutama; sodium l-pyroglutamate; SODIUMPYROGLUTAMICACID; sodium 5-oxo-L-prolinate; 5-Oxoproline sodium salt; SODIUMPIDOLATE(SODIUMPCA); soydum pca; SODYUM PCA; 115621-24-4; ACMC-20ml32; SCHEMBL59155; CTK0C6331; DTXSID20431796; CHEBI:139123; 2-oxo-1-pyrrolidinecarboxylic acid; 5-Oxopyrrolidine-1-carboxylic acid; 2-oxidanylidenepyrrolidine-1-carboxylic acid; A845910; Monosodium 5-oxoproline; Sodium pyrrolidone carboxylate; 5-Oxo-DL-proline, monosodium salt; DL-proline, 5-oxo-, monosodium salt; Nalidone; PCA soda; Sodium PCA; Sodium pyroglutamate; UNII-469OTG57A2; Proline, 5-oxo-, monosodium salt; Proline, 5-oxo-, sodium salt (1:1); Sodium 5-oxo-DL-prolinate; (2R)-5-oxopyrrolidine-2-carboxylate; 2-Pyrrolidone-5-carboxylic acid sodium salt; L-PCA-NA; Sodium PCA; L-PCA-Na=SodiumPCA; dium L-pyroglutamate; Sodium L-pyroglutama; sodium l-pyroglutamate; SODIUMPYROGLUTAMICACID; sodium 5-oxo-L-prolinate; 5-Oxoproline sodium salt; SODIUMPIDOLATE(SODIUMPCA); soydum pca; SODYUM PCA
SODIUM PCA
Please consult your doctor or pharmacist or read the package insert.
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Sodium Pca / Cyclopentasiloxane – Uses, Side-Effects, Reviews, and Precautions –
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Sodium Pca / Cyclopentasiloxane for skin conditioning
Sodium Pca / Cyclopentasiloxane for hair conditioning
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Consumer Survey – Sodium Pca / Cyclopentasiloxane
The following are the results of an ongoing survey on TabletWise.com for Sodium Pca / Cyclopentasiloxane. These results only show the perceptions of the users of this website. Please make your medical decisions based on the advice of a doctor or a specialist.
Uses, Efficiency and Side Effects
The following are information on the usage, perceived efficiency and frequency of side effects offered by site visitors for Sodium Pca / Cyclopentasiloxane:
Overdose of Sodium Pca / Cyclopentasiloxane
Do not use more than prescribed dose. Consuming more of the drug will not improve your symptoms; on the contrary, it can cause poisoning or serious side effects. If you suspect that you or a relative has used an overdose of Sodium Pca / Cyclopentasiloxane, please visit your nearest hospital emergency department. To help doctors, bring necessary information such as a medicine box, bottle, or label.
Do not give your medication to someone else, even if you know they have the same condition or they seem to have similar conditions. This can cause an overdose.
For more information, consult your pharmacist or check the package insert.
Storage of Sodium Pca / Cyclopentasiloxane
Store medicines at room temperature, away from heat and light. Do not freeze medicines unless it is written on the package insert. Keep medicines out of the reach of children and pets.
Do not pour medicines into the toilet or sink unless you are told to do so in the package insert. Drugs disposed in this way can pollute the nature. Please consult your pharmacist or doctor for more details on how to safely discard Sodium Pca / Cyclopentasiloxane.
Expired Sodium Pca / Cyclopentasiloxane
Taking a single dose of expired Sodium Pca / Cyclopentasiloxane is likely to cause an adverse event. Consult your family doctor or pharmacist for appropriate advice or if you feel unwell. Expired drugs will not be effective in treating conditions on your prescription. In order to stay safe, it is very important not to use expired medications. If you have a chronic illness that requires constant medication, such as heart disease, seizures, and life-threatening allergies, it is even more important to stay in touch with your GP so that you can replace expired medications immediately.
Dosage Information
Is this drug or product addictive or addictive?
Many drugs are not marketed as addictive or abusive. Often ministries categorize drugs into controlled and non-addictive drugs. For example, this classification is H and X in India and II and V in the USA. Please check the box to make sure the drug belongs to such a special classification. Finally, do not try to self-medicate and increase your body`s dependence without the advice of a doctor.
Can I stop using this product immediately or do I get rid of it gradually?
Some drugs should be tapered or their use should not be stopped suddenly to avoid withdrawal effects. Consult your doctor for recommendations specific to your body and health condition and other medications you can use.
Other important information on Sodium Pca / Cyclopentasiloxane
Forgetting to take a dose
If you forget to take a dose, use it immediately. If your next dose is too close to your time, stop taking the missed dose and stick to your dosing schedule. Do not take extra doses to treat the missed dose. If you regularly forget your doses, set an alarm or ask a family member to remind you. Please consult your doctor to make changes to your dosing schedule or to make up for missed doses if you have recently forgotten too many doses.
Before using this medicine, you should inform your doctor about the medicines you are currently using, the medicines you are using without a prescription (e.g. vitamins, herbal supplements, etc.), allergies, your past illnesses and your current health condition (e.g. pregnancy, upcoming surgery, etc.) inform. Certain health conditions can make you more susceptible to the side effects of the medication. Take the steps as directed by your doctor or consider what is written on the product. The dosage depends on your condition. If your condition persists or worsens, notify your doctor. Key issues to consult are listed below.
Planning to get pregnant, pregnant or breastfeeding
Please consult your doctor or pharmacist or refer to the package insert for this information.
Hypersensitivity to Sodium Pca / Cyclopentasiloxane is a contraindication. In addition, Sodium Pca / Cyclopentasiloxane should not be used if you have the following conditions:
Hypersensitivity
Frequently Asked Questions
Is it safe to drive or use heavy machinery while using this product?
If you experience side effects such as drowsiness, dizziness, hypotension (low blood pressure) or headache while using Sodium Pca / Cyclopentasiloxane, it may not be safe to drive and / or use a construction machine. If the medication used causes drowsiness, dizziness or lowers your blood pressure, you should not drive. In addition, pharmacists advise patients not to drink alcohol with the drug, as alcohol intensifies side effects such as drowsiness. Please check for these effects on your body when using Sodium Pca / Cyclopentasiloxane. Always consult your doctor for advice specific to your body and health condition.
Sodium Pca / Cyclopentasiloxane
Medicine Sodium Pca / Cyclopentasiloxane
Overview Uses Side effects Precautions Interactions Contraindications
Overview
Sodium Pca / Cyclopentasiloxane combination is used for Skin conditioning, Hair conditioning and other conditions.
Detailed information on the use of Sodium Pca / Cyclopentasiloxane product, side effects, product comments, questions, interactions and precautions are as follows:
uses
Sodium Pca / Cyclopentasiloxane is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
Skin conditioning
Hair softening
Further information: Uses
Side effects
The following is a list of possible side-effects that may occur in medicines that contain Sodium Pca / Cyclopentasiloxane. This is not an exhaustive list. These side effects are likely to occur, but do not always occur. Some of the side effects are rare but can be very serious. Be sure to consult your doctor if you observe any of the following side effects, especially those that do not go away even if you expect them to.
Skin irritation
Hives
If you notice any side effects other than those listed below, consult your doctor for medical advice. You can also report side effects to your nearest health department official.
Measures
Limnanthes Alba (Meadowfoam) Seed Oil, Rosa Damascena Flower Water, Beeswax (Cera Alba), Pentylene Glycol, Corylus Avellana (Hazel) Seed Oil, Ormenis Multicaulis Flower Wax, Sodium PCA Carbonate Decahydrate, Limonene, Citrus Medica Lemonum (Lemon) Peel Oil, Osmanthus Fragrans Flower Extract, Anthemis Nobilis Flower Oil, Tocopherol, Citronellol, Geraniol, Citral.
If you have oily skin, avoid the first line items in their products being oil. In this case, make sure that the moisturizing agents are glycerin, sodium PCA, hyaluronic acid or sodium PCA hyaluronate.
Amino acid cocktail: It contains Sodium PCA and 8 types of amino acids found in the skin`s own structure. It is very effective in the care of mature skin. It helps the skin to be nourished and restructured. Bifida Ferment Lysate: It is an antiaging active with proven effectiveness. It prevents the damage of UV light on DNA. It helps to repair wrinkles by helping to repair DNA. 50ml
Content: Sodium PCA: Protects against dryness by allowing the skin to retain more moisture. It is a natural and important moisturizing agent that is also found in the skin structure.
Content:
Amino acid cocktail: It contains Sodium PCA and 8 types of amino acids found in the skin`s own structure. It is very effective in the care of mature skin. It helps the skin to be nourished and restructured. Glycine Soybean Seed Extract: Increases the strength of the skin with protein, glycoprotein and polysaccharides obtained from soy, renews the skin and revitalizes the skin cells. It helps prevent premature aging effects caused by UV rays and DNA damage on the skin. UVA / UVB Protection Factor: It contains a protection factor of 15 SPF. 50ml
Hyaluronic acid, one of the most effective moisture retainers, has a water holding capacity of 1000 times its own weight. It has a tightening effect. It increases the elasticity of the skin. It ensures the transmission of moisture to all cells in the skin. Provides moisturization for a long time on the skin. These products, which plump the skin and provide moisture for a long time, are suitable for day and night use. It also ensures that the skin is smooth and even toned.
Active Ingredients / Active Ingredients
Sodium PCA, Sodium hyaluronate, Panthenol
10 x 2 ml
Sodium PCA
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Overview(active tab)
Safety
Resources
What Is It?
