TRICLOSAN (TRKLOSAN)
TRICLOSAN (TRKLOSAN)
EC Number:222-182-2
CAS Number:3380-34-5
SYNONMYS:
2,4,4′-trichloro-2′-hydroxydiphenyl ether; 2-Hydroxy-2′,4,4′-trichlorodiphenyl Ether; Aquasept; Clearasil Daily Face Wash; Cliniclean; DP300, Irgasan; Irgasan DP 300; Irgasan DP300; Irgasan-DP300; Manusept; Microshield T; Oxy Skin Wash; pHisoHex; Sapoderm; Ster Zac Bath Concentrate; Ster-Zac Bath Concentrate; SterZac Bath Concentrate; Tersaseptic; Triclosan; Trisan; triclosan; 3380-34-5; 5-CHLORO-2-(2,4-DICHLOROPHENOXY)PHENOL; 2,4,4′-Trichloro-2′; hydroxydiphenyl ether; Irgasan; Cloxifenolum; Triclosanum; Irgasan DP300; Stri-Dex Face Wash; Aquasept; Sapoderm; Phenol, 5-chloro-2-(2,4-dichlorophenoxy)- Lexol 300; Stri-Dex Cleansing Bar; 5-Chloro-2-(2,4-dichloro-phenoxy)-phenol; Triclosanum [INN-Latin]; CH 3565; Irgasan DP 300; DP-300; Caswell No. 186A; Cloxifenol; C12H7Cl3O2; Triclosan [USAN:BAN:INN]; UNII-4NM5039Y5X; HSDB 7194; CHEBI:164200; 2-Hydroxy-2′,4,4′-trichlorodiphenyl Ether; Triclosan (USP/INN); Ether, 2′-hydroxy-2,4,4′-trichlorodiphenyl; Phenyl ether, 2′-hydroxy-2,4,4′-trichloro-; EINECS 222-182-2; IN1424; CHEMBL849; EPA Pesticide Chemical Code; 054901; BRN 2057142; Stri-Dex cleansing bar (TN); 2,4,4′-Trichloro-2′-hydroxy diphenyl ether; XEFQLINVKFYRCS-UHFFFAOYSA-N; 4NM5039Y5X; 88032-08-0; CH-3565 TCL; NCGC00159417-02; NCGC00159417-05; NCGC00159417-06; DSSTox_CID_12498; DSSTox_RID_78958; DSSTox_GSID_32498; Q-201866; Cliniclean; Trisan; Microshield TOxy Skin Wash; 2-(2,4-dichlorophenoxy)-5-chlorophenol; SMR000471847; CAS-3380-34-5; SR-01000762974; SterZac Bath Concentrate; Ster Zac Bath Concentrate; Ster-Zac Bath Concentrate; Trichlorosan; Sterzac; CCRIS 9253; Triclosan USP; 1nhg; Triclosan [USAN:USP:INN:BAN]; Triclosan; Irgasan; Irgasan DP 30; TCCP; Neostrata Antibacterial Facial Cleanser; Triclosan Reckitt Bran; 3p9t; 4w9n; SSL Brand of Triclosan; Clearasil DailyFace Wash; AC1L1KMN; Triclosan Pharmachem; Brand; D00CSQ; D09SNH; Dermtek Brand of Triclosan; Epitope ID:119683; Reckitt Brand of Triclosan; SCHEMBL3269; KSC498G0D; MLS001066347; MLS001074876; MLS001335937;; MLS001335938; Pharmachem Brand of Triclosan; BDBM8726; ZINC2216; DTXSID5032498; CTK3J8301; BII1002; MolPort-003-666-702; Trans Canaderm Brand of Triclosan; ZX-AFC000465; GlaxoSmithKline Brand of Triclosan; HMS2093L17; HMS2270M06; HMS3259K19; HMS3715H11; Pharmakon1600-01505465; trichloro-2′-hydroxydiphenyl ether; Irgasan, >=97.0% (HPLC); DNDI1246774; HY-B1119; KS-000009AG; Tox21_111648; Tox21_400079; ANW-42338; DP 300; GA5716; MFCD00800992; NSC759151; Procter & Gamble Brand of Triclosan; s4541; SBB058565; STL451034; 5-chloro-(2,4-dichlorophenoxy)phenor; AKOS015850380; Tox21_111648_1; API0004498; CCG-213459; CH-3635; CS-4718; DB08604; KS-5356; MCULE-2614621397; NC00516; NSC-759151; RTR-014090; TRA0068104; WL-1001; NCGC00159417-03; NCGC00159417-04; NCGC00159417-07; NCGC00159417-08; AC-10667; AJ-08144; AK-73001; BC678270; BR-73001; CJ-00083; CPD000471847; LS-67854; SAM002554907; SC-16588; ZB000507; 