In cosmetics and personal care products, Sodium PCA (pyrrolidonecarboxylic acid) is used mostly in the formulation of hair conditioners and moisturizers. The sodium PCA salt of Sodium PCA, Sodium PCA, can be found in these products, as well as in shampoos, hair sprays, permanent waves, skin fresheners and other hair and skin care products.
Why is it used in cosmetics and personal care products?
Sodium PCA and Sodium PCA increase the water content of the top layers of the skin by drawing moisture from the surrounding air. They also enhance the appearance and feel of hair, by increasing hair body, suppleness, or sheen, or by improving the texture of hair that has been damaged physically or by chemical treatment.
Abstract
Sodium PCA pyrrolidone carboxylic acid is the sodium PCA salts of 2 pyrrolidone 5 carboxylate, It is one of the major Natural Moisturing factor (NMF) found in human skin. It is documented that sodium PCA pyrrolidone carboxylic acid (Na- Sodium PCA) is used in hair care & skin care products with great effectivity as it is water extracting skin component. As Na- Sodium PCA is the Natural Moisturizing Agent, it gives suppleness, humectancy & moisturizing property. It is being water soluble, therefore an oil in water (O/W) cream base decided to develop. Three formulae were developed in laboratory incorporating 2.5% & 5% of Na- Sodium PCA &7.5% glycerine. Three cream prepared were further studied for its stability with reference to effect of temp. i.e. at Room Temp.-24-28c,at oven 50c, & at refrigerator 90c, change in colour, odour, pH, globules size & viscosity. It was further decided to study the performance evaluation.
Details
Sodium PCA stands for Pyrrolidone Carboxylic Acid and though it might not sound like it, it is a thing that can be found naturally in our skin. The sodium PCA salt form of Sodium PCA is an important skin-identical ingredient and great natural moisturizer that helps the skin to hold onto water and stay nicely hydrated.
Description: Sodium PCA is the sodium PCA salt of pyroglutamic acid which is an uncommon amino acid found naturally in many proteins. Concentration: 50% (dissolved in water). GMO-free, gluten-free. Colorless to pale yellow clear liquid, soluble in water, pH 6.8-7.4.
CAS: 28874-51-3
INCI Name: Sodium PCA (sodium L-pyroglutamate)
Benefits:
Occurs naturally in human skin and is responsible for binding moisture to the cells
Highly water-absorbent, holding several time its weight in water, which makes it an excellent humectant
Well-know as skin-penetration enhancer
Stronger hydrating agent than the traditional compounds like glycerin or propylene glycol
Good for hair care as it reduces static electricity.
Use: Add as is to the water phase of the formulas, typical use level 1 – 10% in emulsions. For external use only.
Applications: All kinds of skin care products such as creams, gels, lotions, hair care products, color cosmetics.
Country of Origin: USA
Raw material source: The original amino acid proline is obtained mainly from fruits and coconut oil.
Manufacture: A fermentation process of sugars and starches is then used in order to create Sodium PCA from proline.
Animal Testing: Not animal tested
GMO: GMO-free but not certified
Vegan: Does not contain any animal-derived components
SODIUM PCA
SODIUM PCA is classified as :
Antistatic
Hair conditioning
Humectant
Skin conditioning
CAS Number 28874-51-3
EINECS/ELINCS No: 249-277-1
COSING REF No: 79910
Chem/IUPAC Name: Sodium PCA 5-oxo-2-pyrrolidinecarboxylate
Sodium PCA is the sodium PCA salt of pyroglutamic acid (also known as Sodium PCA). Sodium PCA is a naturally occurring component of human skin and a part of the “natural moisturizing factors” (NMF) that maintain a healthy epidermis. Sodium PCA is very hygroscopic, attracting moisture from the air. It imparts a moist feeling to hair and skin. Sodium PCA applied to the skin is absorbed to a limited extent. It is non-comedogenic, nonirritating to the eye and skin — even at concentrations up to 50%, and does not contribute to phototoxicity or sensitization. It is rapidly biodegradable. Soluble in water and ethanol and insoluble in oils, it is used for its powerful humectant properties in many skin and hair care products including gels, creams, lotions, shampoos, conditioners, lipsticks and foundations.
This Sodium PCA is sourced from all-natural, vegetable-based ingredients; it contains no animal-based ingredients of any kind.
INCI: Sodium PCA
INCI: Sodium PCA 50%
pH-value 6,8-7,4%
Dosage: 0,5 – 10%
Sodium PCA is a kind of natural moisturizing factor(NMF). It becomes an important additive ingredient in skin-care and hair-care cosmetics in the recent years. It has stronger hydrating power than that of glycerin, sorbitol and propanediol.
What is Sodium PCA?
Jun 08, 2019
Sodium PCA levels in the skin are highest during childhood. As time progresses, these levels can drop significantly. Using skin care products containing Sodium PCA can help increase these levels as you age. Sodium PCA also contains antioxidants that fight free radicals that can age the skin. It also contains vitamins D and E, which can aid in skin rejuvenation.
This powerful moisturizer is made from many herbs, but sodium PCA from each herb is used to do different things. For example, Sodium PCA from herbs and vegetables can be used as an emollient. When Sodium PCA is derived from coconut oil, it is used as an emulsifier. Sodium PCA found in cherry or seaweed can replenish moisture inside the skin. Sodium PCA can also be used in certain types of lotions that protect the skin from excessive sunlight.
This ingredient not only draws moisture into the skin but can also help keep it in. This makes it best suited for all skincare products. When sodium PCA is used in soaps, it can help the skin in many ways. It works with the natural Sodium PCA found in the skin to create a healthier and renewed skin.
Sodium PCA used in shampoos and conditioners helps to retain water in the hair shaft. It can also add shine and bounce to hair. When the hair is very dry, static can build up, causing difficult-to-manage, flying hair. Sodium PCA keeps enough moisture in the hair to eliminate frizzy and dry hair.
In small quantities, the use of sodium PCA is not considered harmful. It is considered to be mildly toxic, but is sometimes used with nitrosamine, which is thought to be a toxin. There were no known skin or eye irritations associated with the use of Sodium PCA.
Effects of lactic acid and sodium PCA pyrrolidone carboxylic acid on the irritated skin reaction induced by sodium PCA lauryl sulphate patch testing of normal persons and atopic dermatitis patients
Background: Natural moisturizing factors such as sodium PCA pyrrolidone carboxylic acid and lactic acid may play an important role in increasing the moisture retention of isolated stratum corneum and reducing the incidence of dry and flaky skin in vivo. Although the precise mechanism of surfactant irritancy is not fully understood, it has been suggested that barrier dysfunction of stratum corneum by surfactants results in skin changes such as scaling, erythema, and even fissuring. Objective: We evaluated the effect of sodium PCA pyrrolidone carboxylic acid(Na Sodium PCA) and lactic acid(LA) with several non-invasive measuring methods in the irritated skin reaction induced by sodium PCA lauryl sulphate (SLS) in normal persons and atopic dermatitis patients. Methods: After skin irritation for 24 hours with patch test of 1% SLS on five volar sites of right forearm, we applied nothing(A), 3% LA+3% Na Sodium PCA PCA(B), 3% LA(C), 3% Na Sodium PCA(D), and vehicle(E) twice a day respectively. Visual score, transepidermal water loss(TEWL), water holding capacity(WHC), and erythema index were measured at 30 min, 24hr, 48hr and 72hr after patch removal. Results: 1. After 72hr, the visual scores of B and C were significantly lower than that of A(control) in atopic dermatitis patients, and that of C in normal persons was significantly lower than that of A, D, and E. 2. TEWL values of B and C in both the normal (after 72hr) and atopic dermatitis group (after 48hr and 72hr) were significantly lower than that of A. 3. WHC values of B, C, D in both the normal and atopic dermatitis group were significantly higher than that of A after 48hr and 72hr. 4. After 72hr, erythema indices by Mexameter of B, C, and D in both the normal and atopic dermatitis group were significantly lower than that of A and values of C were significantly lower than that of E. In the atopic dermatitis group, values of D were also significantly lower than that of E. 5. The mean visual score was significantly correlated with TEWL value and erythema index of Mexameter (r=0.58, r=0.64) and the TEWL value was significantly correlated with erythema index of Mexameter (r=0.64). Conclusion: These results suggest that topical application of a moisturizing factor might improve the surfactant-induced disruption of permeability barrier with improvement of the water holding capacity of the stratum corneum.
Sodium PCA Pyrrolidone Carboxylic Acid As Moisturizing Agent
Abstract: Sodium PCA pyrrolidone carboxylic acid is the sodium PCA salts of 2 pyrrolidone 5 carboxylate, It is one of
the major Natural Moisturing factor (NMF) found in human skin. It is documented that sodium PCA pyrrolidone
carboxylic acid (Na- Sodium PCA) is used in hair care & skin care products with great effectivity as it is water extracting
skin component.
As Na- Sodium PCA is the Natural Moisturizing Agent, it gives suppleness, humectancy & moisturizing property .It is
being water soluble,therefore an oil in water (O/W) cream base decided to develop.
Three formulae were developed in laboratory incorporating 2.5% & 5% of Na- Sodium PCA &7.5% glycerine.
Three cream prepared were further studied for its stability with reference to effect of temp.i.e. at Room Temp.- 24-280c,at oven 500c, & at refrigerator 900c, change in colour, odour, pH, globules size & viscosity.It was
further decided to study the performance evaluation.