5-chloro-2-(2, 4-dichlorophenoxy)phenol; SBI-0206807.P001; AX8020299; KB-197273; Phenol,5-chloro-2-(2,4-dichlorophenoxy)- ST2411924; TL8002539; TR-014090; 5-chloro-2-(2,4-di-chloro-phenoxy)-phenol; FT-0609773; ST50826110; CH-3565, Lexol 300, Irgasan DP 300; C12059; D06226; J10025; M-6446; S00100; 5-Chloro-2-(2,4-dichlorophenoxy)phenol, 97%; AB00698074_08; Triclosan (Irgasan) 10 microg/mL in Cyclohexane; Triclosan, Antibiotic for Culture Media Use Only; 380T345; A821950; C-18186; 2-[2,4-bis(chloranyl)phenoxy]-5-chloranyl-phenol; I01-2897; SR-01000762974-2; SR-01000762974-3; BRD- K41731458-001-04-5; BRD-K41731458-001-09-4; Triclosan, certified reference material, TraceCERT(R); 5-Chloro-2-(2, 4-dichlorophenoxy) phenol, 99% 25g F2173-0825; Triclosan, United States Pharmacopeia (USP) Reference Standard; Triclosan, Pharmaceutical Secondary Standard; Certified Reference Material; 112099-35-1; 1155174-27-8; 164325-69-3; 261921-78-2; tiriklosan; tiriklozan; triklozan; tiriclosan; trclosan; trclozan; tiriclosan;
Triclosan is an antibacterial and antifungal agent. It is a polychloro phenoxy phenol. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes. According to the Food and Drug Administration (FDA) at the present time there is no evidence that triclosan in personal care products provides an extra benefit to health beyond its anti-gingivitis effect in toothpaste. The FDA does not recommend changing consumer use of triclosan containing products one way or the other due to currently insufficient safety evidence. Studies by the Environmental Protection Agency (EPA) found triclosan to be an effective antibacterial. Triclosan safety is currently under review by the FDA and Health Canada. Triclosan is only found in individuals that have used or taken this drug.Triclosan (TCS) is a broad-spectrum antimicrobial agent that has been added to personal care products, including hand soaps and cosmetics, and impregnated in numerous different materials ranging from athletic clothing to food packaging. The constant disposal of TCS into the sewage system is creating a major environmental and public health hazard. Owing to its chemical properties of bioaccumulation and resistance to degradation, TCS is widely detected in various environmental compartments in concentrations ranging from nanograms to micrograms per liter. Epidemiology studies indicate that significant levels of TCS are detected in body fluids in all human age groups. We document here the emerging evidence-from in vitro and in vivo animal studies and environmental toxicology studies-demonstrating that TCS exerts adverse effects on different biological systems through various modes of action. Considering the fact that humans are simultaneously exposed to TCS and many TCS-like chemicals, we speculate that TCS-induced adverse effects may be relevant to human health.
Are There Benefits of Triclosan?