Key Words: Na- Sodium PCA, NMF, Moisturizing Agent.
1. Introduction:
By Kligman, Moisturizer is defined as a topically applied substance or product that overcomes the signs&
symptoms of dry skin. Idson defined as ,a Moisturizer,a substance that can favourably affect the feeling of dry skin ,by influencing the
water content of stratum corneum
1
. The approach to restoring water to dry skin has taken three different routes. 1.Occulsion
2.Humectancy
3.Restoration of deficient materials which may be combined.
The first approach,occlusion consists in reducing the rate of transepidermal water loss through old or damaged
skin or in protecting otherwise healthy skin from the effect of a severely drying environment.
The second approach to the moisturizing problem is the use of humectants to attract water from the atmosphere,
so supplementing the skins water content.
The third & perhaps the most valuable approach to moisturization of skin is to determine the precise mechanism
of the natural moisturization process to assess what has gone wrong with it in the case of dry skin & to replace
any materials in which such research has shown damaged skin to be deficient2
. Moisturizers often contain lipids & humectants of low molecular weight, humectants such as urea ,glycerine,
lactic acid, pyrrolidone carboxylic acid (Sodium PCA) and salts are absorb into the stratum cornium and their by
attracting water, increase hydration3
1.1 Natural Moisturizing Factor(NMF) A Group of water soluble hydrophilic substances known as the natural moisturizing factor (NMF)4
. Analysis of water soluble component of stratum cornium have indicated the presence of amino acid lactic acid
,sugar and pyrolidone carboxylic acid.The latter material is found in relatively large concentration in cornified
skin.It has recently been shown that salts of this material are extremely ,hygroscopic, dissolving in their own
water of hydrations.
At pH of stratum corneum (pH5) pyrolidone carboxylic acid exists almost exclusively in the salt form. There
result suggest that this material may represent one of the important natural Moisturizing agent for skin5
. Laden and spitzer proved that significant quantities of Na-2-pyrrolidone -5 carboxylate exist in the stratum.This
compound is now commercially available for use in cosmetics6
. 1.2 Composition of NMF
Amino acids 40%
Sodium PCA(Pyrrolidone carboxylic acid) 12%
Lactates 12%
Urea 7%
NH3,Uric acid, glucosamine, creatinine 1.5%
Citrates 0.5%
Na 5%, k 4%, Ca 1.5 %, Mg 1.5% , Po4 0.5% 18.5 %
Sucrore, Organic acid, Peptides, Other aterials 8.5%
1.3 Pyrrolidone Carboxylic Acid(Sodium PCA) ;(C5H7N03)
Molecular wt 129.11 7
1.4 Sodium PCA pyrrolidone carboxylic acid (NA- Sodium PCA);(C5H6NNa03)
Molecular wt 151.1 8
Na- Sodium PCA is one of the major natural moisturizing factors(NME) found in human skin.
It is the sodium PCA salts of 2 Pyrrolidone-5-Carboxylate(Na- Sodium PCA) is manufactured by dehydration of glutanic acid
and forms as odourless solid.
Sodium PCA -2 Pyrrolidone-5-Carboxylate has been Patented as a humactant at concentration of 2 % or higher.
Water absorption ability of Sodium PCA Pyrrolidone Carboxylate9
Compound %Moisture
intake(31%RH)
%Moisture
intake(58%RH)
Pyrrolidone Carboxylic Acid
Sodium PCA Pyrrolidone Carboxylic Acid 20 61
Glycerine 13 35
1.5 Uses of Sodium PCA Pyrrolidone Carboxylate in Cosmetics 10
1) Sodium PCA -2-pyrrolidone-5-carboxylate is an important humectants component of NMF.
2) It is used in moisturizing dry flacky skin.
3) It demonstrates excellent hygroscopc & humectants effect & these properties have been achieved with a salt
form.
4) Skin & hair care products,suncare,make-up,product are among the major application for Na- Sodium PCA.
5) It moisturizes &protects skin from wind,cold.
S.Bhise/Int.J.ChemTech Res.2013,5(4) 1450
2. Materials & Methods
Three O/W formulation were developed in laboratory incorporating glycerine & sodium PCA pyrrolidone carboxylic
acid(Na- Sodium PCA). 2.1 Formulation Notation
A- Base formulation with 7.5% glycerine.
B- Formulation with 2.5% Na- Sodium PCA.
C- Formulation with 5.0% Na- Sodium PCA.
2.2 Stability study for Finished Product.
All the three samples prepared were subjected to accelerated test conditions & were kept at room temp 24-28
0c,in oven at 50 0c & in refrigerator at 5-8 0c.
Stability studies were carried out by accelerated stability test for 40 days.
2.3 Performance Evaluation
Ten volunteers were persuaded & then selected. Two cream samples were given to each volunteer one is
control i.e. sample- A (7.5% glycerine)& other is sample-C(5% Na- Sodium PCA).Cream was applied twice a day on 3
cm.area of forehand.Sample A on right forehand &sample C on left forehand.
sked to see & compaire the effect of sample A & C after two hours upto 30 days.
3. Results & Discussion
1) Result of colour change indicate that at room temp.& at 50 0c the degree of colour change was inversely
proportional to the concentration of sodium PCA, on refrigeration there was no change in colour
Summary The medical and biological literature was reviewed with stress laid on the role of pyrrolidone carboxylic acid (Sodium PCA) and its sodium PCA salt (Na Sodium PCA) in skin, its metabolism, its functions. The paper also includes a summary of 8 years of evaluation work carried out in our Laboratory on creams and lotions containing Sodium PCA-Na Sodium PCA which were assessed by biophysical (impedance measurement, alpha relaxation) and clinical methods. It is now definitely demonstrated that Sodium PCA is an hydrating agent and that all the cosmetic preparations containing at least 2% of the Sodium PCA-Na Sodium PCA salt system improve the condition of dry skin at short or long term provided an adequate vehicle is used (e.g. aqueous solutions are ineffective). The mecanism of action is discussed with reference to metabolism and physiological role of Sodium PCA in stratum corneum.
Pyroglutamic acid (also known as Sodium PCA, 5-oxoproline, pidolic acid, or pyroglutamate for its basic form) exists as two distinct enantiomers: (2R) or D and (2S) or L. L-form is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase. L-Pyroglutamic acid is produced in the skin through the arginine-citrulline-ornitine-glutamic pathway. The free acid is not hygroscopic; however, the sodium PCA salts of this acid are more hygroscopic than glycerine. Therefore, formulation of this acid is suggested as a defense against dehydration, for skin conditions involving desquamation. Hydromol Cream (main component of that is sodium PCA pyrrolidone carboxylate (L form)) is a soft cream which moisturises the skin. Hydromol Cream contains a naturally occurring moisturising agent as well as oils, which prevent moisture loss from the skin. This helps to relieve itch, lubricate and soften the skin. Hydromol Cream is used to treat any condition in which dry skin is a feature such as eczema, ichthyosis (hereditary dry skin) and senile pruritus (itching that may occur in old age). L-Pyroglutamic acid is present in living cells has been reported from archaebacteria to humans, and its occurrence in living cells has been known for over a century. Despite its almost ubiquitous presence, the role of pyroglutamic acid in living cells is poorly understood. Pyroglutamic acid is found as an N-terminal modification in many neuronal peptides and hormones that also include the accumulating peptides in Alzheimers disease and familial dementia. The modification is also observed in proteins that include many antibodies, some enzymes and structural proteins.
yrrolidone carboxylic acid (Sodium PCA), the primary constituent of the natural moisturizing factor (NMF),1 including its derivatives such as simple2 and novel3 esters as well as sugar complexes4 is the subject of great interest and research regarding its capacity to moisturize the stratum corneum via topical application.
Creams and lotions containing the sodium PCA salt of Sodium PCA are widely reported to aid in hydrating the skin and ameliorating dry flaky skin conditions.5,6 In addition, the zinc salt of L-pyrrolidone carboxylate is a longtime cosmetic ingredient due to antimicrobial and astringent qualities. This column briefly addresses the role of Sodium PCA in skin health.7
Dry skin
In a comprehensive literature review from 1981, Clar and Fourtanier reported conclusive evidence that Sodium PCA acts as a hydrating agent and that all the cosmetic formulations with a minimum of 2% Sodium PCA and Sodium PCA salt that they tested in their own 8-year study enhanced dry skin in short- and long-term conditions given suitable vehicles (no aqueous solutions).6
In a 2014 clinical study of 64 healthy white women with either normal or cosmetic dry skin, Feng et al. noted that tape stripped samples of stratum corneum revealed significantly lower ratios of free amino acids to protein and Sodium PCA to protein. This was associated with decreased hydration levels compared with normal skin. The investigators concluded that lower NMF levels across the depth of the stratum corneum and reduced cohesivity characterize cosmetic dry skin and that these clinical endpoints merit attention in evaluating the usefulness of treatments for dry skin.8
In 2016, Wei et al. reported on their assessment of the barrier function, hydration, and dryness of the lower leg skin of 25 female patients during the winter and then in the subsequent summer. They found that Sodium PCA levels were significantly greater during the summer, as were keratins. Hydration was also higher during the summer, while transepidermal water loss and visual dryness grades were substantially lower.9
Atopic dermatitis
A 2014 clinical study by Brandt et al. in patients with skin prone to developing atopic dermatitis (AD) revealed that a body wash composed of the filaggrin metabolites arginine and Sodium PCA was well tolerated and diminished pruritus. Patients reported liking the product and suggested that it improved their quality of life.10
Later that year, Jung et al. characterized the relationship of Sodium PCA levels, and other factors, with the clinical severity of AD. Specifically, in a study of 73 subjects (21 with mild AD, 21 with moderate to severe AD, 13 with X-linked ichthyosis as a negative control for filaggrin gene mutation, and 18 healthy controls), the investigators assessed transepidermal water loss, stratum corneum hydration, and skin surface pH. They found that Sodium PCA levels and caspase-14 were lower in inflammatory lesions compared with nonlesional skin in subjects with AD. These levels also were associated with clinical AD severity as measured by eczema area and severity index scores as well as skin barrier function.11
Sodium PCA Pyrrolidone Carboxylic Acid
CAS No.: 28874-51-3
EINECS.: 249-277-1
Moisturizer agent
Appearance: Light yellow liquid
Sodium PCA Pyrrolidone Carboxylic Acid, Sodium Pca
QUICK LINKS
Alkyl Polyglucosides
Amino Acid Surfactants
Cosmetic Additives
Glyphosate surfactant
Quick Details
CAS No.: 28874-51-3
Other Names: Sodium Pca, Sodium L-pyroglutamate
Appearance: Pale yellow lyophilized mass
Description
Sodium PCA is a kind of natural moisturizing factor. It becomes an important additive ingredient in skin-care and hair-care cosmetics in recent years.
The stronger hydrating is power than that of glycerin, sorbitol and propanediol and non-poisonous, non-irritant, and non-allergic.
Mainly used in cream cosmetics, solutions, shampoo, etc., but also in place of glycerin for toothpaste, ointment drugs, tobacco, leather, coatings for wetting agents, and chemical fiber dyeing auxiliaries, softeners, antistatic agent, Is also biochemical reagents.
Cosmetic insulation agent
Sodium PCA Department of natural moisturizing factor is one of the important ingredients, high moisture absorption, and non-toxic, non-stimulating, good stability, is the modern skincare ideal natural make-up health care products, can skin and hair with wetting, Softness, elasticity, and gloss, and antistatic property.
Skin whitening agent
Sodium PCA is an excellent skin whitening agent, the inhibition of tyrosine oxidase activity can prevent the “melanoid” in the skin deposition so that the skin white.
Horny softening agent
Sodium PCA can do keratin softening agent, the skin “psoriasis” have a good therapeutic effect.
It is mainly used in cream cosmetics, solutions, shampoo, etc., also used in glycerin for toothpaste, ointment drugs, tobacco, leather, paint as wetting agents, and chemical fiber dyeing auxiliaries, softeners, Anti-static agent, is also biochemical reagents.
Recommendatory volumes of usage in creams:2%~8%
Recommendatory volumes of usage in creams:1%~3%
Specification
SODYUM PCA
Sodyum PCA, eitli cilt ve sa bakm rnlerinde nemlendirici bir madde ve cilt yenileyici bir bileen olarak ilev gren doal olarak oluan bir nemlendiricidir. Sodyum PCA ncelikle jeller, kremler, losyonlar, ampuanlar, klimalar, rujlar ve temeller dahil olmak zere cilt ve sa bakm rnlerinde nemlendirici bir nemlendirici olarak ilev grr. Tipik olarak %0.2 -4 arasnda bir konsantrasyon aralnda kullanlr. Bir nemlendirici, genellikle birka hidrofilik (su seven) gruba sahip molekler bir yapya sahip olan higroskopik bir maddedir. Bu yap, nemlendiricilerin emme yoluyla yakndaki havadaki nemi ekmesine ve tutmasna izin verir, su buharn yzeyin iine veya altna eker. Bir nemlendirici olarak, sodyum PCA cildi nemli tutmaya yardmc olur ve ayrca dier topikal cilt bakm bileenlerinin daha iyi performans gstermesine yardmc olabilir. Yukarda belirtildii gibi, Sodyum PCA cildin NMFNN doal bir bileenidir. Bu nedenle, topikal olarak uygulanan sodyum PCA NMFY taklit edebilir.
Sodyum PCA
Sodyum PCA (Pyrrolidone Carboxylic Acid). Sodyum pca cildin daha fazla fizyolojik nem tutmasn salar.
Sodyum PCA Nedir?
Jun 08, 2019
Derideki Sodyum PCA seviyeleri ocukluk dneminde en yksek seviyededir. Zaman ilerledike, bu seviyeler nemli lde debilir. Sodyum PCA ieren cilt bakm rnlerini kullanmak, yalandka bu seviyelerin artmasna yardmc olabilir. Sodyum PCA ayrca cildi yalandrabilecek serbest radikallerle savaan antioksidanlar ierir. Ayrca cildin genlemesinde yardmc olabilecek D ve E vitaminlerini ierir.
Bu gl nemlendirici birok bitkiden elde edilir, ancak her bitkiden elde edilen sodyum PCA farkl eyler yapmak iin kullanlr. rnein, otlardan ve sebzelerden gelen Sodyum PCA bir yumuatc olarak kullanlabilir. Sodyum PCA hindistancevizi yandan elde edildiinde, bir emlgatr olarak kullanlr. Kiraz veya deniz yosunlarnda bulunan Sodyum PCA, cildin iindeki nemi yenileyebilir. Sodyum PCA ayrca cildi ar gne ndan koruyan belirli tiplerde losyonlarda da kullanlabilir.
Bu madde sadece cilde nem ekmekle kalmaz, ayn zamanda ieride tutulmasna da yardmc olabilir. Bu, tm cilt bakm rnleri iin en uygun hale getirir. Sodyum PCA sabunlarda kullanldnda cilde birok ynden yardmc olabilir. Daha salkl ve yenilenmi bir cilt oluturmak iin ciltte bulunan doal Sodyum PCA ile birlikte alr.
ampuanlarda ve sa kremlerinde kullanlan sodyum PCA sa gvdesinde su tutmaya yarar. Ayn zamanda saa parlaklk ve srama yapabilir. Salar ok kuru olduunda, ynetimi zor, uabilen salara neden olan statik oluabilir. Sodyum PCA, kvrck ve kuru sa ortadan kaldrmak iin sata yeterli nem tutar.
Kk miktarlarda, sodyum PCA`nn kullanmnn zararl olmad dnlmektedir. Hafif toksik olarak kabul edilir, ancak bazen bir toksin olduu dnlen nitrozamin ile birlikte kullanlr. Sodyum PCA kullanmyla ilikili bilinen cilt veya gz tahrii olmamtr.
En efektif nem tutuculardan biri olan hyalronik asit kendi arlnn 1000 kat kadar su tutma kapasitesine sahiptir. Sklatrc etkisi vardr. Cildin esnekliini arttrr. Ciltteki tm hcrelere, nemin iletilmesini salar. Ciltte uzun sre nemlilik salar. Cildi dolgunlatran, uzun sre nemlilik salayan bu rnler gece ve gndz kullanmna uygundur. Ayn zamanda cildin przsz ve eit tonda olmasn salar.
Aktif erikler / Active Ingredients
Sodyum PCA, Sodium PCA hyaluronate, Panthenol
10 x 2 ml
erik:
Amino asit kokteyli: eriinde Sodyum PCA ve cildin kendi yapsnda bulunan 8 eit amino asit ierir.Olgun ciltlerin bakmnda olduka etkilidir. Cildin beslenmesini salarken yeniden yaplanmasna yardmc olur. Glycine Soybean Seed Extract: Soyadan elde edilen protein, glikoprotein, polisakkaritler ile cildin dayanklln artrr, cildi yeniler, cilt hcrelerini canlandrr. UV nlarnn etkisiyle oluan erken yalanma etkilerini ve ciltteki DNA hasarlarn nlemeye yardmc olur. UVA/UVB Koruma Faktr: 15 SPF zelliinde koruma faktr ierir. 50ml
erik: Sodyum PCA: Cildin daha fazla nem tutmasn salayarak kurulua kar korur. Cilt yapsnda da bulunan doal ve nemli bir nemlendirme ajandr.
Amino asit kokteyli: eriinde Sodyum PCA ve cildin kendi yapsnda bulunan 8 eit amino asit ierir.Olgun ciltlerin bakmnda olduka etkilidir. Cildin beslenmesini salarken yeniden yaplanmasna yardmc olur. Bifida Ferment Lysate: Etkinlii kantlanm bir antiaging aktiftir. UV n DNA zerindeki tahribatn engeller. DNA`nn onarlmasna yardmc olarak krklklarn dzenlenmesini salar. 50ml
Limnanthes Alba (Meadowfoam) Seed Oil, Rosa Damascena Flower Water, Beeswax (Cera Alba), Pentylene Glycol, Corylus Avellana (Hazel) Seed Oil, Ormenis Multicaulis Flower Wax, Sodyum PCA Carbonate Decahydrate, Limonene, Citrus Medica Limonum (Lemon) Peel Oil, Osmanthus Fragrans Flower Extract, Anthemis Nobilis Flower Oil, Tocopherol, Citronellol, Geraniol, Citral.
Yal cildiniz varsa rnlerinde ilk sradaki maddelerin ya olmasndan kann. Bu durumda daha ok nemlendirici ajanlardan gliserin, sodyum PCA, hyaluronic asit veya sodyum PCA hyaluronate olmasna dikkat edin.