For some consumer products, there is evidence that triclosan provides a benefit. In 1997, FDA reviewed extensive effectiveness data on triclosan in Colgate Total toothpaste. The evidence showed that triclosan in that product was effective in preventing gingivitis.For other products, such as over-the-counter (OTC) consumer antiseptic products, FDA has not received evidence that triclosan provides a benefit to human health. At this time, FDA doesn’t have evidence that triclosan in OTC consumer antibacterial soaps and body washes provides any benefit over washing with regular soap and water.In December 2017, the FDA issued a final rule regarding certain OTC health-care antiseptic products. As a result, companies will not be able to use triclosan or 23 other active ingredients in these products without premarket review due to insufficient data regarding their safety and effectiveness.
Triklosan, antibakteriyel ve antifungal bir maddedir. Bir polikloro fenoksi fenolüdür. Sabun, cilt kremleri, di macunu ve deodorant gibi kiisel bakm ürünlerinde ve plastik dorama tahtalar, spor ekipmanlar ve ayakkablar gibi ev eyalarnda koruyucu ve antimikrobiyal ajan olarak yaygn bir ekilde kullanlmaktadr. Gda ve laç daresi (FDA) ‘ya göre u anda kiisel bakm ürünlerindeki triklosann di macundaki anti-gingivitis etkisinin ötesinde sala ekstra fayda saladna dair bir kant yoktur. FDA, u anda yeterli güvenlik kant bulunmamas nedeniyle triklosan içeren ürünlerin tüketici kullanmn bir ekilde deitirmeyi önermemektedir. Çevre Koruma Ajans (EPA) tarafndan yaplan çalmalar triklosann etkili bir antibakteriyel olduunu bulmutur. Triklosan güvenlii u anda FDA ve Health Canada tarafndan gözden geçirilmektedir. Triklosan sadece bu ilac kullanan veya alan bireylerde bulunur. Triklosan (TCS), el sabunlar ve kozmetikler de dahil olmak üzere kiisel bakm ürünlerine eklenmi ve atletik giysiden gda ambalajna kadar çok çeitli materyallere emprenye edilmi geni spektrumlu bir antimikrobiyal maddedir. TCS’nin kanalizasyon sistemine sürekli olarak atlmas, büyük bir çevresel ve halk sal tehlikesi yaratmaktadr. Biyolojik birikim ve bozunma direncinin kimyasal özellikleri nedeniyle, TCS, nanogramlardan litre bana mikrogramlara kadar deien konsantrasyonlarda çeitli çevresel bölmelerde yaygn olarak tespit edilir. Epidemiyoloji çalmalar, tüm insan ya gruplarnda vücut svlarnda önemli düzeyde TCS bulunduunu göstermektedir. Biz burada ortaya çkan kantlar – in vitro ve in vivo hayvan çalmalarndan ve çevresel toksikoloji çalmalarndan – TCS’nin farkl etki mekanizmalar araclyla farkl biyolojik sistemler üzerinde olumsuz etkiler sergilediini kantlyoruz. nsanlarn ezamanl olarak TCS’ye ve birçok TCS benzeri kimyasallara maruz kaldklar göz önüne alndnda, TCS’nin neden olduu yan etkilerin insan sal ile ilgili olabileceini düünüyoruz.
Triclosan’n Faydalar Var m?
Baz tüketici ürünleri için, triklosann bir fayda saladna dair kantlar vardr. 1997 ylnda FDA, Colgate Total di macununda triklosan üzerinde kapsaml etkililik verilerini gözden geçirdi. Kantlar, bu üründe triklosann dieti iltihabnn önlenmesinde etkili olduunu gösterdi. Reçetesiz (OTC) tüketici antiseptik ürünleri gibi dier ürünler için, FDA triklosann insan salna fayda saladna dair bir kant elde etmemitir. uanda, FDA, OTC tüketici antibakteriyel sabunlarnda ve vücut ykamalarnda triklosann düzenli sabun ve suyla ykamann herhangi bir yarar olduuna dair kantlara sahip deildir. Aralk 2017’de FDA, belirli OTC salk bakm ürünü antiseptik ürünlerine ilikin nihai bir kural yaynlad. Sonuç olarak, irketler bu ürünlerdeki triklosan veya 23 dier aktif bileeni, güvenlik ve etkinliklerine ilikin yetersiz veriler nedeniyle premarket incelemeden kullanamazlar.