Sodyum Pca / Cyclopentasiloxane
tp Sodyum Pca / Cyclopentasiloxane
Genel Bak kullanmlar Yan etkiler nlemler Etkileimler Kontrendikasyonlar
Genel Bak
Sodyum Pca / Cyclopentasiloxane kombinasyonu, Cilt artlandrma, Sa yumuatan gibi hastalklarn tedavisinde ve dier durumlarda endikedir.
Sodyum Pca / Cyclopentasiloxane rnnn kullanmna, yan etkilerine, rnle ilgili yorumlara, sorulara, etkileimlere ve nlemlere ilikin detayl bilgiler aadaki gibidir:
kullanmlar
Sodyum Pca / Cyclopentasiloxane, aadaki hastalklarn, durumlarn ve semptomlarn tedavisinde, kontrol altna alnmasnda, nlenmesinde & iyiletirilmesinde kullanlr:
Cilt artlandrma
Sa yumuatan
Daha fazla bilgi: Kullanmlar
Yan etkiler
Aadakiler, Sodyum Pca / Cyclopentasiloxane ihtiva eden ilalardan meydana gelebilecek olas yan etkileri bir listesidir. Bu, geni kapsaml bir liste deildir. Bu yan etkilerin grlmesi muhtemeldir, ancak her zaman ortaya kmaz. Yan etkilerin bazlar nadiren grlse de ok ciddi olabilir. Aadaki yan etkilerden, zellikle de beklemenize ramen gemeyen herhangi birini gzlemlerseniz mutlaka doktorunuza dann.
Cilt tahrii
Kurdeen
Eer, aada listelenenlerin dnda bir yan etki fark ederseniz, tbbi yardm iin doktorunuza dann. Ayrca yan etkileri, yaknnzdaki salk bakanl yetkilisine bildirebilirsiniz.
nlemler
Bu ilac kullanmadan nce, doktorunuzu, gncel olarak kullandnz ilalar, reetesiz kullandnz ilalar (rnein, vitaminler, bitkisel takviyeler, vs.), alerjiler, gemite var olan hastalklarnz ve gncel salk durumunuz (rnein, hamilelik, yaklaan bir ameliyat, vs.) hakknda bilgilendiriniz. Baz salk koullar sizi, ilacn yan etkilerine kar daha duyarl hale getirebilir. Doktorunuz tarafndan ynlendirildiiniz admlar atn ya da rnn zerinde yazlanlar dikkate aln. Dozaj, sizin durumunuza baldr. Durumunuz devam ederse ya da ktleirse, doktorunuza haber verin. Danlacak nemli konular aada listelenmitir.
Hamile, planlama almak iin hamile veya emzirme
Bu bilgi iin ltfen doktorunuza ya da eczacnza dann veya prospektse bakn.
Sodyum Pca / Cyclopentasiloxane ilacna kar ar duyarllk bir kontrendikasyondur. Buna ek olarak, eer aadaki durumlardan birine sahipseniz Sodyum Pca / Cyclopentasiloxane kullanmayn:
Ar duyarllk
Ska Sorulan Sorular
Bu rn kullanrken ar makineleri srmek veya kullanmak gvenli midir?
Eer, Sodyum Pca / Cyclopentasiloxane kullanrken uyuukluk, ba dnmesi, hipotansiyon (tansiyon dkl) ya da ba ars gibi yan etkiler yayorsanz, araba srmeniz ve/veya i makinesi kullanmanz gvenli olmayabilir. Eer kullanlan ila sizde uyuukluk, ba dnmesi meydana getiriyor ya da kan basncnz dryorsa, ara kullanmamalsnz. Ayrca, alkol uyuukluk gibi yan etkileri younlatrd iin, eczaclar hastalara ilala birlikte alkol almamalarn tavsiye ederler. Ltfen Sodyum Pca / Cyclopentasiloxane kullanrken bu etkileri vcudunuzda gzlemleyiniz. Vcudunuza ve salk durumunuza zel tavsiyeler iin daima doktorunuza dann.
Bu ila ya da rnn, bamllk yapc ya da alkanlk oluturucu zellii var mdr?
Birok ila, bamllk yapc ya da ktye kullanma ak bir ekilde piyasaya srlmemektedir. Genellikle bakanlklar, ilalar, denetime tabi bamllk yapc olanlar ve olmayanlar eklinde kategorize eder. rnein, Hindistan`da bu snflandrma H ve X, ABD`de ise II ve V eklindedir. Ltfen, ilacn bu tr zel bir snflandrmaya ait olup olmadndan emin olmak iin kutusunu kontrol edin. Son olarak, bir doktor tavsiyesi olmadan, kendi kendinize tedavi olmaya almayn ve vcudunuzun bamlln arttrmayn.
Bu rn hemen kullanmay brakabilir miyim yoksa yava yava kullanmdan kurtulmu muyum?
Baz ilalar azaltlarak braklmaldr ya da yoksunluk etkisi yaanmamas iin kullanm birden kesilmemelidir. Vcudunuza, salk durumunuza zel tavsiyeler ve kullanabileceiniz dier ilalar iin doktorunuza dann.
Sodyum Pca / Cyclopentasiloxane hakkndaki dier nemli bilgiler
Doz almay unutmak
Eer bir doz ila almay unuttuysanz, fark eder etmez kullann. Eer sonraki doz zamannza ok yaknsa, almay unuttuunuz dozu brakn ve doz takviminize bal kaln. Unuttuunuz dozu tedavi etmek iin ekstra doz almayn. Eer dozlarnz dzenli olarak unutuyorsanz, bir alarm kurun ya da bir aile bireyinizden size hatrlatmasn isteyin. Ltfen, doz takviminizde deiiklik yapmak ya da yakn zaman da ok sayda doz unuttuysanz, almay unuttuunuz dozlar telafi iin doktorunuza dann.
Sodyum Pca / Cyclopentasiloxane doz am
Reetedeki dozdan fazla kullanmayn. lac daha fazla tketmek semptomlarn iyiletirmez; aksine, zehirlenmeye ya da ciddi yan etkilere neden olabilir. Sizin ya da bir yaknnzn ar dozda Sodyum Pca / Cyclopentasiloxane kullandndan pheleniyorsanz, ltfen en yakn hastanenin acil servisinizi ziyaret edin. Doktorlara yardm etmek iin, ila kutusu, iesi ya da etiketi gibi gerekli bilgileri beraberinizde gtrn.
Ayn duruma sahip olduklarn bilseniz ya da benzer durumlar varm gibi grnse bile, ilalarnz bir bakasna vermeyin. Bu durum ar doza sebep olabilir.
Daha fazla bilgi iin, eczacnza dann ya da prospekts kontrol edin.
Sodyum Pca / Cyclopentasiloxane saklanmas
lalar oda scaklnda saklayn, scaktan ve ktan uzak tutun. Prospektste yazmadka ilalar dondurmayn. lalar ocuklarn ve evcil hayvanlarn eriemeyecei bir yerde saklayn.
Prospektste byle yapmanz sylenmedike ilalar tuvalete ya da lavaboya dkmeyin. Bu ekilde atlan ilalar doay kirletebilir. Sodyum Pca / Cyclopentasiloxane ilacn nasl gvenle yok edeceiniz konusunda ltfen doktorunuza ya da eczacnza dann.
Sresi dolmu Sodyum Pca / Cyclopentasiloxane
Tek bir doz son kullanma tarihi gemi Sodyum Pca / Cyclopentasiloxane kullanmak, muhtemelen istenmeyen bir duruma neden olacaktr. Uygun bir tavsiye iin ya da kendinizi iyi hissetmiyorsanz, aile hekiminize ya da eczacnza dann. Son kullanma tarihi gemi ilalar, reetenizdeki durumlarn tedavisinde verimli olmaz. Gvende kalabilmek iin, son kullanma tarihi gemi ilalar kullanmamak ok nemlidir. Eer, kalp rahatszl, nbetler ve yaam tehdit eden alerjiler gibi srekli ila kullanmanz gerektiren kronik bir hastalnz varsa, sresi dolmu ilalarn yerine hemen yenisini alabilmeniz iin aile hekiminizle temasta kalmak ok daha nemlidir.
Dozaj Bilgisi
Ltfen doktorunuza ya da eczacnz dann ya da prospekts okuyun.
Bu sayfay Cite
APA Style Citation
Sodyum Pca / Cyclopentasiloxane –
MLA Style Citation
” Sodyum Pca / Cyclopentasiloxane –
Chicago Style Citation
” Sodyum Pca / Cyclopentasiloxane –
lgili Linkler
cilt artlandrma tedavisinde Sodyum Pca / Cyclopentasiloxane
sa yumuatan tedavisinde Sodyum Pca / Cyclopentasiloxane
Sodyum Pca / Cyclopentasiloxane hakknda daha fazla
Kullanmlar
Yorumlar
Tketici Anketi – Sodyum Pca / Cyclopentasiloxane
Aadakiler, Sodyum Pca / Cyclopentasiloxane iin TabletWise.com`da devam etmekte olan anketin sonulardr. Bu sonular, sadece bu internet sitesinin kullanclarn alglarn gstermektedir. Ltfen tbbi kararlarnz, bir doktorun ya da bir uzmann tavsiyeleri zerinden veriniz.
Kullanmlar, Verimlilik ve Yan Etkiler
Aadakiler, site ziyaretileri tarafndan Sodyum Pca / Cyclopentasiloxane iin sunulan kullanm, alglanan verimlilik ve yan etki grlme skl hakkndaki bilgilerdir:
Bu ne?
Kozmetik ve kiisel bakm rnlerinde Sodyum PCA (pirolidonekarboksilik asit) en ok sa kremleri ve nemlendiricilerin formlasyonunda kullanlr. Sodyum PCA`nn sodyum PCA tuzu, Sodyum PCA, bu rnlerin yan sra ampuanlar, sa spreyleri, kalc dalgalar, cilt tazeleyiciler ve dier sa ve cilt bakm rnlerinde bulunabilir.
Neden kozmetik ve kiisel bakm rnlerinde kullanlr?
Sodyum PCA ve Sodyum PCA, evredeki havadan nem ekerek cildin st katmanlarndaki su ieriini arttrr. Ayrca, sa gvdesini, esnekliini veya parlakln artrarak veya fiziksel olarak veya kimyasal ilemle hasar grm sa dokusunu iyiletirerek san grnmn ve hissini gelitirirler.
z Sodyum PCA pirolidon karboksilik asit, 2 pirolidon 5 karboksilatn sodyum PCA tuzlardr, nsan cildinde bulunan balca Doal Nemlendirme faktrlerinden (NMF) biridir. Sodyum PCA pirolidon karboksilik asitin (Na-Sodyum PCA) su ztleyici cilt bileeni olmas nedeniyle sa bakm ve cilt bakm rnlerinde byk bir etkinlikle kullanld belgelenmitir. Na-Sodyum PCA Doal Nemlendirici Ajan olduu iin esneklik, nemlendirme ve nemlendirme zellii verir. Suda znr olduundan, suda bir ya (O / W) krem baz gelitirmeye karar verdi. Laboratuvarda% 2,5 ve% 5 Na-Sodyum PCA ve% 7,5 gliserin ieren forml gelitirilmitir. Hazrlanan krem, scaklk etkisine referansla stabilitesi asndan daha fazla incelenmitir. yani Oda Scakl -24-28 c, 50 c frnda ve 90 c buzdolabnda, renk, koku, pH, krecik boyutunda ve viskozitesinde deiiklik. Ayrca performans deerlendirmesinin incelenmesine karar verildi. Detaylar Sodyum PCA, Pirolidon Karboksilik Asit anlamna gelir ve kulaa yle gelmese de, cildimizde doal olarak bulunabilen bir eydir. Sodyum PCA`nn sodyum PCA tuzu formu, cilde zde nemli bir bileen ve cildin suya tutunmasna ve gzelce nemli kalmasna yardmc olan harika bir doal nemlendiricidir. Tanm: Sodyum PCA, birok proteinde doal olarak bulunan nadir bir amino asit olan piroglutamik asidin sodyum PCA tuzudur. Konsantrasyon:% 50 (suda znm). GDO iermez, gltensiz. Renksiz ila soluk sar berrak sv, suda znr, pH 6.8-7.4.
CAS: 28874-51-3
INCI Ad: Sodyum PCA (sodyum L-piroglutamat)
Faydalar:
nsan cildinde doal olarak oluur ve nemin hcrelere balanmasndan sorumludur.
Arln birka kez suda tutan son derece su emicidir, bu da onu mkemmel bir nemlendirici yapar
Cilt penetrasyon artrc olarak bilinir
Gliserin veya propilen glikol gibi geleneksel bileiklerden daha gl nemlendirici ajan
Statik elektrii azaltt iin sa bakm iin iyidir.
Kullanm: Formllerin su fazna olduu gibi ekleyin, tipik kullanm seviyesi emlsiyonlarda% 1-10. Yalnzca harici kullanm iindir.
Uygulamalar: Kremler, jeller, losyonlar, sa bakm rnleri, renkli kozmetikler gibi her trl cilt bakm rn.
Mene lkesi: ABD
Hammadde kayna: Orijinal amino asit prolin esas olarak meyvelerden ve hindistancevizi yandan elde edilir.
retim: Prolinden Sodyum PCA oluturmak iin eker ve niastalarn bir fermantasyon ilemi kullanlr.
Hayvan Testi: Hayvanlar zerinde test edilmemitir
GDO: GDO iermez ancak sertifikal deildir
Vegan: Hayvansal kaynakl bileen iermez
SODYUM PCA
SODYUM PCA u ekilde snflandrlr:
Antistatik
Sa bakm
Nemlendirici
Cilt bakm
CAS Numaras 28874-51-3
EINECS / ELINCS No: 249-277-1
COSING REF No: 79910
Chem / IUPAC Ad: Sodyum PCA 5-okso-2-pirrolidinkarboksilat
Sodyum PCA, piroglutamik asidin (Sodyum PCA olarak da bilinir) sodyum PCA tuzudur. Sodyum PCA, insan cildinin doal olarak oluan bir bileenidir ve salkl bir epidermisi koruyan “doal nemlendirme faktrlerinin” (NMF) bir parasdr. Sodyum PCA ok higroskopiktir ve havadan nem eker. Sa ve cilde nem hissi verir. Cilde uygulanan sodyum PCA snrl oranda emilir. Komedojenik deildir, gz ve cildi tahri etmez -% 50`ye varan konsantrasyonlarda bile ve fototoksisite veya duyarlla katkda bulunmaz. Biyolojik olarak hzla paralanabilir. Su ve etanolde znen ve yalarda znmeyen, gl nemlendirici zelliklerinden dolay jel, krem, losyon, ampuan, sa kremi, ruj ve fondtenler dahil birok cilt ve sa bakm rnnde kullanlmaktadr.
Bu Sodyum PCA tamamen doal, sebze bazl bileenlerden elde edilir; hibir trden hayvansal ierik iermez.
INCI: Sodyum PCA
INCI: Sodyum PCA% 50
pH deeri% 6,8-7,4
Dozaj:% 0,5 – 10
Sodyum PCA, bir tr doal nemlendirme faktrdr (NMF). Son yllarda cilt bakm ve sa bakm kozmetiklerinde nemli bir katk maddesi haline gelmektedir. Gliserin, sorbitol ve propandiolden daha gl nemlendirme gcne sahiptir.
Sodyum PCA nedir?
08 Haziran 2019
Ciltteki sodyum PCA seviyeleri ocukluk dneminde en yksektir. Zaman ilerledike, bu seviyeler nemli lde debilir. Sodyum PCA ieren cilt bakm rnlerini kullanmak, yalandka bu seviyelerin artmasna yardmc olabilir. Sodyum PCA ayrca cildi yalandrabilen serbest radikallerle savaan antioksidanlar ierir. Ayn zamanda cildin genlemesine yardmc olabilecek D ve E vitaminlerini ierir.
Bu gl nemlendirici birok bitkiden yaplr, ancak her bitkiden elde edilen sodyum PCA farkl eyler yapmak iin kullanlr. rnein, ifal bitkilerden ve sebzelerden elde edilen Sodyum PCA yumuatc olarak kullanlabilir. Sodyum PCA, hindistancevizi yandan elde edildiinde emlgatr olarak kullanlr. Kiraz veya deniz yosununda bulunan sodyum PCA, cildin iindeki nemi yenileyebilir. Sodyum PCA, cildi ar gne ndan koruyan belirli losyon trlerinde de kullanlabilir.
Bu bileen yalnzca cilde nem ekmekle kalmaz, ayn zamanda cildin iinde kalmasna da yardmc olur. Bu, tm cilt bakm rnleri iin en uygun olmasn salar. Sabunlarda sodyum PCA kullanldnda, cilde birok ynden yardmc olabilir. Daha salkl ve yenilenmi bir cilt oluturmak iin ciltte bulunan doal Sodyum PCA ile alr.
ampuanlarda ve sa kremlerinde kullanlan sodyum PCA, sa aftnda su tutmaya yardmc olur. Ayrca saa parlaklk ve srama katabilir. Sa ok kuruduunda, statik elektrik birikerek ynetimi zor, uuan salara neden olabilir. Sodyum PCA, kvrck ve kuru salar ortadan kaldrmak iin sata yeterli nemi tutar. Kk miktarlarda, sodyum PCA kullanm zararl kabul edilmez. Hafif toksik olduu dnlr, ancak bazen bir toksin olduu dnlen nitrozamin ile birlikte kullanlr. Sodyum PCA kullanmyla ilikili bilinen herhangi bir cilt veya gz tahrii yoktu. Laktik asit ve sodyum PCA pirolidon karboksilik asidin normal kiilerde ve atopik dermatit hastalarnda sodyum PCA lauril slfat yama testi ile indklenen tahri olmu cilt reaksiyonu zerindeki etkileri
Arka plan: Sodyum PCA pirolidon karboksilik asit ve laktik asit gibi doal nemlendirme faktrleri, izole edilmi stratum korneumun nem tutulumunu arttrmada ve in vivo kuru ve pul pul cilt oluumunu azaltmada nemli bir rol oynayabilir. Srfaktan tahriinin kesin mekanizmas tam olarak anlalmamsa da, stratum corneum`un srfaktanlar tarafndan bariyer disfonksiyonunun, lekleme, eritem ve hatta atlama gibi cilt deiikliklerine neden olduu ne srlmtr. Ama: Normal kiilerde ve atopik dermatit hastalarnda sodyum PCA lauril slfatn (SLS) neden olduu tahri olmu cilt reaksiyonunda sodyum PCA pirolidon karboksilik asit (Na Sodyum PCA) ve laktik asidin (LA) etkisini eitli noninvazif lm yntemleriyle deerlendirdik. Yntemler: Sa n kolun be volar blgesinde% 1 SLS yama testi ile 24 saat cilt tahriinden sonra hibir ey (A),% 3 LA +% 3 Na Sodyum PCA (B),% 3 LA (C) uygulamadk, Srasyla gnde iki kez% 3 Na Sodyum PCA (D) ve ara (E). Yamann karlmasndan 30 dakika, 24 saat, 48 saat ve 72 saat sonra grsel skor, transepidermal su kayb (TEWL), su tutma kapasitesi (WHC) ve eritem indeksi lld. Bulgular: 1. 72 saat sonra, B ve C`nin grsel skorlar atopik dermatit hastalarnda A`dan (kontrol) nemli lde daha dkt ve normal kiilerde C`ninki A, D ve E`den nemli lde daha dkt.2 Hem normal (72 saat sonra) hem de atopik dermatit grubunda (48 saat ve 72 saat sonra) B ve C`nin TEWL deerleri, A`nnkinden anlaml derecede dkt. 3. Normal ve atopik dermatitte B, C, D WHC deerleri grup, 48 saat ve 72 saat sonra A grubundan anlaml derecede yksekti. 4. 72 saat sonra, Mexameter`in normal ve atopik dermatit grubundaki B, C ve D eritem indeksleri A`nnkinden anlaml derecede dkt ve C deerleri E`ninkinden anlaml derecede dkt Atopik dermatit grubunda, D deerleri de E`den nemli lde dkt.5 Ortalama grsel skor, Mexameter`in TEWL deeri ve eritem indeksi (r = 0.58, r = 0.64) ile anlaml ekilde korelasyon gsterdi ve TEWL deeri, Mexameter`in eritem indeksi ile anlaml korelasyon gsterdi. (r = 0.64). Sonu: Bu sonular, bir nemlendirme faktrnn topikal olarak uygulanmasnn, stratum korneumun su tutma kapasitesinin iyiletirilmesiyle, geirgenlik bariyerinin srfaktan kaynakl bozulmasn iyiletirebileceini gstermektedir.
Nemlendirici Ajan Olarak Sodyum PCA Pirolidon Karboksilik Asit
zet: Sodyum PCA pirolidon karboksilik asit, 2 pirolidon 5 karboksilatn sodyum PCA tuzlardr,
insan cildinde bulunan balca Doal Nemlendirme faktr (NMF). Sodyum PCA pirolidonun
Karboksilik asit (Na-Sodyum PCA) su ekstraksiyonu olduu iin sa bakm ve cilt bakm rnlerinde byk etkinlik ile kullanlr.
cilt bileeni.
Na-Sodyum PCA Doal Nemlendirici Ajan olduu iin esneklik, nemlendirme ve nemlendirme zellii verir.
suda znr olduundan, su iinde bir ya (O / W) krem baz gelitirmeye karar verdi.
Laboratuvarda% 2,5 ve% 5 Na-Sodyum PCA ve% 7,5 gliserin ieren forml gelitirilmitir.
Hazrlanan krem, temp.i.e.`nin etkisine referansla stabilitesi asndan daha fazla incelenmitir. Oda Scaklnda – 24-280c, 500c frnda ve 900c buzdolabnda, renk, koku, pH, krecik boyutu ve viskozitesinde deiiklik.
ayrca performans deerlendirmesini incelemeye karar verdi.
Anahtar Kelimeler: Na-Sodyum PCA, NMF, Nemlendirici Ajan.
1. Giri:
Kligman tarafndan, “Nemlendirici, topikal olarak uygulanan bir madde veya iaretlerin stesinden gelen bir rn veya
kuru cilt belirtileri . Idson, “Nemlendirici, kuru cilt hissini olumlu ynde etkileyebilen bir madde,
stratum corneum`un su ierii
1
. Kuru cilde suyu geri kazandrmaya ynelik yaklam farkl yol izledi. 1. okklsiyon
2. Nemlilik
3. Birletirilebilecek eksik malzemelerin restorasyonu.
lk yaklam, tkanma, eski veya hasar grm transepidermal su kayb orann azaltmay ierir.
cildi veya baka trl salkl cildi ciddi derecede kuruyan bir ortamn etkisinden korumak iin.
Nemlendirme sorununa ikinci yaklam, nemlendiricilerin atmosferden su ekmek iin kullanlmasdr.
bylece cildin su ieriini tamamlar.
Cildin nemlendirilmesinde nc ve belki de en deerli yaklam, kesin mekanizmay belirlemektir.
kuru cilt durumunda neyin yanl gittiini deerlendirmek ve deitirmek iin doal nemlendirme ileminin
Bu tr aratrmalarn hasarl cildin eksik olduunu gsterdii herhangi bir malzeme2
. Nemlendiriciler genellikle dk molekler arlkl lipitler ve nemlendiriciler, re, gliserin gibi nemlendiriciler ierir.
laktik asit, pirolidon karboksilik asit (Sodyum PCA) ve tuzlar stratum korniuma emilir ve
su ekmek, hidrasyonu artrmak3
1.1 Doal Nemlendirme Faktr (NMF) Doal nemlendirme faktr (NMF) olarak bilinen suda znr hidrofilik maddeler grubu 4
. Stratum cornium`un suda znr bileeninin analizi, amino asit laktik asidin varln gstermitir.
, eker ve pirolidon karboksilik asit. Son malzeme kornifiye edilmilerde nispeten byk konsantrasyonda bulunur.
Son zamanlarda, bu malzemenin tuzlarnn son derece, higroskopik, kendi balarna zld gsterilmitir.
hidrasyon suyu.
Stratum corneum`un (pH5) pH`nda, pirolidon karboksilik asit hemen hemen sadece tuz formunda bulunur. Orada
Sonu, bu malzemenin cilt iin nemli doal Nemlendirici ajanlardan birini temsil edebileceini gstermektedir5
. Laden ve spitzer, tabakada nemli miktarlarda Na-2-pirolidon -5 karboksilat bulunduunu kantlad.
bileik artk kozmetikte kullanm iin ticari olarak mevcuttur6
. 1.2 NMF Bileimi
Amino asitler% 40
Sodyum PCA (Pirolidon karboksilik asit)% 12
Laktatlar% 12
re% 7
NH3, rik asit, glukozamin, kreatinin% 1.5
Sitrat% 0,5
Na% 5, k% 4, Ca% 1.5, Mg% 1.5, Po4% 0.5% 18.5
Sucrore, Organik asit, Peptitler, Dier malzemeler% 8.5
1.3 Pirolidon Karboksilik Asit (Sodyum PCA); (C5H7N03)
Molekler arlk 129.11 7
1.4 Sodyum PCA pirrolidon karboksilik asit (NA-Sodyum PCA); (C5H6NNa03)
Molekler arlk 151.1 8
Na-Sodyum PCA, insan cildinde bulunan en nemli doal nemlendirme faktrlerinden (NME) biridir.
2 Pirolidon-5-Karboksilatn (Na-Sodyum PCA) sodyum PCA tuzlardr ve glutanik asitin dehidrasyonu ile retilir.
ve kokusuz kat formdadr.
Sodyum PCA -2 Pirolidon-5-Karboksilat,% 2 veya daha yksek konsantrasyonda bir nem aktif madde olarak Patentlenmitir.
Sodyum PCA Pirolidon Karboksilatn su emme yetenei9
Bileik% Nem
alm (% 31 bal nem)
%Nem
alm (% 58 bal nem)
Pirolidon Karboksilik Asit
Sodyum PCA Pirolidon Karboksilik Asit 20 61
Gliserin 13 35
1.5 Kozmetiklerde Sodyum PCA Pirolidon Karboksilatn Kullanm 10
1) Sodyum PCA -2-pirolidon-5-karboksilat, NMF`nin nemli bir nemlendirici bileenidir.
2) Kuru cildi nemlendirmede kullanlr.
3) Mkemmel higroskopik ve nemlendirici etkisi gsterir ve bu zellikler bir tuzla elde edilmitir.
form.
4) Cilt ve sa bakm rnleri, gne kremi, makyaj rnleri, Na-Sodyum PCA iin balca uygulamalar arasndadr.
5) Cildi nemlendirir ve rzgardan, souktan korur.
S.Bhise / Int.J.ChemTech Res. 2013,5 (4) 1450
2. Malzemeler ve Yntemler
Laboratuvarda gliserin ve sodyum PCA pirolidon karboksilik ieren O / W formlasyonu gelitirildi
asit (Na-Sodyum PCA). 2.1 Formlasyon Notasyonu
A-% 7,5 gliserinli baz formlasyonu.
B-% 2,5 Na-Sodyum PCA ieren formlasyon.
C-% 5.0 Na-Sodyum PCA ile Formlasyon.
2.2 Bitmi rn iin stabilite almas.
Hazrlanan numunenin tm hzlandrlm test koullarna tabi tutuldu ve 24-28 oda scaklnda tutuldu.
0c, 50 0c frnda ve 5-8 0c buzdolabnda.
40 gnlk hzlandrlm stabilite testi ile stabilite almalar yaplmtr.
2.3 Performans Deerlendirmesi
On gnll ikna edildi ve ardndan seildi. Her gnllye iki krem numunesi verildi.
kontrol yani rnek-A (% 7.5 gliserin) ve dieri rnek-C`dir (% 5 Na-Sodyum PCA). Krem gnde iki kez 3
cm. forehand alan, sa forehand A rnei ve sol forehand C rnei.
iki saatten 30 gne kadar rnek A & C`nin etkisini grmek ve karlatrmak iin kayn.
3. Sonular ve Tartma
1) Renk deiiminin sonucu, oda scaklnda ve 50 0c`de renk deiiminin derecesinin ters olduunu gsterir.
sodyum PCA konsantrasyonu ile orantl, soutmada renkte deiiklik olmad
zet Tbbi ve biyolojik literatr, pirolidon karboksilik asit (Sodyum PCA) ve sodyum PCA tuzunun (Na Sodyum PCA) ciltte, metabolizmasndaki ve fonksiyonlarndaki rol zerine yaplan stresle gzden geirildi. Makale ayrca, biyofiziksel (empedans lm, alfa geveme) ve klinik yntemlerle deerlendirilen Sodyum PCA-Na Sodyum PCA ieren kremler ve losyonlar zerinde Laboratuvarmzda yrtlen 8 yllk deerlendirme almalarnn bir zetini iermektedir. Artk, Sodyum PCA`nn bir nemlendirici ajan olduu ve Sodyum PCA-Na Sodyum PCA tuz sisteminin en az% 2`sini ieren tm kozmetik preparatlarn, yeterli bir aracn kullanlmas kouluyla, ksa veya uzun vadede kuru cilt durumunu iyiletirdii kesin olarak kantlanmtr. (rnein sulu zeltiler etkisizdir). Etki mekanizmas, stratum korneumdaki Sodyum PCA`nn metabolizmas ve fizyolojik rolne referansla tartlmtr.
Piroglutamik asit (ayrca temel formu iin Sodyum PCA, 5-oksoprolin, pidolik asit veya piroglutamat olarak da bilinir) iki farkl enantiyomer olarak bulunur: (2R) veya D ve (2S) veya L.L-formu, glutatyondaki bir metabolittir. 5-oksoprolinaz tarafndan glutamata dntrlen dng. L-Piroglutamik asit, ciltte arginin-sitrlin-ornitin-glutamik yolla retilir. Serbest asit higroskopik deildir; ancak bu asidin sodyum PCA tuzlar gliserinden daha higroskopiktir. Bu nedenle, bu asidin formlasyonu, soyulmay ieren cilt koullar iin dehidrasyona kar bir savunma olarak nerilmektedir. Hydromol Krem (sodyum PCA pirolidon karboksilat (L form) ana bileeni) cildi nemlendiren yumuak bir kremdir. Hydromol Krem, doal olarak oluan bir nemlendirici ajann yan sra ciltten nem kaybn nleyen yalar ierir. Bu kanty gidermeye, cildi yalamaya ve yumuatmaya yardmc olur. Hydromol Krem, egzama, iktiyoz (kaltsal kuru cilt) ve senil kant (yallkta ortaya kabilen kant) gibi kuru cildin bir zellik olduu her trl durumu tedavi etmek iin kullanlr. L-Piroglutamik asit, arkebakterilerden insanlara canl hcrelerde bulunduu bildirilmitir ve canl hcrelerde grlmesi yzyl akn sredir bilinmektedir. Neredeyse her yerde bulunmasna ramen, piroglutamik asidin canl hcrelerdeki rol tam olarak anlalamamtr. Piroglutamik asit, Alzheimer hastal ve ailesel demansta biriken peptitleri de ieren birok nronal peptit ve hormonda bir N-terminal modifikasyonu olarak bulunur. Deiiklik, birok antikor, baz enzimler ve yapsal proteinler ieren proteinlerde de gzlenir.
Doal nemlendirme faktrnn (NMF) birincil bileeni olan yrrolidon karboksilik asit (Sodyum PCA), trevleri dahil – basit2 ve yeni3 esterler ve eker kompleksleri4 dahil – nemlendirme kapasitesi ile ilgili byk ilgi ve aratrma konusudur. topikal uygulama yoluyla stratum korneum.
Sodyum PCA`nn sodyum PCA tuzunu ieren kremler ve losyonlarn cildin nemlenmesine ve kuru pul pul cilt durumlarnn iyiletirilmesine yardmc olduu yaygn olarak bildirilmitir.5,6 Ek olarak, L-pirolidon karboksilatn inko tuzu, antimikrobiyal ve bzc maddeler nedeniyle uzun sreli kozmetik bir bileendir. nitelikler. Bu stun ksaca Sodyum PCA`nn cilt salndaki rolne deinmektedir.7
Kuru cilt
Clar ve Fourtanier, 1981 tarihli kapsaml bir literatr taramasnda, Sodyum PCA`nn bir nemlendirici ajan olarak davrandna ve 8 yllk kendi almalarnda test ettikleri minimum% 2 Sodyum PCA ve Sodyum PCA tuzu ieren tm kozmetik formlasyonlarn kesin kantn bildirdi. uygun aralar verildiinde (sulu solsyonlar olmadan) ksa ve uzun vadeli koullarda gelitirilmi kuru cilt.
Normal veya kozmetik kuru cilde sahip 64 salkl beyaz kadnn katld 2014 klinik almasnda Feng ve ark. stratum corneum`un bantla syrlm rneklerinin, serbest amino asitlerin proteine ve Sodyum PCA`nn proteine oranlarnn nemli lde daha dk olduunu gsterdi. Bu, normal cilde kyasla azalm hidrasyon seviyeleri ile ilikilendirildi. Aratrmaclar, stratum corneum`un derinlii boyunca daha dk NMF seviyelerinin ve azalm kohezivitenin kozmetik kuru cildi karakterize ettii ve bu klinik son noktalarn kuru cilt tedavilerinin yararlln deerlendirmede dikkati hak ettii sonucuna varmtr.8
2016 ylnda Wei ve ark. k aylarnda ve ardndan yaz aylarnda 25 kadn hastann alt bacak derisinin bariyer ilevi, hidrasyonu ve kuruluu hakkndaki deerlendirmelerini bildirdi. Keratinler gibi Sodyum PCA seviyelerinin de yaz aylarnda nemli lde daha yksek olduunu buldular. Yaz aylarnda hidrasyon da daha yksekti, transepidermal su kayb ve grsel kuruluk dereceleri nemli lde daha dkt.9
Atopik dermatit
Brandt ve ark. Tarafndan 2014 klinik almas. atopik dermatit (AD) gelitirmeye yatkn cilt hastalarnda, filagrin metabolitleri arginin ve Sodyum PCA`dan oluan vcut ykamasnn iyi tolere edildiini ve kantnn azaldn ortaya kard. Hastalar rn beendiklerini ve yaam kalitelerini artrdklarn belirtmilerdir.10
O yl daha sonra Jung ve ark. Sodyum PCA seviyeleri ve dier faktrlerin AD`nin klinik iddeti ile ilikisini karakterize etmitir. Spesifik olarak, 73 denek zerinde yaplan bir almada (21 hafif AD, 21 orta ila iddetli AD, 13 filaggrin gen mutasyonu iin negatif kontrol olarak X`e bal iktiyoz ve 18 salkl kontrol), aratrmaclar transepidermal su kayb, tabaka korneum hidrasyonu ve cilt yzeyi pH`. AD`li deneklerde iltihapl lezyonlarda Sodyum PCA seviyelerinin ve kaspaz-14`n lezyonsuz deriye kyasla daha dk olduunu bulmulardr. Bu seviyeler ayrca egzama alan ve ciddiyet indeksi skorlarnn yan sra cilt bariyeri ilevi ile llen klinik AD iddeti ile de ilikiliydi.11
Sodyum PCA Pirolidon Karboksilik Asit
CAS No: 28874-51-3
EINECS .: 249-277-1
Nemlendirici ajan
Grnm: Ak sar sv
Sodyum PCA Pirolidon Karboksilik Asit, Sodyum Pca
HIZLI LNKLER
Alkil Poliglukozitler
Amino Asit Yzey Aktif Maddeler
Kozmetik Katk Maddeleri
Glifosat yzey aktif madde
Hzl Ayrntlar
CAS No: 28874-51-3
Dier simler: Sodyum Pca, Sodyum L-piroglutamat
Grn: Soluk sar liyofilize ktle
Aklama
Sodyum PCA, bir tr doal nemlendirme faktrdr. Son yllarda cilt bakm ve sa bakm kozmetiklerinde nemli bir katk maddesi haline gelmektedir.
Daha gl nemlendirme gliserin, sorbitol ve propandiyolden daha gtr ve zehirsiz, tahri edici ve alerjik deildir.
Esas olarak krem kozmetikler, solsyonlar, ampuan vb. Gibi di macunu, merhem ilalar, ttn, deri, slatclar iin kaplamalar ve kimyasal elyaf boyama yardmclar, yumuatclar, antistatik maddeler iin gliserin yerine kullanlr, ayrca biyokimyasal reaktiflerdir.
Kozmetik yaltm maddesi
Sodyum PCA Doal nemlendirme faktr departman nemli bileenlerden biridir, yksek nem emilimi ve toksik olmayan, uyarc olmayan, iyi stabilite, modern cilt bakm ideal doal makyaj salk bakm rnleridir, cilt ve salar slatarak, Yumuaklk, elastikiyet ve parlaklk ve antistatik zellik.
Cilt beyazlatma ajan
Sodyum PCA mkemmel bir cilt beyazlatma maddesidir, tirozin oksidaz aktivitesinin inhibisyonu ciltte biriken “melanoid” oluumunu nleyerek cildin beyaz olmasn salar.
